CN113030480A

CN113030480A - Reagent preheating device and sample analyzer

Info

Publication number: CN113030480A
Application number: CN201911359193.9A
Authority: CN
Inventors: 张勇; 邓文华; 滕锦
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-12-25
Filing date: 2019-12-25
Publication date: 2021-06-25
Anticipated expiration: 2039-12-25
Also published as: CN113030480B

Abstract

The embodiment of the application discloses a reagent preheating device and a sample analyzer, which comprise a first pipeline assembly and a second pipeline assembly, wherein the first pipeline assembly comprises a first preheating base body and a first pipeline for conveying a first reagent, and the first preheating base body is used for preheating the first reagent; the second pipeline assembly comprises a second preheating base body and a second pipeline for conveying a second reagent, one end of the second pipeline is connected with the first pipeline, the second preheating base body is used for preheating the second reagent, and the second pipeline conveys the second reagent to the reaction tank through the first pipeline under the action of a pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to a reaction tank together with the first reagent in the first pipeline; the diameter of the second pipeline is larger than that of the first pipeline, so that the preheating speed of the first reagent is larger than that of the second reagent.

Description

Reagent preheating device and sample analyzer

Technical Field

The application relates to the technical field of medical equipment, in particular to a reagent preheating device and a sample analyzer.

Background

When a sample is tested, the antigen-antibody reaction binding speed in the CRP reaction process is greatly influenced by temperature, the temperature is higher, the reaction rate is increased, and the obtained CRP value is higher than a true value; if the temperature is lower, the reaction rate is reduced, and the obtained CRP value is lower than the true value, so that the CRP value obtained by the detection system has larger difference, and the consistency and the accuracy of the measurement result are influenced.

The CRP measuring system used at present can not preheat two or three reagents together, and needs to separately preheat and mix a plurality of reagents, so that the structural design is complex, and the manufacturing and maintenance costs are high.

Disclosure of Invention

The application provides a reagent preheating device and sample analyzer can preheat two kinds of reagents simultaneously through first pipeline and first pipeline, and not only simple structure, the cost of manufacture is low moreover.

According to a first aspect of the present application, there is provided a reagent preheating device comprising:

the first pipeline assembly comprises a first preheating base body and a first pipeline for conveying a first reagent, and the first preheating base body is used for preheating the first reagent;

the second pipeline assembly comprises a second preheating base body and a second pipeline for conveying a second reagent, one end of the second pipeline is connected with the first pipeline, the second preheating base body is used for preheating the second reagent, and the second pipeline conveys the second reagent to the reaction tank through the first pipeline under the action of a pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to a reaction tank together with the first reagent in the first pipeline;

wherein the diameter of the second pipeline is larger than that of the first pipeline, so that the preheating speed of the first reagent is larger than that of the second reagent.

In the preheating device of this application, first pipeline is the heliciform and winds around establishing on the first preheating basal body, and/or the second pipeline is the heliciform and winds around establishing on the second preheating basal body.

In the preheating device of this application, be equipped with first base member helicla flute on the first preheating base member, the diameter of first base member helicla flute with the diameter looks adaptation of first pipeline, first pipeline winding is in on the first base member helicla flute.

In the preheating device of the application, the second is preheated and is equipped with the second base member helicla flute on the base member, the diameter of second base member helicla flute with the diameter looks adaptation of second pipeline, the winding of second pipeline is in on the second base member helicla flute.

In the preheating device of this application, first pipeline with the outside of second pipeline all is wrapped up has the heat preservation cotton, is used for right first reagent in the first pipeline reaches second reagent in the second pipeline keeps warm.

In the preheating device of the present application, the first preheating base body is installed at the upper end of the second preheating base body, and the diameter of the first preheating base body is equal to the diameter of the second preheating base body.

In the preheating device of this application, preheating device includes the heat accumulation base member and heating source, be provided with the base member installation department on the heat accumulation base member, the second preheats the lower extreme of base member and installs on the base member installation department, the heating source be used for to the heat accumulation base member heating.

In the preheating device of this application, preheating device includes the retaining member, the base member installation department is equipped with fixing hole, first preheating is equipped with first base member through-hole on the base member, the second preheating is equipped with second base member through-hole on the base member, the retaining member passes in proper order connect behind first base member through-hole and the second base member through-hole on the fixing hole.

In the preheating device of this application, preheating device still includes the adapter tube, first pipeline pass through the adapter tube with the second pipeline intercommunication.

In the preheating device of the application, the preheating device further comprises a quick coupling, and the first pipeline is communicated with the second pipeline through the quick coupling.

In the preheating device, the first reagent is an emulsion reagent, the second reagent is a hemolytic agent, and the first pipeline conveys the emulsion reagent to the first pipeline for preheating under the action of the pressure source; the second pipeline conveys the hemolytic agent to the second pipeline for preheating and then to the first pipeline under the action of the pressure source, and the hemolytic agent and the latex reagent are mixed in the first pipeline and then conveyed to the reaction tank.

According to a second aspect of the present application, there is also provided a sample analyzer comprising:

the reaction tank is arranged on the sample analyzer and is provided with a liquid inlet;

the liquid storage device comprises a first reagent liquid supply device for storing the first reagent and a second reagent liquid supply device for storing the second reagent;

the sampling device is used for collecting samples and comprises a sampling needle and a sampling needle driving part for driving the sampling needle to move, the sampling needle driving part drives the sampling needle to collect the samples and distributes the collected samples to the reaction pool; and

the preheating device comprises a first pipeline and a second pipeline, one end of the first pipeline, which is far away from the second pipeline, is divided into two paths, one path is connected to the first reagent liquid supply device, the other path is connected to the reaction tank, one end of the second pipeline is connected with the first pipeline, and the other end of the second pipeline is connected with the second reagent liquid supply device, so that a first reagent on the first reagent liquid supply device can be conveyed to the first pipeline for preheating, and a second reagent on the second reagent liquid supply device can be conveyed to the second pipeline for preheating under the action of a pressure source of the first pipeline and the second pipeline;

after preheating of the first reagent on the first pipeline and the second reagent on the second pipeline is completed, the second pipeline conveys the second reagent to the reaction tank through the first pipeline under the action of the pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to a reaction tank together with the first reagent in the first pipeline. In the sample analyzer of this application, sample analyzer is still including setting up the reaction tank with cylinder manifold between the preheating device, the cylinder manifold is equipped with liquid outflow end and liquid entering end, the liquid outflow end with the inlet intercommunication, first pipeline warp the cylinder manifold is carried to the reaction tank.

In the sample analyzer, the sample analyzer further comprises a first control valve and a second control valve, the first control valve is respectively connected with the first pipeline, the first reagent liquid supply device and the reaction tank, and the second control valve is respectively connected with the second pipeline, the pressure source and the second reagent liquid supply device;

a first reagent in the first reagent liquid supply device enters a first pipeline under the control of the pressure source, the first control valve and the second control valve, and is preheated in the first pipeline;

a second reagent in the second reagent liquid supply device enters a second pipeline under the control of the pressure source and a second control valve and is preheated in the second pipeline;

after preheating of a first reagent on the first pipeline and a second reagent on the second pipeline is completed, conveying the second reagent in the second pipeline to the confluence plate through the first pipeline under the control of the pressure source, the first control valve and the second control valve; and/or the second reagent is conveyed into the first pipeline and conveyed to the confluence plate together with the first reagent in the first pipeline.

In the sample analyzer of this application, sample analyzer still includes the reaction cell mount pad, the reaction cell mount pad orientation one side of preheating device is equipped with the fixing base, the cylinder manifold is installed on the fixing base, first control valve and second control valve are all installed on the cylinder manifold.

In the sample analyzer of this application, the fixing base is installed the upper end of reaction tank mount pad, the cylinder manifold is installed the lower extreme of fixing base, first control valve and second control valve are located the below of cylinder manifold.

In the sample analyzer of this application, the bottom of reaction tank mount pad is equipped with the bedplate, the last heat accumulation base member of preheating device is L type structure, the horizontal end of heat accumulation base member is placed on the bedplate, the vertical end of heat accumulation base member is fixed on the lateral wall of reaction tank mount pad.

In the sample analyzer of this application, be equipped with the pipeline through-hole on the heat accumulation base member, be equipped with the bedplate through-hole on the bedplate, the position of pipeline through-hole with the position of bedplate through-hole is corresponding, so that first pipeline and second pipeline can pass behind pipeline through-hole and the bedplate through-hole with the stock solution device intercommunication.

In the sample analyzer of this application, the reaction cell mount pad is equipped with the mounting groove, the mounting groove has first opening and second opening, first opening sets up respectively with the second opening on two adjacent terminal surfaces of reaction cell mount pad, the reaction cell passes through first opening is installed on the mounting groove, the sample addition mouth orientation of reaction cell the second open-ended direction, the inlet orientation first open-ended outside.

In the sample analyzer of this application, be connected with the inlet liquor pipeline that is L type structure on the inlet, inlet liquor pipeline's one end certainly first opening to the mounting groove extends, inlet liquor pipeline's the other end with the cylinder manifold links to each other.

In the sample analyzer of the present application, the reaction cell mount pad is further provided with:

the light-emitting device is arranged on one side of the mounting groove and can emit light towards the reaction cavity;

and the receiving device is arranged on the other side of the mounting groove opposite to the light-emitting device and can receive the light scattered from the reaction tank.

In the sample analyzer of the present application, the income plain noodles of mounting groove with light emitting device to the light that the reaction tank sent is the slope contained angle setting.

The technical scheme provided by the embodiment of the application can have the following beneficial effects: the application designs a reagent preheating device and sample analysis, which comprises a first pipeline assembly and a second pipeline assembly, wherein the first pipeline assembly is provided with a first preheating matrix and a first pipeline for conveying a first reagent, and the second pipeline assembly is provided with a second preheating matrix and a second pipeline for conveying a second reagent, so that the first reagent on the first pipeline can be preheated through the first preheating matrix, and the second reagent on the second pipeline can be preheated through the second preheating matrix; when the first reagent and the second reagent are preheated, the second pipeline conveys the second reagent to the reaction tank through the first pipeline under the action of the pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to the reaction tank together with the first reagent in the first pipeline, so that the structure is simple, and the manufacturing cost is low.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a reagent preheating device according to an embodiment of the present invention;

FIG. 2 is a schematic fluid circuit diagram of the reagent preheating device of FIG. 1;

FIG. 3 is an exploded schematic view of the reagent preheating device of FIG. 1;

FIG. 4 is a partially exploded schematic view of the reagent preheating device of FIG. 1;

FIG. 5 is a partially exploded schematic view of the reagent preheating device of FIG. 1;

FIG. 6 is a schematic structural view of the second pipeline assembly of FIG. 1;

FIG. 7 is a schematic cross-sectional view of the second conduit assembly of FIG. 1;

FIG. 8 is an exploded schematic view of the second tube assembly of FIG. 1;

FIG. 9 is a schematic view of the second circuit of FIG. 1;

FIG. 10 is a schematic structural view of the first tube assembly of FIG. 1;

FIG. 11 is a schematic cross-sectional view of the first conduit assembly of FIG. 1;

FIG. 12 is an exploded schematic view of the first tube assembly of FIG. 1;

FIG. 13 is a schematic view of the first circuit of FIG. 1;

FIG. 14 is a schematic view of a portion of a sample analyzer according to yet another embodiment of the present application;

FIG. 15 is a partially exploded schematic view of the sample analyzer of FIG. 14;

FIG. 16 is a partially exploded schematic view of the sample analyzer of FIG. 14;

FIG. 17 is a partially exploded schematic view of the sample analyzer of FIG. 14;

fig. 18 is a schematic partial cross-sectional view of the sample analyzer of fig. 14.

Description of reference numerals:

100. a preheating device;

10. a first conduit assembly; 11. a first pre-heated substrate; 111. a first base through-hole; 112. a first matrix helical groove; 12. a first pipeline; 20. a second pipe assembly; 21. a second preheating substrate; 211. a second substrate through-hole; 212. a second base body screw hole; 213. a second matrix helical groove; 22. a second pipeline; 30. a cover body; 31. a hollow structure; 40. a heat storage matrix; 41. a fixing through hole; 42. a conduit through hole; 43. a heat storage base fixing portion; 50. a pressure source; 60. a first reagent supply device; 70. a second reagent supply device;

200. a reaction tank; 201. a liquid inlet; 202. a sample addition port; 203. a liquid inlet pipeline;

300. a reaction tank mounting seat; 301. a first opening; 302. a second opening; 303. a seat plate; 3031. a seat plate through hole; 304. a light exit channel; 305. a light inlet channel;

400. a bus bar; 401. a liquid inlet end; 402. a liquid outflow end;

500. a control valve; 501. a first control valve; 502. a second control valve;

600. a fixed seat;

700. a compression member;

800. a light emitting device;

900. a receiving device.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

The reagent preheating device of this application belongs to medical instrument field technical field, applies to the sample analysis appearance, and the sample analysis appearance includes one or several kinds among biochemical analyzer, immunoassay appearance, blood cell analysis appearance, special protein analysis appearance, glycated haemoglobin analysis appearance and the blood type analysis appearance for detect and the analysis specific organism composition, chemical substance etc. that contain in the sample.

In modern medical clinical examination laboratories, a sample analyzer detects specific biological components or chemical substances in a sample through a reaction cell, generally, a plurality of reagents are used in sample analysis, different reagents are mixed and reacted with the sample, and the sample is judged according to a reaction result; and the reaction between the reagent and the sample usually needs to be carried out within a preset temperature range, so that a temperature environment with the temperature within the preset temperature range is provided for the reaction between the sample and the reagent, so that the sample and the reagent can carry out efficient and sufficient reaction, qualified reaction liquid is provided for each detection, and the detection accuracy and repeatability are improved.

At present, a reagent preheating device is adopted to preheat a reagent, so that the temperature of the reagent is ensured to be within a preset range. However, the conventional reagent preheating device can only preheat one reagent, and cannot realize simultaneous preheating of two or more reagents.

As shown in fig. 1 to 14, according to a first aspect of the present application, there is provided a reagent preheating device 100 comprising a first pipe assembly 10 and a second pipe assembly 20, wherein the first pipe assembly 10 comprises a first preheating substrate 11 and a first pipe 12, the first pipe 12 is used for conveying a first reagent, and the first preheating substrate 11 is used for preheating the first reagent; the second pipe assembly 20 comprises a second preheating substrate 21 and a second pipe 22, the second pipe 22 is used for conveying a second reagent, and the second preheating substrate 21 is used for preheating the second reagent.

In this embodiment, the diameter D2 of the second conduit 22 is greater than the diameter D1 of the first conduit 12 to ensure that the pre-heating rate of the first reagent is greater than the pre-heating rate of the second reagent, wherein one end of the second conduit 22 is connected to the first conduit 12. When the second pipeline 22 is under the action of the pressure source 50, the second pipeline 22 delivers the second reagent to the reaction cell 200 through the first pipeline 12; and/or the second reagent is delivered to the first pipeline 12 and is delivered to the reaction cell 200 together with the first reagent in the first pipeline 120.

Specifically, one end of the second pipeline 22 is communicated with one end of the first pipeline 12 through a switching tube or a quick coupling, the other end of the first pipeline 12 is divided into two branches, namely a first branch and a second branch, the first branch is connected to the first reagent liquid supply device 60, and the second branch is connected to the reaction tank 200; the other end of the second pipeline 22 is divided into a third branch and a fourth branch, the third branch is connected to the second reagent supply device 70, and the fourth branch is connected to the pressure source 50.

After the above technical solution is adopted, when the first reagent flows from the first reagent supply device 60 through the first branch line and enters the first pipeline 12 under the control of the pressure source 50, so that the first preheating substrate 11 can preheat the first reagent in the first pipeline 12; when the second reagent is controlled by the pressure source 50, the second reagent flows from the second reagent supply device 70 through the third branch and enters the second pipeline, so that the second preheating substrate 21 can preheat the second reagent in the second pipeline 22. After preheating of the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22 is completed, the second reagent in the second pipeline 22 is transported to the reaction tank 200 through the first pipeline 12 under the control of the pressure source 50; and/or the second reagent is delivered into the first pipeline 12 and is delivered to the reaction cell 200 together with the first reagent in the first pipeline 12.

It should be noted that the preheating device 100 of the present application has only the first and

second pipeline assemblies

10 and 20, and may be configured according to the kind of reagent to be used in the detection, which is not limited in the present application.

In an alternative embodiment, as shown in fig. 4 to 13, the first pipe 12 is spirally wound around the first preheating substrate 11, and/or the second pipe 22 is spirally wound around the second preheating substrate 21, so as to ensure that the preheating temperatures of the radial sections on the first pipe 12 and the second pipe 22 can be kept consistent, and the first reagent and the second reagent are prevented from being heated unevenly, thereby reducing the accuracy of the detection result.

Specifically, first pipeline 12 is in the outside of first preheating base member 11 along the axial direction winding of first preheating base member 11, second pipeline 22 is in the outside of second preheating base member 21 along the axial direction winding of second preheating base member 21, not only can avoid first reagent to produce the difference in temperature in the first axial direction who preheats base member 11, and the second reagent produces the difference in temperature in the second axial direction who preheats base member 21, and first reagent and second reagent flow in the spiral pipeline can constantly change flow direction and flow state, reduce the radial difference in temperature of first reagent and second reagent in the pipeline, play the effect of intensive heat transfer. After the technical scheme is adopted, the first reagent and the second reagent can be ensured to carry out efficient and sufficient reaction within a preset temperature range, qualified reaction liquid is provided for each item of detection, and the accuracy and the repeatability of the detection are improved.

In addition, since the second reagent can be delivered into the first pipeline 12 and delivered to the reaction cell 200 together with the first reagent in the first pipeline 12, the second reagent flowing through the first pipeline 12 can be turbulent and continuously disturbed by utilizing the characteristic that the diameter D1 of the first pipeline 12 is smaller than the diameter D2 of the second pipeline 22 and the shape of the first pipeline 12, so as to achieve uniform mixing, thereby ensuring that the first reagent and the second reagent can fully react in the first pipeline 12.

In an alternative embodiment, the first preheating base 11 is provided with a first base spiral groove 112, and the diameter of the first base spiral groove 112 is adapted to the diameter of the first pipe 12, so that the first pipe 12 can be wound on the first preheating base 11 in the direction of the first base spiral groove 112.

Specifically, first base spiral groove 112 sets up along the axial direction of first preheating base 11, and the diameter D1 of first base spiral groove 112 is more than or equal to the diameter of first pipeline 12, not only can increase the area of contact of first pipeline 12 with first preheating base 11 like this, improve the preheating effect of first reagent in first pipeline 12, and also can make fixing that first pipeline 12 can be more firm on first preheating base 11, ensure that first pipeline 12 can tightly laminate on first preheating base 11.

In an alternative embodiment, the second preheating base 21 is provided with a second base spiral groove 213, and the diameter of the second base spiral groove 213 is adapted to the diameter of the second line 22, so that the second line can be wound on the second preheating base 21 in the direction of the second base spiral groove 213.

Specifically, the second substrate spiral groove 213 is arranged along the axial direction of the second preheating substrate 21, and the diameter of the second substrate spiral groove 213 is greater than or equal to the diameter D2 of the second pipeline 22, so that not only the contact area between the second pipeline 22 and the second preheating substrate 21 can be increased, the preheating effect of the second reagent in the second pipeline 22 is improved, but also the second pipeline 22 can be more stably fixed on the second preheating substrate 21, and the second pipeline 22 can be tightly attached to the second preheating substrate 21.

In an alternative embodiment, the first pipeline 12 and the second pipeline 22 are coated with insulation cotton for insulating the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22.

Specifically, the heat preservation cotton can twine respectively on first pipeline 12 and second pipeline 22's the outside, perhaps the heat preservation cotton also can twine the outside that first preheating base member 11 and second preheated base member 21, when first pipeline 12 and second pipeline 22 install respectively that first preheating base member 11 and second preheat base member 21, so that the heat preservation cotton can cover first pipeline 12 and second pipeline 22, thereby can keep warm to the first reagent in first pipeline 12 and the second reagent in the second pipeline 22.

In an alternative embodiment, the preheating device 100 further includes a cover 30, the cover 30 has a hollow structure 31, and the first pipeline assembly 10 and the second pipeline assembly 20 are installed in the hollow structure 31 to prevent the first pipeline 12 and the second pipeline 22 from being directly exposed to the outside, so as to better protect the first pipeline 12 and the second pipeline 22. In addition, the heat preservation cotton can also be arranged on the inner wall of the hollow structure 31, so that when the first pipeline assembly 10 and the second pipeline assembly 20 are arranged in the hollow structure 31, the heat preservation cotton can wrap the first pipeline 12 and the second pipeline 22, and heat preservation of the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22 can be realized.

In an alternative embodiment, the first preheating substrate 11 is installed at the upper end of the second preheating substrate 21, and the diameter of the first preheating substrate 11 is equal to that of the second preheating substrate 21, so that not only can heat be transferred to the first preheating substrate 11 through the second preheating substrate 21, so that the first preheating substrate 11 and the second preheating substrate 21 can preheat the first reagent in the first pipeline 12 and the first reagent in the second pipeline 22 simultaneously, but also the whole preheating device 100 is more compact in structure, the occupied area of the preheating device 100 is reduced, and the cost is saved.

It should be noted that the first preheating substrate 11 and the second preheating substrate 21 are made of the same heat conducting material, so that the first preheating substrate 11 and the second preheating substrate 21 can be ensured to have the same preheating temperature, and then the preheating speeds of the first reagent and the second reagent are respectively adjusted by the diameters of the first pipeline 12 and the second pipeline 22. Wherein, the pipe diameter of the first pipe 12 is larger, and the pipe diameter of the second pipe 22 is smaller, so the preheating speed of the first reagent is larger than that of the second reagent.

In addition, the first preheating substrate 11 and the second preheating substrate 21 may also be made of different heat conducting materials according to the difference of the preheating speed between the first reagent and the second reagent, and the first preheating substrate 11 and the second preheating substrate 21 may also be integrally formed, which is not limited in this application.

In an alternative embodiment, the preheating device 100 includes a heat storage base 40 and a heating source, wherein a base mounting portion is provided on the heat storage base 40, a lower end of the second preheating base 21 is mounted on the base mounting portion, the heating source is used for heating the heat storage base 40, the heat storage base 40 transfers heat to the second preheating base 21 and the first preheating base 11 mounted on an upper end of the second preheating base 21, so that the first preheating base 11 and the second preheating base 21 can preheat the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22, respectively.

In an alternative embodiment, the preheating device 100 includes a locking member, the substrate mounting portion is provided with the fixing through-hole 41, the first preheating substrate 11 is provided with the first substrate through-hole 111, and the second preheating substrate 21 is provided with the second substrate through-hole 211. In this embodiment, the first substrate through-holes 111 penetrate through the upper and lower ends of the first preheating substrate 11, and the second substrate through-holes 211 penetrate through the upper and lower ends of the second preheating substrate 21, so that the locking members can be coupled to the fixing through-holes 41 after sequentially penetrating through the first substrate through-holes 111 and the second substrate through-holes 211.

In an alternative embodiment, the locking member includes two bolts, wherein the second substrate through hole 211 is a screw hole provided at the upper end of the second preheating substrate 21, the lower end of the second preheating substrate 21 is provided with a second substrate screw hole 212 so that one of the bolts can be screwed into the second substrate through hole 211 through the first substrate through hole 111, and the other bolt can be screwed into the second substrate screw hole 212 through the fixing through hole 41, so that the first preheating substrate 11, the second preheating substrate 21 and the heat storage substrate 40 can be mounted together in a stacked manner.

After adopting above technical scheme, not only be convenient for first preheating base member 11 and the second shaping processing of preheating base member 21, especially set up first base member helicla flute 112 and the second base member helicla flute 213 of different diameters size on first preheating base member 11 and the second preheating base member 21, can shorten the length of retaining member again simultaneously, effectively improve the intensity of retaining member, also guarantee more easily that first preheating base member 11 and second preheating base member 21 have the preheating temperature of uniformity.

In an alternative embodiment, the preheating device 100 further comprises an adapter tube, so that the first pipeline 12 can be communicated with the second pipeline 22 through the adapter tube, which is not only simple in structure, but also convenient for connecting the two pipelines together.

In an alternative embodiment, the preheating device 100 further comprises a quick coupling, so that the first pipeline 12 can be communicated with the second pipeline 22 through the quick coupling, which is not only simple in structure, but also convenient for connecting the two pipelines together.

In an alternative embodiment, the first reagent is a latex reagent and the second reagent is a hemolysis reagent, wherein the first line 12 is pre-heated by the pressure source 50 delivering the latex reagent to the first line 12; the second line 22 is pre-heated by the pressure source 50 delivering the hemolysis agent to the second line 22; after the preheating of the emulsion reagent in the first line 12 and the hemolytic agent in the second line 22 is completed, the second line 22 transfers the hemolytic agent in the second line 22 to the first line 12 under the action of the pressure source 50, so that the hemolytic agent and the emulsion reagent can be mixed in the first line 12 and then transferred to the reaction tank 200.

As shown in fig. 1 to 18, according to a second aspect of the present application, there is provided a sample analyzer, comprising a liquid storage device, a reaction cell 200, the above preheating device 100, and a sampling device for collecting an analysis sample, wherein the reaction cell 200 is mounted on the sample analyzer, the liquid storage device comprises a first reagent supply device 60 for storing a first reagent and a second reagent supply device 70 for storing a second reagent; the sampling device comprises a sampling needle and a sampling needle driving part for driving the sampling needle to move, wherein the sampling needle driving part drives the sampling needle to collect a sample and distributes the collected sample to the reaction pool.

In this embodiment, one end of the first pipeline 12, which is far away from the second pipeline 22, is divided into two paths, one path is connected to the first reagent liquid supply device 60, the other path is connected to the reaction tank 200, and the other end of the second pipeline 22 is connected to the second reagent liquid supply device 70, so that under the action of the pressure source 50, the first reagent on the first reagent liquid supply device 60 can be conveyed to the first pipeline 12 for preheating, and the second reagent on the second reagent liquid supply device 70 can be conveyed to the second pipeline 22 for preheating by the first pipeline 12 and the second pipeline 22; after preheating of the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22 is completed, the second pipeline 22 delivers the second reagent to the reaction tank 200 through the first pipeline 12 under the action of the pressure source 50; and/or the second reagent is delivered into the first pipeline 12 and is delivered to the reaction cell 200 together with the first reagent in the first pipeline 12.

Specifically, be equipped with a sample loading port 202 and an inlet 201 on reaction cell 200, wherein, the direction of sample loading port 202 is up, inlet 201 and second branch road intercommunication to can make things convenient for the sampling needle will gather the sample and directly add from the sample loading port 202 of reaction cell 200 top, and mix the reaction with leading-in first reagent of inlet 201 and second reagent, then detect the result after sample and reagent reaction through the detection device on reaction cell 200, simple structure is but practical.

In an alternative embodiment, the sample analyzer further comprises a manifold plate 400 disposed between the reaction cell 200 and the preheating device 100, the manifold plate 400 being provided with a liquid outlet end 402 and a liquid inlet end 401, wherein the liquid outlet end 402 is communicated with the liquid inlet 201, and the liquid inlet end 401 is communicated with the second branch, so that the first reagent and/or the second reagent on the first pipeline 12 can be delivered to the reaction cell 200 through the manifold plate 400.

In an alternative embodiment, the sample analyzer further includes a control valve 500, and the control valve 500 is mounted on the manifold 400, so that the flow of the liquid in the first and

second pipes

12 and 22 can be controlled conveniently, and the structure of the sample analyzer can be made more compact.

Specifically, the control valve 500 includes a first control valve 501 and a second control valve 502, wherein the first control valve 501 is connected to the first pipeline 12, the first reagent liquid supply device 60 and the reaction tank 200, respectively, and the second control valve 502 is connected to the second pipeline 22, the pressure source 50 and the second reagent liquid supply device 70, respectively; so that the first reagent in the first reagent supply device 60 enters the first pipeline 12 under the control of the pressure source 50, the first control valve 501 and the second control valve 502, and is preheated in the first pipeline 12; and the second reagent in the second reagent supply device 70 enters the second pipeline 22 under the control of the pressure source 50 and the second control valve 502, and is preheated in the second pipeline 22; after preheating of the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22 is completed, the second reagent in the second pipeline 22 is delivered to the confluence plate 400 through the first pipeline 12 under the control of the pressure source 50, the first control valve 501 and the second control valve 502; and/or the second reagent is delivered into the first pipe 12 and delivered to the manifold 400 together with the first reagent in the first pipe 12.

The first control valve 501 divides the first pipeline 12 into a first branch and a second branch, the second control valve 502 divides the second pipeline 22 into a third branch and a fourth branch, and when the first control valve 501 controls the first pipeline 12 to be communicated with the first branch and the second control valve 502 controls the second pipeline 22 to be communicated with the fourth branch, the first reagent in the first reagent supply device 60 can enter the first pipeline 12 under the control of the pressure source 50; when the second control valve 502 controls the second pipeline 22 to communicate with the third branch, the second reagent in the second reagent supply device 70 can enter the second pipeline 22 under the control of the pressure source 50; after preheating of the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22 is completed, the first control valve 501 controls the first pipeline 12 to communicate with the second branch and the second control valve 502 controls the second pipeline 22 to communicate with the fourth branch, so that the second reagent in the second pipeline 22 can be conveyed to the confluence plate 400 through the first pipeline 12; and/or the second reagent in the second pipeline 22 is delivered to the first pipeline 12 and delivered to the confluence plate 400 together with the first reagent in the first pipeline 12.

In an optional embodiment, the sample analyzer further includes a reaction cell mounting base 300, a fixing base 600 is disposed on one side of the reaction cell mounting base 300 facing the preheating device 100, wherein the bus plate 400 is mounted on the fixing base 600, and the first control valve 501 and the second control valve 502 are both mounted on the bus plate 400, so that the first control valve 501, the second control valve 502, and the bus plate 400 can be mounted between the reaction cell mounting base 300 and the preheating device 100, which not only makes the structure of the sample analyzer more compact, but also facilitates the pipeline arrangement between the preheating device 100, the first control valve 501, the second control valve 502, the bus plate 400, and the reaction cell 200.

In an alternative embodiment, the fixing base 600 is installed at the upper end of the reaction tank mounting base 300, the manifold plate 400 is installed at the lower end of the fixing base 600, and the first control valve 501 and the second control valve 502 are located below the manifold plate, which not only facilitates connection of the first pipeline 12 and the second pipeline 22 with the first control valve 501 and the second control valve 502, but also facilitates communication between the first pipeline 12 and the liquid inlet end 401 and between the liquid outlet end 402 and the reaction tank 200.

In an alternative embodiment, the bottom of the reaction tank mounting base 300 is provided with a base plate 303, wherein the heat storage matrix 40 on the preheating device 100 is in an L-shaped structure. In the present embodiment, the heat storage base fixing portion 43 is provided on the vertical end of the heat storage base, and when the horizontal end of the heat storage base 40 can be placed on the seat plate 303, the heat storage base fixing portion 43 can be fixed on the side wall of the reaction tank installation seat 300, so that the heat storage base 40 can be stably fixed on the reaction tank installation seat 300.

In an alternative embodiment, the thermal storage base 40 is provided with a pipeline through hole 42, and the seat plate 303 is provided with a seat plate through hole 3031, wherein the position of the pipeline through hole 42 corresponds to the position of the seat plate through hole 3031, so that the first pipeline 12 and the second pipeline 22 can pass through the pipeline through hole 42 and the seat plate through hole 3031 and then communicate with the liquid storage device.

In an alternative embodiment, the reaction cell mounting base 300 is provided with a mounting groove having a first opening 301 and a second opening 302, wherein the first opening 301 and the second opening 302 are respectively disposed on two adjacent end surfaces of the reaction cell mounting base 300, when the reaction cell 200 is mounted on the mounting groove through the first opening 301, the sample addition port 202 of the reaction cell 200 faces the direction of the second opening 302, and the liquid inlet port 201 faces the outside of the first opening 301.

In an alternative embodiment, an inlet pipe 203 having an L-shaped structure is connected to the inlet 201, one end of the inlet pipe 203 extends from the first opening 301 to the mounting groove, and the other end of the inlet pipe 203 is connected to the liquid outlet end 402 of the manifold 400.

In this embodiment, inlet 201 sets up in the bottom of reaction tank 200, and inlet pipe 203 is the L type structure of 90 bending, can make things convenient for the reagent on the liquid outflow end 402 to pass through inlet pipe 203 from the leading-in reaction tank 200 of inlet 201 like this in, so not only be convenient for arranging of inlet pipe 203, also make things convenient for reagent can directly mix with the sample in the reaction tank 200 under pressure source 50 control simultaneously, the structure is simple relatively but very practical.

In an alternative embodiment, the reaction well mounting seat further includes a pressing member 700 for fixing the reaction well 200 to the mounting groove.

In an alternative embodiment, the reaction cell mounting seat is further provided with a light emitting device 800 and a receiving device 900, wherein the light emitting device 800 is mounted on one side of the mounting groove, and the receiving device 900 is mounted on the other side of the mounting groove opposite to the light emitting device 800. In this embodiment, the light emitting device 800 can emit light to the reaction cell 200, the receiving device 900 can receive the light scattered from the reaction cell 200 and convert the light into an electrical signal, and the sample analyzer calculates the detection structure and analysis data of the sample according to the electrical signal transmitted by the receiving device 900.

Specifically, after the light emitting device 800 emits light to the reaction cell 200, a part of the light is scattered by the sample molecules or particles inside the reaction cell 200 and then received by the receiving device 900, and the light vertically passing through the reaction cell 200 is transmitted through another channel of the reaction cell mounting base 300 and is not received by the receiving device 900.

In an alternative embodiment, the light incident surface of the mounting groove and the light emitted from the light emitting device 800 to the reaction cell 200 are disposed at an inclined angle.

Specifically, the reaction cell mounting base 300 is provided with a light-emitting channel 304 and a light-entering channel 305, and light generated by the light-emitting device 800 enters the reaction cell 200 through the light-emitting channel 304, is reflected or scattered by the reaction cell 200, and is captured by the receiving device 900 through the light-entering channel 305. In this embodiment, the light-emitting channel 304 and the light-entering channel 305 form an included angle, and the included angle between the light-emitting channel 304 and the light-entering channel 305 is 90-150 °, that is, the light-emitting device 800 emits light to the reaction cell 200, and the light is scattered by the reaction cell 200 and captured by the receiving device 900.

The inclined included angle between the light emitting channel 304 and the light incident surface of the mounting groove is formed, wherein the light incident surface of the mounting groove is a plane on one side of the mounting groove close to the light emitting channel 304, so that the light reflected from the reaction tank 200 can be deviated, the reflected light and the light emitted by the light emitting device 800 are ensured to be different, and therefore the light emitted by the light emitting device 800 is prevented from interfering with the light emitting device 800 due to the reflection of the reaction tank 200.

In the description of the present invention, it should be noted that the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected unless otherwise explicitly stated or limited. Either mechanically or electrically. Either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

The above disclosure provides many different embodiments, or examples, for implementing different features of the invention. The components and arrangements of the specific examples are described above to simplify the present disclosure. Of course, they are merely examples and are not intended to limit the present invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art may recognize applications of other processes and/or uses of other materials.

In the description of the present specification, reference to the description of the terms "one embodiment", "some embodiments", "an illustrative embodiment", "an example", "a specific example", or "some examples", etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A reagent preheating device, comprising:

2. The preheating apparatus according to claim 1, wherein the first conduit is spirally wound around the first preheating substrate and/or the second conduit is spirally wound around the second preheating substrate.

3. The preheater of claim 2, wherein the first preheater substrate defines a first substrate helical groove having a diameter matching a diameter of the first conduit, the first conduit being wound around the first substrate helical groove.

4. The preheating device according to claim 2, wherein the second preheating base is provided with a second base spiral groove, the diameter of the second base spiral groove is matched with that of the second pipeline, and the second pipeline is wound on the second base spiral groove.

5. The preheating device according to any one of claims 1 to 4, wherein the first pipeline and the second pipeline are coated with heat insulation cotton on the outer sides thereof for heat insulation of the first reagent in the first pipeline and the second reagent in the second pipeline.

6. The preheating apparatus according to any one of claims 1 to 5, wherein the first preheating substrate is mounted on an upper end of the second preheating substrate, and a diameter of the first preheating substrate is equal to a diameter of the second preheating substrate.

7. The preheating device according to claim 6, characterized in that the preheating device includes a heat storage base on which a base mounting portion is provided, and a heating source for heating the heat storage base, a lower end of the second preheating base being mounted on the base mounting portion.

8. The preheating device according to claim 7, wherein the preheating device comprises a locking member, the substrate mounting portion is provided with a fixing through hole, the first preheating substrate is provided with a first substrate through hole, the second preheating substrate is provided with a second substrate through hole, and the locking member passes through the first substrate through hole and the second substrate through hole in sequence and then is connected to the fixing through hole.

9. The preheating apparatus according to any one of claims 1 to 8, further comprising an adapter tube, wherein the first line communicates with the second line through the adapter tube.

10. The preheating apparatus according to any one of claims 1 to 8, further comprising a quick coupling, the first line being in communication with the second line through the quick coupling.

11. The preheating device according to any one of claims 1 to 10, wherein the first reagent is an emulsion reagent, the second reagent is a hemolytic reagent, and the first line is used for conveying the emulsion reagent to the first line for preheating under the action of the pressure source; the second pipeline conveys the hemolytic agent to the second pipeline for preheating and then to the first pipeline under the action of the pressure source, and the hemolytic agent and the latex reagent are mixed in the first pipeline and then conveyed to the reaction tank.

12. A sample analyzer, comprising:

the liquid storage device comprises a first reagent liquid supply device for storing a first reagent and a second reagent liquid supply device for storing a second reagent;

after preheating of the first reagent on the first pipeline and the second reagent on the second pipeline is completed, the second pipeline conveys the second reagent to the reaction tank through the first pipeline under the action of the pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to a reaction tank together with the first reagent in the first pipeline.

13. The sample analyzer of claim 12 further comprising a manifold plate disposed between the reaction cell and the preheater device, the manifold plate having a liquid outlet end and a liquid inlet end, the liquid outlet end being in communication with the liquid inlet, the first conduit being routed to the reaction cell via the manifold plate.

14. The sample analyzer of claim 13, further comprising a first control valve and a second control valve, wherein the first control valve is connected to the first conduit, the first reagent supply device and the reaction cell, respectively, and the second control valve is connected to the second conduit, the pressure source and the second reagent supply device, respectively;

15. The sample analyzer of claim 14, further comprising a reaction cell mount, wherein a side of the reaction cell mount facing the preheating device is provided with a fixing seat, the manifold plate is mounted on the fixing seat, and the first control valve and the second control valve are both mounted on the manifold plate.

16. The sample analyzer of claim 15 wherein the mounting block is mounted at an upper end of the reaction cell mounting block, the manifold plate is mounted at a lower end of the mounting block, and the first and second control valves are located below the manifold plate.

17. The sample analyzer as claimed in claim 15, wherein a base plate is provided at the bottom of the reaction tank mounting seat, the heat storage base on the preheating device is in an L-shaped structure, the horizontal end of the heat storage base is placed on the base plate, and the vertical end of the heat storage base is fixed on the side wall of the reaction tank mounting seat.

18. The sample analyzer as claimed in claim 17, wherein a pipeline through hole is formed in the heat storage base body, a seat plate through hole is formed in the seat plate, and the position of the pipeline through hole corresponds to the position of the seat plate through hole, so that the first pipeline and the second pipeline can be communicated with the liquid storage device after passing through the pipeline through hole and the seat plate through hole.

19. The sample analyzer of claim 15, wherein the reaction cell mounting seat is provided with a mounting groove, the mounting groove has a first opening and a second opening, the first opening and the second opening are respectively disposed on two adjacent end surfaces of the reaction cell mounting seat, the reaction cell is mounted on the mounting groove through the first opening, the sample injection port of the reaction cell faces the direction of the second opening, and the liquid inlet faces the outer side of the first opening.

20. The sample analyzer as claimed in claim 19, wherein the liquid inlet is connected to a liquid inlet pipe having an L-shaped structure, one end of the liquid inlet pipe extends from the first opening to the mounting groove, and the other end of the liquid inlet pipe is connected to the manifold plate.

21. The sample analyzer of claim 19, wherein the reaction cell mount is further provided with:

22. The sample analyzer as claimed in claim 21, wherein the light incident surface of the mounting groove and the light emitted from the light emitting device to the reaction cell are arranged at an inclined included angle.