CN113018568A - Cell back transfusion device for cell biotherapy - Google Patents
Cell back transfusion device for cell biotherapy Download PDFInfo
- Publication number
- CN113018568A CN113018568A CN202110222228.5A CN202110222228A CN113018568A CN 113018568 A CN113018568 A CN 113018568A CN 202110222228 A CN202110222228 A CN 202110222228A CN 113018568 A CN113018568 A CN 113018568A
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- Prior art keywords
- rod
- cell
- fixedly connected
- support
- bearing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000001815 biotherapy Methods 0.000 title claims abstract description 21
- 230000001413 cellular effect Effects 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 3
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 5
- 238000002659 cell therapy Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1414—Hanging-up devices
- A61M5/1415—Stands, brackets or the like for supporting infusion accessories
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1412—Burettes, measuring cylinders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1414—Hanging-up devices
- A61M5/1417—Holders or handles for hanging up infusion containers
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a cell feedback device for cell biotherapy, wherein an inner rod is positioned inside an outer rod, a lifting component is positioned on the side edge of the outer rod, a swinging component is positioned above the inner rod, a fixed box is positioned above the inner rod, a support is positioned inside the fixed box, an air cylinder is positioned inside the support, one end of an extension rod is fixedly connected with the output end of the air cylinder, the other end of the extension rod penetrates through the support and is fixedly connected with a bearing, a placing frame is fixedly connected with the bearing and is positioned on the side edge of the bearing, one end of a support rod is fixedly connected with the placing frame, the other end of the support rod penetrates through the support, the cell feedback device for cell biotherapy can uniformly shake a cell solution and is not easy to generate precipitates, and manpower is saved, thereby improving the treatment effect on patients.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a cell reinfusion device for cell biotherapy.
Background
The cell therapy technology is that human body cells which are normal or bioengineered are transplanted or input into a patient body, and the newly input cells can replace, repair damaged cells or stimulate and regulate an immune system, so that the cell therapy technology has a stronger immune killing function, and the aim of treating diseases is fulfilled.
Cell feedback is an important link in cell therapy technology, and at present, cell feedback bags are mostly adopted for cell feedback, however, due to the biological characteristics of cells, cells in feedback suspension are easy to agglomerate or stick to the inner wall of the cell feedback bag, so that the cells in the cell feedback bags cannot be completely fed back to patients, cell waste is caused, and medical accidents are caused by blockage of blood vessels due to cell agglomerates. Under the current medical condition, in the process of cell back transfusion, the medical staff frequently shakes the cell solution, the labor is consumed, and when the cell transfusion is carried out on the patient, the cell is easy to precipitate due to long-time standing, so that the treatment effect of the patient is influenced.
Disclosure of Invention
The invention aims to provide a cell reinfusion device for cell biotherapy, and aims to solve the technical problems that in the cell reinfusion process in the prior art, most medical workers frequently shake cell solution to consume manpower, and when cell transfusion is carried out on a patient, the cell is easy to precipitate due to long-time standing, so that the treatment effect of the patient is influenced.
In order to achieve the above object, the cell feedback device for cell biotherapy in the invention comprises an outer rod, an inner rod, a lifting component and a swinging component, wherein the inner rod is movably connected with the outer rod and is positioned in the outer rod, the lifting component is fixedly connected with the outer rod and is positioned at the side edge of the outer rod, the swinging component is fixedly connected with the inner rod and is positioned above the inner rod, the swinging component comprises a fixed box, a support, a cylinder, an extension rod, a bearing, a placing frame and a support rod, the fixed box is fixedly connected with the inner rod and is positioned above the inner rod, the support is fixedly connected with the fixed box and is positioned in the fixed box, the cylinder is fixedly connected with the support and is positioned in the support, one end of the extension rod is fixedly connected with the output end of the cylinder, the other end of extension rod runs through the support, and with bearing fixed connection, place the frame with bearing fixed connection, and be located the side of bearing, the one end of bracing piece with place frame fixed connection, the other end of bracing piece runs through the support.
The swing assembly further comprises a fixture block, and the fixture block is fixedly connected with the supporting rod and is located inside the support.
Wherein, lifting unit includes fixing base, spring, dead lever and locking cap, the lateral wall of interior pole has a plurality of hole grooves, the fixing base with interior pole fixed connection, and be located the side of interior pole, the spring set up in the inside of fixing base, the dead lever runs through the fixing base, and with hole groove looks adaptation, the locking cap with dead lever fixed connection, and be located the side of outer pole.
The lifting assembly further comprises a protection pad, and the protection pad is fixedly connected with the fixing rod and located on the side edge of the outer rod.
The cell reinfusion device for cell biotherapy further comprises a support, wherein the support is fixedly connected with the outer rod and is positioned below the outer rod.
The cell reinfusion device for cell biotherapy further comprises a universal wheel, wherein the universal wheel is fixedly connected with the support and is positioned below the support.
The invention has the beneficial effects that: the inner rod is arranged in the outer rod through the inner rod, the lifting component is arranged on the side edge of the outer rod, the swinging component is arranged above the inner rod, the lifting component can lift the inner rod from the inner part of the outer rod, a bag filled with cells is placed in the placing frame of the swinging component, after the cell bag is placed, the fixing box fixes the cell bag, the cylinder in the support is started, the extending rod fixedly connected with the cylinder is extended by the output end of the cylinder, the extending rod penetrates through the support and is fixedly connected with the bearing, the bearing is fixedly connected with the placing frame through the extending rod, the side edge of the placing frame is lifted, the other side of the placing frame is pressed down, and the supporting rod arranged on the side edge of the bearing assists the placing frame, the bracing piece just inserts the inside of support, right place the frame and assist, be equipped with the cell bag place the frame, along with the operation of cylinder just will place the inside cell bag of frame and swing, use manpower sparingly, when carrying out the cell infusion to the patient in addition, just be difficult for producing the sediment to improve the treatment to the patient.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a cell transfusion device for cell biotherapy according to the present invention.
FIG. 2 is a side view of a cell reinfusion device for cellular biotherapy according to the present invention.
Fig. 3 is a cross-sectional view of the a-a line structure of fig. 2 of the present invention.
FIG. 4 is a front view of a cell transfusion device for cell biotherapy according to the present invention.
Fig. 5 is a cross-sectional view of the B-B line structure of fig. 4 in accordance with the present invention.
Fig. 6 is a partial enlarged view at C of fig. 3 of the present invention.
1-outer rod, 2-inner rod, 3-lifting component, 31-fixing seat, 32-spring, 33-fixing rod, 34-fixing cap, 35-hole groove, 4-swinging component, 41-fixing box, 42-support, 43-cylinder, 44-extension rod, 45-bearing, 46-placing frame, 47-support rod, 5-fixture block, 6-protective pad, 7-support, 8-universal wheel, 9-hook, 10-dropping bottle and 11-dropping pipe.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, and are used merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. Further, in the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Referring to fig. 1 to 6, the present invention provides a cell feedback device for cell biotherapy, including an outer rod 1, an inner rod 2, a lifting component 3 and a swinging component 4, wherein the inner rod 2 is movably connected with the outer rod 1 and is located inside the outer rod 1, the lifting component 3 is fixedly connected with the outer rod 1 and is located at a side edge of the outer rod 1, the swinging component 4 is fixedly connected with the inner rod 2 and is located above the inner rod 2, the swinging component 4 includes a fixed box 41, a support 42, a cylinder 43, an extension rod 44, a bearing 45, a placing frame 46 and a support rod 47, the fixed box 41 is fixedly connected with the inner rod 2 and is located above the inner rod 2, the support 42 is fixedly connected with the fixed box 41 and is located inside the fixed box 41, the cylinder 43 is fixedly connected with the support 42, and be located support 42's inside, extension rod 44's one end with cylinder 43's output fixed connection, extension rod 44's the other end runs through support 42, and with bearing 45 fixed connection, place frame 46 with bearing 45 fixed connection, and be located bearing 45's side, the one end of bracing piece 47 with place frame 46 fixed connection, the other end of bracing piece 47 runs through support 42.
In this embodiment, the inner rod 2 is disposed inside the outer rod 1, the lifting component 3 is disposed at a side of the outer rod 1, the swing component 4 is disposed above the inner rod 2, the lifting component 3 can lift the inner rod 2 from the inner portion of the outer rod 1, a bag with cells is placed inside the placing frame 46 of the swing component 4, after the cell bag is placed, the fixing box 41 fixes the cell bag, the cylinder 43 inside the support 42 is started, the output end of the cylinder 43 extends the extension rod 44 fixedly connected with the cylinder 43, the extension rod 44 penetrates the support 42 and is fixedly connected with the bearing 45, the bearing 45 lifts the side of the placing frame 46 along with the extension rod 44 and the placing frame 46 fixedly connected with the bearing 45, accordingly, the other side of the placing frame 46 is pressed down, the supporting rod 47 provided at the side of the bearing 45 assists the placing frame 46, the supporting rod 47 is inserted into the inside of the support 42 to assist the placing frame 46, and the placing frame 46 with the cell bag swings the cell bag inside the placing frame 46 along with the operation of the cylinder 43, so that the cell bag is not easily deposited when the cell transfusion is performed on the patient, thereby improving the therapeutic effect on the patient.
Further, the swing assembly 4 further includes a fixture block 5, and the fixture block 5 is fixedly connected to the support rod 47 and is located inside the support 42.
In this embodiment, the fixture 5 is disposed below the supporting rod 47, and when the supporting rod 47 is lifted, the fixture 5 can clamp the supporting rod 47 in the support 42, fix the supporting rod 47, and assist the operation of the supporting rod 47.
Further, lifting unit 3 includes fixing base 31, spring 32, dead lever 33 and locking cap 34, the lateral wall of interior pole 2 has a plurality of hole grooves 35, fixing base 31 with interior pole 2 fixed connection, and be located the side of interior pole 2, spring 32 set up in the inside of fixing base 31, dead lever 33 runs through fixing base 31, and with hole grooves 35 looks adaptation, locking cap 34 with dead lever 33 fixed connection, and be located the side of outer pole 1.
In this embodiment, the lifting assembly 3 is disposed at a side of the outer rod 1, a plurality of hole slots 35 are disposed at a side wall of the inner rod 2, the plurality of hole slots 35 are respectively adapted to the fixing rod 33 of the lifting assembly 3, the fixing seat 31 of the lifting assembly 3 is disposed at a side of the inner rod 2, the spring 32 is disposed inside the fixing seat 31, the fixing rod 33 penetrates through the fixing seat 31, the spring 32 is sleeved outside the fixing rod 33, the spring 32 can assist the fixing rod 33 to reset, the fixing cap 34 is disposed at a side of the fixing rod 33, a medical worker can pull the fixing rod 33 fixedly connected with the fixing cap 34 by pulling the fixing cap 34, and accordingly, the inner rod 2 is stretched, and the inner rod 2 is adjusted inside the outer rod 1, and lifting the inner rod 2.
Further, the lifting assembly 3 further comprises a protection pad 6, and the protection pad 6 is fixedly connected with the fixing rod 33 and is located on the side of the outer rod 1.
In this embodiment, the protection pad 6 is disposed at a side of the outer rod 1, and when the fixing rod 33 is stretched, the protection pad 6 can protect the outer rod 1 and prolong a service life of the fixing rod 33.
Further, the cell reinfusion device for cell biotherapy further comprises a bracket 7, wherein the bracket 7 is fixedly connected with the outer rod 1 and is positioned below the outer rod 1.
In the present embodiment, the bracket 7 is provided below the outer rod 1, and can support the outer rod 1, assist the outer rod 1, and prolong the service life of the outer rod 1.
Further, the cell reinfusion device for cell biotherapy further comprises a universal wheel 8, wherein the universal wheel 8 is fixedly connected with the support 7 and is positioned below the support 7.
In this embodiment, the universal wheel 8 is disposed below the support 7, and the universal wheel 8 can drive the support 7 fixedly connected thereto, and accordingly, the outer rod 1 fixedly connected to the support 7 can be driven, so that the patient can move through the position of the patient when performing cell transfusion, thereby facilitating the use.
Furthermore, cell feedback device for cell biotherapy still includes couple 9, couple 9 with interior pole 2 fixed connection to be located the side of interior pole 2.
In this embodiment, the hook 9 is disposed at the side of the inner rod 2, and the hook 9 can assist medical staff, facilitate hanging of the medicine bottle and facilitate operation of the medical staff.
Further, the cell reinfusion device for cell biotherapy further comprises a dropping bottle 10, wherein the dropping bottle 10 is movably connected with the hook 9 and is positioned above the hook 9.
In this embodiment, the dropping bottle 10 is arranged above the hook 9, and the dropping bottle 10 is hung above the hook 9, so that when a patient needs to additionally increase the injection of the medicine, the medicine can be injected through the dropping bottle 10, and the medicine is safer and is not easy to be subjected to secondary pollution.
Further, the cell reinfusion device for cell biotherapy further comprises a dropping pipe 11, wherein the dropping pipe 11 is fixedly connected with the dropping bottle 10 and is positioned below the dropping bottle 10.
In this embodiment, the dropping pipe 11 set up in the below of dropping bottle 10, through dropping bottle 10 pours into dropping pipe 11, dropping pipe 11 can carry out the regulation of infusion speed with the liquid medicine, can ensure that patient's health is adjusted, and is more convenient.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (6)
1. A cell return device for cell biotherapy is characterized in that,
comprises an outer rod, an inner rod, a lifting component and a swinging component, wherein the inner rod is movably connected with the outer rod and is positioned in the outer rod, the lifting component is fixedly connected with the outer rod and is positioned on the side edge of the outer rod, the swinging component is fixedly connected with the inner rod and is positioned above the inner rod, the swinging component comprises a fixed box, a support, a cylinder, an extension rod, a bearing, a placing frame and a support rod, the fixed box is fixedly connected with the inner rod and is positioned above the inner rod, the support is fixedly connected with the fixed box and is positioned in the fixed box, the cylinder is fixedly connected with the support and is positioned in the support, one end of the extension rod is fixedly connected with the output end of the cylinder, the other end of the extension rod penetrates through the support and is fixedly connected with the bearing, the placing frame is fixedly connected with the bearing and positioned on the side edge of the bearing, one end of the supporting rod is fixedly connected with the placing frame, and the other end of the supporting rod penetrates through the support.
2. The cellular biotherapeutic cell reinfusion device of claim 1,
the swing assembly further comprises a fixture block, and the fixture block is fixedly connected with the supporting rod and is located inside the support.
3. The cellular biotherapeutic cell reinfusion device of claim 1,
the lifting component comprises a fixing seat, a spring, a fixing rod and a fixing cap, the side wall of the inner rod is provided with a plurality of hole grooves, the fixing seat is fixedly connected with the inner rod and is located at the side edge of the inner rod, the spring is arranged in the fixing seat, the fixing rod penetrates through the fixing seat and is matched with the hole grooves, and the fixing cap is fixedly connected with the fixing rod and is located at the side edge of the outer rod.
4. The cellular biotherapeutic cell reinfusion device according to claim 3,
the lifting assembly further comprises a protection pad, and the protection pad is fixedly connected with the fixed rod and located on the side edge of the outer rod.
5. The cellular biotherapeutic cell reinfusion device of claim 1,
the cell reinfusion device for cell biotherapy further comprises a support, wherein the support is fixedly connected with the outer rod and is positioned below the outer rod.
6. The cellular biotherapeutic cell reinfusion device according to claim 5, wherein,
the cell reinfusion device for cell biotherapy further comprises a universal wheel, wherein the universal wheel is fixedly connected with the support and is positioned below the support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110222228.5A CN113018568A (en) | 2021-02-28 | 2021-02-28 | Cell back transfusion device for cell biotherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110222228.5A CN113018568A (en) | 2021-02-28 | 2021-02-28 | Cell back transfusion device for cell biotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113018568A true CN113018568A (en) | 2021-06-25 |
Family
ID=76466241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110222228.5A Pending CN113018568A (en) | 2021-02-28 | 2021-02-28 | Cell back transfusion device for cell biotherapy |
Country Status (1)
| Country | Link |
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| CN (1) | CN113018568A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105935572A (en) * | 2016-07-14 | 2016-09-14 | 苏州睿绮电子有限公司 | Swing type automatic solution mixing structure |
| CN108273147A (en) * | 2018-04-02 | 2018-07-13 | 姜有维 | A kind of anti-condensation oscillator of clinic autotransfusion |
| CN110215559A (en) * | 2019-04-16 | 2019-09-10 | 广州市婵昕生物科技有限责任公司 | A kind of portable type infusion device with regulatory function for biological diagnosis and treatment |
| CN110237344A (en) * | 2019-04-10 | 2019-09-17 | 广州市婵昕生物科技有限责任公司 | A kind of stable type infusion device with oscillating function for biological diagnosis and treatment |
| CN110433351A (en) * | 2019-08-05 | 2019-11-12 | 深圳市普特生物医学工程有限公司 | Oscillating uniform device and blood component separator |
| US20190365988A1 (en) * | 2016-05-25 | 2019-12-05 | Dongkoo Bio & Pharma Co., Ltd. | Medical injection device |
| CN209797972U (en) * | 2019-01-21 | 2019-12-17 | 陈龙 | A3D cell culture device for studying tumour is shifted |
| CN112113644A (en) * | 2020-08-27 | 2020-12-22 | 清远市沃尔森医用科技有限公司 | Arc sways formula blood sampling balance |
-
2021
- 2021-02-28 CN CN202110222228.5A patent/CN113018568A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190365988A1 (en) * | 2016-05-25 | 2019-12-05 | Dongkoo Bio & Pharma Co., Ltd. | Medical injection device |
| CN105935572A (en) * | 2016-07-14 | 2016-09-14 | 苏州睿绮电子有限公司 | Swing type automatic solution mixing structure |
| CN108273147A (en) * | 2018-04-02 | 2018-07-13 | 姜有维 | A kind of anti-condensation oscillator of clinic autotransfusion |
| CN209797972U (en) * | 2019-01-21 | 2019-12-17 | 陈龙 | A3D cell culture device for studying tumour is shifted |
| CN110237344A (en) * | 2019-04-10 | 2019-09-17 | 广州市婵昕生物科技有限责任公司 | A kind of stable type infusion device with oscillating function for biological diagnosis and treatment |
| CN110215559A (en) * | 2019-04-16 | 2019-09-10 | 广州市婵昕生物科技有限责任公司 | A kind of portable type infusion device with regulatory function for biological diagnosis and treatment |
| CN110433351A (en) * | 2019-08-05 | 2019-11-12 | 深圳市普特生物医学工程有限公司 | Oscillating uniform device and blood component separator |
| CN112113644A (en) * | 2020-08-27 | 2020-12-22 | 清远市沃尔森医用科技有限公司 | Arc sways formula blood sampling balance |
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Application publication date: 20210625 |