CN112964525A - Blood extractor for bile duct cancer treatment and detection - Google Patents
Blood extractor for bile duct cancer treatment and detection Download PDFInfo
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- CN112964525A CN112964525A CN202110161680.5A CN202110161680A CN112964525A CN 112964525 A CN112964525 A CN 112964525A CN 202110161680 A CN202110161680 A CN 202110161680A CN 112964525 A CN112964525 A CN 112964525A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/32—Polishing; Etching
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
Abstract
The invention discloses a blood extractor for treating and detecting cholangiocarcinoma, which comprises a mounting shell, a stable connection frame, a mounting seat, a rotating seat, a centrifugal radius adjusting assembly, a temporary storage bin and a blood test tube clamping mechanism, wherein the periphery of the mounting seat is fixed in the mounting shell by the stable connection frame; the top of rotating the seat is fixed with centrifugal radius adjusting part, centrifugal radius adjusting part includes two at least regulation ends, and two regulation end respectively are fixed with a temporary storage storehouse, the last fixed intercommunication of temporary storage storehouse has the mounting disc, a plurality of blood test tube fixture are installed to the circumference array on the mounting disc, blood test tube fixture is used for the centre gripping blood test tube of selectivity, and each centrifugal radius adjusting part's regulation end is independent control to change the degree that blood centrifugation was drawed in the different blood test tubes.
Description
Technical Field
The invention relates to the technical field of blood extraction, in particular to a blood extractor for treating and detecting bile duct cancer.
Background
Cholangiocarcinoma is a primary hepatobiliary tumor, the incidence and recurrence rate of which are high, and in recent years, the overall incidence rate of cholangiocarcinoma gradually increases, when the cholangiocarcinoma of a patient is treated and detected, blood of the patient needs to be extracted and assayed, the current common blood extractor is a centrifugal blood extractor which separates plasma and blood cells with different densities by centrifugal force to achieve the purpose of separation and purification, and further to extract the cells of the blood, but the centrifugal blood extractor has common extraction efficiency and effect on the blood, the centrifugal force is usually realized by rotating speed, the adjustment is unified adjustment, and the centrifugal force applied to different test tubes cannot be independently changed.
Therefore, it is necessary to provide a blood extractor for bile duct cancer treatment and detection to solve the problems of the background art.
Disclosure of Invention
In order to achieve the purpose, the invention provides the following technical scheme: a blood extractor for treating and detecting cholangiocarcinoma comprises a mounting shell, a stable connection frame, a mounting seat, a rotating seat, a centrifugal radius adjusting assembly, a temporary storage bin and a blood test tube clamping mechanism, wherein the periphery of the mounting seat is fixed in the mounting shell by the stable connection frame, the rotating seat is rotatably arranged on the mounting seat, and the rotating action of the rotating seat is controlled by a rotation driving assembly;
the top of rotating the seat is fixed with centrifugal radius adjusting part, centrifugal radius adjusting part includes two at least regulation ends, and two regulation end respectively are fixed with a temporary storage storehouse, the last fixed intercommunication of temporary storage storehouse has the mounting disc, a plurality of blood test tube fixture are installed to the circumference array on the mounting disc, blood test tube fixture is used for the centre gripping blood test tube of selectivity, and each centrifugal radius adjusting part's regulation end is independent control to change the degree that blood centrifugation was drawed in the different blood test tubes.
Further, as preferred, centrifugal radius adjustment assembly includes installation storehouse, telescopic link and piston rod, and is wherein, a plurality of the telescopic link is the inside that the circumference array was arranged and was fixed in the installation storehouse, the output of telescopic link is fixed with the piston rod, the piston rod slides and stretches out the installation storehouse, just the end that stretches out of piston rod is as centrifugal radius adjustment assembly's regulation end and temporary storage storehouse fixed continuous.
Further, as preferred, the installation bin has seted up the through-hole with piston rod contact position department to the slide adjustment of piston rod, and the through-hole embeds there is the electromagnetism magnetic ring, the electromagnetism magnetic ring can provide the damping for the slip of piston rod, and the size of this damping is controlled by the magnetism size of electromagnetism magnetic ring.
Further, as preferred, but the inside relative slip's of temporary storage storehouse is connected with supplies liquid and divides the pipe, supply liquid to divide and seal between pipe and the temporary storage storehouse and link to each other, just supply liquid to divide the pipe to fixedly pass the installation storehouse and supply liquid storehouse to link to each other, supply the liquid storehouse to open in the inside of rotating the seat, and pass through the liquid that supplies the liquid storehouse to provide can get into in proper order and get into to temporary storage storehouse, mounting disc and blood test tube fixture.
Further, as preferred, blood test tube fixture includes test tube centre gripping shell, centre gripping bag and solenoid valve, the fixed embedding of centre gripping shell is in the mounting disc, the fixed groove form centre gripping bag that has laid of inner wall of centre gripping shell, the bottom of centre gripping bag is provided with the opening for be linked together with the mounting disc, and the opening part is provided with the solenoid valve.
Further, it is preferable that the holding bag has an elastic expansion limit, and when the liquid inside the holding bag is filled up to the elastic expansion limit and cannot be expanded any more, the amount of the liquid inside the holding bag reaches two thirds of the amount of the blood tube capable of holding the blood, and when the blood tube is not placed in the blood tube holding mechanism, the holding bag is filled with the liquid so as to balance the mass.
Further, preferably, an oscillator is fixed in the temporary storage bin, and an oscillation end of the oscillator extends into the mounting disc.
Further, preferably, the oscillators are linear oscillators having an oscillation law, each of the oscillators is independently controlled, and an oscillation frequency and an amplitude of each of the oscillators are adjustable.
Further, as preferred, the rotation drive assembly includes gear storehouse, driving gear and motor, wherein, the fixed embedding in one side at the mount pad in gear storehouse, the rotation is provided with the driving gear in the gear storehouse, the driving gear is driven by the motor of fixing in gear storehouse below, the driving gear meshes with driven gear mutually, the fixed cover of driven gear is established in the outside of rotating the seat.
Further, as preferred, the confession liquid storehouse is supplied liquid by the confession liquid subassembly, the confession liquid subassembly includes pump, feed tank, total feed pipe and body fixing base, wherein, total feed pipe links to each other with the sealed rotation in confession liquid storehouse, just the total feed pipe adopts the body fixing base to fix in the mount pad, the one end that the feed tank was kept away from to total feed pipe adopts pump and feed tank to be linked together.
Compared with the prior art, the invention provides a blood extractor for treating and detecting bile duct cancer, which has the following beneficial effects:
1. in the invention, the adjusting ends of the centrifugal radius adjusting components can adjust the position of the mounting disc, so that the centrifugal extraction degree of blood in different blood test tubes is changed, and plasma and blood cells with different densities are separated by virtue of the centrifugal force generated when the rotating seat rotates, so that the purpose of separation and purification is achieved, the cell extraction of the blood is further realized, and the subsequent treatment and detection of cholangiocarcinoma are facilitated;
2. according to the invention, the clamping bag can be used for providing stable clamping for the blood test tube, and the blood test tube can be clamped in a flexible clamping manner due to the fact that liquid is filled in the clamping bag, so that the possibility that the blood test tube is damaged is reduced;
3. the blood test tube clamping mechanisms are arranged, so that blood in the blood test tubes can be synchronously centrifuged and extracted, and when no blood test tube is placed in the blood test tube clamping mechanisms, liquid can be supplemented by utilizing elastic expansion of the clamping bags, so that the clamping bags are filled with liquid, the quality is balanced, and the centrifugation stability is improved.
4. In the invention, the oscillator is fixed in the temporary storage bin, the oscillation end of the oscillator extends into the mounting disc, and the oscillator can oscillate the liquid in the mounting disc, so that the blood in the blood test tube is oscillated and mixed in a hydraulic oscillation mode, and the centrifugal effect is improved.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a partially enlarged schematic view of FIG. 1;
FIG. 3 is a schematic structural view of a blood test tube holding mechanism according to the present invention;
in the figure: 1. mounting a shell; 2. a stable connection frame; 3. a mounting seat; 4. a rotating seat; 5. a rotation drive assembly; 6. a centrifugal radius adjustment assembly; 7. a temporary storage bin; 8. mounting a disc; 9. a blood test tube clamping mechanism; 10. a blood test tube; 11. a temperature controller; 12. opening and closing the door; 13. a stabilizing block; 14. a pump; 15. a liquid supply tank; 16. a liquid supply bin; 17. liquid supply branch pipes; 18. a total feed tube; 19. a pipe body fixing seat; 20. an oscillator; 51. a gear chamber; 52. a driving gear; 53. a motor; 61. installing a bin; 62. a telescopic rod; 63. a piston rod; 64. an electromagnet ring; 91. the test tube clamps the outer cover; 92. a clamping bladder; 93. an electromagnetic valve.
Detailed Description
Referring to fig. 1 to 3, in an embodiment of the present invention, a blood extractor for treating and detecting cholangiocarcinoma includes an installation shell 1, a stable connection frame 2, an installation base 3, a rotation base 4, a centrifugal radius adjusting assembly 6, a temporary storage bin 7, and a blood test tube clamping mechanism 9, wherein the periphery of the installation base 3 is fixed inside the installation shell 1 by using the stable connection frame 2, the installation base 3 is rotatably provided with the rotation base 4, and a rotation action of the rotation base 4 is controlled by a rotation driving assembly 5;
a centrifugal radius adjusting component 6 is fixed above the rotating seat 4, the centrifugal radius adjusting component 6 at least comprises two adjusting ends, a temporary storage bin 7 is fixed on each adjusting end, a mounting disc 8 is fixedly communicated with the temporary storage bin 7, a plurality of blood test tube clamping mechanisms 9 are arranged on the mounting disc 8 in a circumferential array mode, the blood test tube clamping mechanisms 9 are used for selectively clamping blood test tubes 10, the adjusting ends of the centrifugal radius adjusting components 6 are independently adjusted, the centrifugal extraction degree of blood in different blood test tubes 10 is changed, and plasma and blood cells with different densities are separated by means of centrifugal force generated when the rotating seat rotates, so that the purposes of separation and purification are achieved, cell extraction of blood is achieved, and subsequent treatment and detection of cholangiocarcinoma are facilitated.
In this embodiment, as shown in fig. 2, the centrifugal radius adjusting assembly 6 includes an installation bin 61, a plurality of telescopic rods 62 arranged in a circumferential array and fixed inside the installation bin 61, the output end of each telescopic rod 62 is fixed with a piston rod 63, the piston rod 63 slides and extends out of the installation bin 61, the extending end of the piston rod 63 is fixedly connected with the temporary storage bin 7 as the adjusting end of the centrifugal radius adjusting assembly 6, and the telescopic rods 62 can be selected from miniature electric telescopic rods.
In a preferred embodiment, a through hole is formed at a contact position of the mounting bin 61 and the piston rod 63, so that the piston rod 63 can slide and adjust, an electromagnet ring 64 is embedded in the through hole, the electromagnet ring 64 can provide damping for the sliding of the piston rod 63, and the damping is controlled by the magnetic strength of the electromagnet ring.
In addition, the temporary storage bin 7 is connected with a liquid supply branch pipe 17 in a relatively sliding manner, the liquid supply branch pipe 17 is connected with the temporary storage bin 7 in a sealing manner, the liquid supply branch pipe 17 fixedly penetrates through the installation bin 61 to be connected with the liquid supply bin 16, the liquid supply bin 16 is arranged in the rotating seat 4, and liquid provided by the liquid supply bin 16 can enter the temporary storage bin 7, the installation disc 8 and the blood test tube clamping mechanism 9 in sequence.
In this embodiment, as shown in fig. 3, the blood test tube clamping mechanism 9 includes a test tube clamping housing 91, a clamping bag 92 and an electromagnetic valve 93, the clamping housing 91 is fixedly embedded in the mounting plate 8, the inner wall of the clamping housing 91 is fixedly provided with a groove-shaped clamping bag 92, the bottom of the clamping bag 92 is provided with an opening for communicating with the mounting plate 8, and the opening is provided with the electromagnetic valve 93.
Further, the holding bag 92 has an elastic expansion limit, and when the liquid inside the holding bag 92 is filled up to the elastic expansion limit and cannot be expanded any more, the amount of the liquid inside the holding bag 92 reaches two thirds of the amount of the blood tube 10 capable of holding the blood, and when the blood tube 10 is not placed in the blood tube holding mechanism 9, the holding bag 92 is filled with the liquid so as to balance the mass, it should be further explained that, in the present invention, the holding bag 92 can be used to provide a stable holding for the blood tube 10, and since the liquid is filled in the holding bag 92, it can hold the blood tube in a flexible holding manner, reducing the possibility that the blood tube is damaged, and in addition, the present invention provides a plurality of blood tube holding mechanisms 9 capable of performing centrifugal extraction of the blood in a plurality of blood tubes 10 simultaneously, and, when the blood tube 10 is not placed in the blood tube holding mechanism 9, by utilizing the elastic expansion of the clamping bag, liquid can be supplemented, so that the clamping bag 92 is filled with liquid, the quality is balanced, and the centrifugal stability is improved.
In a preferred embodiment, an oscillator 20 is fixed in the temporary storage bin 7, an oscillation end of the oscillator 20 extends into the mounting plate 8, and the liquid in the mounting plate 8 can be oscillated by the oscillator, so that the blood in the blood test tube 10 is oscillated and mixed in a hydraulic oscillation mode, and the centrifugal effect is improved.
In a preferred embodiment, the oscillators 20 are linear oscillators having an oscillation law, each of the oscillators 20 is independently controlled, and an oscillation frequency and an amplitude of each of the oscillators 20 are adjustable.
In this embodiment, the rotation driving assembly 5 includes a gear bin 51, a driving gear 52 and a motor 53, wherein the gear bin 51 is fixedly embedded in one side of the mounting base 3, the driving gear 52 is rotatably disposed in the gear bin 51, the driving gear 52 is driven by the motor 53 fixed below the gear bin 51, the driving gear 52 is engaged with a driven gear, and the driven gear is fixedly sleeved outside the rotation base 4.
In this embodiment, the liquid supply bin 16 is supplied with liquid by a liquid supply assembly, the liquid supply assembly includes a pumping pump 14, a liquid supply tank 15, a main liquid supply pipe 18 and a pipe fixing seat 19, wherein the main liquid supply pipe 18 is connected with the liquid supply bin 16 in a sealing and rotating manner, the main liquid supply pipe 18 is fixed in the mounting seat 3 by the pipe fixing seat 19, and one end of the main liquid supply pipe 18, which is far away from the liquid supply bin 16, is communicated with the liquid supply tank 15 by the pumping pump 14.
When concrete implementation, put into blood test tube fixture 9 with a plurality of blood test tubes 10 that are equipped with blood, then adjust the end through the independent flexible regulation of centrifugation radius adjustment subassembly 6, thereby change the degree that the blood centrifugation was drawed in the follow-up different blood test tubes 10, then, supply liquid for each temporary storage bin 7 through supplying liquid storehouse 16, make centre gripping bag centre gripping blood test tube 10 or centre gripping bag inflation keep balance, at last with the help of the centrifugal force that produces when rotating the seat and rotating, the plasma and the blood cell of the different density size of feasible separate, reach the purpose of separation purification, and then the realization can to the cell extraction of blood.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention are equivalent to or changed within the technical scope of the present invention.
Claims (10)
1. A blood extractor for treating and detecting cholangiocarcinoma comprises a mounting shell (1), a stable connection frame (2), a mounting seat (3), a rotating seat (4), a centrifugal radius adjusting assembly (6), a temporary storage bin (7) and a blood test tube clamping mechanism (9), wherein the periphery of the mounting seat (3) is fixed inside the mounting shell (1) by the stable connection frame (2), the rotating seat (4) is rotatably arranged on the mounting seat (3), and the rotating action of the rotating seat (4) is controlled by a rotation driving assembly (5);
the method is characterized in that: the top of rotating seat (4) is fixed with centrifugal radius adjusting part (6), centrifugal radius adjusting part (6) include two at least regulation ends, and two regulation are served and respectively are fixed with one and keep in storehouse (7) temporarily, it has mounting disc (8) to keep in storehouse (7) last fixed intercommunication temporarily, a plurality of blood test tube fixture (9) are installed to circumference array on mounting disc (8), blood test tube fixture (9) are used for selective centre gripping blood test tube (10), and each the regulation end of centrifugal radius adjusting part (6) is independent control to change the degree that the blood centrifugation was drawed in different blood test tubes (10).
2. The blood extractor for bile duct cancer treatment and detection according to claim 1, wherein: centrifugal radius adjusting part (6) are including installation storehouse (61), telescopic link (62) and piston rod (63), wherein, a plurality of telescopic link (62) are the inside that the circumference array was arranged and was fixed in installation storehouse (61), the output of telescopic link (62) is fixed with piston rod (63), piston rod (63) slide and stretch out installation storehouse (61), just the end that stretches out of piston rod (63) is fixed continuous with temporary storage storehouse (7) as the regulation end of centrifugal radius adjusting part (6).
3. The blood extractor for bile duct cancer treatment and detection according to claim 2, wherein: the through hole is formed in the contact position of the installation bin (61) and the piston rod (63), so that the piston rod (63) can slide and adjust, an electromagnet ring (64) is embedded into the through hole, the electromagnet ring (64) can provide damping for the sliding of the piston rod (63), and the damping is controlled by the magnetism of the electromagnet ring.
4. The blood extractor for bile duct cancer treatment and detection according to claim 2, wherein: but the inside relative slip's of temporary storage storehouse (7) is connected with and supplies liquid to divide pipe (17), supply liquid to divide between pipe (17) and the temporary storage storehouse (7) sealed linking to each other, just supply liquid to divide pipe (17) fixed pass installation storehouse (61) and supply liquid storehouse (16) to link to each other, supply liquid storehouse (16) to set up in the inside of rotating seat (4), and pass through the liquid that supplies liquid storehouse (16) to provide can get into in proper order and enter into to temporary storage storehouse (7), mounting disc (8) and blood test tube fixture (9).
5. The blood extractor for bile duct cancer treatment and detection according to claim 4, wherein: blood test tube fixture (9) include test tube centre gripping shell (91), centre gripping bag (92) and solenoid valve (93), the fixed embedding of centre gripping shell (91) is in mounting disc (8), the fixed groove form centre gripping bag (92) of having laid of inner wall of centre gripping shell (91), the bottom of centre gripping bag (92) is provided with the opening for be linked together with mounting disc (8), and the opening part is provided with solenoid valve (93).
6. The blood extractor for bile duct cancer treatment and detection according to claim 4, wherein: the clamping bag (92) has elastic expansion limit, when the liquid in the clamping bag (92) is full of the liquid reaching the elastic expansion limit and can not expand any more, the amount of the liquid in the clamping bag (92) reaches two thirds of the amount of the blood contained in the blood test tube (10), and when the blood test tube (10) is not placed in the blood test tube clamping mechanism (9), the clamping bag (92) is full of the liquid so as to balance the mass.
7. The blood extractor for bile duct cancer treatment and detection according to claim 1, wherein: an oscillator (20) is fixed in the temporary storage bin (7), and an oscillation end of the oscillator (20) extends into the mounting disc (8).
8. The blood extractor for bile duct cancer treatment and detection according to claim 7, wherein: the oscillator (20) is a linear oscillator with an oscillation rule, each oscillator (20) is independently controlled, and the oscillation frequency and the amplitude of each oscillator (20) are adjustable.
9. The blood extractor for bile duct cancer treatment and detection according to claim 1, wherein: rotate drive assembly (5) and include gear storehouse (51), driving gear (52) and motor (53), wherein, gear storehouse (51) is fixed to be embedded in one side of mount pad (3), it is provided with driving gear (52) to rotate in gear storehouse (51), driving gear (52) are driven by motor (53) of fixing in gear storehouse (51) below, driving gear (52) mesh with driven gear mutually, the fixed cover of driven gear is established in the outside of rotating seat (4).
10. The blood extractor for bile duct cancer treatment and detection according to claim 4, wherein: the feed liquor storehouse (16) supplies liquid by the feed liquor subassembly, the feed liquor subassembly includes pump (14), feed liquor groove (15), total feed pipe (18) and body fixing base (19), wherein, total feed pipe (18) and feed liquor storehouse (16) are sealed to rotate and are linked to each other, just total feed pipe (18) adopt body fixing base (19) to fix in mount pad (3), the one end that feed liquor storehouse (16) were kept away from to total feed pipe (18) adopts pump (14) to be linked together with feed liquor groove (15).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110161680.5A CN112964525B (en) | 2021-02-05 | 2021-02-05 | Blood extractor for bile duct cancer treatment and detection |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110161680.5A CN112964525B (en) | 2021-02-05 | 2021-02-05 | Blood extractor for bile duct cancer treatment and detection |
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| CN112964525B CN112964525B (en) | 2022-04-01 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113786934A (en) * | 2021-09-17 | 2021-12-14 | 郑州大学第一附属医院 | Kit for extracting total RNA from blood and use method thereof |
| CN114717098A (en) * | 2022-03-07 | 2022-07-08 | 山东尔雅基因科技有限公司 | Blood sample preparation and storage device for rapidly extracting DNA |
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Application publication date: 20210615 Assignee: Hunan tiangenle Weijun Technology Co.,Ltd. Assignor: HUNAN NORMAL University Contract record no.: X2022980028939 Denomination of invention: A blood extractor for treatment and detection of cholangiocarcinoma Granted publication date: 20220401 License type: Common License Record date: 20221228 |
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