CN113130289B - Voltage suspension control device, control method and time-of-flight mass spectrometer - Google Patents
Voltage suspension control device, control method and time-of-flight mass spectrometer Download PDFInfo
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- CN113130289B CN113130289B CN201911400197.7A CN201911400197A CN113130289B CN 113130289 B CN113130289 B CN 113130289B CN 201911400197 A CN201911400197 A CN 201911400197A CN 113130289 B CN113130289 B CN 113130289B
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- 239000000725 suspension Substances 0.000 title claims abstract description 50
- 238000000034 method Methods 0.000 title claims abstract description 16
- 230000001133 acceleration Effects 0.000 claims abstract description 133
- 238000002955 isolation Methods 0.000 claims abstract description 66
- 238000006243 chemical reaction Methods 0.000 claims description 38
- 238000005339 levitation Methods 0.000 claims description 27
- 238000007599 discharging Methods 0.000 claims description 16
- 238000012545 processing Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 230000010354 integration Effects 0.000 abstract description 4
- 239000003990 capacitor Substances 0.000 description 14
- 150000002500 ions Chemical class 0.000 description 14
- 238000010586 diagram Methods 0.000 description 8
- 238000001514 detection method Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Abstract
The invention relates to a voltage suspension control device, a control method and a time-of-flight mass spectrometer, wherein the voltage suspension control device comprises the following components: the system comprises a power supply, a control module, an acceleration area, an isolation module and a detector; wherein: the power supply and control module is used for providing a given control signal of the detector voltage and a given control signal of the acceleration region voltage; the acceleration region is used for generating an acceleration region output voltage according to a control signal given by the acceleration region voltage; the isolation module is used for isolating the given control signal of the detector voltage and generating the given isolated control signal of the detector voltage; the detector is used for generating a first voltage of the detector according to a given isolation control signal of the voltage of the detector, the grounding end of the detector is connected with the output end of the acceleration region, the output voltage of the detector is a suspension superposition voltage of the first voltage of the detector and the output voltage of the acceleration region, and independent and flexible control and integration of the voltage of the acceleration region and the voltage of the detector are realized.
Description
Technical Field
The invention relates to the field of mass spectrometry, in particular to a voltage suspension control device, a control method and a time-of-flight mass spectrometer.
Background
Mass spectrometry technology has been widely used in chemical analysis since the invention in the last century because of its high sensitivity and direct mass measurement characteristics. Among them, time-of-FLIGHT MASS Spectrometer (TOFMS) is one of the most commonly used mass analyzers, and compared with other types of mass analyzers, has the advantages of microsecond detection speed, high resolution, high sensitivity, high mass accuracy, high mass upper limit and the like, and is very suitable for being used together with normal pressure ionization technology.
The core of the mass analysis area in the TOFMS mainly comprises a pulse modulation area, an acceleration area, a reflection area and a detector, and each part is added with a special high-voltage direct-current potential to form a special ion flight transmission electric field.
When the TOFMS of the time-of-flight mass spectrometer works, a high enough voltage is required to be added to an acceleration area so that ions have enough kinetic energy to start to move, and a higher acceleration voltage is required to be added to high-quality ions, so that the ion impact force is increased, and higher detection efficiency is obtained. Meanwhile, enough high voltage needs to be added to two ends of the detector to ensure that the detector can work normally and has enough current amplification gain. Therefore, the accelerating area and the detector are required to be powered on independently, the voltage is flexible and adjustable, the high voltage of the accelerating area can be flexibly switched to the polarity of positive ions and negative ions, meanwhile, the reference potential of the detector and the potential of the high voltage of the accelerating area are equipotential, and the high voltage applied to the detector is required to be suspended and overlapped on the high voltage of the accelerating area.
The high pressure of the detector is required to be suspended and overlapped on the high pressure of a very high acceleration area, and the detector and the high pressure are required to be independently operated and flexibly adjustable, so that the high pressure detector has quite great difficulty in the practical realization of engineering technology.
Disclosure of Invention
Based on the above, it is necessary to provide a voltage suspension control device, a control method and a time-of-flight mass spectrometer, aiming at the problems that the high voltage of the current detector needs to be suspended and overlapped on the high voltage of a very high acceleration area, and the high voltage of the current detector needs to be independent and flexible and adjustable, which has considerable difficulty in the practical realization of engineering technology.
A voltage levitation control apparatus comprising: the system comprises a power supply, a control module, an acceleration area, an isolation module and a detector; wherein:
the power supply and control module is used for providing a detector voltage given control signal and an acceleration area voltage given control signal and providing power supply for the voltage suspension control device;
The acceleration region is used for generating an acceleration region output voltage according to the acceleration region voltage given control signal;
The isolation module is used for isolating the given detector voltage control signal and generating the given detector voltage isolation control signal according to the given detector voltage control signal;
The detector is used for generating a detector first voltage according to the detector voltage given isolation control signal, the grounding end of the detector is connected with the output end of the acceleration region, and the output voltage of the detector is a suspension superposition voltage of the detector first voltage and the output voltage of the acceleration region.
In one embodiment, the isolation module comprises a first isolation linear module and a second isolation linear module, and the voltage suspension control device further comprises a first digital-to-analog conversion module and a first analog-to-digital conversion module; wherein:
The first digital-to-analog conversion module is used for carrying out digital-to-analog conversion on the detector voltage given control signal to generate a detector voltage given analog control signal;
The first isolation linear module is used for performing isolation and linear processing on the detector voltage given control analog signal to generate the detector voltage given isolation control signal, and the detector generates a detector first voltage according to the detector voltage given isolation control signal;
The second isolation linear module is used for performing isolation and linear processing on the output voltage of the detector to generate an output voltage feedback isolation signal of the detector;
The first analog-to-digital conversion module is used for performing analog-to-digital conversion on the feedback isolation signal of the output voltage of the detector to generate an output voltage feedback digital signal of the detector;
the power supply and control module is also used for feeding back a digital signal according to the output voltage of the detector and adjusting the given control signal of the voltage of the detector.
In one embodiment, the isolation module further comprises an isolation power supply module, and the voltage levitation control device further comprises a first switch module, wherein:
the first switch module is used for switching off or switching on the working power supply provided by the power supply and control module to the detector;
the isolation power supply module is used for providing an isolation power supply for the detector after the working power supply is isolated.
In one embodiment, the accelerating area comprises an accelerating positive high voltage area and an accelerating negative high voltage area, and the voltage suspension control device further comprises a second switch module, wherein the second switch module is respectively connected with the power supply and the control module, the accelerating positive high voltage area and the accelerating negative high voltage area and is used for selecting one of the accelerating positive high voltage area and the accelerating negative high voltage area to be communicated with the power supply and the control module, so that the output voltage of the accelerating area output by the accelerating area is switched between positive high voltage and negative high voltage.
In one embodiment, the second switching module includes a power switch, a polarity switch, and a first relay connected between the power and control module and the acceleration zone, wherein:
the power switch and the polarity change-over switch are used for cooperatively controlling the first relay to select one of the acceleration positive high voltage region and the acceleration negative high voltage region to be connected with the power supply and the control module.
In one embodiment, the voltage suspension control device further includes a second digital-to-analog conversion module and a second analog-to-digital conversion module, where the second digital-to-analog conversion module is configured to perform digital-to-analog conversion on the acceleration-region voltage given control signal to generate an acceleration-region voltage given analog control signal;
the acceleration region generates an acceleration region output voltage according to the acceleration region voltage given analog control signal;
The second analog-to-digital conversion module is used for performing analog-to-digital conversion on the output voltage of the acceleration region to generate an output voltage feedback digital signal of the acceleration region;
the power supply and control module is also used for feeding back a digital signal according to the output voltage of the acceleration region and adjusting the given control signal of the voltage of the acceleration region.
In one embodiment, the voltage levitation control device further comprises a second relay and a third relay, wherein,
The input end of the second relay is respectively connected with the output end of the acceleration positive high voltage area and the output end of the first relay, and the output end of the second relay is connected with the grounding end of the detector;
the input end of the third relay is respectively connected with the output end of the acceleration negative high voltage area and the output end of the first relay, and the output end of the third relay is connected with the grounding end of the detector.
In one embodiment, the voltage suspension control device further includes a first discharging circuit, where the first discharging circuit is connected to an output end of the accelerating region, and is configured to release charges accumulated in the accelerating positive high voltage region or the accelerating negative high voltage region before a circuit that works at a current moment is to be switched between the accelerating positive high voltage region and the accelerating negative high voltage region, and after a voltage of the accelerating positive high voltage region or the accelerating negative high voltage region drops to a first preset voltage, the second switching module controls the accelerating positive high voltage region and the accelerating negative high voltage region to perform switching.
In one embodiment, the voltage suspension control device further includes a second discharging circuit, where the second discharging circuit is connected to an output end of the detector, and is configured to release charges accumulated by the detector before the circuit that works at the current moment is switched between the accelerating positive high voltage area and the accelerating negative high voltage area, and after the voltage of the detector drops to a second preset voltage, the second switching module controls the accelerating positive high voltage area and the accelerating negative high voltage area to perform switching.
In one embodiment, the voltage suspension control device further includes a first filter circuit, where the first filter circuit is connected to the output end of the accelerating positive high voltage area and the output end of the accelerating negative high voltage area, and is used to filter the output voltage of the accelerating positive high voltage area or the accelerating negative high voltage area.
In one embodiment, the voltage suspension control device further includes a second filter circuit, where the second filter circuit is connected to the output end of the detector, and is configured to filter the output voltage of the detector.
A voltage levitation control method, comprising:
acquiring a detector voltage given control signal and an acceleration region voltage given control signal;
Generating an acceleration region output voltage according to the acceleration region voltage given control signal;
Isolating the detector voltage given control signal to generate a detector voltage given isolation control signal;
generating a detector first voltage from the detector voltage given an isolation control signal;
And carrying out suspension superposition on the first voltage of the detector and the output voltage of the acceleration region to obtain the output voltage of the detector.
A time-of-flight mass spectrometer comprising a voltage suspension control device as described above.
According to the voltage suspension control device, the control method and the time-of-flight mass spectrometer, the detector voltage given control signals provided by the power supply and the control module are isolated through the isolation module, the detector generates the first voltage of the detector according to the isolated control signals, and the ground end of the detector is connected with the output end of the acceleration region, so that the output voltage of the detector is the suspension superposition voltage of the first voltage of the detector and the output voltage of the acceleration region, and independent and flexible control and integration of the voltage of the acceleration region and the voltage of the detector are realized.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other embodiments of the drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a voltage suspension control apparatus according to a first embodiment;
FIG. 2 is a schematic diagram of a voltage suspension control apparatus according to a second embodiment;
FIG. 3 is a schematic diagram of a third embodiment of a voltage suspension control apparatus;
fig. 4 is a schematic diagram of a voltage levitation control apparatus of a fourth embodiment;
fig. 5 is a schematic view of a voltage levitation control apparatus of a fifth embodiment;
fig. 6 is a schematic diagram of a voltage levitation control apparatus of a sixth embodiment;
fig. 7 is a schematic diagram of a voltage levitation control apparatus of a seventh embodiment;
fig. 8 is a schematic diagram of a voltage levitation control apparatus of an eighth embodiment;
Fig. 9 is a schematic view of a voltage levitation control apparatus of a ninth embodiment;
Fig. 10 is a schematic view of a voltage levitation control apparatus of a tenth embodiment;
fig. 11 is a schematic flow chart of a voltage suspension control method according to an embodiment of the invention.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
As shown in fig. 1, a schematic diagram of a voltage suspension control device according to an embodiment of the present invention is provided, where the voltage suspension control device may specifically include: a power and control module 100, an acceleration zone 200, an isolation module 300, a detector 400; wherein:
The power and control module 100 is configured to provide a detector voltage set control signal and an acceleration zone voltage set control signal, and to provide power to the voltage levitation control device.
The acceleration region 200 is configured to generate an acceleration region output voltage according to the acceleration region voltage given control signal.
The isolation module 300 is configured to isolate the detector voltage given control signal and generate a detector voltage given isolated control signal based on the detector voltage given control signal.
The detector 400 is configured to generate a detector first voltage according to the detector voltage given isolation control signal, and the ground terminal of the detector 400 is connected to the output terminal of the acceleration region 200, so that the output voltage of the detector 400 is a floating superposition voltage of the detector first voltage and the output voltage of the acceleration region 200.
According to the voltage suspension control device provided by the embodiment, the power supply and the detector voltage provided by the control module are isolated by the isolation module, the detector generates the first voltage of the detector according to the isolated control signal, and the ground end of the detector is connected with the output end of the acceleration region, so that the output voltage of the detector is the suspension superposition voltage of the first voltage of the detector and the output voltage of the acceleration region, and independent and flexible control and integration of the voltage of the acceleration region and the voltage of the detector are realized.
In one embodiment, when detecting the positive ion mode, the first voltage of the detector is 0 to +2000V and is overlapped on the high voltage of the acceleration area by 0 to-5000V in a suspending way; when the negative ion mode is detected, the first voltage of the detector is 0 to +2000V, and is suspended and overlapped on the high voltage of the acceleration area by 0 to +5000V.
In one embodiment, as shown in fig. 2, the isolation module 300 may specifically include a first isolation linear module 310 and a second isolation linear module 320, and the voltage suspension control apparatus further includes a first digital-to-analog conversion module 500 and a first analog-to-digital conversion module 600; wherein:
the first digital-to-analog conversion module 500 is configured to perform digital-to-analog conversion on the detector voltage given control signal to generate a detector voltage given analog control signal.
The first isolation linear module 310 is configured to perform isolation and linear processing on the above-mentioned detector voltage-given control analog signal, and generate a detector voltage-given isolation control signal, from which the detector 400 generates a detector first voltage. In one embodiment, when the first digital-to-analog conversion module 500 outputs 0-10V, the first voltage corresponding to the detector 400 is 0 to +2000V.
The second isolation linear module 320 is configured to perform isolation and linear processing on the output voltage of the detector 400, and generate an output voltage feedback isolation signal of the detector 400.
The first analog-to-digital conversion module 600 is configured to perform analog-to-digital conversion on the feedback isolation signal of the output voltage of the detector to generate an output voltage feedback digital signal of the detector 400.
The power supply and control module 100 is further configured to feed back a digital signal according to an output voltage of the detector 400, adjust a given control signal of the detector voltage, and further adjust the output voltage of the detector 400.
In one embodiment, as shown in fig. 3, the isolation module further includes an isolation power supply module 330, and the voltage levitation control device further includes a first switch module 700, where:
The first switching module 700 is used to turn off or on the operating power supplied to the detector 400 by the control module 100.
The isolation power supply module 330 is configured to provide an isolated power supply for the detector 400 after performing an isolation process on the working power supply.
In one embodiment, as shown in fig. 4, the acceleration region 200 may specifically include an acceleration positive high voltage region 210 and an acceleration negative high voltage region 220, and the voltage levitation control device further includes a second switch module 800 connected to the power supply and control module 100, the acceleration positive high voltage region 210 and the acceleration negative high voltage region 210, respectively, for selecting one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to be connected to the power supply and control module 100, so that the output voltage of the acceleration region 200 is switched between the positive high voltage and the negative high voltage.
In one embodiment, as shown in fig. 5, the second switch module 800 includes a power switch 820, a polarity switch 840 and a first relay 860, and the power switch 820, the polarity switch 840 and the first relay 860 are connected between the power and control module 100 and the acceleration region 200, wherein: the power switch 820 and the polarity switch 840 are used to cooperatively control the first relay 860 to select one of the positive acceleration high voltage region 210 and the negative acceleration high voltage region 220 to be connected to the power and control module 100.
In one embodiment, as shown in fig. 6, the voltage suspension control apparatus may specifically further include a second digital-to-analog conversion module 900 and a second analog-to-digital conversion module 1000, where the second digital-to-analog conversion module 900 is configured to perform digital-to-analog conversion on the acceleration-zone voltage given control signal to generate the acceleration-zone voltage given analog control signal.
The acceleration region 200 generates an acceleration region output voltage based on the acceleration region voltage given analog control signal. In one embodiment, when the second digital-to-analog conversion module 900 outputs 0-10V, the output voltage of the corresponding acceleration region 500 is 0-5000V.
The second analog-to-digital conversion module 1000 is configured to perform analog-to-digital conversion on the output voltage of the acceleration region to generate an output voltage feedback digital signal of the acceleration region.
The power supply and control module 100 is further configured to feed back a digital signal according to the output voltage of the acceleration region, adjust a given control signal of the acceleration region voltage, and further control the output voltage of the acceleration region.
In one embodiment, as shown in fig. 7, the voltage levitation control apparatus may specifically further include a second relay 1100 and a third relay 1200, wherein,
The input terminal of the second relay 1100 is connected to the output terminal of the acceleration positive high voltage region 210 and the output terminal of the first relay 860, respectively, and the output terminal of the second relay 1100 is connected to the ground terminal of the detector 400. The second relay 1100 is a high voltage relay for selecting one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to be connected to the power and control module 100 in cooperation with the first relay 860.
The input terminal of the third relay 1200 is connected to the output terminal of the acceleration negative high voltage region 220 and the output terminal of the first relay 860, respectively, and the output terminal of the third relay 1200 is connected to the ground terminal of the detector 400. The third relay 1200 is a high voltage relay for selecting one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to be connected to the power and control module 100 in cooperation with the first relay 860.
In one embodiment, as shown in fig. 8, the voltage suspension control apparatus further includes a first discharging circuit 1300, where the first discharging circuit 1300 is connected to the output end of the accelerating region 200, and is used for discharging the charge accumulated in the accelerating positive high voltage region 210 or the accelerating negative high voltage region 220 before the circuit that operates at the current moment is to switch between the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220, and after the voltage of the accelerating positive high voltage region 210 or the accelerating negative high voltage region 220 drops to a first preset voltage, the second switching module 800 controls the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220 to perform switching.
According to the voltage suspension control device provided by the embodiment, the first discharging circuit is used for rapidly releasing charges accumulated in the accelerating positive high-voltage region or the accelerating negative high-voltage region before switching between the accelerating positive high-voltage region and the accelerating negative high-voltage region, and the second switching module is used for controlling the accelerating positive high-voltage region and the accelerating negative high-voltage region to perform rapid switching after the voltage of the accelerating positive high-voltage region or the accelerating negative high-voltage region is reduced to the first preset voltage, so that rapid switching detection of positive ions and negative ions is realized, the research and development period is greatly shortened, and the research and development cost is reduced.
In one embodiment, the first preset voltage may be specifically 0V or a relatively low preset voltage, and the time for executing the switching between the accelerating positive high voltage area and the accelerating negative high voltage area may be completed within 1.5s through the first discharging circuit, so as to realize the fast and stable switching of the polarity.
In one embodiment, as shown in fig. 8, the voltage levitation control apparatus further includes a second discharging circuit 1400, where the second discharging circuit 1400 is connected to the output terminal of the detector 400, and is used to discharge the charge accumulated in the detector 400 before the current circuit is switched between the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220, and after the voltage of the detector drops to a second preset voltage (specifically, may be 0V or a lower preset voltage), the second switching module 800 controls the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220 to perform switching.
The voltage suspension control device provided by the embodiment can realize the rapid and stable polarity switching between the accelerating positive high-voltage region and the accelerating negative high-voltage region through the second discharging circuit, thereby realizing the rapid switching detection of positive ions and negative ions.
In one embodiment, as shown in fig. 8, the voltage suspension control apparatus further includes a first filter circuit 1500, where the first filter circuit 1500 is connected to the output terminal of the positive high voltage accelerating region 210 and the output terminal of the negative high voltage accelerating region 220, and is used for filtering the output voltage of the positive high voltage accelerating region 210 or the negative high voltage accelerating region 220.
In one embodiment, as shown in fig. 8, the voltage suspension control apparatus further includes a second filter circuit 1600, where the second filter circuit 1600 is connected to the output terminal of the detector 400, and is used to filter the output voltage of the detector 400.
In one embodiment, as shown in fig. 9, the first discharging circuit 1300 may specifically include at least one first resistor R1 (the resistance value of each first resistor may be different, and the specific resistance value may be selected according to the actual use scenario), for example, may specifically include five first resistors R1, where one end of each first resistor is connected to the output terminal 210 of the accelerating positive high voltage region and the output terminal 220 of the accelerating negative high voltage region, and the other end is grounded.
In one embodiment, as shown in fig. 9, the second discharging circuit 1400 includes at least one third resistor R3 (the resistance of each third resistor may be different, and the specific resistance may be selected according to the actual use scenario), where one end of each third resistor R3 is connected to the output end of the detector 400, and the other end is grounded.
In one embodiment, as shown in fig. 9, the first filtering circuit 1500 may specifically include a fourth resistor R4, a fifth resistor R5, a first capacitor C1, a second capacitor C2, a third capacitor C3, and a first inductor L1, where the fourth resistor R4, the fifth resistor R5, and the first inductor L1 are sequentially connected in series between the output ends of the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220 and the output end of the first filtering circuit 1500; the first capacitor C1 is connected between the output terminals of the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220 and the ground terminal; the second capacitor C2 is connected between the ground terminal and the connection node of the fourth resistor R4 and the fifth resistor R5; the third capacitor C3 is connected between the connection node of the fifth resistor R5 and the first inductor L1 and the ground terminal.
In one embodiment, the output Gao Yawen waves of the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220 can be controlled within 50mV by the RCL multistage low-pass first filter circuit 1500 consisting of a plurality of resistors, capacitors and inductors, so that the requirement of high resolution of the time-of-flight mass spectrometer is well met.
In one embodiment, as shown in fig. 9, the second filter circuit 1600 includes a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a fourth capacitor C4, a fifth capacitor C5, a sixth capacitor C6, and a second inductor L2, where the sixth resistor R6, the seventh resistor R7, the eighth resistor R8, and the second inductor L2 are sequentially connected in series between the output terminal of the detector 400 and the output terminal of the second filter circuit 1600; the fourth capacitor C4 is connected between the ground terminal and the connection node of the sixth resistor R6 and the seventh resistor R7; the fifth capacitor C5 is connected between the ground terminal and the connection node of the seventh resistor R7 and the eighth resistor R8; the sixth capacitor C6 is connected between the connection node of the eighth resistor R8 and the second inductor L2 and the ground terminal.
In one embodiment, the output Gao Yawen wave of the detector 400 can be controlled within 50mV by the RCL multistage low-pass second filter circuit 1600 consisting of a plurality of resistors, capacitors and inductors, so that the requirement of high resolution of the time-of-flight mass spectrometer is well met.
In one embodiment, as shown in fig. 10, the voltage suspension control apparatus may specifically further include a detector pole piece 1700 and an acceleration region pole piece 1800, where the detector pole piece 1700 is connected to an output end of the detector 400, and the acceleration region pole piece 1800 is connected to an output end of the acceleration region 200; the detector pole piece 1700 and the accelerator region pole piece 1800 are placed in a vacuum chamber. The voltage of the accelerating region pole piece 1800 can be independently and flexibly adjusted and monitored through the accelerating region 200, and the voltage between the detector pole piece 1700 and the accelerating region pole piece 1800 can be independently and flexibly adjusted and monitored through the detector 1700, so that high voltage is effectively applied to the detector 1700, and meanwhile, the independent and flexible adjustment of the ion accelerating kinetic energy and the independent and flexible adjustment of the detector gain are realized.
In one embodiment, the detector may be a Micro channel plate MCP (Micro CHANNEL PLATE), which is an ion detector that is a flat-plate electron multiplier consisting of a number of parallel Micro channels that generate secondary electrons. The performance parameters of the microchannel plate MCP mainly comprise a microchannel aperture d, a microchannel inclination angle theta, a microchannel plate thickness h, a current gain and the like.
The invention also provides a voltage suspension control method which can be applied to a time-of-flight mass spectrometer, as shown in fig. 11, and specifically comprises the following steps:
Step 100: a detector voltage given control signal and an acceleration region voltage given control signal are acquired.
Step 200: and generating an acceleration region output voltage according to the given control signal of the acceleration region voltage.
Step 300: isolating the detector voltage given control signal generates a detector voltage given isolation control signal.
Step 400: a detector first voltage is generated from the detector voltage given an isolation control signal.
Step 500: and carrying out suspension superposition on the first voltage of the detector and the output voltage of the acceleration region to obtain the output voltage of the detector.
According to the voltage suspension control method provided by the embodiment, the detector voltage given control signal is isolated, the detector first voltage is generated according to the detector voltage given isolation control signal, the detector first voltage and the output voltage of the acceleration region are subjected to suspension superposition, the output voltage of the detector is obtained, and independent and flexible control and integration of the acceleration region voltage and the detector voltage are realized.
The voltage suspension control method in this embodiment belongs to the same concept as the voltage suspension control device in the corresponding embodiment in fig. 1, the specific implementation process is detailed in the corresponding device embodiment, and the technical features in the device embodiment are correspondingly applicable in the method embodiment, which is not described herein.
The invention also provides a time-of-flight mass spectrometer which may specifically comprise a voltage suspension control device as described above.
In the present invention, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance; the term "plurality" means two or more, unless expressly defined otherwise. The terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; "coupled" may be directly coupled or indirectly coupled through intermediaries. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
In the description of the present specification, the terms "one embodiment," "some embodiments," "particular embodiments," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (11)
1.A voltage levitation control apparatus, comprising: the system comprises a power supply, a control module, an acceleration area, an isolation module, a detector, a second digital-to-analog conversion module and a second analog-to-digital conversion module; wherein:
the power supply and control module is used for providing a detector voltage given control signal and an acceleration area voltage given control signal and providing power supply for the voltage suspension control device;
The acceleration region is used for generating an acceleration region output voltage according to the acceleration region voltage given control signal;
The isolation module is used for isolating the given detector voltage control signal and generating the given detector voltage isolation control signal according to the given detector voltage control signal;
the detector is used for generating a detector first voltage according to the detector voltage given isolation control signal, the grounding end of the detector is connected with the output end of the acceleration region, and the output voltage of the detector is a suspension superposition voltage of the detector first voltage and the output voltage of the acceleration region;
the second digital-to-analog conversion module is used for carrying out digital-to-analog conversion on the acceleration region voltage given control signal to generate an acceleration region voltage given analog control signal;
the acceleration region generates an acceleration region output voltage according to the acceleration region voltage given analog control signal;
The second analog-to-digital conversion module is used for performing analog-to-digital conversion on the output voltage of the acceleration region to generate an output voltage feedback digital signal of the acceleration region;
The power supply and control module is also used for feeding back a digital signal according to the output voltage of the acceleration region and adjusting a given control signal of the voltage of the acceleration region;
The isolation module comprises a first isolation linear module and a second isolation linear module, and the voltage suspension control device further comprises a first digital-to-analog conversion module and a first analog-to-digital conversion module; wherein: the first digital-to-analog conversion module is used for carrying out digital-to-analog conversion on the detector voltage given control signal to generate a detector voltage given analog control signal; the first isolation linear module is used for performing isolation and linear processing on the detector voltage given control analog signal to generate the detector voltage given isolation control signal, and the detector generates a detector first voltage according to the detector voltage given isolation control signal; the second isolation linear module is used for performing isolation and linear processing on the output voltage of the detector to generate an output voltage feedback isolation signal of the detector; the first analog-to-digital conversion module is used for performing analog-to-digital conversion on the feedback isolation signal of the output voltage of the detector to generate an output voltage feedback digital signal of the detector; the power supply and control module is also used for feeding back a digital signal according to the output voltage of the detector and adjusting the given control signal of the voltage of the detector.
2. The voltage levitation control apparatus of claim 1, wherein the isolation module further comprises an isolated power supply module, the voltage levitation control apparatus further comprising a first switch module, wherein:
the first switch module is used for switching off or switching on the working power supply provided by the power supply and control module to the detector;
the isolation power supply module is used for providing an isolation power supply for the detector after the working power supply is isolated.
3. The voltage levitation control apparatus of claim 2, wherein the acceleration region comprises an acceleration positive high voltage region and an acceleration negative high voltage region, and further comprising a second switching module connected to the power supply and control module, the acceleration positive high voltage region, and the acceleration negative high voltage region, respectively, for selecting one of the acceleration positive high voltage region and the acceleration negative high voltage region to be connected to the power supply and control module so that an acceleration region output voltage output from the acceleration region is switched between a positive high voltage and a negative high voltage.
4. The voltage levitation control of claim 3, wherein the second switching module comprises a power switch, a polarity switch, and a first relay, the power switch, polarity switch, and first relay being connected between the power and control module, the acceleration region, wherein:
the power switch and the polarity change-over switch are used for cooperatively controlling the first relay to select one of the acceleration positive high voltage region and the acceleration negative high voltage region to be connected with the power supply and the control module.
5. The voltage suspension control device of claim 4 further comprising a second relay and a third relay, wherein,
The input end of the second relay is respectively connected with the output end of the acceleration positive high voltage area and the output end of the first relay, and the output end of the second relay is connected with the grounding end of the detector;
the input end of the third relay is respectively connected with the output end of the acceleration negative high voltage area and the output end of the first relay, and the output end of the third relay is connected with the grounding end of the detector.
6. The voltage levitation control apparatus of claim 5, further comprising a first discharging circuit connected to the output terminal of the acceleration region and configured to release the charge accumulated in the acceleration positive high voltage region or the acceleration negative high voltage region before the circuit operating at the current time is to be switched between the acceleration positive high voltage region and the acceleration negative high voltage region, and the second switching module controls the switching between the acceleration positive high voltage region and the acceleration negative high voltage region after the voltage of the acceleration positive high voltage region or the acceleration negative high voltage region drops to a first preset voltage.
7. The voltage levitation control apparatus of claim 6, further comprising a second discharging circuit connected to an output terminal of the detector and configured to discharge charges accumulated by the detector before a circuit operating at a current time is switched between the acceleration positive high voltage region and the acceleration negative high voltage region, and the second switching module controls switching between the acceleration positive high voltage region and the acceleration negative high voltage region after the voltage of the detector drops to a second preset voltage.
8. The voltage levitation control apparatus of claim 7, further comprising a first filter circuit coupled to the output of the accelerating positive high voltage region and the output of the accelerating negative high voltage region for filtering the output voltage of the accelerating positive high voltage region or the accelerating negative high voltage region.
9. The voltage levitation control apparatus of claim 8, further comprising a second filter circuit coupled to the output of the detector for filtering the output voltage of the detector.
10. A voltage levitation control method for controlling a voltage levitation control according to any of claims 1 to 9; the voltage suspension control method comprises the following steps:
acquiring a detector voltage given control signal and an acceleration region voltage given control signal;
Generating an acceleration region output voltage according to the acceleration region voltage given control signal;
Isolating the detector voltage given control signal to generate a detector voltage given isolation control signal;
generating a detector first voltage from the detector voltage given an isolation control signal;
And carrying out suspension superposition on the first voltage of the detector and the output voltage of the acceleration region to obtain the output voltage of the detector.
11. A time-of-flight mass spectrometer comprising a voltage suspension control device as claimed in any one of claims 1 to 9.
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