CN217768292U

CN217768292U - Multistage high-voltage pulse generator and multistage focusing device of time-of-flight mass spectrometer

Info

Publication number: CN217768292U
Application number: CN202221542609.8U
Authority: CN
Inventors: 纪诚; 楚士颖; 崔旭; 徐振; 李书阳; 杨记龙; 程文播
Original assignee: Tianjin Guoke Medical Technology Development Co Ltd
Current assignee: Tianjin Guoke Medical Technology Development Co ltd; Suzhou Institute of Biomedical Engineering and Technology of CAS
Priority date: 2022-06-20
Filing date: 2022-06-20
Publication date: 2022-11-08
Anticipated expiration: 2032-06-20

Abstract

The utility model relates to a multistage high voltage pulse generator and multistage focusing device of time of flight mass spectrograph, this multistage high voltage pulse generator's second high pressure input is connected with the input of first switch spare, the output of first switch spare is connected with first output through first pulse coupling electric capacity, third high pressure input is connected with the input of second switch spare, the output of second switch spare is connected with the second output through second pulse coupling electric capacity, first high pressure input connects at the junction of first pulse coupling electric capacity and first output, first high pressure input connects at the junction of second pulse coupling electric capacity and second output. The utility model discloses expand single impulse generator for multistage impulse generator, through voltage and the duration of adjusting each way impulse generator, realize the multiple focusing to the ion, promoted resolution ratio, solved the measuring problem of mass spectrograph wide range.

Description

Multistage high-voltage pulse generator and multistage focusing device of time-of-flight mass spectrometer

Technical Field

The utility model relates to a high-voltage pulse takes place technical field, in particular to multistage high-voltage pulse generator and multistage focusing device of time of flight mass spectrograph.

Background

Time of Flight Mass spectrometers (TOF) are a very common type of Mass Spectrometer. The mass analyser of such a mass spectrometer is an ion drift tube. Ions generated by the ion source are accelerated into a field-free drift tube and fly at a constant velocity towards an ion receiver. According to the principle that ions with different masses can be separated according to the m/z value, the larger the mass of the ions is, the longer the ions reach the receiver, and the smaller the mass of the ions is, the shorter the ions reach the receiver.

In a time-of-flight mass spectrometer ion source, a high-voltage pulse generator is generally adopted to repel or extract ionized ions, and then the ionized ions enter a time-of-flight mass analyzer for detection, so that the high-voltage pulse generator plays an important role in the time-of-flight mass spectrometer.

Because ions excited by laser have two characteristics of kinetic energy dispersion and position dispersion, the resolution of the time-of-flight mass spectrometer is greatly influenced, the ions can be focused by a single-stage pulse generator at present, but the focusing effect is only once, the pulse voltages and the durations required by the ions with different mass numbers are different, the single focusing cannot meet the requirement of wide-range measurement, and the resolution is limited. Such as: application number is CN201721206264.8, the utility model name is a Chinese patent of high-pressure coupling impulse generator and time of flight mass spectrograph, regards the triode as high-voltage pulse generating device's core component, only can carry out single pulse output, is applied to the mass spectrograph, only can make time of flight mass spectrograph's ion carry out the single focus, can't compromise the ion of different mass sections simultaneously and reach the mass spectrograph performance optimum.

The application number is CN201610430851.9, the utility model name is a Chinese patent of a pulse driving circuit for a high-voltage pull-down pulse generation device, which takes an HTS150 fast switch tube as a core component of the high-voltage pulse generation device, is expensive, and is only matched with a single high-voltage direct-current power supply, and unipolar output is realized. In the main circuit, the output end of the main circuit only has a constant high voltage HVOUT1 and a pulse high voltage HVOUT2, and because the pulse output unit can only output in a single polarity, the HVOUT1 and the HVOUT2 can only have one ion focusing state and can only achieve single focusing.

SUMMERY OF THE UTILITY MODEL

In order to achieve the above objects and other advantages in accordance with the present invention, a first object of the present invention is to provide a multistage high voltage pulse generator, including: first high voltage input end, second high voltage input end, third high voltage input end, first output, second output, first switch spare, second switch spare, first pulse coupling capacitance, second high voltage input end with the input of first switch spare is connected, the output warp of first switch spare first pulse coupling capacitance with first output is connected, third high voltage input end with the input of second switch spare is connected, the output warp of second switch spare second pulse coupling capacitance with the second output is connected, first high voltage input end connects first pulse coupling capacitance with the junction of first output, first high voltage input end connect second pulse coupling capacitance with the junction of second output.

Furthermore, the first switch part and the second switch part are both triodes, the first switch part corresponds to the first triode, and the second switch part corresponds to the second triode.

Further, the power supply device further comprises a first resistor and a second resistor, the base of the first triode is connected with the second high-voltage input end, the emitter of the first triode is grounded through the first resistor, the collector of the first triode is connected with the first output end through the first pulse coupling capacitor, the base of the second triode is connected with the third high-voltage input end, the emitter of the second triode is grounded through the second resistor, and the collector of the second triode is connected with the second output end through the second pulse coupling capacitor.

The first high-voltage input end is connected to the junction of the first pulse coupling capacitor and the first output end through the first protection resistor, and the first high-voltage input end is connected to the junction of the second pulse coupling capacitor and the second output end through the second protection resistor.

Furthermore, the high-voltage power supply further comprises a first input protection resistor, a second input protection resistor and a third input protection resistor, wherein the first high-voltage input end is grounded through the first input protection resistor, the second high-voltage input end is grounded through the second input protection resistor, and the third high-voltage input end is grounded through the third input protection resistor.

Further, the input signals of the first high-voltage input end, the second high-voltage input end and the third high-voltage input end are all direct-current high-voltage input signals.

A second object of the present invention is to provide a time-of-flight mass spectrometer multi-stage focusing device, including: the ion extraction device comprises a multistage high-voltage pulse generator, a target plate and an ion extraction pole, wherein a first output end of the multistage high-voltage pulse generator is connected to the ion extraction pole, and a second output end of the multistage high-voltage pulse generator is connected to the target plate.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model discloses expand single impulse generator for multistage impulse generator, through voltage and the duration of adjusting each way impulse generator, realize having promoted resolution ratio to the multiple focusing of ion, solved the wide measuring problem of mass spectrograph.

The utility model discloses a circuit structure is simple, easily realizes, and core component has only increased high-pressure input and a high-pressure triode of the same kind, alright realize the very big promotion to the mass spectrometer performance to need not to change mechanical structure, just can realize mass spectrometer high-resolution and wide range measurement on original mechanical structure basis.

The above description is only an overview of the technical solution of the present invention, and in order to make the technical means of the present invention clearer and can be implemented according to the content of the description, the following detailed description is made with reference to the preferred embodiments of the present invention and accompanying drawings. The detailed description of the present invention is given by the following examples and the accompanying drawings.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention and do not constitute a limitation on the invention. In the drawings:

fig. 1 is a schematic diagram of a multistage high voltage pulse generator of embodiment 1;

fig. 2 is a schematic view of an ion extraction apparatus of the time-of-flight mass spectrometer of example 2.

Detailed Description

The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that the embodiments or technical features described below can be arbitrarily combined to form a new embodiment without conflict.

Example 1

A multi-stage high voltage pulse generator, as shown in fig. 1, comprising: the high-voltage charging and discharging circuit comprises a first high-voltage input end, a second high-voltage input end, a third high-voltage input end, a first output end, a second output end, a first switching element, a second switching element, a first PULSE coupling capacitor C1 and a second PULSE coupling capacitor C2, wherein an input signal of the first high-voltage input end is a direct-current high-voltage input signal HV-IN-1, an input signal of the second high-voltage input end is a direct-current high-voltage input signal HV-IN-2, an input signal of the third high-voltage input end is a direct-current high-voltage input signal HV-IN-3, an output signal of the first output end is HV-PULSE-1, an output signal of the second output end is HV-PULSE-2, the second high-voltage input end is connected with an input end of the first switching element, an output end of the first switching element is connected with the first output end through the first PULSE coupling capacitor, the third high-voltage input end is connected with an input end of the second switching element, an output end of the second switching element is connected with the second output end through the second PULSE coupling capacitor C1, the second PULSE coupling capacitor C2, charging and discharging voltage of the second switching element is maintained to change. The first high-voltage input end is connected with the joint of the first pulse coupling capacitor and the first output end, and the first high-voltage input end is connected with the joint of the second pulse coupling capacitor and the second output end.

The first switch part and the second switch part are both triodes, the first switch part corresponds to the first triode Q1, and the second switch part corresponds to the second triode Q2.

The multistage high-voltage pulse generator further comprises a first resistor R4 and a second resistor R5, the base of the first triode Q1 is connected with the second high-voltage input end, the emitting electrode of the first triode Q1 is grounded through the first resistor R4, the collecting electrode of the first triode Q1 is connected with the first output end through a first pulse coupling capacitor C1, the base of the second triode Q2 is connected with the third high-voltage input end, the emitting electrode of the second triode Q2 is grounded through the second resistor R5, and the collecting electrode of the second triode Q2 is connected with the second output end through a second pulse coupling capacitor C2.

The multi-stage high-voltage pulse generator further comprises a first protection resistor R6 and a second protection resistor R7, the first high-voltage input end is connected to the joint of the first pulse coupling capacitor C1 and the first output end through the first protection resistor R6, and the first high-voltage input end is connected to the joint of the second pulse coupling capacitor C2 and the second output end through the second protection resistor R7.

In order to ensure that the output value of each high voltage is the high voltage to the ground in the pulse switching process, the high voltage input is maintained to be stable. The multi-stage high-voltage pulse generator further comprises a first input protection resistor R1, a second input protection resistor R2 and a third input protection resistor R3, the first high-voltage input end is grounded through the first input protection resistor R1, the second high-voltage input end is grounded through the second input protection resistor R2, and the third high-voltage input end is grounded through the third input protection resistor R3.

For the upper half circuit of the multi-stage high-voltage pulse generator shown in fig. 1, the working principle is as follows: the working states are two, and the first triode Q1 triggers and does not trigger. When Q1 is not triggered, the resistor R4 is equivalent to an uninserted circuit, the left end of C1 is directly connected with HV-IN-2, the right end of C1 is connected to HV-IN-1 through the resistor R6, the state is a constant state, HV-IN-1 and HV-IN-2 both charge C1, and HV-PULSE-1 is not equal to HV-IN-1 due to the blocking effect of the capacitor. At the moment when the high-voltage triode Q1 is triggered, the left end of the C1 is connected to the left end of the R4, namely, the left end is grounded, the capacitor discharges to the ground through the R4, the potential of the left end of the C1 is reduced to 0, and the potential of the right end of the C1 is correspondingly reduced to HV-IN-2. I.e., HV-PULSE-1= HV-IN-1-HV-IN-2 at the instant the high voltage transistor Q1 is triggered. Through the partial circuit, the control of the on-off of the high-voltage triode Q1 on the output high-voltage PULSE of the HV-PULSE-1 is realized. The control of the high-voltage PULSE signal HV-PULSE-2 is realized by controlling the on-off of the high-voltage triode Q2 in the same way as the lower half part shown in the figure 1.

Example 2

A time-of-flight mass spectrometer multi-stage focusing apparatus, as shown in figure 2, comprising: the ion extraction device comprises a multi-stage high-voltage pulse generator, a target plate 14 and an ion extraction electrode 12, wherein a first output end of the multi-stage high-voltage pulse generator is connected to the ion extraction electrode 12, and a second output end of the multi-stage high-voltage pulse generator is connected to the target plate 14.

In FIG. 2, 11 is a substance to be measured, and 13 is an excited substance. The electric field is formed by changing the voltage of the target plate 14 and the ion extraction electrode 12, so that the flight control and focusing of the ions are realized. The ion extraction device of a time-of-flight mass spectrometer operates in two modes, namely pulsed on and off. To the utility model provides a time-of-flight mass spectrometer that multistage high-voltage pulse generator used, the mode of operation can be manifold. In this embodiment, only one application of the method is described.

HV-PULSE-1 is connected to the ion extraction electrode 12 of the time-of-flight mass spectrometer ion extraction device and HV-PULSE-2 is connected to the target plate 14.HV-IN-1 is positive high voltage, HV-IN-2 is positive high voltage, and HV-IN-3 is negative high voltage. The triggering of the high-voltage triode comprises four stages: in the first stage, Q1 is not triggered, and Q2 is not triggered; the second stage Q1 triggers, Q2 does not trigger; in the third stage, Q1 is not triggered, and Q2 is triggered; the fourth stage Q1 is not triggered and Q2 is not triggered. In this application, HV-PULSE-1 is connected to an ion extraction electrode 12 of a time-of-flight mass spectrometer and HV-PULSE-2 is connected to a target plate 14 of the time-of-flight mass spectrometer. The focusing mode of the ions is described in detail for this application:

in the first stage, Q1 is not triggered and Q2 is not triggered. At this stage, HV-PULSE-1= HV-IN-1, HV-PULSE-2= HV-IN-1, since the potentials of the target plate 14 and the ion extraction electrode 12 are equal, the ions are IN a field-free flight state.

In the second stage, Q1 is triggered and Q2 is not triggered. At this stage, HV-PULSE-1= HV-IN-1-HV-IN-1, HV-PULSE-2= HV-IN-1, the ions are attracted by the force of the electric field and fly towards the ion extraction electrode due to the low voltage at the ion extraction electrode, and the first focusing of the ions is achieved IN conjunction with the first stage.

And in the third stage, Q1 is not triggered, and Q2 is triggered. IN this stage, HV-PULSE-1= HV-IN-1, HV-PULSE-2= HV-IN-1-HV-IN-3, since the voltage of the ion extraction electrode is small, the force of the electric field received by the ions flies toward the ion extraction electrode, and the second focusing of the ions is realized IN combination with the first stage and the second stage.

In the fourth stage, Q1 is not triggered, and Q2 is not triggered. This phase HV-PULSE-1= HV-IN-1, HV-PULSE-2= HV-IN-1, which is a switch recovery state, IN order to keep the switch state consistent for each measurement.

The above embodiment is but one way of applying the multi-stage high voltage pulse generator to a mass spectrometer. It should be understood that the three input high voltages HV-IN-1, HV-IN-2, HV-IN-3 are positive high voltage or negative high voltage and the triggering state of the triode can be modified accordingly according to actual conditions.

The utility model discloses expand single impulse generator for multistage impulse generator, through voltage and the duration of adjusting each way impulse generator, can realize the multiple focusing to the ion, promoted resolution ratio to mass spectrograph wide range measuring problem has been solved. The circuit structure is simple, and easily realization, core component have only increased high-voltage input and a high-voltage triode all the way, alright realize the very big promotion of mass spectrometer performance and need not to change mechanical structure, alright on original mechanical structure basis alright with realize mass spectrometer high-resolution and wide range measurement.

It should also be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrases "comprising one of 8230; \8230;" 8230; "does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.

The embodiments in the present specification are described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments.

The foregoing is merely an example of the present specification and is not intended to limit one or more embodiments of the present specification. Various modifications and alterations to one or more embodiments described herein will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement or the like made within the spirit and principle of one or more embodiments of the present disclosure should be included in the scope of claims of one or more embodiments of the present disclosure. One or more embodiments of this specification.

Claims

1. A multi-stage high voltage pulse generator, comprising: first high voltage input end, second high voltage input end, third high voltage input end, first output, second output, first switch spare, second switch spare, first pulse coupling capacitance, second high voltage input end with the input of first switch spare is connected, the output warp of first switch spare first pulse coupling capacitance with first output is connected, third high voltage input end with the input of second switch spare is connected, the output warp of second switch spare second pulse coupling capacitance with the second output is connected, first high voltage input end connects first pulse coupling capacitance with the junction of first output, first high voltage input end connect second pulse coupling capacitance with the junction of second output.

2. The multi-stage high voltage pulse generator according to claim 1, wherein: the first switch piece and the second switch piece are both triodes, the first switch piece corresponds to the first triode, and the second switch piece corresponds to the second triode.

3. The multi-stage high voltage pulse generator according to claim 2, wherein: still include first resistance and second resistance, the base of first triode with second high voltage input end connects, the projecting pole warp of first triode first resistance ground connection, the collecting electrode warp of first triode first pulse coupling capacitance with first output is connected, the base of second triode with third high voltage input end connects, the projecting pole warp of second triode second resistance ground connection, the collecting electrode warp of second triode second pulse coupling capacitance with the second output is connected.

4. A multi-stage high voltage pulse generator according to claim 3, wherein: the high-voltage power supply further comprises a first protection resistor and a second protection resistor, the first high-voltage input end is connected to the joint of the first pulse coupling capacitor and the first output end through the first protection resistor, and the first high-voltage input end is connected to the joint of the second pulse coupling capacitor and the second output end through the second protection resistor.

5. The multi-stage high voltage pulse generator according to claim 1, wherein: still include first input protection resistance, second input protection resistance, third input protection resistance, first high voltage input end warp first input protection resistance ground connection, second high voltage input end warp second input protection resistance ground connection, third high voltage input end warp third input protection resistance ground connection.

6. The multi-stage high voltage pulse generator according to claim 1, wherein: the input signals of the first high-voltage input end, the second high-voltage input end and the third high-voltage input end are all direct-current high-voltage input signals.

7. A time-of-flight mass spectrometer multi-stage focusing apparatus, comprising: the multi-stage high-voltage pulse generator, the target plate and the ion extraction electrode as claimed in any one of claims 1 to 6, wherein a first output end of the multi-stage high-voltage pulse generator is connected to the ion extraction electrode, and a second output end of the multi-stage high-voltage pulse generator is connected to the target plate.