CN113130289A - Voltage suspension control device, control method and time-of-flight mass spectrometer - Google Patents
Voltage suspension control device, control method and time-of-flight mass spectrometer Download PDFInfo
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- 239000000725 suspension Substances 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims abstract description 15
- 230000001133 acceleration Effects 0.000 claims abstract description 195
- 238000002955 isolation Methods 0.000 claims abstract description 71
- 238000005339 levitation Methods 0.000 claims description 45
- 238000006243 chemical reaction Methods 0.000 claims description 36
- 238000007599 discharging Methods 0.000 claims description 12
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- 238000004458 analytical method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
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- G01N27/622—Ion mobility spectrometry
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- H—ELECTRICITY
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- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply
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- H01J49/00—Particle spectrometers or separator tubes
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Abstract
The invention relates to a voltage suspension control device, a control method and a time-of-flight mass spectrometer, wherein the voltage suspension control device comprises: the device comprises a power supply and control module, an acceleration area, an isolation module and a detector; wherein: the power supply and control module is used for providing a detector voltage given control signal and an acceleration area voltage given control signal; the acceleration region is used for generating an acceleration region output voltage according to an acceleration region voltage given control signal; the isolation module is used for isolating the detector voltage given control signal and generating a detector voltage given isolation control signal; the detector is used for giving an isolation control signal according to the voltage of the detector to generate a first voltage of the detector, the grounding end of the detector is connected with the output end of the acceleration area, the output voltage of the detector is a suspension superposed voltage of the first voltage of the detector and the output voltage of the acceleration area, and independent flexible control and integration of the voltage of the acceleration area and the voltage of the detector are achieved.
Description
Technical Field
The invention relates to the field of mass spectrometry, in particular to a voltage suspension control device, a control method and a time-of-flight mass spectrometer.
Background
Since the invention of the last century, mass spectrometry has been widely used in chemical analysis due to its high sensitivity and direct mass measurement. Among them, the Time-of-Flight Mass Spectrometer TOFMS (Time-of-Flight Mass Spectrometer) is one of the most commonly used Mass analyzers, and compared with other types of Mass analyzers, the Mass Spectrometer TOFMS has the advantages of microsecond detection speed, high resolution, high sensitivity, high Mass precision, high Mass upper limit and the like, and is very suitable for being used with the normal pressure ionization technology.
The core of a mass analysis area in a time-of-flight mass spectrometer TOFMS mainly comprises a pulse modulation area, an acceleration area, a reflection area and a detector, wherein a special high-voltage direct-current potential is added to each part to form a special ion flight transmission electric field.
When the TOFMS works, enough high voltage needs to be added to an acceleration region to enable ions to have enough kinetic energy to start moving, and higher acceleration voltage needs to be added to high-quality ions, so that the ion impact strength is increased, and higher detection efficiency is obtained. Meanwhile, enough high voltage needs to be added to two ends of the detector to ensure that the detector can work normally and has enough current amplification gain. Therefore, the acceleration area and the detector need to be electrified respectively and independently, the voltage is flexible and adjustable, the high voltage of the acceleration area can flexibly switch the polarity aiming at positive and negative ions, meanwhile, the reference potential of the detector and the potential of the high voltage of the acceleration area are equal in potential, and the high voltage applied to the detector needs to be superposed on the high voltage of the acceleration area in a suspension manner.
The high voltage of the detector needs to be suspended and superposed on the high voltage of the acceleration area, and the detector and the high voltage of the acceleration area can work independently and are flexible and adjustable, which has great difficulty in the practical realization of engineering technology.
Disclosure of Invention
Therefore, it is necessary to provide a voltage suspension control device, a control method and a time-of-flight mass spectrometer, which are used for solving the problems that the high voltage of the current detector needs to be suspended and superposed on the high voltage of the acceleration region, and the high voltage of the current detector and the high voltage of the acceleration region need to be capable of realizing independent work and flexible adjustment, and the practical implementation of engineering technology has considerable difficulty.
A voltage levitation control apparatus comprising: the device comprises a power supply and control module, an acceleration area, an isolation module and a detector; wherein:
the power supply and control module is used for providing a detector voltage given control signal and an acceleration area voltage given control signal and providing a power supply for the voltage suspension control device;
the acceleration region is used for generating an acceleration region output voltage according to the acceleration region voltage given control signal;
the isolation module is used for isolating the detector voltage given control signal and generating a detector voltage given isolation control signal according to the detector voltage given control signal;
the detector is used for giving an isolation control signal according to the voltage of the detector to generate a first voltage of the detector, the grounding end of the detector is connected with the output end of the acceleration area, and the output voltage of the detector is the suspension superposition voltage of the first voltage of the detector and the output voltage of the acceleration area.
In one embodiment, the isolation module comprises a first isolation linear module and a second isolation linear module, and the voltage levitation control device further comprises a first digital-to-analog conversion module and a first analog-to-digital conversion module; wherein:
the first digital-to-analog conversion module is used for performing digital-to-analog conversion on the detector voltage given control signal to generate a detector voltage given analog control signal;
the first isolation linear module is used for carrying out isolation and linear processing on the detector voltage given control analog signal to generate a detector voltage given isolation control signal, and the detector generates a detector first voltage according to the detector voltage given isolation control signal;
the second isolation linear module is used for carrying out isolation and linear processing on the output voltage of the detector and generating an output voltage feedback isolation signal of the detector;
the first analog-to-digital conversion module is used for performing analog-to-digital conversion on the feedback isolation signal of the output voltage of the detector to generate an output voltage feedback digital signal of the detector;
the power supply and control module is also used for feeding back a digital signal according to the output voltage of the detector and adjusting the given control signal of the voltage of the detector.
In one embodiment, the isolation module further includes an isolation power supply module, and the voltage levitation control apparatus further includes a first switch module, wherein:
the first switch module is used for switching off or switching on the power supply and the working power supply provided by the control module to the detector;
the isolation power supply module is used for providing an isolation power supply for the detector after the working power supply is isolated.
In one embodiment, the acceleration region comprises an acceleration positive high voltage region and an acceleration negative high voltage region, and the voltage levitation control device further comprises a second switch module, wherein the second switch module is respectively connected with the power supply and control module, the acceleration positive high voltage region and the acceleration negative high voltage region, and is used for selecting one of the acceleration positive high voltage region and the acceleration negative high voltage region to be connected with the power supply and control module, so that the acceleration region output voltage output by the acceleration region is switched between a positive high voltage and a negative high voltage.
In one embodiment, the second switch module comprises a power switch, a polarity switch and a first relay, the power switch, the polarity switch and the first relay are connected between the power and control module and the acceleration region, wherein:
the power switch and the polarity change-over switch are used for cooperatively controlling the first relay to select one of the acceleration positive high-voltage area and the acceleration negative high-voltage area to be connected with the power supply and control module.
In one embodiment, the voltage levitation control device further includes a second digital-to-analog conversion module and a second analog-to-digital conversion module, where the second digital-to-analog conversion module is configured to perform digital-to-analog conversion on the acceleration region voltage given control signal to generate an acceleration region voltage given analog control signal;
the acceleration region generates an acceleration region output voltage according to the acceleration region voltage given analog control signal;
the second analog-to-digital conversion module is used for performing analog-to-digital conversion on the output voltage of the acceleration area to generate an output voltage feedback digital signal of the acceleration area;
the power supply and control module is also used for feeding back a digital signal according to the output voltage of the acceleration area and adjusting the given control signal of the voltage of the acceleration area.
In one embodiment, the voltage levitation control device further comprises a second relay and a third relay, wherein,
the input end of the second relay is respectively connected with the output end of the accelerating positive high-voltage region and the output end of the first relay, and the output end of the second relay is connected with the grounding end of the detector;
the input end of the third relay is respectively connected with the output end of the accelerating negative high-voltage area and the output end of the first relay, and the output end of the third relay is connected with the grounding end of the detector.
In one embodiment, the voltage suspension control device further comprises a first discharging circuit, wherein the first discharging circuit is connected with the output end of the acceleration region and is used for releasing charges accumulated in the acceleration positive high-voltage region or the acceleration negative high-voltage region before a circuit working at the current moment is switched between the acceleration positive high-voltage region and the acceleration negative high-voltage region, and the second switching module controls the acceleration positive high-voltage region and the acceleration negative high-voltage region to switch after the voltage of the acceleration positive high-voltage region or the acceleration negative high-voltage region drops to a first preset voltage.
In one embodiment, the voltage levitation control device further comprises a second discharging circuit, wherein the second discharging circuit is connected to the output end of the detector and is used for discharging the charges accumulated by the detector before the circuit working at the current moment is switched between the acceleration positive high-voltage area and the acceleration negative high-voltage area, and the second switching module controls the acceleration positive high-voltage area and the acceleration negative high-voltage area to switch after the voltage of the detector is reduced to a second preset voltage.
In one embodiment, the voltage levitation control device further comprises a first filter circuit, wherein the first filter circuit is connected with the output end of the acceleration positive high-voltage region and the output end of the acceleration negative high-voltage region and is used for filtering the output voltage of the acceleration positive high-voltage region or the acceleration negative high-voltage region.
In one embodiment, the voltage levitation control device further includes a second filter circuit, and the second filter circuit is connected to the output terminal of the detector and is configured to filter the output voltage of the detector.
A voltage levitation control method, comprising:
acquiring a detector voltage given control signal and an acceleration area voltage given control signal;
generating an accelerating area output voltage according to the accelerating area voltage given control signal;
isolating the detector voltage given control signal to generate a detector voltage given isolation control signal;
generating a detector first voltage according to the detector voltage given isolation control signal;
and performing suspension superposition on the first voltage of the detector and the output voltage of the acceleration area to obtain the output voltage of the detector.
A time-of-flight mass spectrometer comprising a voltage levitation control device as described above.
According to the voltage suspension control device, the control method and the time-of-flight mass spectrometer, the isolation module is used for isolating the given control signal of the detector voltage provided by the power supply and the control module, the detector generates the first voltage of the detector according to the isolated control signal, and the first voltage of the detector is connected with the output end of the acceleration area through the grounding end of the detector, so that the output voltage of the detector is the suspension superposed voltage of the first voltage of the detector and the output voltage of the acceleration area, and the independent flexible control and integration of the voltage of the acceleration area and the voltage of the detector are realized.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings of the embodiments can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of a voltage levitation control apparatus of a first embodiment;
FIG. 2 is a schematic diagram of a voltage levitation control apparatus of a second embodiment;
FIG. 3 is a schematic view of a voltage levitation control apparatus according to a third embodiment;
FIG. 4 is a schematic view of a voltage levitation control apparatus according to a fourth embodiment;
FIG. 5 is a schematic view of a voltage levitation control apparatus according to a fifth embodiment;
FIG. 6 is a schematic view of a voltage levitation control apparatus according to a sixth embodiment;
FIG. 7 is a schematic view of a voltage levitation control apparatus of a seventh embodiment;
FIG. 8 is a schematic view of a voltage levitation control apparatus according to an eighth embodiment;
FIG. 9 is a schematic view of a voltage levitation control apparatus of a ninth embodiment;
FIG. 10 is a schematic view of a voltage levitation control apparatus of a tenth embodiment;
fig. 11 is a flowchart illustrating a voltage suspension control method according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
As shown in fig. 1, a schematic diagram of a voltage levitation control device according to an embodiment of the present invention is provided, where the voltage levitation control device specifically includes: a power supply and control module 100, an acceleration zone 200, an isolation module 300, and a detector 400; wherein:
the power supply and control module 100 is used for providing a detector voltage setting control signal and an acceleration region voltage setting control signal, and providing power supply for the voltage levitation control device.
The acceleration region 200 is used to generate an acceleration region output voltage according to the acceleration region voltage given control signal.
The isolation module 300 is configured to isolate the detector voltage given control signal and generate a detector voltage given isolation control signal according to the detector voltage given control signal.
The detector 400 is configured to generate a first detector voltage according to the given isolation control signal of the detector voltage, and a ground terminal of the detector 400 is connected to an output terminal of the acceleration region 200, so that an output voltage of the detector 400 is a floating superposition voltage of the first detector voltage and an output voltage of the acceleration region 200.
The voltage suspension control device provided by the embodiment isolates the power supply and the detector voltage given control signal provided by the control module through the isolation module, the detector generates the first voltage of the detector according to the isolated control signal, and the first voltage of the detector is connected with the output end of the acceleration area through the grounding end of the detector, so that the output voltage of the detector is the suspension superposed voltage of the first voltage of the detector and the output voltage of the acceleration area, and the independent and flexible control and integration of the voltage of the acceleration area and the voltage of the detector are realized.
In one embodiment, when detecting the positive ion mode, the first voltage of the detector is superposed on the high voltage of the acceleration zone of 0 to-5000V in a suspension mode; when the negative ion mode is detected, the first voltage of 0 to +2000V of the detector is superposed on the high voltage of 0 to +5000V of the acceleration zone in a suspension manner.
In one embodiment, as shown in fig. 2, the isolation module 300 may specifically include a first isolation linear module 310 and a second isolation linear module 320, and the voltage levitation control apparatus further includes a first digital-to-analog conversion module 500 and a first analog-to-digital conversion module 600; wherein:
the first digital-to-analog conversion module 500 is configured to perform digital-to-analog conversion on the detector voltage given control signal to generate a detector voltage given analog control signal.
The first isolation linearity module 310 is configured to perform isolation and linear processing on the detector voltage setting control analog signal to generate a detector voltage setting isolation control signal, and the detector 400 generates a detector first voltage according to the detector voltage setting isolation control signal. In one embodiment, when the first dac module 500 outputs 0-10V, the first voltage of the detector 400 is 0 to + 2000V.
The second isolation linearity module 320 is used for performing isolation and linearity processing on the output voltage of the detector 400 to generate an output voltage feedback isolation signal of the detector 400.
The first analog-to-digital conversion module 600 is configured to perform analog-to-digital conversion on the feedback isolation signal of the output voltage of the detector to generate an output voltage feedback digital signal of the detector 400.
The power and control module 100 is further configured to adjust the detector voltage according to the output voltage feedback digital signal of the detector 400, and further adjust the output voltage of the detector 400.
In one embodiment, as shown in fig. 3, the isolation module further includes an isolation power supply module 330, and the voltage levitation control apparatus further includes a first switch module 700, where:
the first switching module 700 is used to turn off or on the power and control module 100 to provide the operating power to the detector 400.
The isolation power supply module 330 is configured to provide an isolation power supply for the detector 400 after performing isolation processing on the working power supply.
In one embodiment, as shown in fig. 4, the acceleration region 200 may specifically include an acceleration positive high voltage region 210 and an acceleration negative high voltage region 220, and the voltage levitation control apparatus further includes a second switch module 800, which is respectively connected to the power supply and control module 100, the acceleration positive high voltage region 210, and the acceleration negative high voltage region 210, and is configured to select one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to be connected to the power supply and control module 100, so that the acceleration region output voltage output by the acceleration region 200 is switched between a positive high voltage and a negative high voltage.
In one embodiment, as shown in fig. 5, the second switch module 800 includes a power switch 820, a polarity switch 840 and a first relay 860, and the power switch 820, the polarity switch 840 and the first relay 860 are connected between the power and control module 100 and the acceleration region 200, wherein: the power switch 820 and the polarity switch 840 are used to cooperate to control the first relay 860 to select one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to be connected to the power and control module 100.
In one embodiment, as shown in fig. 6, the voltage levitation control apparatus may further include a second digital-to-analog conversion module 900 and a second analog-to-digital conversion module 1000, where the second digital-to-analog conversion module 900 is configured to perform digital-to-analog conversion on the acceleration region voltage given control signal to generate an acceleration region voltage given analog control signal.
The acceleration region 200 generates an acceleration region output voltage based on the acceleration region voltage given analog control signal. In one embodiment, when the second DAC module 900 outputs 0-10V, the output voltage of the corresponding accelerating region 500 is 0-5000V.
The second analog-to-digital conversion module 1000 is configured to perform analog-to-digital conversion on the output voltage of the acceleration region to generate an output voltage feedback digital signal of the acceleration region.
The power supply and control module 100 is further configured to adjust the given control signal of the voltage of the acceleration region according to the output voltage feedback digital signal of the acceleration region, and further control the output voltage of the acceleration region.
In one embodiment, as shown in fig. 7, the voltage levitation control apparatus may further include a second relay 1100 and a third relay 1200, wherein,
the input terminal of the second relay 1100 is connected to the output terminal of the accelerating positive high voltage region 210 and the output terminal of the first relay 860, respectively, and the output terminal of the second relay 1100 is connected to the ground terminal of the detector 400. The second relay 1100 is a high voltage relay for selectively connecting one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to the power supply and control module 100 in cooperation with the first relay 860.
The input terminal of the third relay 1200 is connected to the output terminal of the accelerating negative high voltage region 220 and the output terminal of the first relay 860, respectively, and the output terminal of the third relay 1200 is connected to the ground terminal of the detector 400. The third relay 1200 is a high voltage relay, and is used for selecting one of the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to be connected with the power supply and control module 100 in cooperation with the first relay 860.
In one embodiment, as shown in fig. 8, the voltage levitation control apparatus further includes a first discharging circuit 1300, where the first discharging circuit 1300 is connected to an output terminal of the acceleration region 200, and is configured to release charges accumulated in the acceleration positive high-voltage region 210 or the acceleration negative high-voltage region 220 before a circuit operating at the present moment switches between the acceleration positive high-voltage region 210 and the acceleration negative high-voltage region 220, and the second switching module 800 controls the acceleration positive high-voltage region 210 and the acceleration negative high-voltage region 220 to switch after a voltage of the acceleration positive high-voltage region 210 or the acceleration negative high-voltage region 220 drops to a first preset voltage.
The voltage suspension control device provided by the embodiment quickly releases the electric charges accumulated in the acceleration positive high-voltage area or the acceleration negative high-voltage area before the acceleration positive high-voltage area and the acceleration negative high-voltage area are switched through the first discharge circuit, and after the voltage of the acceleration positive high-voltage area or the acceleration negative high-voltage area is reduced to the first preset voltage, the second switch module controls the acceleration positive high-voltage area and the acceleration negative high-voltage area to execute quick switching, so that quick switching detection of positive ions and negative ions is realized, the research and development period is greatly shortened, and the research and development cost is reduced.
In one embodiment, the first preset voltage may be 0V or a relatively low preset voltage, and the first discharge circuit may complete the switching between the acceleration positive high-voltage region and the acceleration negative high-voltage region within 1.5s, so as to implement the fast and stable polarity switching.
In one embodiment, as shown in fig. 8, the voltage levitation control apparatus further includes a second discharging circuit 1400, where the second discharging circuit 1400 is connected to the output terminal of the detector 400, and is used for releasing the charges accumulated in the detector 400 before the circuit operating at the present moment switches between the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220, and the second switching module 800 controls the acceleration positive high voltage region 210 and the acceleration negative high voltage region 220 to switch after the voltage of the detector drops to a second preset voltage (which may be 0V or a lower preset voltage).
The voltage suspension control device provided by the embodiment can realize the rapid and stable polarity switching between the accelerating positive high-voltage area and the accelerating negative high-voltage area through the second discharge circuit, thereby realizing the rapid switching detection of positive ions and negative ions.
In one embodiment, as shown in fig. 8, the voltage levitation control apparatus further includes a first filter circuit 1500, where the first filter circuit 1500 is connected to an output terminal of the acceleration positive high voltage region 210 and an output terminal of the acceleration negative high voltage region 220, and is configured to filter an output voltage of the acceleration positive high voltage region 210 or the acceleration negative high voltage region 220.
In one embodiment, as shown in fig. 8, the voltage levitation control apparatus further includes a second filter circuit 1600, and the second filter circuit 1600 is connected to the output terminal of the detector 400 for filtering the output voltage of the detector 400.
In one embodiment, as shown in fig. 9, the first discharging circuit 1300 may specifically include at least one first resistor R1 (the resistance of each first resistor may be different, and the specific resistance may be selected according to the actual usage scenario), and may specifically include five first resistors R1, where one end of each first resistor is connected to the output end 210 of the acceleration positive high-voltage region and the output end of the acceleration negative high-voltage region 220, and the other end is grounded.
In one embodiment, as shown in fig. 9, the second discharge circuit 1400 includes at least one third resistor R3 (the resistance of each third resistor may be different, and the specific resistance may be selected according to the actual usage scenario), and one end of each third resistor R3 is connected to the output terminal of the detector 400, and the other end is grounded.
In one embodiment, as shown in fig. 9, the first filter circuit 1500 may specifically include a fourth resistor R4, a fifth resistor R5, a first capacitor C1, a second capacitor C2, a third capacitor C3, and a first inductor L1, wherein the fourth resistor R4, the fifth resistor R5, and the first inductor L1 are sequentially connected in series between the output ends of the acceleration positive high-voltage region 210 and the acceleration negative high-voltage region 220 and the output end of the first filter circuit 1500; the first capacitor C1 is connected between the output terminals of the accelerating positive high-voltage region 210 and the accelerating negative high-voltage region 220 and the ground terminal; the second capacitor C2 is connected between the connection node of the fourth resistor R4 and the fifth resistor R5 and the ground terminal; the third capacitor C3 is connected between the ground and the connection node of the fifth resistor R5 and the first inductor L1.
In one embodiment, the output high voltage ripple of the accelerating positive high voltage region 210 and the accelerating negative high voltage region 220 can be controlled within 50mV by the RCL multi-stage low-pass first filter circuit 1500 composed of a plurality of resistors, capacitors and inductors, so that the requirement of high resolution of the time-of-flight mass spectrometer is well met.
In one embodiment, as shown in fig. 9, the second filter circuit 1600 includes a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a fourth capacitor C4, a fifth capacitor C5, a sixth capacitor C6, and a second inductor L2, wherein the sixth resistor R6, the seventh resistor R7, the eighth resistor R8, and the second inductor L2 are sequentially connected in series between the output terminal of the detector 400 and the output terminal of the second filter circuit 1600; the fourth capacitor C4 is connected between the connection node of the sixth resistor R6 and the seventh resistor R7 and the ground terminal; the fifth capacitor C5 is connected between the connection node of the seventh resistor R7 and the eighth resistor R8 and the ground terminal; the sixth capacitor C6 is connected between the ground and the connection node of the eighth resistor R8 and the second inductor L2.
In one embodiment, the RCL multistage low-pass second filter circuit 1600, which is composed of a plurality of resistors, capacitors and inductors, allows the output high-voltage ripple of the detector 400 to be controlled within 50mV, which well meets the requirement of high resolution of the time-of-flight mass spectrometer.
In one embodiment, as shown in fig. 10, the voltage levitation control apparatus may further include a detector pole piece 1700 and an acceleration region pole piece 1800, wherein the detector pole piece 1700 is connected to the output terminal of the detector 400, and the acceleration region pole piece 1800 is connected to the output terminal of the acceleration region 200; detector pole piece 1700 and acceleration region pole piece 1800 are placed in a vacuum chamber. The voltage of the pole piece 1800 in the acceleration region can be independently and flexibly adjusted and monitored through the acceleration region 200, and the voltage between the pole piece 1700 of the detector and the pole piece 1800 in the acceleration region can be independently and flexibly adjusted and monitored through the detector 1700, so that the high voltage is effectively applied to the detector 1700, and the independent and flexible adjustment of the ion acceleration kinetic energy and the independent and flexible adjustment of the gain of the detector are realized simultaneously.
In one embodiment, the detector may be a micro Channel plate mcp (micro Channel plate), which is an ion detector and is a plate-like electron multiplier composed of a plurality of parallel micro channels capable of generating secondary electrons. The performance parameters of the micro-channel plate MCP mainly comprise a micro-channel aperture d, a micro-channel inclination angle theta, a micro-channel plate thickness h, current gain and the like.
The invention also provides a voltage suspension control method, which is applicable to a time-of-flight mass spectrometer, and as shown in fig. 11, the voltage suspension control method specifically comprises the following steps:
step 100: a detector voltage given control signal and an acceleration region voltage given control signal are acquired.
Step 200: and generating an output voltage of the acceleration region according to the given control signal of the voltage of the acceleration region.
Step 300: isolating the detector voltage given control signal generates a detector voltage given isolation control signal.
Step 400: a detector first voltage is generated based on the detector voltage given isolation control signal.
Step 500: and performing suspension superposition on the first voltage of the detector and the output voltage of the acceleration area to obtain the output voltage of the detector.
The voltage suspension control method provided by the embodiment generates the first voltage of the detector by isolating the voltage given control signal of the detector and giving the isolation control signal according to the voltage of the detector, performs suspension superposition on the first voltage of the detector and the output voltage of the acceleration region to obtain the output voltage of the detector, and realizes independent and flexible control and integration of the voltage of the acceleration region and the voltage of the detector.
The voltage suspension control method in this embodiment is the same as the voltage suspension control device in the embodiment corresponding to fig. 1, and the specific implementation process is described in detail in the corresponding device embodiment, and the technical features in the device embodiment are all applicable in this method embodiment, which is not described herein again.
The invention also provides a time-of-flight mass spectrometer which specifically can comprise the voltage suspension control device.
In the present invention, the terms "first", "second", and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance; the term "plurality" means two or more unless expressly limited otherwise. The terms "mounted," "connected," "fixed," and the like are to be construed broadly, and for example, "connected" may be a fixed connection, a removable connection, or an integral connection; "coupled" may be direct or indirect through an intermediary. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the description herein, the description of the terms "one embodiment," "some embodiments," "specific embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (13)
1. A voltage levitation control apparatus, comprising: the device comprises a power supply and control module, an acceleration area, an isolation module and a detector; wherein:
the power supply and control module is used for providing a detector voltage given control signal and an acceleration area voltage given control signal and providing a power supply for the voltage suspension control device;
the acceleration region is used for generating an acceleration region output voltage according to the acceleration region voltage given control signal;
the isolation module is used for isolating the detector voltage given control signal and generating a detector voltage given isolation control signal according to the detector voltage given control signal;
the detector is used for giving an isolation control signal according to the voltage of the detector to generate a first voltage of the detector, the grounding end of the detector is connected with the output end of the acceleration area, and the output voltage of the detector is the suspension superposition voltage of the first voltage of the detector and the output voltage of the acceleration area.
2. The voltage levitation control device of claim 1, wherein the isolation module comprises a first isolation linear module and a second isolation linear module, the voltage levitation control device further comprising a first digital-to-analog conversion module and a first analog-to-digital conversion module; wherein:
the first digital-to-analog conversion module is used for performing digital-to-analog conversion on the detector voltage given control signal to generate a detector voltage given analog control signal;
the first isolation linear module is used for carrying out isolation and linear processing on the detector voltage given control analog signal to generate a detector voltage given isolation control signal, and the detector generates a detector first voltage according to the detector voltage given isolation control signal;
the second isolation linear module is used for carrying out isolation and linear processing on the output voltage of the detector and generating an output voltage feedback isolation signal of the detector;
the first analog-to-digital conversion module is used for performing analog-to-digital conversion on the feedback isolation signal of the output voltage of the detector to generate an output voltage feedback digital signal of the detector;
the power supply and control module is also used for feeding back a digital signal according to the output voltage of the detector and adjusting the given control signal of the voltage of the detector.
3. The voltage sag control device according to claim 2, wherein the isolation module further comprises an isolation power supply module, the voltage sag control device further comprising a first switch module, wherein:
the first switch module is used for switching off or switching on the power supply and the working power supply provided by the control module to the detector;
the isolation power supply module is used for providing an isolation power supply for the detector after the working power supply is isolated.
4. The voltage levitation control device as claimed in claim 3, wherein the acceleration region comprises an acceleration positive high voltage region and an acceleration negative high voltage region, and the voltage levitation control device further comprises a second switch module, which is respectively connected to the power supply and control module, the acceleration positive high voltage region and the acceleration negative high voltage region, for selecting one of the acceleration positive high voltage region and the acceleration negative high voltage region to be connected to the power supply and control module, so that the acceleration region output voltage outputted by the acceleration region is switched between a positive high voltage and a negative high voltage.
5. The voltage levitation control device of claim 4, wherein the second switch module comprises a power switch, a polarity switch, and a first relay connected between the power and control module and the acceleration zone, wherein:
the power switch and the polarity change-over switch are used for cooperatively controlling the first relay to select one of the acceleration positive high-voltage area and the acceleration negative high-voltage area to be connected with the power supply and control module.
6. The voltage levitation control device as recited in claim 5, further comprising a second digital-to-analog conversion module and a second analog-to-digital conversion module, wherein the second digital-to-analog conversion module is configured to perform digital-to-analog conversion on the acceleration region voltage given control signal to generate an acceleration region voltage given analog control signal;
the acceleration region generates an acceleration region output voltage according to the acceleration region voltage given analog control signal;
the second analog-to-digital conversion module is used for performing analog-to-digital conversion on the output voltage of the acceleration area to generate an output voltage feedback digital signal of the acceleration area;
the power supply and control module is also used for feeding back a digital signal according to the output voltage of the acceleration area and adjusting the given control signal of the voltage of the acceleration area.
7. The voltage sag control device according to claim 6, further comprising a second relay and a third relay, wherein,
the input end of the second relay is respectively connected with the output end of the accelerating positive high-voltage region and the output end of the first relay, and the output end of the second relay is connected with the grounding end of the detector;
the input end of the third relay is respectively connected with the output end of the accelerating negative high-voltage area and the output end of the first relay, and the output end of the third relay is connected with the grounding end of the detector.
8. The voltage levitation control apparatus as recited in claim 7, further comprising a first discharging circuit connected to an output terminal of the acceleration section and configured to discharge charges accumulated in the acceleration positive high voltage region or the acceleration negative high voltage region before a circuit operating at a current time switches between the acceleration positive high voltage region and the acceleration negative high voltage region, wherein the second switching module controls the acceleration positive high voltage region and the acceleration negative high voltage region to switch between after the voltage of the acceleration positive high voltage region or the acceleration negative high voltage region drops to a first preset voltage.
9. The voltage levitation control apparatus as recited in claim 8, further comprising a second discharging circuit connected to an output terminal of the detector, and configured to discharge the charge accumulated in the detector before the circuit operating at the present moment switches between the accelerating positive high voltage region and the accelerating negative high voltage region, and the second switching module controls the accelerating positive high voltage region and the accelerating negative high voltage region to perform switching after the voltage of the detector drops to a second preset voltage.
10. The voltage sag control device according to claim 9, further comprising a first filter circuit connected to an output of the acceleration positive high-voltage region and an output of the acceleration negative high-voltage region, for filtering an output voltage of the acceleration positive high-voltage region or the acceleration negative high-voltage region.
11. The voltage sag control device according to claim 10, further comprising a second filter circuit coupled to the output of the detector for filtering the output voltage of the detector.
12. A voltage levitation control method, comprising:
acquiring a detector voltage given control signal and an acceleration area voltage given control signal;
generating an accelerating area output voltage according to the accelerating area voltage given control signal;
isolating the detector voltage given control signal to generate a detector voltage given isolation control signal;
generating a detector first voltage according to the detector voltage given isolation control signal;
and performing suspension superposition on the first voltage of the detector and the output voltage of the acceleration area to obtain the output voltage of the detector.
13. A time-of-flight mass spectrometer comprising a voltage levitation control apparatus as claimed in any one of claims 1 to 11.
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