CN113164405B - Hydroxypropyl methylcellulose hollow capsule - Google Patents

Hydroxypropyl methylcellulose hollow capsule Download PDF

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Publication number
CN113164405B
CN113164405B CN202080006151.1A CN202080006151A CN113164405B CN 113164405 B CN113164405 B CN 113164405B CN 202080006151 A CN202080006151 A CN 202080006151A CN 113164405 B CN113164405 B CN 113164405B
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CN
China
Prior art keywords
shell
groove
hollow
hole
medicine
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CN202080006151.1A
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Chinese (zh)
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CN113164405A (en
Inventor
俞愈
俞栋
俞三愈
俞学文
王孟军
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Shaoxing Kangke Capsule Co ltd
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Shaoxing Kangke Capsule Co ltd
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Priority to PCT/CN2020/103380 priority Critical patent/WO2022016397A1/en
Publication of CN113164405A publication Critical patent/CN113164405A/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Abstract

A hydroxypropyl methylcellulose hollow capsule comprises a first shell, wherein a second shell is sleeved on the upper side of the first shell, a chamfer angle is arranged on the upper side of the first shell, a fixing ring is arranged on the surface of the first shell, a first clamping groove is formed in the fixing ring, and the lower end of the second shell is clamped with the first clamping groove; the through hole is arranged in the fixing ring, and the second clamping grooves are formed in the upper side and the lower side of the through hole. Through the hollow spacing post that sets up in the inside of through-hole and spacing groove, make hollow spacing post can be fixed first shell and second shell more firmly, reduced the hollow capsule because of the circumstances of medicine effluvium that closed unstability leads to take place, through the chamfer that the department set up of the medicine inlet at first shell, can play certain circumstances that prevents the medicine because of rocking effluvium to the leakproofness of capsule has been improved.

Description

Hydroxypropyl methylcellulose hollow capsule
Technical Field
The invention belongs to the technical field of hollow capsules, and particularly relates to a hydroxypropyl methylcellulose hollow capsule.
Background
The encapsulated medicine is generally a powder or granules which is irritating to the esophagus and gastric mucosa, or a medicine which is bad in taste, easy to volatilize, easy to be decomposed by saliva in the oral cavity, and easy to be inhaled into the trachea. The medicines are filled into capsules, so that the medicine property of the medicines is protected from being damaged, and the digestive organs and the respiratory tract are protected. The hypromellose empty capsule is a capsule, is mainly used in the medicine dispensing of rheumatoid arthritis in the aspect of medicine, and belongs to pharmaceutic adjuvant.
Empty capsule includes two shells and inside medicine, and two shells are most directly through the frictional force card together, and set up like this, and it is easy not hard up to have lived the shell to probably lead to the medicine to spill over, influence the storage time and the drug effect of medicine.
Disclosure of Invention
The invention aims to provide a hydroxypropyl methylcellulose hollow capsule, wherein a first shell and a second shell can be fixed more firmly by a hollow limiting column arranged in a through hole and a limiting groove, the medicine scattering caused by unstable closing of the hollow capsule is reduced, and the medicine scattering can be prevented to a certain extent by a chamfer arranged at a medicine inlet of the first shell, so that the tightness of the capsule is improved, and the existing technical problems are solved.
In order to solve the technical problems, the invention is realized by the following technical scheme:
a hydroxypropyl methylcellulose hollow capsule comprises a first shell, wherein a second shell is sleeved on the upper side of the first shell, a chamfer is arranged on the upper side of the first shell, a fixing ring is arranged on the surface of the first shell, a first clamping groove is formed in the fixing ring, and the lower end of the second shell is clamped with the first clamping groove;
the through hole has been seted up to solid fixed ring's inside, and the second draw-in groove has all been seted up to the upper and lower both sides of through-hole, and the second shell stretches into the surface of first draw-in groove and has seted up the spacing groove, and the inside of spacing groove and through-hole is provided with hollow spacing post, and the triangle fixture block is installed to the both sides of hollow spacing post, triangle fixture block and second draw-in groove joint.
Optionally, an annular tapered block is installed at the bottom of the first card slot, and the annular tapered block is clamped between the first housing and the second housing.
Optionally, a backing plate is mounted at the top of the inner wall of the second shell, and the medicine inlet of the first shell is matched with the backing plate.
Optionally, a plurality of annular inclined plane fixture blocks are mounted on the surface of the first shell, a plurality of annular grooves are formed in the inner wall of the second shell, and the annular inclined plane fixture blocks are clamped in the annular grooves.
Optionally, the corners of the fixing ring are provided with fillets.
Optionally, the plurality of annular grooves are evenly distributed on the inner wall of the second housing.
The embodiment of the invention has the following beneficial effects:
according to the embodiment of the invention, the hollow limiting columns are arranged in the through holes and the limiting grooves, so that the first shell and the second shell can be fixed more firmly by the hollow limiting columns, the medicine scattering condition of the hollow capsule caused by unstable closing is reduced, the medicine scattering condition can be prevented to a certain extent by the chamfer arranged at the medicine inlet of the first shell, and the tightness of the capsule is improved.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Drawings
FIG. 1 is a schematic perspective view of an embodiment of the present invention;
FIG. 2 is a schematic cross-sectional view of an embodiment of the present invention;
FIG. 3 is an enlarged view of a portion of FIG. 2;
fig. 4 is a schematic structural diagram of a portion a in fig. 3.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
To maintain the following description of the embodiments of the present invention clear and concise, a detailed description of known functions and known components of the invention have been omitted.
Referring to fig. 1-4, in the present embodiment, a hypromellose empty capsule is provided, including a first shell 2, a second shell 1 is sleeved on an upper side of the first shell 2, a chamfer 3 is disposed on an upper side of the first shell 2, a fixing ring 4 is mounted on a surface of the first shell 2, a first clamping groove 5 is disposed inside the fixing ring 4, and a lower end of the second shell 1 is clamped with the first clamping groove 5;
through-hole 6 has been seted up to solid fixed ring 4's inside, and second draw-in groove 10 has all been seted up to the upper and lower both sides of through-hole 6, and spacing groove 7 has been seted up to the surface that second shell 1 stretched into first draw-in groove, and the inside of spacing groove 7 and through-hole 6 is provided with hollow spacing post 8, and triangle fixture block 9 is installed to hollow spacing post 8's both sides, and triangle fixture block 9 and second draw-in groove 10 joint.
The application of one aspect of the embodiment is as follows: after 2 first shells are packed into to the medicine, cup joint second shell 1 at 2 upsides of first shell, make the lower extreme joint of second shell 1 in first draw-in groove 5, then insert hollow spacing post 8 in through-hole 6, make the one end joint of hollow spacing post 8 in spacing groove 7 to drive 9 cards of triangle fixture block and go into in second draw-in groove 10, thereby accomplished the installation to first shell 2 and second shell 1.
Through the hollow spacing post 8 that sets up in the inside at through-hole 6 and spacing groove 7, make hollow spacing post 8 can be fixed first shell 2 more firm with second shell 1, reduced the hollow capsule and taken place because of the circumstances that closed unstable medicine that leads to spills out, through chamfer 3 that the department of medicine inlet at first shell 2 set up, can play certain prevention medicine because of rocking the circumstances of spilling out to the leakproofness of capsule has been improved.
In one aspect of the present embodiment, the annular tapered block 11 is installed at the bottom of the first card slot 5, the annular tapered block 11 is clamped between the first housing 2 and the second housing 1, and the annular tapered block 11 is provided to reduce the occurrence of spilling the medicine between the first housing 2 and the second housing 1.
In one aspect of this embodiment, the pad 14 is installed on the top of the inner wall of the second housing 1, the medicine inlet of the first housing 2 is fitted on the pad 14, and the pad 14 is fitted with the chamfer provided on the second housing, so as to increase the tightness of the closure of the first housing 2 and the second housing 1, and make the medicine in the first housing 2 less prone to escape.
In one aspect of the present embodiment, a plurality of annular inclined surface fixture blocks 13 are installed on the surface of the first housing 2, a plurality of annular grooves 12 are opened on the inner wall of the second housing 1, and the annular inclined surface fixture blocks 13 are clamped in the annular grooves 12.
In one aspect of the present embodiment, the corners of the fixing ring 4 are each provided with a rounded corner.
In one aspect of the present embodiment, a plurality of annular grooves 12 are uniformly distributed on the inner wall of the second housing 1.
The structural material used in the device is the same as the material of the capsule.
The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand the invention for and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims (6)

1. A hypromellose empty capsule is characterized by comprising: the device comprises a first shell (2), wherein a second shell (1) is sleeved on the upper side of the first shell (2), a chamfer (3) is arranged on the upper side of the first shell (2), a fixing ring (4) is mounted on the surface of the first shell (2), a first clamping groove (5) is formed in the fixing ring (4), and the lower end of the second shell (1) is clamped with the first clamping groove (5);
through-hole (6) have been seted up to the inside of solid fixed ring (4), second draw-in groove (10) have all been seted up to the upper and lower both sides of through-hole (6), and spacing groove (7) have been seted up to the surface that second shell (1) stretched into first draw-in groove, and the inside of spacing groove (7) and through-hole (6) is provided with hollow spacing post (8), and triangle fixture block (9) are installed to the both sides of hollow spacing post (8), and triangle fixture block (9) and second draw-in groove (10) joint.
2. A hypromellose empty capsule according to claim 1, wherein the bottom of the first slot (5) is provided with a ring-shaped conical block (11), and the ring-shaped conical block (11) is clamped between the first casing (2) and the second casing (1).
3. The hypromellose empty capsule according to claim 1, characterized in that a backing plate (14) is mounted on the top of the inner wall of the second shell (1), and the drug inlet of the first shell (2) is fitted on the backing plate (14).
4. The hypromellose hollow capsule according to claim 1, wherein a plurality of annular inclined plane fixture blocks (13) are installed on the surface of the first shell (2), a plurality of annular grooves (12) are formed on the inner wall of the second shell (1), and the annular inclined plane fixture blocks (13) are clamped in the annular grooves (12).
5. A hypromellose empty capsule according to claim 1, wherein the corners of the fixing ring (4) are provided with rounded corners.
6. A hypromellose macrocapsule as claimed in claim 4, wherein a plurality of annular grooves (12) are evenly distributed on the inner wall of the second shell (1).
CN202080006151.1A 2020-07-22 2020-07-22 Hydroxypropyl methylcellulose hollow capsule Active CN113164405B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2020/103380 WO2022016397A1 (en) 2020-07-22 2020-07-22 Hydroxypropyl methylcellulose hollow capsule

Publications (2)

Publication Number Publication Date
CN113164405A CN113164405A (en) 2021-07-23
CN113164405B true CN113164405B (en) 2022-09-06

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Family Applications (1)

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WO (1) WO2022016397A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792451A (en) * 1986-12-20 1988-12-20 Su-Heung Capsule Co., Ltd. Medicinal capsule
CN208448178U (en) * 2017-10-10 2019-02-01 新昌县凯泰胶丸有限公司 A kind of capsule structure for preventing drug from leaking
CN208785315U (en) * 2018-05-15 2019-04-26 浙江凯润药业股份有限公司 A kind of double-layer hollow capsule
CN211050267U (en) * 2019-08-15 2020-07-21 新昌县联通胶囊有限公司 Plant hollow capsule

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58468B1 (en) * 1984-10-25 1993-09-22 Warner Lambert Co Method for sealing capsules and capsule
KR0124764Y1 (en) * 1995-09-23 1998-09-15 양주환 Medical capsule
ES2234306T3 (en) * 1998-09-28 2005-06-16 Warner-Lambert Company Llc ENTERIC ADMINISTRATION AND VIA COLON USING HPMC CAPSULES.
CN204352220U (en) * 2014-11-25 2015-05-27 浙江宏辉胶丸有限公司 A kind of capsule being provided with reinforcement button
CN206587195U (en) * 2016-11-29 2017-10-27 新昌县渲渲工业产品设计有限公司 A kind of capsule for preventing that medicine from leaking
CN110115685A (en) * 2019-06-19 2019-08-13 江苏力凡胶囊有限公司 A kind of empty hard capsule of the filling liquid with closing component structure
CN211050315U (en) * 2019-08-13 2020-07-21 浙江华光胶囊股份有限公司 Hollow capsule suitable for traditional Chinese medicine capsule preparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792451A (en) * 1986-12-20 1988-12-20 Su-Heung Capsule Co., Ltd. Medicinal capsule
CN208448178U (en) * 2017-10-10 2019-02-01 新昌县凯泰胶丸有限公司 A kind of capsule structure for preventing drug from leaking
CN208785315U (en) * 2018-05-15 2019-04-26 浙江凯润药业股份有限公司 A kind of double-layer hollow capsule
CN211050267U (en) * 2019-08-15 2020-07-21 新昌县联通胶囊有限公司 Plant hollow capsule

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CN113164405A (en) 2021-07-23
WO2022016397A1 (en) 2022-01-27

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