CN113069120B - Photoelectric fusion type brain electrode - Google Patents

Photoelectric fusion type brain electrode Download PDF

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Publication number
CN113069120B
CN113069120B CN202110377279.5A CN202110377279A CN113069120B CN 113069120 B CN113069120 B CN 113069120B CN 202110377279 A CN202110377279 A CN 202110377279A CN 113069120 B CN113069120 B CN 113069120B
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electrode
photoelectric
brain
photoelectric sensor
signals
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CN113069120A (en
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李双
傅翼斐
陈皓
牛兰
康晓洋
张锐
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Ji Hua Laboratory
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Ji Hua Laboratory
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow
    • A61B5/0261Measuring blood flow using optical means, e.g. infrared light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow
    • A61B5/0295Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Biophysics (AREA)
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  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention discloses a photoelectric fusion brain electrode, which comprises an electrode body, wherein a photoelectric sensor which is positioned in the middle of the electrode body and is based on photoplethysmography is arranged on the electrode body, and an electrode assembly which surrounds the outer side of the photoelectric sensor is also arranged on the electrode body. The photoelectric fusion brain electrode can collect scalp blood flow signals and brain electrical signals at the same collection point at the same time, is convenient for observing synchronous changes of the two signals at the collection point, can obtain a large amount of human physiological information through analysis, and is beneficial to multichannel brain electrical health monitoring analysis; in addition, when the photoelectric fusion brain electrode is used, the electrode assembly can be used for starting the hair, so that the problem that the detection accuracy of the photoelectric sensor is affected due to the fact that signal absorption caused by hair is weakened is avoided, the electrode assembly arranged on the outer side of the photoelectric sensor in a surrounding mode can block light signals emitted by the photoelectric sensor and scattered outwards, and the fact that the light signals are scattered into the nearby photoelectric fusion brain electrode to affect the detection result of the nearby photoelectric fusion brain electrode is avoided.

Description

Photoelectric fusion type brain electrode
Technical Field
The invention relates to the technical field of human body monitoring, in particular to a photoelectric fusion type brain electrode.
Background
EEG (Electroencephalography) refers to a method of recording brain activity using electrodes. The scalp electroencephalogram signal contains a large amount of information closely related to human health, and provides important references for disease prevention and brain-computer interface research.
PPG (photoplethysmograph) is a technical method for measuring and recording the pulse state of a blood vessel by utilizing photoelectric volume pulse waves so as to obtain health parameters such as heart rate, blood oxygen saturation and the like.
EEG signals and blood flow signals can be respectively acquired by using the EEG and the PPG, and the two signals can be acquired by comprehensively analyzing the EEG signals and the blood flow signals, and in the prior art, the acquisition of the two signals is separately and independently carried out, the acquired information at different positions has a certain deviation, and the two information lacks relevance including the reference of position and time; and when PPG is adopted to acquire blood flow information at different positions at the same time, adjacent sensors can generate optical signal crosstalk, and measurement accuracy is affected.
Accordingly, the prior art is still in need of improvement and development.
Disclosure of Invention
In view of the shortcomings of the prior art, an object of the embodiment of the application is to provide a photoelectric fusion type brain electrode, which can simultaneously acquire brain electrical signals and blood flow signals of the same acquisition point, is beneficial to comprehensive analysis of human health, can avoid optical crosstalk generated by a proximity sensor, and improves PPG measurement accuracy.
The embodiment of the application provides a photoelectric fusion brain electrode, which comprises an electrode body, wherein a photoelectric sensor which is positioned in the middle of the electrode body and is based on photoplethysmography is arranged on the electrode body, and an electrode assembly which surrounds the outer side of the photoelectric sensor is also arranged on the electrode body.
The photoelectric fusion brain electrode can collect scalp blood flow signals and brain electrical signals at the same collection point at the same time, and is convenient for observing synchronous changes of the two signals at the collection point; in addition, the electrode assembly arranged on the outer side of the photoelectric sensor in a surrounding mode can block light signals emitted by the photoelectric sensor and scattered outwards, and the problem of light crosstalk is avoided.
The photoelectric fusion brain electrode comprises a photoelectric sensor and a light source, wherein the photoelectric sensor comprises a plurality of LED light sources which are arranged side by side and used for emitting light signals, and a detector which is arranged on one side of each LED light source and used for receiving reflected light signals.
The photoelectric fusion brain electrode comprises three LED light sources, and the three LED light sources respectively emit green light, red light and infrared light.
The photoelectric fusion brain electrode is characterized in that the LED light source and the detector are respectively positioned at two sides of the center of the electrode body.
The photoelectric fusion brain electrode comprises an electrode assembly and a brain electrode, wherein the electrode assembly comprises more than two electrode probes which are arrayed at equal intervals along the circumference.
The photoelectric fusion brain electrode is characterized in that two adjacent electrode probes are arranged in a staggered mode.
The photoelectric fusion brain electrode is characterized in that the electrode body is cylindrical, and the axis line of the electrode body is coincident with the axis of the electrode probe array.
The photoelectric fusion brain electrode is characterized in that the electrode probe is one of cylindrical, round table-shaped and conical.
The photoelectric fusion brain electrode is characterized in that the electrode probe is a microneedle electrode.
The photoelectric fusion brain electrode is characterized in that a groove for installing a photoelectric sensor is formed in the middle of the electrode body, and the electrode assembly is located outside the groove.
From the above, the photoelectric fusion brain electrode provided by the embodiment of the application can collect scalp blood flow signals and brain electrical signals at the same collection point at the same time, is convenient for observing synchronous changes of the two signals at the collection point, can obtain a large amount of human physiological information through analysis, provides important basis for diagnosis and prevention of diseases, brain function research and the like, and is beneficial to multichannel brain electrical health monitoring analysis; in addition, when the photoelectric fusion brain electrode is used, the electrode assembly can be used for starting the hair, so that the problem that the detection accuracy of the photoelectric sensor is affected due to the fact that signal absorption caused by hair is weakened is avoided, the electrode assembly arranged on the outer side of the photoelectric sensor in a surrounding mode can block light signals emitted by the photoelectric sensor and scattered outwards, and the fact that the light signals are scattered into the nearby photoelectric fusion brain electrode to affect the detection result of the nearby photoelectric fusion brain electrode is avoided.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments of the present application will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and should not be considered as limiting the scope, and other related drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic perspective view of a photoelectric fusion brain electrode according to an embodiment of the present application.
Fig. 2 is a schematic top view of a photoelectric fusion brain electrode according to an embodiment of the present application.
Fig. 3 is a schematic side view of a photoelectric fusion brain electrode according to an embodiment of the present application.
Reference numerals: 1. an electrode body; 2. a photoelectric sensor; 3. an electrode assembly; 11. a groove; 21. an LED light source; 22. a detector; 23. a circuit board; 24. an electronic device; 25. a protruding end.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the application, as presented in the figures, is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by a person skilled in the art without making any inventive effort, are intended to be within the scope of the present application.
As shown in fig. 1-3, an embodiment of the present application provides a photoelectric fusion brain electrode, which comprises an electrode body 1, wherein a photoelectric sensor 2 which is positioned in the middle of the electrode body 1 and is based on photoplethysmography is arranged on the electrode body 1, and an electrode assembly 3 which surrounds the outer side of the photoelectric sensor 2 is also arranged on the electrode body 1.
The photoelectric sensor 2 based on photoplethysmography is a PPG (photoplethysmograph) -based photoelectric sensor 2, that is, the photoelectric sensor 2 can record the pulse state of a blood vessel by utilizing the measurement of a photoelectric volume pulse wave, so as to obtain health parameters such as heart rate, blood oxygen saturation and the like, and the photoelectric sensor should comprise an optical signal transmitting end, a reflected optical signal receiving end and a signal analysis module.
The electrode assembly 3 is used for measuring scalp electroencephalogram (Electroencephalography, EEG) signals, among others.
The photoelectric fusion type brain electrode is usually used in multiple simultaneous modes, namely, the multiple brain electrodes are fixed at different positions of the head at the same time to collect signals at different positions, and brain electrical signals and blood flow signals at different positions can be collected at the same time.
The photoelectric fusion brain electrode is provided with a photoelectric sensor 2 and an electrode assembly 3 based on photoelectric plethysmography, wherein the photoelectric sensor 2 is used for detecting brain activities, and the electrode assembly 3 is used for measuring scalp brain electrical signals; the photoelectric fusion brain electrode can be used for simultaneously collecting scalp blood flow signals and brain electrical signals at the same collecting point, is convenient for observing synchronous changes of the two signals at the collecting point, can obtain a large amount of human physiological information through analysis, and provides important basis for diagnosis and prevention of diseases, brain function research and the like.
More specifically, as the photoelectric fusion type brain electrode provided by the embodiment of the application is used simultaneously, two signals generated at the positions can be compared, and physiological conditions at different positions of the head can be analyzed, so that further important basis is provided for diagnosis and prevention of diseases, brain function research and the like.
When the photoelectric fusion brain electrode is used, hair can be pulled out through the electrode assembly 3, the problem that the detection accuracy of the photoelectric sensor 2 is affected due to weakening of signal absorption caused by the hair is avoided, in addition, the electrode assembly 3 arranged on the outer side of the photoelectric sensor 2 in a surrounding mode can block light signals emitted by the photoelectric sensor 2 and scattered outwards, and the problem that the detection result of the nearby photoelectric fusion brain electrode is affected due to the fact that the light signals are scattered into the nearby photoelectric fusion brain electrode, namely, the problem of light crosstalk is avoided.
More specifically, when the light signal emitted by the photoelectric sensor 2 is scattered to the electrode assembly 3, the scattered light signal is reflected in the electrode assembly 3 for multiple times and absorbed by the electrode assembly 3 to be attenuated, so that the scattered light signal is prevented from departing from the current position of the photoelectric fusion brain electrode and entering the adjacent photoelectric fusion brain electrode to influence the measurement result of the photoelectric sensor 2 of the adjacent photoelectric fusion brain electrode.
The middle part of the electrode body 1 of the photoelectric fusion type brain electrode is provided with a signal wire connected with external signal display equipment or analysis equipment, and after signals are acquired through the brain electrode, the signals are transmitted to the external signal display equipment or the analysis equipment through the signal wire.
In some preferred embodiments, the photosensor 2 comprises a plurality of LED light sources 21 arranged side by side for emitting light signals and a detector 22 arranged on one side of the LED light sources 21 for receiving reflected light signals; the LED light source 21 emits light signals for detection towards the scalp, the light sources with different wavelengths have different detection depths for cerebral cortex, the light signals are reflected by the cerebral cortex to form reflected light signals, the detector 22 is used for receiving and measuring the reflected light signals, the detector 22 can measure the reflected light signals reflected by blood of the cerebral cortex to obtain an electrocardio R-R interval, further atrial fibrillation can be detected through analysis, and simultaneously, the indexes of cerebral vascular hemodynamics can be measured to judge and predict cerebral apoplexy; the partially reflected light signal formed by the reflection of the light signal is scattered outside the electrode body 1, and the electrode assembly 3 can block the reflected light signal emitted by the photoelectric sensor 2 and scattered outside.
The detector 22 reads the reflected light signals reflected from the scalp and converts the reflected light signals into corresponding blood flow signals to measure the human health parameters such as heart rate, scalp blood flow, blood oxygen saturation and the like.
In addition, the plurality of LED light sources 21 are arranged side by side, so as to generate light signals emitted side by side, ensure that the light signals of different LED light sources 21 have similar incident angles, and facilitate a single detector 22 to receive reflected light signals generated by reflection of the light signals of different LED light sources 21.
In some preferred embodiments, the photoelectric sensor 2 further includes a circuit board 23 fixed on the electrode body 1 and an electronic device 24 provided on the circuit board 23, the LED light source 21 and the detector 22 are provided on the circuit board 23, the LED light source 21 is used for emitting a detection light signal, the detector 22 is used for receiving an emission light signal emitted by the scalp, and the circuit board 23 and the electronic device 24 are used for converting the reflection light signal into an electrical signal for output.
In some preferred embodiments, the circuit board 23 is provided with a protruding end 25, the LED light source 21 and the detector 22 are both disposed on the protruding end 25, and the electronic device 24 is disposed on the circuit board 23 at a position outside the protruding end 25, so as to avoid the electronic device 24 from obstructing the LED light source 21 from emitting the light signal and avoid the electronic device 24 from obstructing the detector 22 from receiving the reflected light signal.
In certain preferred embodiments, the number of LED light sources 21 is three, and each emits green, red and infrared light; the detection depth of green light, red light and infrared light to the cerebral cortex is increased in sequence, and the infrared light is less interfered by the surface of the skin (sweat, oil and the like), so that the fusion brain electrode can adapt to various application occasions and can acquire blood information with different depths in different cerebral cortex.
More specifically, red light and infrared light generated by the LED light source 21 in the light sensor have different absorption coefficients for oxygenated hemoglobin (Hb) and hemoglobin (HbO 2) in the brain, and red light has a high absorption coefficient for hemoglobin, and infrared light has a high absorption coefficient for oxygenated hemoglobin, and the red light and infrared light are compared by measuring PPG signals of the red light and infrared light to obtain the blood oxygen saturation parameter.
Among them, the green wavelength is preferably 525nm, the red wavelength is preferably 660nm, and the infrared wavelength is preferably 940nm.
The substrate of a general brain electrode is usually soft, so that the upper electrode probe can be attached to the shape of the head for contact monitoring, therefore, the electrode body 1 of the brain electrode in the embodiment of the application is soft, and can be bent relative to the shape of the head, so that the electrode assembly 3 can be tightly connected with the head.
In certain preferred embodiments, the LED light source 21 and the detector 22 are located on either side of the center of the electrode body 1; the LED light source 21 and the detector 22 are arranged in different positions, so that the light emitted by the light source irradiates the cerebral cortex, travels a certain distance and is reflected back, the light can be just received by the detector 22, and the edge light signal emitted by the LED light source 21 is prevented from being directly collected by the detector 22, so that the light signal is prevented from directly affecting the measurement result of the detector 22.
In certain preferred embodiments, the electrode assembly 3 comprises more than two circumferentially equidistant arrays of electrode probes; the uniformity and the accuracy of the acquisition of the electroencephalogram signals can be ensured by the electrode probes of the circumferential array; in addition, the provision of more than two electrode probes allows the reflected light signal scattered outward to be reflected multiple times in the multiple electrode probes and absorbed by the electrode assembly 3 to be attenuated.
In some preferred embodiments, the adjacent electrode probes of the two adjacent electrode probes are arranged in a staggered manner, that is, as shown in fig. 2 and 3, the electrode probes of the two adjacent electrode probes are arranged in a staggered manner, so that the reflected light signals scattered outwards are blocked, the reflected light signals entering from the gaps between the electrode probes are reflected and attenuated for multiple times in the electrode probes in the outer layer, and the reflected light signals are effectively prevented from being scattered outside the electrode assembly 3.
In certain preferred embodiments, the electrode probes are distributed in a two-fold circumferential equidistant array, 20 per-fold electrode probe.
In some preferred embodiments, the electrode body 1 is cylindrical and flat, and its axis coincides with the electrode probe array axis, so that the electrode probes are circumferentially arranged along the edge of the electrode body 1; when the brain electrode in the embodiment of the application is installed on the head of a human body, the installation position of the electrode probe can be controlled by grabbing the round edge of the periphery of the electrode body 1, the head hair can be quickly dialed by the electrode probe through controlling the electrode body 1, and then the electrode probe can be fixed by pressing the back side edge of the electrode body 1.
In certain preferred embodiments, the electrode probe is one of cylindrical, frustoconical, conical; in this embodiment, the electrode probe is preferably in a shape of a truncated cone, which is beneficial for the electrode probe to pluck hair.
In some preferred embodiments, the electrode probe is a microneedle electrode, and most of microneedle matrix electrodes are based on MEMS technology, and only need puncture skin stratum corneum when in use, so that bleeding is avoided, and the electrode probe has the characteristics of low impedance and no displacement, and can accurately acquire brain electrical signals of the head; in the embodiment of the application, after the hair is pulled out by the microneedle electrode, the microneedle electrode can be penetrated into the skin of the head by pressing the edge of the back side of the electrode body 1, and the hair pulling device has the characteristic of convenient use.
In some preferred embodiments, the axis of the electrode probe is perpendicular to the end face where the electrode probe is connected to the electrode body 1, which facilitates the connection and fixation of the electrode probe and ensures that the electrode probe can be attached to the skin of the head.
When the microneedle motor is in one of a cylindrical shape and a truncated cone shape, the top end of the microneedle motor is provided with an antenna end for puncturing the stratum corneum of the skin.
In certain preferred embodiments, a groove 11 for mounting the photoelectric sensor 2 is formed in the middle of the electrode body 1, and the electrode assembly 3 is located outside the groove 11; the recess 11 is provided to mount the photoelectric sensor 2, so that on one hand, it is ensured that the light signal has a sufficient irradiation and reflection distance, and that the generated reflected light signal can be obtained by the detector 22 of the photoelectric sensor 2, and on the other hand, the light signal emitted horizontally from the LED light source 21 is blocked by the edge of the recess 11, and the light signal can be further prevented from being scattered from the electrode assembly 3.
More specifically, when the brain electrode according to the embodiment of the application is used, the electrode body 1 is attached to the head of a human body and is bent, so that the groove 11 is also in a bent state, the LED light source 21 is mounted based on the fixed circuit board 23, and part of the LED light source emits light signals towards the groove 11, is refracted by the groove 11 and then is emitted to the head of the human body, so that the light signals are converged, more reflected light signals related to blood flow signals can be obtained by the detector 22, and the detection accuracy is improved.
In summary, the photoelectric fusion brain electrode provided by the embodiment of the application can collect scalp blood flow signals and brain electrical signals at the same collection point at the same time, is convenient for observing synchronous changes of the two signals at the collection point, can obtain a large amount of human physiological information through analysis, provides important basis for diagnosis and prevention of diseases, brain function research and the like, and is beneficial to multichannel brain electrical health monitoring analysis; in addition, when the photoelectric fusion brain electrode is used, the hair can be pulled out through the electrode assembly 3, the problem that the detection precision of the photoelectric sensor 2 is affected due to the fact that signal absorption caused by the hair is weakened is avoided, the electrode assembly 3 arranged on the outer side of the photoelectric sensor 2 in a surrounding mode can block light signals emitted by the photoelectric sensor 2 and scattered outwards, and the fact that the detection result of the nearby photoelectric fusion brain electrode is affected due to the fact that the light signals are scattered into the nearby photoelectric fusion brain electrode is avoided.
It is to be understood that the invention is not limited in its application to the examples described above, but is capable of modification and variation in light of the above teachings by those skilled in the art, and that all such modifications and variations are intended to be included within the scope of the appended claims.

Claims (6)

1. The photoelectric fusion type brain electrode is characterized by comprising an electrode body (1), wherein a photoelectric sensor (2) which is positioned in the middle of the electrode body and is based on photoplethysmography is arranged on the electrode body (1), and an electrode assembly (3) which surrounds the outer side of the photoelectric sensor (2) is also arranged on the electrode body (1); the middle part of the electrode body (1) is provided with a groove (11) for installing the photoelectric sensor (2), and the electrode assembly (3) is positioned outside the groove (11);
the electrode assembly (3) comprises more than two electrode probes with equal-distance circumferential arrays, and the electrode probes adjacent to the two electrode probes are arranged in a staggered manner;
The electrode probe is in a round table shape;
the photoelectric fusion brain electrode is installed by pulling out the head hair of a human body based on the electrode probe.
2. The photoelectric fusion brain electrode according to claim 1, wherein the photoelectric sensor (2) comprises a plurality of LED light sources (21) which are arranged side by side and are used for emitting light signals, and a detector (22) which is arranged on one side of the LED light sources (21) and is used for receiving reflected light signals.
3. The photoelectric fusion brain electrode according to claim 2, wherein the LED light sources (21) are three and emit green light, red light and infrared light, respectively.
4. The photoelectric fusion brain electrode according to claim 2, wherein the LED light source (21) and the detector (22) are located on both sides of the center of the electrode body (1), respectively.
5. The photoelectric fusion brain electrode according to claim 1, wherein the electrode body (1) is cylindrical, and the axis line of the electrode body coincides with the axis of the electrode probe array.
6. The photoelectric fusion brain electrode according to any one of claims 1 to 5, wherein the electrode probe is a microneedle electrode.
CN202110377279.5A 2021-04-08 2021-04-08 Photoelectric fusion type brain electrode Active CN113069120B (en)

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CN115919279A (en) * 2023-01-13 2023-04-07 中国医学科学院北京协和医院 Non-invasive cerebral blood flow monitoring device and method based on photoplethysmography technology

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WO2016021845A1 (en) * 2014-08-08 2016-02-11 최상식 Head mount type device for managing user's state and method for managing user's state
CN204181624U (en) * 2014-09-18 2015-03-04 中国科学院自动化研究所 The helmet of photoelectric synchronous cerebral function imaging instrument and use thereof
CN204863140U (en) * 2015-01-26 2015-12-16 周常安 Er daishi physiology detection device
CN105380623A (en) * 2015-12-11 2016-03-09 吉林大学 Device used for detecting cerebral blood flow and electroencephalogram under epileptics state
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