CN113122395A - Liquid cleaning composition and method of making same - Google Patents
Liquid cleaning composition and method of making same Download PDFInfo
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- CN113122395A CN113122395A CN202010051061.6A CN202010051061A CN113122395A CN 113122395 A CN113122395 A CN 113122395A CN 202010051061 A CN202010051061 A CN 202010051061A CN 113122395 A CN113122395 A CN 113122395A
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- China
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- cleaning composition
- liquid cleaning
- surfactant
- polyoxyethylene polyoxypropylene
- fatty alcohol
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- 238000004140 cleaning Methods 0.000 title claims abstract description 167
- 239000007788 liquid Substances 0.000 title claims abstract description 150
- 239000000203 mixture Substances 0.000 title claims abstract description 144
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 80
- 239000004094 surface-active agent Substances 0.000 claims abstract description 78
- 102000004190 Enzymes Human genes 0.000 claims abstract description 41
- 108090000790 Enzymes Proteins 0.000 claims abstract description 41
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims abstract description 40
- 150000002191 fatty alcohols Chemical class 0.000 claims abstract description 35
- 239000002738 chelating agent Substances 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical compound C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002904 solvent Substances 0.000 claims abstract description 18
- 239000003381 stabilizer Substances 0.000 claims abstract description 18
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 15
- 229920000570 polyether Polymers 0.000 claims abstract description 15
- 239000003139 biocide Substances 0.000 claims abstract description 7
- 230000003115 biocidal effect Effects 0.000 claims abstract description 6
- 229940088598 enzyme Drugs 0.000 claims description 39
- 230000000844 anti-bacterial effect Effects 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 239000003899 bactericide agent Substances 0.000 claims description 11
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 7
- 108091005804 Peptidases Proteins 0.000 claims description 6
- 239000004365 Protease Substances 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 108010065511 Amylases Proteins 0.000 claims description 5
- 102000013142 Amylases Human genes 0.000 claims description 5
- 235000019418 amylase Nutrition 0.000 claims description 5
- 102000004882 Lipase Human genes 0.000 claims description 4
- 108090001060 Lipase Proteins 0.000 claims description 4
- 239000004367 Lipase Substances 0.000 claims description 4
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 4
- 235000019421 lipase Nutrition 0.000 claims description 4
- BWDBEAQIHAEVLV-UHFFFAOYSA-N 6-methylheptan-1-ol Chemical group CC(C)CCCCCO BWDBEAQIHAEVLV-UHFFFAOYSA-N 0.000 claims description 3
- 108010084185 Cellulases Proteins 0.000 claims description 3
- 102000005575 Cellulases Human genes 0.000 claims description 3
- 102000035195 Peptidases Human genes 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 229940025131 amylases Drugs 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000006260 foam Substances 0.000 abstract description 41
- 239000000243 solution Substances 0.000 description 33
- 238000012360 testing method Methods 0.000 description 30
- 238000013112 stability test Methods 0.000 description 12
- 239000002689 soil Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 10
- 239000003599 detergent Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 229940048842 sodium xylenesulfonate Drugs 0.000 description 3
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical group [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 2
- 108010020132 microbial serine proteinases Proteins 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000012958 reprocessing Methods 0.000 description 2
- 101100345345 Arabidopsis thaliana MGD1 gene Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- POLBLONFVZXVPI-UHFFFAOYSA-N N-methyl-sec-pseudobrucine Natural products O=C1CC2C3C(CC4=O)OCC=C2CN(C)CCC11C3N4C2=C1C=C(OC)C(OC)=C2 POLBLONFVZXVPI-UHFFFAOYSA-N 0.000 description 1
- FLBVMURVUYAZMG-UHFFFAOYSA-N Novacin Natural products CN1CCC23C4C5C(CC(=O)N4c6cc(C)c(C)cc26)OCC=C(C1)C5CC3=O FLBVMURVUYAZMG-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920013807 TRITON DF-12 Polymers 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 108010075550 termamyl Proteins 0.000 description 1
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- OHOTVSOGTVKXEL-UHFFFAOYSA-K trisodium;2-[bis(carboxylatomethyl)amino]propanoate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C(C)N(CC([O-])=O)CC([O-])=O OHOTVSOGTVKXEL-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/825—Mixtures of compounds all of which are non-ionic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/3418—Toluene -, xylene -, cumene -, benzene - or naphthalene sulfonates or sulfates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/008—Polymeric surface-active agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
Abstract
A liquid cleaning composition comprising, in 100 wt.%, based on the total weight of the liquid cleaning composition: (1)0.4-10 wt.% of a surfactant, wherein the surfactant comprises at least an ethylene oxide propylene oxide block polyether surfactant, a fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant, and a fatty alcohol polyoxyethylene polyoxypropylene ether surfactant; (2)2-10 wt.% of an enzyme; (3)0.5-5 wt.% of a biocide; (4)43-97.1 wt.% water; (5)0-10 wt.% of a chelating agent; (6)0-12 wt.% of an enzyme stabilizer; and (7)0-10 wt.% of a solubilizing agent. The liquid cleaning composition according to the invention has good stability, low foam level and strong cleaning power for proteinaceous and bloody stains.
Description
Technical Field
The present invention relates to a liquid cleaning composition, and more particularly to a liquid cleaning composition having a low level of foaming, which is particularly suitable for use in the cleaning of medical instruments.
Background
Liquid detergents, such as multienzyme detergents, are widely used in the cleaning and reprocessing of medical devices, and excessive foaming of multienzyme detergents during the cleaning and reprocessing of medical devices may result in inefficient cleaning. Also, automatic cleaning machines are now increasingly used in cleaning medical instruments and related equipment. If the detergent in the automatic washing machine has too high a foam level during washing, the automatic washing machine cannot operate. Therefore, automatic washing machines have stringent requirements on the level of foam in detergent applications.
Automatic cleaning machines are used under different temperature conditions, typically at room temperature or at elevated temperatures (e.g., 40℃.), which requires that the liquid detergent used be capable of maintaining relatively low foam levels at a variety of temperatures.
It is therefore of great interest to provide a liquid cleansing composition which has a low level of foam, good stability and good cleaning power at a variety of temperature conditions.
Disclosure of Invention
In view of the above problems in the prior art, the present disclosure aims to provide a new liquid cleaning composition that should at least have good stability, low foam levels, and strong cleaning power against proteinaceous and bloody stains.
Certain aspects of the present invention provide a liquid cleaning composition comprising, in 100 wt.% based on the total weight of the composition: (1)0.4-10 wt.% of a surfactant, wherein the surfactant comprises at least an ethylene oxide propylene oxide block polyether surfactant, a fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant, and a fatty alcohol polyoxyethylene polyoxypropylene ether surfactant; (2)2-10 wt.% of an enzyme; (3)0.5-5 wt.% of a biocide; (4)43-97.1 wt.% water; (5)0-10 wt.% of a chelating agent; (6)0-12 wt.% of an enzyme stabilizer; and (7)0-10 wt.% of a solubilizing agent.
Certain aspects of the present invention provide a method of preparing a liquid cleaning composition comprising the steps of: mixing the ingredients of the liquid cleaning composition.
The liquid cleaning composition according to the invention has good stability, low foam level and strong cleaning power for protein and bloody dirt in the cleaning process of medical instruments, and is particularly suitable for being used in automatic cleaning machines of medical instruments.
Detailed Description
It is to be understood that other various embodiments can be devised and modified by those skilled in the art in light of the teachings herein without departing from the scope or spirit of the invention. The following detailed description is, therefore, not to be taken in a limiting sense.
Unless otherwise indicated, all numbers expressing feature sizes, quantities, and physical and chemical characteristics used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the foregoing specification and attached claims are approximations that can be suitably varied by those skilled in the art in seeking to obtain the desired properties utilizing the teachings disclosed herein. The use of numerical ranges by endpoints includes all numbers within that range and any range within that range, for example, 1 to 5 includes 1, 1.1, 1.3, 1.5, 2, 2.75, 3, 3.80, 4, and 5, and the like.
Liquid cleaning composition
Certain aspects of the present invention provide a liquid cleaning composition comprising, in 100 wt.%, based on the total weight of the liquid cleaning composition: (1)0.4-10 wt.% of a surfactant, wherein the surfactant comprises at least an ethylene oxide propylene oxide block polyether surfactant, a fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant, and a fatty alcohol polyoxyethylene polyoxypropylene ether surfactant; (2)2-10 wt.% of an enzyme; (3)0.5-5 wt.% of a biocide; (4)43-97.1 wt.% water; (5)0-10 wt.% of a chelating agent; (6)0-12 wt.% of an enzyme stabilizer; and (7)0-10 wt.% of a solubilizing agent.
Surface active agent
In the liquid cleaning composition according to the present invention, the surfactant may provide good stability, lower foam level and stronger detergency to proteinaceous and bloody stains in the liquid cleaning composition.
According to certain embodiments, the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant is an etherate of an alkyl alcohol and oxyethylpropoxy monophenyl ether.
According to certain embodiments, the alkyl group of the alkyl alcohol has from 8 to 10 carbon atoms.
According to certain embodiments, the etherate of an alkyl alcohol and oxyethylpropoxy monophenyl ether may be selected from TRITON DF-12 available from Dow chemical (China) investment, Inc.
According to certain embodiments, the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant is isooctanol polyoxyethylene polyoxypropylene ether.
According to certain embodiments, the isooctanol polyoxyethylene polyoxypropylene ether can be selected from ECOSURF EH-6 available from Dow chemical (China) investment, Inc.
According to some embodiments, the ethylene oxide propylene oxide block polyether surfactant may be selected from those available from Shanghai specialty Chemicals (Shanghai) Co., Ltd
Antifoam 1601。
According to certain embodiments, the surfactant is present in an amount of 1-3 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition.
The surfactant is present in an amount of 0.4 to 10 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition. When the content of the surfactant is less than 0.4 wt.%, the stability of the liquid cleaning composition is poor; at a level of surfactant greater than 10 wt.%, the foam level of the liquid cleansing composition is too high.
According to certain embodiments, in order to achieve a good balance of properties in terms of stability, foam level, and detergency towards proteinaceous and bloody soils in a liquid cleaning composition for better results, the ethylene oxide propylene oxide block polyether surfactant preferably comprises from 25 to 40 wt.%, more preferably from 35 to 40 wt.%, based on 100 wt.% total weight of the ethylene oxide propylene oxide block polyether surfactant, the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant and the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant; the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant accounts for 25-40 wt% preferably, and accounts for 35-40 wt% more preferably; and the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant preferably accounts for 20-50 wt%, and more preferably accounts for 20-30 wt%.
Enzyme
In the liquid cleaning composition according to the present invention, the enzyme may decompose protein, starch, fat and cellulose among contaminants attached to the medical instrument into products having smaller molecular weights, so that the contaminants are more easily removed. The addition of the enzyme allows the liquid detergent composition to have good cleaning power against proteinaceous and bloody stains.
According to some embodiments, the enzyme comprises at least one member of the following group: proteases, amylases, lipases and cellulases.
According to certain embodiments, the protease may be selected from Savinase Espers 900L available from Novoxin (China) Biotechnology, Inc.
According to some embodiments, the protease may be selected from Savinase ultra 16XL available from Novoxin (China) Biotechnology, Inc.
According to certain embodiments, the protease may be selected from Liquanase Espers 900L available from Novoxin (China) Biotechnology, Inc.
According to certain embodiments, the amylase may be selected from Termamyl 300L, available from Novoxin (China) Biotechnology, Inc.
According to certain embodiments, the amylase may be selected from the group consisting of Amplify 12L available from Novoxin (China) Biotechnology, Inc.
According to some embodiments, the lipase may be selected from Lipex events 900L available from novacin (china) biotechnology limited.
According to certain embodiments, the cellulase enzyme may be selected from Carezyme premium 4500L available from Novoxil (China) Biotechnology, Inc.
The enzyme is present in an amount of 2-10 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition. When the enzyme is present in an amount of 2 to 10 wt.%, the liquid detergent composition has a strong cleaning power against protein and blood stains.
Bactericide
In the liquid cleaning composition according to the present invention, the bactericide has a good bactericidal effect.
According to certain embodiments, the bactericide is an isothiazolinone or a derivative of an isothiazolinone.
According to certain embodiments, the biocide may be selected from Nipaguard CG, available from dow chemical (china) investment limited.
The content of the bactericide is 0.5-5 wt.% based on 100 wt.% of the total weight of the liquid cleaning composition. When the content of the bactericide is 0.5 to 5 wt.%, the liquid cleaning composition has a good bactericidal effect.
Water (W)
In the liquid cleaning composition according to the present invention, the water is a solvent in the liquid cleaning composition.
The water is present in an amount of 43 to 97.1 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition. When the content of the water is 43 to 97.1 wt.%, the components in the liquid cleansing composition can be sufficiently dissolved.
Chelating agents
In the liquid cleaning composition according to the present invention, the chelating agent may improve the cleaning power of the liquid cleaning composition against proteinaceous and bloody stains as well as against starchy stains.
According to certain embodiments, the liquid cleaning composition comprises 0-10 wt.% of a chelating agent.
According to certain embodiments, the liquid cleaning composition comprises 0.5-10 wt.% of a chelating agent.
According to certain embodiments, the chelating agent is present in an amount of 0.5-5 wt.%.
According to certain embodiments, the chelating agent may be selected from D50 available from aksunobel corporation.
According to some embodiments, the chelating agent may be EDTA available from national institutes of chemical, Inc.
According to certain embodiments, the chelating agent may be MGDA available from aksunobel corporation.
According to some embodiments, the chelating agent may be sodium citrate available from national pharmaceutical group chemicals, ltd.
According to certain embodiments, the chelating agent may be selected from GLDA available from aksunobel corporation.
The chelating agent is present in an amount of 0-10 wt.%, preferably 0.5-10 wt.%, more preferably 0.5-5 wt.%, based on the total weight of the liquid cleaning composition as 100 wt.%. When the chelating agent is present in an amount of 0.5 to 10 wt.%, the liquid cleaning composition has good detergency not only on proteinaceous and bloody soils, but also on starchy soils.
Enzyme stabilizer
In the liquid cleaning composition according to the present invention, an enzyme stabilizer may be further included, and the enzyme stabilizer may stabilize the activity of the enzyme, allowing the enzyme activity to have long-term stability.
According to certain embodiments, the enzyme stabilizer comprises at least one member of the following group: sodium borate, glycerol and calcium chloride.
The enzyme stabilizer is present in an amount of 0-12 wt.%, preferably 0.1-12 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition. When the enzyme stabilizer is present in an amount of 0.1-12 wt.%, the liquid cleaning composition has good enzyme stability.
Solubilizer
In the liquid cleaning composition according to the present invention, a solubilizing agent may also be included, which may further improve the long-term stability of the liquid cleaning composition.
According to certain embodiments, the solubilizer is sodium xylene sulfonate.
According to some embodiments, the sodium xylene sulfonate can be sodium xylene sulfonate available from national pharmaceutical group chemical agents, ltd.
The solubilizer is present in an amount of 0 to 10 wt.%, preferably 0.1 to 10 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition. When the content of the solubilizer is in the range of 0.1 to 10 wt.%, the liquid cleaning composition has good long-term stability, i.e., the liquid cleaning composition does not precipitate or delaminate for a long period of time, and the liquid cleaning composition can remain clear and transparent.
Process for preparing liquid cleaning compositions
Certain aspects of the present invention provide a method of preparing a liquid cleaning composition comprising the steps of: the ingredients of the liquid cleaning composition according to the present invention are mixed.
According to certain embodiments, the method of preparing a liquid cleaning composition comprises, in 100 wt.% based on the total weight of the liquid cleaning composition, the steps of: adding 0.4-10 wt.% of a surfactant, 0-12 wt.% of an enzyme stabilizer, 0-10 wt.% of a solubilizing agent to 43-97.1 wt.% of water to obtain a first solution; adding 0.5-5 wt.% of a bactericide and 2-10 wt.% of an enzyme to the first solution to obtain a second solution; adding 0-10 wt.% chelating agent to the second solution to make up water to 100 wt.% to obtain a liquid cleaning composition.
For a description of the ingredients of the liquid cleaning composition, see the "liquid cleaning composition" section of this specification.
The following detailed description is intended to illustrate the disclosure by way of example and not by way of limitation.
Embodiment 1 is a liquid cleaning composition comprising, in 100 wt.% based on the total weight of the liquid cleaning composition: (1)0.4-10 wt.% of a surfactant, wherein the surfactant comprises at least an ethylene oxide propylene oxide block polyether surfactant, a fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant and a fatty alcohol polyoxyethylene polyoxypropylene ether surfactant; (2)2-10 wt.% of an enzyme; (3)0.5-5 wt.% of a biocide; (4)43-97.1 wt.% water; (5)0-10 wt.% of a chelating agent; (6)0-12 wt.% of an enzyme stabilizer; and (7)0-10 wt.% of a solubilizing agent.
Embodiment 2 is the liquid cleaning composition according to embodiment 1, wherein the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant is an etherate of an alkyl alcohol and oxyethylpropoxy monophenyl ether.
Embodiment 3 is the liquid cleaning composition of embodiment 2, wherein the alkyl group of the alkyl alcohol has 8 to 10 carbon atoms.
Embodiment 4 is a liquid cleaning composition according to any one of embodiments 1 to 3, wherein the fatty alcohol-polyoxyethylene-polyoxypropylene ether-based surfactant is isooctanol-polyoxyethylene-polyoxypropylene ether.
Embodiment 5 is the liquid cleaning composition of embodiment 1, wherein the ethylene oxide propylene oxide block polyether surfactant comprises 25 to 40 wt%, the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant comprises 25 to 40 wt%, and the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant comprises 20 to 50 wt%, based on 100 wt.% of the total weight of the ethylene oxide propylene oxide block polyether surfactant, the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant, and the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant.
Embodiment 6 is a liquid cleaning composition according to any one of embodiments 1 to 5, wherein the surfactant is present in an amount of 1 to 3 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition.
Embodiment 7 is a liquid cleaning composition according to any one of embodiments 1 to 6, wherein the liquid cleaning composition comprises 0.5 to 10 wt.% of a chelating agent, based on 100 wt.% of the total weight of the liquid cleaning composition.
Embodiment 8 is a liquid cleaning composition according to embodiment 7, wherein the chelating agent is present in an amount of 0.5 to 5 wt.%.
Embodiment 9 is a liquid cleaning composition according to any one of embodiments 1 to 8, wherein the enzyme comprises at least one member of the following group: proteases, amylases, lipases and cellulases.
Embodiment 10 is a liquid cleaning composition according to any of embodiments 1-9, wherein the liquid cleaning composition comprises 0.1-12 wt.% enzyme stabilizer.
Embodiment 11 is a liquid cleaning composition according to any one of embodiments 1 to 10, wherein the liquid cleaning composition comprises 0.1 to 10 wt.% of a solubilizer.
Embodiment 12 is a method of making a liquid cleaning composition comprising the steps of: mixing the ingredients of the liquid cleaning composition of any one of embodiments 1 to 11.
Embodiment 13 is the method of embodiment 12, wherein the method comprises the steps of, based on 100 wt.% of the total weight of the liquid cleaning composition: adding 0.4-10 wt.% of a surfactant, 0-12 wt.% of an enzyme stabilizer, 0-10 wt.% of a solubilizing agent to 43-97.1 wt.% of water to obtain a first solution; adding 0.5-5 wt.% of a bactericide and 2-10 wt.% of an enzyme to the first solution to obtain a second solution; adding 0-10 wt.% chelating agent to the second solution to make up water to 100 wt.% to obtain a liquid cleaning composition.
Embodiment 14 is the method of embodiment 12, wherein the method comprises, based on 100 wt.% of the total weight of the liquid cleaning composition, the steps of: adding 0.4-10 wt.% of a surfactant, 0.1-12 wt.% of an enzyme stabilizer, 0.1-10 wt.% of a solubilizing agent to 43-97.1 wt.% of water to obtain a first solution; adding 0.5-5 wt.% of a bactericide and 2-10 wt.% of an enzyme to the first solution to obtain a second solution; adding 0.5-10 wt.% of a chelating agent to the second solution to make up water to 100 wt.% to obtain a liquid cleaning composition.
Examples
The following examples and comparative examples are provided to aid in the understanding of the present invention and should not be construed as limiting thereof. All parts and percentages are by weight unless otherwise indicated.
The raw materials used in the examples of the present invention and the comparative examples are shown in table 1 below.
TABLE 1 raw materials used in examples and comparative examples
Preparation of liquid cleaning compositions
Adding the components of the liquid cleaning composition into a glass or stainless steel container to be mixed according to the following steps under the conditions of normal temperature (10-25 ℃) and normal pressure (about 1 atmospheric pressure) and the total weight of the liquid cleaning composition is calculated by 100 wt.% according to the total weight of the liquid cleaning composition, so as to obtain the liquid cleaning composition: adding 0.4-10 wt.% of a surfactant, 0-12 wt.% of an enzyme stabilizer, 0-10 wt.% of a solubilizing agent to 43-97.1 wt.% of water to obtain a first solution; adding 0.5-5 wt.% of a bactericide and 2-10 wt.% of an enzyme to the first solution to obtain a second solution; adding 0-10 wt.% chelating agent to the second solution to make up water to 100 wt.% to obtain a liquid cleaning composition.
The present invention evaluates the stability performance of liquid cleaning compositions by "stability testing".
The present invention evaluates the foam level of a liquid cleansing composition at the time of use by the "foam level test".
The ability of liquid cleaning compositions to clean proteinaceous and bloody soils was evaluated by the "STF cleaning power test".
The ability of the liquid cleaning compositions to clean starchy soils was evaluated by the "GKE cleaning power test".
Stability test
The stability of the liquid cleaning compositions of the present invention was tested according to the method of stability test in disinfection specifications 1.4.1.5.
The 37 ℃ stability test method comprises the steps of placing a sample to be tested in a 37 ℃ oven for 3 months, and observing the result. If the liquid cleaning composition solution is clear and transparent without delamination and precipitation in appearance, the stability test result is qualified; the stability test results are not acceptable if the liquid cleaning composition solution appears to delaminate, precipitate, or become cloudy.
The 54 ℃ stability test method is to place the sample to be tested in an oven at 54 ℃ for 2 weeks and observe the result. If the liquid cleaning composition solution is clear and transparent without delamination and precipitation in appearance, the stability test result is qualified; the stability test results are not acceptable if the liquid cleaning composition solution appears to delaminate, precipitate, or become cloudy.
Foam level test
(1) Foam level test at Normal temperature
2.5g of a sample to be measured was diluted with water at normal temperature (25 ℃) to 500g, and the volume of the obtained solution was about 500 mL. The level of foam generated was evaluated by vigorous stirring for 30 seconds with a calibrated domestic juicer (e.g., philips HR1724) and measuring the volume of solution 10 seconds after the stirring was stopped (see table 2a, table 2b and table 2c for specific data). If the liquid cleaning composition of the present invention is used in an automatic cleaning machine, compositions having a solution volume of not greater than 550mL (i.e., a foam level of not greater than 550mL) are preferred.
When the volume height of the solution is less than or equal to 550mL (namely the total height of the foam and the liquid is less than or equal to 550mL), the foam level is excellent; when 550mL < volume height of solution is less than or equal to 575mL (namely 550mL < total height of foam and liquid is less than or equal to 575mL), the foam level is good; when 575mL < solution volume height < 600mL (i.e. 575mL < total height of foam and liquid < 600mL), the foam level is medium; when the solution volume height is greater than or equal to 600mL (i.e., the total height of foam to liquid is greater than or equal to 600mL), the foam level is unacceptable.
(2) Foam level test at 40 deg.C
2.5g of a sample to be tested is diluted to 500g with water at 40 ℃, and the volume of the obtained solution is about 500 mL. The level of foam generated was evaluated by vigorous stirring for 30 seconds with a calibrated domestic juicer (e.g., philips HR1724) and measuring the volume of solution 10 seconds after the stirring was stopped (see table 2a, table 2b and table 2c for specific data). If the liquid cleaning composition of the present invention is used in an automatic cleaning machine, compositions having a solution volume of less than 510mL (i.e., a foam level of less than 510mL) are preferred.
When the volume height of the solution is less than 510mL (namely the total height of the foam and the liquid is less than 510mL), the foam level is excellent; when the volume height of the solution is more than or equal to 510mL and less than or equal to 520mL (namely the total height of the foam and the liquid is more than or equal to 510mL and less than or equal to 520mL), the foam level is good; when the solution volume height was > 520mL (i.e., the total height of foam to liquid was > 520mL), the foam level was off-specification.
STF cleaning force test
The liquid cleaning composition to be tested was diluted 1: 200 water to form a liquid cleaning composition dilution. The STF wash test cards were placed in 100 ml of a 40 ℃ dilution of the liquid cleaning composition. The time at which the red stain on the STF wash test card was completely removed was observed and recorded as the STF wash time.
When the STF cleaning time is less than 15 minutes, the cleaning force test result is excellent; when the STF cleaning time is less than or equal to 15 minutes and less than 20 minutes, the cleaning force test result is good; and when the STF cleaning time is more than or equal to 20 minutes, the cleaning force test result is unqualified.
GKE cleaning Power test
The liquid cleaning composition to be tested was diluted 1: 200 water to form a liquid cleaning composition dilution. The GKE leve13 blue soil test card was rinsed in 100 ml of a 40 ℃ dilution of a liquid cleaning composition for 15 minutes. The state of the test card soil remaining after 15 minutes was observed to evaluate the cleaning effect.
When the blue dirt on the GKE test card is completely removed or a little amount of residual dirt is left, the GKE test card is evaluated to be excellent; when a small amount of blue dirt remains on the GKE test card, the test card is evaluated to be good; when a large amount of blue dirt remains on the GKE test card, the GKE test card is evaluated to be medium; the test card was rated as failing when the blue soil on the GKE test card remained substantially intact.
Examples 1 to 11 and comparative examples 1 to 7
Liquid cleaning compositions were prepared as described above with reference to the ingredients and amounts thereof listed in tables 2a, 2b and 2c, respectively.
The "stability test", "foam level test", "STF cleaning force test" and "GKE cleaning force test" were carried out according to the methods described above, and the test results are also shown in table 2a, table 2b and table 2c, respectively.
TABLE 2a
TABLE 2b
TABLE 2c
According to tables 2a, 2b and 2 c:
examples 1-11 provide liquid cleaning compositions comprising at least suitable amounts of ethylene oxide propylene oxide block polyether surfactants, fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactants, fatty alcohol polyoxyethylene polyoxypropylene ether surfactants, enzymes, biocides and water, which provide liquid cleaning compositions having good stability, low foam levels and high cleaning power for proteinaceous and blood based soils. Examples 5-11 provide liquid cleaning compositions that further comprise an amount of chelating agent such that the liquid cleaning compositions have good cleaning power not only for proteinaceous and bloody soils, but also for starchy soils.
Comparative example 1 provides a liquid cleaning composition having a total surfactant content of less than 0.4 wt.%, and therefore, the liquid cleaning composition failed the stability test.
Comparative example 2 provides a liquid cleaning composition that uses other types of surfactants without the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether type surfactant and therefore has too high a foam level and fails the foam level test.
Comparative example 3 provides a liquid cleaning composition that uses other classes of surfactants without the ethylene oxide propylene oxide block polyether type surfactant and therefore has too high a foam level and fails the foam level test.
Comparative example 4 provides a liquid cleaning composition that does not contain a fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether type surfactant, and therefore, the liquid cleaning composition fails the foam level test at normal temperature.
Comparative example 5 provides a liquid cleaning composition that does not contain a fatty alcohol polyoxyethylene polyoxypropylene ether surfactant and therefore, the liquid cleaning composition fails the stability test at 54 ℃.
Comparative examples 6 and 7 provide liquid cleaning compositions that use other classes of surfactants without the use of fatty alcohol polyoxyethylene polyoxypropylene ether surfactants and therefore, the liquid cleaning compositions fail the stability test at 54 ℃.
In summary, the liquid cleaning composition according to the present invention comprises a proper amount of ethylene oxide propylene oxide block polyether surfactant, fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant, fatty alcohol polyoxyethylene polyoxypropylene ether surfactant, enzyme, bactericide and water, so that the liquid cleaning composition has good stability, low foam level and strong detergency to protein and blood dirt.
Although the foregoing detailed description contains many specific details for the purpose of illustration, it will be appreciated by those of ordinary skill in the art that numerous variations, alterations, substitutions and alterations to these details are within the scope of the invention as claimed. Therefore, the disclosure described in the detailed description does not impose any limitation on the invention as claimed. The proper scope of the invention should be determined by the appended claims and their proper legal equivalents. All cited references are incorporated herein by reference in their entirety.
Claims (13)
1. A liquid cleaning composition comprising, in 100 wt.%, based on the total weight of the liquid cleaning composition:
(1)0.4 to 10 wt.% of a surfactant,
wherein the surfactant at least comprises ethylene oxide propylene oxide block polyether surfactant, fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant and fatty alcohol polyoxyethylene polyoxypropylene ether surfactant;
(2)2-10 wt.% of an enzyme;
(3)0.5-5 wt.% of a biocide;
(4)43-97.1 wt.% water;
(5)0-10 wt.% of a chelating agent;
(6)0-12 wt.% of an enzyme stabilizer; and
(7)0-10 wt.% of a solubilizer.
2. The liquid cleaning composition according to claim 1, wherein the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant is an etherate of an alkyl alcohol and oxyethylpropoxy monophenyl ether.
3. The liquid cleaning composition of claim 2, wherein the alkyl group of the alkyl alcohol has 8 to 10 carbon atoms.
4. The liquid cleaning composition according to claim 1, wherein the fatty alcohol polyoxyethylene polyoxypropylene ether-based surfactant is isooctanol polyoxyethylene polyoxypropylene ether.
5. The liquid cleaning composition according to claim 1, wherein the ethylene oxide propylene oxide block polyether surfactant comprises 25 to 40 wt.%, the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant comprises 25 to 40 wt.%, and the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant comprises 20 to 50 wt.%, based on 100 wt.% of the total weight of the ethylene oxide propylene oxide block polyether surfactant, the fatty alcohol polyoxyethylene polyoxypropylene ether monobenzyl ether surfactant, and the fatty alcohol polyoxyethylene polyoxypropylene ether surfactant.
6. The liquid cleaning composition according to claim 1, wherein the surfactant is present in an amount of 1-3 wt.%, based on 100 wt.% of the total weight of the liquid cleaning composition.
7. The liquid cleaning composition according to claim 1, wherein the liquid cleaning composition comprises 0.5-10 wt.% of a chelating agent, based on the total weight of the liquid cleaning composition as 100 wt.%.
8. A liquid cleaning composition according to claim 7, wherein the chelating agent is present in an amount of 0.5-5 wt.%.
9. The liquid cleaning composition of claim 1, wherein the enzyme comprises at least one member of the group consisting of: proteases, amylases, lipases and cellulases.
10. The liquid cleaning composition of claim 1, wherein the liquid cleaning composition comprises 0.1-12 wt.% enzyme stabilizer.
11. The liquid cleaning composition according to claim 1, wherein the liquid cleaning composition comprises 0.1-10 wt.% of a solubilizing agent.
12. A method of making a liquid cleaning composition comprising the steps of: mixing the ingredients of the liquid cleaning composition according to any one of claims 1-11.
13. The method of claim 12, wherein the total weight of the liquid cleaning composition in 100 wt.% comprises the steps of:
adding 0.4-10 wt.% of a surfactant, 0-12 wt.% of an enzyme stabilizer, 0-10 wt.% of a solubilizing agent to 43-97.1 wt.% of water to obtain a first solution;
adding 0.5-5 wt.% of a bactericide and 2-10 wt.% of an enzyme to the first solution to obtain a second solution;
adding 0-10 wt.% chelating agent to the second solution to make up water to 100 wt.% to obtain a liquid cleaning composition.
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