CN113046884B - Antibacterial degradable medical suture - Google Patents
Antibacterial degradable medical suture Download PDFInfo
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- CN113046884B CN113046884B CN202110322424.XA CN202110322424A CN113046884B CN 113046884 B CN113046884 B CN 113046884B CN 202110322424 A CN202110322424 A CN 202110322424A CN 113046884 B CN113046884 B CN 113046884B
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Classifications
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- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/449—Yarns or threads with antibacterial properties
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
- D02G3/04—Blended or other yarns or threads containing components made from different materials
- D02G3/045—Blended or other yarns or threads containing components made from different materials all components being made from artificial or synthetic material
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/22—Yarns or threads characterised by constructional features, e.g. blending, filament/fibre
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/448—Yarns or threads for use in medical applications
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
- D10B2331/04—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET]
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2401/00—Physical properties
- D10B2401/12—Physical properties biodegradable
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2401/00—Physical properties
- D10B2401/13—Physical properties anti-allergenic or anti-bacterial
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/04—Sutures
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to an antibacterial degradable medical suture, and belongs to the technical field of medical biomaterials. In order to solve the problem of current antibiotic durability poor and not absorbable nature, provide an antibiotic degradable medical suture, this suture includes degradable heart yearn and the braided wire layer of cladding outside the heart yearn, and the braided wire layer is mainly woven with degradable suture and is formed by absorbable suture, and degradable suture adopts the polylactic acid fiber line that degradable polylactic acid spinning formed, absorbable suture mainly is made by the raw materials of following parts by weight: collagen protein: 10-15; chitosan oligosaccharide: 15-20; amino acid polymer: 2.0 to 4.0; polysaccharide selenite: 0.8 to 1.0; silk fibroin: 2.0 to 3.0; the amino acid polymer is loaded with a medical antibacterial agent. Has high degradability and absorbability, long antibacterial effect, and high antibacterial activity, and can promote wound healing.
Description
Technical Field
The invention relates to an antibacterial degradable medical suture, and belongs to the technical field of medical biomaterials.
Background
Surgical sutures are the most common medical material used in surgical procedures to suture wounds. In recent years, although clips, nails, etc. have been used, sutures are still the main choice for suturing wounds in most operations.
The suture can be divided into absorbable suture and non-absorbable suture according to the biodegradation performance, the absorbable suture can slowly dissolve with the tissue after being sutured, the normal healing of the wound is not influenced in the process, and the absorbable suture can be degraded into soluble products in body tissues. The existing suture thread is made of natural catgut and collagen, while the suture thread made of synthetic materials is made of polyvinyl alcohol fiber, polylactic acid fiber and the like. The non-absorbable suture line is not degraded in vivo and has long supporting time, but is easy to cause tissue infection and the like because the non-absorbable suture line acts on body foreign matters left in tissues for a long time.
With the development and progress of medicine, people pay more and more attention to the safety of medical services, various bacteria often exist in the surrounding environment of surgical incision suturing, and common surgical sutures have no bacteriostatic action on the bacteria, so that the effective healing of wounds is directly influenced, and further the health is influenced. Therefore, how to research and develop a suture with good antibacterial performance has certain market and medical value. For example, in the prior art, it is reported that an antibacterial biodegradable medical suture is adopted, such as a suture prepared from raw materials of chitosan, prolamine, polycaprolactone, citric acid and honeysuckle extract. But still can not well realize the defects of degradability, absorbability and good antibacterial performance, and the suture lines are directly sewed by adopting a single line without using the antibacterial durability and the wound tissue healing.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides an antibacterial degradable medical suture, which solves the problems that: how to realize the combination of high antibacterial performance and degradable absorbable performance.
The invention aims to realize the following technical scheme that the antibacterial degradable medical suture comprises a degradable core wire and a braided wire layer coated outside the core wire, wherein the braided wire layer is mainly formed by weaving an absorbable suture and a degradable suture, the degradable suture adopts a polylactic acid fiber wire formed by spinning degradable polylactic acid, and the absorbable suture is mainly prepared from the following raw materials in parts by weight:
collagen protein: 10-15; chitosan oligosaccharide: 15-20; amino acid polymer: 2.0 to 4.0; polysaccharide selenite: 0.8 to 1.0; silk fibroin: 2.0 to 3.0; the amino acid polymer is loaded with a medical antibacterial agent.
The absorbable suture line is made of collagen, silk fibroin and chitosan oligosaccharide serving as main raw materials, so that the absorbable suture line can be well decomposed and absorbed by human tissues, and the suture line can have certain strength performance due to a small amount of mixed silk fibroin, so that the problem that the suture line is easy to break in the spinning process is solved; meanwhile, the weaving layer coated on the outer layer is formed by mixing and weaving the absorbable suture line and the degradable polylactic acid fiber line, the absorbable suture line can be slowly degraded and absorbed in the healing process of wound tissues in a mixing and weaving mode, micropores are formed on the surface of the braided layer, tissue cells can grow and migrate, the healing of the tissues is promoted, the degradable polylactic acid fiber line which is mixed and woven can ensure the strength of the suture line, and meanwhile, the core line is also formed by adopting a degradable material, so that the overall strength of the suture line can be maintained even after the absorbable suture line is degraded and absorbed; more importantly, chitosan oligosaccharide is added into the absorbable suture line, so that the absorbable suture line has better antibacterial performance, and the amino acid polymer is adopted to load the medical antibacterial agent, so that the absorbable suture line has certain slow release capability, and in the healing process of tissues, the antibacterial agent can be slowly released due to the adsorption of the amino acid polymer, so that the absorbable suture line has antibacterial long-acting performance; the added polysaccharide selenite can promote antibacterial activity, improve the overall antibacterial performance, enable the antibacterial activity to be high for staphylococcus aureus and escherichia coli, improve the immunoregulation capability after the polysaccharide selenite is added, be more beneficial to promoting the tissue healing capability, and integrally realize the effects of high antibacterial and anti-inflammatory activity and degradability.
In the above antibacterial degradable medical suture, it is preferable that the amino acid polymer is γ -polyglutamic acid or β -polyglutamic acid. The polyglutamic acid antibacterial agent has degradable performance, and the polyglutamic acid skeleton structure can better promote the antibacterial agent to be attached to the surface of the polyglutamic acid skeleton structure, so that the polyglutamic acid antibacterial agent can be better released, has better antibacterial long-acting property, and can more effectively avoid inflammation of wounds. Preferably, the gamma-polyglutamic acid (gamma-PGA) has good biocompatibility and biodegradability, can better ensure the antibacterial property of the medicament when being used as a load material of the antibacterial agent, and also has good slow release performance.
In the above antibacterial degradable medical suture, it is preferable that the polysaccharide selenite is one or more selected from the group consisting of algal selenium polysaccharide, dextran selenite and arabinoxylan selenite. Can better promote the antibacterial activity capability and the antibacterial long-acting performance. As another preferred embodiment, the polysaccharide of the polysaccharide selenite is selected from chitosan. The chitosan polysaccharide can better form compatibility with the main raw material, and can also promote the antibacterial activity of the material.
In the antibacterial degradable medical suture, the medical antibacterial agent is preferably selected from curcumin and/or antibacterial quaternary ammonium salt. The material has better adsorption capacity with the loaded amino acid polymer, and can form bonding with the functional group of the amino acid polymer, thereby improving the stability and better ensuring the antibacterial capacity of the material. Antibacterial quaternary ammonium salts are preferred. Further, the medical antibacterial agent is a mixture of curcumin and antibacterial quaternary ammonium salt, and the mass ratio of the curcumin to the antibacterial quaternary ammonium salt is 0.3: 0.8 to 1.0. Further, it is preferable that the antibacterial agent accounts for 2.0 to 3.0% by mass of the amino acid polymer.
In the above antibacterial degradable medical suture, it is preferable that the core wire is made of a degradable polylactic acid fiber wire, and the surface of the core wire is coated with an antibacterial and anti-inflammatory coating coated with collagen. On the one hand, because the surface of the core wire is coated with the braided layer, in the process of healing the tissue after suturing, the outer absorbable suture is slowly degraded and absorbed, so that the outer layer forms partial pores, tissue cells grow in, thus the surface antibacterial coating of the core wire is contacted with the tissue at the wound, and the coated collagen also has absorbability, thus the antibacterial material in the outer layer can be released slowly, and further the antibacterial ability is achieved, thus the long-acting antibacterial ability is better realized.
In the antibacterial degradable medical suture, the antibacterial anti-inflammatory agent coating is specifically processed by pre-soaking the antibacterial anti-inflammatory agent in collagen slurry, and then the coating forms an antibacterial anti-inflammatory coating on the surface of the core wire, wherein the thickness of the antibacterial anti-inflammatory coating is 0.3-0.5 mm. Preferably, the antibacterial and anti-inflammatory agent is ciprofloxacin.
In summary, compared with the prior art, the invention has the following advantages:
1. the weaving layer coated on the outer layer is formed by mixing and weaving the absorbable suture line and the degradable polylactic acid fiber line, so that the absorbable suture line can be slowly degraded and absorbed in the healing process of wound tissues, micropores are formed on the surface, tissue cells can grow and migrate, the healing of the tissues is promoted, and the strength of the suture line can be ensured by the degradable polylactic acid fiber line which is mixed and woven; meanwhile, the material tissue is beneficial to promoting the healing capacity of the tissue, and the high antibacterial and anti-inflammatory activity and the degradable effect are integrally realized.
2. The surface of the core wire is coated with an antibacterial and anti-inflammatory coating which is coated with collagen. The antibacterial function can be further achieved, so that the long-acting antibacterial function can be better achieved, after the absorbable suture in the outer layer weaving is slowly degraded and absorbed in the tissue healing process, the antibacterial function is reduced or the absorbable suture is ineffective, the antibacterial material of the inner layer still can play a role after the absorbable suture is absorbed, the antibacterial function is slowly released, and the long-acting antibacterial function is achieved.
Drawings
Fig. 1 is a cross-sectional structural view of the antibacterial degradable medical suture line of the present invention.
In the figure, 1, core wire, 2, braided wire layer.
Detailed Description
The technical solutions of the present invention will be further specifically described below with reference to specific examples and drawings, but the present invention is not limited to these examples.
Combine shown in fig. 1, this antibiotic degradable medical suture includes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn, braided wire layer 2 mainly is woven by absorbable suture and degradable suture and forms, can adopt absorbable suture and degradable suture to carry out forward winding respectively and weave with reverse winding's cross winding mode here and form, also can make to adopt absorbable suture and degradable suture blending, adopt absorbable suture and degradable suture to ply into a yarn as the yarn on braided wire layer through doubling machine, the braided wire that the twisting of many yarns formed carries out the best messenger, furthermore, the root quantity that can absorb suture and degradable suture in the braided wire that makes every twisting is 1 best: 1-1: 3. the diameters of the absorbable suture lines and the degradable suture lines are both 0.2-0.8 mm, in the following embodiments, the diameters of the absorbable suture lines and the degradable suture lines are preferably both 0.5mm, and the number of the absorbable suture lines and the degradable suture lines in each twisted braided wire is 1: 1, the strength performance of the suture can be better ensured. After the suture is used for wound suturing, the absorbable suture is degraded and absorbed in the wound healing process, tiny pores can be formed, and healing growth of tissues is promoted better. Furthermore, the degradable suture is preferably formed by spinning degradable fibers, and more importantly, the absorbable suture is preferably mainly prepared from the following raw materials in parts by weight:
collagen protein: 10-15; chitosan oligosaccharide: 15-20; amino acid polymer: 2.0 to 4.0; polysaccharide selenite: 0.8 to 1.0; silk fibroin: 2.0 to 3.0; the amino acid polymer is loaded with a medical antibacterial agent. The antibacterial fabric has good absorbability and high antibacterial ability, and can be absorbed, degraded and have high antibacterial activity, and the antibacterial activity reaches more than 85%. The corresponding suture line can be made by the conventional general spinning method in the field.
In a further scheme, the amino acid polymer in the raw materials of the absorbable suture is gamma-polyglutamic acid or beta-polyglutamic acid, and the gamma-polyglutamic acid is preferably adopted, so that the loading capacity of the antibacterial agent can be better realized, and the stability and the slow release performance of the antibacterial agent can be improved. The weight average molecular weight of the chitosan oligosaccharide can be 2500-3000 Da.
The polysaccharide selenite is preferably one or more of algal selenium polysaccharide, dextran selenite and arabinoxylan selenite. Can better ensure that the antibacterial agent has high antibacterial activity and long-acting performance.
As another embodiment, the polysaccharide of the polysaccharide selenite is selected from chitosan. Specifically, a selenium compound solution with the mass fraction of 75% -78% is sprayed and added into chitosan under the stirring condition, the reaction is carried out at the temperature of 130-145 ℃ for 12-14 hours, the reaction is carried out under the protection of nitrogen, and the corresponding polysaccharide selenite is obtained, wherein the polysaccharide is chitosan, and the selenium compound is selenious acid or sodium selenite. Preferably, the mass ratio of the chitosan to the selenium compound is 5-6: 1. the collagen can be derived from animal.
In a more preferred embodiment, the medical antibacterial agent is selected from curcumin and/or antibacterial quaternary ammonium salt. The antibacterial quaternary ammonium salt is preferably chitosan quaternary ammonium salt: the chitosan quaternary ammonium salt with the substitution degree can be prepared by the chitosan and the epoxypropyl trimethyl ammonium chloride, and the corresponding chitosan quaternary ammonium salt can be obtained. Can well form good stability and slow release performance with the loaded gamma-polyglutamic acid or beta-polyglutamic acid. The antimicrobial agent is preferably contained in an amount of 2.0 to 3.0%, more preferably 2.5% by mass based on the amino acid polymer. In a better embodiment, the medical antibacterial agent is a mixture of curcumin and antibacterial quaternary ammonium salt, and the mass ratio of the curcumin to the antibacterial quaternary ammonium salt is 0.3: 0.8-1.0, optimally 0.3: 0.83.
as a better embodiment, the core wire is made of degradable polylactic acid fiber wire, the surface of the core wire 1 is coated with an antibacterial and antiphlogistic coating coated with collagen, wherein the collagen is preferably the same as the collagen in the absorbable suture. Further, the antibacterial and anti-inflammatory agent coating is specifically prepared by pre-soaking the antibacterial and anti-inflammatory agent in collagen liquid for treatment, and then coating the collagen liquid on the surface of the core wire to form the antibacterial and anti-inflammatory coating, wherein the thickness of the antibacterial and anti-inflammatory coating is 0.3-0.5 mm. Preferably, the antibacterial and anti-inflammatory agent is ciprofloxacin. The mass content of the antibacterial and anti-inflammatory agent in the antibacterial and anti-inflammatory coating is 0.5-0.8%.
Example 1
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 10; chitosan oligosaccharide: 20; gamma-polyglutamic acid: 4.0; seaweed selenium polysaccharide: 1.0; silk fibroin: 3.0; the gamma-polyglutamic acid is loaded with a medical antibacterial agent chitosan quaternary ammonium salt, and the mass percentage of the chitosan quaternary ammonium salt in the gamma-polyglutamic acid is 2%.
The specific suture line processing method and the specific spinning processing method are all processed by adopting the conventional processing mode in the field.
Example 2
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 15; chitosan oligosaccharide: 18; beta-polyglutamic acid: 2.0; dextran selenite: 0.8; silk fibroin: 2.0; the beta-polyglutamic acid is loaded with a medical antibacterial agent curcumin, and the curcumin accounts for 2.5 percent of the mass of the beta-polyglutamic acid.
Example 3
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 13; chitosan oligosaccharide: 15; gamma-polyglutamic acid: 3.0; arabinoxylan selenite: 0.9; silk fibroin: 2.5; the gamma-polyglutamic acid is loaded with the chitosan quaternary ammonium salt, and the mass percentage of the chitosan quaternary ammonium salt in the gamma-polyglutamic acid is 3.0%.
Example 4
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 12; chitosan oligosaccharide: 16, the weight average molecular weight of the chitosan oligosaccharide is 2500 Da; gamma-polyglutamic acid: 2.6; polysaccharide selenite: 0.85; silk fibroin: 2.4; the gamma-polyglutamic acid is loaded with chitosan quaternary ammonium salt, the mass percentage of the chitosan quaternary ammonium salt in the gamma-polyglutamic acid is 2.8%, and the polysaccharide of the polysaccharide selenite is chitosan.
Example 5
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 11; chitosan oligosaccharide: 16, the weight average molecular weight of the chitosan oligosaccharide is 3000 Da; gamma-polyglutamic acid: 3.2; polysaccharide selenite: 0.86 of the total weight of the mixture; silk fibroin: 2.8; the gamma-polyglutamic acid is loaded with a medical antibacterial agent, the antibacterial agent accounts for 2.5% of the mass of the gamma-polyglutamic acid, the antibacterial agent is a mixture of chitosan quaternary ammonium salt and curcumin, and the mass ratio of the curcumin to the chitosan quaternary ammonium salt is 0.3: 0.8, wherein the polysaccharide of polysaccharide selenite is chitosan.
Example 6
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 14; chitosan oligosaccharide: 17; gamma-polyglutamic acid: 3.1; polysaccharide selenite: 0.9; silk fibroin: 2.5; the gamma-polyglutamic acid is loaded with a medical antibacterial agent, the antibacterial agent accounts for 3% of the mass of the gamma-polyglutamic acid, the antibacterial agent is a mixture of chitosan quaternary ammonium salt and curcumin, and the mass ratio of the curcumin to the chitosan quaternary ammonium salt is 0.3: 1.0, wherein the polysaccharide of polysaccharide selenite is chitosan.
Example 7
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 10; chitosan oligosaccharide: 20; gamma-polyglutamic acid: 4.0; seaweed selenium polysaccharide: 1.0; silk fibroin: 3.0; the gamma-polyglutamic acid is loaded with a medical antibacterial agent chitosan quaternary ammonium salt, and the mass percentage of the chitosan quaternary ammonium salt in the gamma-polyglutamic acid is 2%.
The surface of the core wire 1 is coated with an antibacterial and anti-inflammatory coating which is coated by collagen, the thickness of the antibacterial and anti-inflammatory coating is 0.3mm, the collagen can be the same as the collagen capable of absorbing suture lines, and the antibacterial and anti-inflammatory agent in the antibacterial and anti-inflammatory coating is ciprofloxacin, which accounts for 0.5 percent of the mass of the antibacterial and anti-inflammatory coating.
Example 8
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 13; chitosan oligosaccharide: 15; gamma-polyglutamic acid: 3.0; arabinoxylan selenite: 0.9; silk fibroin: 2.5; the gamma-polyglutamic acid is loaded with the chitosan quaternary ammonium salt, and the mass percentage of the chitosan quaternary ammonium salt in the gamma-polyglutamic acid is 3.0%.
The surface of the core wire 1 is coated with an antibacterial and anti-inflammatory coating which is coated by collagen, the thickness of the antibacterial and anti-inflammatory coating is 0.5mm, the collagen can be the same as the collagen capable of absorbing suture lines, and the antibacterial and anti-inflammatory agent in the antibacterial and anti-inflammatory coating is ciprofloxacin, which accounts for 0.8 percent of the mass of the antibacterial and anti-inflammatory coating.
Example 9
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 14; chitosan oligosaccharide: 17; gamma-polyglutamic acid: 3.1; polysaccharide selenite: 0.9; silk fibroin: 2.5; the gamma-polyglutamic acid is loaded with a medical antibacterial agent, the antibacterial agent accounts for 3% of the mass of the gamma-polyglutamic acid, the antibacterial agent is a mixture of chitosan quaternary ammonium salt and curcumin, and the mass ratio of the curcumin to the chitosan quaternary ammonium salt is 0.3: 1.0, wherein the polysaccharide of polysaccharide selenite is chitosan.
The surface of the core wire 1 is coated with an antibacterial and anti-inflammatory coating which is coated by collagen, the thickness of the antibacterial and anti-inflammatory coating is 0.4mm, the collagen can absorb the same collagen of a suture, the antibacterial and anti-inflammatory agent in the antibacterial and anti-inflammatory coating is ciprofloxacin, and the ciprofloxacin accounts for 0.6 percent of the mass of the antibacterial and anti-inflammatory coating.
Example 10
The antibiotic degradable medical suture of this embodiment includes that it makes heart yearn 1 and the braided wire layer 2 of cladding outside the heart yearn to be made by degradable polylactic acid fibre line, and the braided wire layer is mainly woven by absorbable suture and degradable suture and is formed, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 11; chitosan oligosaccharide: 16, the weight average molecular weight of the chitosan oligosaccharide is 3000 Da; gamma-polyglutamic acid: 3.2; polysaccharide selenite: 0.86 of the total weight of the mixture; silk fibroin: 2.8 of; the gamma-polyglutamic acid is loaded with a medical antibacterial agent, the antibacterial agent accounts for 2.5% of the mass of the gamma-polyglutamic acid, the antibacterial agent is a mixture of chitosan quaternary ammonium salt and curcumin, and the mass ratio of the curcumin to the chitosan quaternary ammonium salt is 0.3: 0.8, wherein the polysaccharide of polysaccharide selenite is chitosan.
The surface of the core wire 1 is coated with an antibacterial and anti-inflammatory coating which is coated by collagen, the thickness of the antibacterial and anti-inflammatory coating is 0.3mm, the collagen is the same as the collagen which can be absorbed by a suture line, the antibacterial and anti-inflammatory agent in the antibacterial and anti-inflammatory coating is ciprofloxacin, and the ciprofloxacin accounts for 0.7 percent of the mass of the antibacterial and anti-inflammatory coating.
Comparative example 1
In order to show the influence of the synergistic effect of the polysaccharide selenite and the amino acid polymer on the overall antibacterial capacity, the comparative example is implemented by comparing the polysaccharide selenite without adding, and the corresponding amino acid polymer is used to replace the original polysaccharide selenite.
The antibacterial degradable medical suture of this comparative example includes that core line 1 and the braided wire layer 2 of cladding outside the core line are made by degradable polylactic acid fibre line, and the braided wire layer mainly is woven by absorbable suture and degradable suture and forms, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture mainly is made by the raw materials of following parts by weight:
collagen protein: 10; chitosan oligosaccharide: 20; gamma-polyglutamic acid: 5.0; silk fibroin: 3.0; the gamma-polyglutamic acid is loaded with a medical antibacterial agent chitosan quaternary ammonium salt, and the mass percentage of the chitosan quaternary ammonium salt in the gamma-polyglutamic acid is 2%.
Comparative example 2
In order to show the influence of the synergistic effect of the polysaccharide selenite and the amino acid polymer on the overall antibacterial capacity, the comparative example is implemented by comparing without adding the amino acid polymer, and the corresponding polysaccharide selenite is used instead of the original amino acid polymer.
The antibacterial degradable medical suture of this comparative example includes that core line 1 and the braided wire layer 2 of cladding outside the core line are made by degradable polylactic acid fibre line, and the braided wire layer mainly is woven by absorbable suture and degradable suture and forms, and degradable suture adopts degradable polylactic acid fibre spinning to form, and absorbable suture mainly is made by the raw materials of following parts by weight:
collagen protein: 10; chitosan oligosaccharide: 20; seaweed selenium polysaccharide: 5.0; silk fibroin: 3.0.
the corresponding suture obtained in the above embodiment is randomly selected to perform a specific performance test, the specific antibacterial performance test is performed by using gram-negative escherichia coli and gram-positive staphylococcus aureus (test according to QB/T-2591-:
table 1:
in the table "-" means that there is substantially no bacteriostatic activity.
The above 10 days in table 1 indicate that the corresponding test was performed after 10 days after the suture of the corresponding example was used to suture the wound; 4 months, which means that after 4 months, the corresponding test was performed after the wound was sutured using the suture according to the corresponding example. From the above table, it can be seen that the present invention has the advantages of long-lasting bacteriostatic activity, and better prevention of bacterial infection and inflammation. Specifically, from the bacteriostatic ability of examples 1 to 6, it can be seen that, in the previous period, the absorbable suture thread is not completely absorbed, so that the absorbable suture thread has a better antibacterial ability, and after 4 months, the antibacterial ability is obviously reduced because the absorbable suture thread is mostly absorbed, and from the above data, it can be shown that the absorbable suture thread with antibacterial activity of the present invention is basically mostly absorbed after 4 months, so that the antibacterial ability is obviously reduced; in examples 7 to 10, however, the core wire 1 is coated with the antibacterial and anti-inflammatory coating layer according to the present invention. Therefore, the antibacterial agent still has good antibacterial ability in later stage, realizes long-acting high antibacterial activity effect, and also shows the advantages of good absorbability and high degradation. Meanwhile, as can be seen from the data effects of comparative examples 1 and 2, the synergistic effect of the polysaccharide selenite and the amino acid polymer has a good effect on the overall antibacterial ability, so that the overall antibacterial effect can be better improved.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.
While the invention has been described in detail and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope thereof.
Claims (8)
1. The utility model provides an antibiotic degradable medical stylolite, its characterized in that, this stylolite includes heart yearn and the braided wire layer of cladding outside the heart yearn, braided wire layer mainly weaves with degradable stylolite by absorbable suture and forms, degradable stylolite adopts degradable fiber spinning to form, absorbable suture is mainly made by the raw materials of following parts by weight:
collagen protein: 10-15; chitosan oligosaccharide: 15-20; amino acid polymer: 2.0 to 4.0; polysaccharide selenite: 0.8 to 1.0; silk fibroin: 2.0 to 3.0; the amino acid polymer is loaded with a medical antibacterial agent; the polysaccharide selenite is selected from one or more of alga selenium polysaccharide, dextran selenite and arabinoxylan selenite; the core wire is made of degradable polylactic acid fiber wires, and the surface of the core wire is coated with an antibacterial and anti-inflammatory coating coated with collagen.
2. The antibacterial and degradable medical suture of claim 1, wherein the amino acid polymer is gamma-polyglutamic acid or beta-polyglutamic acid.
3. The antibacterial degradable medical suture according to claim 1, wherein the polysaccharide of polysaccharide selenite is selected from chitosan.
4. The antibacterial degradable medical suture according to any one of claims 1 to 3, wherein the medical antibacterial agent is selected from curcumin and/or antibacterial quaternary ammonium salt.
5. The antibacterial degradable medical suture line according to claim 4, wherein the antibacterial agent accounts for 2.0-3.0% of the mass of the amino acid polymer.
6. The antibacterial degradable medical suture line according to any one of claims 1 to 3, wherein the medical antibacterial agent is a mixture of curcumin and an antibacterial quaternary ammonium salt, and the mass ratio of the curcumin to the antibacterial quaternary ammonium salt is 0.3: 0.8 to 1.0.
7. The antibacterial and degradable medical suture line according to any one of claims 1 to 3, wherein the antibacterial and anti-inflammatory agent coating is prepared by pre-soaking the antibacterial and anti-inflammatory agent in collagen slurry, and then coating the collagen slurry to form the antibacterial and anti-inflammatory coating on the surface of the core line, and the thickness of the antibacterial and anti-inflammatory coating is 0.3mm to 0.5 mm.
8. The antibacterial and degradable medical suture according to claim 7, wherein the antibacterial and anti-inflammatory agent is ciprofloxacin.
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| EP1879606B1 (en) * | 2005-04-25 | 2013-06-12 | Massachusetts Institute of Technology | Self-assembling peptides for promoting hemostasis |
| CN101104644B (en) * | 2006-07-14 | 2010-07-21 | 陈艺新 | Preparation for polysaccharide selenite and application thereof |
| CN101406710B (en) * | 2008-11-25 | 2013-02-13 | 同济大学 | Suture thread containing bioactive components and preparation method thereof |
| CN108042844A (en) * | 2017-12-11 | 2018-05-18 | 青岛大学 | A kind of preparation method of suture |
| CN111068100B (en) * | 2019-11-28 | 2022-07-05 | 深圳市迈捷生命科学有限公司 | Medical silk braided suture line and preparation method thereof |
| CN110947025A (en) * | 2019-12-18 | 2020-04-03 | 山东朱氏药业集团有限公司 | Absorbable medical suture line with good degradation resistance and compatibility and preparation method thereof |
| CN112516372A (en) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | Composite drug-loaded fiber for absorbable surgical suture |
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