Biochip washing and drying instrument convenient to use
Technical Field
The invention relates to the technical field of biochip washing and drying instruments, in particular to a biochip washing and drying instrument convenient to use.
Background
A biological gene chip is also called as biological chip, the biological chip is that a large number of probe molecules are fixed on a support and then hybridized with marked sample molecules, the quantity and sequence information of the sample molecules are obtained by detecting the hybridization signal intensity of each probe molecule, in a popular way, DNA fragments (gene probes) with specific sequences are regularly arranged and fixed on the supports such as a silicon chip, a glass slide and the like with the length of 2 square centimeters by a micromachining technology, and a biological chip washing and drying instrument is used for washing and drying a microarray chip after affinity binding reaction and can automatically wash and centrifugally dry the chip.
The biochip washing and drying instrument used in the market has a problem which needs to be solved urgently, when the biochip washing and drying instrument is used for washing biochips, the biochips to be washed are often manually placed on a placing rack in the biochip washing and drying instrument one by one, the automation degree is very low, the risk of repeated pollution of the biochips is increased, and the biochip washing and drying instrument is very troublesome and is not convenient to use.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the convenient-to-use biochip washing and drying instrument, and solves the problems that when the biochip washing and drying instrument is used for washing biochips, the biochips are very troublesome to place, and are easy to cause redundant pollution, so that the washing is laborious.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a biochip washing and drying instrument convenient to use comprises a shell, wherein a middle plate is arranged in the middle of the inside of the shell, a cleaning cavity is arranged on one side of the inside of the shell, a first mounting cavity is arranged on the upper portion of the other side of the inside of the shell, a second mounting cavity is arranged on the lower portion of the other side of the inside of the shell, the rear end of the cleaning cavity is rotatably connected with a cover body through a hinge, a rotary disc is rotatably connected to the bottom of the cleaning cavity, a second belt wheel is fixedly connected to the middle of the bottom end of the rotary disc, four placing frames are uniformly distributed in the upper end of the rotary disc, the placing frames are hollow, rubber pads are arranged on the inner bottom wall of the placing frames, fixing grooves are uniformly distributed in the top of the placing frames, first rotary shafts are rotatably arranged on two sides of the fixing grooves, cylindrical rubber is uniformly distributed on the periphery of the middle portions of the first rotary shafts, and a second electric slide rail is arranged in the middle of the bottom wall of the first mounting cavity, the upper end of the mounting seat of the second electric sliding rail is fixedly connected with a second sliding seat, one side of the second sliding seat is fixedly connected with one side of the lower end of the first mounting plate, the middle parts of the two sides of the first mounting plate are respectively connected with the middle part of the second rotating shaft through a torsional spring in a rotating manner, one end of the second rotating shaft is respectively fixedly connected with a second rocker, the other end of the second rocker is respectively fixedly connected with a bolt, the second rocker is respectively vertical to the second rotating shaft, the other end of the second rotating shaft is respectively fixedly connected with a second wire roller, the periphery of the second wire roller is respectively wound with a rope, the middle part of the top wall of the first mounting cavity is provided with a first electric sliding rail, the upper end of the mounting seat of the first electric sliding rail is fixedly connected with the lower end of the first sliding seat, the upper end of the first sliding seat is fixedly connected with one side of the bottom end of the mounting block, and the inside of the mounting block is provided with a placing groove, the bottom is provided with the through-hole in the standing groove, the internal diameter more than or equal to the external diameter of chip body of through-hole, be provided with the chip body in the standing groove, one side in the standing groove is provided with the spout, opposite side in the standing groove is provided with electric telescopic handle, the inside slip of spout is provided with the slider, slider fixed connection is in the one end of cross axle, the other end fixed connection of cross axle is at one side middle part of second mounting panel, the equal fixedly connected with vacuum chuck in middle part both sides of second mounting panel opposite side, the vacuum chuck material is silica gel, the left drive end of electric telescopic handle is provided with pressure sensor, pressure sensor's left side fixed connection is at the right side middle part of kicking block, the right side is provided with the controller in the mounting block.
Preferably, the middle part of the upper end in the middle plate is provided with a through groove, the middle part in the through groove is provided with a through plate in a sliding manner, the middle part of the bottom end of the through plate is fixedly connected to the driving end of the upper end of the electric push rod, and the electric push rod is arranged at the middle lower part in the middle plate.
Preferably, a first servo motor is fixedly connected to one side of the top of the second mounting cavity, a first belt wheel is fixedly connected to the driving end of the bottom end of the first servo motor, and the first belt wheel is connected with a second belt wheel through a belt.
Preferably, the thickness of cylinder rubber all equals the width of fixed slot, the one end of first pivot all runs through one side lateral wall of rack and the equal fixed connection of first pivot in the upper end of first rocker, the lower extreme of first rocker all is provided with the jack, the internal diameter more than or equal to the external diameter of bolt of jack, the rack is provided with the recess in first rocker one side lateral wall upper end middle part, the interior middle part of recess rotates through the round pin axle and is connected with the triangle fixture block, upper portion fixedly connected with spring in the recess, the other end fixed connection of spring is in one side of triangle fixture block.
Preferably, the one end that the second line roller was kept away from to the rope all convolutes in the periphery of first line roller, first line roller rotates through the third pivot and connects the well upper portion of keeping away from second rocker one side at first mounting panel, the one end fixedly connected with second bevel gear that first mounting panel was kept away from to the third pivot, second bevel gear meshing is connected with first bevel gear, first bevel gear fixed connection is at the drive end of third servo motor upper end, third servo motor fixed connection is in one side of second sliding seat upper end.
Preferably, the middle part of the transverse shaft is in threaded connection with the periphery of the screw rod through a threaded sleeve, the bottom end of the screw rod is fixedly connected with the driving end at the upper end of the second servo motor, and the second servo motor is fixedly connected to one side of the bottom in the placing groove.
Preferably, the interior middle part of second mounting panel is provided with the pipeline, the pipeline all communicates with vacuum chuck, the one end fixed connection that the second mounting panel was kept away from to the pipeline is in micro vacuum pump's upper end, micro vacuum pump sets up inside the installation piece right side.
Preferably, the electric telescopic rod, the micro vacuum pump and the second servo motor are electrically connected with the controller.
The working principle is as follows: when the convenient-to-use biological chip washing and drying instrument is used, the cover body of the chip washing and drying instrument is opened, the first sliding seat slides on the first electric slide rail to enable the installation block to move leftwards, the first servo motor enables the rotary table to drive the placing frame to rotate through the first belt wheel and the second belt wheel, after the movement is finished, the through hole at the bottom of the placing groove is enabled to be right opposite to the fixing groove at the top of the placing frame, meanwhile, the jack at one side of the placing frame is right opposite to the through groove, the jack is right opposite to the bolt in the first installation cavity, then, the chip body to be cleaned is placed into the placing groove, the electric telescopic rod is started to push the chip body in the placing groove to enable the chip body to be close to the vacuum chuck on the second installation plate, then the micro vacuum pump enables the vacuum chuck to suck the chip body through a pipeline, the second servo motor works to enable the screw rod to rotate, and the transverse shaft drives the second installation plate to enable the vacuum chuck to suck the chip body downwards, the chip bodies enter the through holes downwards, then the micro vacuum pump stops working, the chip bodies fall from the vacuum suckers, then the chip bodies fall into the fixing grooves, after the former chip bodies fall into the fixing grooves in the placing rack, the first electric slide rail drives the first sliding seat to move rightwards, the through holes are opposite to the next fixing groove, the electric telescopic rod can push the chip bodies to be close to the vacuum suckers within a certain pressure range through the arrangement of the pressure sensor, the next chip body 4 is adsorbed by the vacuum suckers after one chip body falls into the fixing groove, then the electric push rod enables the through plate to move downwards in the through groove, the operation is repeated repeatedly until the chip bodies all enter the fixing groove, then the second electric slide rail drives the second sliding seat to move leftwards, the bolt is inserted into the through hole, and the third servo motor drives the third rotating shaft through the first bevel gear and the second bevel gear, the third pivot makes first line roller rotate, first line roller makes the second pivot rotate through rope pulling second line roller, the second pivot makes the second rocker stir the bolt to the inboard, the first rocker is stirred through the jack to the bolt, first rocker rotates to the inboard and makes first pivot drive cylinder rubber and rotate, cylinder rubber rotates to the inboard and extrudees the chip body and makes the chip body fix in the rack, first rocker is spacing fixed by the triangle fixture block simultaneously, realize that the chip body is fixed by cylinder rubber, after fixing the chip body, first electronic slide rail makes the installation piece move to the right, second electronic slide rail makes the second sliding seat move to the right, electric putter makes the logical sealed logical groove of logical board, close down the chip of lid and wash the appearance and wash the chip body in the rack, be worth wideling popularize.
(III) advantageous effects
The invention provides a biochip washing and drying instrument convenient to use. The method has the following beneficial effects:
according to the chip washing and drying device, after the chip bodies are placed in the placing groove, the chip bodies can be automatically dropped into the fixing groove in the placing frame through the cooperation of the vacuum chuck and the jacking block, meanwhile, the chip bodies in the fixing groove can be automatically fixed by the cylindrical rubber after being placed, the chip bodies are placed in the placing frame without workers, the workload of the workers is relieved, the automation degree of the chip washing and drying device is improved, meanwhile, the chip bodies cannot be touched for multiple times when being placed, the risk of repeated pollution of the chips is reduced, the chips are convenient to wash, the chip washing and drying device is convenient to use, and the chip washing and drying device is worthy of being widely popularized.
Drawings
FIG. 1 is a perspective view of the present invention;
FIG. 2 is a schematic structural view of the present invention;
figure 3 is a perspective view of the rack of the present invention;
FIG. 4 is a side view of the triangular fixture block of the present invention;
FIG. 5 is a side view of the cylindrical rubber of the present invention;
FIG. 6 is a left side view of the first mounting plate of the present invention;
FIG. 7 is a right side view of the first mounting plate of the present invention;
FIG. 8 is an enlarged view taken at A in FIG. 2;
fig. 9 is an enlarged view of fig. 2 at B.
Wherein, 1, a shell; 2. a cleaning chamber; 3. a cover body; 4. a chip body; 5. mounting blocks; 6. a pipeline; 7. a first sliding seat; 8. a through groove; 9. a top block; 10. a pressure sensor; 11. a placement groove; 12. a controller; 13. an electric telescopic rod; 14. a micro vacuum pump; 15. passing through a plate; 16. a first electric slide rail; 17. a first mounting cavity; 18. a second electric slide rail; 19. a second mounting cavity; 20. a first servo motor; 21. a first pulley; 22. an electric push rod; 23. a middle plate; 24. placing a rack; 25. a second pulley; 26. a turntable; 27. a rubber pad; 28. a jack; 29. a first rocker; 30. fixing grooves; 31. a triangular clamping block; 32. a pin shaft; 33. a groove; 34. a spring; 35. cylindrical rubber; 36. a first rotating shaft; 37. a second rotating shaft; 38. a second rocker; 39. a bolt; 40. a first mounting plate; 41. a rope; 42. a first wire roll; 43. a second servo motor; 44. a screw; 45. a horizontal axis; 46. a slider; 47. a chute; 48. a vacuum chuck; 49. a second mounting plate; 50. a second wire roller; 51. a third servo motor; 52. a first bevel gear; 53. a second bevel gear; 54. a third rotating shaft; 55. a second sliding seat; 56. a torsion spring; 57. and a through hole.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example (b):
as shown in FIGS. 1-9, the embodiment of the invention provides a convenient biochip washing and drying apparatus, which comprises a casing 1, wherein a middle plate 23 is arranged in the middle of the inside of the casing 1, a washing cavity 2 is arranged on one side of the inside of the casing 1, a first installation cavity 17 is arranged on the upper portion of the other side of the inside of the casing 1, a second installation cavity 19 is arranged on the lower portion of the other side of the inside of the casing 1, a cover body 3 is rotatably connected to the rear end of the washing cavity 2 through a hinge, after a chip body 4 is fixed, a first electric slide rail 16 enables an installation block 5 to move rightwards, a second electric slide rail 18 enables a second slide seat 55 to move rightwards, an electric push rod 22 enables a through plate 15 to seal a through groove 8, the chip washing and drying apparatus closes the cover body 3 to wash the chip body 4 in a placing frame 24, a rotating disc 26 is rotatably connected to the bottom of the washing cavity 2, a second belt wheel 25 is fixedly connected to the middle of the bottom end of the rotating disc 26, and four placing frames 24 are uniformly distributed in the upper end of the rotating disc 26, the placing rack 24 is hollow, a rubber pad 27 is arranged on the inner bottom wall of the placing rack 24, fixing grooves 30 are uniformly distributed on the inner top of the placing rack 24, first rotating shafts 36 are rotatably arranged on two sides of each fixing groove 30, cylindrical rubber 35 is uniformly distributed on the peripheries of the middle portions of the first rotating shafts 36, a second electric slide rail 18 is arranged on the middle portion of the inner bottom wall of the first mounting cavity 17, a second sliding seat 55 is fixedly connected to the upper end of a mounting seat of the second electric slide rail 18, one side of the second sliding seat 55 is fixedly connected to one side of the lower end of the first mounting plate 40, the middle portions of two sides of the first mounting plate 40 are rotatably connected to the middle portion of the second rotating shaft 37 through a torsion spring 56, a second rocker 38 is fixedly connected to one end of the second rotating shaft 37, a bolt 39 is fixedly connected to the other end of the second rocker 38, the bolt 39 is just opposite to the bolt 39 in the first mounting cavity 17, so that the bolt 39 can directly enter the inserting hole 28 when the second sliding seat 55 moves, the second rocking bars 38 are all vertical to the second rotating shaft 37, the other end of the second rotating shaft 37 is fixedly connected with a second wire roller 50, the periphery of the second wire roller 50 is wound with a rope 41, the middle part of the top wall of the first installation cavity 17 is provided with a first electric slide rail 16, the upper end of an installation seat of the first electric slide rail 16 is fixedly connected with the lower end of a first slide seat 7, the first slide seat 7 slides on the first electric slide rail 16 to enable the installation block 5 to move leftwards, the first electric slide rail 16 mainly moves relative to the position of the placing frame 24, after a chip body 4 is placed in a fixed groove 30 on the placing frame 24, the first electric slide rail 16 drives the first slide seat 7 to enable the installation block 5 to move, so that the through hole 57 can be over against the next fixed groove 30, the chip body 4 can well fall down, the upper end of the first slide seat 7 is fixedly connected with one side of the bottom end of the installation block 5, a placing groove 11 is arranged in the installation block 5, the bottom of the placing groove 11 is provided with a through hole 57, the first servo motor 20 enables the rotary table 26 to drive the placing frame 24 to rotate through the first belt wheel 21 and the second belt wheel 25, after the movement, the through hole 57 at the bottom of the placing groove 11 is just opposite to the fixing groove 30 at the top of the placing frame 24, meanwhile, the jack 28 at one side of the placing frame 24 is just opposite to the through groove 8, the first servo motor 20 enables the fixing groove 30 on the placing frame 24 to be just right under the through hole 57 through the rotation of the rotary table 26, simultaneously, after the chip body 4 is placed into the previous fixing groove 30, the first electric slide rail 16 drives the mounting block 5 to move rightwards, the through hole 57 is just opposite to the next fixing groove 30, the chip body 4 can well fall down when falling, the inner diameter of the through hole 57 is more than or equal to the outer diameter of the chip body 4, the chip body 4 is arranged in the placing groove 11, one side in the placing groove 11 is provided with a sliding groove 47, the other side in the placing groove 11 is provided with an electric telescopic rod 13, a sliding block 46 is arranged inside the sliding groove 47 in a sliding manner, the sliding block 46 is fixedly connected to one end of a transverse shaft 45, the other end of the transverse shaft 45 is fixedly connected to the middle of one side of a second mounting plate 49, vacuum suckers 48 are fixedly connected to two sides of the middle of the other side of the second mounting plate 49, the vacuum suckers 48 are made of silica gel, a pressure sensor 10 is arranged at the left driving end of an electric telescopic rod 13, the left side of the pressure sensor 10 is fixedly connected to the middle of the right side of a top block 9, a controller 12 is arranged at the right side in a mounting block 5, a chip body 4 to be cleaned is placed in a placing groove 11, the electric telescopic rod 13 is started, the electric telescopic rod 13 pushes the chip body 4 in the placing groove 11 to enable the chip body 4 to be close to the vacuum suckers 48 on the second mounting plate 49, then a micro vacuum pump 14 enables the vacuum suckers 48 to suck the chip body 4 through a pipeline 6, and a second servo motor 43 works to enable a screw 44 to rotate, the lateral shaft 45 drives the second mounting plate 49 to make the vacuum chuck 48 suck the chip body 4 to move downward, the chip body 4 enters the through hole 57 downward, then the micro vacuum pump 14 stops working, the chip body 4 falls from the vacuum chuck 48, and then the chip body 4 falls into the fixing groove 30.
The upper end middle part in the intermediate lamella 23 is provided with logical groove 8, the middle part slides in leading to groove 8 and is provided with logical board 15, the bottom middle part fixed connection that leads to board 15 is at the drive end of electric putter 22 upper end, electric putter 22 sets up the well lower part in intermediate lamella 23, when the appearance work is washed to the chip, wash the inside in chamber 2 and be can not permeable to water, so can stir by bolt 39 when leading to groove 8 above the intermediate lamella 23 can guarantee that chip body 4 fixes on rack 24, also can be after chip body 4 is fixed on rack 24, lead to board 15 is closed logical groove 8 by electric putter 22 drive.
First servo motor 20 of top one side fixedly connected with in the second installation cavity 19, the first band pulley 21 of drive end fixedly connected with in the bottom of first servo motor 20, first band pulley 21 is connected with second band pulley 25 through the belt, it is first when placing chip body 4, first servo motor 20 makes rack 24 rotate to the lower part of installation piece 5 through first band pulley 21 and second band pulley 25 successively, it is just right to realize through-hole 57 and fixed slot 30, first servo motor 20 also is used for driving carousel 26 to rotate when wasing chip body 4, make chip body 4 above the rack 24 can be washd by the inside washing liquid in washing cavity 2.
The thickness of the cylindrical rubber 35 is equal to the width of the fixing groove 30, one end of the first rotating shaft 36 penetrates through the side wall of one side of the placing frame 24, the first rotating shaft 36 is fixedly connected to the upper end of the first rocker 29, the lower end of the first rocker 29 is provided with the jack 28, the inner diameter of the jack 28 is larger than or equal to the outer diameter of the bolt 39, the placing frame 24 is provided with a groove 33 in the middle of the upper end of the side wall of one side of the first rocker 29, the inner middle of the groove 33 is rotatably connected with the triangular clamping block 31 through a pin shaft 32, the upper portion in the groove 33 is fixedly connected with the spring 34, the other end of the spring 34 is fixedly connected to one side of the triangular clamping block 31, the second rotating shaft 37 enables the second rocker 38 to shift the bolt 39 inwards, the bolt 39 shifts the first rocker 29 through the jack 28, the first rocker 29 rotates inwards to enable the first rotating shaft 36 to drive the cylindrical rubber 35 to rotate, the cylindrical rubber 35 rotates inwards to extrude the chip body 4 to enable the chip body 4 to be fixed in the placing frame 24, the first rocker 29 is limited and fixed by the triangular clamping block 31, so that the chip body 4 is fixed by the cylindrical rubber 35.
One end of the rope 41 far away from the second wire roller 50 is wound on the periphery of the first wire roller 42, the first wire roller 42 is rotatably connected to the middle upper part of one side of the first mounting plate 40 far away from the second rocker 38 through a third rotating shaft 54, one end of the third rotating shaft 54 far away from the first mounting plate 40 is fixedly connected with a second bevel gear 53, the second bevel gear 53 is in meshed connection with a first bevel gear 52, the first bevel gear 52 is fixedly connected to the driving end of the upper end of a third servo motor 51, the third servo motor 51 is fixedly connected to one side of the upper end of a second sliding seat 55, the second electric sliding rail 18 drives the second sliding seat 55 to move leftwards, so that the plug pin 39 is inserted into the jack 28, the third servo motor 51 drives the third rotating shaft 54 through the first bevel gear 52 and the second bevel gear 53, the third rotating shaft 54 enables the first wire roller 42 to rotate, and the first wire roller 42 pulls the second wire roller 50 through the rope 41 to enable the second rotating shaft 37 to rotate.
The middle part of the cross shaft 45 is connected to the periphery of the screw rod 44 through a thread sleeve, the bottom end of the screw rod 44 is fixedly connected to the driving end at the upper end of the second servo motor 43, the second servo motor 43 is fixedly connected to one side of the bottom in the placing groove 11, when the vacuum chip mounter is used, the second servo motor 43 drives the screw rod 44 to drive the cross shaft 45 through the screw rod 44, the cross shaft 45 drives the second mounting plate 49 to move downwards, and the purpose that the vacuum chuck 48 drives the chip body 4 to enter the through hole 57 is achieved.
Second mounting panel 49's interior middle part is provided with pipeline 6, pipeline 6 all communicates with vacuum chuck 48, the one end fixed connection that second mounting panel 49 was kept away from to pipeline 6 is in micro vacuum pump 14's upper end, micro vacuum pump 14 sets up inside installation piece 5 right sides, after a preceding chip body 4 fell into the fixed slot 30 in rack 24, first electronic slide rail 16 drives first sliding seat 7 and moves right, it is just right next fixed slot 30 to make through-hole 57, electric telescopic handle 13 can push away chip body 4 and be close to vacuum chuck 48 in certain pressure range through pressure sensor 10's setting, next chip body 4 is adsorbed by vacuum chuck 48 after a chip body 4 fell into fixed slot 30, later electric putter 22 makes logical board 15 remove downwards in leading to groove 8, repeat repeatedly until chip body 4 all gets into fixed slot 30.
The electric telescopic rod 13, the micro vacuum pump 14 and the second servo motor 43 are all electrically connected with the controller 12.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.