CN1129252A - Povidone-iodine solid cleansing preparation - Google Patents

Abstract

The present invention relates to a stable solid cleaning agent with bactericidal ability, which contains povidone-iodine, synthetic detergent, sodium sulfate, alcohol ethoxylate and other auxiliary agents.

Description

Povidone-iodine solid cleansing preparation

The present invention relates to contain stable bactericide product and its preparation method that Iodophor and synthetic detergent clean the solid form of base-material.

More particularly, the present invention relates to stable and cleaning article moisture resistance of stick or sheet form, it contains Iodophor, synthetic detergent, sodium sulfate, fatty alcohol ethoxylate and other auxiliary, as stablizer, softening agent, stiffening agent, tinting material or whitening agent and spices, these goods have the character that fungicidal activity, wettability, foaming and whipability and outward appearance can keep for a long time.

Iodophor is known broad-spectrum antimicrobial agent, owing to its outstanding character is widely used.It can be anti-effectively positive the and γ negative bacteria of γ, comprise Rhodopseudomonas bacterium and tubercule bacillus and antiviral, comprise bleb and cause the fearful HIV of AIDS.It can also resist mould and yeast and the anti-effectively particularly protozoon of Trichomonas that causes sportsmen's pedopathy, moniliosis and serious seborrheic dermatitis effectively.

In addition, Iodophor has quick function of killing microorganism, is almost contacting the organism that can kill sensitivity within 15 to 60 seconds.Itself in addition under lower concentration, most organic fungicidal effectiveness is also reached 100%.Iodophor also has good drug-resistant capability, is comparatively safe and proved well by document at the trial.Because these excellent character of Iodophor, found that it is widely used in the various products such as hospital, clinical, hotel, restaurant and among family and the personal care product.

Known general solid bar or flaky cleaning products are better than the cleaning products of liquid form.Consider the economy of product, solid bar is preferably, because compare with the cleaning products of liquid form, its unit weight expense is lower and have a longer cleaning mileage (that is, the product of unit weight can be done more cleaning).In addition, it does not need to use dispersion agent to avoid overusing or loss.Solid bar also very lightly is easy to use.In addition, it can be not contaminated than stablizing.

Existing Iodophor cleaning article is liquid and solid form two kinds.Yet obviously solid form is preferably, because except above-mentioned general advantage, because it is a relatively dry, thereby the fungicidal activity of Iodophor can be kept the long time.

Yet because Iodophor has hyperergy, it is difficult therefore seeking suitable fully cleaning base-material.Iodophor be tart and can with any alkali substance reaction, therefore cleaning base-material, must to have PH be 7 or lower.This base-material must be compatible in others and iodine shape also, and for example this base-material can not contain a large amount of metallic impurity, because the iodine in the Iodophor is easy to react with metal ion.Therefore, because the reactivity of conventional coconut, palm and the neat soap high pH value of these clean-out system inherent and they and iodine thereby be not suitable for being used.Moreover, can be with the iodine direct reaction, resemble starch and other glycan material and also should not exist.

Synthetic detergent uses as the cleaning base-material of Iodophor.The mixture that has used Sodium Lauryl Sulphate BP/USP and lauryl sodium sulfosuccinate by the synthetic detergent base material formulation of German Schimmer and Schwartz company exploitation as tensio-active agent, use hexadecanol, stearic acid and paraffin as moisture-proof barrier.The Neka company of Israel has also used hexadecanol, stearic acid and paraffin as moisture-proof barrier, but can be used in combination with single hydroxyethyl sulfonate surface active agent composition.At the US 3 that transfers Synergistics Inc.of New York, in 687,855, (PEG 1 to add polyoxyethylene glycol in the prescription that contains tensio-active agent and hexadecanol, 500～6,000) as Iodophor supplement (in order to improve the dispersed and stability of Iodophor).

Although the said products has advantage, find that they obviously are designed to the temperate zone country of low humidity condition.When it was used for those tropical high humidity climates national, these absorbent products in use showed undue softening and follow fungicidal activity to reduce.

Therefore, in order to obtain satisfied product, must reduce to minimum with the softening trend of synthetic detergent with by the trend of the moisture absorption in the air.Yet, in the prior art instruction adopt a kind of hardness that can improve stick and water resisting property and other required character of Iodophor cleaning products do not had the remarkable or effective solution of otherwise impact.

In above-mentioned existing prescription, add water-insoluble meal, can not reach required effect as lime carbonate, talcum, calcium sulfate, Magnesium Stearate/calcium, wilkinite and silicate.Talcum, calcium stearate/magnesium and wilkinite can not provide moisture-proof role, and they can not improve the hardness of stick.Use lime carbonate or water glass can obtain required stick hardness, but these two kinds of materials rise to greater than 7 the PH of product, so the stability of Iodophor is affected.The stability of Iodophor also is subjected to the influence of technical grade calcium sulfate, because technical grade calcium sulfate containing metal impurity.

When mixing water-soluble substances sodium sulfate in the synthetic detergent base material formulation, the product that obtains is hard and have moisture resistance preferably, but it is more crisp, and its foaming property is unsatisfactory.The effect that does not reach for the change that overcomes technology that these unfavorable character makes and prescription.

By making composition roll a grinding operation that replaces standard through twice, make processing (as in mold pressing, roll, push and print) difficulty in the brittle prod slightly solves, can produce and can push and print and not have and split broken more blocky feasible product.Yet in addition, it is higher to roll cost for twice, and foaming property is not improved to required level.

About the change of prescription, comprise adding the material that increases whipability and plasticising character, do not obtain required character.Add glycerine and can obtain more blocky product, but this product is too hard, screw extrusion press is difficult to operation.Whipability improves, but the easier infiltration moisture content of product, therefore can not realize reducing the purpose of the stick property of softening.The lipid acid of medium chain can not mix well with the synthetic detergent base-material, and single ethanol amide and diglycollic amide are owing to their high pH value also is not suitable for simultaneously.

Beyond thought discovery is when be incorporated as preferred 10%-30% sodium sulfate of total composition amount and 0.5-1.O%C in above-mentioned known synthetic detergent base-material ₁₂-C ₁₈During fatty alcohol ethoxylate, the stable Iodophor solid phase prod of the hardness that can improve and water resisting property.In order to improve the dispersiveness of fatty alcohol ethoxylate in the synthetic detergent base-material, at first it is mixed with the ethanol of equal portions.

For said composition, the foaming property of this product and processibility have obtained the improvement of highly significant.Simultaneously, it and Iodophor and other auxiliary of being present in the cleaning article are that physics is compatible with chemistry.

Therefore the invention provides stable solid cleaning article, it comprises the composition that contains following component: 2-10% Iodophor, 25-60% synthetic detergent, 10-30% sodium sulfate, 0.5-1.0%C ₁₂-C ₁₈Fatty alcohol ethoxylate and 31.5-57.5% other auxiliary are as polyoxyethylene glycol, hexadecanol, paraffin, stearic acid, titanium dioxide and essence.Make said composition obtain stick or sheet cleaning products by the soap grinding operation of standard.

The auxiliary that uses in the present composition is to the product increase or give some required character.For example, Macrogol 4000 has improved the distributivity of Iodophor in product, when using product, makes the more even release of this sterilizing agent thus.Hexadecanol and paraffin are as moisture-proof barrier and softening agent.Stearic acid has improved foaming stability simultaneously as tackiness agent.Titanium dioxide is known opalizer and whitening agent, gives product neat and blocky outward appearance.Spices is to be used to hide or change some unfavorable smells that come from some component, by obtaining the character conforming acceptable smell designed with product a bit.

Preferred this solid phase prod is by the formulation that contains following component: 2-10% Iodophor, 25-60% surfactants/detergents (consists of 12-30% Sodium Lauryl Sulphate BP/USP, 12-30% lauryl sodium sulfosuccinate and/or 25-60% hydroxyethyl sulfonate), 10-28% Macrogol 4000,10-30% sodium sulfate, 5-10% hexadecanol, 6-12% stearic acid, 10-30% sodium sulfate, 5-10% hexadecanol, 6-12% stearic acid, 10-15% paraffin, 0.5-1.0%C ₁₃Fatty alcohol ethoxylate, 0.5-1.0% titanium dioxide and 0-1.0% essence.

Iodophor solid cleaning products provided by the invention does not have the unsatisfactory properties of known cleaning products.This solid bar or flaked product even the area that is used for those tropical high humidity climates also can keep its outward appearance and clean character, keep the fungicidal activity of Iodophor simultaneously.

Obviously, though sodium sulfate is water dissolvable, by following mechanism, it provides moisture-proof barrier for the synthetic detergent base-material:

1. this strong electrolyte that exists in soap base matter makes the crystallized form of surfactant be changed into the δ phase of low infiltration form mutually by β.

2. sodium sulfate specific surface promoting agent is more soluble in water, and its specific surface promoting agent is preferentially dissolved by moisture film.

When the synthetic detergent bars of prior art in use became wet, thin moisture film just remained on the surface of stick.The moisture film of this covering stick dissolves following surfactant then, and last formation is retained in the lip-deep immobilized gel of stick.This gel is a high-hygroscopicity, and under high humidity, it then absorbs more moisture content, and this moisture content dissolves more multilist face active substance conversely from synthetic detergent bars.This process continues to carry out, and changes soft gelatinous mass into up to whole synthetic detergent bars.

When sodium sulfate was present in the synthetic detergent bars, it was dissolved in the lip-deep moisture film of stick.Be present in sodium and sulfate ion in the moisture film, " it is soluble in water that 5 effects of saltouing have further hindered tensio-active agent owing to it.Therefore, the amount that is dissolved in the tensio-active agent in the moisture film is reduced to minimum, has significantly reduced the formation of hygroscopic tensio-active agent gel thus.

Preparation is according to the Iodophor cleaning products with solid bar form of following composition of the present invention, and tests by the description in following examples:

Raw produce; raw products product product Iodophor 7.5% 5.0% 2.0% total surfactants/wash agent alive 32.0% 36.0% 40.0% NaLS (0.0%) (0.0%) (20.0%) lauryl sodium sulfosuccinate (0.0%) (0.0%) (20.0%) hydroxyethyl sulfonates (32.0%) (36.0%) (0.0%)

Raw produce; raw products product product Macrogol 4000 25.0% 15.0% 10.0% sodium sulphate 20.0% 25.0% 13.5% cetanols 5.0% 2.5% 10.0% stearic acid 8.0% 9.0% 10.0% paraffin 0.0% 5.0% 13.0% alcohol ethoxylates 1.0% 1.0% 0.5% titanium dioxide 0.5% 0.5% 1.0% essence 1.0% 1.0% 0.0%

Embodiment A

7.5 parts of Iodophor powder are added in 25 parts of Macrogol 4000s in the amalgamator.Two components were mixed about 1 minute.Then 32 parts of hydroxyethyl sulfonate thin slices, 20 parts of sodium sulfate, 5 parts of hexadecanols, 8 parts of stearic acid thin slices and 0.5 part of titania powder are added in Iodophor/polyoxyethylene glycol mixture.All flours were done mixed 3 minutes again.1 part of fatty alcohol ethoxylate and 1 part of essence in 50% ethanolic soln slowly are distributed in the dried mixture.After adding.Continue restir 5 minutes, end whipping step.

Use efficient four roller runner millings that the mixture that merges is milled.The temperature of the patch in this roll shape runner milling should be 102-106 °F.Use the duplex vacum plodder that is equipped with two helical turbines with this patch press strip, die mould and extruding of milling then.The product of this die mould is squeezed into the successive column form object then, cuts and be printed as stick then.The bar deblocking temperature that squeezes out is 102-106 °F.

In addition, the Iodophor cleaning products for preparing prescription B and C by above description.

Resist the tests of various bacterial strain bacteriums with 0.1%, 0.01% and 0.001% solution of products obtained therefrom, as to streptococcus aureus, chain pearl Pseudomonas, klebsiella, salmonella, aerobacter, Rhodopseudomonas, intestinal bacteria and tubercule bacillus; White candiyeast to Mycophyta; Trichomonas vaginalis to the protozoon class; With influenza virus, rubella, bleb and HIV are done experiment.The result of gained is the representative data of the microorganism active of Iodophor.

When carrying out storage test, after storage 24 months, can keep 90 percent fungicidal effectiveness.

Other physical properties is as the standard of bubbling, hardness painted and stick also meets formulation.After through 24 months, these physical propertiess are not significant to be changed.

Press the practical situations of product, till product is exhausted, do not find the unfavorable ruckbildung of stick.

It should be understood that above embodiment just exemplifies explanation the present invention, and the present invention without limits.

Claims (5)

1. the stable sterilization cleaning combination of a solid form, it contains 2-10% Iodophor, 25-60% synthetic detergent, 10-30% sodium sulfate, 0.5-1.0% C ₁₂-C ₁₈Fatty alcohol ethoxylate and 31.5-57.5% auxiliary.

2. according to the composition of claim 1, wherein synthetic detergent comprises 25-60% hydroxyethyl sulfonate.

3. according to the composition of claim 1, wherein synthetic detergent comprises 1: 1 mixture of Sodium Lauryl Sulphate BP/USP and lauryl sodium sulfosuccinate.

4. according to the composition of claim 1, it is that stick forms.

5. according to the composition of claim 1, wherein auxiliary contains 5-10% hexadecanol, 6-12% stearic acid and 0-15% paraffin.