CN113116750A

CN113116750A - Polyol composition and application thereof in cosmetics

Info

Publication number: CN113116750A
Application number: CN202110473784.XA
Authority: CN
Inventors: 叶少玲; 潘晓燕; 孟丽; 陈凤鸾; 聂舟; 王晓慧
Original assignee: Guangzhou Rui Sen Biotechnology Co ltd
Current assignee: Guangzhou Rui Sen Biotechnology Co ltd
Priority date: 2021-04-29
Filing date: 2021-04-29
Publication date: 2021-07-16

Abstract

The present invention relates to a polyol composition and its use in cosmetics, said polyol composition comprising: panthenol, 1, 2-propanediol, 1, 3-propanediol, and polyethylene glycol. Further, the polyol composition further comprises any one of glycerol, butanediol or 1, 2-hexanediol, or a combination of at least two thereof. Further, the polyol composition further comprises dipropylene glycol and/or pentanediol. The polyalcohol composition is added into skin care matrixes with different effects, so that the problem of transdermal absorption of skin care effect components can be remarkably improved, the efficacy of the product is improved, the absorptivity and moisture retention of the product are improved, the smearing feeling and the sticky feeling of the product are improved, no preservative is required to be added, and the skin care matrix is safe and mild and has no stimulation to skin.

Description

Polyol composition and application thereof in cosmetics

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a polyol composition and application thereof in cosmetics, in particular to a polyol composition with a remarkable permeation promoting effect and application thereof in cosmetics.

Background

The transdermal absorption effect of cosmetics is very important, which is a key point affecting whether cosmetics are effective or not. The prior art relates to a plurality of transdermal penetration promoting components, such as polyalcohol, lipoid, humectant, transdermal enhancing peptide and the like. Wherein the polyhydric alcohol comprises glycerol, propylene glycol, 1, 3-butanediol, 1, 2-hexanediol, pentanediol, etc.; the lipid comprises ceramide, cholesterol, squalane, egg yolk lecithin, soybean lecithin, hydrogenated lecithin, etc.; the humectant comprises bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, caprylic/capric triglyceride, PEG/PPG-14/7 dimethyl ether, hydrolyzed glycosaminoglycans, shea butter, PEG castor oil, etc.; transdermal enhancing peptides include transdermal peptide TD-1, skin and cell penetrating peptide SPACE, dermal localization peptide DLP, leader peptide-12, T2 peptide, etc.

CN112245366A discloses a penetration-promoting composition containing hyaluronic acid and its application in cosmetics, comprising: 2-5 parts of hyaluronic acid, 1-3 parts of bis-diethoxydiol cyclohexane 1, 4-dicarboxylic ester and 8-15 parts of polyhydric alcohol. The hyaluronic acid is a mixture of macromolecular hyaluronic acid, micromolecular hyaluronic acid, cross-linked hyaluronic acid and high-affinity hyaluronic acid, and the mass ratio of the hyaluronic acid to the high-affinity hyaluronic acid is 1 (1-3) to (2-4) to (1-4); the polyhydric alcohol is composed of one or more of glycerol, propylene glycol, polyethylene glycol, sorbitol, 1, 3-butanediol, 1, 2-hexanediol and pentanediol, and preferably glycerol.

CN112336649A discloses a method for preparing skin co-permeation carrier of ceramide and fat-soluble active substance and a product thereof, wherein the skin co-permeation carrier comprises ceramide, fat-soluble active substance, phospholipid, cholesterol, fatty acid, phytosphingosine, liquid lipid, solid lipid, polyalcohol and water. The polyalcohol is one or more of glycerol, butanediol, sorbitol, pentaerythritol and xylitol. The positive charge of the carrier, and the ternary penetration-promoting system (ceramide, cholesterol and fatty acid) can obviously improve the penetration amount of ceramide in the skin stratum corneum, exert the effects of enhancing skin hydration and improving stratum corneum lipid fluidity, further promote the skin penetration of fat-soluble active substances in the carrier and achieve the aim of co-penetration.

CN107441066A discloses a transdermal absorption patch, which comprises a back lining layer, a drug storage layer and a protective layer; wherein the medicine storage layer comprises an adhesive composition, a plasticizer, a penetration enhancer, a moisturizing plasticizer and an active medicine. The penetration enhancer is prepared by combining more than two polyalcohol compounds and at least one lactic acid compound or at least one fatty acid ester compound. The polyol compound includes low-carbon polyol compounds such as 1, 2-propylene glycol, 1, 3-propylene glycol, 1, 2-butylene glycol, 1, 3-butylene glycol, 1, 4-butylene glycol and the like, and polyol polymers which are liquid at normal temperature such as polyethylene glycol 200, 400, 600, polypropylene glycol 200, 400, 600 and the like.

As can be seen from the prior art, the existing penetration enhancer is mainly prepared by compounding polyalcohol and other various components, so that the penetration enhancing effect of the product is achieved, and heavy burden can be caused to the skin. Furthermore, the penetration enhancer has a single function, and cosmetics having an effect of improving the skin are required to have not only a good penetration enhancing effect but also an effect of improving the final effect of the skin in consideration of absorbency, spreadability, stickiness, moisture retention, and the like.

Disclosure of Invention

In view of the deficiencies of the prior art, the present invention aims to provide a polyol composition and its use in cosmetics, in particular a polyol composition having a significant penetration enhancing effect and its use in cosmetics. The polyol composition has a good permeation promoting effect under the condition that the polyol composition is not required to be compounded with other permeation promoting functional components, and helps to improve the absorbability and the moisture retention of a product and reduce the sticky feeling of the product.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the present invention provides a polyol composition comprising: panthenol, 1, 2-propanediol, 1, 3-propanediol, and polyethylene glycol.

The invention creatively combines four specific polyols of panthenol, 1, 2-propylene glycol, 1, 3-propylene glycol and polyethylene glycol to form a polyol composition, and the polyol composition is added into skin care matrixes with different effects, so that the problem of transdermal absorption of skin care effect components can be remarkably improved, the efficacy of the product is improved, the absorbability and the moisture retention of the product are improved, the smearing feeling and the sticky feeling of the product are improved, no additional preservative is required, and the skin care composition is safe and mild and has no stimulation to skin.

Preferably, the mass ratio of the panthenol, the 1, 2-propylene glycol, the 1, 3-propylene glycol and the polyethylene glycol is (1-8): (5-20): 5-20).

When the mass ratio of panthenol, 1, 2-propylene glycol, 1, 3-propylene glycol and polyethylene glycol satisfies the above specific range, the polyol composition has better effects in improving the problem of transdermal absorption of skin care efficacy components, improving the absorbability and moisture retention of the product. And (1-5): (10-20): (10-20): (10-20) is the most significant range of effect.

The term (1-8) means that the specific value can be selected to be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5 or 8, etc.

The (5-20) means that specific values can be selected to be 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 or 20, and the like.

Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

Further preferably, the mass ratio of the panthenol, the 1, 2-propylene glycol and the 1, 3-propylene glycol to the polyethylene glycol is (1-5): (10-20).

Preferably, the polyol composition further comprises any one or a combination of at least two of glycerol, butanediol, or 1, 2-hexanediol; the combination of at least two of the above-mentioned compounds, such as the combination of glycerin and butylene glycol, the combination of butylene glycol and 1, 2-hexanediol, the combination of glycerin and 1, 2-hexanediol, etc., can be selected in any combination manner, and thus, the details are not repeated herein. A combination of glycerol, butylene glycol and 1, 2-hexanediol is preferred.

The effect of improving the skin-care functional component in the aspects of percutaneous absorption, improving the product absorptivity and moisture retention can be further improved by further adding any one or the combination of at least two of glycerin, butanediol or 1, 2-hexanediol into the polyol composition.

Preferably, the mass ratio of glycerol to panthenol is (5-13): (1-8), preferably (5-10): (1-5);

wherein, (1-8) means that the specific value can be selected to be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5 or 8, etc.; (5-13) means that the specific value can be selected to be 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 12, or 13, etc.; other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

Preferably, the mass ratio of the butanediol to the panthenol is (5-15): (1-8), preferably (8-15): (1-5);

wherein, (1-8) means that the specific value can be selected to be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5 or 8, etc.; (5-15) means that the specific value can be selected to be 5, 5.5, 6, 6.5, 7, 7.5, 8, 9, 10, 11, 12, 13, 14, or 15, etc.; other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

Preferably, the mass ratio of the 1, 2-hexanediol to the panthenol is (0.5-3): 1-8, preferably (0.5-2): 1-5.

Wherein, (1-8) means that the specific value can be selected to be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5 or 8, etc.; (0.5-3) means that the specific value can be selected to be 0.5, 1, 1.5, 2, 2.5 or 3, etc.; other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

When the addition amount of the glycerin, the butanediol or the 1, 2-hexanediol meets the specific requirements, the skin-care functional component has better effects on improving the transdermal absorption problem of the skin-care functional component, improving the absorbability of the product and keeping moisture.

Preferably, the polyol composition further comprises dipropylene glycol and/or pentanediol, preferably a combination of dipropylene glycol and pentanediol.

The further addition of dipropylene glycol and/or pentanediol to the aforementioned polyol composition can increase the moisture retention of the composition and improve the skin feel, mildness, and non-irritation of the final product.

The preparation process of the polyol composition is simple, only needs to be simply and uniformly mixed, is convenient to operate, and is very suitable for industrial production.

In a second aspect, the present invention provides the use of a polyol composition as described in the first aspect in the preparation of a cosmetic product.

The polyol composition can be widely used for being added into skin care matrixes with different efficacies, and has good compatibility.

Preferably, the polyol composition is added in an amount of 30-90% in the cosmetic, such as 30%, 40%, 50%, 60%, 70%, 80%, 90%, etc., and other specific values in the numerical range can be selected, which is not described in detail herein. Preferably 40 to 80%, and more preferably 50 to 80%.

In a third aspect, the invention provides a whitening and skin-brightening skin care product, which is prepared from the following raw materials in percentage by mass: the polyol composition of the first aspect is 50-80% (e.g., 50%, 55%, 60%, 65%, 70%, 75%, 80%, etc.), the whitening skin lightening base is 0.1-10% (0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.), water.

Preferably, the whitening and skin-lightening base comprises any one of niacinamide, 3-o-ethyl ascorbic acid, glutathione, ergothioneine, idebene, tocopherol, resveratrol or retinol or a combination of at least two of the same.

In a fourth aspect, the invention provides a moisturizing and skin-care product, which is prepared from the following raw materials in percentage by mass: the polyol composition of the first aspect is 50-80% (e.g., 50%, 55%, 60%, 65%, 70%, 75%, 80%, etc.), the moisturizing base is 0.05-10% (e.g., 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.), water.

Preferably, the moisturizing and moisturizing substrate comprises any one or a combination of at least two of ectoin, sodium hyaluronate, amino acid, sodium alginate, beta-glucan, ceramide, betaine, squalane or jojoba seed oil.

In a fifth aspect, the invention provides a skin-tightening skin care product, which comprises the following raw materials in percentage by mass: the polyol composition of the first aspect can be 50-80% (e.g., 50%, 55%, 60%, 65%, 70%, 75%, 80%, etc.), the firming skin substrate 0.05-10% (e.g., 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.), water.

Preferably, the tightening skin matrix comprises any one of or a combination of at least two of a blue-copper peptide, hydroxy-pinacolone retinoic acid ester, silanediol salicylate, hydrolyzed collagen, hydroxypropyl tetrahydropyran triol, or polypeptide.

Compared with the prior art, the invention has the following beneficial effects:

Detailed Description

To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

The polyethylene glycol referred to in the following examples and comparative examples was polyethylene glycol (Mw ═ 400); the butanediol is 1, 3-butanediol; the pentanediol is 1, 2-pentanediol; ergothioneine was obtained from shanghai ketjen technologies ltd,the model is

Amycopterin

Nicotinamide is available from Longsha under the type Niacinamide feed grade; glutathione is purchased from Viqi technology and has a model number of

PGSH glutathione Plus.

Example 1

This example provides a polyol composition, comprising, by weight, 40g of panthenol, 3 parts of 1, 2-propanediol, 15 parts of 1, 3-propanediol, and 15 parts of polyethylene glycol, wherein the components are uniformly mixed at 25 ℃.

Example 2

This example provides a polyol composition, comprising, by weight, 40g of panthenol, 8 parts of 1, 2-propanediol, 8 parts of 1, 3-propanediol, and 8 parts of polyethylene glycol, wherein the components are uniformly mixed at 25 ℃.

Example 3

This example provides a polyol composition, which comprises, by weight, 40g of a total polyol composition, 3 parts of panthenol, 15 parts of 1, 2-propanediol, 15 parts of 1, 3-propanediol, 15 parts of polyethylene glycol, and 8 parts of glycerol, and the components are uniformly mixed at 25 ℃.

Example 4

This example provides a polyol composition, which comprises, by weight, 40g of a total polyol composition, 3 parts of panthenol, 15 parts of 1, 2-propanediol, 15 parts of 1, 3-propanediol, 15 parts of polyethylene glycol, and 10 parts of butanediol, and the components are uniformly mixed at 25 ℃.

Example 5

This example provides a polyol composition, which comprises, by weight, 40g of panthenol, 15 parts of 1, 2-propanediol, 15 parts of 1, 3-propanediol, 15 parts of polyethylene glycol, and 1.5 parts of 1, 2-hexanediol, and the components are uniformly mixed at 25 ℃.

Example 6

This example provides a polyol composition, which comprises, by weight, 40g of a total polyol composition, 3 parts of panthenol, 15 parts of 1, 2-propanediol, 15 parts of 1, 3-propanediol, 15 parts of polyethylene glycol, 8 parts of glycerol, 10 parts of butanediol, and 1.5 parts of 1, 2-hexanediol, and the components are uniformly mixed at 25 ℃.

Example 7

This example provides a polyol composition, which comprises, by weight, 40g of a total polyol composition, 3 parts of panthenol, 15 parts of 1, 2-propanediol, 15 parts of 1, 3-propanediol, 15 parts of polyethylene glycol, 8 parts of glycerol, 10 parts of butanediol, 1.5 parts of 1, 2-hexanediol, 3 parts of dipropylene glycol, and 2 parts of pentanediol, and the components are uniformly mixed at 25 ℃.

Comparative example 1

This comparative example provides a total mass of 40g of panthenol.

Comparative example 2

This comparative example provides a total mass of 40g of 1, 2-propanediol.

Comparative example 3

This comparative example provides a total mass of 40g of 1, 3-propanediol.

Comparative example 4

This comparative example provides a total mass of 40g of polyethylene glycol.

Comparative example 5

This comparative example provides a polyol composition having a total mass of 40g and consisting of the same components as in example 1 except that panthenol was replaced with sorbitol of equal mass, and the other conditions were kept unchanged. The components are mixed evenly at 25 ℃.

Comparative example 6

This comparative example provides a polyol composition having a total mass of 40g and consisting of the same components as in example 1 except that panthenol was replaced with glycerol of equal mass, and the other conditions were kept unchanged. The components are mixed evenly at 25 ℃.

Application example 1

The application example provides a whitening and skin-brightening skin-care essence which comprises, by mass, 70% of the polyol composition prepared in example 1, 3% of nicotinamide, 0.5% of glutathione, 0.5% of ergothioneine and deionized water to make up to 100%.

The preparation method comprises the following steps:

(1) firstly, heating water to 85 ℃, preserving heat for 30min, and then sterilizing;

(2) then cooling to 45 ℃, adding the mixed polyol composition, and stirring uniformly;

(3) finally, the nicotinamide, the glutathione and the ergothioneine are added, the temperature is restored to 25 ℃, and qualified discharge is carried out.

Application examples 2 to 7

The present application example provides six kinds of whitening and skin-lightening skin care essences, which are different from the application example 1 only in that the polyol composition prepared in example 1 was replaced with the polyol compositions prepared in examples 2 to 7, and the others were kept unchanged. The preparation method is the same as in application example 1.

Comparative application examples 1 to 6

The comparative application example provides six kinds of whitening and skin-brightening skin care essences, the components of which are different from those of application example 1 only in that the polyol composition prepared in example 1 is replaced by the polyol compositions prepared in comparative examples 1-6, and the others are kept unchanged. The preparation method is the same as in application example 1.

Comparative application example 7

The comparative application example provides a whitening and skin-brightening skin care essence which is different from the application example 1 only in that the polyol composition prepared in the example 1 is not contained, and the rest of the essence are kept unchanged.

Test example 1

Safety tests were performed on the whitening, skin-lightening and skin-care essences of application examples 1 to 7 and comparative application examples 1 to 7:

selecting 42 volunteers with ages of 25-40 years for testing, randomly dividing the volunteers into 14 groups, 3 persons in each group, distributing a sample for each group of volunteers to carry out a closed spot-sticking test, dripping about 0.025mL of a tested sample into a spot tester, externally applying a special adhesive tape to the back of the test subject, removing the tested sample after 24 hours, observing skin reactions after 0.5, 24 and 48 hours after the removal respectively, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).

The result of the human body skin patch test shows that: adverse reactions to skin appear in 0 cases, which shows that the whitening and skin-brightening skin-care essence disclosed by the invention is safe and non-irritant to skin.

Test example 2

The whitening and skin-brightening skin care essences of application examples 1 to 7 and comparative application examples 1 to 7 were subjected to a whitening and skin-brightening efficacy test:

the experimental principle is as follows: the change in skin color can be measured using a skin complexion measuring instrument. The currently widely adopted measuring method for quantifying skin color is to measure the change of skin color by a colorimetric system (Lab colorimetric system) specified by the International Commission on illumination (CIE), and the method has accurate quantification, can reflect the multidimensional change of a skin color space, and ensures that the skin color is quantified more reliably. The test indexes are the MI value of the skin melanin content (the higher the measured value is, the higher the melanin content in the skin is), the L value of the skin whiteness/brightness and the ITA degree (the L value indicates that L is white balance, the larger the value is, the more white the color is, the ITA degree value is the individual type angle of the skin, and the larger the ITA degree value is, the brighter the skin). Therefore, the whitening effect of the cosmetic can be judged by measuring the melanin content of the skin stratum corneum and the skin chromaticity.

△MI＝T_n-T₀(ii) a In the formula T_nThe time-varying value of the tested area; t is₀Is the initial value of the tested area.

△L*＝T_n-T₀(ii) a In the formula T_nThe time-varying value of the tested area; t is₀Is the initial value of the tested area.

△ITA°＝T_n-T₀(ii) a In the formula T_nThe time-varying value of the tested area; t is₀Is the initial value of the tested area.

An experimental instrument: multifunctional skin test system (MPA580, CK, germany); skin color difference test probe (CL400, CK, germany); skin red melanin tester and test probe (Mexameter MX18, CK, germany).

The experimental method comprises the following steps: 70 volunteers of 25-45 years old are selected, and the skin is mixed type skin, wherein 28 volunteers are male and 42 volunteers are female. The test subjects were respectively applied to the face twice a day, and 2mg of the product was used in the morning and evening, and the application was continued for 4 weeks, and the skin of the face was subjected to the analysis of melanin and color difference data collection before sampling, and the data was used as the background value of the skin. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site. Data acquisition was performed at week 4. The changes of skin whiteness (brightness) and skin melanin content of the subjects before and after the application of the cosmetics are evaluated, so that the whitening and skin-brightening effects of the product are determined. The results are shown in tables 1,2 and 3 (all data are presented as mean values).

TABLE 1

TABLE 2

TABLE 3

From the data results of tables 1-3, it can be seen that: compared with comparative application examples 1 to 7, the products of application examples 1 to 7 have better whitening and skin brightening effects, and the whitening and skin brightening essence has remarkable whitening and skin brightening effects, wherein the effects of application example 6 and application example 7 are optimal, and the effect of application example 2 is slightly poorer than that of other application examples. Data analysis of application example 1 and comparative application example 7 shows that the whitening and skin-lightening effect of the polyol composition according to the present invention is significantly improved compared to the effect of the polyol composition without the addition of the polyol composition, which indicates that the polyol composition according to the present invention can effectively promote penetration and absorption of whitening actives.

Test example 3

The volunteers in test example 2 simultaneously evaluated the whitening and skin-lightening essence of application examples 1 to 7 and comparative application examples 1 to 7 in several dimensions of smell, texture in appearance, feeling of smearing, absorbency, stickiness, moisture retention and skin softness, and the rating standards and grades were as follows:

the results are shown in table 4 (all data are presented as mean):

TABLE 4

From the data in table 4, it can be seen that: compared with the comparative application examples 1-7, the products of the application examples 1-7 have better evaluation on the indexes of smell, appearance texture, smearing feeling, absorbability, stickiness, moisture retention and skin softness, and the polyol composition disclosed by the invention is added into the whitening and skin-brightening skin-care matrix, so that the problem of transdermal absorption of functional components is improved, the efficacy of the products is improved, and the absorbability, the moisture retention and the smearing feeling and the stickiness of the products are improved. The effects of application example 6 and application example 7 are the best, and the effect of application example 2 is slightly worse than that of other application examples.

Application example 8

The application example provides a moisturizing and skin-care essence which comprises, by mass, 70% of the polyol composition prepared in example 1, 3% of sodium alginate, 0.5% of squalane, 0.5% of sodium hyaluronate, and the balance of deionized water to 100%.

The preparation method comprises the following steps:

(3) and finally, adding the sodium alginate, squalane and sodium hyaluronate, recovering to 25 ℃, and discharging after the inspection is qualified.

Application examples 9 to 14

The present application example provides six moisturizing and skin-care essences whose ingredients differ from application example 8 only in that the polyol composition prepared in example 1 was replaced with the polyol compositions prepared in examples 2 to 7, and the others were all kept unchanged. The preparation method is the same as in application example 8.

Comparative application examples 8 to 13

The present comparative application example provides six moisturizing skin care essences, the components of which are different from those of application example 8 only in that the polyol composition prepared in example 1 is replaced with the polyol compositions prepared in comparative examples 1 to 6, and the others are kept unchanged. The preparation method is the same as in application example 8.

Comparative application example 14

The comparative application example provides a moisturizing and skin-care essence which is different from the application example 8 only in that the polyol composition prepared in example 1 is not contained, and the rest of the essence is kept unchanged.

Test example 3

The water replenishing and moisturizing skin care essence of the application examples 8-14 and the comparative application examples 8-14 was subjected to a safety test:

The result of the human body skin patch test shows that: adverse reactions to skin appear in 0 cases, which shows that the water-replenishing, moisture-preserving and skin-care essence disclosed by the invention is safe and non-irritant to skin.

Test example 4

And carrying out moisturizing and moisturizing efficacy tests on the moisturizing and moisturizing essence of the application examples 8-14 and the comparative application examples 8-14:

the experimental principle is as follows: based on the fact that the dielectric constant of water and other substances changes greatly, according to the difference of water content, a measuring capacitor with a proper shape changes along with the change of capacitance of the skin, and the moisture content of the skin can be measured when the capacitance of the skin is in a measuring range.

An experimental instrument: the test instrument is Corneometer (CK) and is used for measuring the moisture content of the skin; before each test, the skin is cleaned by water, and the test is carried out after the skin is dried after 30 min;

the experimental method comprises the following steps: the 4 areas of the test, each 1X 1cm in size, were marked on the face of the subject using a template prepared beforehand²The other half face was used as a blank control area, and samples were applied to all test areas at a rate of 2mg/cm². Before the basic value test, the skin is cleaned by water, the skin is dried after 30min, and then the measurement is carried out, and the measurement is carried out for 1h, 2h and 4h after the sample is used;

the temperature is controlled at 22 +/-2 ℃ and the relative humidity is 50 +/-5% during the test process.

The results are shown in table 5 (all data are presented as mean values).

TABLE 5

From the data in table 5, it can be seen that: compared with comparative application examples 8-14, the products of application examples 8-14 have more remarkable moisturizing and moisturizing effects, and the polyol composition disclosed by the invention is added into a moisturizing and moisturizing skin care substrate, so that the penetration and absorption of moisturizing and moisturizing effect components can be effectively promoted, and the efficacy of the product is improved. The application 13 and the application 14 have the best effect, and the application 9 has a slightly worse effect compared with other applications.

The applicant states that the present invention is illustrated by the above examples of a polyol composition and its use in cosmetics, but the present invention is not limited to the above examples, i.e. it is not meant to imply that the present invention must be practiced in reliance thereon. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.

It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

Claims

1. A polyol composition, characterized in that said polyol composition comprises: panthenol, 1, 2-propanediol, 1, 3-propanediol, and polyethylene glycol.

2. The polyol composition of claim 1 wherein the mass ratio of panthenol, 1, 2-propanediol, 1, 3-propanediol, and polyethylene glycol is (1-8): (5-20);

preferably, the mass ratio of the panthenol, the 1, 2-propylene glycol, the 1, 3-propylene glycol and the polyethylene glycol is (1-5): 10-20.

3. The polyol composition of claim 1 or 2 further comprising any one or a combination of at least two of glycerol, butanediol, or 1, 2-hexanediol; a combination of glycerol, butylene glycol and 1, 2-hexanediol is preferred.

4. The polyol composition of claim 3 wherein the mass ratio of glycerol to panthenol is (5-13): (1-8), preferably (5-10): (1-5);

5. The polyol composition of any of claims 1 to 4, wherein said polyol composition further comprises dipropylene glycol and/or pentanediol, preferably a combination of dipropylene glycol and pentanediol.

6. Use of the polyol composition according to any of claims 1 to 5 for the preparation of a cosmetic product.

7. Use according to claim 6, wherein the polyol composition is added to the cosmetic in an amount of 30-90%, preferably 40-80%, further preferably 50-80%.

8. The whitening and skin-brightening skin care product is characterized by comprising the following preparation raw materials in percentage by mass: the polyol composition of any of claims 1-5 from 50-80%, a whitening skin lightening base from 0.1-10%, water;

9. The moisturizing skin care product is characterized by comprising the following preparation raw materials in percentage by mass: the polyol composition of any of claims 1-5, from 50-80%, the moisturizing base from 0.05-10%, water;

10. The skin-tightening skin care product is characterized by comprising the following raw materials in percentage by mass: the polyol composition of any of claims 1-5, from 50-80%, firm skin substrate 0.05-10%, water;