CN113080546A - Mask for treating and/or preventing rhinitis and preparation method thereof - Google Patents
Mask for treating and/or preventing rhinitis and preparation method thereof Download PDFInfo
- Publication number
- CN113080546A CN113080546A CN202110345927.9A CN202110345927A CN113080546A CN 113080546 A CN113080546 A CN 113080546A CN 202110345927 A CN202110345927 A CN 202110345927A CN 113080546 A CN113080546 A CN 113080546A
- Authority
- CN
- China
- Prior art keywords
- parts
- mask
- traditional chinese
- chinese medicine
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 44
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Images
Classifications
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- A—HUMAN NECESSITIES
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- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
- A41D13/1107—Protective face masks, e.g. for surgical use, or for use in foul atmospheres characterised by their shape
- A41D13/1115—Protective face masks, e.g. for surgical use, or for use in foul atmospheres characterised by their shape with a horizontal pleated pocket
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D2400/00—Functions or special features of garments
- A41D2400/32—Therapeutic use
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the field of masks, and particularly relates to a mask for treating and/or preventing rhinitis and a preparation method thereof. The mask comprises a mask body and a traditional Chinese medicine insertion piece, wherein the traditional Chinese medicine insertion piece is arranged on the inner side or the outer side of the mask body, and comprises: the traditional Chinese medicine insertion piece comprises, by weight, 5-7 parts of cocklebur fruit, 4-8 parts of biond magnolia flower, 6-10 parts of mint, 5-8 parts of angelica dahurica, 4-8 parts of scutellaria baicalensis, 5-8 parts of gardenia, 4-7 parts of radix bupleuri, 1-3 parts of asarum, 5-7 parts of ligusticum wallichii, 12-16 parts of astragalus membranaceus, 4-7 parts of caulis clematidis armandii, 4-8 parts of platycodon grandiflorum and 7-10 parts of poria cocos. The traditional Chinese medicine insertion piece can effectively treat rhinitis, and when the traditional Chinese medicine insertion piece is arranged on the inner side or the outer side of a mask, liquid medicine emitted by the traditional Chinese medicine insertion piece can enter the nasal cavity of a patient through breathing when a consumer wears the mask, so that the rhinitis can be effectively treated and/or prevented.
Description
Technical Field
The invention belongs to the field of masks, and particularly relates to a mask for treating and/or preventing rhinitis and a preparation method thereof.
Background
The mask is a sanitary article, is generally worn on the mouth and nose for filtering air entering the mouth and nose so as to achieve the effect of blocking harmful gas, smell, spray, virus and other substances, and is made of gauze, paper and other materials. The mask has a certain filtering function on air entering the lung, and has a very good effect when being worn in respiratory infectious diseases and working in environments polluted by dust and the like. The mask may be classified into an air filtering type mask and an air supplying type mask.
The existing common mask sewn by multiple layers of gauze is mainly used in hospitals or air polluted environments to prevent disease transmission, has a certain curative effect, prevents part of virus and germs directly exhaled by patients from entering human bodies, and reduces the occurrence of respiratory infectious diseases.
However, the existing common mask only has the function of filtering air, so that the existing common mask is difficult to effectively treat and/or prevent rhinitis.
Disclosure of Invention
The invention aims to solve the technical problem that the existing common mask in the background technology is difficult to effectively treat and/or prevent rhinitis due to the fact that the existing common mask only has the function of filtering air, and provides a mask for treating and/or preventing rhinitis.
The technical scheme adopted by the invention is as follows:
the invention provides a mask for treating and/or preventing rhinitis, which comprises a mask body and a traditional Chinese medicine insertion piece, wherein the traditional Chinese medicine insertion piece is arranged on the inner side or the outer side of the mask body, and the traditional Chinese medicine insertion piece comprises the following components in parts by weight:
the traditional Chinese medicine insertion piece comprises, by weight, 5-7 parts of cocklebur fruit, 4-8 parts of biond magnolia flower, 6-10 parts of mint, 5-8 parts of angelica dahurica, 4-8 parts of scutellaria baicalensis, 5-8 parts of gardenia, 4-7 parts of radix bupleuri, 1-3 parts of asarum, 5-7 parts of ligusticum wallichii, 12-16 parts of astragalus membranaceus, 4-7 parts of caulis clematidis armandii, 4-8 parts of platycodon grandiflorum and 7-10 parts of poria cocos.
The invention has the beneficial effects that: the traditional Chinese medicine insertion piece can effectively treat rhinitis, and when the traditional Chinese medicine insertion piece is arranged on the inner side or the outer side of a mask, liquid medicine emitted by the traditional Chinese medicine insertion piece can enter the nasal cavity of a patient through breathing when a consumer wears the mask. Thereby effectively treating and/or preventing rhinitis. Solves the technical problem that the existing common mask is difficult to effectively treat and/or prevent rhinitis due to the function of filtering air.
On the basis of the technical scheme, the invention can be further improved as follows.
Further, the traditional Chinese medicine insertion piece comprises 5.5-6.5 parts by weight of cocklebur fruit, 5-6 parts by weight of biond magnolia flower, 8-9 parts by weight of mint, 6-7 parts by weight of angelica dahurica, 5-6 parts by weight of scutellaria baicalensis, 6-7 parts by weight of gardenia, 5.5-6 parts by weight of radix bupleuri, 1-2 parts by weight of asarum, 6-7 parts by weight of ligusticum wallichii, 14-15 parts by weight of astragalus mongholicus, 5-6 parts by weight of caulis clematidis armandii, 5-6 parts by weight of platycodon grandiflorum and 8-9 parts by weight of poria.
The further scheme has the beneficial effect that the traditional Chinese medicine insertion piece with the components in the proportion can achieve a better effect of treating rhinitis.
Furthermore, the traditional Chinese medicine insertion piece also comprises a sustained and controlled release matrix.
The mask adopting the further scheme has the beneficial effects that by adding the sustained-release matrix, the diffusion of smell can be delayed, so that the mask can have a more lasting effect of treating or preventing rhinitis.
Further, the sustained and controlled release matrix comprises, by weight, 5-7 parts of peach gum, 5-7 parts of glycerol, 3-5 parts of powdery silica gel, 3-5 parts of sodium polyacrylate, 1-2 parts of activated carbon, 2-3 parts of dihydroxyaluminum glycinate and 1-2 parts of titanium dioxide. Preferably, the controlled release matrix further comprises 8-10 parts by weight of tragacanth.
The adoption of the further scheme has the beneficial effects that the tragacanth has higher viscosity but poor emulsifying capacity, so that the tragacanth is matched with peach gum for use and is combined with sodium polyacrylate, so that the viscosity of the controlled-release matrix is moderate, the change of the long-term viscosity is extremely small, and the controlled-release matrix is easy to peel and not easy to decay; the glycerin is the most commonly used humectant, can be mutually dissolved with water in any proportion, has good moisturizing effect, is mild and has no irritation; since sodium polyacrylate is linear copolymer, Al is required3+Cross-linking with the aluminum hydroxide, so aluminum hydroxide is selected as a cross-linking agent; powdery silica gel is used as a filling agent; azone is a penetration enhancer and promotes the release of active ingredients of the medicine; the functional particles of active carbon and titanium dioxide are added into the matrix, so that virus particles can be adsorbed and decomposed under the photocatalysis effect, and the active carbon and the titanium dioxide are cooperated with the medicinal materials in the invention, so that the antiviral effect is enhanced. The combination of the traditional Chinese medicine tablet and the corresponding proportion of the 13 nasosinusitis Chinese medicines in the traditional Chinese medicine tablet can ensure that an effective virus filtration barrier is formed, can prolong the time of the antiviral protection action, can ensure that the corresponding indexes of the forming property, the adhesive force and the like meet the quality standard specification, and has moderate softness. The combination of other proportions has bad influence on the quality of the product.
On the other hand, the invention also provides a mask for treating and/or preventing rhinitis, which comprises a mask body, a medicine storage bag and a traditional Chinese medicine insertion piece, wherein:
a medicine storage bag is arranged on the outer side or the inner side of the mask body;
the medicine storage bag is provided with only one opening, and the opening end of the medicine storage bag is provided with a magic tape for opening or closing the opening;
the traditional Chinese medicine insertion pieces can enter and exit the medicine storage bag through the opening of the medicine storage bag.
The mask has the beneficial effects that the traditional Chinese medicine insertion piece is separated from a patient by the medicine storage bag, and the medicine storage bag is arranged on two sides of the mask body. Therefore, the pollution caused by the interference of the traditional Chinese medicine insert is reduced, and the treatment effect of the traditional Chinese medicine insert on the rhinitis of consumers can be improved.
On the basis of the technical scheme, the invention can be further improved as follows.
Further, the medicine storage bag is arranged on the inner side of the mask body.
Adopt above-mentioned further scheme's beneficial effect is, set up the effect that can promote the treatment of traditional chinese medicine inserted sheet or prevent rhinitis in the inboard.
Furthermore, a plurality of vent holes are arranged on the medicine storage bag.
Adopt above-mentioned further scheme's beneficial effect is, the exhaust hole can effectively strengthen the circulation of air between traditional chinese medicine inserted sheet and the user, is favorable to promoting the curative effect.
Furthermore, the medicine storage bag is made of moisture absorption heating fibers.
The beneficial effect who adopts above-mentioned further scheme is that, because the moisture absorption heating fiber who stores up the medicine bag adoption makes, so the user is at the breathing process after wearing the gauze mask, owing to the steam of breathing out for store up the medicine bag and generate heat, thereby let the traditional chinese medicine inserted sheet generate heat, great promotion the drug effect.
On the other hand, the invention also provides a preparation method of the mask for treating and/or preventing rhinitis, which comprises the steps of firstly taking the mask body, sewing the medicine storage bag on the inner side of the mask body, then putting the traditional Chinese medicine insertion piece into the medicine storage bag from the opening of the medicine storage bag, and finally sealing the opening of the medicine storage bag by the magic tape to obtain the mask for treating and/or preventing rhinitis.
The mask has the beneficial effects that the manufacturing process of the mask is convenient and quick, and the technical problem to be solved by the mask can be effectively realized.
On the basis of the technical scheme, the invention can be further improved as follows.
Further, the preparation steps of the traditional Chinese medicine insert are as follows:
s1, adding water into flos Magnoliae, fructus Xanthii, herba Menthae, radix Angelicae Dahuricae, fructus Gardeniae, radix bupleuri, herba asari, rhizoma Chuanxiong, radix astragali, caulis Clematidis Armandii, radix Platycodonis, and Poria at above ratio, distilling at least once, and collecting distillate and residue;
s2, sequentially decocting and concentrating the decoction dregs obtained in the step S1, adding ethanol to enable the alcohol content to reach 67-74 wt%, and concentrating to obtain an alcohol extract;
s3, adding water into the scutellaria baicalensis according to the proportion, decocting and concentrating, and adjusting the pH value to 1.5-2 to obtain scutellaria baicalensis precipitates;
s4, mixing the distillate in the step S1, the alcohol extract in the step S2 and the scutellaria baicalensis precipitate in the step S3 to obtain an extracted liquid medicine;
s5, mixing and stirring peach gum, tragacanth gum and distilled water, and swelling to obtain a first mixture;
s6, mixing and stirring the sodium polyacrylate and the distilled water under the water bath condition to fully swell the sodium polyacrylate and the distilled water to obtain a second mixture;
s7, mixing the first mixture and the second mixture, and heating and stirring the mixture under the condition of water bath until the mixture is completely dissolved to obtain a third mixture;
s8, mixing the powdery silica gel, the activated carbon, the titanium dioxide, the azone and the third mixture, and heating and uniformly stirring the mixture under the water bath condition to obtain a fourth mixture; uniformly dispersing the dihydroxyaluminum glycerolate by using glycerol, and uniformly mixing and stirring the mixture and the fourth mixture to obtain a sustained and controlled release matrix;
s9, uniformly mixing the sustained and controlled release matrix with the extracted liquid medicine obtained in the step S4, heating the mixture in water bath, continuously stirring and refining the mixture to a concentrated solution state, and finally sequentially coating, drying, sticking an anti-sticking film and slicing the lining cloth to obtain the traditional Chinese medicine insert.
The further scheme has the beneficial effect that the traditional Chinese medicine inserting piece can be well manufactured through the preparation steps. The surface of the traditional Chinese medicine insert is coated with a slow controlled release matrix and the extracted liquid medicine which are obtained by mixing and dissolving in a concentrated way, so that the components of the extracted liquid medicine can slowly volatilize and enter the nasal cavity of a user, thereby achieving the effect of treating or preventing rhinitis.
Drawings
Fig. 1 is a front view of the mask of the present invention;
fig. 2 is a side view of the mask of the present invention;
fig. 3 is a rear view of the mask of the present invention;
FIG. 4 is an exploded view of FIG. 3 of the present invention;
FIG. 5 is a line drawing of the present invention;
in the drawings, the components represented by the respective reference numerals are listed below:
1. mask body, 2, medicine storage bag, 201, exhaust hole, 202, magic subsides, 3, traditional chinese medicine inserted sheet
Detailed Description
The principles and features of this invention are described below in conjunction with the following drawings, which are set forth by way of illustration only and are not intended to limit the scope of the invention.
Examples 1,
As shown in fig. 1 to 4, a method for preparing a mask for treating and/or preventing rhinitis comprises the steps of firstly taking a mask body 1, sewing a medicine storage bag 2 at the inner side of the mask body 1, then putting a traditional Chinese medicine insertion piece 3 into the medicine storage bag 2 from an opening of the medicine storage bag 2, and finally sealing the opening of the medicine storage bag 2 by a magic tape 202 to obtain the mask for treating and/or preventing rhinitis. Wherein:
the preparation steps of the traditional Chinese medicine insertion piece 3 are as follows:
s1, adding water into 500g of biond magnolia flower, 400g of cocklebur fruit, 600g of mint, 500g of dahurian angelica root, 500g of cape jasmine fruit, 400g of Chinese thorowax root, 100g of asarum, 500g of szechuan lovage rhizome, 1200g of astragalus root, 400g of clematis stem, 400g of platycodon root and 700g of Indian buead according to the mixture ratio for at least one distillation, and collecting distillate and dregs of a decoction;
s2, sequentially decocting and concentrating the decoction dregs obtained in the step S1, adding ethanol to enable the alcohol content to reach 67-74 wt%, and concentrating to obtain an alcohol extract;
s3, adding water into 400g of scutellaria baicalensis according to the proportion, decocting and concentrating, and adjusting the pH value to 1.5-2 to obtain scutellaria baicalensis precipitates;
s4, mixing the distillate in the step S1, the alcohol extract in the step S2 and the scutellaria baicalensis precipitate in the step S3 to obtain an extracted liquid medicine;
s5, mixing 500g of peach gum, 800g of tragacanth and distilled water, stirring for 2min, and swelling to obtain a first mixture; wherein the volume of the added distilled water is 20 times of the total volume of the peach gum and the tragacanth gum;
s6, mixing and stirring 300g of sodium polyacrylate and distilled water under the water bath condition to fully swell the sodium polyacrylate and the distilled water to obtain a second mixture; wherein the volume of the added distilled water is 10 times of that of the sodium polyacrylate;
s7, mixing the first mixture and the second mixture, heating and stirring the mixture under the condition of water bath at 40 ℃ until the mixture is completely dissolved, wherein the stirring speed is 10r/min, and the stirring time is 2min, so as to obtain a third mixture;
s8, mixing 300g of powdery silica gel, 100g of activated carbon, 100g of titanium dioxide, 200g of azone and the third mixture, and heating and uniformly stirring the mixture in a water bath at 50 ℃ to obtain a fourth mixture; uniformly dispersing 200g of dihydroxyaluminum glycinate by using 500g of glycerol, and uniformly mixing and stirring the mixture and the fourth mixture to obtain a sustained and controlled release matrix;
s9, uniformly mixing the sustained and controlled release matrix with the extracted liquid medicine obtained in the step S4, heating the mixture in a water bath condition, continuously stirring and refining the mixture to a concentrated solution state, and finally sequentially coating the mixture on a lining cloth at 45 ℃, drying the mixture in vacuum at 35 ℃ for 3 hours, adhering a polypropylene anti-sticking film and slicing the mixture into 14X10cm2To obtain the traditional Chinese medicine inserting piece 3.
Examples 2,
The differences from example 1 are that 700g of cocklebur fruit, 400g of biond magnolia flower, 600g of mint, 500g of angelica dahurica, 500g of gardenia, 400g of bupleurum, 300g of asarum, 700g of ligusticum wallichii, 1600g of astragalus mongholicus, 700g of clematis stem, 800g of platycodon grandiflorum, 1000g of poria cocos, 800g of scutellaria baicalensis, 700g of peach gum, 1000g of tragacanth, 500g of sodium polyacrylate, 500g of powdered silica gel, 200g of activated carbon, 200g of titanium dioxide, 300g of azone, 700g of glycerol and 300g of dihydroxyaluminium hydroxide.
Examples 3,
The differences from example 1 are that 550g of cocklebur fruit, 500g of biond magnolia flower, 800g of mint, 600g of angelica dahurica, 600g of gardenia, 550g of bupleurum, 100g of asarum, 600g of ligusticum wallichii, 1400g of astragalus mongholicus, 500g of clematis stem, 500g of platycodon grandiflorum, 800g of poria cocos, 500g of scutellaria baicalensis, 600g of peach gum, 850g of tragacanth, 400g of sodium polyacrylate, 320g of powdered silica gel, 130g of activated carbon, 150g of titanium dioxide, 240g of azone, 600g of glycerol and 260g of dihydroxyaluminium.
Examples 4,
The differences from the embodiment 1 are that 650g of cocklebur fruit, 600g of biond magnolia flower, 900g of mint, 700g of angelica dahurica, 700g of cape jasmine, 600g of bupleurum, 200g of asarum, 700g of ligusticum wallichii, 1500g of astragalus mongholicus, 600g of caulis clematidis armandii, 600g of platycodon grandiflorum, 900g of poria cocos, 600g of scutellaria baicalensis, 600g of peach gum, 850g of tragacanth, 400g of sodium polyacrylate, 320g of powdered silica gel, 130g of activated carbon, 150g of titanium dioxide, 240g of azone, 600g of glycerol and 260g of dihydroxyaluminium glycinate.
Examples 5,
The differences from the embodiment 1 are that 600g of cocklebur fruit, 550g of biond magnolia flower, 850g of mint, 650g of angelica dahurica, 650g of cape jasmine, 580g of bupleurum, 150g of asarum, 650g of ligusticum wallichii, 1450g of astragalus mongholicus, 550g of clematis stem, 550g of platycodon grandiflorum, 850g of poria cocos, 550g of scutellaria baicalensis, 600g of peach gum, 850g of tragacanth, 400g of sodium polyacrylate, 320g of powdered silica gel, 130g of activated carbon, 150g of titanium dioxide, 240g of azone, 600g of glycerol and 260g of dihydroxyaluminium.
The difference from example 1 is that peach gum is not included.
The difference from example 1 is that 400g of peach gum is used.
The difference from example 1 is that 800g of peach gum is used.
First, verification experiment
In order to illustrate the technical effects of the invention, the following verification experiments are specially carried out:
1. test for formability
According to the test method of Chinese pharmacopoeia, the traditional Chinese medicine insert 3 according to the embodiments 1-5 and the comparative examples 1-3 is placed in a constant temperature and humidity box with the temperature of 37 ℃ and the relative humidity of 64% for 30min, the sample is taken out and fixed on a flat steel plate, the oblique angle between the steel plate and the horizontal plane is 60 degrees, the sample is placed for 24h, and whether the body surface of the traditional Chinese medicine insert 3 has the flowing phenomenon or not is observed, and the sample is qualified. Specific observations are given in table 1 below:
TABLE 1
As can be seen from Table 1, the traditional Chinese medicine insert 3 of the invention has good forming property, and is beneficial to improving the quality of the mask of the invention.
2. Measurement of adhesion
The masks for treating and/or preventing rhinitis obtained in examples 1-5 and comparative examples 1-3 are lightly pressed to compact the traditional Chinese medicine insertion pieces for 3 min, and then peeled off at 180 degrees, and whether the surface of the mask has paste residues or not is observed. The specific test results are shown in table 2 below:
TABLE 2
As can be seen from table 2, the mask of the present invention has good paste residue. Can reduce the medicine crossing when changing the traditional chinese medicine inserted sheet 3 to promote the drug effect.
3. Determination of Release Rate
Taking the traditional Chinese medicine insertion pieces 3 obtained in the examples 1 to 5 and the comparative examples 1 to 3 respectively, taking baicalin as an index, carrying out content measurement by adopting a high performance liquid method, selecting a vertical improved Franz diffusion cell, taking non-woven fabric as a release membrane, sampling every 2 hours within 24 hours, carrying out content measurement on index components, and calculating the cumulative release rate Q (%) according to the following formula: q (%) ═ Qt/W×100％(Qt: the cumulative release amount per unit area of the index components in the time t; w: the contents of the respective index components in the preparation), a Q-t curve was plotted with time as the abscissa and the cumulative release rate as the ordinate, and the results are shown in fig. 5. Specific data are shown in Table 3 below
TABLE 3
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| 5min | 9％ | 10％ | 6％ | 8％ | 9％ | 18％ | 14％ | 15％ |
| 10min | 23％ | 22％ | 18％ | 22％ | 22％ | 35％ | 30％ | 29％ |
| 15min | 38％ | 39％ | 31％ | 37％ | 38％ | 45％ | 40％ | 41％ |
| 20min | 46％ | 47％ | 40％ | 44％ | 45％ | 56％ | 50％ | 51％ |
| 25min | 50％ | 51％ | 46％ | 48％ | 49％ | 64％ | 55％ | 54％ |
| 30min | 60％ | 63％ | 55％ | 59％ | 58％ | 70％ | 66％ | 67％ |
| 35min | 68％ | 70％ | 61％ | 67％ | 66％ | 78％ | 72％ | 71％ |
As shown in the above table 3, the sustained-release matrix of the present invention greatly prolongs the flavor diffusion time of the Chinese medicinal insert, thereby promoting the treatment of rhinitis and improving the treatment efficiency. The best results are obtained in example 3, and the compositions of the present invention exhibit a better release rate in the range of formulation ratios than compositions outside the range of formulation ratios, with unexpected technical results.
4. Test for determining therapeutic effects
4.1 measurement method
192 volunteers of 20-45 years old who had rhinitis symptoms were selected and randomly divided into a control group, a blank group, an example 3 group, an example 4 group, a comparative example 1 group and a comparative example 2 group, and 32 individuals were selected. Wherein:
the control group was given loratadine tablets treatment 1 (10mg) per time, 1 time per day. The treatment is carried out for 2 weeks.
Blank group, without any other treatment, for 2 weeks.
The mask for treating and/or preventing rhinitis prepared in the group of example 3 was applied for 2 weeks at 45 min/time and 2 times/day.
The mask for treating and/or preventing rhinitis prepared in the group of example 4 is used for 2 weeks at a dose of 45 min/day and 2 times/day.
The mask for treating and/or preventing rhinitis prepared in the group of comparative example 1 is used for 2 weeks at 45 min/time and 2 times/day.
The mask for treating and/or preventing rhinitis prepared in the group of comparative example 2 is used for 2 weeks at 45 min/time and 2 times/day.
Comparing the above 6 groups of rhinitis with water-like nasal discharge, sneezing, nasal obstruction, and nasal itching. And carrying out statistics and evaluation according to the therapeutic effect judgment standard.
4.2 therapeutic efficacy criteria
The effect is shown: a large amount of watery rhinorrhea, paroxysmal sneeze, nasal obstruction, rhinocnesmus and other symptoms and signs disappear;
the method has the following advantages: a large amount of watery nasal discharge, paroxysmal sneeze, nasal obstruction and nasal itching are improved;
and (4) invalidation: a large amount of watery nasal discharge, sneezing, nasal obstruction and rhinocnesmus are not relieved.
Statistical analysis was performed using SPSS 22.0 software.
4.3 evaluation of therapeutic Effect
No adverse reaction is seen in the treatment process of the 6 groups. The specific evaluation results are shown in table 4 below:
TABLE 4
As can be seen from the data in table 4, the mask of the present invention can effectively treat or prevent rhinitis, and the difference is statistically significant (P < 0.05). Among them, example 3 has the best therapeutic effect on rhinitis.
In the description herein, the description of the terms "one embodiment," "some embodiments," "specific embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. The utility model provides a gauze mask of treatment and/or prevention rhinitis which characterized in that, includes gauze mask body (1) and traditional chinese medicine inserted sheet (3), be equipped with on the inboard or the outside of gauze mask body (1) traditional chinese medicine inserted sheet (3), wherein:
the traditional Chinese medicine insertion piece (3) comprises, by weight, 5-7 parts of cocklebur fruit, 4-8 parts of biond magnolia flower, 6-10 parts of mint, 5-8 parts of angelica dahurica, 4-8 parts of scutellaria baicalensis, 5-8 parts of gardenia, 4-7 parts of radix bupleuri, 1-3 parts of asarum, 5-7 parts of ligusticum wallichii, 12-16 parts of astragalus membranaceus, 4-7 parts of caulis clematidis armandii, 4-8 parts of platycodon grandiflorum and 7-10 parts of poria cocos.
2. The mask for treating and/or preventing rhinitis according to claim 1, wherein the traditional Chinese medicine insert (3) comprises 5.5-6.5 parts by weight of cocklebur fruit, 5-6 parts by weight of magnolia flower, 8-9 parts by weight of mint, 6-7 parts by weight of angelica dahurica, 5-6 parts by weight of scutellaria baicalensis, 6-7 parts by weight of gardenia, 5.5-6 parts by weight of radix bupleuri, 1-2 parts by weight of asarum, 6-7 parts by weight of ligusticum wallichii, 14-15 parts by weight of astragalus mongholicus, 5-6 parts by weight of clematis armandii, 5-6 parts by weight of platycodon grandiflorum and 8-9 parts by weight of poria cocos.
3. The mask for treating and/or preventing rhinitis according to any one of claims 1 or 2, wherein the traditional Chinese medicine insert (3) further comprises a sustained-release matrix.
4. The mask for treating and/or preventing rhinitis according to claim 3, wherein the sustained-release matrix comprises, by weight, 5 to 7 parts of peach gum, 8 to 10 parts of tragacanth, 5 to 7 parts of glycerin, 3 to 5 parts of powdered silica gel, 3 to 5 parts of sodium polyacrylate, 1 to 2 parts of activated carbon, 2 to 3 parts of aluminum glyceroxide, 1 to 2 parts of titanium dioxide and 2 to 3 parts of azone.
5. The utility model provides a gauze mask of treatment and/or prevention rhinitis which characterized in that, includes gauze mask body (1), medicine storage bag (2) and traditional chinese medicine inserted sheet (3), wherein:
a medicine storage bag (2) is arranged on the outer side or the inner side of the mask body (1);
the medicine storage bag (2) is provided with only one opening, and the opening end of the medicine storage bag (2) is provided with a magic tape (202) for opening or closing the opening;
the traditional Chinese medicine inserting pieces (3) can pass through the opening of the medicine storage bag (2) to enter and exit the medicine storage bag (2).
6. The mask for the treatment and/or prevention of rhinitis according to claim 5, wherein the pouch (2) is provided inside the mask body (1).
7. The mask for treating and/or preventing rhinitis according to claim 6, wherein the drug storage bag (2) is provided with a plurality of air vents (201).
8. The mask for treating and/or preventing rhinitis according to any one of claims 5 to 7, wherein the drug storage bag (2) is made of hygroscopic exothermic fibers.
9. A method for preparing a mask for treating and/or preventing rhinitis according to any one of claims 1 to 8, which comprises the steps of firstly taking a mask body (1), then sewing a medicine storage bag (2) on the inner side of the mask body (1), then putting a traditional Chinese medicine insertion piece (3) into the medicine storage bag (2) from an opening of the medicine storage bag (2), and finally sealing the opening of the medicine storage bag (2) by a magic tape (202) to obtain the mask for treating and/or preventing rhinitis.
10. The preparation method of the mask for treating and/or preventing rhinitis according to claim 9, wherein the preparation steps of the traditional Chinese medicine insert (3) are as follows:
s1, adding water into flos Magnoliae, fructus Xanthii, herba Menthae, radix Angelicae Dahuricae, fructus Gardeniae, radix bupleuri, herba asari, rhizoma Chuanxiong, radix astragali, caulis Clematidis Armandii, radix Platycodonis, and Poria at above ratio, distilling at least once, and collecting distillate and residue;
s2, sequentially decocting and concentrating the decoction dregs obtained in the step S1, adding ethanol to enable the alcohol content to reach 67-74 wt%, and concentrating to obtain an alcohol extract;
s3, adding water into the scutellaria baicalensis according to the proportion, decocting and concentrating, and adjusting the pH value to 1.5-2 to obtain scutellaria baicalensis precipitates;
s4, mixing the distillate in the step S1, the alcohol extract in the step S2 and the scutellaria baicalensis precipitate in the step S3 to obtain an extracted liquid medicine;
s5, mixing and stirring peach gum, tragacanth gum and distilled water, and swelling to obtain a first mixture;
s6, mixing and stirring the sodium polyacrylate and the distilled water under the water bath condition to fully swell the sodium polyacrylate and the distilled water to obtain a second mixture;
s7, mixing the first mixture and the second mixture, and heating and stirring the mixture under the condition of water bath until the mixture is completely dissolved to obtain a third mixture;
s8, mixing the powdery silica gel, the activated carbon, the titanium dioxide, the azone and the third mixture, and heating and uniformly stirring the mixture under the water bath condition to obtain a fourth mixture; uniformly dispersing the dihydroxyaluminum glycerolate by using glycerol, and uniformly mixing and stirring the mixture and the fourth mixture to obtain a sustained and controlled release matrix;
s9, uniformly mixing the sustained and controlled release matrix with the extracted liquid medicine obtained in the step S4, heating the mixture in water bath, continuously stirring and refining the mixture to a concentrated solution state, and finally sequentially coating, drying, sticking an anti-sticking film and slicing the lining cloth to obtain the traditional Chinese medicine inserting piece (3).
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