CN112888447A - 减少菌群失调和恢复微生物群系的方法 - Google Patents

减少菌群失调和恢复微生物群系的方法 Download PDF

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Publication number
CN112888447A
CN112888447A CN201980068341.3A CN201980068341A CN112888447A CN 112888447 A CN112888447 A CN 112888447A CN 201980068341 A CN201980068341 A CN 201980068341A CN 112888447 A CN112888447 A CN 112888447A
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pharmaceutical composition
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clostridium
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J·诺曼
B·奥莱
B·罗伯茨
R·梅农
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Vedanta Biosciences Inc
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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    • C12Q2561/113—Real time assay
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10—Detection mode being characterised by the assay principle
    • C12Q2565/101—Interaction between at least two labels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201980068341.3A 2018-08-17 2019-08-16 减少菌群失调和恢复微生物群系的方法 Pending CN112888447A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862765165P 2018-08-17 2018-08-17
US62/765,165 2018-08-17
US201862724185P 2018-08-29 2018-08-29
US62/724,185 2018-08-29
US201962815395P 2019-03-08 2019-03-08
US62/815,395 2019-03-08
US201962829513P 2019-04-04 2019-04-04
US62/829,513 2019-04-04
US201962829959P 2019-04-05 2019-04-05
US62/829,959 2019-04-05
PCT/US2019/046926 WO2020037271A1 (en) 2018-08-17 2019-08-16 Methods of decreasing dysbiosis and restoring a microbiome

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CN112888447A true CN112888447A (zh) 2021-06-01

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KR (1) KR20210091119A (enExample)
CN (1) CN112888447A (enExample)
AU (1) AU2019321681A1 (enExample)
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Cited By (2)

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CN113486954A (zh) * 2021-07-06 2021-10-08 广西爱生生命科技有限公司 一种肠道微生态差异菌分类处理方法及肠道健康评估方法
CN114496279A (zh) * 2022-01-12 2022-05-13 广州保量医疗科技有限公司 菌群移植配型的排序方法、系统、计算机设备及存储介质

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KR102503766B1 (ko) * 2020-06-16 2023-02-23 씨제이바이오사이언스 주식회사 장내 마이크로바이옴 지수를 결정하기 위한 장치, 방법 및 명령을 기록한 기록 매체
CN111796043B (zh) * 2020-08-15 2022-02-22 山东北大高科华泰制药有限公司 注射用盐酸罂粟碱粉针剂及其质量检测方法
WO2022159711A1 (en) 2021-01-21 2022-07-28 Vedanta Biosciences, Inc. Compositions and methods for treating hepatic encephalopathy
WO2023278477A1 (en) * 2021-06-28 2023-01-05 Vedanta Biosciences, Inc. Methods of colonizing a microbiome, treating and/or preventing inflammatory bowel disease and graft versus host disease
WO2024218184A1 (en) * 2023-04-20 2024-10-24 Ecole Polytechnique Federale De Lausanne (Epfl) AN ANTIBIOTIC AND A MICROORGANISM HAVING BILE ACID 7α-DEHYDROXYLATION ACTIVITY FOR TREATING NON-INFECTIOUS DISEASES
WO2024227021A2 (en) * 2023-04-28 2024-10-31 Vedanta Biosciences, Inc. Compositions and methods for treating clostridioides difficile infection
WO2025076184A1 (en) 2023-10-03 2025-04-10 Vedanta Biosciences, Inc. Methods of decreasing dysbiosis and restoring a microbiome
WO2025093778A1 (en) * 2023-11-05 2025-05-08 Human Biome Institute S.A. Functional compositions and methods of use thereof in eradication and/or decolonization of antibiotic-resistant bacteria and restoration of healthy microbiota

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN113486954A (zh) * 2021-07-06 2021-10-08 广西爱生生命科技有限公司 一种肠道微生态差异菌分类处理方法及肠道健康评估方法
CN114496279A (zh) * 2022-01-12 2022-05-13 广州保量医疗科技有限公司 菌群移植配型的排序方法、系统、计算机设备及存储介质

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EP3836946A4 (en) 2022-05-04
JP2024119856A (ja) 2024-09-03
JP2022500489A (ja) 2022-01-04
AU2019321681A1 (en) 2021-02-25
US20250161375A1 (en) 2025-05-22
US20220143108A1 (en) 2022-05-12
JP7558170B2 (ja) 2024-09-30
IL280779A (en) 2021-04-29
IL280779B2 (en) 2025-05-01
KR20210091119A (ko) 2021-07-21
IL317775A (en) 2025-02-01
WO2020037271A1 (en) 2020-02-20
IL280779B1 (en) 2025-01-01
US12161680B2 (en) 2024-12-10

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