CN105368588A - Liquid cleaning composition with biofilm removing function - Google Patents
Liquid cleaning composition with biofilm removing function Download PDFInfo
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- CN105368588A CN105368588A CN201510864027.XA CN201510864027A CN105368588A CN 105368588 A CN105368588 A CN 105368588A CN 201510864027 A CN201510864027 A CN 201510864027A CN 105368588 A CN105368588 A CN 105368588A
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- liquid cleansing
- weight
- cleansing composition
- isothiazolinone
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/83—Mixtures of non-ionic with anionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
Abstract
The invention provides a liquid cleaning composition with a biofilm removing function. The liquid cleaning composition comprises at least one surfactant, at least one hydrolytic enzyme, at least one compound and water, wherein the surfactant is selected from nonionic surfactants and anionic surfactants, and the compound is selected from isothiazolinone or derivative thereof.
Description
The application is international filing date is on May 7th, 2010, and international application no is PCT/US2010/034044, and national applications number is 201080030568.8, and denomination of invention is the divisional application of the application of " liquid cleansing composition with microbial film removing function ".
the cross reference of related application
This application claims the right of priority of the Chinese patent application No.200910137121.X submitted on May 7th, 2009, this patent is incorporated herein by reference.
Technical field
The present invention relates to the liquid cleansing composition with microbial film removing function, specifically, relate to the liquid cleansing composition in the automatic cleaning of medical apparatus with microbial film removing function.
Background technology
In the cleaning of medical apparatus, usually can run into the such as stain such as human secretion, bloodstain.In addition, under some specific environment, the equipment such as spent the night or with the instruments of blood or the tube chamber of endoscope, microorganism is very easy to be existed in biomembranous mode.Microbial film has the macrostructure of several millimeters to several centimetres, can cover very large region.In fact, at medical treatment and industrial circle, microbial film is very serious problem.Such as, the infection that the equipment of infection, graft etc. that the formation of plaque, endoscope lens and conduit cause causes, all these usually can form microbial film.The general method of cleaning and sterilization cannot remove microbial film usually effectively, and this adversely can affect the subsequent disposal of utensil.
More generally, in automatic rinser, carry out the cleaning of medicine equipment and relevant device.For the sanitising agent for automatic rinser, have higher requirement.
Therefore, need to provide a kind of liquid cleansing composition, it can remove microbial film effectively, and is applicable to automatic rinser.
Summary of the invention
An object of the present invention is to provide a kind of liquid cleansing composition, it can remove microbial film effectively, includes but not limited to for automatic rinser.
Unexpectedly, contriver finds that the liquid cleansing composition comprising tensio-active agent, lytic enzyme and isothiazolinone and derivative thereof effectively can remove the microbial film on medical apparatus.Especially surprisingly, liquid cleansing composition of the present invention can especially effectively for the automatic rinser of medical apparatus.
Therefore, the invention provides the liquid cleansing composition comprising following composition:
At least one is selected from the tensio-active agent of nonionogenic tenside and anion surfactant;
At least one lytic enzyme;
At least one is selected from the compound of isothiazolinone and derivative thereof; And
Water.
Liquid cleansing composition of the present invention is particularly useful for cleaning medical apparatus (as medicine equipment and equipment), such as instruments, endoscope, catheter etc.Composition as herein described is also applicable to family or business Cleaning application, such as air-conditioning, condensate pipe etc.Liquid cleansing composition of the present invention is had the microbial film being difficult to be removed by ordinary method and significantly removes effect.Liquid cleansing composition of the present invention also has outstanding removing effect to the such as stain such as protein, starch.According to the demand, liquid cleansing composition of the present invention can be mixed with the low foam composition that is applicable to automatic rinser or be mixed with the transparent composition being applicable to manual cleaning.
Embodiment
In the present invention, except as otherwise noted, otherwise term " microbial film " refers to and is stiffly attached on the surface and the microorganism cells set be difficult to by simply rinsing removing, wherein microorganism is mainly with the form of extracellular polysaccharide class material or wrap quilt by extracellular polysaccharide class material.After in bacterial adhesion to material surface, aqueous polymers structure is by spontaneous generation and concentrate together, thus is formed and be called biomembranous structure.The formation of these attached cells group and can chronic bacterial infection be caused to the patience of antimicrobial substance.The free bacterium of bacterium in microbial film from corresponding in physiology is different.Bacterium in microbial film exists with cooperative mode, closely similar with many cells life form.
Except as otherwise noted, otherwise term " isothiazolinone derivatives " refer to using isothiazolinone as basic structure and the compound adding functional group's (as halogen, sulphur, hydroxyl, carboxyl, phenyl etc.) by replacement known in the art or addition method or add side chain (such as methyl, ethyl etc.) and make.
Except as otherwise noted, otherwise term " fatty alcohol " has ROH general formula.R is generally C
8-C
18, and be preferably C
12-C
18hydroxyl.Such high fatty alcohol has amphipathic, and that is, molecule not only has hydrophobic grouping (such as carbon-hydrogen chain), also has hydrophilic radical (such as hydroxyl).
For a person skilled in the art, term " oxirane " is known.Example comprises oxyethane.Ethylene glycol has HOC
2h
2oH structure, wherein directly can there is condensation reaction in hydroxyl.If this reaction occurs between two ethylene glycol, then form ethylene glycol polymer; If this reaction occurs between the hydroxyl of same glycol molecule two ends, then form ring shaped molecule structure, i.e. oxyethane.This structure be not chemically very stable, often open loop and other substance reactions.
Except as otherwise noted, otherwise term " lytic enzyme " refers to the enzyme being acted on substrate (reaction object) by hydrolysis reaction.
Except as otherwise noted, otherwise term " carbohydrase " refers to the enzyme of hydrolyzable glucide.Glucide herein not only comprises the carbohydrate using glucose unit as elementary cell, also comprises polyhydroxy substance part.
Except as otherwise noted, otherwise term " amylase " refers to the enzyme of hydrolyzable starch.Such as, Stainzyme, Termamyl300L, BAN480L and Duramyl of NovozymesCo..
Except as otherwise noted, otherwise term " lipase " refers to the enzyme of hydrolyzable lipoid material.Such as, the Purafect of Lipolase and GenencorCo. of NovozymesCo..
Except as otherwise noted, otherwise term " proteolytic enzyme " refers to the enzyme of hydrolyzable protein matter.Alcalase, Esperase, Everlase, Savinase16XL, Liquanase and Polarzyme of such as NovozymesCo.; And the Properase of GenencorCo..
Can be used for " cellulase " commercially available acquisition of composition as herein described, Carezyme4500 and Endolase of such as NovozymesCo..
Except as otherwise noted, otherwise term " nonionogenic tenside " refers to the tensio-active agent not producing ion in aqueous.
Except as otherwise noted, otherwise term " Kathon " is the mixture of 5-chloro-2-methyl-4-isothiazolinone and MI, such as, from the KathonCG that RohmHaasCo. buys.
Especially, the invention provides the liquid cleansing composition comprising following composition:
At least one is selected from the tensio-active agent of nonionogenic tenside and anion surfactant;
At least one lytic enzyme;
At least one is selected from the compound of isothiazolinone and derivative thereof; And
Water.
In some preferred embodiments, nonionogenic tenside is selected from fatty alcohol alkylene oxide copolymers, polyhydroxy-alcohol and alkylol amide.
In a preferred embodiment, nonionogenic tenside is fatty alcohol alkylene oxide copolymers.More preferably, nonionogenic tenside is selected from and comprises the polymkeric substance that at least one is selected from the functional group of oxyethane, propylene oxide and butylene oxide ring.More preferably, the cloud point of nonionogenic tenside is in the scope of 10 DEG C to 60 DEG C.
In a preferred embodiment, fatty alcohol alkylene oxide copolymers accounts for the 1-20 % by weight of composition.
According to some embodiments, described at least one tensio-active agent is anion surfactant.The kind of anion surfactant is not limited.Such as, in some preferred embodiments, sulfated alkyl ether can be used as anion surfactant.In some other preferred embodiments, secondary alkyl sulfonate or alkylether sulfonate are used as anion surfactant.
In a preferred embodiment, by the total weight of composition, nonionogenic tenside or anion surfactant account at least 1 % by weight.In a preferred embodiment, by the total weight of composition, nonionogenic tenside or anion surfactant are no more than 20 % by weight.
In a preferred embodiment, described at least one lytic enzyme is selected from carbohydrase, proteolytic enzyme and lipase.More preferably, carbohydrase is selected from amylase, cellulase and mannosidase.In a more preferred embodiment, composition comprises at least two kinds of lytic enzymes.Even more preferably, described at least two kinds of lytic enzymes comprise carbohydrase and proteolytic enzyme.Also more preferably, described at least two kinds of lytic enzymes comprise lipase.
In a preferred embodiment, by the total weight of composition, lytic enzyme accounts at least 1 % by weight.In a preferred embodiment, by the total weight of composition, lytic enzyme is no more than 10 % by weight.
In a preferred embodiment, the Antimicrobe compound being selected from isothiazolinone and derivative thereof is added.More preferably, isothiazolinone and derivative thereof comprise 5-chloro-2-methyl-4-isothiazole and MI.
In a preferred embodiment, by the total weight of composition, isothiazolinone and derivative thereof account at least 0.0075 % by weight.In a preferred embodiment, by the total weight of composition, isothiazolinone and derivative thereof are no more than 1 % by weight.
In a preferred embodiment, liquid cleansing composition also comprises at least one solubilizing agent.Preferably, solubilizing agent is selected from sodium xylene sulfonate or its acid, xylene sulphonic acid sodium or its acid or alkyl amine oxide or their combination.In a preferred embodiment, solubilizing agent accounts for the 1-40 % by weight of composition.
According to some embodiments, liquid cleansing composition of the present invention comprises:
A) solubilizing agent: (such as sodium xylene sulfonate 40 or alkyl amine oxide) 12%-40%;
B) nonionogenic tenside: (such as, fatty alcohol-alkylene oxide copolymers) 0%-20%;
C) anion surfactant: (such as, sulfated alkyl ether) 0%-20%;
D) enzymic activity stablizer: (such as, borax) 1%-10%;
E) biocide: (such as, 5-chloro-2-methyl-4-isothiazole and MI) 0.0075%-0.045%;
F) enzyme 1:(is such as, amylase) 1-10%;
G) enzyme 2:(is such as, proteolytic enzyme) 0-10%;
H) enzyme 3:(is such as, Mierocrystalline cellulose) 0-5%;
I) enzyme 4:(is such as, Lipolase) 0-5% and
J) there is water, and usually add totally 100% to by the total weight of composition, prerequisite is that the total amount of nonionogenic tenside and anion surfactant is no more than 20%.
Liquid cleansing composition of the present invention can use after dilution 10 to 2,000 times.It is preferred for diluting 400 times.Composition also can sell client as product after directly diluting.
microbial film
Although be reluctant to be subject to the restriction of any theory, but contriver believes, it may be synergy based on kind of the component of three in the present composition (i.e. tensio-active agent, lytic enzyme and isothiazolinone or derivatives thereof) that liquid cleansing composition of the present invention can remove biomembranous reason in like this efficiently mode.Contriver believes, in liquid cleansing composition of the present invention, depends on this synergy, tensio-active agent can remove biomembranous outside stain, isothiazolinone or derivatives thereof can kill activated bacterial, and enzyme then can the extracellular polysaccharide structure of disrupting biofilm, as shown in Figure 1.
In the microbial film of reality, a large amount of dissimilar microorganisms can be comprised or using the microorganism of some type as the microorganism of major microorganisms.In experimental evaluation of the present invention, adopt Pseudomonas aeruginosa (pseudomonasaeruginosa) typically.Cultural method then according to ASTME-2562-07 (
http:// astm.nufu.eu), wherein cultivate under continuous shear stress condition in CDC biofilm reactor (CBR90-1DH-Int type (BioSurfaceTechnologiesCorp.)).
Infiltration is the Main Patterns of microbial film cleaning operation, and its program is similar with actual manual cleaning.The cleaning (such as) of automatic rinser produces mechanical effect by the flowing of water, and can strengthen biomembranous removing to a certain extent.
enzyme
Enzyme has multiple sorting technique.The enzyme of sanitising agent is generally lytic enzyme, that is, enzyme realizes cleaning performance by hydrolysis spot.Lytic enzyme has effective removing effect to the extracellular polysaccharide forming biofilm structure, therefore can promote biomembranous removing.
The example of lytic enzyme includes but not limited to carbohydrase, proteolytic enzyme, lipase and oxydo-reductase etc.Carbohydrase and proteolytic enzyme are preferred, and amylase and mannosidase are especially preferred.
The commercially available acquisition of carbohydrase used in the present invention.Carbohydrase can comprise amylase, Mierocrystalline cellulose and other sensu lato poly-hydroxy carbohydrate Substance P hydrolysis enzymes.
Starch based spot is hydrolyzed into the sugar with low relative molecular amount by amylase used in the present invention.Suitable amylase includes but not limited to Stainzyme, Termamyl300L, BAN480L, Duramyl of NovozymesCo..
Lipid spot is hydrolyzed into monoglyceride, triglyceride, lipid acid and glycerine by lipase used in the present invention.Suitable lipase includes but not limited to the Purafect of Lipolase, GenencorCo. of NovozymesCo..
Protein stain can be hydrolyzed into peptide and amino acid effectively to remove bloodstain by proteolytic enzyme used in the present invention.Suitable proteolytic enzyme includes but not limited to Alcalase, Esperase, Everlase, Savinase16XL, Liquanase, Polarzyme of NovozymesCo.; GenencorCo. Properase.
In a preferred embodiment, liquid cleansing composition of the present invention comprises for medical facilities cleaning with the proteolytic enzyme strengthening effect.The commercially available acquisition of Mierocrystalline cellulose used in the present invention, Carezyme4500, Endolase of such as NovozymesCo..
Enzyme is very responsive to general biocide, is usually easy to form precipitation or irreversible sex change occurs immediately.Contriver finds, the stabilized mixture that lytic enzyme, tensio-active agent and isothiazolinone can be used as liquid cleansing composition of the present invention coexists, and can not produce precipitation or irreversible sex change occurs.
nonionogenic tenside
Term " nonionogenic tenside " refers to the tensio-active agent not producing ion (or its amount can be ignored) in aqueous.Preferably, at least one nonionogenic tenside is selected from fatty alcohol alkylene oxide copolymers, polyhydroxy-alcohol and alkylol amide.
When using alkylene oxide surfactants, the carbonatoms of oxirane is preferably 2-5, preferred 2-4.
Term " polyhydroxy-alcohol " refers to C
nh
2n+2-x(OH)
x(x>=3), n>=3, preferably 3≤n≤100.
In the present invention, term " alkylol amide " refers to RCONH (C
nh
2no) H or RCON (C
nh
2no)
2, wherein R represents C
8 ~ 18alkyl (propping up) chain, preferred C
10 ~ 14alkyl (propping up) chain; 2≤n≤4.
In one embodiment, the derivative (such as fatty alcohol-polyoxyethylene ether) of fatty alcohol used in the present invention is for having the nonionogenic tenside of general formula A (EO) n, and wherein A represents alkyl, is generally C
8-C
18, preferred C
12-C
18alkyl, EO represents divinyl ether group (C
2h
4o), n represents the polymerization degree of EO, and 3≤n≤100.Another kind of fatty alcohol polyoxyalkylene ether has such as RO (C
2h
4o)
a(C
3h
6o)
b(C
4h
8o)
cstructural formula; Wherein R represents C
8-C
18alkyl (propping up) chain, a, b, c in the scope of 0-100, make a+b+c>=3 respectively.
Especially, nonionogenic tenside of the present invention includes but not limited to GenapolEP0244, GenapolED3060, GenapolBE2410 and GenapolUD/X/T series of ClariantChemcials; DF104 and DF123 of DowChemical; And the Monamid716 of CrodaCo..
A preferred property of nonionogenic tenside has the cloud point determined by its constitutional features.When the temperature of the aqueous solution of nonionogenic tenside raises, the wetting ability of solution weakens because of the destruction of hydrogen bond, and therefore, solution becomes white opacity solution from initial clear solution, such as milk sap.But this change is reversible, and when the temperature decreases, solution becomes vitreous state again.By add ethylene glycol, propylene glycol and butyleneglycol one or more and form polyether nonionic surfactant, the polyether nonionic surfactant of such as cloud point within the scope of 10-60 DEG C, low temperature and low foam characteristic can be obtained, also can obtain the cleansing power of relative good simultaneously.The nonionogenic tenside of other types can be used as additive to strengthen the stability of system.
anion surfactant
Anion surfactant because of its structure without cloud point.The liquid cleansing composition of the present invention comprising anion surfactant can keep transparent in the temperature range (such as 25 to 50 DEG C) that apparatus manual cleaning is used.
According to some embodiments, described at least one tensio-active agent is anion surfactant.Any anion surfactant can be used.Such as, in some preferred embodiments, sulfated alkyl ether can be used as anion surfactant.In some other preferred embodiments, secondary alkyl sulfonate or alkylether sulfonate are used as anion surfactant.
isothiazolinone and derivative thereof
The bacterial antibiotic grown in microbial film and the patience of sanitas are far above corresponding free bacterium, and the increase along with the biofilm formation time strengthens by its patience.Contriver finds, in the combination of components of liquid cleansing composition of the present invention, isothiazolinone and derivative thereof can effectively kill the bacterium grown in microbial film.Although have no intention bound by theory, it is believed that isothiazolinone and derivative thereof realize germicidal action by the combination destroyed between bacterium and algae protein.When contacting with microorganism, isothiazolinone or derivatives thereof can suppress rapidly and irreversibly suppress microbial growth in most cases, thus causes these microorganism cellss dead.Therefore, isothiazolinone and derivative thereof have very strong antibacterial and germicidal action to bacterium, fungi, algae etc.
Structural formula and the preferred isothiazolinone derivatives of isothiazolinone are as follows.
bubble
Automatic rinser has relatively high requirement to foaming level usually.Machine disturbs by too high foam volume, thus gives the alarm.If liquid cleansing composition of the present invention is used for automatic rinser, then preferably foaming level is no more than the composition of 750mL, as recorded by the laboratory foaming level measurement method in example.
The present invention will describe in more detail in conjunction with following instance.But, it should be pointed out that and the invention is not restricted to these examples.In example hereafter and comparative example, except as otherwise noted, otherwise all numbers, ratio and percentages being by weight, temperature is by a degree Celsius expression.
testing method
microbial film is cultivated and removing
Microbial film is cultivated: with reference to ASTME2562-07, cultivated by Pseudomonas aeruginosa (pseudomonasaeruginosa, strain number ATCC15442, derives from Shanghai City Industry Wei Biological Research Institute) microbial film in polycarbonate testing plate.Cultivate and under continuous shear stress condition, carry out 48 hours in CDC biofilm reactor (CBR90-1DH-Int type (BioSurfaceTechnologiesCorp.)).After cultivation, the surface stroke-physiological saline solution of testing plate is rinsed, then testing plate is used for follow-up evaluation.Analyze the total bacterial count (measuring method of total bacterial count is with reference to GB/T4789.2-1994) in unwashed testing plate.For each test, should existing microbial film processed.
The test of microbial film removal rate: the ratio dilution of cleaning compositions water to be tested being pressed 1:400.In the water-bath of 40 DEG C, biomembranous testing plate growth is had to be immersed in sample diluent solution 10 minutes.Take out testing plate and with after stroke-physiological saline solution flushing, by ultrasonic method, residual microbial film be eluted in 20mL stroke-physiological saline solution.Use live bacteria count method (GB/T4789.2-1994 with reference to Standardization Administration of China and Ministry of Health of the People's Republic of China promulgate) analyzes the total bacterial count in physiological saline.Compare with the total bacterial count of the wash-out in unwashed testing plate, calculate microbial film removal rate.
foaming level
Samples with water to be tested for 1.25g is diluted to 500g, obtains the solution of about 500ml volume.With the graduated Domestic fruit extractor of band (such as PhilipsHR1724) firmly stirring 30 seconds.Within 10 seconds, measure the volume of solution after discontinuation of the stirring, to evaluate the foam levels produced.If liquid cleansing composition of the present invention is used for automatic rinser, then preferably foaming level is no more than the composition of 750mL.
nomenclature
example
comparative example 1:
sample preparation:
20gSXS-40 is added in 50g water, then add 2.0gGenapolEP2584,5.0g propylene glycol, 3.0gDuramyl successively.The mixture water of gained is added to 100g, and stirs.
comparative example 2:
25.0gSXS-40 is added in 50g water, then add 15.0gTeric128,5.0g propylene glycol, 3.0gDuramyl and 5.0gAlcalase successively.The mixture water of gained is added to 100g, and stirs.
example 1
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 8.0gAEO-7,5.0g propylene glycol, 0.0008g2-sulfo--4-thiazolinone, 3.0gStainzyme and 7.0gEsperase successively.The mixture water of gained is added to 100g, and stirs.
example 2
8.0gSXS-40 is added in 50g water, stir and make it to dissolve completely; Add 12.0gAEO-7,5.0g propylene glycol, 1.0gKathonCG, 5.0gBAN480L, 10.0gProperase, 1.0gPurafect, 1.0gCarezyme4500 and 2.0gMannastar successively.The mixture water of gained is added to 100g, and stirs.
example 3
8.0gSXS93 is added in 50g water, stir and make it to dissolve completely; Add 15.0gAPEG, 5.0g propylene glycol, 0.04g2-sulfo--4-thiazolinone, 5.0gTermamyl300L, 10.0gSavinase16XL, 2.0gMannaStar successively.The mixture water of gained is added to 100g, and stirs.
example 4
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 15.0gAPEG, 1.0gGenapolEP0244,1.0gDF111,5.0g propylene glycol, 0.04g BIT, 5.0gBAN480L, 10.0gAlcalase, 2.0gPolarzyme, 2.0gLipolase successively.The mixture water of gained is added to 100g, and stirs.
example 5
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 20.0gAEO-7,5.0g propylene glycol, 0.008g2-sulfo--4-thiazolinone, 0.1gStainzyme successively.The mixture water of gained is added to 100g, and stirs.
example 6
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 20.0gAEO-7,5.0g propylene glycol, 0.075g2-sulfo--4-thiazolinone, 0.1gStainzyme successively.The mixture water of gained is added to 100g, and stirs.
example 7
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 1.0gAEO-7,5.0g propylene glycol, 0.075g2-sulfo--4-thiazolinone, 0.1gStainzyme successively.The mixture water of gained is added to 100g, and stirs.
example 8
8.0gSXS-40 is added in 50g water, stir and make it to dissolve completely; Add 12.0gAEO-7,5.0g propylene glycol, 3.0gKathonCG, 3.0gBAN480L, 2.0gProperase, 1.0gMannastar successively.The mixture water of gained is added to 100g, and stirs.
example 9
8.0gSXS-40 is added in 50g water, stir and make it to dissolve completely; Add 19.0gAEO-7,5.0g propylene glycol, 0.5gKathonCG, 5.0gBAN480L, 2.0gProperase, 1.0gMannastar, 1.0Purafect and 1.0gCarezyme4500 successively.The mixture water of gained is added to 100g, and stirs.
example 10
8.0gSXS-40 is added in 50g water, stir and make it to dissolve completely; Add 1.0gAEO-7,5.0g propylene glycol, 0.5gKathonCG, 0.1gBAN480L successively.The mixture water of gained is added to 100g, and stirs.
example 11
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 20.0gAPEG, 5.0g propylene glycol, 0.075g2-sulfo--4-thiazolinone, 1.0gTermamyl300L, 10.0gSavinase16XL, 2.0gMannaStar successively.The mixture water of gained is added to 100g, and stirs.
example 12
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 1.0gAPEG, 5.0g propylene glycol, 0.008g2-sulfo--4-thiazolinone, 5.0gTermamyl300L, 5.0gSavinase16XL, 1.0gMannaStar successively.The mixture water of gained is added to 100g, and stirs.
example 13
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 1.0gAPEG, 5.0g propylene glycol, 0.008g2-sulfo--4-thiazolinone, 0.1gTermamyl300L successively.The mixture water of gained is added to 100g, and stirs.
example 14
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 1.0gAPEG, 1.0gGenapolEP0244,5.0g propylene glycol, 0.08g BIT, 5.0gBAN480L, 1.0gAlcalase, 2.0gPolarzyme and 2.0gLipolase successively.The mixture water of gained is added to 100g, and stirs.
example 15
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 1.0gAPEG, 1.0gGenapolEP0244,1.0gDF111,5.0g propylene glycol, 0.07g BIT, 5.0gBAN480L, 1.0gAlcalase, 2.0gPolarzyme and 2.0gLipolase successively.The mixture water of gained is added to 100g, and stirs.
example 16
8.0gSXS-93 is added in 50g water, stir and make it to dissolve completely; Add 15.0gAPEG, 3.0gGenapolEP0244,1.0gDF111,5.0g propylene glycol, 0.07g BIT, 5.0gBAN480L, 3.0gAlcalase, 2.0gPolarzyme successively.The mixture water of gained is added to 100g, and stirs.
example 17
Add 15.0gAPEG, 0.04g2-sulfo--4-thiazolinone, 5.0gTermamyl300L successively.The mixture water of gained is added to 100g, and stirs.
example 18
According to composition obtaining liq cleaning compositions listed in following table.
Carry out three secondary pollutant film removing tests to example 18, microbial film removal rate is 93.9%, 99.1% and 97.9%.Diluent pH about 8.8, composition is transparent 55 DEG C of maintenances.
As shown in table 2 below, the composition of example 18 can have the shelf life of 2 years under normal storage conditions.
table 2
| Now join | 54 DEG C (2 weeks) | 54 DEG C (4 weeks) | |
| Protease activity (AU/mL) | 0.400 | 0.395 | 0.186 |
| Film test (start, minute) | 4.2 | 3.0 | 3.3 |
| Film test (eccysis, minute) | 6.8 | 5.0 | 5.1 |
As shown in table 1, enzyme is very responsive to general biocide, is usually easy to form precipitation or irreversible sex change occurs immediately.Contriver finds, lytic enzyme, nonionogenic tenside and isothiazolinone can stablize and coexist in liquid cleansing composition of the present invention, and can not produce and precipitate or irreversible sex change occurs.Therefore, the microbial film removal rate higher than 50% (as shown above) can be realized, and the low foaming level (foaming level is lower than the composition of 750mL) being suitable for machine cleaning can be produced.
example 19-26
According to the liquid cleansing composition of the composition preparation example 19-26 shown in table 3.
As shown in table 3, when SAS being elected as the anion surfactant in the system of being added to, diluent keeps the good transparency, and detergency ability is better than the equivalent system containing nonionogenic tenside, and microbial film removal rate is higher than other compositions.
example 27-31
According to the liquid cleansing composition of the composition preparation example 27-31 shown in table 4.
table 4
The extreme ph values that example 29 causes because of DOBS and sex change.
Enzyme is the composition of most fragile in burn-in test.Perform microbial film removing test, to evaluate the stability of composition.At 54 DEG C after aging 3 weeks, example 12 and 13 shows the life-span of prolongation, and example 16 and 17 has the almost identical eccysis time.The diluent of example 31 is transparent at 55 DEG C.
Burn-in test data summarization is in table 5.
table 5
example 32-37
According to the liquid cleansing composition of the composition preparation example 32-37 shown in table 6, shelf life, the result of test also made form.
As shown in table 6, store 3 weeks at 54 DEG C after, protease activity still exceedes 85% of initial value, and this shows that system is stable.
Claims (15)
1. a liquid cleansing composition, comprises:
By the total weight of described composition, at least 1 % by weight and at least one being no more than 20 % by weight is selected from the tensio-active agent of nonionogenic tenside and anion surfactant;
By the total weight of described composition, at least 1 % by weight and be no more than 10 % by weight at least one lytic enzyme;
By the total weight of described composition, at least one of 0.0075 % by weight to 1 % by weight is selected from the compound of isothiazolinone and derivative thereof; And
Water.
2. liquid cleansing composition according to claim 1, wherein said nonionogenic tenside is selected from fatty alcohol alkylene oxide copolymers, polyhydroxy-alcohol and alkylol amide.
3. liquid cleansing composition according to claim 2, wherein said nonionogenic tenside is fatty alcohol alkylene oxide copolymers, is selected from the polymkeric substance containing at least one functional group, and described functional group is selected from oxyethane, propylene oxide and butylene oxide ring.
4. liquid cleansing composition according to claim 1, wherein said at least one lytic enzyme is selected from carbohydrase, proteolytic enzyme and lipase.
5. liquid cleansing composition according to claim 4, wherein said carbohydrase is selected from amylase, cellulase and mannosidase.
6. liquid cleansing composition according to claim 1, wherein said composition comprises at least two kinds of lytic enzymes.
7. liquid cleansing composition according to claim 6, wherein said at least two kinds of lytic enzymes comprise carbohydrase and proteolytic enzyme.
8. liquid cleansing composition according to claim 6, wherein said at least two kinds of lytic enzymes comprise lipase.
9. liquid cleansing composition according to claim 1, wherein said isothiazolinone derivatives is selected from 5-chloro-2-methyl-4-isothiazole and MI.
10. liquid cleansing composition according to claim 1, also comprises at least one solubilizing agent, and described solubilizing agent exists with the amount of 1 % by weight to 40 % by weight of described composition.
11. liquid cleansing compositions according to claim 10, wherein said solubilizing agent is selected from sodium xylene sulfonate or its acid, xylene sulphonic acid sodium or its acid, alkyl amine oxide or their combination.
12. liquid cleansing compositions according to claim 1, wherein said anion surfactant is sulfated alkyl ether.
13. liquid cleansing compositions according to claim 1, wherein said anion surfactant is secondary alkyl sulfonate or alkylether sulfonate.
14. liquid cleansing compositions according to claim 1, wherein said isothiazolinone derivatives is basic structure with isothiazolinone, and introduce halogen, sulphur, hydroxyl or phenyl functional group, or introduce the compound of methyl or ethyl branch.
15. liquid cleansing compositions according to claim 1 or 14, wherein said isothiazolinone derivatives be selected from 5-chloro-2-methyl-4-isothiazolinone, MI and BIT one or more.
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| CN200910137121XA CN101880606B (en) | 2009-05-07 | 2009-05-07 | Liquid cleaning composition with biomembrane removing function |
| CN200910137121X | 2009-05-07 | ||
| CN201510864027.XA CN105368588A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
| CN2010800305688A CN102459557A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107641565A (en) * | 2016-07-22 | 2018-01-30 | 花王株式会社 | Dress material washes agent composition by liquid |
| CN108949296A (en) * | 2018-08-15 | 2018-12-07 | 江苏四新界面剂科技有限公司 | Monocrystalline silicon cutting surfaces activating agent |
| CN111849653A (en) * | 2019-04-28 | 2020-10-30 | 3M创新有限公司 | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103897877A (en) * | 2012-12-26 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | An efficient detergent |
| EP3003035A2 (en) * | 2013-05-28 | 2016-04-13 | Thor Specialities (UK) Limited | Microbicidal composition comprising an isothiazolone and an amineoxide |
| CN103484267B (en) * | 2013-09-12 | 2015-09-16 | 广东环凯微生物科技有限公司 | A kind of special Multi-enzyme detergent of endoscope cleaning-disinfection machine and preparation technology thereof |
| CN104073368A (en) * | 2013-12-05 | 2014-10-01 | 成都老肯科技股份有限公司 | Multi-enzyme cleaning solution suitable for hand-washing medical equipment and preparation method of multi-enzyme cleaning solution |
| CN105838509B (en) * | 2015-01-16 | 2018-04-24 | 3M创新有限公司 | Enzyme solutions, non-woven fabrics containing enzyme and its preparation method and application |
| CN107460060A (en) * | 2017-08-17 | 2017-12-12 | 成都新柯力化工科技有限公司 | A kind of micella osmosis type concentrates quick liquid detergent and preparation method |
| CN111349524A (en) * | 2018-12-21 | 2020-06-30 | 哈尔滨三联药业股份有限公司 | Multienzyme cleaning agent and preparation method and application thereof |
| CN112391241B (en) * | 2019-08-16 | 2022-01-04 | 3M创新有限公司 | Liquid cleaning composition and method of making same |
| CN110846143A (en) * | 2019-11-26 | 2020-02-28 | 河南昊化黎明智能清洗科技有限公司 | Bottle washing additive and preparation method thereof |
| CN113244765B (en) * | 2021-06-10 | 2023-03-24 | 天津大学 | Biomass blocking inhibitor and application thereof |
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| US20020028754A1 (en) * | 2000-07-21 | 2002-03-07 | Novozymes A/S | Antimicrobial compositions |
| US7115550B2 (en) * | 2003-08-28 | 2006-10-03 | Colgate-Palmolive Company | Liquid dish cleaning compositions |
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| US20040101504A1 (en) * | 2001-05-11 | 2004-05-27 | Colgate-Palmolive Company | Mild antibacterial liquid dish cleaning composition having improved stability |
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| US8664173B2 (en) * | 2007-01-11 | 2014-03-04 | Basf Se | Premoistened cleaning disposable substrate for leather and method of preserving a leather surface by contacting said surface with said substrate |
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- 2009-05-07 CN CN200910137121XA patent/CN101880606B/en not_active Expired - Fee Related
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2010
- 2010-05-07 WO PCT/US2010/034044 patent/WO2010129871A1/en active Application Filing
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- 2010-05-07 BR BRPI1007646A patent/BRPI1007646A2/en not_active IP Right Cessation
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020028754A1 (en) * | 2000-07-21 | 2002-03-07 | Novozymes A/S | Antimicrobial compositions |
| US7115550B2 (en) * | 2003-08-28 | 2006-10-03 | Colgate-Palmolive Company | Liquid dish cleaning compositions |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107641565A (en) * | 2016-07-22 | 2018-01-30 | 花王株式会社 | Dress material washes agent composition by liquid |
| CN108949296A (en) * | 2018-08-15 | 2018-12-07 | 江苏四新界面剂科技有限公司 | Monocrystalline silicon cutting surfaces activating agent |
| CN108949296B (en) * | 2018-08-15 | 2021-11-05 | 江苏四新界面剂科技有限公司 | Monocrystalline silicon cutting surfactant |
| CN111849653A (en) * | 2019-04-28 | 2020-10-30 | 3M创新有限公司 | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof |
| CN111849653B (en) * | 2019-04-28 | 2022-03-08 | 3M创新有限公司 | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof |
Also Published As
| Publication number | Publication date |
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| CN102459557A (en) | 2012-05-16 |
| BRPI1007646A2 (en) | 2019-09-24 |
| CN101880606B (en) | 2012-11-21 |
| WO2010129871A1 (en) | 2010-11-11 |
| CN101880606A (en) | 2010-11-10 |
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