CN112932986A - Blueberry anthocyanin base composition with lip wrinkle fading effect, lipstick and preparation method thereof - Google Patents
Blueberry anthocyanin base composition with lip wrinkle fading effect, lipstick and preparation method thereof Download PDFInfo
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- CN112932986A CN112932986A CN202110418731.8A CN202110418731A CN112932986A CN 112932986 A CN112932986 A CN 112932986A CN 202110418731 A CN202110418731 A CN 202110418731A CN 112932986 A CN112932986 A CN 112932986A
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- blueberry anthocyanin
- blueberry
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- extract
- freeze
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
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Abstract
The invention relates to a blueberry anthocyanin base composition with a lip wrinkle fading effect, a lipstick and a preparation method thereof, wherein the blueberry anthocyanin base composition comprises the following components in parts by weight: blueberry anthocyanin freeze-dried powder, kapok extract and oriental cherry extract. According to the invention, the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract are creatively combined to be used as the basic composition of the lip-wrinkle-fading efficacy product, the three components are mutually matched, and the composition has unexpected synergistic effect in the aspects of removing free radicals, inhibiting collagenase and inhibiting elastase, has a very obvious lip-wrinkle-fading efficacy, is safe and non-irritant, and has good use feeling.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a blueberry anthocyanin base composition, a lipstick and a preparation method thereof, and in particular relates to a blueberry anthocyanin base composition with a lip wrinkle fading effect, a lipstick and a preparation method thereof.
Background
The lip skin, which is the weakest part of the facial skin, is located at the edge of the mouth, and has a large distribution of capillaries, and hemoglobin is activated, thereby showing a red color. The lip skin structure is different from the skin structure of other parts of the face, pores and sebaceous glands are not formed, sweat or sebum cannot be secreted, the stratum corneum of the lip skin is thin and has extremely fast metabolism, the content of natural moisturizing factors and water molecules is low, and the water loss speed is very fast. Meanwhile, lips are exposed to ultraviolet rays frequently, and the structure of the lips does not contain melanin, so that the lips cannot resist the ultraviolet rays, the skin of the lips often contacts with pollutant particles in the atmosphere, in addition, the lips are not protected better by consumers than the skin of other parts of the face, and the makeup removal of the lip makeup by partial makeup consumers is not in place, so that the lip skin has very weak defense capability to various external stimulation factors, and is easy to damage, thereby causing the lips to crack and peel, and the lip lines to deepen.
The common effective components for fading lip wrinkles comprise retinol and derivatives thereof, vitamin C and derivatives thereof, polypeptide derivatives and the like. Wherein, the retinol is easy to be oxidized, and the activity of the derivative of the retinol is not as good as that of the retinol to play an excellent effect of fading skin lines; vitamin C and derivatives thereof have active molecules and poor stability, are easy to oxidize and lose activity, and weaken the lip wrinkle fading effect; polypeptides and derivatives thereof are various in types and high in permeability, can stimulate collagen synthesis in skin, and have water-soluble types and oil-soluble types, and the oil-soluble types are conveniently added into an oil-based system, but the addition of the water-soluble types often needs a large amount of surfactants such as stearic acid and other fatty acids, sorbitan fatty acid esters and other surfactants to stabilize the existence of the surfactants, and the surfactants can increase the sensitivity of lips and have the potential risk of stimulating skin tissues.
CN104688605A discloses a lip balm for lip wrinkle fading, which is composed of the following raw materials in parts by weight: 10-20 parts of sheep oil, 5-15 parts of beeswax, 7-9 parts of castor seed oil, 3-5 parts of liquid paraffin, 1-3 parts of polybutene, 3-5 parts of tocopherol acetate, 0.2-0.4 part of silica, 0.3-0.5 part of vitamin E, 10-14 parts of shea butter, 3-5 parts of almond oil and 2-4 parts of natural perfume. The lipstick product is also limited in its effectiveness in lightening the lips.
CN105326753A discloses a nourishing lipstick for lip wrinkle fading and a preparation method thereof, wherein the lipstick is prepared from the following raw materials: shark liver oil, jojoba oil, lecithin, olive oil, peach blossom, carrot, mushroom, avocado, carmine radish, beeswax, royal jelly, jasmine essential oil, chamomile essential oil, and Chinese medicinal additive; the traditional Chinese medicine additive is prepared from the following raw material medicines: cortex Cinnamomi, fructus Akebiae, herba Senecionis Scandentis, Notoginseng radix, radix Acanthopanacis Senticosi, herba Gynostemmatis, radix Rhodiolae, radix astragali, radix Arnebiae, herba Rosmarini officinalis, radix Hamamelis mollis, and herba Epimedii. The lipstick product has obvious effect on carbonized lip wrinkles, but has complex components, complex preparation process and higher cost.
Therefore, it would be of great interest to develop a lipstick product that has a relatively simple composition, but has a very pronounced lip gloss effect.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a blueberry anthocyanin base composition, a lipstick and a preparation method thereof, and particularly provides a blueberry anthocyanin base composition with a lip wrinkle fading effect, a lipstick and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a blueberry anthocyanin base composition with a lip line fading effect, which comprises the following components in part by weight: blueberry anthocyanin freeze-dried powder, kapok extract and oriental cherry extract.
According to the invention, the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract are creatively combined to be used as the basic composition of the lip-wrinkle-fading efficacy product, the three components are mutually matched, and the composition has unexpected synergistic effect in the aspects of removing free radicals, inhibiting collagenase and inhibiting elastase, has a very obvious lip-wrinkle-fading efficacy, is safe and non-irritant, and has good use feeling.
Preferably, the blueberry anthocyanin base composition comprises the following components in parts by weight: 1-2 parts of blueberry anthocyanin freeze-dried powder, 0.5-1 part of kapok extract and 0.5-1 part of oriental cherry extract.
The blueberry anthocyanin freeze-dried powder can be 1 part, 1.1 part, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts and the like.
The weight portion of the common bombax flower extract can be 0.5 portion, 0.6 portion, 0.7 portion, 0.8 portion, 0.9 portion, 1 portion and the like.
The cherry blossom extract can be 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like in parts by weight.
When the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract are combined in the specific weight ratio, the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract have more remarkable synergistic effect in the aspects of removing free radicals, inhibiting collagenase and inhibiting elastase, and have more remarkable lip wrinkle fading effect.
In the invention, the blueberry anthocyanin freeze-dried powder can be a product purchased from a commercial way or obtained by self-making.
As a preferred technical scheme, the blueberry anthocyanin freeze-dried powder can be prepared by a preparation method comprising the following steps:
(S1) homogenizing blueberries and sieving to obtain blueberry pulp;
(S2) freeze-drying the blueberry pulp into blueberry powder;
(S3) performing microwave extraction by taking an ethanol water solution as an extraction solvent to obtain a blueberry anthocyanin extracting solution;
(S4) carrying out condensation rotary evaporation on the blueberry anthocyanin extracting solution to remove the solvent, and then carrying out freeze drying to obtain the blueberry anthocyanin freeze-dried powder.
Preferably, the number of the sieved meshes in the step (S1) is 100-140 meshes, such as 100 meshes, 105 meshes, 110 meshes, 115 meshes, 120 meshes, 125 meshes, 130 meshes, 135 meshes, 140 meshes, and the like, and other specific point values in the value range can be selected, which is not described herein again.
Preferably, the concentration of the ethanol aqueous solution in the step (S3) is 40-60%, for example, 40%, 42%, 45%, 47%, 50%, 52%, 55%, 58%, 60%, etc., and other specific values within the numerical range can be selected, which is not described herein again. Preferably 45-55%.
Preferably, the liquid-solid ratio of the ethanol aqueous solution to the blueberry powder in the step (S3) is 10-20mL/g, for example, 10mL/g, 12mL/g, 15mL/g, 18mL/g, 20mL/g, and the like, and other specific points in the value range can be selected, which is not described herein again.
Preferably, the power of the microwave extraction in the step (S3) is 400-600W, such as 400W, 420W, 450W, 480W, 500W, 520W, 550W, 580W, 600W, etc.; the time is 10-20min, for example, 10min, 12min, 15min, 18min, 20min, etc., and other specific point values within the above numerical range can be selected, which is not described herein again.
The specific method of the blueberry anthocyanin freeze-dried powder adopts an ethanol microwave extraction method, and the prepared blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract have better matching effect on lip line fading effect by controlling the concentration of ethanol, the liquid-solid ratio of an ethanol water solution to blueberry powder and the power and time of microwave extraction.
In a second aspect, the invention provides a blueberry anthocyanin lipstick with a lip wrinkle fading effect, which is prepared from the following raw materials: a blueberry anthocyanidin base composition as described in the first aspect, vegetable fat and oil, aloe vera gel juice, vitamin C, honey extract and beeswax.
The vegetable oil and the honey extract mainly have the functions of moistening and moisturizing; the aloe gel juice and the vitamin C mainly play a role in resisting oxidation; beeswax acts to aid in the formation of lipstick.
The blueberry anthocyanin lipstick provided by the invention is relatively simple in components, and can obtain a good lip wrinkle fading effect under the condition of relatively low cost.
Preferably, the blueberry anthocyanin lipstick comprises the following preparation raw materials in parts by weight: 1-2 parts of blueberry anthocyanin freeze-dried powder, 0.5-1 part of common bombax flower extract, 0.5-1 part of cherry blossom extract, 15-20 parts of avocado oil, 10-15 parts of aloe gel juice, 10-15 parts of vitamin C, 10-15 parts of honey extract and 50-70 parts of beeswax.
The avocado oil can be 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts and the like.
The aloe gel juice can be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts and the like in parts by weight.
The weight parts of the vitamin C can be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts and the like.
The honey extract can be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts and the like.
The beeswax is 50 parts, 53 parts, 55 parts, 58 parts, 60 parts, 62 parts, 64 parts, 65 parts, 67 parts, 68 parts, 70 parts and the like.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the vegetable oil is avocado oil.
Avocado oil is preferred as vegetable oil because avocado oil maintains the elasticity of the skin of the lips, makes the lips soft and smooth, and at the same time resists the damage of external ultraviolet rays, and can further promote the effect of lipstick on lip wrinkle lightening.
Preferably, the blueberry anthocyanin lipstick further comprises natural perfume.
In a third aspect, the invention provides a preparation method of the blueberry anthocyanin lipstick with the lip line fading effect as described in the second aspect, and the preparation method comprises the following steps:
(1) mixing the blueberry anthocyanin freeze-dried powder with vegetable oil, heating and stirring;
(2) mixing beeswax with the product of the step (1), heating and stirring;
(3) mixing the product obtained in step (2) with kapok extract, oriental cherry extract, aloe gel juice, vitamin C and honey extract, stirring, and pouring.
Preferably, the heating in step (1) refers to heating to 55-65 ℃, for example, 55 ℃, 58 ℃, 60 ℃, 63 ℃, 65 ℃ and the like, and other specific values in the numerical range can be selected, and are not described in detail herein.
Preferably, the heating in step (2) refers to heating to 75-85 ℃, such as 75 ℃, 78 ℃, 80 ℃, 82 ℃, 85 ℃ and the like, and other specific values in the numerical range can be selected, and are not described in detail herein.
Preferably, the stirring in step (3) is performed at 15-40 ℃, for example, 15 ℃, 20 ℃, 25 ℃, 30 ℃, 35 ℃, 40 ℃ and the like, and other specific values in the value range can be selected, which is not described in detail herein.
The preparation method of the blueberry anthocyanin lipstick is simple and easy to operate, is very suitable for industrial scale production,
compared with the prior art, the invention has the following beneficial effects:
according to the invention, the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract are creatively combined to be used as the basic composition of the lip-wrinkle-fading efficacy product, the three components are mutually matched, and the composition has unexpected synergistic effect in the aspects of removing free radicals, inhibiting collagenase and inhibiting elastase, has a very obvious lip-wrinkle-fading efficacy, is safe and non-irritant, and has good use feeling. The blueberry anthocyanin lipstick containing the blueberry anthocyanin is relatively simple in component, can obtain a good lip wrinkle fading effect under the condition of low cost, and is good in use feeling.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The kapok extract referred to in the following examples was purchased from holo-au wood under model No. SH20201112, and the oriental cherry extract was purchased from soyol under model No. SA-SSA 118.
Preparation example 1
The preparation example provides blueberry anthocyanin freeze-dried powder, and the preparation method comprises the following steps:
(S1) homogenizing blueberries, and sieving the homogenate with a 120-mesh sieve to obtain blueberry pulp;
(S2) freeze-drying the blueberry pulp into blueberry powder;
(S3) performing microwave extraction with 50% ethanol water solution with the liquid-solid ratio of 15mL/g to blueberry powder as an extraction solvent, wherein the power of the microwave extraction is 550W, and the time is 15min to obtain blueberry anthocyanin extracting solution;
(S4) carrying out condensation rotary evaporation on the blueberry anthocyanin extracting solution to remove the solvent, and then carrying out freeze drying to obtain the blueberry anthocyanin freeze-dried powder.
Preparation example 2
The preparation example provides blueberry anthocyanin freeze-dried powder, and the preparation method comprises the following steps:
(S1) homogenizing blueberries, and sieving the homogenate with a 100-mesh sieve to obtain blueberry pulp;
(S2) freeze-drying the blueberry pulp into blueberry powder;
(S3) performing microwave extraction with 45% ethanol aqueous solution with the liquid-solid ratio of 20mL/g to blueberry powder as an extraction solvent, wherein the microwave extraction power is 600W, and the time is 10min to obtain blueberry anthocyanin extracting solution;
(S4) carrying out condensation rotary evaporation on the blueberry anthocyanin extracting solution to remove the solvent, and then carrying out freeze drying to obtain the blueberry anthocyanin freeze-dried powder.
Preparation example 3
The preparation example provides blueberry anthocyanin freeze-dried powder, and the preparation method comprises the following steps:
(S1) homogenizing blueberries, and sieving the homogenate with a 140-mesh sieve to obtain blueberry pulp;
(S2) freeze-drying the blueberry pulp into blueberry powder;
(S3) performing microwave extraction with 55% ethanol aqueous solution with the liquid-solid ratio of 10mL/g to blueberry powder as an extraction solvent, wherein the microwave extraction power is 400W, and the time is 20min to obtain blueberry anthocyanin extracting solution;
(S4) carrying out condensation rotary evaporation on the blueberry anthocyanin extracting solution to remove the solvent, and then carrying out freeze drying to obtain the blueberry anthocyanin freeze-dried powder.
Preparation example 4
The preparation example provides blueberry anthocyanin freeze-dried powder, and the preparation method of the blueberry anthocyanin freeze-dried powder is only different from the preparation example 1 in that: the concentration of the ethanol aqueous solution was 65%, and the other conditions were kept constant.
Preparation example 5
The preparation example provides blueberry anthocyanin freeze-dried powder, and the preparation method of the blueberry anthocyanin freeze-dried powder is only different from the preparation example 1 in that: the concentration of the ethanol aqueous solution was 35%, and the other conditions were kept constant.
Preparation example 6
The preparation example provides blueberry anthocyanin freeze-dried powder, and the preparation method of the blueberry anthocyanin freeze-dried powder is only different from the preparation example 1 in that: and (3) performing ultrasonic extraction by using 50% ethanol water solution with a liquid-solid ratio of 15mL/g to blueberry powder as an extraction solvent, wherein the microwave extraction power is 550W, and the microwave extraction time is 15min to obtain the blueberry anthocyanin extracting solution.
Example 1
The embodiment provides a basic composition, which is prepared by uniformly mixing and stirring 2 parts of blueberry anthocyanin freeze-dried powder prepared in preparation example 1,1 part of common bombax flower extract and 1 part of oriental cherry flower extract.
Example 2
The embodiment provides a basic composition, which is prepared by uniformly mixing and stirring 2 parts of blueberry anthocyanin freeze-dried powder prepared in preparation example 2, 0.5 part of common bombax flower extract and 1 part of oriental cherry flower extract.
Example 3
The embodiment provides a basic composition, which is prepared by uniformly mixing and stirring 2 parts of blueberry anthocyanin freeze-dried powder prepared in preparation example 3, 1 part of common bombax flower extract and 0.5 part of oriental cherry flower extract.
Example 4
The embodiment provides a basic composition, which is prepared by uniformly mixing and stirring 2 parts of blueberry anthocyanin freeze-dried powder prepared in preparation example 4, 1 part of common bombax flower extract and 1 part of oriental cherry flower extract.
Example 5
The embodiment provides a basic composition, which is prepared by uniformly mixing and stirring 2 parts of blueberry anthocyanin freeze-dried powder prepared in preparation example 5, 1 part of common bombax flower extract and 1 part of oriental cherry flower extract.
Example 6
The embodiment provides a basic composition, which is prepared by uniformly mixing and stirring 2 parts of blueberry anthocyanin freeze-dried powder prepared in preparation example 6, 1 part of common bombax flower extract and 1 part of oriental cherry flower extract.
Comparative example 1
This example provides a pure lyophilized powder of blueberry anthocyanidin from preparation example 1.
Comparative example 2
This example provides a pure kapok extract.
Comparative example 3
This example provides a simple cherry blossom extract.
Comparative example 4
The composition is prepared by uniformly mixing and stirring the blueberry anthocyanin freeze-dried powder prepared in the preparation example 1 and a common bombax flower extract, wherein the weight ratio of the blueberry anthocyanin freeze-dried powder to the common bombax flower extract is consistent with that of the composition in the example 1, and the total amount of the composition is consistent with that of the composition in the example 1.
Comparative example 5
The composition is prepared by uniformly mixing and stirring the blueberry anthocyanin freeze-dried powder prepared in the preparation example 1 and the oriental cherry extract, wherein the weight ratio of the blueberry anthocyanin freeze-dried powder to the oriental cherry extract is consistent with that of the composition in the example 1, and the total amount of the composition is consistent with that of the composition in the example 1.
Comparative example 6
This example provides a composition prepared by mixing and stirring oriental cherry extract and kapok extract uniformly, wherein the weight ratio of the two is the same as that of example 1, and the total amount of the composition is the same as that of example 1.
Test example 1
ABTS was performed on the compositions prepared in examples 1 to 6 and comparative examples 1 to 6, respectively+Measurement of the scavenging ability, measurement of DPPH scavenging ability, collagenase inhibition test, ElastinThe method for testing the inhibition of the protease comprises the following steps:
(1)ABTS+determination of the scavenging capacity:
ABTS is oxidized into green ABTS under the action of proper oxidant+ABTS in the Presence of an antioxidant+The production of (A) is inhibited, and the total antioxidant capacity of the sample can be determined and calculated by measuring the absorbance of ABTS at 734 nm.
The following reagents were prepared separately:
(ii) 2.45mmol/L Potassium persulfate: 0.662g of potassium persulfate, and the volume is adjusted to 1000mL by water;
7mmol/L ABTS stock solution: 0.192g of ABTS is subjected to constant volume to 50mL by using 2.45mmol/L potassium persulfate, and is stored at 20 ℃ in a dark place for 12-16h for use, so that the ABTS can be stabilized for 3-4 days;
(iii) 0.2mol/L PBS (pH 7.4): mixing 19mL of 0.2M sodium dihydrogen phosphate solution and 81mL of 0.2M disodium hydrogen phosphate solution to obtain the mixture;
(iv) 10mmol/L PBS (pH 7.4): diluting 50mL of 0.2mmol/L PBS (pH 7.4) with water to 1000mL to obtain the final product;
positive control stock solution: 2.5mmol/L VC ethanol solution or 5mmol/L VC PBS solution;
sixthly, the test sample is dissolved into the solution with the concentration of 5, 2.5, 1.25, 0.833, 0.625 and 0.5mg/mL by using distilled water.
The ABTS stock solution was diluted 40-50 times with 10mmol/L PBS (pH 7.4) to give an ABTS working solution at 734nm absorbance of 0.7. + -. 0.02(30 ℃ C.).
Respectively sucking 5mL ABTS working solution and 50 μ L sample solution into a test tube with a plug, oscillating for 10s, standing at 30 deg.C for 6min, and measuring absorbance A at 734nm1(ii) a Respectively sucking 5mL PBS buffer solution and 50 μ L sample solution into a test tube with a plug, oscillating for 10s, standing at 30 deg.C for 6min, and measuring absorbance A at 734nm2(ii) a Respectively sucking 5mL ABTS working solution and 50 μ L PBS buffer solution into a test tube with a plug, oscillating for 10s, standing at 30 deg.C for 6min, and measuring absorbance A at 734nm3(ii) a 3 replicates (presented as mean) were made for each sample. ABTS was calculated as follows+Clearance (%), and the IC50 value was further calculated.
The results are shown in table 1:
TABLE 1
(2) DPPH clearance measurement:
DPPH, also known as 1, 1-diphenyl-2-trinitrophenylhydrazine, is a very stable free radical with a nitrogen center, and the stability of DPPH is mainly caused by steric hindrance of 3 benzene rings with resonance stabilization, so that unpaired electrons on the nitrogen atom in the middle cannot play the role of electron pairing. Its absolute ethyl alcohol solution is purple, and has maximum absorption at wavelength of 517nm, and its absorbance and concentration are in linear relation. When a radical scavenger is added thereto, DPPH may be combined with or substituted for the radical scavenger, whereby the radical scavenging ability can be evaluated by decreasing the number of radicals, decreasing the absorbance, and decreasing the color of the solution.
Preparing 0.2mmol/L DPPH-absolute ethanol solution; preparing a sample solution with the concentration of 5000 mug/mL; respectively diluted to 625, 500, 250, 166, 125 and 100 mu g/mL. VC was used as a positive control sample.
Respectively sucking 2mL sample solution and 2mL DPPH solution into a test tube with a plug, mixing uniformly, reacting for 30min in a dark place, and measuring the light absorption value A at the wavelength of 517nm1(ii) a Respectively absorbing 2mL of sample solution and 2mL of absolute ethyl alcohol in a test tube with a plug, uniformly mixing, reacting for 30min in a dark place, and measuring the light absorption value A at the wavelength of 517nm2(ii) a Respectively sucking 2mL of DPPH solution and 2mL of absolute ethanol into a test tube with a plug, uniformly mixing, reacting for 30min in a dark place, and measuring the light absorption value A at the wavelength of 517nm0(ii) a 3 replicates (presented as mean) were made for each sample. According toABTS was calculated by the following formula+Clearance (%), and the IC50 value was further calculated.
The results are shown in Table 2.
TABLE 2
| Group of | IC50(μg/mL) |
| Example 1 | 4.09 |
| Example 2 | 5.06 |
| Example 3 | 4.96 |
| Example 4 | 17.94 |
| Example 5 | 17.69 |
| Example 6 | 18.91 |
| Comparative example 1 | 50.67 |
| Comparative example 2 | 60.94 |
| Comparative example 3 | 69.18 |
| Comparative example 4 | 20.69 |
| Comparative example 5 | 25.64 |
| Comparative example 6 | 26.16 |
| VC | 3.17 |
(3) Collagenase inhibition test:
the substance produced by the action of the collagenase on the FALGPA has the absorption at 335nm, and the activity of the collagenase is examined by monitoring the absorption value at 335 nm. The collagenase inhibitory effect of individual samples was determined spectrophotometrically using FALGPA as a substrate.
Containing 0.4M NaCl and 0.01M CaCl20.05M glycine buffer (pH 7.5); dissolving collagenase type I by using glycine buffer solution to prepare 1.1U/mL collagenase (ChC: 125U/mg); glycine buffer was used for solubilization to give 1mM FALGPA (M ═ 476.52); the positive control is resveratrol dissolved in absolute ethyl alcohol.
Incubating 50 μ L of the sample solution with 20 μ L of LChC solution and 60 μ L of glycine buffer for 20min at 37 ℃; 50 μ L of FALGPA solution was added to initiate the reaction. For the sample blank, glycine buffer was added instead of FALGPA solution. After incubation at 37 ℃ for 30min, the absorbance was measured at 335 nm. The specific grouping is shown in the following table:
for each sample, 3 replicates (presented as an average) were prepared and the collagenase inhibition (%) was calculated according to the following formula and further the IC50 value was calculated.
The results of the ChC activity inhibition ratio (%) < 1- (sample group-blank group)/(negative group-negative blank group) (%) are shown in table 3.
TABLE 3
(4) Elastase inhibition assay:
elastase acts on MAAPVN to generate p-nitroaniline, which absorbs at 410nm and is yellow, and the activity of elastase is examined by monitoring the release of p-nitroaniline at 410 nm. Individual samples were assayed spectrophotometrically for elastase inhibition using MAAPVN as the substrate.
Preparing a reagent: 0.1mol/L Tris (M ═ 121.14): taking 0.606g of Tris, and using deionized water to fix the volume to 50 mL; 0.1mol/L HCl (M ═ 36.5): taking 0.18mL of HCl, and fixing the volume to 50mL by using deionized water; 0.05mol/L Tris-HCl buffer (pH 8.0): taking 50mL of 0.1mol/L Tris and 29.2mL of 0.1mol/L HCl, mixing, and diluting deionized water to 100 mL; 5mmol/L MAAPVN (M ═ 590.63, sigma): 0.0295g was taken in 10mL of dimethyl sulfoxide (MAAPVN has a maximum solubility of 0.5mg/mL in water, readily soluble in DMSO); 0.9U/mL elastase (30U/mg): taking 0.015g of elastase, and fixing the volume to 500mL by using deionized water; the positive control was sevelamer sodium: dissolution was performed using 50% DMSO.
mu.L Tris-HCl (pH 8.0), 50. mu.L elastase and 50. mu.L sample solution, shaking, pre-incubation at 25 ℃ for 20min, adding 50. mu.L 5mmol/L MAAPVN solution, shaking, pre-incubation at 25 ℃ for 60min, and detecting absorbance at 410nm with a microplate reader. The specific grouping is shown in the following table:
3 replicates (presented as an average) were made for each sample and the elastase inhibition (%) was calculated according to the following formula and further the IC50 value was calculated.
The results of elastase inhibition (%) of 1- (sample group-blank group)/(negative group-negative blank group) (%) are shown in table 4.
TABLE 4
As can be seen from the data in tables 1 to 4: compared with a comparative example, the basic composition with the lip wrinkle fading effect has more remarkable effects of clearing free radicals, inhibiting elastase and inhibiting collagenase through the synergistic cooperation of the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract. And the preparation process of the blueberry anthocyanin freeze-dried powder can also influence the effects.
The avocado oil referred to in the following application examples was purchased from the Wen ling under the designation 549; aloe gel juice is purchased from Sichuan' an four seasons, and has a product number of SJ-LUNJ; vitamin C was purchased from Huayue chemical, having a product number of HNHUAYUE 0403; the honey extract is purchased from Mixue princess with the product number of 8000210102; beeswax was purchased from a money order, cat # 000898.
Application example 1
The application example provides a blueberry anthocyanin lipstick with a lip line fading effect, which comprises the following components: 4 parts of blueberry anthocyanin base composition prepared in example 1, 20 parts of avocado oil, 15 parts of aloe gel juice, 10 parts of vitamin C, 12 parts of honey extract and 60 parts of beeswax. The preparation method comprises the following steps:
(1) mixing blueberry anthocyanin freeze-dried powder with avocado oil, heating to 60 ℃, and uniformly stirring;
(2) mixing beeswax with the product of the step (1), heating to 80 ℃, and uniformly stirring;
(3) mixing the product of step (2) with flos Bombacis Malabarici extract, Oriental cherry flower extract, Aloe gel juice, vitamin C, and Mel extract, stirring at 25 deg.C, and pouring.
Application examples 2 to 6
The application example provides five blueberry anthocyanin lipsticks with the lip line fading effect, and the components of the blueberry anthocyanin lipstick are different from those of the application example 1 only in that the blueberry anthocyanin basic composition prepared in the example 1 is respectively replaced by the blueberry anthocyanin basic compositions prepared in the examples 2-6. The preparation method thereof was kept consistent with application example 1.
Application example 7
The application example provides a blueberry anthocyanin lipstick with the lip line fading effect, and the components of the blueberry anthocyanin lipstick are different from those of application example 1 only in that avocado oil is used for replacing sunflower seed oil. The preparation method thereof was kept consistent with application example 1.
Comparative application examples 1 to 6
The present application example provides six lipsticks, the components of which are different from those of application example 1 only in that the blueberry anthocyanin base composition prepared in example 1 is replaced with the products of comparative examples 1 to 6, respectively. The preparation method thereof is referred to the method in application example 1.
Test example 2
And (3) safety evaluation:
single open application tests were performed on the lipstick products prepared in application examples 1-7 and comparative application examples 1-6: 130 female volunteers with healthy skin and the age of 20-40 years are selected as subjects, 10 persons in each group are selected, an area of 1cm multiplied by 1cm is taken on the inner side of the left forearm of the volunteer to be used as a tested part, the same part on the inner side of the right forearm is taken to be coated with a placebo cream, the change of the skin appearance of the subjects is observed, and the judgment standard of the skin reaction grade is shown in the following table:
| grade of reaction | Skin reactions |
| Has no irritation | No reaction (negative) |
| Weak stimulation effect | Erythema and edema of the skin |
| Moderate stimulation | Obvious erythema, edema and herpes appear on the skin |
| Strong stimulation effect | The skin has obvious erythema, edema and herpes and the reaction exceeds the tested part |
The results are shown in Table 5:
TABLE 5
From the results in Table 5, it can be seen that: the lipstick with the lip wrinkle fading effect has good safety and no stimulation.
Test example 3
Evaluation of lip gloss reducing effect:
lip gloss reduction evaluation was performed on the lipstick products prepared in application examples 1-7 and comparative application examples 1-6: selecting 130 female volunteers with lips aged 20-40 as subjects, wherein each group comprises 10 female volunteers, obtaining lip print of the lips of the subjects by using silicone, then respectively coating the lips of the subjects with the same amount of products, 2 times per day for 21 days, obtaining the lip print of the lips of the subjects after 21 days, testing the lip print depth by using a confocal microscope, and calculating the percentage of depth reduction, wherein the results are shown in table 6:
TABLE 6
From the data in table 6, it can be seen that: compared with a comparative application example, the lipstick with the lip wrinkle fading effect provided by the invention has the advantage that the lip wrinkle fading effect is more remarkable through the synergistic cooperation of the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract. And the preparation process of the blueberry anthocyanin freeze-dried powder also influences the efficacy of the final product.
Test example 4
Evaluation of sensory effect of consumers:
consumer sensory evaluation was performed on the lipstick products prepared in application examples 1 to 7 and comparative application examples 1 to 6: selecting 130 female volunteers with age of 20-40 years and lip striae as subjects, coating equal amount of products on lips of the subjects for 10 persons in each group, respectively coating the same amount of products on the lips of the subjects, 2 times every day for 21 days continuously, evaluating the lip striae fading effect of the subjects before and after using the lipstick after 21 days, and dividing the evaluation result into 3 grades, namely, the lip striae fading effect is good, general and ineffective, and the results are shown in table 7:
TABLE 7
| Group of | Better effect (human) | Effect in general (human) | No effect (human) |
| Application example 1 | 10 | 0 | 0 |
| Application example 2 | 9 | 1 | 0 |
| Application example 3 | 10 | 0 | 0 |
| Application example 4 | 8 | 2 | 0 |
| Application example 5 | 8 | 1 | 1 |
| Application example 6 | 8 | 1 | 1 |
| Application example7 | 7 | 1 | 2 |
| Comparative application example 1 | 5 | 5 | 0 |
| Comparative application example 2 | 3 | 5 | 2 |
| Comparative application example 3 | 1 | 5 | 4 |
| Comparative application example 4 | 5 | 5 | 0 |
| Comparative application example 5 | 4 | 5 | 1 |
| Comparative application example 6 | 3 | 7 | 0 |
From the data in table 7, it can be seen that: compared with a comparative application example, the lipstick with the lip wrinkle fading effect provided by the invention has the advantage that the lip wrinkle fading effect is more remarkable through the synergistic cooperation of the blueberry anthocyanin freeze-dried powder, the kapok extract and the oriental cherry extract. And the preparation process of the blueberry anthocyanin freeze-dried powder also influences the efficacy of the final product.
The applicant states that the present invention is illustrated by the above examples, but the present invention is not limited to the above examples, that is, the present invention does not mean that the present invention must be implemented by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (10)
1. A blueberry anthocyanin base composition with a lip line fading effect is characterized by comprising: blueberry anthocyanin freeze-dried powder, kapok extract and oriental cherry extract.
2. The blueberry anthocyanin base composition of claim 1, wherein the blueberry anthocyanin base composition comprises, in parts by weight: 1-2 parts of blueberry anthocyanin freeze-dried powder, 0.5-1 part of kapok extract and 0.5-1 part of oriental cherry extract.
3. The blueberry anthocyanin base composition as set forth in claim 1 or claim 2, wherein the blueberry anthocyanin freeze-dried powder is prepared by a preparation method comprising the following steps:
(S1) homogenizing blueberries and sieving to obtain blueberry pulp;
(S2) freeze-drying the blueberry pulp into blueberry powder;
(S3) performing microwave extraction by taking an ethanol water solution as an extraction solvent to obtain a blueberry anthocyanin extracting solution;
(S4) carrying out condensation rotary evaporation on the blueberry anthocyanin extracting solution to remove the solvent, and then carrying out freeze drying to obtain the blueberry anthocyanin freeze-dried powder.
4. The blueberry anthocyanin base composition of claim 3, wherein the screening mesh size of step (S1) is 100-140 mesh;
preferably, the concentration of the ethanol aqueous solution of the step (S3) is 40 to 60%, preferably 45 to 55%.
5. The blueberry anthocyanin base composition of claim 3 or 4, wherein the liquid-solid ratio of the aqueous ethanol solution to the blueberry powder in the step (S3) is 10-20 mL/g;
preferably, the power of the microwave extraction in the step (S3) is 400-600W, and the time is 10-20 min.
6. The blueberry anthocyanin lipstick with the lip line fading effect is characterized by comprising the following preparation raw materials: the blueberry anthocyanin base composition of any one of claims 1-5, vegetable fat, aloe vera gel juice, vitamin C, honey extract, and beeswax.
7. The blueberry anthocyanin lipstick with the lip line fading effect as claimed in claim 6, wherein the blueberry anthocyanin lipstick is prepared from the following raw materials in parts by weight: 1-2 parts of blueberry anthocyanin freeze-dried powder, 0.5-1 part of common bombax flower extract, 0.5-1 part of cherry blossom extract, 15-20 parts of avocado oil, 10-15 parts of aloe gel juice, 10-15 parts of vitamin C, 10-15 parts of honey extract and 50-70 parts of beeswax.
8. The blueberry anthocyanin lipstick with lip line fading effect as claimed in claim 6 or claim 7, wherein the vegetable oil is avocado oil;
preferably, the blueberry anthocyanin lipstick further comprises natural perfume.
9. The preparation method of the blueberry anthocyanin lipstick with the lip line fading effect as claimed in any one of claims 6 to 8, wherein the preparation method comprises the following steps:
(1) mixing the blueberry anthocyanin freeze-dried powder with vegetable oil, heating and stirring;
(2) mixing beeswax with the product of the step (1), heating and stirring;
(3) mixing the product obtained in step (2) with kapok extract, oriental cherry extract, aloe gel juice, vitamin C and honey extract, stirring, and pouring.
10. The method of claim 9, wherein the heating in step (1) is heating to 55-65 ℃;
preferably, the heating in the step (2) is heating to 75-85 ℃;
preferably, the stirring of step (3) is carried out at 15-40 ℃.
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