CN204181624U - The helmet of photoelectric synchronous cerebral function imaging instrument and use thereof - Google Patents
The helmet of photoelectric synchronous cerebral function imaging instrument and use thereof Download PDFInfo
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- CN204181624U CN204181624U CN201420536387.8U CN201420536387U CN204181624U CN 204181624 U CN204181624 U CN 204181624U CN 201420536387 U CN201420536387 U CN 201420536387U CN 204181624 U CN204181624 U CN 204181624U
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Abstract
A helmet for applicable photoelectric synchronous cerebral function imaging, is covered in brain by one or more pieces and makes with the flexible material that brain curvature matches, for synchronous detecting cortex electrical activity and the activity of blood oxygen.Every sheet material profile is octagon, it is placed with the through hole of specific distribution, and electrode for encephalograms, LASER Light Source probe and laser pick-off probe are plugged in through hole removably.Under optimal design, devise 8 LASER Light Source probes and 1 laser pick-off probe in octagon overlay area, 8 light sense channels can be formed; Have also been devised 8 brain electro-detection electrodes, with light sense channel position one_to_one corresponding, form 8 photoelectric synchronous sense channels.This utility model farthest improves the dense degree of sense channel on the minimum basis of testing cost, and each sense channel makes photosignal one_to_one corresponding, for research Electrophysiology relation that the is movable and activity of blood oxygen provides abundant information.
Description
Technical field
This utility model relates to technical field of medical equipment, more specifically, relates to the photoelectric synchronous cerebral function imaging technology in a kind of medical imaging field, the helmet of especially a kind of photoelectric synchronous cerebral function imaging instrument and use thereof.
Background technology
Cerebration comprises multiple process such as neuron activity and local energy metabolism.Researcher is explored brain function by observing the cerebration signal of multiple modalities, and wherein most is representational is the information that neuronic electrical activity and local blood oxygen metabolism change two kinds of mode.Since nearly half a century, the research in a large number based on single modal information has promoted the understanding of people to brain function deeply.But as the different angles of cerebration, only have the effective integration realized different modalities information, cerebration organically could be connected.At present Electrophysiology equipment and metabolic process checkout equipment are combined, make full use of both advantages, become depth finding and understood the important channel of nerve information.
Photoelectric synchronous cerebral function imaging instrument a kind ofly to research and develop, be intended to by the effective integration by function near-infrared spectrum technique and brain wave acquisition technology, same instrument realizes the instrument of near infrared spectrometer, electroencephalograph and near infrared spectrum and brain electro' asion instrument three function integrations.It can realize the several functions such as the synchronous acquisition of the neuroelectricity activity of brain district and blood oxygen information provision, will be the important imaging technique of control fusion cranial nerve electrical activity and the activity of blood oxygen.
At present, although more existing research and utilizations are brain electricity and near infrared imaging system independently, by the electrode in brain electricity and the simple cross arrangement of the auroral poles near infrared imaging in a certain brain district, realize photoelectric synchronous cerebral function imaging, but there are some problems that can not be ignored in the arrangement mode that these researchs adopt.First, great majority research only places electrode for encephalograms in minority near infrared light channel range.The photoelectric synchronous that such as Shimadzu Corporation produces detects the helmet totally 103 optical channels, but 32 electrode for encephalograms are only had, real photoelectric synchronous detects to have the region more than 2/3rds not accomplish, such imaging mode is unfavorable for carrying out the movable and blood oxygen information provision control fusion of neuroelectricity in each brain district, is only a kind of half-way house under limited image-forming condition.Secondly, great majority research is at present the specificity arrangement carried out according to specific requirement of experiment, and its arrangement mode cannot be generalized to the observation in other brain districts, also cannot be generalized to the research under other experiment purposes; And repeatability between different experiments room is poor, is unfavorable for verifying the repeatability of result of study.Therefore be not suitable as the propagable helmet to use.In addition, light source probe and light-receiving to be popped one's head in cross arrangement according to matrix form by existing near infrared imaging mostly, and the number that required light source probe and light-receiving are popped one's head in matches substantially.And the cost of light detection device is much larger than light source discharger, if therefore can reduce light-receiving probe number on this constant basis of optical channel base as far as possible, its cost is by the cost much smaller than current existing arrangement mode.
Summary of the invention
For the problems referred to above, the purpose of this utility model is to provide the helmet of a kind of photoelectric synchronous cerebral function imaging instrument and use thereof, both the demand to brain electricity and the movable one_to_one corresponding synchronous detecting of blood oxygen within the scope of specific brain regions district can have been met, there is good versatility and expansibility, as far as possible few light detection probe number can be adopted again, reduce experimental cost.
In order to achieve the above object, as an aspect of the present utility model, this utility model provides a kind of helmet being suitable for photoelectric synchronous cerebral function imaging, it is characterized in that, is covered in brain and makes with the flexible material that brain curvature matches by one or more pieces; And
The described helmet is placed with for pop one's head in electrode for encephalograms, LASER Light Source and/or laser pick-off is popped one's head in the multiple through holes be connected removably.
Wherein, described in every sheet, the profile of flexible material is octagon.
Wherein, flexible material described in every sheet is placed with for pop one's head in 8 electrode for encephalograms, 8 LASER Light Sources and 1 laser pick-off is popped one's head in 17 through holes be connected removably.
Wherein, the concrete arrangement mode of described through hole is:
For patching 8 through holes of described LASER Light Source probe, arrange in the mode of octagon;
For patching 1 through hole of described laser pick-off probe, be positioned at the center of described octagon; And
For patching 8 through holes of electrode for encephalograms, in square arrangement, described 8 through holes lay respectively at the midpoint of described foursquare summit and each length of side, also be positioned on the connecting line at described octagon eight summits and center simultaneously, and described square is positioned at the inside of described octagon, the center superposition of center and described octagon.
Wherein, the foursquare length of side M that the through hole of described 8 grafting electrode for encephalograms surrounds is: 2.7cm≤M≤4.06cm; And
The length of side L of described octagon is: 1.91cm≤L≤3.83cm.
Wherein, by flexible connecting material, the helmet of flexible material described in multi-disc is connected, realizes the expansion of the helmet.
Wherein, described laser is near-infrared laser, and wavelength is between 600nm to 1000nm.
Wherein, the described through hole for inserting light source probe and light-receiving probe can insert the optical fiber of conduction near infrared light.
Wherein, the described through hole for inserting light source probe and light-receiving probe can exchange, and the through hole namely for inserting light source probe patches light-receiving probe, and patches light source probe for the through hole inserting light-receiving probe.
As another aspect of the present utility model, this utility model provides a kind of photoelectric synchronous cerebral function imaging instrument, comprise main frame, the helmet being suitable for photoelectric synchronous cerebral function imaging as above described in any one, and/or electrode for encephalograms, LASER Light Source probe, laser pick-off probe.
Wherein, described in be suitable for photoelectric synchronous cerebral function imaging the helmet on there is multiple through hole for inserting light source probe, the utilizing emitted light of described Different Light probe loads different modulating frequencies and is distinguished.
Known by technique scheme, the helmet of photoelectric synchronous cerebral function imaging instrument of the present utility model and use thereof, owing to adopting octagon and including foursquare configuration of electrodes, not only can realize within the scope of specific brain regions district brain electricity and blood oxygen activity synchronous detecting one to one, there is good versatility and expansibility, as far as possible few light detection probe number can also be adopted, reduce experimental cost; Further, the basis that testing cost is minimum farthest improves the dense degree of sense channel, and each sense channel makes photosignal one_to_one corresponding, for research Electrophysiology relation that the is movable and activity of blood oxygen provides abundant information.
Accompanying drawing explanation
Fig. 1 is the propagation path schematic diagram of near infrared light in cerebral tissue;
Fig. 2 is the configuration of electrodes schematic diagram of international standard " 10-20 ", " 10-10 ", " 10-5 " system;
Fig. 3 is the schematic diagram that octagon of the present utility model is applicable to the arrays of openings position of the helmet of photoelectric synchronous cerebral function imaging;
Fig. 4 is that octagon of the present utility model is applicable to the optical channel of the helmet of photoelectric synchronous cerebral function imaging and the schematic diagram of electrode position;
Fig. 5 is the schematic diagram being positioned at the arrays of openings position of the photoelectric synchronous cerebral function imaging helmet of the present utility model in bilateral movement district as two an of embodiment of the present utility model.
Detailed description of the invention
For making the technical solution of the utility model and applied environment clearly understand, below in conjunction with specific embodiments and the drawings, the utility model is described in further detail.
This experiment new patent is intended to the helmet developing a set of applicable photoelectric synchronous cerebral function imaging, not only can realize within the scope of specific brain regions district brain electricity and blood oxygen activity synchronous detecting one to one, and there is good versatility and expansibility, as far as possible few light detection probe number can also be adopted, reduce experimental cost.
The double requirements of the arrangement of photoelectric synchronous Brian Imaging helmet demand fulfillment near infrared spectrum imaging probe and brain Electrical imaging electrode arrangements, specific as follows:
First, brain blood oxygen based near infrared spectrum is detected, near infrared light (wavelength is the electromagnetic wave of 600 to 1000nm) incides cerebral tissue by transmitting probe through scalp surface, through absorption and each histiocytic scattering of the material such as hemoglobin, deoxyhemoglobin, the optical channel forming " banana-shaped " is penetrated by scalp surface, and received probe detects (as shown in Figure 1).Therefore, the surveyed area (i.e. optical channel) of near infrared light is located between light source probe and detection probe, and its propagation path in cerebral tissue and detect the degree of depth and determined by the distance between transmitting probe and receiving transducer.When current researcher generally acknowledges that distance between light source probe and receiving transducer is between 2-5cm optical channel by cerebral tissue and the signal to noise ratio of Received signal strength can accept, for best when being wherein about 3cm.
Secondly, for brain electro-detection, its signal source is the electromagnetic wave that the neuroelectricity activity of brain self produces, and therefore only needs detecting electrode, without the need to the sender unit in the external world.At present, the arrangement mode of the electrode for encephalograms of generally acknowledging in the world is " 10-20 ", " 10-10 ", " 10-5 " system (as shown in Figure 2).They are all a series of space point sets in scalp surface, its locus is fixed really, is according to two markings in length and breadth: from nose recessed through the crown to the vertical line of occipital protuberance with from the horizontal line of left ear external auditory meatus through the crown to auris dextra external auditory meatus, the length of two markings is carried out decile according to 20%, 10% or 5%, crisscrossly subsequently determines the equally distributed serial point set of full brain.The spacing being uniformly distributed the consecutive points referring to all directions is basically identical.The full brain of " 10-5 " system can reach 345 points, and wherein a part of subset constitutes the position of 128 general at present passage EEG electrode arrangements.Due to the various point locations that this system is by determining the decile of scalp surface two markings in length and breadth, adjacent point-to-point transmission spacing is relevant with head part's size.According to statistics, child is 40-65cm to the head circumference of adult, and the recessed vertical connecting line to occipital protuberance of nose is 27-37.8cm, and the horizontal connection line length between two ears is 30.5-40.5cm.Therefore can estimate spacing between adjacent 2 of " 10-5 " system and be about 1.35cm to 2.03cm.
The shape of the helmet of the applicable photoelectric synchronous cerebral function imaging designed by this utility model is not limit, but requires the region comprising octagon, and the shape of the preferred helmet is octagon.Including octagon center to the distance of drift angle is arbitrary value from 2.5cm to 5cm, and the length of side of corresponding octagon changes between scope from 1.91cm to 3.83cm.As shown in Figure 3, represent the distance of octagon center to drift angle with lower part A herein, represent the length of side of octagon with L.L and A has following relation: L=cos (67.5 °) × 2 × A=0.7654 × A.Octagon inside has with 8 through holes of square shape arrangement, and this foursquare length of side is the arbitrary value from 2.7cm to 4.06cm.The foursquare length of side is represented herein with lower part M.
17 through holes are had in octagon, wherein 8 through holes at octagonal drift angle place can insert light source transmitting probe, 1 through hole at octagon center can insert light detection probe, as shown in Figure 4, can form an optical channel between each light source transmitting probe and light detection probe.The drift angle of inner square and the midpoint on limit have 8 through holes, can insert brain electro-detection electrode.As shown in Figure 4, the position of electrode for encephalograms all overlaps with optical channel position.
Under optimal design, 8 drift angles of octagon lay 8 near infrared light light source probes, and each probe can the near infrared light of the two or more specific wavelengths of emission wavelength between 600nm to 1000nm.The utilizing emitted light of different transmitting probe loads different modulating frequencies and is distinguished.1 near infrared light receiving transducer is laid at the center of octagon, can receive the optical signal of all transmitting probes, and passes through the mode of numeral or analog demodulator according to the modulating frequency of different transmitting illuminant, obtains the signal from each transmitting probe.Therefore, 8 optical channels not exclusively overlapped can be had in the coverage of octagon.
The electrode for encephalograms lead to the hole site of the described octagon photoelectric synchronous cerebral function imaging helmet is positioned at octagon inside, square arrangement.The center superposition of its center and octagon, its four summits and four length of side mid points are all positioned on the connecting line at octagon summit and center; Its half length of side M/2 is 1.35cm to 2.03cm, and length of side M is 2.7cm to 4.06cm.Under optimal design, foursquare four summits and four length of side mid points all insert electrode for encephalograms, with eight optical channel one_to_one corresponding of near infrared imaging, form eight photoelectric synchronous detecting units.Under this design, as long as suitably adjust octagonal placement location, electrode position will meet international " 10-5 " system standard substantially.
The described helmet being suitable for photoelectric synchronous cerebral function imaging, for inserting the through hole of light source probe and light-receiving probe, maybe can insert the optical fiber of conduction near infrared light.
The described helmet being suitable for photoelectric synchronous cerebral function imaging, for inserting the through hole of light source probe and light-receiving probe, under experiment condition allows, or interchangeable, namely octagon central through hole patches light source probe, and octagon corner position through hole patches light-receiving probe.Specific design scheme of the present utility model is introduced below by specific embodiment.
The cerebration of the present embodiment planning studies adult sensorimotor system.Because adult's head circumference is about 54cm to 58cm, the average length of the recessed horizontal markings through the crown to the vertical markings of occipital protuberance and both sides external auditory meatus line of nose is 37cm, and in " 10-5 " system, electrode spacing is about 5% of markings length.Therefore estimate that M/2 is about 37*5%=1.85cm, i.e. M=3.7cm.Specify A=3cm, L=2.3cm.
Because sensorimotor symmetry system having symmetry is distributed in brain both sides, position mainly in " 10-5 " system left side C1, C3 and right side C2, C4 near.Therefore the present embodiment plan adopts two octagon photoelectric synchronous record helmets, it is placed on sensorimotor area, left and right respectively, utilizes flexible material the helmet is fixed on head and ensures position stability.Specifically as shown in Figure 5.Wherein the center (i.e. light detection probe d1) of left side octagon is between C1 and C3, and electrode e1 to e8 is corresponding FCC3, FCC3h, FCC1, C1, CCP1, CCP3h, CCP3 and C3 position respectively.The center (i.e. light detection probe d2) of right side octagon is between C2 and C4, and electrode e9 to e16 is corresponding FCC2, FCC4h, FCC4, C4, CCP4, CCP4h, CCP2 and C2 position respectively.This electrode group is contained substantially at present based on the electrode position paid close attention to main in the sensorimotor task study of EEG, meets requirement of experiment.Answer with each electrode pair, the helmet periphery vertex position of two octagons all inserts light source probe s1 to s16, forms 16 and each electrode for encephalograms optical channel one to one, movable for the blood oxygen detecting bilateral sensorimotor system.Thus realize photoelectric synchronous cerebral function imaging.
As shown in Figure 5, the helmet of the present utility model such as can pass through two-point locating (C1 and C3, or C2 and C4), by " 10-20 ", " 10-10 " or " 10-5 " system point that two through-hole alignment heads are corresponding, can by the described helmet at head location.Then, by flexible material, the described helmet can be fixed on the relevant position of head, realize the Photoelectric Detection of head specific region.In order to save time, as shown in Figure 5, flexible connecting material can also be utilized to be connected by more sheets, to realize the expansion of the helmet, thus realize the simultaneous observation in Duo Nao district.
Finally it should be noted that above implementation content is only the use of special process for citing, in fact can change wherein process, under the condition not departing from this utility model design, all within protection domain of the present utility model.
Claims (10)
1. be suitable for a helmet for photoelectric synchronous cerebral function imaging, it is characterized in that, be covered in brain by one or more pieces and make with the flexible material that brain curvature matches; And
The described helmet is placed with for pop one's head in electrode for encephalograms, LASER Light Source and/or laser pick-off is popped one's head in the multiple through holes be connected removably.
2. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 1, wherein described in every sheet, the profile of flexible material is octagon.
3. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 1, wherein flexible material described in every sheet is placed with for pop one's head in 8 electrode for encephalograms, 8 LASER Light Sources and 1 laser pick-off is popped one's head in 17 through holes be connected removably.
4. the helmet being applicable to photoelectric synchronous cerebral function imaging according to claim 3, the concrete arrangement mode of wherein said through hole is:
For patching 8 through holes of described LASER Light Source probe, arrange in the mode of octagon;
For patching 1 through hole of described laser pick-off probe, be positioned at the center of described octagon; And
For patching 8 through holes of electrode for encephalograms, in square arrangement, described 8 through holes lay respectively at the midpoint of described foursquare summit and each length of side, also be positioned on the connecting line at described octagon eight summits and center simultaneously, and described square is positioned at the inside of described octagon, the center superposition of center and described octagon.
5. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 4, the foursquare length of side M that the through hole of wherein said 8 grafting electrode for encephalograms surrounds is: 2.7cm≤M≤4.06cm; And
The length of side L of described octagon is: 1.91cm≤L≤3.83cm.
6. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 1, is wherein connected the helmet of flexible material described in multi-disc by flexible connecting material, realizes the expansion of the helmet.
7. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 1, wherein said laser is near-infrared laser, and wavelength is between 600nm to 1000nm.
8. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 1, the wherein said through hole for inserting light source probe and light-receiving probe can insert the optical fiber of conduction near infrared light.
9. the helmet being suitable for photoelectric synchronous cerebral function imaging according to claim 1, the wherein said through hole for inserting light source probe and light-receiving probe can exchange, namely the through hole for inserting light source probe patches light-receiving probe, and patches light source probe for the through hole inserting light-receiving probe.
10. a photoelectric synchronous cerebral function imaging instrument, comprises main frame, is suitable for the helmet of photoelectric synchronous cerebral function imaging as in one of claimed in any of claims 1 to 9, and/or electrode for encephalograms, LASER Light Source probe, laser pick-off probe.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106236085A (en) * | 2016-09-26 | 2016-12-21 | 中国医学科学院生物医学工程研究所 | For detecting generating means and the detection method of NEG cerebration instrument synchronicity |
| CN107865635A (en) * | 2016-09-28 | 2018-04-03 | 首都儿科研究所 | A kind of combined sensor |
| CN109843154A (en) * | 2016-08-19 | 2019-06-04 | 高尔实验室有限公司 | For measuring the measuring device and equipment of the change of chromophore concentration |
| CN111227790A (en) * | 2020-01-08 | 2020-06-05 | 北京师范大学 | Near-infrared probe arrangement method based on brain functional region positioning and head cap |
| CN111466922A (en) * | 2020-05-14 | 2020-07-31 | 中科搏锐（北京）科技有限公司 | Adaptive blood oxygen signal acquisition probe, device and method based on near infrared blood oxygen detection |
| CN111714119A (en) * | 2020-06-28 | 2020-09-29 | 清华大学 | Non-invasive shapeable bimodal brain-computer interface |
| CN112674718A (en) * | 2020-12-01 | 2021-04-20 | 浙江清华柔性电子技术研究院 | Brain imaging detection device |
| CN113069120A (en) * | 2021-04-08 | 2021-07-06 | 季华实验室 | Photoelectric fusion type brain electrode |
| CN113951833A (en) * | 2021-11-29 | 2022-01-21 | 武汉资联虹康科技股份有限公司 | Channel pluggable portable near-infrared brain function imaging system and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109843154A (en) * | 2016-08-19 | 2019-06-04 | 高尔实验室有限公司 | For measuring the measuring device and equipment of the change of chromophore concentration |
| CN106236085A (en) * | 2016-09-26 | 2016-12-21 | 中国医学科学院生物医学工程研究所 | For detecting generating means and the detection method of NEG cerebration instrument synchronicity |
| CN107865635A (en) * | 2016-09-28 | 2018-04-03 | 首都儿科研究所 | A kind of combined sensor |
| CN111227790A (en) * | 2020-01-08 | 2020-06-05 | 北京师范大学 | Near-infrared probe arrangement method based on brain functional region positioning and head cap |
| CN111466922A (en) * | 2020-05-14 | 2020-07-31 | 中科搏锐（北京）科技有限公司 | Adaptive blood oxygen signal acquisition probe, device and method based on near infrared blood oxygen detection |
| CN111466922B (en) * | 2020-05-14 | 2023-11-24 | 中科搏锐（北京）科技有限公司 | Self-adaptive blood oxygen signal acquisition probe, device and method based on near infrared blood oxygen detection |
| CN111714119A (en) * | 2020-06-28 | 2020-09-29 | 清华大学 | Non-invasive shapeable bimodal brain-computer interface |
| CN111714119B (en) * | 2020-06-28 | 2022-01-04 | 清华大学 | Non-invasive shapeable bimodal brain-computer interface |
| CN112674718A (en) * | 2020-12-01 | 2021-04-20 | 浙江清华柔性电子技术研究院 | Brain imaging detection device |
| CN113069120A (en) * | 2021-04-08 | 2021-07-06 | 季华实验室 | Photoelectric fusion type brain electrode |
| CN113951833A (en) * | 2021-11-29 | 2022-01-21 | 武汉资联虹康科技股份有限公司 | Channel pluggable portable near-infrared brain function imaging system and method |
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