CN113069519A

CN113069519A - Anti-inflammatory itching-relieving hair washing formula and preparation method and using method thereof

Info

Publication number: CN113069519A
Application number: CN202110399624.5A
Authority: CN
Inventors: 吴耀松; 陈玉龙; 刘燕; 刘俊; 彭梦薇; 郝羚伦; 张艳
Original assignee: Henan University of Traditional Chinese Medicine HUTCM
Current assignee: Henan University of Traditional Chinese Medicine HUTCM
Priority date: 2021-04-14
Filing date: 2021-04-14
Publication date: 2021-07-06
Anticipated expiration: 2041-04-14
Also published as: CN113069519B

Abstract

The invention discloses an anti-inflammatory itching-relieving hair washing formula as well as a preparation method and a use method thereof, and the technical scheme is that the hair washing formula comprises the following raw materials: 25-35g of cacumen biotae, 25-35g of honeysuckle, 15-25g of houttuynia cordata, 5-8g of mint, 10-20g of evening primrose, 10-15g of codonopsis pilosula, 10-20g of aloe, 5-7g of fructus amomi, 8-12g of saponin, 5-15g of chrysanthemum and 800ml of rice water. The anti-inflammatory itching-relieving shampoo disclosed by the invention takes pure natural traditional Chinese medicines as raw materials, has the advantages of wide raw material sources, low cost, green and safe use, no harmful components, no harm to a human body or dependence on the human body, capability of ensuring the health of the human body to the greatest extent, obvious effect and good treatment effect on scalp inflammation and pruritus, and provides a new traditional Chinese medicine formula for maintaining the scalp by the traditional Chinese medicines.

Description

Anti-inflammatory itching-relieving hair washing formula and preparation method and using method thereof

Technical Field

The invention relates to an anti-inflammatory itching-relieving hair washing formula and a preparation method and a using method thereof, belonging to the technical field of traditional Chinese medicines.

Background

In recent years, with the increase of health consciousness, people pay more attention to their health, and the scalp is the second most sensitive part of the human skin in different parts than the face and the hand. The results of the survey showed that 70% of healthy men and women had scalp problems all the year round. The scalp itching is a disease caused by nerve dysfunction of scalp, and the disease is mostly caused by exogenous wind evil, gastrointestinal damp-heat, internal disturbance of blood heat or malnutrition of qi and blood deficiency and the like in traditional Chinese medicine. The causes of scalp itching vary from hair quality to hair quality. According to the living habits of people in the current society, scalp itching is mainly caused by heat and deficiency. At present, chemical components such as chemical climbazole, ketoconazole and the like are commonly used in shampoo in the market. The former is more focused on removing dandruff, while ketoconazole, which has a good antipruritic effect, has been banned from safety problems. Moreover, after long-term use of chemical agents, the scalp is liable to be dependent on chemical components and the health of the scalp is impaired, so that there is a strong demand for antipruritic agents that are safe, effective and inexpensive.

Inflammation (inflammation) is a defense response of the body to stimuli, manifested by redness, swelling, heat, pain, and dysfunction. It may or may not be infectious inflammation due to infection. The local manifestations are most obvious when the body surface is inflamed, and are often manifested as red, swelling, heat, pain and dysfunction, and the mechanism is as follows: red: is caused by the blood filling in the inflammation focus, and the local oxyhemoglobin is increased due to arterial hyperemia at the initial stage of inflammation, so the inflammation is bright red. With the development of inflammation, blood flow is slow, blood stasis and stagnation, and local tissues contain more reduced hemoglobin, so that the local tissues are dark red. Swelling: mainly due to exudates, especially inflammatory edema. In chronic inflammation, tissue and cell proliferation can also cause local swelling. Thirdly, heating: heat is caused by arterial congestion and enhanced metabolism, and is caused by interleukin-8 (IL-8), Tumor Necrosis Factor (TNF), and prostaglandin E (PGE). Pain: factors that cause local pain in inflammation are associated with various factors. Accumulation of potassium ions, hydrogen ions, especially the stimulation of inflammatory mediators such as prostaglandins, 5-hydroxytryptamine, bradykinin, etc., within the focal site of local inflammation is a major cause of pain. The inflamed organ swells, increasing the tension of the capsule rich in sensory nerve endings, and the nerve endings are pulled to cause pain. Dysfunction: such as degeneration, necrosis and metabolic dysfunction of parenchymal cells in the inflammatory foci, and mechanical obstruction, compression, etc. caused by inflammatory exudates, may cause dysfunction of the inflamed organs. The inflammation of scalp is manifested as small-scale white dandruff, such as pityros or greasy scale patch, thick scab covered on the whole head of the serious person, and hair loss, which are the phenomena of inflammatory reaction, and the treatment of inflammation is mainly based on chemical agents at present.

The traditional Chinese medicine is from nature, pure normal temperature and mild, has small toxic and side effects, and is safer and more reliable compared with chemical synthetic products, so that the Chinese herbal medicine shampoo is more and more favored by people, but the traditional Chinese herbal medicine shampoo products are relatively few, and the using requirements are difficult to meet.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide an anti-inflammatory itching-relieving hair washing formula, a preparation method and a use method thereof, wherein the hair washing formula is safe, has no toxic or side effect, and has good anti-inflammatory itching-relieving effect.

In order to achieve the purpose, the technical scheme of the invention is as follows:

an anti-inflammatory itching-relieving hair washing formula comprises the following raw materials: 25-35g of cacumen biotae, 25-35g of honeysuckle, 15-25g of houttuynia cordata, 5-8g of mint, 10-20g of evening primrose, 10-15g of codonopsis pilosula, 10-20g of aloe, 5-7g of fructus amomi, 8-12g of saponin, 5-15g of chrysanthemum and 800ml of rice water.

The preparation method of the rice swill comprises the following steps: adding 600 plus 800ml of purified water into 0.5kg of rice, mixing and stirring, filtering for the first time, adding water with the same volume into the rice again, mixing and stirring, and filtering for the second time to obtain secondary filtrate, namely the rice swill. Because the rice swill is difficult to collect, 2kg of rice flour and 100kg of water can be fully stirred to replace the rice swill for use in industrial large-scale production.

A preparation method of an anti-inflammatory itching-relieving hair washing formula comprises the steps of mixing raw materials except rice swill, adding purified water, immersing the raw materials, boiling with strong fire, turning to mild fire, decocting for 20-30 minutes, filtering, reserving filtrate, repeating for three times, combining the filtrates, concentrating by a rotary evaporator to 1/3-1/4 of the volume of the rice swill, and adding the rice swill to obtain the anti-inflammatory itching-relieving hair washing formula.

An application method of an anti-inflammatory itching-relieving hair washing formula comprises directly or after diluting the anti-inflammatory itching-relieving hair washing formula.

The invention has the following pharmacological effects of the raw materials of the traditional Chinese medicine:

lateral burl leaf: bitter and astringent taste, cold in nature; it enters lung, liver and spleen meridians. Has the effects of cooling blood, stopping bleeding, eliminating phlegm, relieving cough, promoting hair growth and blackening hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature gray hair.

Honeysuckle flower: sweet taste and cold nature. It enters lung and stomach meridians. Has the effects of clearing away heat and toxic materials, relieving inflammation, and relieving swelling. It can be used for treating fever due to affection of exogenous wind-heat or epidemic febrile disease, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases.

Houttuynia cordata: pungent flavor and slightly cold. It enters lung meridian. Has the effects of clearing away heat and toxic materials, eliminating carbuncle, expelling pus, promoting urination, and treating stranguria. It can be used for treating lung abscess, emesis, phlegm heat, cough, dysentery, pyretic stranguria, carbuncle, swelling, and skin ulcer.

Mint: pungent taste and cool nature. It enters lung and liver meridians. Has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation. Can be used for treating wind-heat common cold, headache, sore throat, food stagnation, flatulence, aphtha, toothache, scabies, urticaria, early stage of epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, and hypochondriac pain.

Evening primrose: sweet and bitter in flavor and warm in nature. It enters liver, spleen and kidney meridians. Has effects of dispelling pathogenic wind and removing dampness, and strengthening tendons and bones. It can be used for treating arthralgia due to wind-cold-dampness, and soreness of bones and muscles.

Codonopsis pilosula: sweet in flavor and neutral in nature. It enters spleen and lung meridians. Has the effects of invigorating spleen, replenishing qi, and promoting fluid production. Can be used for treating weakness of spleen and stomach, deficiency of both qi and blood, asthenia, anorexia, thirst, chronic diarrhea, and proctoptosis.

Aloe vera: bitter taste and cold nature. It enters liver and large intestine meridians. Has the functions of purgation, clearing away liver heat and killing parasite. It can be used for treating constipation due to heat accumulation, headache due to liver fire, conjunctival congestion, convulsion, abdominal pain due to parasitic infestation, scabies, tinea, and hemorrhoid complicated with fistula.

Amomum fruit: pungent flavor and warm nature. It enters spleen, stomach and kidney meridians. Has effects of eliminating dampness, promoting appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage. Can be used for treating damp turbidity obstruction in middle energizer, abdominal distention, inappetence, deficiency-cold of spleen and stomach, emesis, diarrhea, vomiting, threatened abortion, and threatened abortion.

And (2) Chinese honeylocust fruit: warm in nature, pungent and salty in flavor. Has little toxicity. It enters lung and large intestine meridians. Has effects of inducing resuscitation, eliminating phlegm, resolving hard mass, relieving swelling, moistening dryness, and relaxing bowels. It can be used for treating phlegm cough, asthma, apoplexy, vomiting, excessive phlegm and saliva, unconsciousness, epilepsy, pharyngitis, constipation, carbuncle, swelling, and scabies.

Chrysanthemum: bitter and sweet in taste, slightly cold in nature. It enters lung and liver meridians. Has the effects of dispelling wind, clearing heat, calming liver, improving eyesight, and clearing away heat and toxic materials. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling.

Rice swill, Yu Hao in the book of the present records has the following statement: "Sundabizu, mu millet and beam. The 'bath' is hair washing, namely the 'bath millet' is used for washing hair, namely the washing millet water is used for washing hair, and the rice swill has been applied to hair care and hair washing in ancient times. Modern medicine proves that rice swill contains abundant B vitamins which can help pigment cells of hair to generate black pigment, so that the hair can be blackened, and the rice swill contains alkaloid, is a good detergent, can enable the hair to be easily cleaned, does not cause dandruff, does not cause greasy feeling of the hair, keeps fresh and is not easy to adhere dust. In addition, the hair loss caused by dirt blocking scalp pores can be prevented, the scalp can be kept fresh, and the scalp can not be itchy.

In the formula, the Chinese arborvitae twig, folium Platycladi is bitter and astringent in taste and cold in property, has the functions of cooling blood, relieving itching, dispelling wind-damp, eliminating swelling and toxin, growing hair and blackening hair, and is a monarch drug. Honeysuckle flower, pungent and cool, has the functions of dispelling wind and heat, clearing away heat and toxic material. The herb of houttuynia cordata, pungent and slightly cold in property, can clear heat and remove toxicity, cure abscess and expel pus, induce diuresis and treat stranguria. Evening primrose, bitter; being warm in nature, it can dispel wind, remove dampness, resolve swelling and heal wound. Aloe, bitter and cold, has the effects of clearing heat, relaxing bowels and killing parasites. The 4 medicines help monarch medicines to clear away heat and toxic materials, diminish inflammation and relieve itching and are used as ministerial medicines together. Mint and chrysanthemum, pungent and cool, dispelling wind and clearing heat, and detoxifying and relieving itching; chinese honeylocust fruit, pungent and warm in flavor, dispel wind-phlegm, remove dampness and toxicity, kill parasites and relieve itching; fructus amomi, pungent and warm in property, invigorate spleen, resolve dampness and promote appetite; radix Codonopsis, sweet and warm, invigorates spleen and invigorates qi; the rice swill is sweet and cool, and can tonify qi, detoxify and moisten hair; the 6 medicines can help ministerial medicines to detoxify and relieve itching, strengthen body resistance and eliminate evil, nourish hair quality, and are used as adjuvant and conductant medicines together. The 11 medicines have the effects of clearing heat and removing toxicity, resisting inflammation and relieving itching and protecting hair.

The invention has the beneficial effects that:

the anti-inflammatory itching-relieving shampoo disclosed by the invention takes pure natural traditional Chinese medicines as raw materials, has the advantages of wide raw material sources, low cost, green and safe use, no harmful components, no harm to a human body or dependence on the human body, capability of ensuring the health of the human body to the greatest extent, obvious effect and good treatment effect on scalp inflammation and pruritus, and provides a new traditional Chinese medicine formula for maintaining the scalp by the traditional Chinese medicines.

Drawings

FIG. 1 shows the clinical observation effect of the anti-inflammatory antipruritic shampoo.

Detailed Description

The following examples further illustrate the embodiments of the present invention in detail.

The preparation method of the rice swill comprises the following steps: adding 600 plus 800ml of purified water into 0.5kg of rice, mixing and stirring, filtering for the first time, adding water with the same volume into the rice again, mixing and stirring, and filtering for the second time to obtain secondary filtrate, namely the rice swill.

Example 1

An anti-inflammatory itching-relieving hair washing formula comprises the following raw materials: 30g of cacumen biotae, 30g of honeysuckle, 20g of houttuynia cordata, 6g of mint, 15g of evening primrose, 12g of codonopsis pilosula, 15g of aloe, 6g of fructus amomi, 10g of saponin, 10g of chrysanthemum and 800ml of rice swill.

The preparation method comprises the following steps: mixing the raw materials except the rice swill, adding purified water, immersing the raw materials, boiling with strong fire, turning to mild fire, decocting for 30 minutes, filtering, leaving filtrate, repeating for three times, combining the filtrates, concentrating to 200ml by a rotary evaporator, and adding the rice swill to obtain the anti-inflammatory antipruritic shampoo.

Example 2

An anti-inflammatory itching-relieving hair washing formula comprises the following raw materials: 25g of cacumen biotae, 25g of honeysuckle, 15g of houttuynia cordata, 5g of mint, 10g of evening primrose, 10g of codonopsis pilosula, 10g of aloe, 5g of fructus amomi, 8g of saponin, 5g of chrysanthemum and 600ml of rice swill.

Example 3

An anti-inflammatory itching-relieving hair washing formula comprises the following raw materials: 35g of cacumen biotae, 35g of honeysuckle, 25g of houttuynia cordata, 8g of mint, 20g of evening primrose, 15g of codonopsis pilosula, 20g of aloe, 7g of fructus amomi, 12g of saponin, 15g of chrysanthemum and 800ml of rice water.

Effect testing experiment

1 rat egg white plantar swelling experiment

24 SD rats were randomly divided into 6 groups, namely an administration group (three groups with high, medium and low doses), a positive control group, a model group and a normal control group, wherein each group contains 4 rats.

The anti-inflammatory antipruritic shampoo prepared in example 1 is used as a drug administration group, wherein the anti-inflammatory antipruritic shampoo is prepared by taking 100% of stock solution and adding distilled water to dilute the 100% of stock solution into 50% and 20% of the stock solution; the positive control group is FUYINJIELONGSONG lotion (Guangxi Yuanyangtang pharmaceutical Co., Ltd.) containing oleum Baeckeae, oleum Eucalypti, oleum Rhododendri Simsii, oleum Cnidii, Concha Haliotidis, Kochiae fructus, cortex Phellodendri, and chlorhexidine acetate. The adjuvants are polysorbate 80 and sodium benzoate.

The swelling degree of the foot sole of the rat is measured by volume measurement, after the left forefoot of each group of rats is subjected to depilation treatment, the initial volume is measured, the left forefoot of each group except the normal control group is injected with 100% fresh egg white subcutaneously at the foot sole of the left forefoot, 0.03ml is added, the volume of the left forefoot of each group of rats is measured after 0.5h, and the depilation part is smeared with: normal control group and model group are smeared with physiological saline, positive control group is smeared with Fuyinjie compound yellow pine lotion, three groups of administration are respectively smeared with anti-inflammatory and antipruritic shampoo with concentration of 100% (high dose), 50% (medium dose) and 20% (low dose) on the left foot of each group of rats, each time is 0.1ml/100g, 2 times/day, and the application lasts 2 days. After the last smearing for 1h, the volume of the left forefoot of the rat is detected again, and the swelling degree is used as a detection index. The swelling rate and the swelling inhibition rate were determined by the following formulas: swelling degree E (%) - (Vt-Vn)/Vn × 100%, wherein Vn and Vt, respectively represent the volume values of the metatarsal before and after application of an inflammatory agent; swelling degree inhibition ratio I (%) (Ec-Et)/Ec × 100%, where Et and Ec represent the average swelling degree of the administration group and the model group, respectively, and data analysis was performed using SPSS l8.0 statistical software; the measurement data is expressed by (x +/-s), and single-factor analysis of variance is selected according to whether the measurement data is normally distributed or not; p is less than 0.05, which has statistical significance. The results are shown in Table 1.

TABLE 1 Effect of anti-inflammatory antipruritic shampoo on toe swelling in rats

Note: compared with the normal control group,^*represents P < 0.05; in comparison with the set of models,^△represents P < 0.05.

The plantar swelling model is a classic acute inflammation model commonly used to evaluate or screen for anti-inflammatory effects of drugs. In the research, a pathological model of a rat is established, pharmacological effects of different medicines on inflammation are investigated, in a rat foot sole swelling experiment, by injecting fresh egg white to rat foot soles subcutaneously, histamine, 5-HT and other inflammation mediators are released, local capillary vessel hyperpermeability, exudation and edema are caused, early acute inflammation manifestations such as redness, swelling, heat, pain and the like of the foot soles are caused, and the reaction is similar to the reaction of human acute inflammation. As can be seen from Table 1, compared with the normal control group, the toe swelling degree of each group of the model group, the anti-inflammatory itching-relieving shampoo and the positive control group of Fuyinjie cleansing are obviously increased, and the statistical significance (P is less than 0.05) is achieved, so that the success of the acute inflammation model modeling is proved.

The swelling degree inhibition rate can reflect the inflammation inhibition effect of the medicine. As can be seen from Table 1, compared with the model group, the swelling degree of the high-dose group and the positive control group of Fuyinjie in the anti-inflammatory itching-relieving shampoo is obviously reduced, and the statistical significance is achieved (P is less than 0.05); the swelling degree inhibition rate is increased along with the increase of the concentration of the shampoo, the effect is more and more obvious, and the dose dependence is presented; the high-concentration anti-inflammatory antipruritic formula has the same effect as the positive skin-yin cleaning medicine.

2 rat itch-causing experiment

Healthy female SD rats, weighing 180. + -.20 g. 24 rats were randomly divided into 6 groups of three dosing groups, a positive control group, a model group and a normal control group, 4 rats each.

1h before the experiment, after shaving the left hind paw of the rat, the area of the left hind paw is 1cm²The rat becomes red and is coated with 0.1 ml/foot, wherein the left foot of each rat in the administration group is coated with 100% (high dose), 50% (medium dose) and 20% (low dose) of anti-inflammatory and antipruritic shampoo, the positive control group is coated with Fuyinjie compound yellow pine lotion, and the normal control group and the model group are coated with normal saline. Then 0.05% histamine phosphate (normal control group is smeared with equal amount of normal saline) is dripped on the wound surface, 0.05 ml/rat, and if the rat does not lick and abrade skin within 3minSkin movement, smearing 1 time of histamine phosphate again, and repeating the operation until the rat licks the hind paw by turning back. The itching threshold of each group of rats was calculated based on the total amount of histamine phosphate applied to compare the antipruritic effects of the anti-inflammatory antipruritic shampoo. Performing data analysis by using SPSS l8.0 statistical software; the measurement data is expressed by (x +/-s), and single-factor analysis of variance is selected according to whether the measurement data is normally distributed or not; p is less than 0.05, which has statistical significance. The results are shown in Table 2.

TABLE 2 influence of anti-inflammatory antipruritic shampoo on skin itching in rats

Note: in comparison with the set of models,^*represents P < 0.05; compared with the positive control group of the Skinpro lotion,^△represents P < 0.05.

As can be seen from Table 2, compared with the model group, the itching threshold of each group of the anti-inflammatory itching-relieving hair washing formula is obviously increased (P is less than 0.05), wherein the itching threshold of the 100% anti-inflammatory shampoo is the highest, which indicates that the effect of relieving itching of the 100% anti-inflammatory itching-relieving hair washing formula is better than that of the middle-low dose group; compared with a positive control group of the Skinpro lotion, the moderate-low anti-inflammatory itching-relieving shampoo formula has obviously reduced itching threshold, has statistical significance (P is less than 0.05), has no obvious difference in high-dose groups, has no statistical significance (P is more than 0.05), and shows that the effect of the high-concentration anti-inflammatory itching-relieving shampoo is equivalent to the Skinpro lotion.

3 safety test

Depilating 3cm of the right dorsal side of each group of rats²The medicine is wiped off after being applied for 3 times/d and 2d, wherein three groups of the administration group are respectively coated with anti-inflammatory and itching relieving shampoo with the concentration of 100% (high dose), 50% (medium dose) and 20% (low dose), the positive control group is coated with Fuyinjie compound yellow pine lotion, the model group is coated with normal saline, and the normal control group is not coated. The appearance of erythema and redness at the administration site was recorded 1h, 5h and 9h after the end of the administration. The results are shown in Table 3.

TABLE 3 Effect of anti-inflammatory antipruritic shampoo on stimulation of intact skin in rats

As can be seen from table 3, no erythema occurs in the normal control group, the model group and the 50% anti-inflammatory antipruritic shampoo, a large area of dark red scabs occurs in the skincare positive control group, and a small amount of erythema occurs in one rat of the 100% anti-inflammatory antipruritic shampoo, which indicates that the irritation of the skincare positive control group is strong, the probability of erythema generation in the rat is high, the irritation of the anti-inflammatory antipruritic shampoo is weak, and the erythema generation degree of the low-concentration anti-inflammatory antipruritic shampoo is lower than that of the high-concentration anti-inflammatory antipruritic shampoo. According to the skin irritation grading standard, the irritation intensity evaluation score of the anti-inflammatory itching-relieving hair washing formula is less than 0.5, which shows that the anti-inflammatory itching-relieving hair washing formula basically has no irritation to the intact skin of rats and has extremely high safety.

4 degree of inflammation test in rats

The experimental rats in each group in experiment 1 are anesthetized with urethane accounting for 20% of mass fraction, fixed on a frog board in a supine manner, the abdominal cavity is cut open along the median line of the abdomen by surgical scissors after disinfection, a cotton ball or gauze is dipped to remove exuded blood, the abdominal aorta (light red with jumping motion) is found out, and the abdominal aorta is separated by a glass needle. Preparing a blood taking needle and a 10ml blood taking tube containing an EDTA anticoagulant according to the blood demand, carrying out needle insertion along the abdominal aorta by the right hand, and sucking 8-10 ml of blood. Standing the collected blood for 2h, placing in a centrifuge, rotating at 3000 rpm for 20min to extract 1ml of serum, and detecting IL-8 factor concentration in the serum by enzyme-linked immunosorbent assay. Performing data analysis by using SPSS l8.0 statistical software; the measurement data is expressed by (x +/-s), and single-factor analysis of variance is selected according to whether the measurement data is normally distributed or not; p is less than 0.05, which has statistical significance. The results are shown in Table 4.

TABLE 4 comparison of IL-8 inflammatory factors in various groups of rats

Note: compared with the normal control group,^△represents P < 0.05; in comparison with the set of models,^﹟represents P < 0.05; compared with the positive control group of the Skinpro lotion,^*represents P < 0.05.

The level of IL-8 may reflect the degree of inflammation, with higher inflammation being more severe. As can be seen from Table 4, compared with the normal control group, the IL-8 concentration of the model group has obvious change (P is less than 0.05), which indicates that the molding is successful; compared with the model group, the concentration of IL-8 in each group except the low dose group is obviously changed (P is less than 0.05); compared with a positive control group of the Skinpro lotion, the 100 percent anti-inflammatory itching-relieving shampoo formula group has no obvious difference (P is more than 0.05), which indicates that the inflammation-inhibiting effect and the Skinpro lotion effect of the high-dose anti-inflammatory itching-relieving formula are equivalent.

5 clinical observation of curative effect of medicine

The 100% anti-inflammatory and antipruritic shampoo is applied to scalp of human for 1 day/time, and is applied for 1 time for 3min for 30 days. According to the scalp detector specification, pictures are collected, and the clinical medicinal value of the anti-inflammatory itching-relieving hair washing formula is detected. The results are shown in FIG. 1.

As can be seen from the comparison of the photographs before and after the use of the shampoo shown in FIG. 1, the oil and dandruff of the testee are obviously reduced, the hair brightness is reduced after the use, and the scalp of the testee has no erythema and redness after the use, which shows that the 100 percent anti-inflammatory and itching relieving shampoo has excellent curative effect and extremely high safety.

Conclusion

The external treatment method plays an important role in treating scalp problems, and the traditional Chinese medicine can directly act on the affected part through external washing, so that the utilization rate of the medicine can be greatly improved. The traditional Chinese medicine has long been used for treating by external washing with traditional Chinese medicine decoction, which accords with the concept of 'surgical method, and emphasizes external treatment'. The traditional Chinese medicine considers that the disease is mostly caused by external attack of wind evil, gastrointestinal damp-heat, internal disturbance of blood heat or malnutrition of qi and blood deficiency, and the like, and externally treats the disease by selecting agents for clearing heat, drying dampness, dispelling wind, nourishing, killing insects and relieving itching. According to the pharmacological component analysis of the medicine and the record of the effect of the ancient book, the traditional Chinese medicine is reasonably compatible, so that the effects of nourishing the five internal organs, tonifying qi and blood, dredging the channels and collaterals, promoting blood circulation to remove blood stasis, dispelling wind and clearing heat, cooling blood and removing toxicity, eliminating dampness and relieving itching and the like are achieved.

Claims

1. The anti-inflammatory itching-relieving hair washing formula is characterized by comprising the following raw materials: 25-35g of cacumen biotae, 25-35g of honeysuckle, 15-25g of houttuynia cordata, 5-8g of mint, 10-20g of evening primrose, 10-15g of codonopsis pilosula, 10-20g of aloe, 5-7g of fructus amomi, 8-12g of saponin, 5-15g of chrysanthemum and 800ml of rice water.

2. The anti-inflammatory antipruritic shampoo according to claim 1 comprising the following raw materials: 30g of cacumen biotae, 30g of honeysuckle, 20g of houttuynia cordata, 6g of mint, 15g of evening primrose, 12g of codonopsis pilosula, 15g of aloe, 6g of fructus amomi, 10g of saponin, 10g of chrysanthemum and 800ml of rice swill.

3. The anti-inflammatory antipruritic shampoo according to claim 1 or 2 wherein the rice water is prepared by the following steps: adding 600 plus 800ml of purified water into 0.5kg of rice, mixing and stirring, filtering for the first time, adding water with the same volume into the rice again, mixing and stirring, and filtering for the second time to obtain secondary filtrate, namely the rice swill.

4. The method for preparing the anti-inflammatory antipruritic shampoo according to claim 1 or 2, wherein the raw materials except rice water are mixed, purified water is added, the raw materials are immersed, boiled with strong fire, boiled with mild fire for 20-30 minutes, filtered, the filtrate is remained, repeated for three times, the filtrates are combined, concentrated by a rotary evaporator to 1/3-1/4 of the volume of the rice water, and the rice water is added to obtain the anti-inflammatory antipruritic shampoo.

5. A method of using the anti-inflammatory antipruritic shampoo according to claim 1 or 2, wherein the anti-inflammatory antipruritic shampoo is used directly or after dilution.