CN113117259A - Detection device - Google Patents
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- CN113117259A CN113117259A CN201911393477.XA CN201911393477A CN113117259A CN 113117259 A CN113117259 A CN 113117259A CN 201911393477 A CN201911393477 A CN 201911393477A CN 113117259 A CN113117259 A CN 113117259A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N7/022—Localised ultrasound hyperthermia intracavitary
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
Abstract
The present invention provides a detection device, including: the device comprises a transmitting unit, a receiving unit and a processing unit, wherein the transmitting unit is used for transmitting detection signals to a focus area at different time intervals; the receiving unit is used for receiving a scattered signal formed by scattering of the detection signal by the tissue in the focus area and sending the scattered signal to the processing unit; the processing unit is used for obtaining characteristic parameters according to the scattering signals, comparing the characteristic parameters corresponding to the scattering signals in different time periods, and judging the change condition of the tissue in the focus area according to the comparison result. The detection device provided by the invention can improve the accuracy of judging the coagulation necrosis of the tissue cells, thereby improving the accuracy of detecting the treatment, and can also shorten the detection time and reduce the detection cost, thereby shortening the treatment time, improving the treatment efficiency and reducing the treatment cost.
Description
Technical Field
The invention relates to the technical field of ultrasonic medical treatment, in particular to a detection device.
Background
The High Intensity Focused Ultrasound (HIFU) technique focuses ultrasonic waves through a focused ultrasound transducer and then penetrates into a human body to form a focal region tissue having a very strong energy in a target region tissue to be treated. By using the thermal effect of the ultrasonic wave, the temperature of the tissue in the focal region can be rapidly raised to over 65 ℃, so that the tissue cells in the tissue in the focal region can be subjected to coagulation necrosis, and the tissue cells outside the tissue in the focal region can not be damaged. By carrying out multiple treatments, one focal region tissue of the target region tissue is treated every time to treat the whole target region tissue needing treatment, thereby realizing the non-invasive treatment of human body tumor or pathological tissue cells.
In contrast to conventional surgery, the monitoring of HIFU therapy is related to the safety and effectiveness of HIFU therapy. At present, the image monitoring means mainly include magnetic resonance imaging and B-ultrasonic imaging, wherein the B-ultrasonic imaging can only monitor and image a two-dimensional plane of the target tissue, and coagulation necrosis generated by HIFU treatment is usually three-dimensional, so that B-ultrasonic imaging monitoring is not completely accurate. In addition, B-ultrasonic imaging is to compare whether there is strong echo in the target tissue in the acoustic image before and after treatment to determine whether there is coagulation necrosis of tissue cells, and there is no clear determination about the cause of strong echo, which also causes inaccurate monitoring of B-ultrasonic imaging. The magnetic resonance imaging scan time is long, the HIFU treatment process is seriously affected, and the magnetic resonance equipment is expensive.
Disclosure of Invention
The present invention is directed to solve at least one of the problems of the prior art, and provides a detection device, which can improve the accuracy of determining the occurrence of coagulative necrosis in tissue cells, thereby improving the accuracy of detection of treatment, and can also shorten the detection time, reduce the detection cost, thereby shortening the treatment time, improving the treatment efficiency, and reducing the treatment cost.
To achieve the object of the present invention, there is provided a detection apparatus comprising: the device comprises a transmitting unit, a receiving unit and a processing unit, wherein the transmitting unit is used for transmitting detection signals to a focus area at different time intervals;
the receiving unit is used for receiving a scattered signal formed by scattering of the detection signal by the tissue in the focus area and sending the scattered signal to the processing unit;
the processing unit is used for obtaining characteristic parameters according to the scattering signals, comparing the characteristic parameters corresponding to the scattering signals in different time periods, and judging the change condition of the tissues in the focus area according to the comparison result.
Preferably, the transmitting unit transmits the detection signal to the focal area a plurality of times in each of the periods;
the processing unit is further configured to select the characteristic parameters corresponding to at least two scattering signals from all the scattering signals in the same time period, integrate the selected characteristic parameters, compare the integrated results in different time periods, and determine a change condition of the tissue in the focus area according to the comparison result.
Preferably, the receiving unit includes a plurality of receiving modules, which are disposed around the focal region and are used for receiving the scattered signals scattered to different directions;
the processing unit is further configured to select the characteristic parameters corresponding to the scattering signals in at least two directions from the scattering signals in all directions received in the same time period, select the characteristic parameters corresponding to at least two scattering signals from each selected direction, integrate the selected characteristic parameters, compare the integrated results in different time periods, and determine a change condition of the tissue in the focus area according to the comparison result.
Preferably, the processing unit is configured to perform primary integration on the feature parameters corresponding to all the scattering signals selected in the same direction in the same time period, perform secondary integration on the results after the primary integration in all the selected directions, compare the results after the secondary integration in different time periods, and determine a change condition of the tissue in the focus area according to the comparison result.
Preferably, the first integration includes calculating an average value of the characteristic parameters corresponding to all the scattering signals in the same direction selected in the same time period.
Preferably, the second integration includes calculating a sum of the results of the first integration in all selected directions.
Preferably, the processing unit is further configured to remove signals other than a focus region signal generated by tissue in the focus region from the scattering signals, obtain the characteristic parameter according to the focus region signal, compare the characteristic parameters corresponding to the focus region signals at different time periods, and determine a change condition of the tissue in the focus region according to a comparison result.
Preferably, a storage module is disposed in the processing unit, a threshold is disposed in the storage module, and the processing unit is configured to compare the comparison result of the characteristic parameters corresponding to the scattering signals at different time periods with the threshold, and determine a change condition of a tissue in the focus area according to the comparison result.
Preferably, the threshold value comprises one or more of a difference threshold value, a ratio threshold value and an integral difference threshold value;
the processing unit is configured to obtain a feature parameter according to the scattering signal, calculate and obtain one or more of a difference value, a ratio value and an integral difference value of the feature parameter corresponding to the scattering signal at different time intervals, compare the difference value with the difference threshold value if the difference value is obtained by calculation, compare the ratio value with the ratio threshold value if the ratio value is obtained by calculation, and compare the integral difference value with the integral difference threshold value if the integral difference value is obtained by calculation; and then, judging the change condition of the tissue in the focus area according to the comparison result.
Preferably, the characteristic parameter includes an amplitude of the focused pulsed acoustic wave.
The invention has the following beneficial effects:
according to the detection device provided by the invention, the emission unit directly emits the detection signal to the focus area, and the scattering signal is formed by scattering the detection signal by the tissue in the focus area, so that the scattering signal can contain the information of the tissue in the focus area, the scattering signal containing the information of the tissue in the focus area is received by the receiving unit and then is sent to the processing unit, the processing unit obtains the characteristic parameters from the scattering signals, compares the characteristic parameters corresponding to the scattering signals at different time periods, and judges the change condition of the tissue in the focus area according to the comparison result. The characteristic parameters are obtained from the scattering signals with the information of the tissues in the focus area, so that the characteristic parameters are directly related to the tissues in the focus area, the comparison results of the characteristic parameters corresponding to the scattering signals in different time periods can more accurately judge the change condition of the tissues in the focus area, the accuracy of judging the coagulation necrosis of the tissue cells can be improved, and the accuracy of detecting the treatment can be improved. In addition, the detection device provided by the invention can judge the change condition of the tissue in the focus area only according to the comparison result of the characteristic parameters corresponding to the scattering signals in different time periods, thereby shortening the treatment time, improving the treatment efficiency and reducing the treatment cost.
Drawings
Fig. 1 is a schematic structural diagram of a front view of a target tissue detected by a detection device according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a top view of a detection device for detecting target tissue according to an embodiment of the present invention;
description of reference numerals:
1-target area tissue; 2-a focal region; 3-a transmitting unit; 4-a receiving module; 5-processing unit.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the following describes the detecting device provided by the present invention in detail with reference to the attached drawings.
As shown in fig. 1-2, the present embodiment provides a detection apparatus including a transmitting unit 3, a receiving unit, and a processing unit 5, wherein the transmitting unit 3 is configured to transmit detection signals to a focus area 2 at different periods; the receiving unit is used for receiving a scattering signal formed by scattering the detection signal by the tissue in the focal region 2 and sending the scattering signal to the processing unit 5; the processing unit 5 is configured to obtain characteristic parameters according to the scattering signals, compare the characteristic parameters corresponding to the scattering signals at different time periods, and determine a change condition of the tissue in the focal region 2 according to a comparison result.
In the detection apparatus provided in this embodiment, the transmitting unit 3 directly transmits the detection signal to the focal region 2, and the scattering signal is formed by scattering the detection signal by the tissue in the focal region 2, so that the scattering signal will have information of the tissue in the three-dimensional space where the focal region 2 is located, the scattering signal having the information of the tissue in the focal region 2 is received by the receiving unit and then sent to the processing unit 5, the processing unit 5 obtains the characteristic parameters from the scattering signals, compares the characteristic parameters corresponding to the scattering signals at different time periods, and determines the change condition of the tissue in the focal region 2 according to the comparison result. The characteristic parameters are obtained from the scattering signals with the information of the tissues in the focal region 2, so that the characteristic parameters are directly related to the tissues in the focal region 2, the comparison results of the characteristic parameters corresponding to the scattering signals in different time periods can more accurately judge the change condition of the tissues in the focal region 2, the accuracy of judging the coagulation necrosis of the tissue cells can be improved, and the accuracy of detecting the treatment can be improved. In addition, the detection device provided in this embodiment can determine the change of the tissue in the focal region 2 only according to the comparison result of the characteristic parameters corresponding to the scattered signals at different time intervals, thereby shortening the treatment time, improving the treatment efficiency, and reducing the treatment cost.
In the present embodiment, the transmitting unit 3 may adopt a High Intensity Focused Ultrasound (HIFU) therapy apparatus integrated with therapy and detection functions, the HIFU therapy apparatus is in a ring shape, and may transmit focused acoustic waves with different energy levels and different output forms at the same frequency, and the types of the output forms include continuous acoustic waves and pulsed acoustic waves, wherein the focused continuous acoustic waves with high energy may be used as therapy signals, the focused pulsed acoustic waves with low energy may be used as detection signals, and the energy of the focused pulsed acoustic waves used as the detection signals is far lower than the energy of the focused continuous acoustic waves used as the therapy signals. This is to allow the tissue in the focal region 2 to undergo coagulation necrosis when the tissue is subjected to the treatment signal, so that the tissue in the focal region 2 is treated, and to allow the detection result to be accurate without changing when the tissue is subjected to the detection signal. The acoustic impedance of the tissue in the focal region 2, which changes due to the influence of the treatment signal, changes, and the change in acoustic impedance influences the characteristics of the detection signal, so that the detection signal can be transmitted before the treatment signal is transmitted and after the treatment signal is transmitted, and the characteristic parameters of the detection signal at two different periods of time before the treatment signal is transmitted and after the treatment signal is transmitted are compared to judge the change of the tissue in the focal region 2 according to the comparison result.
In the present embodiment, the HIFU therapy apparatus integrated with the therapy and detection functions can transmit a therapy signal or a detection signal to a region in the target tissue 1 to be treated at a time to treat or detect the tissue in the region, which is referred to as the focal region 2, and the entire target tissue 1 can be treated by treating the tissue in a different focal region 2 of the target tissue 1 multiple times. Moreover, because the treatment signal and the detection signal transmitted by the HIFU treatment device are both focused sound waves, only the energy and the output form of the sound waves are different, the detection signal and the treatment signal transmitted by the HIFU treatment device can be transmitted to the same focal region 2, so that the accuracy of judging coagulation necrosis of tissue cells can be improved, and the accuracy of detecting treatment can be improved.
The following describes the detection process of the detection device provided in this embodiment in detail by taking the treatment of the tissue in one focal region 2 as an example. Before treatment, a low-energy detection signal of a focused pulse sound wave is transmitted to a focus area 2 to be treated, the focused pulse sound wave is scattered by tissues in the focus area 2, so that a scattered signal is generated, the scattered signal is received by a receiving unit and is transmitted to a processing unit 5, then a high-energy treatment signal of a focused continuous sound wave is transmitted to the focus area 2, so that the tissues in the focus area 2 are treated, after the treatment, the low-energy detection signal of the focused pulse sound wave is transmitted to the focus area 2 again, the receiving unit receives a scattered signal formed by scattering of the detection signal by the tissues in the focus area 2 after the treatment and transmits the scattered signal to the processing unit 5, and at the moment, the processing unit 5 has scattered signals in different periods before and after the treatment. Since the acoustic impedance of the tissue in the focal region 2 before and after treatment changes, and therefore the scattering signals before and after treatment also change, the processing unit 5 can compare the characteristic parameters corresponding to the scattering signals before and after treatment, and determine the change condition of the tissue in the focal region 2 according to the comparison result. If the comparison result shows that the difference between the characteristic parameters corresponding to the scattering signals before and after treatment is large, it indicates that the tissue in the focal region 2 is treated well, and then the other focal regions 2 in the target tissue 1 can be treated, and if the comparison result shows that the difference between the characteristic parameters corresponding to the scattering signals before and after treatment is small, it indicates that the tissue in the focal region 2 is treated poorly, and then the focal region 2 can be treated again and detected at the same time until the difference between the characteristic parameters corresponding to the scattering signals before and after treatment of the focal region 2 is large.
In the present embodiment, the time period refers to a plurality of continuous time instants, and the different time periods are distinguished by whether the transmitting unit 3 transmits the treatment signal between transmitting the detection signals. For example, the transmitting unit 3 transmits the detection signal before treatment, transmits the treatment signal during treatment, and transmits the detection signal after treatment, in the process, the transmitting unit 3 transmits the treatment signal between the detection signals before treatment and after treatment, so that the scattering signal before treatment and the scattering signal after treatment are considered as different time periods before treatment and after treatment, and the scattering signal before treatment and the scattering signal after treatment received by the receiving unit are considered as scattering signals of different time periods.
In this embodiment, the processing unit 5 may adopt a computer processing device including an extraction module, a comparison module, a judgment module and a control module, wherein the extraction module may be configured to obtain the characteristic parameters according to the scattering signals, the comparison module may be configured to compare the characteristic parameters corresponding to the scattering signals at different time periods, the judgment module may be configured to judge the change condition of the tissue in the focal region 2 according to the comparison result, and the control module may control the transmitting unit 3 to transmit the detection signal or the treatment signal. The scattered signal may be received by the receiving unit in the form of a wave, the receiving unit may send the scattered signal to the processing unit 5 in the form of a waveform diagram, in such a waveform diagram, an abscissa is generally a time of the scattered signal, an ordinate is generally a voltage value of the scattered signal, a characteristic parameter of the scattered signal may select an amplitude of a focused pulsed acoustic wave, the amplitude refers to a maximum value of a voltage in such a waveform diagram, and the focal region 2 may be extracted from the waveform diagram of the scattered signal sent to the processing unit 5 by the receiving unit. The type of module included in the processing unit 5 is not limited thereto.
In the present embodiment, the transmission unit 3 transmits a detection signal to the focus area 2 a plurality of times in each period; the processing unit 5 is further configured to select characteristic parameters corresponding to at least two scattering signals from all the scattering signals in the same time period, integrate the selected characteristic parameters, compare the integrated results in different time periods, and determine a change condition of the tissue in the focal region 2 according to the comparison result.
Specifically, the control unit can control the emission unit 3 to emit multiple detection signals to the focus region 2 in each time period, the tissue in the focus region 2 scatters the detection signals each time to form a scattering signal, so as to form a plurality of scattering signals, the processing unit 5 selects characteristic parameters corresponding to at least two scattering signals from all the scattering signals in the same time period and integrates the selected characteristic parameters, so as to avoid the occurrence of inaccurate reflection of the tissue condition in the focus region 2 due to possible error of the characteristic parameters of one scattering signal, so as to improve the accuracy of the characteristic parameters of the scattering signals in each time period, improve the accuracy of the characteristic parameters of the scattering signals in each time period to reflect the tissue condition in the focus region 2, and enable the comparison results of the characteristic parameters corresponding to the scattering signals in different time periods, the change condition of the tissue in the focal region 2 can be more accurately judged, so that the accuracy of judging the coagulation necrosis of the tissue cells is improved, and the accuracy of detecting the treatment is improved.
In the present embodiment, the receiving unit includes a plurality of receiving modules 4, the plurality of receiving modules 4 are disposed around the focal region 2, and are configured to receive scattering signals scattered in different directions; the processing unit 5 is further configured to select characteristic parameters corresponding to the scattering signals in at least two directions from the scattering signals in all directions received in the same time period, select characteristic parameters corresponding to at least two scattering signals from each selected direction, integrate the selected characteristic parameters, compare the integrated results in different time periods, and determine a change condition of the tissue in the focal region 2 according to the comparison result.
Specifically, a plurality of receiving modules 4 are arranged around the focal region 2, each receiving module 4 receives scattering signals scattered in the same direction, the receiving modules 4 receive scattering signals scattered in different directions and send the scattering signals in different directions to the processing unit 5, the processing unit 5 selects characteristic parameters corresponding to the scattering signals in at least two directions from the scattering signals in all directions received in the same time period, at least two characteristic parameters of the selected scattering signals in each direction are selected and the selected characteristic parameters are integrated, so as to avoid the occurrence of inaccurate tissue condition reflection in the focal region 2 due to possible errors in the characteristic parameters of the scattering signals in one direction, thereby improving the accuracy of the characteristic parameters of the scattering signals in each time period and the accuracy of the characteristic parameters of the scattering signals in each time period in reflecting the tissue condition in the focal region 2, this enables the comparison result of the characteristic parameters corresponding to the scattered signals at different time intervals to more accurately determine the change condition of the tissue in the focal region 2, thereby improving the accuracy of determining the coagulation necrosis of the tissue cells and the accuracy of detecting the treatment.
In this embodiment, a plurality of receiving modules 4 are arranged around the target tissue 1 to be treated.
In this embodiment, the computer processing device adopted by the processing unit 5 may further include an integration module, and the integration module is configured to integrate the characteristic parameters corresponding to the obtained scattering signals in the same time period. The receiving module 4 may employ a sensor capable of receiving an acoustic wave.
In this embodiment, the processing unit 5 is configured to perform primary integration on the feature parameters corresponding to all the scattering signals in the same direction selected in the same time period, perform secondary integration on the results after the primary integration in all the selected directions, compare the results after the secondary integration in different time periods, and determine the change condition of the tissue in the focal region 2 according to the comparison result.
Specifically, the processing unit 5 first performs a first integration on the feature parameters corresponding to all the scattering signals in the same direction selected in the same time period, that is, performs a first integration on the feature parameters obtained from the scattering signals of the same receiving unit in the same time period, and after the first integration, obtains a plurality of first integration results, and the plurality of first integration results respectively correspond to the selected results after the first integration in each direction, and then performs a second integration on the selected results after the first integration in all the directions, that is, performs a second integration on the selected results after the second integration, and obtains a second integration result, and finally compares the results after the second integration in different time periods, and determines the change condition of the tissue in the focal region 2 according to the comparison result, that is, compares the second integration results in different time periods, and judging the change condition of the tissue in the focal region 2 according to the comparison result of the secondary integration results in different time periods.
In this embodiment, the first integration includes calculating an average value of the characteristic parameters corresponding to all the scattering signals in the same direction selected in the same time period. However, the form of one-time integration is not limited thereto.
In this embodiment, the second integration includes calculating the sum of the results of the first integration in all selected directions. However, the form of the secondary integration is not limited thereto.
Specifically, the description will be given by taking an example in which the processing unit 5 selects the characteristic parameters of the scattered signals in three different directions in the same time period, and selects the characteristic parameter of the triple scattered signal in each direction. The characteristic parameters of the triple scatter signals selected in the first direction by the processing unit 5 before the treatment are respectively a1、a2And a3The characteristic parameters of the third scattering signal in the second direction are respectively b1、b2And b3C is the characteristic parameter of the third scattering signal in the third direction1、c2And c3. Firstly, calculating an average value of characteristic parameters of three scattering signals in the same direction:
the average value of the characteristic parameters of the three scattered signals in the first direction is
The average value of the characteristic parameters of the three scattered signals in the second direction is
The average value of the characteristic parameters of the three scattered signals in the third direction is
Then calculating the sum of characteristic parameters corresponding to the scattering signals in the three directions before treatment as T1＝A+B+C；
The characteristic parameters of the triple scatter signals selected by the processing unit 5 in the first direction obtained after the treatment are respectively d1、d2And d3The characteristic parameters of the third scattering signal in the second direction are respectively e1、e2And e3The characteristic parameters of the third-order scattering signals in the third direction are respectively f1、f2And f3. Firstly, calculating an average value of characteristic parameters of three scattering signals in the same direction:
the average value of the characteristic parameters of the three scattered signals in the first direction is
The average value of the characteristic parameters of the three scattered signals in the second direction is
The average value of the characteristic parameters of the three scattered signals in the third direction is
Then calculating the sum of characteristic parameters corresponding to the scattering signals in the three directions before treatment as T2＝D+E+F；
Finally, the results of the second integration over different time periods are compared, i.e. for T1And T2Making a comparison if T2Relative to T1If the change is large, it indicates that coagulation necrosis occurs in the tissue in the focal region 2, and if T is large2Relative to T1If the variation is small, the probability of coagulation necrosis of the tissue in the focal region 2 is small, and the treatment of the focal region 2 can be continued until the secondary integration result after the treatment is relative to T1The variation is large.
In this embodiment, the processing unit 5 selects or integrates the characteristic parameter corresponding to the transmission signal before the treatment as the initial parameter of the focus area, i.e. T is used1As an initial parameter, the characteristic parameter corresponding to the transmission signal selected or integrated by the processing unit 5 after each treatment is the same as the initial parameter (i.e. T)1) The comparison is performed and the change of the tissue in the focal region 2 is determined based on the comparison result.
In the integration process, the first direction, the second direction and the third direction before treatment and the first direction, the second direction and the third direction after treatment may be the same direction or different directions. However, in practical applications, the characteristic parameters of the scattering signals selected by the processing unit 5 in the same time period are not limited to three directions, and may be two directions or more directions, and the scattering signals selected in each direction are not limited to three times, and may be two times or more times.
The average value of the characteristic parameters of the scattering signals in the same direction can be calculated by using a formula
And calculating, wherein X in the formula is the average value of the characteristic parameters of the scattering signals in the same direction, and n is the times of the characteristic parameters of the scattering signals selected in the same direction.
In this embodiment, the computer processing device adopted by the processing unit 5 may further include a calculating module, and the calculating module is configured to calculate an average value of the characteristic parameters corresponding to all the scattering signals in the same direction selected in the same time period, and a sum of results after one integration in all the directions selected.
In the present embodiment, the processing unit 5 is further configured to remove signals other than the focal region 2 signal generated by the tissue in the focal region 2 from the scattered signals, obtain characteristic parameters according to the focal region 2 signal, compare the characteristic parameters corresponding to the focal region 2 signals in different time periods, and determine the change condition of the tissue in the focal region 2 according to the comparison result.
Specifically, after the detection signal is scattered by the tissue in the focal region 2 to form a scattered signal, the scattered signal is not directly received by the receiving unit, but is received by the receiving unit only through a distance between the tissue outside the focal region 2 and the receiving unit, and in the distance, the scattered signal passes through impurities such as normal tissue, skin, air and the like which do not need to be treated, and the impurities affect the waveform of the scattered signal. That is, when the scattered signal is received by the receiving unit in the form of a wave, the scattered signal forms a waveform including a waveform formed by the tissue in the focal region 2, normal tissue which does not need treatment, skin, and impurities such as air. Signals except the focus area 2 signal generated by the tissue in the focus area 2 in the scattering signal are removed through the processing unit 5 to form the focus area 2 signal, so that the condition that the waveform of the scattering signal is formed by impurities such as normal tissue, skin and air which do not need to be treated can be avoided from being selected when the amplitude is selected, the accuracy of characteristic parameter selection is improved, the comparison result of the characteristic parameters corresponding to the scattering signal in different periods can be used for more accurately judging the change condition of the tissue in the focus area 2, the accuracy of judgment of coagulation necrosis of tissue cells is improved, and the accuracy of detection of treatment is improved.
In the present embodiment, the processing unit 5 is provided with a storage module, the storage module is provided with a threshold, the processing unit 5 is configured to compare the comparison result of the characteristic parameters corresponding to the scattering signals of different time periods with the threshold, and determine the change condition of the tissue in the focal region 2 according to the comparison result, and the threshold can be used as the determination T2Relative to T1The variation size can be set according to practical experience, and the corresponding threshold values of different types of target tissues 1 are different.
Specifically, the threshold includes one or more of a difference threshold, a ratio threshold and an integral difference threshold; the processing unit 5 is configured to obtain a feature parameter according to the scattering signal, and calculate one or more of a difference value, a ratio value, and an integral difference value of the feature parameter corresponding to the scattering signal at different time intervals, compare the difference value with a difference threshold value if the difference value is obtained by calculation, compare the ratio value with a ratio threshold value if the ratio value is obtained by calculation, and compare the integral difference value with an integral difference threshold value if the integral difference value is obtained by calculation; then, the change of the tissue in the focal region 2 is determined based on the comparison result. However, the type of the threshold is not limited thereto.
With the difference threshold value being K1The threshold value of the ratio is K2Integral difference threshold of K3The waveform range of the signal in the focal region 2 is S1To S2Summation of characteristic parameters corresponding to the scattered signals selected before treatmentIs T1The sum of the characteristic parameters corresponding to the selected scattering signals after treatment is T2The description is given for the sake of example. Then, the difference value of the characteristic parameters corresponding to the scattering signals in different time periods is T1-T2；
The ratio of the characteristic parameters corresponding to the scattering signals in different time periods is T1/T2；
The integral difference value of the characteristic parameters corresponding to the scattering signals in different time periods is the
If the difference value T is obtained by calculation1-T2Then T will be1-T2And K1Making a comparison if T1-T2Greater than K1If T is T, it indicates that coagulation necrosis occurs in the tissue in the focal region 21-T2Less than or equal to K1If the tissue in the focal region 2 begins to produce coagulation necrosis but the optimal treatment effect is not achieved, the treatment of the focal region 2 can be continued until T1-T2Greater than K1；
If the ratio T is obtained by calculation1/T2Then T will be1/T2And K2Making a comparison if T1/T2Greater than K2If T is T, it indicates that coagulation necrosis occurs in the tissue in the focal region 21/T2Less than or equal to K2If the tissue in the focal region 2 begins to produce coagulation necrosis but the optimal treatment effect is not achieved, the treatment of the focal region 2 can be continued until T1/T2Greater than K2；
If the calculation result is the integral difference value
Then will be
And K3Make a comparison if
Greater than K3If the tissue in the focal region 2 is coagulated necrosed, it is indicated that
Less than or equal to K3If the coagulation necrosis of the tissue in the focal region 2 does not start, the treatment of the focal region 2 can be continued until the tissue in the focal region 2 is treated
Greater than K3。
If a plurality of values of the difference, the ratio and the integral difference of the characteristic parameters corresponding to the scattering signals in different time periods are obtained through simultaneous calculation, if one of the calculation results is greater than the corresponding threshold value, it is indicated that the tissue in the focal region 2 generates coagulation necrosis.
In summary, the detection device provided by the embodiment can improve the accuracy of determining the coagulation necrosis of the tissue cells, thereby improving the accuracy of detection of the treatment, and can also shorten the detection time and reduce the detection cost, thereby shortening the treatment time, improving the treatment efficiency, and reducing the treatment cost.
It will be understood that the above embodiments are merely exemplary embodiments taken to illustrate the principles of the present invention, which is not limited thereto. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit and substance of the invention, and these modifications and improvements are also considered to be within the scope of the invention.
Claims (10)
1. A detection device, comprising: the device comprises a transmitting unit, a receiving unit and a processing unit, wherein the transmitting unit is used for transmitting detection signals to a focus area at different time intervals;
the receiving unit is used for receiving a scattered signal formed by scattering of the detection signal by the tissue in the focus area and sending the scattered signal to the processing unit;
the processing unit is used for obtaining characteristic parameters according to the scattering signals, comparing the characteristic parameters corresponding to the scattering signals in different time periods, and judging the change condition of the tissues in the focus area according to the comparison result.
2. The detection apparatus according to claim 1, wherein the transmission unit transmits the detection signal to the focus area a plurality of times in each of the periods;
the processing unit is further configured to select the characteristic parameters corresponding to at least two scattering signals from all the scattering signals in the same time period, integrate the selected characteristic parameters, compare the integrated results in different time periods, and determine a change condition of the tissue in the focus area according to the comparison result.
3. The detection apparatus according to claim 2, wherein the receiving unit comprises a plurality of receiving modules, which are disposed around the focal region for receiving the scattered signals scattered to different directions;
the processing unit is further configured to select the characteristic parameters corresponding to the scattering signals in at least two directions from the scattering signals in all directions received in the same time period, select the characteristic parameters corresponding to at least two scattering signals from each selected direction, integrate the selected characteristic parameters, compare the integrated results in different time periods, and determine a change condition of the tissue in the focus area according to the comparison result.
4. The detecting device according to claim 3, wherein the processing unit is configured to perform a first integration on the characteristic parameters corresponding to all the scattered signals in the same direction selected in the same time period, perform a second integration on the results of the first integration in all the selected directions, compare the results of the second integration in different time periods, and determine a change condition of the tissue in the focal region according to the comparison result.
5. The detection apparatus according to claim 5, wherein the first integration includes calculating an average value of the characteristic parameters corresponding to all the scattered signals in the same direction selected in the same time period.
6. The detection apparatus according to claim 5, wherein the second integration comprises summing the results of the first integration in all selected directions.
7. The detection apparatus according to any one of claims 1 to 6, wherein the processing unit is further configured to remove signals other than a focal region signal generated by the tissue in the focal region from the scattered signals, obtain the characteristic parameters according to the focal region signal, compare the characteristic parameters corresponding to the focal region signal at different time intervals, and determine a change condition of the tissue in the focal region according to a comparison result.
8. The detection apparatus according to any one of claims 1 to 6, wherein a storage module is disposed in the processing unit, a threshold value is disposed in the storage module, and the processing unit is configured to compare the comparison result of the characteristic parameters corresponding to the scattering signals at different time periods with the threshold value, and determine a change condition of the tissue in the focal region according to the comparison result.
9. The detection apparatus of claim 8, wherein the threshold value comprises one or more of a difference threshold value, a ratio threshold value, and an integral difference threshold value;
the processing unit is configured to obtain a feature parameter according to the scattering signal, calculate and obtain one or more of a difference value, a ratio value and an integral difference value of the feature parameter corresponding to the scattering signal at different time intervals, compare the difference value with the difference threshold value if the difference value is obtained by calculation, compare the ratio value with the ratio threshold value if the ratio value is obtained by calculation, and compare the integral difference value with the integral difference threshold value if the integral difference value is obtained by calculation; and then, judging the change condition of the tissue in the focus area according to the comparison result.
10. The sensing device of any one of claims 1-6, wherein the characteristic parameter comprises an amplitude of a focused pulsed acoustic wave.
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