CN113057244A - Preparation process of tablet candy with immunoregulation effect - Google Patents
Preparation process of tablet candy with immunoregulation effect Download PDFInfo
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- CN113057244A CN113057244A CN202110471927.3A CN202110471927A CN113057244A CN 113057244 A CN113057244 A CN 113057244A CN 202110471927 A CN202110471927 A CN 202110471927A CN 113057244 A CN113057244 A CN 113057244A
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- tabletting
- leaching
- enzymolysis
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of food processing, and particularly relates to a preparation process of a tablet candy with an immunoregulation effect. The preparation process of the pressed candy comprises the following steps: s1: pulverizing the raw materials, and sieving; the raw materials are as follows: ginseng, angelica, yam, lily, jujube and tuckahoe; s2: adding compound enzyme into the raw material sieved in the S1 for enzymolysis, and inactivating enzyme; s3: carrying out solid-liquid separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution; s4: and (4) concentrating the leaching liquor in the S3 and the supernatant obtained by solid-liquid separation into thick paste, adding a sweetening agent and auxiliary materials, uniformly mixing, granulating and tabletting to obtain the tablet candy. The invention has the beneficial effects that: (1) extracting active ingredients in the raw materials by adopting an enzymolysis mode, and fully dissolving out the active ingredients to ensure that the final product has higher active ingredient content; (2) compared with the alcohol precipitation method, the method of the invention does not consume organic solvent, is environment-friendly and has mild preparation conditions.
Description
Technical Field
The invention belongs to the technical field of food processing, and particularly relates to a preparation process of a tablet candy with an immunoregulation effect.
Background
As for documents having an immunomodulatory effect, the following patent applications are disclosed:
CN112375157A proposes a codonopsis pilosula glucan with immunoregulation effect, which is characterized in that: the codonopsis pilosula glucan is formed by connecting alpha-D-glucopyranose 1 → 4 glycosidic bonds in a main chain and is formed by connecting beta-D-glucopyranose 6 → 1 glycosidic bonds in a branched chain. The method comprises the following steps: (1) extracting codonopsis pilosula polysaccharide, soaking the codonopsis pilosula medicinal material for 30min according to the material-liquid ratio of 1: 10-1: 20, heating and refluxing for extraction for 3 times, wherein each time lasts for 1.5h, and combining three extracting solutions; (2) alcohol precipitation of the codonopsis pilosula polysaccharide, namely, decompressing and concentrating a codonopsis pilosula polysaccharide extracting solution to 1/4-1/3 volume, adopting 60-90% ethanol for precipitation, centrifuging for 15-30 min at 1000-1500 rpm, removing supernatant, washing precipitates for 3 times by using diethyl ether, ethyl acetate, acetone and absolute ethyl alcohol in sequence, and freeze-drying to obtain a codonopsis pilosula polysaccharide sample; (3) and carrying out ultrafiltration separation on the codonopsis pilosula polysaccharide, dissolving the codonopsis pilosula polysaccharide sample by using water, and finally filtering the dissolved codonopsis pilosula polysaccharide sample by using a filter membrane with a molecular weight of 3000 to obtain the codonopsis pilosula glucan with the immunoregulation effect.
The codonopsis pilosula glucan adopts an ultrafiltration method in the preparation process, the ultrafiltration cost is high, an alcohol precipitation method is also adopted in the preparation process, and the method consumes a large amount of organic solvents and is not environment-friendly.
Therefore, there is a need for improvement over the above-mentioned methods, and to invent a method for preparing a tabletted confectionery that is mild in preparation conditions and relatively low in cost.
Disclosure of Invention
In order to solve the technical problems, the invention provides a preparation method of the tabletted candy with mild preparation conditions and relatively low cost.
A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the raw materials are as follows: ginseng, angelica, yam, lily, jujube and tuckahoe;
s2: adding compound enzyme into the raw material sieved in the S1 for enzymolysis, and inactivating enzyme;
s3: carrying out solid-liquid separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: and (4) concentrating the leaching liquor in the S3 and the supernatant obtained by solid-liquid separation into thick paste, adding a sweetening agent and auxiliary materials, uniformly mixing, granulating and tabletting to obtain the tablet candy.
The weight parts of the raw materials are as follows: 10-15 parts of ginseng, 10-15 parts of angelica, 20-30 parts of Chinese yam, 40-50 parts of lily, 10-15 parts of Chinese date and 10-15 parts of tuckahoe.
Preferably, in S1, the raw material is pulverized and sieved through a 60-mesh sieve.
Preferably, in S2, the complex enzyme is acidic cellulase and acidic pectinase, and the weight ratio of the acidic cellulase to the acidic pectinase is 0.8-1.2: 1.
preferably, in S2, the adding amount of the acidic cellulase and the acidic pectinase is 1-2% of the total weight of the raw materials.
Preferably, when the compound enzyme in the S2 is used for enzymolysis, water is added, and the weight ratio of the raw materials to the water is 1: 7-11; adjusting the pH value to 4.5-5.0, and carrying out enzymolysis for 50-70 min at the temperature of 40-50 ℃.
Preferably, the solid-liquid separation method in S3 is centrifugal separation.
Preferably, in S3, the water decoction and extraction of the solid residue comprises the following steps: adding water with the weight 8-10 times of that of the decoction dregs into the decoction dregs, leaching for 15-30 min in boiling water, and centrifuging for 10-15 min at the rotating speed of 4000-5000 r/min.
Preferably, in S4, the leaching liquor and the supernatant are concentrated to 10-15% of the total volume of the leaching liquor and the supernatant, and leaching paste is obtained;
in S4, the auxiliary materials are as follows: weighing 30-50 parts of corn starch, 5-10 parts of magnesium stearate, 5-10 parts of microcrystalline cellulose, 15-20 parts of dextrin, 20-30 parts of sucrose and 5-10 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 30-40% of the total weight of the raw materials, and during granulation, the raw materials are dried at 80 ℃ until the water content is below 5%;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
Preferably, the preparation process of the tabletted candy with the immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 10-15 parts of ginseng, 10-15 parts of angelica, 20-30 parts of Chinese yam, 40-50 parts of lily, 10-15 parts of Chinese date and 10-15 parts of tuckahoe;
s2: adding a compound enzyme consisting of acid cellulase and acid pectinase into the raw material sieved in the S1 for enzymolysis, and inactivating the enzyme for 5-15 min at 95 ℃;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching liquor and the supernatant liquor in the S3 to 10-15% of the total volume of the leaching liquor and the supernatant liquor to obtain leaching paste, adding a sweetening agent and auxiliary materials, uniformly mixing, granulating and tabletting to obtain tabletting candies;
the preparation method of the auxiliary materials comprises the following steps: weighing 30-50 parts of corn starch, 5-10 parts of magnesium stearate, 5-10 parts of microcrystalline cellulose, 15-20 parts of dextrin, 20-30 parts of cane sugar and 5-10 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 30-40% of the total weight of the raw materials, and during granulation, the raw materials are dried at 80 ℃ until the water content is below 5%;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
The invention has the beneficial effects that:
(1) in the invention, the active ingredients in the raw materials are extracted by adopting an enzymolysis mode, so that the active ingredients are fully dissolved out, and the content of the active ingredients in the final product is higher;
(2) compared with the alcohol precipitation method, the method of the invention does not consume organic solvent, is environment-friendly and has mild preparation conditions.
Drawings
FIG. 1 is a flow chart of the process for preparing the tabletted candy according to the present invention.
Detailed Description
The present invention will now be further described with reference to specific embodiments in order to enable those skilled in the art to better understand the present invention.
Example 1
A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 12 parts of ginseng, 12 parts of angelica, 25 parts of yam, 45 parts of lily, 13 parts of jujube and 13 parts of tuckahoe;
s2: adding complex enzyme composed of acidic cellulase and acidic pectinase into the sieved raw material in S1 for enzymolysis, and inactivating enzyme at 95 deg.C for 10 min;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching liquor and the supernatant liquor in the S3 to 13% of the total volume of the leaching liquor and the supernatant liquor to obtain leaching paste, adding a sweetening agent xylitol and auxiliary materials, uniformly mixing, granulating and tabletting to obtain tablet candy; the sweetener accounts for 8% of the total weight of the tabletted candy;
the preparation method of the auxiliary materials comprises the following steps: weighing 40 parts of corn starch, 8 parts of magnesium stearate, 8 parts of microcrystalline cellulose, 18 parts of dextrin, 25 parts of sucrose and 8 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 35 percent of the total weight of the raw materials, and are dried at 80 ℃ until the water content is less than 5 percent during granulation;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
Example 2
A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 12 parts of ginseng, 12 parts of angelica, 23 parts of yam, 43 parts of lily, 12 parts of Chinese date and 12 parts of tuckahoe;
s2: adding complex enzyme composed of acidic cellulase and acidic pectinase into the sieved raw material in S1 for enzymolysis, and inactivating enzyme at 95 deg.C for 7 min;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching liquor and the supernatant liquor in the S3 to 13% of the total volume of the leaching liquor and the supernatant liquor to obtain leaching paste, adding the sweetener stevioside and the auxiliary materials, uniformly mixing, granulating and tabletting to obtain the tablet candy; stevioside accounts for 8% of the total weight of the tabletted candy;
the preparation method of the auxiliary materials comprises the following steps: weighing 38 parts of corn starch, 7 parts of magnesium stearate, 7 parts of microcrystalline cellulose, 17 parts of dextrin, 23 parts of sucrose and 7 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 33 percent of the total weight of the raw materials, and are dried at 80 ℃ until the water content is less than 5 percent during granulation;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
Example 3
A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 10 parts of ginseng, 10 parts of angelica, 20 parts of Chinese yam, 40 parts of lily, 10 parts of Chinese date and 10 parts of tuckahoe;
s2: adding complex enzyme composed of acidic cellulase and acidic pectinase into the sieved raw material in S1 for enzymolysis, and inactivating enzyme at 95 deg.C for 5 min;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching liquor and the supernatant liquor in the S3 to 10% of the total volume of the leaching liquor and the supernatant liquor to obtain leaching paste, adding the sweetener xylitol and the auxiliary materials, uniformly mixing, granulating and tabletting to obtain the tablet candy; xylitol accounts for 10% of the total weight of the tabletted candy;
the preparation method of the auxiliary materials comprises the following steps: weighing 30 parts of corn starch, 5 parts of magnesium stearate, 5 parts of microcrystalline cellulose, 15 parts of dextrin, 20 parts of sucrose and 5 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 30 percent of the total weight of the raw materials, and are dried at 80 ℃ until the water content is less than 5 percent during granulation;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
Example 4
A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 15 parts of ginseng, 15 parts of angelica, 30 parts of Chinese yam, 50 parts of lily, 15 parts of Chinese date and 15 parts of tuckahoe;
s2: adding complex enzyme composed of acidic cellulase and acidic pectinase into the sieved raw material in S1 for enzymolysis, and inactivating enzyme at 95 deg.C for 15 min;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching liquor and the supernatant liquor in the S3 to 15% of the total volume of the leaching liquor and the supernatant liquor to obtain leaching paste, adding the sweetening agent aspartame and auxiliary materials, uniformly mixing, granulating and tabletting to obtain tablet candy; aspartame accounts for 9% of the total weight of the tabletted candy;
the preparation method of the auxiliary materials comprises the following steps: weighing 50 parts of corn starch, 10 parts of magnesium stearate, 10 parts of microcrystalline cellulose, 20 parts of dextrin, 30 parts of sucrose and 10 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 40 percent of the total weight of the raw materials, and are dried at 80 ℃ until the water content is less than 5 percent during granulation;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
Example 5
A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 10-15 parts of ginseng, 14 parts of angelica, 27 parts of Chinese yam, 47 parts of lily, 14 parts of Chinese date and 14 parts of tuckahoe;
s2: adding complex enzyme composed of acidic cellulase and acidic pectinase into the sieved raw material in S1 for enzymolysis, and inactivating enzyme at 95 deg.C for 12 min;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching solution and the supernatant in the S3 to 14% of the total volume of the leaching solution and the supernatant to obtain leaching paste, adding the sweetening agent disodium glycyrrhizinate and the auxiliary materials, uniformly mixing, granulating and tabletting to obtain tabletting candies; the disodium glycyrrhizinate accounts for 10% of the total weight of the tabletted candy;
the preparation method of the auxiliary materials comprises the following steps: weighing 42 parts of corn starch, 9 parts of magnesium stearate, 9 parts of microcrystalline cellulose, 19 parts of dextrin, 27 parts of sucrose and 9 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 37 percent of the total weight of the raw materials, and are dried at 80 ℃ until the water content is less than 5 percent during granulation;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
Example 6
In order to verify the immunomodulatory efficacy of the tabletted confectioneries obtained in the present invention, the inventors carried out the following experiments:
materials: LPS (LPS, from E.coli 055: B5)), lipopolysaccharide, Shanghai Rinshu Biotech Co., Ltd;
PHA: phytohemagglutinin, shanghai ihua corporation, dry powder;
RPMI1640 culture solution: manufactured by Hyclone corporation;
the method comprises the following steps:
6.1 analysis of separation of Peripheral Blood Mononuclear Cells (PBMC) from the tabletted sweetmeat of example 1, the procedure used was as follows:
HES centrifugal separation;
materials: taking 10 parts of peripheral blood; 6% HES (hydroxyethyl starch) commercially available;
diluting heparin anticoagulated whole blood by RPMI1640 according to the proportion of 1:1, performing gradient centrifugation with a Ficoll lymphocyte separation solution with the volume of 2:1, and separating PBMC;
the cell number was adjusted to 2X 10 in RPMI1640 medium containing 1% L-glu-tamine and 10% autologous plasma6Per ml, 2X 10 of 0.1ml per well6The inhibition of TNF-alpha and TGF-beta by the tabletted sweetmeats was examined in 96-well plates with PBMC at ml.
The method for separating the mononuclear cells by adopting an adsorption method comprises the following specific steps: PBMC were adjusted to 10 in RPMI1640 medium without autologous plasma7Adding into culture flask at 37 deg.C with 5% CO2Culturing for 2 hours, absorbing culture supernatant containing non-adherent cells, washing with Hanks liquid for 2 times, adding Trypsin-0.05EDTA, standing at 4 deg.C for 15 minutes, and collecting mononuclear cells.
Pretreatment experiments of tabletted confections with PBMC and monocytes were performed in RPMI1640 medium containing 1% L-glu-tamine, 10% autologous plasma.
1. mu.g/ml LPS (LPS, from E.Coli 055: B5)) and 1. mu.g/ml PHA were used to induce TNF-. alpha.and TGF-. beta.respectively.
PBMC (2X 10 concentration) was added at 100. mu.g/ml per well in 96-well plates6Per ml), 50. mu.g of different concentrations of tabletted candy and 50. mu.l of LPS (1. mu.g/ml), the different concentrations of tabletted candy being: 1ng/ml, 5ng/ml, 10ng/ml, 15ng/ml, 30ng/ml, 50 ng/ml. A positive control group containing 1. mu.g/ml LPS was set for each reaction, a 20ng/ml tabletted candy group, a blank control group without any inducer were also set, and the three groups were incubated in parallel for 24 hours. The tabletted confectioneries were then observed for inhibition of lipopolysaccharide LPS-induced TNF- α.
When observing the inhibition of the tabletting candies on the TGF-beta induced by the phytohemagglutinin PHA, selecting different concentrations of the tabletting candies to be co-cultured with 5 mu g/ml of LPHA, wherein the concentrations of the different concentrations of the tabletting candies are as follows: 1ng/ml, 5ng/ml, 10ng/ml, 15ng/ml and 40 ng/ml; and a positive group and a blank control group were set, and both groups were cultured in parallel for 6 days. The cultured supernatant was collected and the production levels of TNF-. alpha.and TGF-. beta.were measured by ELISA.
2. Immunophenotyping, in which the source of TNF-alpha producing cells is analyzed by using the immunophenotyping of a flow cytometer when the culture of the PBMC pretreatment test is stopped, the difference of the number of the TNF-alpha producing cells and the inhibition of the tabletting candy on the TNF-alpha are compared, and an undyed group and an isotype control dyed group are respectively arranged.
Calculation of TNF-alpha and TGF-beta inhibition:
inhibition rate ═ 1- (tripterygium wilfordii + cleavage source experimental wells)/cleavage source control wells ] x 100%.
The results are as follows:
TABLE 1 ELISA test of the Effect of different concentrations of tabletted sweets on TNF- α production after pretreatment of monocytes
Note: the above 1, 2 and 3 represent the results of the parallel experiments, respectively.
TABLE 2 ELISA test of TGF-beta inhibition of different concentrations of tabletted sweets after pretreatment of monocytes
Note: the above 1, 2 and 3 represent the results of the parallel experiments, respectively.
Through the above experiments, it was confirmed that the tabletted confectionery of the present invention can inhibit the production of TNF-. alpha.and TGF-. beta.by LPS induced PBMCs of healthy humans and is also affected by the dose. This shows that the tabletted sweetmeat of the present invention has an immunomodulating effect and also has a certain anti-inflammatory effect.
Claims (10)
1. A preparation process of a tablet candy with an immunoregulation effect comprises the following steps:
s1: pulverizing the raw materials, and sieving; the raw materials are as follows: ginseng, angelica, yam, lily, jujube and tuckahoe;
s2: adding compound enzyme into the raw material sieved in the S1 for enzymolysis, and inactivating enzyme;
s3: carrying out solid-liquid separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: and (4) concentrating the leaching liquor in the S3 and the supernatant obtained by solid-liquid separation into thick paste, adding a sweetening agent and auxiliary materials, uniformly mixing, granulating and tabletting to obtain the tablet candy.
2. The process for preparing a tabletted candy with an immunomodulatory effect as claimed in claim 1, wherein the raw materials are in parts by weight as follows: 10-15 parts of ginseng, 10-15 parts of angelica, 20-30 parts of Chinese yam, 40-50 parts of lily, 10-15 parts of Chinese date and 10-15 parts of tuckahoe.
3. The process for preparing a tabletted candy with an immunomodulatory effect according to claim 1, wherein in S1 the raw materials are crushed and sieved through a 60 mesh sieve.
4. The preparation process of the tabletted candy with the immunoregulation effect as claimed in claim 1, wherein in S2, the complex enzyme is acidic cellulase and acidic pectinase, and the weight ratio of the acidic cellulase to the acidic pectinase is 0.8-1.2: 1.
5. the process for preparing a tabletted candy with an immunomodulatory effect according to claim 1, wherein the acidic cellulase and acidic pectinase are added in an amount of 1-2% by weight of the total weight of the raw materials in S2.
6. The preparation process of the tabletted candy with the immunoregulation effect as claimed in claim 1, wherein water is added during the enzymolysis of the complex enzyme in S2, and the weight ratio of the raw materials to the water is 1: 7-11; adjusting the pH value to 4.5-5.0, and carrying out enzymolysis for 50-70 min at the temperature of 40-50 ℃.
7. The process for preparing a tabletted candy product with an immunomodulatory effect according to claim 1, wherein the solid-liquid separation in S3 is centrifugation.
8. The preparation process of the tabletted candy with the immunoregulation effect according to claim 1, wherein in S3, the specific steps of taking solid medicine residues and decocting and leaching with water are as follows: adding water with the weight 8-10 times of that of the decoction dregs into the decoction dregs, leaching for 15-30 min in boiling water, and centrifuging for 10-15 min at the rotating speed of 4000-5000 r/min.
9. The process for preparing a tabletted candy with an immunomodulatory effect according to claim 1, wherein in S4, the leaching solution and the supernatant are concentrated to 10-15% of the total volume of the two solutions to obtain a leaching paste;
in S4, the auxiliary materials are as follows: weighing 30-50 parts of corn starch, 5-10 parts of magnesium stearate, 5-10 parts of microcrystalline cellulose, 15-20 parts of dextrin, 20-30 parts of sucrose and 5-10 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 30-40% of the total weight of the raw materials, and during granulation, the raw materials are dried at 80 ℃ until the water content is below 5%;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
10. The process for preparing a tabletted candy product with an immunomodulatory effect according to claim 1, comprising the steps of:
s1: pulverizing the raw materials, and sieving; the weight parts of the raw materials are as follows: 10-15 parts of ginseng, 10-15 parts of angelica, 20-30 parts of Chinese yam, 40-50 parts of lily, 10-15 parts of Chinese date and 10-15 parts of tuckahoe;
s2: adding a compound enzyme consisting of acid cellulase and acid pectinase into the raw material sieved in the S1 for enzymolysis, and inactivating the enzyme for 5-15 min at 95 ℃;
s3: carrying out solid-liquid centrifugal separation on the enzymolysis liquid in the S2, and taking solid dregs to decoct and leach to obtain a leaching solution;
s4: concentrating the leaching liquor and the supernatant liquor in the S3 to 10-15% of the total volume of the leaching liquor and the supernatant liquor to obtain leaching paste, adding a sweetening agent and auxiliary materials, uniformly mixing, granulating and tabletting to obtain tabletting candies;
the preparation method of the auxiliary materials comprises the following steps: weighing 30-50 parts of corn starch, 5-10 parts of magnesium stearate, 5-10 parts of microcrystalline cellulose, 15-20 parts of dextrin, 20-30 parts of cane sugar and 5-10 parts of extraction paste, and uniformly mixing;
the auxiliary materials account for 30-40% of the total weight of the raw materials, and during granulation, the raw materials are dried at 80 ℃ until the water content is below 5%;
during tabletting, the materials are poured into a hopper of a tabletting machine, and tabletting and forming are carried out in the environment with room temperature and relative humidity of less than 70 percent.
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| CN115644299A (en) * | 2022-11-03 | 2023-01-31 | 甘肃长征药业集团有限公司 | Radix astragali tablet candy and preparation method thereof |
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