CN209797972U - A3D cell culture device for studying tumour is shifted - Google Patents
A3D cell culture device for studying tumour is shifted Download PDFInfo
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- CN209797972U CN209797972U CN201920094373.8U CN201920094373U CN209797972U CN 209797972 U CN209797972 U CN 209797972U CN 201920094373 U CN201920094373 U CN 201920094373U CN 209797972 U CN209797972 U CN 209797972U
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- culture dish
- screw thread
- cell culture
- motor
- rotating shaft
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Abstract
The utility model relates to the field of biotechnology, specifically be a 3D cell culture device for studying tumour shifts, including box, case lid, backup pad, lug, culture dish, first articulated seat, backup pad, cylinder, telescopic shaft, first motor, install two fixed blocks along central symmetry on the inside diapire of box, install the regulating spindle between two fixed blocks, two screw thread portions have been seted up on the regulating spindle, two screw thread portions set up along the central symmetry of regulating spindle, and two screw thread portions on the screw thread are opposite to be set up, all install the swivel nut in the screw thread portion. The culture dish can be obliquely shaken by matching the air cylinder with the telescopic shaft, so that the culture solution in the culture dish can be uniformly flattened; the rotating shaft can drive the supporting plate to rotate relative to the lifting plate, so that the angle of the culture dish is adjusted; carry out horizontal adjustment to the swivel nut through the cooperation of screw thread portion and swivel nut, the swivel nut rethread connecting rod carries out lift adjustment to the lifter plate, finally realizes the altitude mixture control to the culture dish in the backup pad.
Description
Technical Field
The utility model relates to the field of biotechnology, specifically be a 3D cell culture device for studying tumor metastasis.
Background
The normal term in biology for cell cloning technology is cell culture technology. Cell culture is an indispensable process for both the whole bioengineering technology and one of the biological cloning technologies, the cell culture is a large-scale clone of cells, and the cell culture technology can be used for making simple single cells or cells with few differentiations from one cell through mass culture, which is an indispensable link of the cloning technology.
The traditional cell culture technology needs a cell culture device, most of the cell culture devices are culture dish appliances, most of the traditional culture dishes are independent glass ware bodies, and the operations of shaking, rotating and the like of later culture require additional instruments for auxiliary operation, which is very troublesome.
SUMMERY OF THE UTILITY MODEL
an object of the utility model is to provide a 3D cell culture device for studying tumour metastasis to solve the problem that proposes in the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme: A3D cell culture device for researching tumor metastasis comprises a box body, wherein the upper end of the box body is open, a box cover is installed at the opening in a matched mode, a horizontally arranged supporting plate is arranged inside the box body, a convex block is installed at the center of the upper end of the supporting plate, a culture dish is arranged above the supporting plate, a first hinged seat is installed at the center of the lower end of the culture dish, the lower end of the first hinged seat is installed on the convex block, the left side of the lower end of the culture dish is installed on the supporting plate through a supporting spring, an air cylinder is installed on the right side of the upper end of the supporting plate in an embedded mode, a telescopic shaft is arranged at the upper end of the air cylinder, the top end of the telescopic shaft is hinged to the lower side of the culture dish, a lifting plate is further arranged in the box body and is arranged under the supporting plate, one side that lies in the pivot on the lifter plate inlays to establish and installs first motor, and the driving gear is installed to the output shaft upper end of first motor, and the driving gear meshes with driven gear mutually, install two fixed blocks along central symmetry on the inside diapire of box, install the regulating spindle between two fixed blocks, two screw thread portions have been seted up on the regulating spindle, and two screw thread portions set up along the central symmetry of regulating spindle, and two screw thread opposite settings in portion, all install the swivel nut in the screw thread portion, the articulated seat of second is installed to the upper end of swivel nut, and the third articulated seat is installed to the lower extreme bilateral symmetry of lifter plate, all is connected through the connecting rod between the articulated seat of second that is close to each other and the third articulated seat.
Preferably, the first motor is externally sleeved with a damping sleeve.
Preferably, the support frame is installed to the lower extreme avris of backup pad, and the pulley is installed to the lower extreme of support frame, and the ring channel has been seted up to the upper end avris of lifter plate, and the lower extreme of pulley is all slided and is located in the ring channel.
preferably, a rotating shaft mounting groove is formed in the center of the upper end of the lifting plate, and a motor mounting groove is formed in one side of the rotating shaft mounting groove.
Preferably, one end of the adjusting shaft is connected with a second motor, and the second motor is installed between the fixed block on one side and the inner side wall of the box body.
Preferably, the sliding blocks are symmetrically arranged on the side wall of the lifting plate, the sliding grooves are symmetrically formed in the inner side wall of the box body, and the end portions of the sliding blocks are arranged in the sliding grooves in a sliding mode.
Preferably, the guide block is installed to the lower extreme of swivel nut, has seted up the guide slot on the inside diapire of box, and the guide slot is equipped with two, and two guide slots are located two screw thread portions under, and the guide slot is parallel with screw thread portion, and the lower extreme of guide block slides and establishes with in the guide slot.
Compared with the prior art, the beneficial effects of the utility model are that:
1. The culture dish can be obliquely shaken by matching the air cylinder with the telescopic shaft, and the culture solution in the culture dish can be uniformly flattened by the repeated operation of the air cylinder;
2. The driving gear is driven to rotate by the first motor, the driving gear drives the rotating shaft to rotate by the driven gear, and the rotating shaft can drive the supporting plate to rotate relative to the lifting plate so as to adjust the angle of the culture dish;
3. Carry out horizontal adjustment to the swivel nut through the cooperation of screw thread portion and swivel nut, the swivel nut rethread connecting rod carries out lift adjustment to the lifter plate, finally realizes the altitude mixture control to the culture dish in the backup pad.
Drawings
FIG. 1 is a schematic diagram of a 3D cell culture apparatus for studying tumor metastasis;
FIG. 2 is a schematic diagram of the structure of a lifting plate in a 3D cell culture device for studying tumor metastasis.
In the figure: the culture dish support comprises a box body 1, a cover plate 2, a support plate 3, a convex block 4, a culture dish 5, a first hinged seat 6, a support spring 7, a cylinder 8, a telescopic shaft 9, a lifting plate 10, a bearing 11, a rotating shaft 12, a driven gear 13, a first motor 14, a driving gear 15, a damping sleeve 16, a support frame 17, a pulley 18, an annular groove 19, a rotating shaft installation groove 20, a motor installation groove 21, a fixed block 22, an adjusting shaft 23, a threaded part 24, a threaded sleeve 25, a second hinged seat 26, a third hinged seat 27, a connecting rod 28, a second motor 29, a sliding block 30, a sliding groove 31, a guide block 32 and a guide groove 33.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1 to 2, the present invention provides a technical solution: A3D cell culture device for studying tumor metastasis comprises a box body 1, the upper end of the box body 1 is open, a box cover 2 is installed at the opening in a matched mode, a horizontally arranged supporting plate 3 is arranged inside the box body 1, a convex block 4 is installed at the center of the upper end of the supporting plate 3, a culture dish 5 is arranged above the supporting plate 3, a first hinged seat 6 is installed at the center of the lower end of the culture dish 5, the lower end of the first hinged seat 6 is installed on the convex block 4, the left side of the lower end of the culture dish 5 is installed on the supporting plate 3 through a supporting spring 7, a cylinder 8 is installed on the right side of the upper end of the supporting plate 3 in an embedded mode, a telescopic shaft 9 is arranged at the upper end of the cylinder 8, the top end of the telescopic shaft 9 is hinged to the lower side of the culture dish 5, the culture dish 5 can be tilted and shaken, the incubator is characterized in that a lifting plate 10 is further arranged in the incubator body 1, the lifting plate 10 is arranged under the support plate 3, a rotating shaft 12 is arranged at the center of the upper end of the lifting plate 10 through a bearing 11, the top end of the rotating shaft 12 is fixedly arranged at the center of the lower end of the support plate 3, a driven gear 13 is arranged on the rotating shaft 12, a first motor 14 is embedded and arranged on one side, located on the rotating shaft 12, of the lifting plate 10, a driving gear 15 is arranged at the upper end of an output shaft of the first motor 14, the driving gear 15 is meshed with the driven gear 13, the driving gear 15 is driven to rotate through the first motor 14, the driving gear 15 drives the rotating shaft 12 to rotate through the driven gear 13, the rotating shaft 12 can drive the support plate 3 to rotate relative to the lifting plate 10 to adjust the angle of the culture dish 5, two fixing blocks 22, two screw thread portions 24 have been seted up on regulating shaft 23, two screw thread portions 24 set up along the central symmetry of regulating shaft 23, and the opposite setting of screw thread on two screw thread portions 24, all install swivel nut 25 on the screw thread portion 24, the articulated seat of second 26 is installed to the upper end of swivel nut 25, third articulated seat 27 is installed to the lower extreme bilateral symmetry of lifter plate 10, all be connected through connecting rod 28 between the articulated seat of second 26 that are close to each other and the third articulated seat 27, come to carry out horizontal adjustment to swivel nut 25 through screw thread portion 24 and swivel nut 25's cooperation, swivel nut 25 rethread connecting rod 28 carries out lifting control to lifter plate 10, the final realization is to the altitude mixture control of culture dish 5 in backup pad 3.
Further, the damping sleeve 16 is sleeved outside the first motor 14, so that the stability of the first motor 14 can be ensured, and too much vibration cannot be caused to the lifting plate 10.
Furthermore, a support frame 17 is installed on the lower end edge side of the support plate 3, a pulley 18 is installed on the lower end of the support frame 17, an annular groove 19 is formed in the upper end edge side of the lifting plate 10, and the lower end of the pulley 18 is arranged in the annular groove 19 in a sliding mode. The arrangement of the pulley 18 and the annular groove 19 ensures stability in the rotational adjustment of the support plate 3.
Further, a rotating shaft installation groove 20 is formed in the center of the upper end of the lifting plate 10, and a motor installation groove 21 is installed at one side of the rotating shaft installation groove 20.
Further, one end of the adjusting shaft 23 is connected with a second motor 29, and the second motor 29 is installed between the fixing block 22 on one side and the inner side wall of the box body 1.
Further, the side wall of the lifting plate 10 is symmetrically provided with the sliding blocks 30, the inner side wall of the box body 1 is symmetrically provided with the sliding grooves 31, and the end parts of the sliding blocks 30 are arranged in the sliding grooves 31 in a sliding manner. The stable lifting of the lifting plate 10 can be ensured by the cooperation of the sliding block 30 and the sliding groove 31.
Furthermore, a guide block 32 is installed at the lower end of the threaded sleeve 25, two guide grooves 33 are formed in the bottom wall of the interior of the box body 1, the two guide grooves 33 are respectively arranged right below the two threaded portions 24, the guide grooves 33 are parallel to the threaded portions 24, and the lower end of the guide block 32 is slidably arranged in the guide grooves 33. The arrangement of the guide groove 33 and the guide block 32 can ensure that the screw sleeve 25 does not rotate along with the threaded portion 24.
the working principle is as follows: can incline to rock culture dish 5 through 8 cooperation telescopic shafts 9 of cylinder, the function alright of relapseing of cylinder is with realizing evenly shakeout to culture solution in the culture dish 5, it is rotatory to drive driving gear 15 through first motor 14, driving gear 15 rethread drive pivot 12 rotations from driving gear 13, pivot 12 alright rotate for lifter plate 10 with driving backup pad 3, adjust culture dish 5's angle, come to carry out horizontal adjustment to swivel nut 25 through screw thread portion 24 and swivel nut 25's cooperation, swivel nut 25 rethread connecting rod 28 carries out lifting adjustment to lifter plate 10, finally the realization is to the altitude mixture control of culture dish 5 in the backup pad 3.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A3D cell culture device for studying tumor metastasis, comprising a case (1), characterized in that: the box is characterized in that the upper end of the box body (1) is opened, a box cover (2) is installed at the opening in a matched mode, a horizontally arranged supporting plate (3) is arranged inside the box body (1), a convex block (4) is installed at the center of the upper end of the supporting plate (3), a culture dish (5) is arranged above the supporting plate (3), a first hinged seat (6) is installed at the center of the lower end of the culture dish (5), the lower end of the first hinged seat (6) is installed on the convex block (4), the left side of the lower end of the culture dish (5) is installed on the supporting plate (3) through a supporting spring (7), an air cylinder (8) is embedded and installed on the right side of the upper end of the supporting plate (3), a telescopic shaft (9) is arranged at the upper end of the air cylinder (8), the top end of the telescopic shaft (9) is hinged to the lower side of the culture dish (, a rotating shaft (12) is installed in the center of the upper end of a lifting plate (10) through a bearing (11), the top end of the rotating shaft (12) is fixedly installed on the center of the lower end of a supporting plate (3), a driven gear (13) is installed on the rotating shaft (12), a first motor (14) is installed on one side, located on the rotating shaft (12), of the lifting plate (10) in an embedded mode, a driving gear (15) is installed at the upper end of an output shaft of the first motor (14), the driving gear (15) is meshed with the driven gear (13), two fixing blocks (22) are installed on the inner bottom wall of a box body (1) along the central symmetry, an adjusting shaft (23) is installed between the two fixing blocks (22), two thread portions (24) are formed in the adjusting shaft (23), the two thread portions (24) are symmetrically arranged along the center of the adjusting shaft (23), threads on the two thread portions (24) are oppositely arranged, and, the upper end of the threaded sleeve (25) is provided with a second hinged seat (26), the lower end of the lifting plate (10) is provided with third hinged seats (27) in bilateral symmetry, and the second hinged seat (26) and the third hinged seat (27) which are close to each other are connected through a connecting rod (28).
2. A 3D cell culture apparatus for studying tumor metastasis according to claim 1, wherein: the outside cover of first motor (14) is equipped with shock attenuation cover (16).
3. A 3D cell culture apparatus for studying tumor metastasis according to claim 1, wherein: support frame (17) are installed to the lower extreme avris of backup pad (3), and pulley (18) are installed to the lower extreme of support frame (17), and ring channel (19) have been seted up to the upper end avris of lifter plate (10), and the lower extreme of pulley (18) is all slided and is located in ring channel (19).
4. A 3D cell culture apparatus for studying tumor metastasis according to claim 1, wherein: a rotating shaft mounting groove (20) is formed in the center of the upper end of the lifting plate (10), and a motor mounting groove (21) is mounted on one side of the rotating shaft mounting groove (20).
5. A 3D cell culture apparatus for studying tumor metastasis according to claim 1, wherein: one end of the adjusting shaft (23) is connected with a second motor (29), and the second motor (29) is installed between the fixed block (22) on one side and the inner side wall of the box body (1).
6. a 3D cell culture apparatus for studying tumor metastasis according to claim 1, wherein: the side wall of the lifting plate (10) is symmetrically provided with sliding blocks (30), the inner side wall of the box body (1) is symmetrically provided with sliding grooves (31), and the end parts of the sliding blocks (30) are arranged in the sliding grooves (31) in a sliding mode.
7. A 3D cell culture apparatus for studying tumor metastasis according to claim 1, wherein: guide block (32) are installed to the lower extreme of swivel nut (25), have seted up guide slot (33) on the inside diapire of box (1), and guide slot (33) are equipped with two, and two guide slot (33) are located two screw thread portion (24) respectively under, and guide slot (33) and screw thread portion (24) parallel, and the lower extreme of guide block (32) slides and establishes in guide slot (33).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920094373.8U CN209797972U (en) | 2019-01-21 | 2019-01-21 | A3D cell culture device for studying tumour is shifted |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920094373.8U CN209797972U (en) | 2019-01-21 | 2019-01-21 | A3D cell culture device for studying tumour is shifted |
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| Publication Number | Publication Date |
|---|---|
| CN209797972U true CN209797972U (en) | 2019-12-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920094373.8U Expired - Fee Related CN209797972U (en) | 2019-01-21 | 2019-01-21 | A3D cell culture device for studying tumour is shifted |
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| CN (1) | CN209797972U (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111621421A (en) * | 2020-06-16 | 2020-09-04 | 浙江省肿瘤医院 | Tumor cell culture device |
| CN112608840A (en) * | 2020-12-16 | 2021-04-06 | 李娄 | Novel adjustable cell culture dish frame |
| CN113018568A (en) * | 2021-02-28 | 2021-06-25 | 南京帝基生物科技有限公司 | Cell back transfusion device for cell biotherapy |
| CN113150990A (en) * | 2021-05-15 | 2021-07-23 | 黄韶平 | Cell culture dish |
| CN118530839A (en) * | 2024-07-26 | 2024-08-23 | 中科南京生命健康高等研究院 | Cell culture reactor |
| CN118580952A (en) * | 2024-07-24 | 2024-09-03 | 江苏奕农生物股份有限公司 | Biological enzyme accuse temperature reaction unit |
-
2019
- 2019-01-21 CN CN201920094373.8U patent/CN209797972U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111621421A (en) * | 2020-06-16 | 2020-09-04 | 浙江省肿瘤医院 | Tumor cell culture device |
| CN111621421B (en) * | 2020-06-16 | 2023-08-15 | 浙江省肿瘤医院 | Tumor cell culture device |
| CN112608840A (en) * | 2020-12-16 | 2021-04-06 | 李娄 | Novel adjustable cell culture dish frame |
| CN112608840B (en) * | 2020-12-16 | 2023-08-25 | 上海倍锦生物科技有限公司 | Novel adjustable cell culture dish frame |
| CN113018568A (en) * | 2021-02-28 | 2021-06-25 | 南京帝基生物科技有限公司 | Cell back transfusion device for cell biotherapy |
| CN113150990A (en) * | 2021-05-15 | 2021-07-23 | 黄韶平 | Cell culture dish |
| CN118580952A (en) * | 2024-07-24 | 2024-09-03 | 江苏奕农生物股份有限公司 | Biological enzyme accuse temperature reaction unit |
| CN118530839A (en) * | 2024-07-26 | 2024-08-23 | 中科南京生命健康高等研究院 | Cell culture reactor |
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Legal Events
| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191217 Termination date: 20220121 |