CN113142073A - Multifunctional integrated cage for experimental non-human primates and use method thereof - Google Patents
Multifunctional integrated cage for experimental non-human primates and use method thereof Download PDFInfo
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- CN113142073A CN113142073A CN202110526594.XA CN202110526594A CN113142073A CN 113142073 A CN113142073 A CN 113142073A CN 202110526594 A CN202110526594 A CN 202110526594A CN 113142073 A CN113142073 A CN 113142073A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/0005—Stable partitions
- A01K1/0017—Gates, doors
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
- A01K1/0356—Feeding or drinking devices associated with cages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K15/00—Devices for taming animals, e.g. nose-rings or hobbles; Devices for overturning animals in general; Training or exercising equipment; Covering boxes
- A01K15/02—Training or exercising equipment, e.g. mazes or labyrinths for animals ; Electric shock devices ; Toys specially adapted for animals
- A01K15/027—Exercising equipment, e.g. tread mills, carousels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
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- Clinical Laboratory Science (AREA)
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Abstract
The invention relates to a multifunctional integrated cage for experimental non-human primates and a using method thereof, and the multifunctional integrated cage comprises a cage body, wherein the left side surface of the cage body is provided with an animal entrance gate, the front side surface of the cage body is a transparent plate, the rear side surface of the cage body is a background plate, and the top surface of the cage body is provided with a transverse holding rod area, a longitudinal holding rod area and an oblique holding rod area; the transverse holding rod area consists of a plurality of holding rods which are transversely distributed; the longitudinal holding rod area consists of a plurality of holding rods which are longitudinally distributed; the inclined holding rod area consists of a plurality of holding rods which are distributed in an inclined way; the top surface can also be detachably distributed with a rack assembly; the left side surface and the right side surface of the cage body are respectively provided with a plurality of food taking ports; an adjustable hanging rack component is also distributed on the outer side corresponding to the food taking port. The integrated cage can provide various ethology test functions and functions of video recording, feeding monitoring and the like, and has accurate, scientific and reliable data acquisition and good use effect.
Description
Technical Field
The invention relates to the technical field of non-human primate experimental animal multifunctional cages, in particular to a non-human primate experimental animal multifunctional integrated cage and a using method thereof.
Background
After a non-human primate experimental animal (hereinafter referred to as an experimental animal) is subjected to relevant modeling, relevant indexes such as behaviours and the like, for example, diabetic monkeys or senile dementia disease model monkeys generally need to be recorded or recorded, and during the experiment, the relevant limb fine activity indexes of the experimental animal need to be evaluated so as to judge the recovery condition of the experimental animal after the experimental animal uses relevant drugs. For example, the smoothness of the movement of the joints of limbs, fingers and the like is difficult to realize, because the experimental animal cannot directly communicate with human beings, the objective evaluation has technical difficulties at present, and particularly, the behavioral activity capability/level of the experimental animal naturally reflected by the experimental animal is obtained under the condition that the experimental animal is not influenced by any external human, so that the objective and accurate evaluation is realized, which is more difficult to solve at present. The behavioral evaluation generally involves video recording and shooting, and the video recording and shooting are generally performed with automatic analysis through software, but the current relevant video acquisition cage has a great defect, and mainly the current software is difficult to effectively distinguish the limb actions of part of animals in the video, so that the relevant video cannot be automatically analyzed. Meanwhile, for example, diabetic monkeys need to record indexes such as water intake and urine output in addition to behavioral evaluation, and it is found that the collection of related data is best in an environment familiar to experimental animals, after all, the mental states (such as impatience) of the experimental animals in a new environment are abnormal, and the collection of objective data is not facilitated, so that the cage integrating multiple functions of feeding, behavioral testing and video recording is necessary.
Disclosure of Invention
Aiming at the technical problems, the invention provides a multifunctional integrated cage for the experimental non-human primates, which can provide a multifunctional function integrating a behavioristics test function and video recording and has a good use effect, and a use method thereof.
In order to achieve the aim, the invention adopts the following technical scheme:
a multifunctional integrated cage for experimental non-human primates comprises a cage body, wherein an animal entrance and exit gate is arranged on the left side surface of the cage body, the front side surface of the cage body is a transparent plate, the rear side surface of the cage body is a background plate, and the top surface of the cage body is provided with a transverse holding rod area, a longitudinal holding rod area and an oblique holding rod area; the transverse holding rod area consists of a plurality of holding rods which are transversely distributed; the longitudinal holding rod area consists of a plurality of holding rods which are longitudinally distributed; the inclined holding rod area consists of a plurality of holding rods which are distributed in an inclined way; the top surface can also be detachably distributed with a rack assembly; the left side surface and the right side surface of the cage body are respectively provided with a plurality of food taking ports; an adjustable hanging rack component is also distributed on the outer side corresponding to the food taking port.
Furthermore, the rack assembly comprises two rack fixing seats and a rack; a plurality of fixing holes are formed in the bottom plate of the rack fixing seat, and a fixing slot is formed in the middle of the rack fixing seat; the whole rack is in a 7 shape, and the inclined sides of the rack are sequentially provided with a first layer inclined plate, a horizontal layer plate and a second layer inclined plate from bottom to top; the first layer of inclined plate, the horizontal laminate and the second layer of inclined plate are respectively provided with a plurality of food jacks; the two ends of the rack are correspondingly inserted into the rack fixing seats to realize detachable fixing; the two rack fixing seats are respectively fixed on the left side and the right side of the top surface of the cage body.
Further, the adjustable hanger assembly comprises a hanger fixing seat and a hanger; the middle part of the fixed seat of the hanging rack is provided with a longitudinal slot; fixing holes are formed in two sides of the longitudinal slot; the hanger comprises a 7-shaped socket and a 7-shaped adjustable hanger; the sockets are detachably distributed in the longitudinal slots; the upper side of the socket is also provided with a locking bolt; an adjusting long groove is formed in the inner side plate surface of the adjusting storage rack corresponding to the locking bolt; the adjusting long grooves are inserted into the locking bolts and movably distributed and are tightly pressed and fixed by the locking bolts; a plurality of food jacks are arranged on the upper edge of the outer side plate surface of the adjustable storage rack in the inner and outer directions.
Furthermore, the upper plate surface of the socket is also provided with scales which are distributed corresponding to the adjusting long grooves.
Furthermore, the background plate is a milky background plate, and an LED lamp strip is arranged in the background plate. Further, the width and height of the background plate are larger than those of the front side surface. Furthermore, a memory test board fixing slot is correspondingly arranged at the position of the animal entrance and exit gate. The method for detecting the behavioral exercise capacity of the multifunctional integration cage for the experimental non-human primates comprises the following steps:
(1) limiting the feeding of the experimental animals to be detected, which are raised in the cage bodies, by one meal in advance;
(2) a video recorder is set up, and the maximum shooting picture is in the range of the background plate;
(3) adjusting the telescopic length of the adjustable shelf relative to the socket as required, tightening the locking bolt for fixing, and then inserting the food jacks on the shelf and the adjustable shelf with long-strip food respectively;
(4) after the video recording is started, the rack and the hanger are correspondingly inserted into the rack fixing seat and the hanger fixing seat respectively, and then a technician immediately leaves the periphery of the cage body;
(5) the animal to be tested naturally shows the actions of coordination of limbs, climbing, upward pulling of arms and grabbing under the attraction of the long-strip food, so that the real activity of joints and fingers of the animal to be tested is obtained.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, the milky white background plate containing the LED is arranged, so that the contrast between the limbs of the experimental animal and the background plate can be enhanced in the video monitoring process, and the identification of the limbs of the experimental animal and the acquisition effect of the definition are obviously improved.
(2) The food taking openings are respectively arranged on the left side surface and the right side surface of the cage body; the adjustable shelf component is also distributed on the outer side corresponding to the food taking opening, the adjustable shelf component can adjust the telescopic length as required, so that when experimental animals are monitored from the side to obtain foods with different heights and different distances, natural upper limb movement and finger grabbing fine action conditions which are really free of human factor interference are facilitated, objective comparison before disease modeling, after disease modeling and during drug treatment is facilitated, and objective evaluation is facilitated.
(3) The invention is provided with a transverse holding rod area, a longitudinal holding rod area and an oblique holding rod area, and is provided with a rack assembly in a matching way, and meanwhile, the rack assembly is correspondingly and sequentially provided with three material taking layers, namely a first layer inclined plate, a horizontal layer plate and a second layer inclined plate; the food on the three material taking layers can realize the attraction of three gradient foods, so that the experimental animal is prompted to hold the holding rod area by itself to be in a suspension state, and the limb activity condition of the experimental animal can be evaluated; then attracting and correspondingly grabbing food of the first layer of inclined plate which is gradually inclined upwards in the transverse holding rod area, and obtaining the coordination capacity condition of limbs and the grabbing capacity evaluation of the food which is gradually changed to be higher; the experimental animal can directly obtain the evaluation of the 90-degree and other-angle conversion grabbing capacity and the joint movement capacity of the experimental animal when the experimental animal is converted from the transverse holding rod area to the longitudinal holding rod area and then is converted to the oblique holding rod area; and the higher second-layer inclined plate food can shoot the action of grabbing the longer limbs outside the cage, so that the grabbing difficulty is gradually improved, the relative action and activity ability indexes can be obtained more visually through testing, and the required behavioural data can be obtained more visually, objectively and accurately.
Drawings
FIG. 1 is a schematic structural view of a cage of the present invention;
FIG. 2 is a schematic structural view of an adjustable hanger assembly of the present invention;
figure 3 is a schematic diagram of a hanger in accordance with the present invention;
figure 4 is a schematic diagram of a hanger holder assembly according to the present invention;
fig. 5 is a schematic view of the fully assembled structure of the present invention.
Detailed Description
As shown in fig. 1 to 5, a multifunctional integrated cage for experimental non-human primates comprises a cage body, wherein an animal entrance and exit gate is formed on a left side surface 3 of the cage body, a memory test board fixing slot 4 is further correspondingly formed in the animal entrance and exit gate in the embodiment, namely, a rectangular dragging iron door is arranged at ordinary times for transferring animals to enter the cage body and then inserting and fixing the animals, when a behavior memory ability test is required, a currently universal related test board is correspondingly inserted into the memory test board fixing slot 4, and the dragging iron door is pulled out for testing. The leading flank 1 of the cage body is the transparent plate, can adopt glass or ya keli material to support, and trailing flank 9 is the background board, this embodiment the background board is milky white background board, and its inside still is equipped with LED lamp area for provide soft light, be favorable to improving the contrast in the video recording video and better present relevant microscopic action details, this embodiment the width of background board, height size are greater than the width of leading flank, height size are convenient for in the video recording video, and laboratory animal's home range all is in within this background board, does benefit to follow-up software's autoanalysis, excellent in use effect. The top surface of the cage body is provided with a transverse holding rod area 6, a longitudinal holding rod area 7 and an oblique holding rod area 8; the transverse holding rod area 6 consists of a plurality of holding rods which are transversely distributed; the longitudinal holding rod area 7 consists of a plurality of holding rods which are longitudinally distributed; the inclined holding rod area 8 consists of a plurality of holding rods which are distributed in an inclined manner, and the three holding rod areas are arranged for testing the conversion of the holding rod direction of the experimental animal in the processes of climbing and holding rod hanging, visually evaluating the joint mobility of the experimental animal and the like; the top surface can also be detachably distributed with a rack assembly; the left side surface and the right side surface of the cage body are respectively provided with a plurality of food taking openings 5; an adjustable hanging rack component is also distributed on the outer side corresponding to the food taking port 5.
The hanger assembly of the present embodiment includes two hanger holders 26 and a hanger; a plurality of fixing holes 28 are arranged on the bottom plate of the rack fixing seat 26, and a fixing slot 27 is arranged in the middle of the rack fixing seat; the whole rack is in a 7 shape, and the inclined sides of the rack are sequentially provided with a first layer inclined plate 19, a horizontal layer plate 22 and a second layer inclined plate 23 from bottom to top; the first layer of inclined plate 19, the horizontal layer plate 22 and the second layer of inclined plate 23 are respectively provided with a plurality of food jacks 21; the two ends 20 and 25 of the rack are correspondingly inserted into the rack fixing seats to realize detachable fixation, in the embodiment, the stability of the fixation of the rack is better realized, the two ends can be made of silica gel or rubber materials, the friction force is improved, and the phenomena of shaking and the like in the using process, particularly in the animal feeding process are prevented; two rack fixing seats 26 are fixed on the left and right sides of the top surface of the cage body, respectively.
The adjustable hanger assembly of the present embodiment comprises a hanger fixing base 10 and a hanger; the middle part of the hanger fixing seat 10 is provided with a longitudinal slot 12; fixing holes 11 are formed in two sides of the longitudinal slot 12, and when the cage is used, the cage is fixed to the cage body through U-shaped bolts or iron wires penetrating through the fixing holes 11; the hanger comprises a 7-shaped socket 13 and a 7-shaped adjusting hanger 14; the sockets 13 are detachably distributed in the longitudinal slots 12; the upper side of the socket 13 is also provided with a locking bolt 16; an adjusting elongated slot 15 is formed on the inner side plate surface of the adjusting article placing rack 14 corresponding to the locking bolt; the adjusting long grooves 15 are inserted into the locking bolts 16 and movably distributed and are pressed and fixed by the locking bolts 16, namely the adjusting object placing rack 14 is telescopically adjusted according to the age of the experimental animal and the requirement so as to change the relative distance between food and the experimental animal, which is also used for detecting the limb coordination ability of the experimental animal; the outer side plate face of the adjusting shelf 14 is provided with food fixing lugs 17, a plurality of food insertion holes 18 are formed in the inner and outer directions of the upper edges of the food fixing lugs 17, and when the food adjusting shelf is used, strip-shaped food such as sweet potato strips, hawthorn strips, apple strips and the like are inserted into the food insertion holes 18. Of course, in order to improve the accuracy, scales may be further disposed on the upper plate surface of the socket 13, and the scales are distributed corresponding to the adjustment elongated slots.
Certainly, for example, aiming at diabetic monkeys, a special urine amount accurate collecting device, a water drinking device with the function of accurately measuring the water drinking amount of the non-human primate experimental animals and the like can be integrated on the cage body according to needs, so that the integration level is high, and the using effect is good.
The method for detecting the behavioral exercise capacity of the multifunctional integration cage for the experimental non-human primates comprises the following steps:
(1) limiting the feeding of the experimental animals to be detected, which are raised in the cage bodies, by one meal in advance;
(2) a video recorder is set up, and the maximum shooting picture is in the range of the background plate;
(3) adjusting the telescopic length of the adjustable shelf relative to the socket as required, tightening the locking bolt for fixing, and then inserting the food jacks on the shelf and the adjustable shelf with long-strip food respectively;
(4) after the video is started, the rack and the hanger are correspondingly inserted into the rack fixing seat and the hanger fixing seat respectively, and then a technician immediately leaves the periphery of the cage body (in order to form an environment without artificial interference at the periphery or influence on the mental state of the experimental animal, so that the experimental animal can be prompted to more naturally and objectively show the behavioural actions of limbs, joints and the like of the experimental animal, and the required data can be more objectively collected);
(5) the animal to be tested naturally shows the actions of coordination of limbs, climbing, upward arm drawing and grabbing of the animal to be tested under the attraction of the long-strip food, so that the real activity capability of joints and fingers of the animal to be tested (such as the finger flexibility or the resting tremor of upper limbs and the like of diabetic monkeys or senile dementia animal models for grabbing food in different areas and different test situations) is obtained, and accurate and reliable hand information is provided for objective scientific evaluation.
Claims (8)
1. A non-human primate is multi-functional integrated cage for experimental animals which characterized in that: the cage comprises a cage body, wherein an animal entrance and exit gate is arranged on the left side surface of the cage body, the front side surface of the cage body is a transparent plate, the rear side surface of the cage body is a background plate, and the top surface of the cage body is provided with a transverse holding rod area, a longitudinal holding rod area and an oblique holding rod area; the transverse holding rod area consists of a plurality of holding rods which are transversely distributed; the longitudinal holding rod area consists of a plurality of holding rods which are longitudinally distributed; the inclined holding rod area consists of a plurality of holding rods which are distributed in an inclined way; the top surface can also be detachably distributed with a rack assembly; the left side surface and the right side surface of the cage body are respectively provided with a plurality of food taking ports; an adjustable hanging rack component is also distributed on the outer side corresponding to the food taking port.
2. The multifunctional integrated cage for experimental non-human primates as claimed in claim 1, wherein: the rack assembly comprises two rack fixing seats and a rack; a plurality of fixing holes are formed in the bottom plate of the rack fixing seat, and a fixing slot is formed in the middle of the rack fixing seat; the whole rack is in a 7 shape, and the inclined sides of the rack are sequentially provided with a first layer inclined plate, a horizontal layer plate and a second layer inclined plate from bottom to top; the first layer of inclined plate, the horizontal laminate and the second layer of inclined plate are respectively provided with a plurality of food jacks; the two ends of the rack are correspondingly inserted into the rack fixing seats to realize detachable fixing; the two rack fixing seats are respectively fixed on the left side and the right side of the top surface of the cage body.
3. The multifunctional integrated cage for experimental non-human primates as claimed in claim 1, wherein: the adjustable hanger assembly comprises a hanger fixing seat and a hanger; the middle part of the fixed seat of the hanging rack is provided with a longitudinal slot; fixing holes are formed in two sides of the longitudinal slot; the hanger comprises a 7-shaped socket and a 7-shaped adjustable hanger; the sockets are detachably distributed in the longitudinal slots; the upper side of the socket is also provided with a locking bolt; an adjusting long groove is formed in the inner side plate surface of the adjusting storage rack corresponding to the locking bolt; the adjusting long grooves are inserted into the locking bolts and movably distributed and are tightly pressed and fixed by the locking bolts; a plurality of food jacks are arranged on the upper edge of the outer side plate surface of the adjustable storage rack in the inner and outer directions.
4. The multifunctional integration cage for experimental non-human primates as claimed in claim 3, wherein: the upper plate surface of the socket is also provided with scales which are distributed corresponding to the adjusting long grooves.
5. The multifunctional integrated cage for experimental non-human primates as claimed in claim 1, wherein: the background plate is a milky background plate, and an LED lamp strip is arranged in the background plate.
6. The multifunctional integrated cage for experimental non-human primates as claimed in claim 1, wherein: the width and height of the background plate are larger than those of the front side surface.
7. The multifunctional integrated cage for experimental non-human primates as claimed in claim 1, wherein: and a memory test board fixing slot is correspondingly arranged at the animal entrance and exit gate.
8. The method for detecting the behavioral performance of the multifunctional integration cage for the experimental non-human primates according to any one of claims 1 to 7, comprising the following steps:
(1) limiting the feeding of the experimental animals to be detected, which are raised in the cage bodies, by one meal in advance;
(2) a video recorder is set up, and the maximum shooting picture is in the range of the background plate;
(3) adjusting the telescopic length of the adjustable shelf relative to the socket as required, tightening the locking bolt for fixing, and then inserting the food jacks on the shelf and the adjustable shelf with long-strip food respectively;
(4) after the video recording is started, the rack and the hanger are correspondingly inserted into the rack fixing seat and the hanger fixing seat respectively, and then a technician immediately leaves the periphery of the cage body;
(5) the animal to be tested naturally shows the actions of coordination of limbs, climbing, upward pulling of arms and grabbing under the attraction of the long-strip food, so that the real activity of joints and fingers of the animal to be tested is obtained.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114051943A (en) * | 2021-11-08 | 2022-02-18 | 广东春盛生物科技发展有限公司 | Non-human primate memory ability evaluation system |
| CN115191363A (en) * | 2022-07-12 | 2022-10-18 | 广西医科大学第一附属医院 | Joint movement testing system and testing method for experimental animals |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN115191363A (en) * | 2022-07-12 | 2022-10-18 | 广西医科大学第一附属医院 | Joint movement testing system and testing method for experimental animals |
| CN115191363B (en) * | 2022-07-12 | 2023-05-26 | 广西医科大学第一附属医院 | Joint movement testing system and method for experimental animals |
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| CN113142073B (en) | 2023-05-30 |
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