CN102459557A - Liquid cleaning composition with biofilm removing function - Google Patents
Liquid cleaning composition with biofilm removing function Download PDFInfo
- Publication number
- CN102459557A CN102459557A CN2010800305688A CN201080030568A CN102459557A CN 102459557 A CN102459557 A CN 102459557A CN 2010800305688 A CN2010800305688 A CN 2010800305688A CN 201080030568 A CN201080030568 A CN 201080030568A CN 102459557 A CN102459557 A CN 102459557A
- Authority
- CN
- China
- Prior art keywords
- cleansing composition
- liquid cleansing
- composition according
- weight
- compsn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/83—Mixtures of non-ionic with anionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
Abstract
A liquid cleaning composition is provided comprising: at least one surfactant selected from the group consisting of a nonionic surfactant and an anionic surfactant; at least one hydrolase; at least one compound selected from the group consisting of isothiazolinone and derivatives thereof; and water.
Description
CROSS-REFERENCE TO RELATED PATENT
The application requires in the right of priority of the one Chinese patent application No.200910137121.X of submission on May 7th, 2009, and this patent is incorporated this paper into way of reference.
Technical field
The present invention relates to have the liquid cleansing composition that microbial film is removed function, specifically, relate in the automatic cleaning of medical apparatus and have the liquid cleansing composition that microbial film is removed function.
Background technology
In the cleaning of medical apparatus, can run into usually such as stains such as human secretion, bloodstain.In addition, under some specific environment, the equipment that for example spends the night or have the instruments of blood or the tube chamber of endoscope, mikrobe is very easy to exist with biomembranous mode.Microbial film has several millimeters to several centimetres nacrostructure, can cover very large zone.In fact, at medical treatment and industrial circle, microbial film is very serious problem.For example, the infection that the equipment of the infection that the formation of plaque, endoscope lens and conduit cause, graft etc. causes, all these usually can form microbial film.Cleaning and disinfectant general method can't be removed microbial film usually effectively, and this can influence the subsequent disposal of utensil unfriendly.
More generally be in automatic rinser, to carry out the cleaning of medicine equipment and relevant device.As far as being used for the sanitising agent of automatic rinser, have higher requirement.
Therefore, a kind of liquid cleansing composition need be provided, it can remove microbial film effectively, and is applicable to automatic rinser.
Summary of the invention
An object of the present invention is to provide a kind of liquid cleansing composition, it can remove microbial film effectively, includes but not limited to be used for automatic rinser.
Unexpectedly, the contriver finds that the liquid cleansing composition comprise tensio-active agent, lytic enzyme and RH-893 and verivate thereof can remove the microbial film on the medical apparatus very effectively.Especially surprisingly, liquid cleansing composition of the present invention can be used for the automatic rinser of medical apparatus especially effectively.
Therefore, the present invention provides the liquid cleansing composition that comprises following composition:
At least a tensio-active agent that is selected from nonionogenic tenside and AS;
At least a lytic enzyme;
At least a compound that is selected from RH-893 and verivate thereof; And
Water.
Liquid cleansing composition of the present invention is particularly useful for cleaning medical apparatus (like medicine equipment and equipment), for example instruments, endoscope, catheter etc.Compsn as herein described also is applicable to family or commercial application, for example air-conditioning, the condensate pipe etc. of cleaning.Liquid cleansing composition of the present invention is significantly removed effect to being difficult to have through the microbial film that ordinary method is removed.Liquid cleansing composition of the present invention also has the outstanding effect of removing to for example stain such as protein, starch.According to the demand, can liquid cleansing composition of the present invention be mixed with the low foam compsn that is applicable to automatic rinser or be mixed with the transparent composition that is applicable to artificial cleaning.
Embodiment
In the present invention; Except as otherwise noted; Otherwise term " microbial film " is meant the microorganism cells set of stiffly adhering to from the teeth outwards and being difficult to remove through simple flushing, and wherein mikrobe mainly encapsulates with the form of extracellular polysaccharide class material or through extracellular polysaccharide class material.After bacterial adhesion was to the material surface, the aqueous polymers structure was with spontaneous generation and concentrate together, was called biomembranous structure thereby form.These attached cells crowd's formation and can cause chronic bacterial infection to the patience of antimicrobial substance.Bacterium in the microbial film is different with corresponding free bacterium aspect physiology.Bacterium in the microbial film exists with cooperative mode, and is closely similar with the many cells life form.
Except as otherwise noted, otherwise term " isothiazolinone derivatives " be meant with RH-893 and add the compound that functional group's (like halogen, sulphur, hydroxyl, carboxyl, phenyl etc.) or interpolation side chain (for example methyl, ethyl etc.) are processed as substruction and through replacement known in the art or addition method.
Except as otherwise noted, otherwise term " Fatty Alcohol(C12-C14 and C12-C18) " has the ROH general formula.R is generally C
8-C
18, and be preferably C
12-C
18Hydroxyl.Such high fatty alcohol has amphipathic, that is to say, molecule not only has hydrophobic grouping (for example carbon-hydrogen chain), also has hydrophilic radical (for example hydroxyl).
For a person skilled in the art, term " oxirane " is known.Example comprises oxyethane.Terepthaloyl moietie has HOC
2H
2The OH structure, wherein condensation reaction can directly take place in hydroxyl.Take place if this is reflected between two terepthaloyl moietie, then form ethylene glycol polymer; Take place if this is reflected between the hydroxyl of two ends of same glycol molecule, then form ring shaped molecule structure, i.e. oxyethane.This structure chemically be not very stable, tends to open loop and other substance reactions.
Except as otherwise noted, otherwise term " lytic enzyme " is meant the enzyme that acts on substrate (reaction object) through hydrolysis reaction.
Except as otherwise noted, otherwise term " carbohydrase " is meant the enzyme of hydrolyzable glucide.The glucide of this paper not only comprises with the carbohydrate of glucose unit as elementary cell, also comprises the polyhydroxy substance part.
Except as otherwise noted, otherwise term " glycase " is meant the enzyme of hydrolyzable starch.For example, the Stainzyme of Novozymes Co., Termamyl 300L, BAN 480L and Duramyl.
Except as otherwise noted, otherwise term " lypase " is meant the enzyme of hydrolyzable lipoid material.For example, the Purafect of the Lipolase of Novozymes Co. and Genencor Co..
Except as otherwise noted, otherwise term " proteolytic enzyme " is meant the enzyme of hydrolyzable protein matter.The for example Alcalase of Novozymes Co., Esperase, Everlase, Savinase 16XL, Liquanase and Polarzyme; And the Properase of Genencor Co..
Can be used for " cellulase " commercially available acquisition of compsn as herein described, for example Carezyme 4500 and the Endolase of Novozymes Co..
Except as otherwise noted, otherwise term " nonionogenic tenside " be meant and in the aqueous solution, do not produce the ionic tensio-active agent.
Except as otherwise noted, otherwise term " Kathon " is the mixture of 5-chloro-2-methyl-4-RH-893 and 2-methyl-3-RH-893, the Kathon CG that for example buys from Rohm Haas Co..
Especially, the present invention provides the liquid cleansing composition that comprises following composition:
At least a tensio-active agent that is selected from nonionogenic tenside and AS;
At least a lytic enzyme;
At least a compound that is selected from RH-893 and verivate thereof; And
Water.
In some preferred embodiments, nonionogenic tenside is selected from Fatty Alcohol(C12-C14 and C12-C18) alkylene oxide copolymers, polyhydroxy-alcohol and alkylol amide.
In a preferred embodiment, nonionogenic tenside is the Fatty Alcohol(C12-C14 and C12-C18) alkylene oxide copolymers.More preferably, nonionogenic tenside is selected from and comprises the polymkeric substance that at least one is selected from the functional group of oxyethane, propylene oxide and butylene oxide ring.More preferably, the cloud point of nonionogenic tenside is in 10 ℃ to 60 ℃ scope.
In a preferred embodiment, the Fatty Alcohol(C12-C14 and C12-C18) alkylene oxide copolymers accounts for the 1-20 weight % of compsn.
According to some embodiment, said at least a tensio-active agent is an AS.Not restriction of kind to AS.For example, in some preferred embodiments, sulfated alkyl ether can be used as AS.In some other preferred embodiments, secondary alkyl sulfonate or alkylether sulfonate are used as AS.
In a preferred embodiment, by the gross weight of compsn, nonionogenic tenside or AS account at least 1 weight %.In a preferred embodiment, by the gross weight of compsn, nonionogenic tenside or AS are no more than 20 weight %.
In a preferred embodiment, said at least a lytic enzyme is selected from carbohydrase, proteolytic enzyme and lypase.More preferably, carbohydrase is selected from glycase, cellulase and mannosidase.In preferred embodiment, compsn comprises at least two kinds of lytic enzymes.Even more preferably, said at least two kinds of lytic enzymes comprise carbohydrase and proteolytic enzyme.Also more preferably, said at least two kinds of lytic enzymes comprise lypase.
In a preferred embodiment, by the gross weight of compsn, lytic enzyme accounts at least 1 weight %.In a preferred embodiment, by the gross weight of compsn, lytic enzyme is no more than 10 weight %.
In a preferred embodiment, add the Antimicrobe compound that is selected from RH-893 and verivate thereof.More preferably, RH-893 and verivate thereof comprise 5-chloro-2-methyl-4-isothiazole and 2-methyl-3-RH-893.
In a preferred embodiment, by the gross weight of compsn, RH-893 and verivate thereof account at least 0.0075 weight %.In a preferred embodiment, by the gross weight of compsn, RH-893 and verivate thereof are no more than 1 weight %.
In a preferred embodiment, liquid cleansing composition also comprises at least a solubilizing agent.Preferably, solubilizing agent is selected from sodium xylene sulfonate or its acid, xylene sulphonic acid sodium or its acid or alkyl amine oxide or their combination.In a preferred embodiment, solubilizing agent accounts for the 1-40 weight % of compsn.
According to some embodiment, liquid cleansing composition of the present invention comprises:
A) solubilizing agent: (for example sodium xylene sulfonate 40 or alkyl amine oxide) 12%-40%;
B) nonionogenic tenside: (for example, Fatty Alcohol(C12-C14 and C12-C18)-alkylene oxide copolymers) 0%-20%;
C) AS: (for example, sulfated alkyl ether) 0%-20%;
D) enzymic activity stablizer: (for example, borax) 1%-10%;
E) biocide: (for example, 5-chloro-2-methyl-4-isothiazole and 2-methyl-3-RH-893) 0.0075%-0.045%;
F) enzyme 1: (for example, glycase) 1-10%;
G) enzyme 2: (for example, proteolytic enzyme) 0-10%;
H) enzyme 3: (for example, Mierocrystalline cellulose) 0-5%;
I) enzyme 4: (for example, Lipolase) 0-5% and
J) have water, and usually add totally 100% to by the gross weight of compsn, prerequisite is that the total amount of nonionogenic tenside and AS is no more than 20%.
Liquid cleansing composition of the present invention can use after diluting 10 to 2,000 times.It is preferred diluting 400 times.Compsn also can directly sold the client as product after the dilution.
Microbial film
Though be reluctant to receive the restriction of any theory; But the contriver believes that liquid cleansing composition of the present invention can be removed the synergy that biomembranous reason possibly be based on the three kinds of components (being tensio-active agent, lytic enzyme and RH-893 or derivatives thereof) in the present composition with mode efficiently like this.The contriver believes, in liquid cleansing composition of the present invention, depends on this synergy; Tensio-active agent can be removed biomembranous outside stain; The RH-893 or derivatives thereof can kill activated bacterial, but the enzyme extracellular polysaccharide structure of disrupting biofilm then is as shown in Figure 1.
In the microbial film of reality, can comprise a large amount of dissimilar mikrobes or with the mikrobe of some type mikrobe as major microorganisms.In experimental evaluation of the present invention, adopt Pseudomonas aeruginosa (pseudomonas aeruginosa) typically.Cultural method then according to ASTM E-2562-07 (
Http:// astm.nufu.eu), wherein in CDC biofilm reactor (CBR 90-1DH-Int type (BioSurface Technologies Corp.)), cultivating under the shearing condition continuously.
Infiltration is the main pattern of microbial film cleaning operation, and its program is cleaned similar with actual manual work.The mobile generation mechanical effect of water is passed through in the cleaning of automatic rinser (for example), and can strengthen biomembranous removing to a certain extent.
Enzyme
Enzyme has multiple sorting technique.The enzyme of sanitising agent is generally lytic enzyme, that is, enzyme is realized cleaning performance through the hydrolysis spot.Lytic enzyme has the effect of effectively removing to the extracellular polysaccharide that forms biofilm structure, therefore can promote biomembranous removing.
The example of lytic enzyme includes but not limited to carbohydrase, proteolytic enzyme, lypase and oxydo-reductase etc.Carbohydrase and proteolytic enzyme are preferred, and glycase and mannosidase are especially preferred.
Can be used for the commercially available acquisition of carbohydrase of the present invention.Carbohydrase can comprise glycase, Mierocrystalline cellulose and other sensu lato poly-hydroxy glucide lytic enzymes.
Can be used for glycase of the present invention is hydrolyzed into the starch based spot and has low-molecular-weight relatively sugar.Suitable glycase includes but not limited to Stainzyme, Termamyl 300L, BAN 480L, the Duramyl of Novozymes Co..
Can be used for lypase of the present invention the oils spot is hydrolyzed into monoglyceride, triglyceride, lipid acid and glycerine.Suitable lypase includes but not limited to the Lipolase of Novozymes Co., the Purafect of Genencor Co..
Can be used for proteolytic enzyme of the present invention and can the albumen spot be hydrolyzed into peptide and amino acid to remove bloodstain effectively.Suitable proteolytic enzyme includes but not limited to Alcalase, Esperase, Everlase, Savinase 16XL, Liquanase, the Polarzyme of Novozymes Co.; The Properase of Genencor Co..
In a preferred embodiment, liquid cleansing composition of the present invention comprises and is used for the medical facilities cleaning to strengthen the proteolytic enzyme of rendeing a service.Can be used for the commercially available acquisition of Mierocrystalline cellulose of the present invention, for example Carezyme 4500, the Endolase of Novozymes Co..
Enzyme is very responsive to general biocide, is easy to form deposition usually or irreversible sex change takes place immediately.The contriver finds that lytic enzyme, tensio-active agent and RH-893 can be used as the stabilized mixture coexistence of liquid cleansing composition of the present invention, and can not produce deposition or irreversible sex change takes place.
Nonionogenic tenside
Term " nonionogenic tenside " is meant the tensio-active agent that in the aqueous solution, does not produce ion (or its amount can be ignored).Preferably, at least a nonionogenic tenside is selected from Fatty Alcohol(C12-C14 and C12-C18) alkylene oxide copolymers, polyhydroxy-alcohol and alkylol amide.
When using the oxirane tensio-active agent, the carbonatoms of oxirane is preferably 2-5, preferred 2-4.
Term " polyhydroxy-alcohol " is meant C
nH
2n+2-x(OH)
x(x>=3), n>=3, preferably 3≤n≤100.
In the present invention, term " alkylol amide " is meant RCONH (C
nH
2nO) H or RCON (C
nH
2nO)
2, wherein R representes C
8～18Alkyl (propping up) chain, preferred C
10～14Alkyl (propping up) chain; 2≤n≤4.
In one embodiment, the verivate (for example AEO) that can be used for Fatty Alcohol(C12-C14 and C12-C18) of the present invention is for having the nonionogenic tenside of general formula A (EO) n, and wherein A representes alkyl, is generally C
8-C
18, preferred C
12-C
18Alkyl, EO are represented divinyl ether group (C
2H
4O), n representes the polymerization degree of EO, and 3≤n≤100.Another kind of fatty alcohol polyoxyalkylene ether has for example RO (C
2H
4O)
a(C
3H
6O)
b(C
4H
8O)
cStructural formula; Wherein R representes C
8-C
18Alkyl (propping up) chain, a, b, c make a+b+c>=3 respectively in the scope of 0-100.
Especially, ionic surfactant pack of the present invention is drawn together but is not limited to Genapol EP0244, Genapol ED 3060, Genapol BE 2410 and the Genapol UD/X/T series of Clariant Chemcials; The DF104 of Dow Chemical and DF123; And the Monamid716 of Croda Co..
A preferred property of nonionogenic tenside is the cloud point that has by its constitutional features decision.When the temperature of the aqueous solution of nonionogenic tenside raise, the wetting ability of solution weakened because of the destruction of hydrogen bond, and therefore, solution becomes white opacity solution, for example milk sap from initial clear solution.Yet this change is a reversible, and when temperature reduced, solution became vitreous state again.Form the polyether-type nonionic tensio-active agent through one or more that adds terepthaloyl moietie, Ucar 35 and butyleneglycol; The polyether-type nonionic tensio-active agent of cloud point in 10-60 ℃ of scope for example; Low temperature and low foam characteristic can be obtained, also good relatively cleansing power can be obtained simultaneously.Can the nonionogenic tenside of other types be used as additive to strengthen the stability of system.
AS
AS does not have cloud point because of its structure.The liquid cleansing composition of the present invention that comprises AS can keep transparent artificial cleaning of apparatus in the used TR (for example 25 to 50 ℃).
According to some embodiment, said at least a tensio-active agent is an AS.Can use any AS.For example, in some preferred embodiments, sulfated alkyl ether can be used as AS.In some other preferred embodiments, secondary alkyl sulfonate or alkylether sulfonate are used as AS.
RH-893 and verivate thereof
The bacterial antibiotic of in microbial film, growing and the patience of sanitas are far above corresponding free bacterium, and its patience will strengthen along with the increase of microbial film formation time.The contriver finds that in the combination of components of liquid cleansing composition of the present invention, RH-893 and verivate thereof can effectively kill the bacterium that grows in the microbial film.Although have no intention to accept the constraint of opinion, it is believed that RH-893 and verivate thereof can combine to realize germicidal action between bacterium and algae protein through destroying.When contacting with mikrobe, the RH-893 or derivatives thereof can suppress rapidly and under most of situation, irreversibly suppress microbial growth, thereby causes these microorganism cellss dead.Therefore, RH-893 and verivate thereof have very strong antibacterial and germicidal action to bacterium, fungi, algae etc.
The structural formula of RH-893 is as follows with preferred isothiazolinone derivatives.
RH-893 5-chloro-2-methyl-4-RH-893
2-methyl-3-RH-893 benzisothiazole ketone
Bubble
Automatic rinser has high relatively requirement to the foaming level usually.Machine will be disturbed by too high foam volume, thereby give the alarm.If liquid cleansing composition of the present invention is used for automatic rinser, then preferably foaming level is no more than the compsn of 750mL, as recording through the laboratory foaming level measurement method in the instance.
The present invention will combine following instance to describe in more detail.Yet, should be pointed out that to the invention is not restricted to these instances.In hereinafter the instance and comparative example, except as otherwise noted, otherwise all umbers, ratio and per-cent are all by weight, and temperature is by a degree centigrade expression.
Testing method
Microbial film is cultivated and is removed
Microbial film is cultivated: with reference to ASTM E2562-07, Pseudomonas aeruginosa (pseudomonas aeruginosa, strain number ATCC 15442 derives from the Shanghai City Industry Wei Biological Research Institute) microbial film is cultivated on the polycarbonate testing plate.Cultivation was being carried out 48 hours under the shearing condition in CDC biofilm reactor (CBR 90-1DH-Int type (BioSurface Technologies Corp.)) continuously.After the cultivation, the surface of testing plate is washed with SPSS, then testing plate is used for follow-up evaluation.Analyze the total bacterial count (measuring method of total bacterial count is with reference to GB/T4789.2-1994) on the unwashed testing plate.For each test, should make microbial film at present.
Microbial film is removed the test of rate: with cleaning compsns water to be tested ratio dilution by 1: 400.In 40 ℃ water-bath, there is biomembranous testing plate to be immersed in the diluted sample solution 10 minutes growth.Take out testing plate and, residual microbial film is eluted in the 20mL SPSS through ultrasonic method with after the SPSS flushing.Use live bacteria count method (with reference to the GB/T 4789.2-1994 of Standardization Administration of China and Ministry of Health of the People's Republic of China's promulgation) to analyze the total bacterial count in the saline water.Compare with the total bacterial count of the wash-out on the unwashed testing plate, calculate microbial film and remove rate.
The foaming level
The samples with water that 1.25g is to be tested is diluted to 500g, obtains the solution of about 500ml volume.Firmly stirred 30 seconds with having graduated family expenses juicer (for example Philips HR1724).Stopping to stir the volume of measuring solution in back 10 seconds, so that estimate the foam levels that produces.If liquid cleansing composition of the present invention is used for automatic rinser, then preferably foaming level is no more than the compsn of 750mL.
Nomenclature
Instance
Comparative example 1:
The sample preparation:
20g SXS-40 is added in the 50g water, add 2.0g Genapol EP 2584,5.0g Ucar 35,3.0g Duramyl then successively.The mixture water of gained is added to 100g, and stirs.
Comparative example 2:
25.0g SXS-40 is added in the 50g water, add 15.0g Teric 128,5.0g Ucar 35,3.0g Duramyl and 5.0g Alcalase then successively.The mixture water of gained is added to 100g, and stirs.
Instance 1
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 8.0gAEO-7,5.0g Ucar 35,0.0008g 2-sulfo--4-thiazolinone, 3.0g Stainzyme and 7.0gEsperase successively.The mixture water of gained is added to 100g, and stirs.
Instance 2
8.0g SXS-40 is added in the 50g water, and stirring makes it to dissolve fully; Add 12.0gAEO-7,5.0g Ucar 35,1.0g Kathon CG, 5.0g BAN 480L, 10.0g Properase, 1.0g Purafect, 1.0g Carezyme 4500 and 2.0g Mannastar successively.The mixture water of gained is added to 100g, and stirs.
Instance 3
8.0g SXS93 is added in the 50g water, and stirring makes it to dissolve fully; Add 15.0gAPEG, 5.0g Ucar 35,0.04g 2-sulfo--4-thiazolinone, 5.0g Termamyl 300L, 10.0g Savinase 16XL, 2.0g MannaStar successively.The mixture water of gained is added to 100g, and stirs.
Instance 4
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 15.0gAPEG, 1.0g Genapol EP0244,1.0g DF111,5.0g Ucar 35,0.04g benzisothiazole ketone, 5.0g BAN 480L, 10.0g Alcalase, 2.0g Polarzyme, 2.0g Lipolase successively.The mixture water of gained is added to 100g, and stirs.
Instance 5
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 20.0gAEO-7,5.0g Ucar 35,0.008g 2-sulfo--4-thiazolinone, 0.1g Stainzyme successively.The mixture water of gained is added to 100g, and stirs.
Instance 6
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 20.0gAEO-7,5.0g Ucar 35,0.075g 2-sulfo--4-thiazolinone, 0.1g Stainzyme successively.The mixture water of gained is added to 100g, and stirs.
Instance 7
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 1.0gAEO-7,5.0g Ucar 35,0.075g 2-sulfo--4-thiazolinone, 0.1g Stainzyme successively.The mixture water of gained is added to 100g, and stirs.
Instance 8
8.0g SXS-40 is added in the 50g water, and stirring makes it to dissolve fully; Add 12.0gAEO-7,5.0g Ucar 35,3.0g Kathon CG, 3.0g BAN 480L, 2.0g Properase, 1.0g Mannastar successively.The mixture water of gained is added to 100g, and stirs.
Instance 9
8.0g SXS-40 is added in the 50g water, and stirring makes it to dissolve fully; Add 19.0gAEO-7,5.0g Ucar 35,0.5g Kathon CG, 5.0g BAN 480L, 2.0g Properase, 1.0g Mannastar, 1.0Purafect and 1.0g Carezyme 4500 successively.The mixture water of gained is added to 100g, and stirs.
Instance 10
8.0g SXS-40 is added in the 50g water, and stirring makes it to dissolve fully; Add 1.0gAEO-7,5.0g Ucar 35,0.5g Kathon CG, 0.1g BAN 480L successively.The mixture water of gained is added to 100g, and stirs.
Instance 11
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 20.0gAPEG, 5.0g Ucar 35,0.075g 2-sulfo--4-thiazolinone, 1.0g Termamyl 300L, 10.0g Savinase 16XL, 2.0g MannaStar successively.The mixture water of gained is added to 100g, and stirs.
Instance 12
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 1.0gAPEG, 5.0g Ucar 35,0.008g 2-sulfo--4-thiazolinone, 5.0g Termamyl 300L, 5.0g Savinase 16XL, 1.0g MannaStar successively.The mixture water of gained is added to 100g, and stirs.
Instance 13
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 1.0gAPEG, 5.0g Ucar 35,0.008g 2-sulfo--4-thiazolinone, 0.1g Termamyl 300L successively.The mixture water of gained is added to 100g, and stirs.
Instance 14
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 1.0gAPEG, 1.0g Genapol EP0244,5.0g Ucar 35,0.08g benzisothiazole ketone, 5.0gBAN 480L, 1.0g Alcalase, 2.0g Polarzyme and 2.0g Lipolase successively.The mixture water of gained is added to 100g, and stirs.
Instance 15
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 1.0gAPEG, 1.0g Genapol EP0244,1.0g DF111,5.0g Ucar 35,0.07g benzisothiazole ketone, 5.0g BAN 480L, 1.0g Alcalase, 2.0g Polarzyme and 2.0g Lipolase successively.The mixture water of gained is added to 100g, and stirs.
Instance 16
8.0g SXS-93 is added in the 50g water, and stirring makes it to dissolve fully; Add 15.0gAPEG, 3.0g Genapol EP0244,1.0g DF111,5.0g Ucar 35,0.07g benzisothiazole ketone, 5.0g BAN 480L, 3.0g Alcalase, 2.0g Polarzyme successively.The mixture water of gained is added to 100g, and stirs.
Instance 17
Add 15.0g APEG, 0.04g 2-sulfo--4-thiazolinone, 5.0g Termamyl 300L successively.The mixture water of gained is added to 100g, and stirs.
Instance 18
According to composition obtaining liq cleaning compsns listed in the following table.
| Chemical name | Instance 18 |
| Weight % | |
| SXS?40 | 20 |
| AEO23 | 15 |
| Kathon?CG | 1.5 |
| Savinase?Ultra?16XL | 7 |
| Lipolase?100L | 0.1 |
| Carezyme?4500L | 0.07 |
| Termamyl?300L | 5 |
| 5%CaCl2 solution | 0.5 |
| Borax | 3 |
| Deionized water | In right amount to 100 |
Instance 18 is carried out three secondary pollutant films remove test, the microbial film rate of removing is 93.9%, 99.1% and 97.9%.Diluent pH is about 8.8, and compsn is transparent 55 ℃ of maintenances.
As shown in table 2 below, the compsn of instance 18 can have the shelf life in 2 years under normal storage condition.
Table 2
| Join at present | 54 ℃ (2 week) | 54 ℃ (4 week) | |
| Protease activity (AU/mL) | 0.400 | 0.395 | 0.186 |
| The film test (beginning, minute) | 4.2 | 3.0 | 3.3 |
| The film test (eccysis, minute) | 6.8 | 5.0 | 5.1 |
As shown in table 1, enzyme is very responsive to general biocide, is easy to form deposition usually or irreversible sex change takes place immediately.The contriver finds that lytic enzyme, nonionogenic tenside and RH-893 can be stablized coexistence in liquid cleansing composition of the present invention, and can not produce deposition or irreversible sex change takes place.Therefore, can realize being higher than the microbial film of 50% (as above shown in the table) and remove rate, and can produce the low foaming level (the foaming level is lower than the compsn of 750mL) that is suitable for the machine cleaning.
Instance 19-26
Liquid cleansing composition according to the preparation of the composition shown in the table 3 instance 19-26.
As shown in table 3, when the AS SAS elected as in the system of being added to, diluent keeps the good transparency, and detergency ability is superior to containing the equivalent system of nonionogenic tenside, and the microbial film rate of removing is higher than other compsns.
Instance 27-31
Liquid cleansing composition according to the preparation of the composition shown in the table 4 instance 27-31.
Table 4
The extreme pH value sex change that instance 29 causes because of DOBS.
Enzyme is the composition of most fragile in the burn-in test.Carry out microbial film and remove test, to estimate the stability of compsn.After 54 ℃ of down aging 3 weeks, instance 12 and 13 shows the life-span of prolongation, and instance 16 and 17 has the eccysis time much at one.The diluent of instance 31 is down transparent at 55 ℃.
The burn-in test data are summarized in the table 5.
Table 5
Instance 32-37
According to the liquid cleansing composition of the preparation of the composition shown in the table 6 instance 32-37, shelf life, the result of test also processed form.
As shown in table 6, after 3 weeks of storage under 54 ℃, protease activity still surpasses 85% of initial value, and this shows that system is stable.
Claims (19)
1. liquid cleansing composition comprises:
At least a tensio-active agent that is selected from nonionogenic tenside and AS;
At least a lytic enzyme;
At least a compound that is selected from RH-893 and verivate thereof; And
Water.
2. liquid cleansing composition according to claim 1, wherein said nonionogenic tenside is selected from Fatty Alcohol(C12-C14 and C12-C18) alkylene oxide copolymers, polyhydroxy-alcohol and alkylol amide.
3. liquid cleansing composition according to claim 2, wherein said nonionogenic tenside are the Fatty Alcohol(C12-C14 and C12-C18) alkylene oxide copolymers.
4. liquid cleansing composition according to claim 1, wherein by the gross weight of said compsn, said tensio-active agent exists with the amount that is no more than 20 weight %.
5. liquid cleansing composition according to claim 3, wherein said nonionogenic tenside is selected from the polymkeric substance that contains at least one functional group, and said functional group is selected from oxyethane, propylene oxide and butylene oxide ring.
6. liquid cleansing composition according to claim 1, the cloud point of wherein said nonionogenic tenside is in 10 ℃ to 60 ℃ scopes.
7. liquid cleansing composition according to claim 1, wherein said at least a lytic enzyme is selected from carbohydrase, proteolytic enzyme and lypase.
8. liquid cleansing composition according to claim 7, wherein said carbohydrase is selected from glycase, cellulase and mannosidase.
9. liquid cleansing composition according to claim 1, wherein said compsn comprises at least two kinds of lytic enzymes.
10. liquid cleansing composition according to claim 9, wherein said at least two kinds of lytic enzymes comprise carbohydrase and proteolytic enzyme.
11. liquid cleansing composition according to claim 9, wherein said at least two kinds of lytic enzymes also comprise lypase.
12. liquid cleansing composition according to claim 1, wherein said isothiazolinone derivatives are selected from 5-chloro-2-methyl-4-isothiazole and 2-methyl-3-RH-893.
13. liquid cleansing composition according to claim 1, wherein by the gross weight of said compsn, said lytic enzyme exists with the amount that is no more than 10 weight %.
14. liquid cleansing composition according to claim 1, wherein by the gross weight of said compsn, said RH-893 or derivatives thereof exists with the amount of 0.0075 weight % to 1 weight %.
15. liquid cleansing composition according to claim 1 also comprises at least a solubilizing agent.
16. according to the described liquid cleansing composition of aforementioned each claim, wherein said solubilizing agent is selected from sodium xylene sulfonate or its acid, xylene sulphonic acid sodium or its acid, alkyl amine oxide or their combination.
17. according to the described liquid cleansing composition of aforementioned each claim, wherein said solubilizing agent exists with the amount of 1 weight % to 20 weight % of said compsn.
18. liquid cleansing composition according to claim 1, the cloud point of wherein said nonionogenic tenside is greater than 50 ℃.
19. liquid cleansing composition according to claim 1, wherein said AS are sulfated alkyl ether.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510864027.XA CN105368588A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
| CN2010800305688A CN102459557A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910137121XA CN101880606B (en) | 2009-05-07 | 2009-05-07 | Liquid cleaning composition with biomembrane removing function |
| CN200910137121.X | 2009-05-07 | ||
| CN2010800305688A CN102459557A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
| PCT/US2010/034044 WO2010129871A1 (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510864027.XA Division CN105368588A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102459557A true CN102459557A (en) | 2012-05-16 |
Family
ID=43050498
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910137121XA Expired - Fee Related CN101880606B (en) | 2009-05-07 | 2009-05-07 | Liquid cleaning composition with biomembrane removing function |
| CN2010800305688A Pending CN102459557A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
| CN201510864027.XA Pending CN105368588A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910137121XA Expired - Fee Related CN101880606B (en) | 2009-05-07 | 2009-05-07 | Liquid cleaning composition with biomembrane removing function |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510864027.XA Pending CN105368588A (en) | 2009-05-07 | 2010-05-07 | Liquid cleaning composition with biofilm removing function |
Country Status (3)
| Country | Link |
|---|---|
| CN (3) | CN101880606B (en) |
| BR (1) | BRPI1007646A2 (en) |
| WO (1) | WO2010129871A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103484267A (en) * | 2013-09-12 | 2014-01-01 | 广东环凯微生物科技有限公司 | Multienzyme cleaning solution special for endoscope cleaning and disinfection machine and preparation process of multienzyme cleaning solution |
| CN111849653A (en) * | 2019-04-28 | 2020-10-30 | 3M创新有限公司 | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof |
| CN112391241A (en) * | 2019-08-16 | 2021-02-23 | 3M创新有限公司 | Liquid cleaning composition and method of making same |
| CN113244765A (en) * | 2021-06-10 | 2021-08-13 | 天津大学 | Biomass blocking inhibitor and application thereof |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103897877A (en) * | 2012-12-26 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | An efficient detergent |
| EP3003035A2 (en) * | 2013-05-28 | 2016-04-13 | Thor Specialities (UK) Limited | Microbicidal composition comprising an isothiazolone and an amineoxide |
| CN104073368A (en) * | 2013-12-05 | 2014-10-01 | 成都老肯科技股份有限公司 | Multi-enzyme cleaning solution suitable for hand-washing medical equipment and preparation method of multi-enzyme cleaning solution |
| CN105838509B (en) * | 2015-01-16 | 2018-04-24 | 3M创新有限公司 | Enzyme solutions, non-woven fabrics containing enzyme and its preparation method and application |
| CN107641565A (en) * | 2016-07-22 | 2018-01-30 | 花王株式会社 | Dress material washes agent composition by liquid |
| CN107460060A (en) * | 2017-08-17 | 2017-12-12 | 成都新柯力化工科技有限公司 | A kind of micella osmosis type concentrates quick liquid detergent and preparation method |
| CN108949296B (en) * | 2018-08-15 | 2021-11-05 | 江苏四新界面剂科技有限公司 | Monocrystalline silicon cutting surfactant |
| CN111349524A (en) * | 2018-12-21 | 2020-06-30 | 哈尔滨三联药业股份有限公司 | Multienzyme cleaning agent and preparation method and application thereof |
| CN110846143A (en) * | 2019-11-26 | 2020-02-28 | 河南昊化黎明智能清洗科技有限公司 | Bottle washing additive and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020028754A1 (en) * | 2000-07-21 | 2002-03-07 | Novozymes A/S | Antimicrobial compositions |
| US20060122092A1 (en) * | 2003-08-28 | 2006-06-08 | Gregory Szewczyk | Liquid dish cleaning compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040101504A1 (en) * | 2001-05-11 | 2004-05-27 | Colgate-Palmolive Company | Mild antibacterial liquid dish cleaning composition having improved stability |
| US6627589B1 (en) * | 2001-05-11 | 2003-09-30 | Colgate-Palmolive Company | Mild antibacterial liquid dish cleaning compositions containing peroxide having improved stability and stain removal benefits |
| GB2395488A (en) * | 2002-11-22 | 2004-05-26 | Reckitt Benckiser Nv | Stain removal |
| JP5155851B2 (en) * | 2005-04-14 | 2013-03-06 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Cleaning liquid for electric personal care equipment |
| US8664173B2 (en) * | 2007-01-11 | 2014-03-04 | Basf Se | Premoistened cleaning disposable substrate for leather and method of preserving a leather surface by contacting said surface with said substrate |
-
2009
- 2009-05-07 CN CN200910137121XA patent/CN101880606B/en not_active Expired - Fee Related
-
2010
- 2010-05-07 WO PCT/US2010/034044 patent/WO2010129871A1/en active Application Filing
- 2010-05-07 CN CN2010800305688A patent/CN102459557A/en active Pending
- 2010-05-07 BR BRPI1007646A patent/BRPI1007646A2/en not_active IP Right Cessation
- 2010-05-07 CN CN201510864027.XA patent/CN105368588A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020028754A1 (en) * | 2000-07-21 | 2002-03-07 | Novozymes A/S | Antimicrobial compositions |
| US20060122092A1 (en) * | 2003-08-28 | 2006-06-08 | Gregory Szewczyk | Liquid dish cleaning compositions |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103484267A (en) * | 2013-09-12 | 2014-01-01 | 广东环凯微生物科技有限公司 | Multienzyme cleaning solution special for endoscope cleaning and disinfection machine and preparation process of multienzyme cleaning solution |
| CN103484267B (en) * | 2013-09-12 | 2015-09-16 | 广东环凯微生物科技有限公司 | A kind of special Multi-enzyme detergent of endoscope cleaning-disinfection machine and preparation technology thereof |
| CN111849653A (en) * | 2019-04-28 | 2020-10-30 | 3M创新有限公司 | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof |
| CN111849653B (en) * | 2019-04-28 | 2022-03-08 | 3M创新有限公司 | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof |
| CN112391241A (en) * | 2019-08-16 | 2021-02-23 | 3M创新有限公司 | Liquid cleaning composition and method of making same |
| CN112391241B (en) * | 2019-08-16 | 2022-01-04 | 3M创新有限公司 | Liquid cleaning composition and method of making same |
| CN113244765A (en) * | 2021-06-10 | 2021-08-13 | 天津大学 | Biomass blocking inhibitor and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1007646A2 (en) | 2019-09-24 |
| CN101880606B (en) | 2012-11-21 |
| WO2010129871A1 (en) | 2010-11-11 |
| CN101880606A (en) | 2010-11-10 |
| CN105368588A (en) | 2016-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102459557A (en) | Liquid cleaning composition with biofilm removing function | |
| CN1074897C (en) | Germicidal-disinfectant detergent composition | |
| JP3226347B2 (en) | How to clean contact lenses | |
| KR101925429B1 (en) | Enzyme solutions, enzyme-containing nonwoven fabrics, and methods for making and using the same | |
| JP5466782B1 (en) | Cleaning composition | |
| CN102071113B (en) | Condensed multi-enzyme medical cleaning agent | |
| EP0462460B1 (en) | Liquid composition for contact lenses method for cleaning or preserving a contact lens by means of such liquid composition | |
| CN106544164A (en) | A kind of high-effective low foam antibacterial type multienzyme cleaning agent and its preparation technology | |
| CN108350396A (en) | Cleaning and sanitizing composition | |
| CN102947435A (en) | Laundry detergent | |
| CZ214496A3 (en) | Enzyme composition | |
| CN101448399B (en) | Composition of biofilm control agent | |
| US8921294B2 (en) | Cleaning liquid | |
| KR101565097B1 (en) | liquid detergent composition | |
| JP2003529612A (en) | Storage-stable liquid disinfectant concentrate compositions, concentrates contained therein, and methods for protecting quaternary biocides from deactivation | |
| JP5154067B2 (en) | Liquid detergent composition for automatic dishwashers | |
| JPH08224288A (en) | Washing and disinfecting agent for contact lens and method for washing and disinfecting contact lens | |
| JP2011208138A (en) | Detergent for medical device | |
| JP2012180514A (en) | Liquid detergent composition | |
| CN112391241B (en) | Liquid cleaning composition and method of making same | |
| JP2650741B2 (en) | How to clean contact lenses | |
| JP6961114B1 (en) | Detergent composition and cleaning method | |
| JP2002034558A (en) | Stabilized proteolytic enzyme and its usage | |
| CN111849653B (en) | Multienzyme detergent composition containing sarcosine or derivatives thereof and application thereof | |
| US9045718B2 (en) | Residue cleaning composition and method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120516 |