CN112891449A - Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae - Google Patents
Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention relates to the technical field of medical supplies, and discloses a traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae, which comprises a preparation method, 10-20 parts of ailanthus altissima bark, 10-20 parts of paris polyphylla, 10-20 parts of coptis chinensis and 10-20 parts of cortex dictamni, wherein the raw materials are subjected to ultrasonic extraction for 2-8 hours by using 50-95% ethanol (volume percentage) which is 10 times of the total weight of the raw materials, an extracting solution is obtained by filtering, and an aqueous solution, an ointment or a tincture is prepared. The Chinese medicinal preparation for treating the intractable leukoplakia vulvae of the female can be generally cured after continuously treating more than 6 treatment courses by taking half a month as a treatment course. The traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae has the effects of the ailanthus altissima bark, the paris polyphylla, the coptis chinensis and the cortex dictamni, can sterilize a patient to a certain extent, and can better cure the body of the patient to a certain extent.
Description
Technical Field
The invention relates to the technical field of medical supplies, in particular to a traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae.
Background
The leukoplakia vulvae is female vulvar dystrophy, is clinically divided into a hyperplastic type, a collapsed type and a mixed type, is an intractable disease occurring in women, has the female morbidity of about 1-5 percent and has a wide disease range. The clinical manifestations of hyperplastic leukoplakia vulvae are mainly as follows: local itching and pain are difficult to relieve, and after scratching, local ulceration leaves ulcer or chap. The hyperplastic local mucosa has leather-like change and coarse pigment degeneration. The atrophy of local tissues is mainly manifested by atrophy of the vaginal orifice or urethral orifice, which affects sexual life and dysuria in severe cases. At present, there are many methods for clinically treating leukoplakia vulvae, and oral medicines or external medicines are commonly used, and there are surgical excision method, laser treatment, and even leukoplakia vulvae therapeutic apparatus, but these methods are not ideal in curative effect, and patients suffer from pain for a long time.
Aiming at the prior art, the invention provides a traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women, in particular to a hyperplastic leukoplakia vulvae, the local application has the curative effect of immediately relieving itching, the local wound surface is healed (including scratches, cracks, ulcers, erosion, exudation and other wounds) and the hyperplasia is inhibited after the local application is continuously used for 5 days, most patients begin to generate pigmentation after the continuous application is continuously used for 15 days, the leukoplakia begins to be relieved, and the pain of the patients can be better relieved, so the traditional Chinese medicine penetrating preparation for treating the intractable leukoplakia vulvae is provided.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae, which has the advantages of better relieving the pain of patients and the like, and solves the problem that the pain of the patients cannot be relieved well.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: the traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae comprises the preparation method of 10-20 parts of cortex toonae sinensis, 10-20 parts of rhizoma paridis, 10-20 parts of coptis chinensis and 10-20 parts of cortex dictamni;
the preparation method comprises the following steps: taking the raw materials, carrying out ultrasonic extraction for 2-8 hours by using 50-95% ethanol (volume percentage) which is 10 times of the total weight of the raw materials, filtering to obtain an extracting solution, and preparing into a water agent, an ointment or a tincture;
when in treatment, the vulva is cleaned every day and then is smeared or cleaned on the affected part for 2-3 times, and the pruritus can be obviously added. The Chinese medicinal preparation for treating intractable leukoplakia vulvae can be generally cured after continuously treating more than 6 treatment courses by taking half a month as a treatment course, and has the total effective rate of 90.16 percent and the recurrence rate of 12.5 percent after 3 months of follow-up by applying to hundreds of patients in clinic.
Preferably, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 15 parts of ailanthus bark, 15 parts of paris polyphylla, 15 parts of coptis chinensis and 15 parts of cortex dictamni.
Preferably, the raw materials are taken, are subjected to ultrasonic extraction for 3-10 hours by using 50-95% ethanol in a volume percentage which is 10 times of the total weight of the raw materials, are filtered to obtain an extracting solution, and are prepared into a water agent, an ointment or a tincture.
Preferably, the method for preparing the water aqua is as follows: concentrating the extracting solution until the relative density is 1.32-1.34, wherein the relative density is measured at 50 ℃ to obtain the extract; the preparation method of the ointment comprises the following steps: concentrating the extracting solution until the relative density is 1.32-1.34, wherein the relative density is measured at 50 ℃, adding 1.5-2.5% of tragacanth by mass, and preparing into paste; the tincture preparation method comprises: adjusting the volume percentage of ethanol in the extracting solution to 10-30%.
Compared with the prior art, the invention provides the traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae, which has the following beneficial effects:
1. the traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae can perform certain effects of disinfection, detumescence, blood stasis removal and the like on a patient through the effects of the ailanthus bark, the seven-leaf and one-branch lotus, the coptis root and the cortex dictamni, can better cure the body of the patient to a certain extent, and achieves the effect of better curing the patient.
2. The traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae is prepared from Chinese medicinal materials such as ailanthus bark, paris polyphylla, coptis chinensis and cortex dictamni, so that when the traditional Chinese medicine osmotic preparation is used, side effects are reduced, harm to the body of a patient is reduced, and the effect of protecting the body of the patient is achieved.
Drawings
FIG. 1 is a flow chart of the preparation method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae comprises the preparation method of 10-20 parts of cortex toonae sinensis, 10-20 parts of rhizoma paridis, 10-20 parts of coptis chinensis and 10-20 parts of cortex dictamni;
the preparation method comprises the following steps: taking the raw materials, carrying out ultrasonic extraction for 2-8 hours by using 50-95% ethanol (volume percentage) which is 10 times of the total weight of the raw materials, filtering to obtain an extracting solution, and preparing into a water agent, an ointment or a tincture;
when in treatment, the vulva is cleaned every day and then is smeared or cleaned on the affected part for 2-3 times, and the pruritus can be obviously added. The Chinese medicinal preparation for treating intractable leukoplakia vulvae can be generally cured after continuously treating more than 6 treatment courses by taking half a month as a treatment course, and has the total effective rate of 90.16 percent and the recurrence rate of 12.5 percent after 3 months of follow-up by applying to hundreds of patients in clinic.
Example 1
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 150 g of paris polyphylla, 150 g of coptis root and 150 g of cortex dictamni, carrying out ultrasonic extraction for 5 hours by using 80 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, concentrating the extracting solution to the relative density of 1.22 (measured at 50 ℃), adding 1.5 percent of tragacanth, which is based on the mass of the concentrated solution, and preparing into paste.
Example 2
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 150 g of paris polyphylla, 150 g of coptis and 150 g of cortex dictamni, carrying out ultrasonic extraction for 8 hours by using 50 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, and concentrating the extracting solution until the relative density is 1.22-1.24 (measured at 50 ℃), thus obtaining the traditional Chinese medicine.
Example 3
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 150 g of paris polyphylla, 150 g of coptis and 150 g of cortex dictamni, carrying out ultrasonic extraction for 7 hours by using 60 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, and adjusting the ethanol content in the extracting solution to be 20 percent (volume percentage).
Example 4
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 150 g of paris polyphylla, 150 g of coptis root and 150 g of cortex dictamni, carrying out ultrasonic extraction for 2 hours by using 95 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, concentrating the extracting solution to the relative density of 1.24 (measured at 50 ℃), adding 1 percent of tragacanth by mass, and preparing into an ointment.
Example 5
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 150 g of paris polyphylla, 150 g of coptis root and 150 g of cortex dictamni, carrying out ultrasonic extraction for 8 hours by using 75 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, concentrating the extracting solution until the relative density is 1.24 (measured at 50 ℃), adding 2 percent of tragacanth by mass, and preparing into an ointment.
Example 6
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
100 g of ailanthus bark, 200 g of paris polyphylla, 100 g of coptis and 150 g of cortex dictamni are taken, ultrasonic extraction is carried out for 5 hours by using 80 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, an extracting solution is obtained by filtration, the extracting solution is concentrated to the relative density of 1.22 (measured at 50 ℃), and tragacanth, the mass of which is 1.5 percent of the mass of the concentrated solution, is added to prepare the ointment.
Example 7
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 200 g of ailanthus bark, 100 g of paris polyphylla, 200 g of coptis and 150 g of cortex dictamni, carrying out ultrasonic extraction for 4 hours by using 80 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, concentrating the extracting solution to the relative density of 1.22 (measured at 50 ℃), adding 1.5 percent of tragacanth in mass of the concentrated solution, and preparing into paste.
Example 8
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 120 g of paris polyphylla, 180 g of coptis and 150 g of cortex dictamni, carrying out ultrasonic extraction for 8 hours by using 80 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, concentrating the extracting solution to the relative density of 1.22 (measured at 50 ℃), adding 1.5 percent of tragacanth, which is based on the mass of the concentrated solution, and preparing into paste.
Example 9
Preparation of traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women
Taking 150 g of ailanthus bark, 120 g of paris polyphylla, 180 g of coptis and 150 g of cortex dictamni, carrying out ultrasonic extraction for 4 hours by using 85 percent ethanol (volume percentage) which is 10 times of the total weight of the medicinal materials, filtering to obtain an extracting solution, concentrating the extracting solution to the relative density of 1.22 (measured at 50 ℃), adding 1.5 percent of tragacanth, which is based on the mass of the concentrated solution, and preparing into paste.
Specifically, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 15 parts of ailanthus bark, 15 parts of paris polyphylla, 15 parts of coptis chinensis and 15 parts of cortex dictamni.
Specifically, the raw materials are taken, are subjected to ultrasonic extraction for 3-10 hours by using 50-95% ethanol in a volume percentage which is 10 times of the total weight of the raw materials, are filtered to obtain an extracting solution, and are prepared into a water agent, an ointment or a tincture.
Specifically, the method for preparing the water aqua comprises the following steps: concentrating the extracting solution until the relative density is 1.32-1.34, wherein the relative density is measured at 50 ℃ to obtain the extract; the preparation method of the ointment comprises the following steps: concentrating the extracting solution until the relative density is 1.32-1.34, wherein the relative density is measured at 50 ℃, adding 1.5-2.5% of tragacanth by mass, and preparing into paste; the tincture preparation method comprises: adjusting the volume percentage of ethanol in the extracting solution to 10-30%.
When in use, the external genitalia is cleaned every day and then is smeared or cleaned for 2-3 times during treatment, and the external genitalia pruritus can be obviously smeared. The disease can be cured after 1 month as one course of treatment and more than 3 courses of continuous treatment. The traditional Chinese medicine preparation for treating intractable leukoplakia vulvae of women has the total effective rate of 89.16% by applying to more than ten clinical patients, and the recurrence rate is 14.5% after 3 months of follow-up visit.
And (3) observation of curative effect:
1. treatment groups: in 200 cases of the group I (treatment group), test medicines (the medicines prepared in the embodiment 1) are adopted, the vulva is cleaned every day and then is smeared on an affected part for 2-3 times, and the pruritus can be obviously added. The treatment course is 1 month and 3 treatment courses are continued.
2. Control group: in group II (control group), 200 cases are treated with conventional 2% testosterone propionate ointment (Zhejiang Xianju pharmaceutical Co., Ltd., national drug standard H33021205), and the ointment is applied to the affected part 1-2 times after the vulva is cleaned every day. The treatment course is 1 month and 3 treatment courses are continued.
Evaluation criteria:
and (3) healing: the standard of no pruritus vulvae, repair of vulvar skin damage and improvement of skin color and elasticity is that no clinical symptoms or physical signs exist;
the effect is shown: the pruritus disappears or is obviously improved, the pathological skin is scattered and colored, and the elasticity of the skin basically returns to normal;
improvement: pruritus vulvae is relieved, chapped skin is improved, and skin color is changed;
and (4) invalidation: the signs of symptoms were unchanged from those before treatment.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. The traditional Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae comprises a preparation method and is characterized in that: 10-20 parts of ailanthus bark, 10-20 parts of paris polyphylla, 10-20 parts of coptis chinensis and 10-20 parts of cortex dictamni;
the preparation method comprises the following steps: taking the raw materials, carrying out ultrasonic extraction for 2-8 hours by using 50-95% ethanol (volume percentage) which is 10 times of the total weight of the raw materials, filtering to obtain an extracting solution, and preparing into a water agent, an ointment or a tincture;
when in treatment, the vulva is cleaned every day and then is smeared or cleaned on the affected part for 2-3 times, and the pruritus can be obviously added. The Chinese medicinal preparation for treating intractable leukoplakia vulvae can be generally cured after continuously treating more than 6 treatment courses by taking half a month as a treatment course, and has the total effective rate of 90.16 percent and the recurrence rate of 12.5 percent after 3 months of follow-up by applying to hundreds of patients in clinic.
2. The osmotic Chinese medicinal preparation for treating intractable leukoplakia vulvae according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15 parts of ailanthus bark, 15 parts of paris polyphylla, 15 parts of coptis chinensis and 15 parts of cortex dictamni.
3. The osmotic Chinese medicinal preparation for treating intractable leukoplakia vulvae according to claim 1, wherein: taking the raw materials, carrying out ultrasonic extraction on the raw materials for 3-10 hours by using 50-95% ethanol in a volume percentage which is 10 times of the total weight of the raw materials, filtering to obtain an extracting solution, and preparing into a water agent, an ointment or a tincture.
4. The osmotic Chinese medicinal preparation for treating intractable leukoplakia vulvae according to claim 1, wherein: the mode of preparing the water agent is as follows: concentrating the extracting solution until the relative density is 1.32-1.34, wherein the relative density is measured at 50 ℃ to obtain the extract; the preparation method of the ointment comprises the following steps: concentrating the extracting solution until the relative density is 1.32-1.34, wherein the relative density is measured at 50 ℃, adding 1.5-2.5% of tragacanth by mass, and preparing into paste; the tincture preparation method comprises: adjusting the volume percentage of ethanol in the extracting solution to 10-30%.
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| CN202110389074.9A CN112891449A (en) | 2021-04-12 | 2021-04-12 | Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae |
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| CN202110389074.9A CN112891449A (en) | 2021-04-12 | 2021-04-12 | Chinese medicine osmotic preparation for treating intractable leukoplakia vulvae |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552501A (en) * | 2011-12-29 | 2012-07-11 | 王爱华 | External traditional Chinese medicine composition for treating leukoplakia vulvae |
| CN104490959A (en) * | 2014-12-29 | 2015-04-08 | 江苏春申堂药业有限公司 | Traditional Chinese medicinal preparation for treating intractable leukoplakia vulvae of woman |
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2021
- 2021-04-12 CN CN202110389074.9A patent/CN112891449A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552501A (en) * | 2011-12-29 | 2012-07-11 | 王爱华 | External traditional Chinese medicine composition for treating leukoplakia vulvae |
| CN104490959A (en) * | 2014-12-29 | 2015-04-08 | 江苏春申堂药业有限公司 | Traditional Chinese medicinal preparation for treating intractable leukoplakia vulvae of woman |
Non-Patent Citations (1)
| Title |
|---|
| 黄小筠: "中药内外合用治疗外阴白斑120例", 《北京中医》 * |
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