CN113142232A - Seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof - Google Patents
Seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof Download PDFInfo
- Publication number
- CN113142232A CN113142232A CN202110446578.XA CN202110446578A CN113142232A CN 113142232 A CN113142232 A CN 113142232A CN 202110446578 A CN202110446578 A CN 202110446578A CN 113142232 A CN113142232 A CN 113142232A
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- China
- Prior art keywords
- metalaxyl
- clothianidin
- prothioconazole
- seed treatment
- treatment agent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pretreatment Of Seeds And Plants (AREA)
Abstract
The invention provides a seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof, wherein the weight ratio of prothioconazole, metalaxyl-M and clothianidin is 1-5: 1-20; can be used for seed treatment and prevention of crop diseases and insect pests.
Description
Technical Field
The invention belongs to the field of pesticides, and particularly relates to a seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof.
Background
Prothioconazole is a triazolethione bactericide, and belongs to sterol demethylation (ergosterol biosynthesis) inhibitors. Has the characteristics of selectivity, protectiveness, treatment, persistence and the like; can be used for preventing and treating various crop diseases. Metalaxyl-M (International name: Metaloxyl-M) can penetrate the seed coat and can be systemically transported to various parts of the plant as the seed germinates and grows. Can be used for seed treatment to prevent and treat various seed-borne and soil-borne diseases caused by lower fungi. Has better control effect on corn root rot and stem base rot. Clothianidin acts primarily by stimulating nicotinic acetylcholine receptors, affecting the nerve synapses in the insect central nervous system. Has systemic property, and can be absorbed and conducted by root. Is mainly used for controlling sucking insects and chewing insects. Has better control effect on grubs. No report related to the preparation of seed treatment agent by combining prothioconazole, metalaxyl-M and clothianidin exists in the prior art
Disclosure of Invention
The invention provides a seed treatment agent, which contains prothioconazole, metalaxyl-M and clothianidin and can be used for treating crop seeds to effectively prevent and control crop diseases and insect pests.
The invention is realized by the following modes:
a seed treatment agent contains prothioconazole, metalaxyl-M and clothianidin, and the weight ratio of the prothioconazole, the metalaxyl-M and the clothianidin is 1-5: 1-20. Preferably, the weight ratio of the prothioconazole, the metalaxyl-M and the clothianidin is 1-2: 1-10.
The dosage form of the seed treating agent is a suspended seed coating agent, wettable powder and water dispersible granules. The dosage form of the seed treatment agent is preferably suspension seed coating agent.
The percentage content of the active ingredients of the seed treatment agent is 10-65%. Preferably, the percentage content of the active ingredients of the seed treatment agent is 15-50%
The seed treatment agent is used for preventing and treating crop diseases and insect pests. Preferably the crop is maize. The preferred diseases are root rot and grub.
Compared with the prior art, the invention has the following beneficial effects:
1. the prothioconazole and the metalaxyl-M show different combined effects on the corn root rot, and when the mass ratio of the prothioconazole to the metalaxyl-M is 2: 1-1: 1, the composition shows synergistic effect on the corn root rot; the rest of the mixture ratio shows additive effect; 2. clothianidin and thiamethoxam can be used for controlling corn grubs, and the biological activity of the clothianidin is obviously higher than that of the thiamethoxam; 3. compared with thiamethoxam, the combination of clothianidin and a bactericide (prothioconazole and metalaxyl-M) can obviously improve the control effect of the bactericide on corn root rot; 4. the dosage of the suspension seed coating agent prepared by the invention is 400-500ml/100kg of seeds, the corn diseases and insect pests can be effectively controlled, and the control effect is more than 90%. And field observation shows that the fertilizer is safe for corn crops.
Detailed Description
The following detailed description of specific embodiments of the present invention is provided in conjunction with examples, but it should be understood that the scope of the present invention is not limited to the specific embodiments.
Example 1 indoor bacteriostatic test of compound drug on root rot pathogen
Pathogenic bacteria to be tested: collecting root rot bacteria and corn field, separating, purifying, culturing, and storing
The test method comprises the following steps: the growth rate method was used for the test. On the basis of the pilot test, the drug stock solution was diluted with acetone to 5 concentrations in series. Sterilizing PDA culture medium, cooling, adding the prepared medicinal liquid, and shaking to obtain toxic culture medium containing test agents with series concentrations, with the addition of acetone of the same amount as control. Each treatment was set to 4 replicates. And (3) beating a 5mm bacterial cake with a puncher from pathogenic bacteria, inoculating the bacterial cake to PDA containing medicine, culturing at 25 ℃, measuring the diameter of a bacterial colony by a cross method after 96 hours, and calculating the bacteriostasis rate.
The inhibitory rate (%) - ((control colony diameter (mm))/(control colony diameter (mm) — (5 mm)). times.100%)
Regression analysis was performed based on the logarithm of drug concentration (abscissa) and the corresponding probability value of hyphal growth inhibition rate (ordinate), and the virulence regression equation y ═ a + bx was determined, and the drug inhibition concentration was calculated (EC 50). CTC values were used to evaluate the combination effect between agents.
TABLE 1 determination of the synergistic effect of prothioconazole and metalaxyl-M on corn root rot
| Medicament | EC50(mg/L) | Confidence interval | CTC value |
| Propylthio compound | 0.424 | 0.213-0.789 | - |
| Smart nail | 3.081 | 1.538-6.647 | - |
| 8∶1 | 0.532 | 0.335-0.873 | 88.15 |
| 4∶1 | 0.527 | 0.335-0.862 | 97.22 |
| 2∶1 | 0.448 | 0.250-0.802 | 132.82 |
| 1∶1 | 0.615 | 0.388-1.060 | 121.21 |
| 1∶2 | 0.962 | 0.607-2.019 | 103.69 |
| 1∶4 | 1.325 | 0.836-3.097 | 103.19 |
| 1∶8 | 2.170 | 1.069-19.781 | 83.70 |
As can be seen from Table 1, the prothioconazole and the metalaxyl-M show different combined effects on the corn root rot, and when the mass ratio of the prothioconazole to the metalaxyl-M is 2: 1-1: 1, the composition shows synergistic effect on the corn root rot; the rest of the mixture ratio shows additive effect.
Example 2 agent indoor toxicity test on maize grubs
The tested pests: grub larva of corn, breeding in the laboratory
The test method comprises the following steps: testing by adopting a bowl head filled with toxic soil; and configuring a series of concentration gradients for testing. Each treatment was set to 4 replicates. Mortality was checked at 48h, and corrected. Calculating inhibitory concentration of the drug (LC50)
TABLE 2 indoor toxicity of clothianidin and thiamethoxam to grubs
| Medicament | LC50(mg/Kg) | Confidence interval |
| Clothianidin | 27.585 | 20.821-35.107 |
| Thiamethoxam | 63.136 | 30.557-114.233 |
As shown in the table 2, both clothianidin and thiamethoxam can be used for controlling corn grubs, and the biological activity of clothianidin is obviously higher than that of thiamethoxam.
Example 3 indoor bacteriostatic test of ternary complex medicament on rhizoctonia solani
See example 1 for specific test methods
TABLE 3 synergistic Effect of three-component combinations of chemical Corrosion
As can be seen from Table 3, compared with thiamethoxam, the combination of clothianidin and a bactericide (prothioconazole + metalaxyl-M) can obviously improve the control effect of the bactericide on corn root rot.
EXAMPLE 4 formulation
18% prothioconazole, metalaxyl-M and clothianidin suspension seed coating agent
3 percent of prothioconazole
metalaxyl-M3%
Clothianidin 12%
Sodium lignosulfonate 7%
2 percent of undrawn flour
NNO 8％
Polyvinyl alcohol 5%
3 percent of ethylene glycol
1.5 percent of organic silicon
1 percent of rose essence
Deionized water to make up 100%.
30% prothioconazole, metalaxyl-M and clothianidin suspension seed coating agent
6 percent of prothioconazole
metalaxyl-M3%
Clothianidin 21%
Sodium lignosulfonate 6%
4 percent of undaria pinnatifida powder
NNO 5％
Polyvinyl alcohol 4%
Ethylene glycol 4%
2 percent of organic silicon
1.5 percent of rose essence
Deionized water to make up 100%.
24% wettable powder of prothioconazole, metalaxyl-M and clothianidin
8 percent of prothioconazole
metalaxyl-M4%
Clothianidin 12%
Calcium dodecyl benzene sulfonate 8%
5 percent of undaria pinnatifida powder
5 percent of white carbon black
Bentonite makes up to 100%.
Comparative example 1: 6% prothioconazole-metalaxyl-M suspension seed coating agent
3 percent of prothioconazole
metalaxyl-M3%
Sodium lignosulfonate 7%
2 percent of undrawn flour
NNO 8％
Polyvinyl alcohol 5%
3 percent of ethylene glycol
1.5 percent of organic silicon
1 percent of rose essence
Deionized water to make up 100%.
Comparative example 212% Prothioconazole, metalaxyl-M, clothianidin suspension seed coating agent
Clothianidin 12%
Sodium lignosulfonate 7%
2 percent of undrawn flour
NNO 8％
Polyvinyl alcohol 5%
3 percent of ethylene glycol
1.5 percent of organic silicon
1 percent of rose essence
Deionized water to make up 100%.
Example 5 field control of corn pests with the Compound formulation
The test method comprises the following steps: the artificial inoculation is adopted. Seed coating treatment was repeated 4 times, and the cells were randomized in blocks.
Disease investigation and statistics: sampling at 5 points in each plot 30d after the emergence of the corn seedlings, digging 30 plants in each processing area for investigation, recording the total plant number, the plant number of each stage of diseases and the disease index, and calculating the prevention and treatment effect.
According to the corn infection condition, the corn is divided into the following grades: grade 0, namely the base of the plant stem, the main and fibrous roots have no disease spots; grade 1, a small amount of scabs are on the base of the stem and the main root; grade 3, the base part of the stem and the main root have more scabs, and the area of the scabs accounts for 1/4-1/2 of the total area of the stem and the root; grade 5, the disease spots on the stem base and the main root are more and larger, and the area of the disease spots accounts for 1/2-3/4 of the total area of the stem base and the root; 7, connecting the base of the stem and the lesion on the main root to form a stem winding phenomenon, but the root system does not die; grade 9, root necrosis, wilting or death of the overground part of the plant.
TABLE 4 field control of corn diseases by suspended seed coating
As can be seen from Table 2: the dosage of the suspension seed coating agent prepared by the invention is 400-500ml/100kg of seeds, the corn diseases and insect pests can be effectively controlled, and the control effect is more than 90%. And field observation shows that the fertilizer is safe for corn crops.
While the foregoing is directed to embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow.
Claims (7)
1. A seed treatment agent is characterized by comprising prothioconazole, metalaxyl-M and clothianidin in a weight ratio of 1-5: 1-20.
2. The seed treatment agent according to claim 1, characterized in that the weight ratio of prothioconazole, metalaxyl-M and clothianidin is 1-2: 1-10.
3. The seed treatment agent according to any one of claims 1 to 2, wherein the dosage form of the seed treatment agent is suspension seed coating agent, wettable powder and water dispersible granule.
4. The seed treatment agent according to claim 3, wherein the percentage of the active ingredient is 10% to 65%.
5. Use of a seed treatment according to any one of claims 1 to 4 for controlling crop pests.
6. The use according to claim 5, the crop being peanut, soybean, corn.
7. The use according to claim 6, wherein the disease is root rot and the pest is grub.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110446578.XA CN113142232A (en) | 2021-04-22 | 2021-04-22 | Seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110446578.XA CN113142232A (en) | 2021-04-22 | 2021-04-22 | Seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN113142232A true CN113142232A (en) | 2021-07-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110446578.XA Pending CN113142232A (en) | 2021-04-22 | 2021-04-22 | Seed treatment agent containing prothioconazole, metalaxyl-M and clothianidin and application thereof |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101087526A (en) * | 2004-12-24 | 2007-12-12 | 拜尔农作物科学股份公司 | Synergistic mixtures exhibiting insecticidal and fungicidal action |
| WO2012117572A1 (en) * | 2011-03-01 | 2012-09-07 | Sumitomo Chemical Company, Limited | Pest controlling composition and method for controlling pests |
| CN103238618A (en) * | 2013-04-15 | 2013-08-14 | 海利尔药业集团股份有限公司 | Seed treating agent composition containing clothianidin |
| US20140200140A1 (en) * | 2013-12-30 | 2014-07-17 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| US20150094203A1 (en) * | 2013-10-01 | 2015-04-02 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| CN104621129A (en) * | 2013-11-15 | 2015-05-20 | 南京华洲药业有限公司 | Sterilization composition containing prothioconazole and metalaxyl-M and application thereof |
| US20150157017A1 (en) * | 2013-12-06 | 2015-06-11 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| CN105394048A (en) * | 2015-12-19 | 2016-03-16 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing prothioconazole and efficient metalaxyl-M |
-
2021
- 2021-04-22 CN CN202110446578.XA patent/CN113142232A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101087526A (en) * | 2004-12-24 | 2007-12-12 | 拜尔农作物科学股份公司 | Synergistic mixtures exhibiting insecticidal and fungicidal action |
| WO2012117572A1 (en) * | 2011-03-01 | 2012-09-07 | Sumitomo Chemical Company, Limited | Pest controlling composition and method for controlling pests |
| CN103238618A (en) * | 2013-04-15 | 2013-08-14 | 海利尔药业集团股份有限公司 | Seed treating agent composition containing clothianidin |
| US20150094203A1 (en) * | 2013-10-01 | 2015-04-02 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| CN104621129A (en) * | 2013-11-15 | 2015-05-20 | 南京华洲药业有限公司 | Sterilization composition containing prothioconazole and metalaxyl-M and application thereof |
| US20150157017A1 (en) * | 2013-12-06 | 2015-06-11 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| US20140200140A1 (en) * | 2013-12-30 | 2014-07-17 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| CN105394048A (en) * | 2015-12-19 | 2016-03-16 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing prothioconazole and efficient metalaxyl-M |
Non-Patent Citations (1)
| Title |
|---|
| 马安民 等: "《园林植物杀菌剂应用技术》", 31 October 2016, 河南科学技术出版社 * |
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Application publication date: 20210723 |