CN112915250A - Low-viscosity isolation acrylic pressure-sensitive adhesive for wound surface and preparation method thereof - Google Patents
Low-viscosity isolation acrylic pressure-sensitive adhesive for wound surface and preparation method thereof Download PDFInfo
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- CN112915250A CN112915250A CN202110129305.2A CN202110129305A CN112915250A CN 112915250 A CN112915250 A CN 112915250A CN 202110129305 A CN202110129305 A CN 202110129305A CN 112915250 A CN112915250 A CN 112915250A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1804—C4-(meth)acrylate, e.g. butyl (meth)acrylate, isobutyl (meth)acrylate or tert-butyl (meth)acrylate
Abstract
The invention relates to a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces and a preparation method thereof, wherein the pressure-sensitive adhesive comprises, by mass, 100%, 0.5% -4.5% of a component B, 10% -30% of a component C, and the balance of a component A; wherein, the component A is a water-based polyacrylic acid polymer, the component B is an additive with a crosslinking function, and the component C is an additive component with a thickening function. The low-viscosity isolation acrylic pressure-sensitive adhesive for the wound surface, which is prepared by the invention, has low viscosity and good isolation, can be completely stripped off during stripping, and is not easy to leave adhesive residues; the skin care product is flexible to use, good in compatibility with skin, free of stimulation to skin and allergy, good in experience effect of patients and wide in application range.
Description
Technical Field
The invention belongs to the field of medical supplies, relates to a pressure-sensitive adhesive, and particularly relates to a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces and a preparation method thereof.
Background
Acrylic pressure sensitive adhesives are widely used in a variety of pressure sensitive tapes and medical dressings, such as wound dressings. Wound dressings are articles used to pack wounds to cover sores, wounds, or other damaged materials. A typical wound dressing structure includes a layer of pressure sensitive adhesive coated on a backing, and a release film attached to the adhesive side. Some wound dressings are water resistant but vapor impermeable, and some are both water resistant and vapor permeable. In recent years, with scientific progress and improvement of the living standard of people, the latter wound dressing which is waterproof and breathable is more and more emphasized by people.
Pressure-sensitive adhesives are used in a variety of applications requiring adhesion to the skin, such as medical tapes, wound or surgical dressings, for securing devices or relatively heavy dressings such as indwelling needles, intravenous catheters, etc. to the skin but the problems of adhesion of pressure-sensitive adhesives to the skin are compounded by the greater differences in skin surface properties, mechanical properties, especially dynamic mechanical properties, from other materials due to the flatness of the skin surface and the presence of hair, secretions, stratum corneum.
In the existing dressing products, in order to prevent granulation tissues from growing into the dressing or scabbing to adhere to the dressing in the wound healing process, and cause secondary damage to the wound when the dressing is removed, silicone gel and vaseline are selected for isolation, but the silicone gel is high in cost, and the vaseline is oily and is not dry and is easy to pollute clothes of patients.
Disclosure of Invention
The invention aims to solve the defects that the cost of isolating components of the existing dressing products is high or clothes of patients are easily polluted, and provides a low-viscosity isolating acrylic pressure-sensitive adhesive for wound surfaces.
Another object of the present invention is to provide a method for preparing the acrylic pressure sensitive adhesive.
In order to achieve the purpose, the invention adopts the following technical scheme:
a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces comprises, by mass, 100%, 0.5-4.5% of a component B, 10-30% of a component C, and the balance of a component A; wherein, the component A is a water-based polyacrylic acid polymer, the component B is an additive with a crosslinking function, and the component C is an additive component with a thickening function.
In the invention, the component B is used for adjusting the crosslinking degree of the component A so as to adjust the viscosity of the glue and the peeling strength, 0.5-4.5% of crosslinking agent is selected in the invention, if the dosage of the crosslinking agent is too small, the viscosity of the crosslinking agent is too large, and secondary damage is caused to the wound surface when the dressing is uncovered; if the amount of the cross-linking agent is too much, the dressing is not sticky and cannot be attached to the wound surface;
the component C plays a role in thickening, and can feel smooth when contacting the seepage of a wound surface, and the adhesive layer with the addition of less than 10 percent of the component C can not feel smooth after absorbing the seepage, so that the isolation effect can not be achieved. The addition amount of the component C is more than 30 percent, the adhesive layer becomes hard and is not suitable for wounds, so the content of the component C in the invention is 10 to 30 percent.
As a preferable scheme of the invention, the raw materials of the component A comprise the following components in parts by weight: 50-90 parts of soft monomer, 10-40 parts of hard monomer, 1-20 parts of functional monomer, 0.4-1.2 parts of emulsifier, 0.1-1 part of initiator, 0.1-1 part of buffering agent, 0.05-0.5 part of oxidant, 0.05-0.5 part of reducing agent and a plurality of parts of pH regulator.
As a preferred embodiment of the present invention, the soft monomer includes ethyl acrylate or butyl acrylate.
Preferably, the soft monomer is butyl acrylate.
As a preferred embodiment of the present invention, the hard monomer includes methyl acrylate or methyl methacrylate.
Preferably, the hard monomer is methyl methacrylate.
In a preferred embodiment of the present invention, the functional monomer comprises acrylic acid or hydroxyethyl acrylate, and the emulsifier comprises sodium lauryl sulfate, a mixture of polyol fatty acid ester and polyvinyl alcohol.
Preferably, the functional monomer is acrylic acid, and the emulsifier is a mixture of sodium dodecyl sulfate, polyol fatty acid ester and polyvinyl alcohol in a mass ratio of 1:1: 1.
In a preferred embodiment of the present invention, the initiator is ammonium persulfate, the buffer is sodium bicarbonate, the oxidant is tert-butyl hydroperoxide, and the reducing agent is sodium metabisulfite.
In a preferred embodiment of the present invention, the component B is an epoxy silane crosslinking agent.
As a preferred embodiment of the present invention, the component C is xanthan gum.
A preparation method of a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces comprises the following steps:
one) preparation of component A:
1) adding water and one tenth of emulsifier into a reaction system, stirring and dissolving, adding part of soft monomer, hard monomer and functional monomer, and emulsifying for 20-40 minutes;
2) continuously adding water into the reaction system in the step 1), stirring and dissolving the water and the rest of the emulsifier, adding the rest of the soft monomer, the hard monomer and the functional monomer, and pre-emulsifying for 55-65 minutes to prepare a pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 80-90 ℃, adding part of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 2-3 hours;
4) after all the pre-emulsion is added, the reaction is carried out for 140 minutes under the condition of heat preservation;
5) cooling to 55-65 ℃, adding an oxidant and a reducing agent, and stirring for reaction for 55-65 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7-8;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 140 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
In a preferred embodiment of the present invention, in step 1), the addition amounts of the soft monomer, the hard monomer and the functional monomer are one tenth of the addition amounts of the total soft monomer, the hard monomer and the functional monomer, respectively.
Compared with the prior art, the invention has the following beneficial effects:
1) the low-viscosity isolation acrylic pressure-sensitive adhesive for the wound surface, which is prepared by the invention, has low viscosity and good isolation, can be completely stripped off during stripping, and is not easy to leave adhesive residues;
2) the low-viscosity isolation acrylic pressure-sensitive adhesive for the wound surface is flexible to use, good in compatibility with skin, free of stimulation and allergy to the skin, good in experience effect of patients and wide in application range;
3) the preparation method has simple steps and low cost.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
In order to make those skilled in the art better understand the technical solution of the present invention, the following will clearly and completely describe the technical solution in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, shall fall within the scope of the present invention.
If not specified, all of the raw materials used in the present invention are commercially available.
In the present invention, "%" means mass fraction.
Example 1
The embodiment provides a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces, which comprises 0.5% of epoxy silane cross-linking agent, 10% of xanthan gum and 89.5% of component A; wherein, the component A is a water-based polyacrylic acid polymer, the component B is an additive with a crosslinking function, and the component C is an additive component with a thickening function.
The component A comprises the following raw materials in parts by weight: 50 parts of butyl acrylate, 10 parts of methyl methacrylate, 1 part of acrylic acid, 0.4 part of a mixture of lauryl sodium sulfate, polyol fatty acid ester and polyvinyl alcohol in a mass ratio of 1:1:1, 0.1 part of ammonium persulfate, 0.1 part of sodium bicarbonate, 0.05 part of tert-butyl hydroperoxide, 0.05 part of sodium metabisulfite and a pH regulator.
The preparation method comprises the following steps:
one) preparation of component A:
1) adding 10% of water and 10% of emulsifier into a reaction kettle, stirring and dissolving, then respectively adding 10% of soft monomer, hard monomer and functional monomer, and emulsifying for 20 minutes;
2) adding the remaining 90% of water into the reaction kettle in the step 1), stirring and dissolving the water and the remaining emulsifier, adding the remaining soft monomer, hard monomer and functional monomer, and pre-emulsifying for 55 minutes to prepare pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 80 ℃, adding 10% of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 2 hours;
4) after all the pre-emulsion is added, keeping the temperature and reacting for 100 minutes;
5) cooling to 55 ℃, adding an oxidant and a reducing agent, and stirring for reaction for 55 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 100 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
Example 2
This example provides a low-viscosity release acrylic pressure-sensitive adhesive for wound surface, which comprises 1.5% of epoxy silane cross-linking agent, 20% of xanthan gum, and 78.5% of component A.
The component A comprises the following raw materials in parts by weight: 75 parts of soft monomer butyl acrylate, 30 parts of hard monomer methyl acrylate, 10 parts of functional monomer acrylic acid, 0.6 part of mixture of lauryl sodium sulfate, polyol fatty acid ester and polyvinyl alcohol in a mass ratio of 1:1:1, 0.5 part of initiator ammonium persulfate, 0.6 part of buffer sodium bicarbonate, 0.15 part of oxidant tert-butyl hydroperoxide, 0.2 part of reducing agent sodium metabisulfite and a pH regulator.
The preparation method comprises the following steps:
one) preparation of component A:
1) adding 10% of water and 10% of emulsifier into a reaction kettle, stirring and dissolving, then respectively adding 10% of soft monomer, hard monomer and functional monomer, and emulsifying for 30 minutes;
2) adding the remaining 90% of water into the reaction kettle in the step 1), stirring and dissolving the water and the remaining emulsifier, adding the remaining soft monomer, hard monomer and functional monomer, and pre-emulsifying for 60 minutes to prepare pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 85 ℃, adding 10% of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 2 hours;
4) after all the pre-emulsion is added, keeping the temperature and reacting for 120 minutes;
5) cooling to 60 ℃, adding an oxidant and a reducing agent, and stirring for reacting for 60 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7-8;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 120 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
Example 3
This example provides a low-tack release acrylic pressure-sensitive adhesive for wound surfaces, which comprises 2.5% of an epoxy silane-based cross-linking agent, 25% of xanthan gum, and 72.5% of component A.
The component A comprises the following raw materials in parts by weight: 90 parts of soft monomer butyl acrylate, 40 parts of hard monomer methyl methacrylate, 20 parts of functional monomer hydroxyethyl acrylate, 1 part of lauryl sodium sulfate, 1.2 parts of mixture of polyol fatty acid ester and polyvinyl alcohol in a mass ratio of 1:1:1, 1 part of initiator ammonium persulfate, 1 part of buffer sodium bicarbonate, 0.5 part of oxidant tert-butyl hydroperoxide, 0.5 part of reducing agent sodium metabisulfite and a pH regulator.
The preparation method comprises the following steps:
one) preparation of component A:
1) adding 10% of water and 10% of emulsifier into a reaction kettle, stirring and dissolving, then respectively adding 10% of soft monomer, hard monomer and functional monomer, and emulsifying for 40 minutes;
2) adding the remaining 90% of water into the reaction kettle in the step 1), stirring and dissolving the water and the remaining emulsifier, adding the remaining soft monomer, hard monomer and functional monomer, and pre-emulsifying for 65 minutes to prepare pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 90 ℃, adding 10% of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 3 hours;
4) after all the pre-emulsion is added, keeping the temperature and reacting for 140 minutes;
5) cooling to 65 ℃, adding an oxidant and a reducing agent, and stirring for reacting for 65 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7-8;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 140 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
Example 4
The embodiment provides a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces, which comprises 3.5% of epoxy silane cross-linking agent, 30% of xanthan gum and 66.5% of component A;
the component A comprises the following raw materials in parts by weight: 75 parts of soft monomer butyl acrylate, 40 parts of hard monomer methyl methacrylate, 15 parts of functional monomer acrylic acid, 1 part of lauryl sodium sulfate, 1 part of mixture of polyol fatty acid ester and polyvinyl alcohol in a mass ratio of 1:1:1, 0.6 part of initiator ammonium persulfate, 0.4 part of buffer sodium bicarbonate, 0.35 part of oxidant tert-butyl hydroperoxide, 0.25 part of reducing agent sodium metabisulfite and a pH regulator.
The preparation method comprises the following steps:
one) preparation of component A:
1) adding 10% of water and 10% of emulsifier into a reaction kettle, stirring and dissolving, then respectively adding 10% of soft monomer, hard monomer and functional monomer, and emulsifying for 30 minutes;
2) adding the remaining 90% of water into the reaction kettle in the step 1), stirring and dissolving the water and the remaining emulsifier, adding the remaining soft monomer, hard monomer and functional monomer, and pre-emulsifying for 60 minutes to prepare pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 85 ℃, adding 10% of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 2 hours;
4) after all the pre-emulsion is added, keeping the temperature and reacting for 130 minutes;
5) cooling to 60 ℃, adding an oxidant and a reducing agent, and stirring for reacting for 60 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7-8;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 125 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
Example 5
The embodiment provides a low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces, which comprises 4.5% of epoxy silane cross-linking agent, 20% of xanthan gum and 75.5% of component A;
the component A comprises the following raw materials in parts by weight: 80 parts of soft monomer butyl acrylate, 35 parts of hard monomer methyl methacrylate, 10 parts of functional monomer acrylic acid, 0.8 part of mixture of lauryl sodium sulfate, polyol fatty acid ester and polyvinyl alcohol in a mass ratio of 1:1:1, 0.7 part of initiator ammonium persulfate, 0.6 part of buffer sodium bicarbonate, 0.25 part of oxidant tert-butyl hydroperoxide, 0.35 part of reducing agent sodium metabisulfite and a pH regulator.
The preparation method comprises the following steps:
one) preparation of component A:
1) adding 10% of water and 10% of emulsifier into a reaction kettle, stirring and dissolving, then respectively adding 10% of soft monomer, hard monomer and functional monomer, and emulsifying for 30 minutes;
2) adding the remaining 90% of water into the reaction kettle in the step 1), stirring and dissolving the water and the remaining emulsifier, adding the remaining soft monomer, hard monomer and functional monomer, and pre-emulsifying for 60 minutes to prepare pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 85 ℃, adding 10% of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 2 hours;
4) after all the pre-emulsion is added, keeping the temperature and reacting for 130 minutes;
5) cooling to 60 ℃, adding an oxidant and a reducing agent, and stirring for reacting for 60 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7-8;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 125 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
Comparative example 1, identical to example 1, except that the content of component B was 6.5%.
Comparative example 2, identical to example 1, except that the content of component B was 0.1%.
The wound surfaces prepared in examples 1-5 and comparative examples 1-2 were tested for adhesion using a low adhesion barrier acrylic pressure sensitive adhesive according to the GBT 31125 and 2014 adhesive tape initial adhesion test method annular method, and the results are shown in Table 1.
TABLE 1 results of the tack test
As can be seen from table 1, the low-viscosity isolating acrylic pressure-sensitive adhesive for wound surfaces of the present invention has low viscosity, can be completely peeled off during peeling, and is not easy to leave adhesive residues.
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that the foregoing and other changes, omissions and deviations in the form and detail thereof may be made without departing from the scope of this invention. Those skilled in the art can make various changes, modifications and equivalent arrangements, which are equivalent to the embodiments of the present invention, without departing from the spirit and scope of the present invention, and which may be made by utilizing the techniques disclosed above; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (10)
1. The low-viscosity isolation acrylic pressure-sensitive adhesive for the wound surface is characterized by comprising 0.5-4.5% of a component B, 10-30% of a component C and the balance of a component A, wherein the components B, C and C are calculated according to 100% of mass fraction; wherein, the component A is a water-based polyacrylic acid polymer, the component B is an additive with a crosslinking function, and the component C is an additive component with a thickening function.
2. A wound low-viscosity isolation acrylic pressure-sensitive adhesive as claimed in claim 1, wherein the component A comprises the following raw materials in parts by weight: 50-90 parts of soft monomer, 10-40 parts of hard monomer, 1-20 parts of functional monomer, 0.4-1.2 parts of emulsifier, 0.1-1 part of initiator, 0.1-1 part of buffering agent, 0.05-0.5 part of oxidant, 0.05-0.5 part of reducing agent and a plurality of parts of pH regulator.
3. A wound low adhesion release acrylic pressure sensitive adhesive as claimed in claim 2, wherein the soft monomer comprises ethyl acrylate or butyl acrylate.
4. A wound low adhesion release acrylic pressure sensitive adhesive as claimed in claim 2, wherein the hard monomer comprises methyl acrylate or methyl methacrylate.
5. A wound low adhesion release acrylic pressure sensitive adhesive as claimed in claim 2, wherein the functional monomer comprises acrylic acid or hydroxyethyl acrylate, and the emulsifier comprises sodium lauryl sulfate, a mixture of polyol fatty acid ester and polyvinyl alcohol.
6. A wound low-adhesion acrylic pressure-sensitive adhesive as claimed in claim 2, wherein the initiator is ammonium persulfate, the buffer is sodium bicarbonate, the oxidant is tert-butyl hydroperoxide, and the reducing agent is sodium metabisulfite.
7. A wound low-adhesion isolation acrylic pressure-sensitive adhesive as claimed in claim 1, wherein the component B is an epoxy silane crosslinking agent.
8. A low adhesion barrier acrylic pressure sensitive adhesive for wound dressing as claimed in claim 1, wherein component C is xanthan gum.
9. A process for preparing a low adhesion barrier acrylic pressure sensitive adhesive for wound dressing according to claim 1, comprising the steps of:
one) preparation of component A:
1) adding water and one tenth of emulsifier into a reaction system, stirring and dissolving, adding part of soft monomer, hard monomer and functional monomer, and emulsifying for 20-40 minutes;
2) continuously adding water into the reaction system in the step 1), stirring and dissolving the water and the rest of the emulsifier, adding the rest of the soft monomer, the hard monomer and the functional monomer, and pre-emulsifying for 55-65 minutes to prepare a pre-emulsion for later use; dissolving all initiators and buffers in water to prepare an initiator solution for later use;
3) heating to 80-90 ℃, adding part of the initiator solution obtained in the step 2), starting to add the pre-emulsion obtained in the step 2) at a constant speed when the reaction is carried out until blue fluorescence appears, and finishing adding the pre-emulsion after 2-3 hours;
4) after all the pre-emulsion is added, the reaction is carried out for 140 minutes under the condition of heat preservation;
5) cooling to 55-65 ℃, adding an oxidant and a reducing agent, and stirring for reaction for 55-65 minutes;
6) continuously cooling to below 40 ℃, adding a pH regulator, and regulating the pH value to 7-8;
7) discharging the glue for later use;
secondly) preparation and application of the low-viscosity isolation acrylic pressure-sensitive adhesive for wound surfaces:
and mixing the component A, the component B and the component C in proportion for 140 minutes, immersing gauze into glue for gluing, and drying the glued gauze to obtain the low-viscosity isolated gauze.
10. The method for preparing a low-viscosity isolating acrylic pressure-sensitive adhesive for wound surfaces as claimed in claim 9, wherein in the step 1), the addition amounts of the soft monomer, the hard monomer and the functional monomer are one tenth of the total addition amounts of the soft monomer, the hard monomer and the functional monomer respectively.
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