CN112871885B - Cleaning device for sample adding needle, cleaning liquid path system and method thereof, and sample analyzer - Google Patents
Cleaning device for sample adding needle, cleaning liquid path system and method thereof, and sample analyzer Download PDFInfo
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- CN112871885B CN112871885B CN201911206556.5A CN201911206556A CN112871885B CN 112871885 B CN112871885 B CN 112871885B CN 201911206556 A CN201911206556 A CN 201911206556A CN 112871885 B CN112871885 B CN 112871885B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/023—Cleaning the external surface
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
- B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
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Abstract
The invention discloses a cleaning device of a sampling needle, a cleaning liquid path system, a method and a sample analyzer thereof, wherein the cleaning liquid path system comprises a cleaning pool, a cleaning liquid providing device, a waste liquid absorbing device and at least one liquid flow control valve, the cleaning pool is used for storing the cleaning liquid, the cleaning pool is provided with a cleaning port which enables the cleaning liquid to shoot to the sampling needle, and the liquid flow control valve is arranged on a pipeline from the cleaning liquid providing device to the cleaning pool and/or from the cleaning liquid providing device to the sampling needle and can be controllably switched between opening and closing. Because wash the pond and have the washing mouth that makes the washing liquid directive to the application of sample needle for after placing the application of sample needle and wash the pond, can improve the cleaning performance to the application of sample needle, can change the order and the cleaning time of wasing inner wall, the outer wall to the application of sample needle through rationally selecting the liquid flow control valve simultaneously, can effectively promote cleaning efficiency.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a cleaning device of a sample adding needle, a cleaning liquid path system and method thereof and a sample analyzer.
Background
In clinical examination equipment, a sample or a reagent is generally transferred by using a sample adding needle, for example, the reagent needle firstly sucks the reagent in a reagent bottle and then discharges the reagent in a reaction cup when in work, and then the inner wall and the outer wall of the reagent needle are cleaned and the next cycle of work is carried out.
In an automatic sample analyzer, tests of various items are usually performed, one reagent needle is often required to be switched among different reagents, the viscosity of the reagents is generally high and is easily adhered to the outer wall of the reagent needle, certain difficulty is caused in cleaning of the reagent needle, the reagent needle is generally cleaned by penetrating the reagent needle into a cleaning solution with a cleaning effect, the cleaning time is long, the cleaning effect is difficult to guarantee, pollution is easily formed between the reagents, and the prior art cannot be well solved.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a cleaning device of a sample adding needle, a cleaning liquid path system and a cleaning method thereof and a sample analyzer, which can realize the purpose of effectively cleaning the sample adding needle.
According to a first aspect, an embodiment provides a cleaning solution path system for a sample injection needle, comprising:
the cleaning pool is used for storing cleaning liquid and is provided with a cleaning port which enables the cleaning liquid to shoot to the sampling needle;
the pipeline of the cleaning liquid supply device is communicated with the cleaning pool and the sampling needle and is used for supplying cleaning liquid to the cleaning pool and/or the sampling needle;
the pipeline of the waste liquid absorption device is communicated to the cleaning pool and used for recovering the waste liquid flowing out of the cleaning pool;
and at least one liquid flow control valve, which is arranged on a pipeline between the cleaning liquid supply device and the cleaning pool and/or between the cleaning liquid supply device and the sample adding needle and can be controllably switched between opening and closing.
According to a second aspect, an embodiment provides a cleaning device for a sample injection needle, including a cleaning solution path system and a controller, the cleaning solution path system is configured to provide a cleaning solution and recover waste liquid generated by cleaning, and the cleaning solution path system includes:
the cleaning pool is used for storing cleaning liquid and is provided with a cleaning port which enables the cleaning liquid to shoot to the sampling needle;
the pipeline of the cleaning liquid supply device is communicated with the cleaning pool and the sample adding needle and is used for supplying cleaning liquid to the cleaning pool and/or the sample adding needle;
the pipeline of the waste liquid absorption device is communicated to the cleaning pool and used for recovering the waste liquid flowing out of the cleaning pool;
and at least one liquid flow control valve, which is arranged on a pipeline between the cleaning liquid supply device and the cleaning pool and/or between the cleaning liquid supply device and the sample adding needle and can be controllably switched between opening and closing;
the controller is respectively in signal connection with the sample adding needle and the liquid flow control valve and is used for controlling the sample adding needle to enter the cleaning pool according to a preset first speed, controlling the sample adding needle to leave the cleaning pool according to a preset second speed and controlling the liquid flow control valve to be opened or closed according to a set time sequence.
According to a third aspect, an embodiment provides a method for cleaning a sample addition needle, the method comprising: and controlling the sample adding needle to enter the cleaning pool according to a preset first speed, controlling the sample adding needle to leave the cleaning pool according to a preset second speed, and controlling the liquid flow control valve to be opened or closed according to a set time sequence.
According to a fourth aspect, there is provided in an embodiment a sample analyzer comprising a wash liquid circuit according to the first aspect of the invention.
According to a fifth aspect, an embodiment provides a sample analyzer comprising a cleaning device according to the second aspect of the invention.
The embodiment of the invention has the following beneficial effects:
according to the cleaning solution path system and the cleaning device of the sampling needle and the sample analyzer in the above embodiments, since the cleaning tank has the cleaning port for ejecting the cleaning solution to the sampling needle, after the sampling needle is placed in the cleaning tank, the cleaning effect on the sampling needle can be improved, and meanwhile, the cleaning sequence and the cleaning time for cleaning the inner wall and the outer wall of the sampling needle can be changed by reasonably selecting the liquid flow control valve, so that the cleaning efficiency can be effectively improved.
According to the method for cleaning the sample adding needle in the embodiment, the sequence and the cleaning time for cleaning the inner wall and the outer wall of the sample adding needle can be changed by reasonably selecting the liquid flow control valve, and meanwhile, the speed for the sample adding needle to enter the cleaning pool or leave the cleaning pool is matched, so that the cleaning effect and the cleaning efficiency can be effectively improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Wherein:
FIG. 1 illustrates a schematic diagram of a cleaning fluid path system provided in accordance with an embodiment of the present invention;
FIG. 2 is a schematic view showing a structure of a cleaning tank according to an embodiment of the present invention;
FIG. 3 is a schematic view showing the structure of another cleaning tank provided according to the embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a first tank body of another cleaning tank provided in an embodiment of the invention;
fig. 5 shows a schematic structural diagram of a second tank body of another cleaning tank provided in an embodiment of the invention.
Description of the main element symbols:
100-a cleaning pool; 200-a cleaning solution supply device; 300-a waste liquid absorption device; 400-a liquid flow control valve; 101-a cleaning port; 102-a reservoir chamber; 103-a liquid inlet channel; 104-a waste liquid absorption chamber; 105-a waste liquid absorption channel; 106-a cleaning solution temporary storage cavity; 110-a peripheral frame; 120-inner frame body; 130-liquid inlet frame body; 140-a waste liquid frame; 150-a first cell body; 160-a second tank body; 210-a cleaning solution supply reservoir; 220-first liquid pump; 230-three-way diverter valve; 310-a waste liquid absorption tank; 320-a second liquid pump; 410-a first flow control valve; 420-a second flow control valve; 151-first liquid inlet channel; 161-a second liquid inlet channel; 1000-sample application needle.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In an embodiment of the present invention, a cleaning device for a sample application needle (hereinafter, referred to as "cleaning device") is provided, and the cleaning device can be applied to a sample analyzer, such as a blood coagulation analyzer, an immunoassay analyzer, and the like, and is used for cleaning a sample application needle, such as a reagent needle, a sample needle, and the like.
In particular, for a blood coagulation analyzer, certain test items need to ensure that the reagent has sufficiently stable performance and does not allow the reagent to be mixed with other reagents, for example, when the blood coagulation analyzer performs functional analysis such as blood coagulation and blood coagulation on a blood sample, a coagulant is needed in the analysis process, the anti-contamination requirement of the coagulant is high, especially for TT or FIB detection reagents, thrombin is the main component of the reagent, and if reagent needles of residual reagents contaminate other detection reagents (such as PT or APTT), the test result is affected.
This belt cleaning device includes cleaning solution way system and controller, and cleaning solution way system is used for providing the washing liquid and retrieves and washs produced waste liquid, and the controller then is used for controlling cleaning solution way system's liquid stream flow direction, liquid stream collocation and the motion of application of sample needle, can improve the cleaning performance to the application of sample needle to can effectively promote the cleaning efficiency.
In an embodiment of the present invention, referring to fig. 1, the cleaning solution path system includes a cleaning tank 100, a cleaning solution providing device 200, a waste liquid absorbing device 300, and at least one liquid flow control valve 400.
The washing pool 100 is used for storing a washing solution, which may be selected according to a sample or a reagent to be washed, for example, the washing solution may be an enzyme washing solution, clear water, or a special washing solution for some detection items. The cleaning cell 100 has a cleaning port 101 for directing a cleaning liquid to the sampling needle 1000.
The pipeline of the cleaning solution providing device 200 is communicated with the cleaning pool 100 and the sampling needle 1000, and is used for providing cleaning solution to the cleaning pool 100 and/or the sampling needle 1000.
It can be understood that the cleaning solution provided by the cleaning solution providing device 200 to the cleaning pool 100 is mainly used for cleaning the outer wall of the sampling needle 1000, the cleaning solution provided by the cleaning solution providing device 200 to the sampling needle 1000 is mainly used for cleaning the inner wall of the sampling needle 1000, and if both cleaning operations are involved, the complete cleaning of the sampling needle 1000 can be realized, and the embodiment herein is mainly described in such a case.
The piping of the waste liquid absorbing apparatus 300 communicates to the washing tank 100 for recovering the waste liquid flowing out from the washing tank 100.
The liquid flow control valve 400 is provided in a piping between the cleaning liquid supplying means 200 to the cleaning reservoir 100 and/or the cleaning liquid supplying means 200 to the sampling needle 1000, and is controllably switched between an open state and a closed state.
The cleaning solution supply device 200 can selectively deliver the cleaning solution to the cleaning reservoir 100 and the sampling needle 1000 or to both the cleaning reservoir 100 and the sampling needle 1000 by the arrangement of the liquid flow control valve 400.
In the cleaning solution path system of the embodiment of the invention, the cleaning tank 100 is provided with the cleaning port 101 which enables the cleaning solution to be emitted to the sampling needle 1000, so that after the sampling needle 1000 is placed in the cleaning tank 100, the cleaning effect on the sampling needle 1000 can be improved, and meanwhile, the sequence and the cleaning time for cleaning the inner wall and the outer wall of the sampling needle 1000 can be changed by reasonably selecting the liquid flow control valve 400, and the cleaning efficiency can be effectively improved.
In the case where the cleaning liquid supply device 200 supplies the cleaning liquid to the cleaning reservoir 100 and the sampling needle 1000, and the liquid flow control valves 400 are disposed in the channels from the cleaning liquid supply device 200 to the cleaning reservoir 100 and from the cleaning liquid supply device 200 to the sampling needle 1000, it can be known that the cleaning liquid channel system is provided with two liquid flow control valves 400. In addition, it should be noted that only the sample injection needle 1000 is described as being located in the washing chamber 100, and the following related contents can be referred to for other cooperation relationships between the sample injection needle 1000 and the flow control valve 400.
For the liquid flow control valve 400, it can be known that the time for cleaning the inner wall or the outer wall of the sampling needle 1000 can be adjusted by controlling the opening and closing time nodes thereof, and the sequence for cleaning the inner wall and the outer wall of the sampling needle 1000 can be adjusted by controlling the opening and closing sequence of the liquid flow control valve 400.
In some embodiments, the liquid flow control valve 400 in the pipe between the cleaning solution providing device 200 and the cleaning reservoir 100 may be opened first, and after a certain period of time, the liquid flow control valve 400 in the pipe between the cleaning solution providing device 200 and the sample injection needle 1000 may be opened, so that the outer wall of the sample injection needle 1000 may be cleaned first, and then the inner wall of the sample injection needle 1000 may be cleaned.
In other embodiments, the liquid flow control valve 400 in the pipe between the cleaning solution providing device 200 and the sample injection needle 1000 may be opened first, and after a certain period of time, the liquid flow control valve 400 in the pipe between the cleaning solution providing device 200 and the cleaning tank 100 may be opened, so that the inner wall of the sample injection needle 1000 may be cleaned first, and the outer wall of the sample injection needle 1000 may be cleaned, and when the outer wall is cleaned, the cleaning solution may be directed toward the sample injection needle 1000, which may improve the cleaning effect.
In some preferred embodiments, the liquid flow control valve 400 in the pipeline between the cleaning liquid providing device 200 and the cleaning pool 100 and in the pipeline between the cleaning liquid providing device 200 and the sample injection needle 1000 can be opened at the same time, so that the inner wall and the outer wall of the sample injection needle 1000 can be cleaned at the same time, which not only can improve the cleaning effect, but also can effectively improve the cleaning efficiency.
Taking the case that the liquid flow control valve 400 is disposed in one of the pipelines from the cleaning liquid providing device 200 to the cleaning reservoir 100 and from the cleaning liquid providing device 200 to the sampling needle 1000, for example, the liquid flow control valve 400 is disposed between the cleaning liquid providing device 200 and the cleaning reservoir 100, it can be known that by controlling the time node of opening and closing of the liquid flow control valve 400, the time node and the cleaning time of the liquid flow control valve can be controlled, and the purposes of improving the cleaning effect and effectively improving the cleaning efficiency can be achieved.
In some embodiments, the flow control valve 400 may be a two-position, two-way solenoid valve, which is capable of receiving a control signal from a controller and controllably switching between open and closed states.
In an embodiment of the present invention, referring to fig. 1, the cleaning solution supply device 200 includes a cleaning solution supply reservoir 210 and at least one first liquid pump 220, the first liquid pump 220 is disposed on a pipeline between the cleaning solution supply reservoir 210 to the cleaning reservoir 100 and/or between the cleaning solution supply reservoir 210 to the needle 1000, and the liquid flow control valve 400 is disposed on a pipeline between the first liquid pump 220 to the cleaning reservoir 100 and/or between the first liquid pump 220 to the needle 1000.
The first liquid pump 220 is used for generating power, so that the cleaning liquid in the cleaning liquid supply reservoir 210 can be delivered to the cleaning reservoir 100 and/or the sampling needle 1000, and the cleaning liquid can be delivered to the cleaning reservoir 100 and the sampling needle 1000 or delivered to the cleaning reservoir 100 and the sampling needle 1000 simultaneously by combining with the opening and closing of the liquid flow control valve 400.
In some embodiments, the first liquid pumps 220 may be provided in two, and two first liquid pumps 220 are connected to the cleaning solution supply reservoir 210, and a liquid path channel is formed between the cleaning solution supply reservoir 210 and the cleaning solution supply reservoir 100 and between the cleaning solution supply reservoir 210 and the sampling needle 1000, and a liquid flow control valve 400 may be provided on each liquid path channel, and the delivery of the cleaning solution is realized by controlling the opening and closing of the liquid flow control valve 400.
In some preferred embodiments, there are one first liquid pump 220, two liquid flow control valves 400, one end of the first liquid pump 220 is connected to the cleaning solution supply reservoir 210, the other end is connected to the cleaning reservoir 100 and the sampling needle 1000, the two liquid flow control valves 400 are a first liquid flow control valve 410 disposed between the first liquid pump 220 and the cleaning reservoir 100 and a second liquid flow control valve 420 disposed between the first liquid pump 220 and the sampling needle 1000, respectively, the cleaning solution supply apparatus 200 further includes a three-way flow dividing valve 230, and the three-way flow dividing valve 230 is disposed on a cross pipeline from the first liquid pump 220 to the cleaning reservoir 100 and the sampling needle 1000.
At this time, it can be understood that the two liquid path channels share one first liquid pump 220, and the cleaning cell 100 and the sample injection needle 1000 share one first liquid pump 220, so that the cost of the cleaning liquid path system and the complexity of the structure of the cleaning liquid path system can be significantly reduced.
Meanwhile, by adopting the above arrangement, a section of common channel can be generated on the two liquid channels, and the common channel can be realized by a section of cross pipeline, for example, the cross pipeline can be communicated between the cleaning liquid supply reservoir 210 and the three-way diverter valve 230, and the first liquid pump 220 is positioned on the cross pipeline, so that the cleaning liquid output from the cleaning liquid supply reservoir 210 can be divided into two parts at the three-way diverter valve 230, and at this time, the cleaning liquid can be selectively conveyed to the cleaning reservoir 100 and the sampling needle 1000 by combining the two liquid flow control valves 400, or the cleaning liquid can be conveyed to the cleaning reservoir 100 and the sampling needle 1000 at the same time.
It should be noted that, the above description is only a practical matching manner of the first liquid pump 220 and the liquid flow control valve 400, and it can be understood that, on the basis of the above matching manner, the number, the front-back order, and the like of the first liquid pump 220 and the liquid flow control valve 400 can be easily replaced or moved, as long as it can help the cleaning liquid providing device 200 to selectively deliver the cleaning liquid to the cleaning pool 100 and the sample adding needle 1000, or to both the cleaning pool 100 and the sample adding needle 1000, without affecting the embodiment of the technical solution of the present invention, in other words, any replacement or movement is protected by the present invention.
In the embodiment of the present invention, referring to fig. 1, the waste liquid absorption apparatus 300 includes a waste liquid absorption tank 310 and a second pump 320, wherein the second pump 320 is disposed on a pipeline from the cleaning tank 100 to the waste liquid absorption tank 310.
Thus, the waste liquid in the cleaning tank 100 can be discharged into the waste liquid absorption tank 310 by the second liquid pump 320, and the sample addition needle 1000 can be prevented from being secondarily contaminated by the waste liquid.
Further, some devices or materials capable of decomposing, diluting or absorbing the waste liquid may be added to the waste liquid absorption tank 310, for example, a proper amount of honeycomb briquette may be prevented from being placed at the bottom of the waste liquid absorption tank 310, or some decomposing agent may be added to the waste liquid absorption tank 310.
In the embodiment of the present invention, referring to fig. 2 to 5, the cleaning tank 100 includes a liquid storage cavity 102 and a liquid inlet channel 103, one end of the liquid inlet channel 103 is connected to the cleaning liquid providing device 200, the other end is connected to the liquid storage cavity 102, and a cleaning opening 101 is formed at the cavity wall of the liquid storage cavity 102.
Therefore, the cleaning liquid for cleaning the sampling needle 1000 can be stored in the liquid storage cavity 102, and the liquid inlet channel 103 can establish a communication relation between the liquid storage cavity 102 and the cleaning liquid providing device 200, so that the cleaning liquid can be conveyed to the liquid storage cavity 102 from the cleaning liquid providing device 200.
In one embodiment, referring to fig. 2, the cleaning tank 100 includes an outer frame 110, an inner frame 120, and a liquid inlet frame 130, the outer frame 110 is disposed at the periphery of the inner frame 120 and encloses with the inner frame 120 to form a waste liquid absorption chamber 104, the inner frame 120 encloses to form a liquid storage chamber 102, the liquid inlet frame 130 extends from the outer frame 110 to the inner frame 120 and communicates with the liquid storage chamber 102, and the liquid inlet frame 130 forms a liquid inlet channel 103.
This washing pond 100 can form stock solution chamber 102 and waste liquid absorption chamber 104 that separate each other to stock solution chamber 102 is in the periphery of waste liquid absorption chamber 104, and liquid inlet frame 130 extends to interior frame 120, thereby not only makes washing pond 100 have the function of holding the washing liquid and discharging the waste liquid, still can make whole washing pond 100 have compact structural characteristic.
In a specific embodiment, the outer frame 110, the inner frame 120 and the liquid inlet frame 130 are all designed to be cylindrical, at this time, the outer frame 110 and the inner frame 120 can be coaxially disposed, and the liquid inlet frame 130 is disposed at a position near the bottom of the outer frame 110 or the inner frame 120, at this time, when the liquid storage cavity 102 is filled with the cleaning liquid, and the sampling needle 1000 penetrates the bottom of the liquid storage cavity 102 and faces the cleaning opening 101, the cleaning liquid flowing out from the cleaning opening 101 will flush the sampling needle 1000 at a maximum flow rate, and at this time, the high pressure characteristic at the deeper position is combined, so that the cleaning effect on the sampling needle 1000 can be significantly improved.
Of course, in other embodiments, the peripheral frame 110, the inner frame 120 and the liquid inlet frame 130 may be configured in other shapes or configurations, such as a square cross section.
One or more liquid inlet frames 130 may be provided, and when there are a plurality of liquid inlet frames 130, the liquid inlet frames 130 are provided at uniform intervals.
A plurality of feed liquor framework 130 can form a plurality of washing mouths 101, not only can realize rinsing the sample injection needle 1000's multi-angle, can also increase the scouring force degree, effectively improves the cleaning performance.
Further, the liquid inlet frame bodies 130 are preferably located on the same plane, so that the cleaning ports 101 formed by the liquid inlet frame bodies 130 can be converged into a point at the position where the sample adding needle 1000 is located, and the cleaning effect on the sample adding needle 1000 can be further improved.
In some specific examples, the inner frame body 120 is recessed within the outer frame body 110 such that the top surface of the outer frame body 110 is higher than the top surface of the inner frame body 120.
The advantage of this design is that when the cleaning liquid in the reservoir 102 overflows the reservoir 102, the overflowing cleaning liquid (a part of the waste liquid) can enter the waste liquid absorption chamber 104 to be discharged smoothly. Meanwhile, the height of the liquid storage cavity 102 can be fully utilized by the inward-sinking design, so that the height of the liquid storage cavity 102 is utilized to the maximum extent, the maximum pressure is formed, the cleaning effect of the sample adding needle 1000 is improved, and meanwhile, the cleaning liquid does not need to be sprayed out.
In addition, for better discharging of the waste liquid, a plurality of liquid discharge ports (not shown) may be formed in the bottom of the inner frame 120, so that the waste liquid can be more quickly and smoothly discharged into the waste liquid absorption chamber 104. It is understood that the drain port should be disposed away from the cleaning port 101.
In some embodiments, the cleaning tank 100 further includes a waste frame 140, the waste frame 140 is connected between the outer frame 110 and the inner frame 120, and forms a waste absorption channel 105 together with the outer frame 110 and the inner frame 120, and the waste absorption channel 105 is communicated with the waste absorption chamber 104.
Through the setting of this waste liquid framework 140, can carry out extension to a certain extent to the peripheral structure of wasing pond 100, compare in the mode that directly adopts waste liquid absorption room 104 to arrange the waste liquid, the existence of this waste liquid framework 140 can realize more easily wasing pond 100 and waste liquid absorbing device 300, and even the relation of connection of other equipment, for example with the equipment that carries out the aftertreatment to the waste liquid is connected, this aftertreatment equipment, for example can be sewage treatment pond etc..
In another embodiment, referring to fig. 3-5, the cleaning tank 100 includes a first tank 150 and a second tank 160, the first tank 150 is formed with a liquid storage cavity 102 and a first liquid inlet channel 151 communicated with the liquid storage cavity 102, the second tank 160 is disposed at the periphery of the first tank 150, the second tank 160 is formed with a second liquid inlet channel 161, and the second liquid inlet channel 161 is communicated with the first liquid inlet channel 151 to form the liquid inlet channel 103.
In a specific embodiment, the first tank 150 and the second tank 160 are both designed to be cylindrical, and at this time, the first tank 150 and the second tank 160 can be coaxially disposed, and the first liquid inlet channel 151 of the first tank 150 and the second liquid inlet channel 161 of the second tank 160 are located at respective bottoms, so that when the liquid storage chamber 102 is filled with the cleaning liquid, and the sample injection needle 1000 extends into the bottom of the liquid storage chamber 102 and faces the cleaning port 101, the cleaning liquid flowing out of the cleaning port 101 can be flushed onto the sample injection needle 1000 at the maximum flow rate, and at this time, the cleaning effect on the sample injection needle 1000 can be obviously improved by combining the characteristic of high pressure at the deeper position.
Of course, in other specific embodiments, the first and second cell bodies 150 and 160 may also be configured in other shapes or configurations, such as having a square cross-section, etc.
It should be noted that, one or more first liquid inlet channels 151 and one or more second liquid inlet channels 161 may be provided, and when there are a plurality of first liquid inlet channels 151 and a plurality of second liquid inlet channels 161, the first liquid inlet channels 151 and the second liquid inlet channels 161 are uniformly spaced.
A plurality of washing mouths 101 can be formed in the setting of a plurality of first inlet channels 151 and second inlet channel 161, not only can realize rinsing the multi-angle of application of sample needle 1000, can also increase the scouring force degree, effectively improves the cleaning performance.
Further, a plurality of cleaning ports 101 formed by the first inlet channel 151 and the second inlet channel 161 are preferably located on the same plane, so that the plurality of cleaning ports 101 can be converged into a point at the position of the sampling needle 1000, and the cleaning effect on the sampling needle 1000 can be further improved.
In some embodiments, please refer to fig. 3-4, the outer wall of the first tank 150 is recessed to form a recessed area, the first liquid inlet channel 151 extends into the liquid storage chamber 102 from the recessed area, the second tank 160 is disposed around the first tank 150 in a sealing manner, the second liquid inlet channel 161 extends into the recessed area from the second tank 160, and the inner wall of the second tank 160 and the recessed area enclose to form the temporary cleaning liquid storage chamber 106.
This embodiment is because the setting of washing liquid chamber 106 of keeping in, make the washing liquid that carries from second inlet channel 161 gather at the washing liquid chamber 106 of keeping in at first, after assembling to a certain extent, keep in chamber 106 again from this washing liquid and spout from washing mouth 101 finally through second inlet channel 161, in this process, washing liquid chamber 106 of keeping in is equivalent to once assembling the washing liquid, its stock solution ability is superior to first inlet channel 151 undoubtedly, consequently, can improve the velocity of flow of washing liquid to a certain extent, make it spout from washing mouth 101 fast, be favorable to improving the cleaning performance.
It is understood that the cleaning solution temporary storage chamber 106 can be designed to be communicated or separated according to the number of the first inlet channels 151 and the second inlet channels 161.
For example, when the first liquid inlet channel 151 and the second liquid inlet channel 161 are both provided in plural numbers, referring to fig. 4, all of the first liquid inlet channel 151 and the second liquid inlet channel 161 may be communicated with a single cleaning liquid temporary storage cavity 106 designed in a communication manner, and at this time, the cleaning liquid temporary storage cavity 106 is formed by integrally recessing the outer wall of the first tank 150. Of course, the first liquid inlet channel 151 and the second liquid inlet channel 161 may also be in one-to-one matching communication with a plurality of cleaning liquid temporary storage cavities 106 designed at intervals, and at this time, the cleaning liquid temporary storage cavities 106 are formed by interval-type depression of the outer wall of the first tank body 150, that is, some parts of the outer wall of the first tank body 150 are depressed.
Further, the inner diameter of the second liquid inlet channel 161 is larger than the inner diameter of the first liquid inlet channel 151, so that the flow speed of the cleaning liquid flowing out from the cleaning opening 101 can be increased, and the cleaning effect can be improved.
In addition, in order to increase the flow rate, the inner diameter of the second inlet channel 161 may be set to be gradually smaller from the outside to the inside, and the inner diameter of the first inlet channel 151 may be set to be gradually smaller from the outside to the inside.
Further, the axis of the second inlet channel 161 is located at a lower position than the axis of the first inlet channel 151.
The advantage of this arrangement is that the space of the cleaning liquid temporary storage chamber 106 can be fully utilized, so that the cleaning liquid can fill the whole cleaning liquid temporary storage chamber 106 first and then flow into the liquid storage chamber 102, thereby fully exerting the aforementioned "converging" effect of the cleaning liquid temporary storage chamber 106.
On the other hand, in the embodiment that the cleaning solution temporary storage cavity 106 is designed to be communicated, after the cleaning solution temporary storage cavity 106 is filled with the cleaning solution, the cleaning solution can flow out from the first liquid inlet channel 151 synchronously, so that the force balance of the cleaning solution applied to the sample adding needle 1000 can be improved, and the improvement of the cleaning effect is facilitated.
In some specific embodiments, the first tank 150 further forms a waste fluid absorption channel 105 in communication with the reservoir 102, and the waste fluid absorption channel 105 has an inner diameter smaller than that of the reservoir 102.
This waste liquid absorption passageway 105 can communicate with waste liquid absorbing device 300 to discharge the waste liquid in the washing pond 100 into in waste liquid absorbing device 300, the internal diameter setting of this waste liquid absorption passageway 105 can effectively control waste liquid exhaust speed simultaneously, prevents to appear the circumstances that the displacement is greater than the feed liquor volume.
In the embodiment of the present invention, the controller is respectively in signal connection with the sampling needle 1000 and the liquid flow control valve 400, and is configured to control the sampling needle 1000 to enter the cleaning cell 100 according to a predetermined first speed, control the sampling needle 1000 to leave the cleaning cell 100 according to a predetermined second speed, and control the liquid flow control valve 400 to open or close according to a set timing sequence.
Through the control of controller to application of sample needle 1000 and liquid flow control valve 400, can rationally change the order and the cleaning time of wasing inner wall, the outer wall to application of sample needle 1000, collocation application of sample needle 1000 enters into and washs pond 100 or leaves the speed that washs pond 100 simultaneously, can effectively promote cleaning efficiency.
Taking the aforementioned arrangement of two liquid flow control valves 400 as an example, the aforementioned method may specifically be:
s10, controlling the first liquid flow control valve 410 to be opened;
s20, controlling the sample adding needle 1000 to enter the cleaning pool 100 at a first speed;
s30, controlling the second liquid flow control valve 420 to be opened or controlling the second liquid flow control valve 420 to be opened and simultaneously controlling the first liquid flow control valve 410 to be closed;
s40, controlling the second flow control valve 420 to close;
s50, controlling the sample adding needle 1000 to leave the cleaning pool 100 at a second speed.
In the above method, the first speed is greater than the second speed, thereby improving the cleaning efficiency and preventing the liquid hanging phenomenon.
Specifically, the foregoing steps S10 and S20 are used to clean the outer wall of the sampling needle 1000, and the first speed is preferably fast, so that in the process of entering the sampling needle 1000 into the cleaning pool 100, the outer wall of the sampling needle is sufficient to form sufficient resistance with the cleaning solution, which is beneficial to separating the reagent adhered to the outer wall of the sampling needle 1000, thereby improving the cleaning efficiency.
The aforementioned step S30 is for cleaning the inner wall of the sampling needle 1000, and the cleaning process is preferably performed after the step S20, so as to conveniently and better recycle the waste liquid. Meanwhile, the cleaning process may be performed simultaneously with the above-described cleaning process of the outer wall by changing the opening or closing of the first and second flow control valves 410 and 420, or may be performed after the cleaning process of the outer wall is completely finished.
The aforementioned steps S40 and S50 are for preventing the liquid hanging phenomenon, and when the inner wall is cleaned, the second flow control valve 420 is closed, and the second speed is preferably slow, so that the sample injection needle 1000 can slowly leave the cleaning pool 100, thereby preventing the cleaning liquid from being adhered to the outer wall of the sample injection needle 1000.
In a specific embodiment, the opening of the first liquid flow control valve 410 and the introduction of the sample injection needle 1000 into the washing tank 100 are controlled simultaneously or sequentially at a first speed, so that the washing time can be substantially saved, thereby improving the washing efficiency.
In another specific embodiment, the controlling the sample injection needle 1000 to enter the washing pool 100 at the first speed is performed after controlling the first flow control valve 410 to open, and after controlling the first flow control valve 410 to open, the method further includes: the cleaning liquid is formed to have a certain liquid level in the cleaning tank 100.
Before the sample adding needle 1000 enters the cleaning pool 100, the cleaning pool 100 is already provided with cleaning liquid with a certain liquid level height, the cleaning liquid has certain fluidity, and at the moment, when the sample adding needle 1000 rapidly enters the cleaning pool 100 at the first speed, the acting force of the cleaning liquid on the sample adding needle 1000 can be effectively increased, so that the cleaning effect is improved.
It should be noted that the liquid level can be selected according to the actual cleaning requirement, and generally, the liquid level is preferably flush with the top surface of the liquid storage chamber 102 of the cleaning tank 100, such as the top surface of the liquid storage chamber 102 in the example shown in fig. 2 or 3, so that the internal space of the liquid storage chamber 102 can be fully utilized and the maximum pressure effect can be formed at the bottom thereof.
Of course, the same cleaning effect can be obtained by increasing the flow rate of the first liquid pump 220 or by decreasing the inner diameter of the liquid feed passage 103.
Further, controlling the loading needle 1000 to enter the washing pool 100 at the first speed includes: the sample injection needle 1000 is controlled to enter the washing tank 100 at a first speed and to be positioned right in front of the washing port 101.
Therefore, on the basis of the fluidity and the rapidness, the impact force of the cleaning liquid on the sampling needle 1000 can be increased, so that the sampling needle 1000 can be better cleaned.
Furthermore, the controller can also control the sample adding needle 1000 entering the cleaning pool 100 to rotate, or swing left and right, back and forth, and the like, so as to improve the cleaning effect of the sample adding needle 1000.
In a specific embodiment, the second flow control valve 420 is controlled to close and the sample addition needle 1000 is controlled to leave the wash tank 100 at the second speed simultaneously or before or after the first speed.
The cleaning efficiency is improved to the maximum extent on the basis of not losing the cleaning effect (mainly referring to liquid hanging prevention) by reasonably selecting the sequence of the two during actual cleaning to match the optimal matching scheme.
In addition, after controlling the second flow control valve 420 to be closed, a step of controlling the first flow control valve 410 to be closed (in this case, only the second flow control valve 420 is opened in step S30) may be further included in some cases, and the step of controlling the sample injection needle 1000 to leave the cleaning cell 100 at the second speed may be performed simultaneously or before the latter or after the latter.
At this time, it can be understood that the sequence of the liquid level reduction of the cleaning liquid is directly caused by controlling the sequence of the closing of the first liquid flow control valve 410, and at this time, the sequence of the liquid level reduction and the separation of the sampling needle 1000 from the cleaning tank 100 can be matched with the control of the separation of the sampling needle 1000 from the cleaning tank 100 at the second speed, so that the cleaning efficiency is improved to the maximum extent on the basis of not losing the cleaning effect (mainly, preventing the liquid from hanging).
Finally, although only the first speed is greater than the second speed, and no definite assignment is made to them, this is intended to protect the present application, and it will be understood that, in the actual cleaning process, the corresponding technician can assign them without any difficulty to meet different cleaning requirements.
In addition, the first speed and the second speed are not necessarily constant values, and may be values fluctuating within a certain range, in which case the first speed and the second speed may be understood as an average speed.
In addition, the components not described herein can be understood in a general sense, for example, the first liquid pump 220, the second liquid pump 320, etc. can be quantitative pumps commonly used in the art (when the usage amount of the cleaning liquid needs to be known), or other liquid pumps.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (11)
1. Cleaning fluid route system of application of sample needle, its characterized in that includes:
the cleaning tank is used for storing cleaning liquid, the cleaning tank is provided with a cleaning port which enables the cleaning liquid to shoot to a sampling needle, the cleaning tank comprises a liquid storage cavity and a liquid inlet channel, one end of the liquid inlet channel is communicated to a cleaning liquid supply device, the other end of the liquid inlet channel is communicated to the liquid storage cavity, the cleaning port is formed in the cavity wall of the liquid storage cavity, the cleaning tank comprises a peripheral frame body, an inner peripheral frame body and a liquid inlet frame body, the peripheral frame body is arranged on the periphery of the inner peripheral frame body and surrounds the inner peripheral frame body to form a waste liquid absorption chamber, the inner peripheral frame body surrounds the liquid storage cavity, the liquid inlet frame body extends from the peripheral frame body to the inner peripheral frame body and is communicated with the liquid storage cavity, and the liquid inlet frame body forms the liquid inlet channel;
the pipeline of the cleaning liquid supply device is communicated with the cleaning pool and the sampling needle and is used for supplying cleaning liquid to the cleaning pool and/or the sampling needle;
the pipeline of the waste liquid absorption device is communicated to the cleaning pool and used for recovering the waste liquid flowing out of the cleaning pool;
and at least one liquid flow control valve which is arranged on a pipeline between the cleaning liquid supply device and the cleaning pool and/or between the cleaning liquid supply device and the sampling needle and can be controlled to switch between opening and closing.
2. The cleaning solution path system according to claim 1, wherein the cleaning solution supply device comprises a cleaning solution supply reservoir and at least one first liquid pump, the first liquid pump is disposed on a pipeline between the cleaning solution supply reservoir to the cleaning reservoir and/or between the cleaning solution supply reservoir to the sampling needle, and the liquid flow control valve is disposed on a pipeline between the first liquid pump to the cleaning reservoir and/or between the first liquid pump to the sampling needle.
3. The cleaning solution path system according to claim 2, wherein the number of the first liquid pumps is one, the number of the flow control valves is two, one end of the first liquid pump is connected to the cleaning solution supply reservoir, the other end of the first liquid pump is connected to the cleaning reservoir and the sampling needle, the two flow control valves are a first flow control valve disposed between the first liquid pump and the cleaning reservoir and a second flow control valve disposed between the first liquid pump and the sampling needle, and the cleaning solution supply apparatus further comprises a three-way diverter valve disposed on a cross pipe from the first liquid pump to the cleaning reservoir and the sampling needle.
4. The cleaning solution path system of claim 1, wherein the inner peripheral frame is recessed within the outer peripheral frame such that a top surface of the outer peripheral frame is higher than a top surface of the inner peripheral frame.
5. The cleaning solution path system according to any one of claims 1 to 4, wherein the cleaning tank further comprises a waste solution frame connected between the outer frame and the inner frame and enclosing a waste solution absorption channel together with the outer frame and the inner frame, the waste solution absorption channel being in communication with the waste solution absorption chamber.
6. Cleaning device of application of sample needle, including cleaning solution way system and controller, cleaning solution way system is used for providing the washing liquid and retrieves and washs produced waste liquid, its characterized in that, cleaning solution way system includes:
the cleaning tank is used for storing cleaning liquid, the cleaning tank is provided with a cleaning port which enables the cleaning liquid to shoot to a sampling needle, the cleaning tank comprises a liquid storage cavity and a liquid inlet channel, one end of the liquid inlet channel is communicated to a cleaning liquid supply device, the other end of the liquid inlet channel is communicated to the liquid storage cavity, the cleaning port is formed in the cavity wall of the liquid storage cavity, the cleaning tank comprises a peripheral frame body, an inner peripheral frame body and a liquid inlet frame body, the peripheral frame body is arranged on the periphery of the inner peripheral frame body and surrounds the inner peripheral frame body to form a waste liquid absorption chamber, the inner peripheral frame body surrounds the liquid storage cavity, the liquid inlet frame body extends from the peripheral frame body to the inner peripheral frame body and is communicated with the liquid storage cavity, and the liquid inlet frame body forms the liquid inlet channel;
the pipeline of the cleaning liquid supply device is communicated with the cleaning pool and the sampling needle and is used for supplying cleaning liquid to the cleaning pool and/or the sampling needle;
the pipeline of the waste liquid absorption device is communicated to the cleaning pool and used for recovering the waste liquid flowing out of the cleaning pool;
and at least one liquid flow control valve, which is arranged on a pipeline between the cleaning liquid supply device and the cleaning pool and/or between the cleaning liquid supply device and the sample adding needle and can be controllably switched between opening and closing;
the controller is respectively in signal connection with the sample adding needle and the liquid flow control valve, and is used for controlling the sample adding needle to enter the washing pool at a preset first speed, controlling the sample adding needle to leave the washing pool at a preset second speed, and controlling the liquid flow control valve to be opened or closed according to a set time sequence.
7. A method for cleaning a probe using the cleaning device according to claim 6, wherein the number of the flow control valves is two, and the two flow control valves are a first flow control valve disposed between the cleaning solution supply device and the cleaning reservoir and a second flow control valve disposed between the cleaning solution supply device and the probe, respectively, the method comprising:
controlling the first liquid flow control valve to open;
controlling a sample adding needle to enter the cleaning pool at a first speed;
controlling a second flow control valve to open or controlling the second flow control valve to open and simultaneously controlling the first flow control valve to close;
controlling the second flow control valve to close;
controlling the sample adding needle to leave the washing pool at a second speed;
the first speed is greater than the second speed.
8. The method of claim 7, wherein controlling the loading needle to enter the wash chamber at the first velocity is performed after controlling the first flow control valve to open, and further comprising, after controlling the first flow control valve to open: and the cleaning liquid is formed in the cleaning pool to have a certain liquid level height.
9. The method of claim 7, wherein controlling the loading needle to enter the wash chamber at a first speed comprises: and controlling the sample adding needle to enter the cleaning pool at a first speed and be positioned right in front of the cleaning port.
10. The method of claim 7, wherein the controlling the second flow control valve to close and the controlling the loading needle to exit the wash chamber at a second rate are performed simultaneously or prior to or subsequent to the second rate.
11. The sample analyzer, comprising the cleaning device of claim 6.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911206556.5A CN112871885B (en) | 2019-11-29 | 2019-11-29 | Cleaning device for sample adding needle, cleaning liquid path system and method thereof, and sample analyzer |
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| CN201911206556.5A CN112871885B (en) | 2019-11-29 | 2019-11-29 | Cleaning device for sample adding needle, cleaning liquid path system and method thereof, and sample analyzer |
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| JP7467309B2 (en) * | 2020-10-08 | 2024-04-15 | キヤノンメディカルシステムズ株式会社 | Automatic analyzer and cleaning method |
| CN113385491A (en) * | 2021-06-16 | 2021-09-14 | 成都瀚辰光翼科技有限责任公司 | Method for preventing liquid hanging of sample adding needle |
| CN115301639B (en) * | 2022-07-13 | 2023-07-28 | 瑞莱谱(杭州)医疗科技有限公司 | Liquid path system of mass spectrum pretreatment equipment |
| CN115290873B (en) * | 2022-07-20 | 2024-05-31 | 世纪一束(杭州)医学诊断科技有限公司 | Cleaning device and chemiluminescent immunoassay analyzer thereof |
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| CN106353487B (en) * | 2015-07-14 | 2019-12-17 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling cleaning device, in-vitro diagnosis analyzer and overflow detection method |
| CN105057294A (en) * | 2015-07-31 | 2015-11-18 | 四川迈克生物医疗电子有限公司 | Sample needle cleaning method and device and sample analyzer |
| CN205270272U (en) * | 2015-12-17 | 2016-06-01 | 嘉兴凯实生物科技有限公司 | Wash pond and automatic spotting instrument |
| CN108246695B (en) * | 2018-01-16 | 2024-04-30 | 深圳迎凯生物科技有限公司 | Sampling needle cleaning device |
| CN208019025U (en) * | 2018-01-16 | 2018-10-30 | 深圳迎凯生物科技有限公司 | Sampling needle cleaning device |
| CN208928777U (en) * | 2018-08-31 | 2019-06-04 | 力德生物科技(上海)有限公司 | A kind of sample needle cleaning device |
| CN209400555U (en) * | 2019-01-08 | 2019-09-17 | 苏州康和顺医疗技术有限公司 | A kind of cleaning liquid channel system for specific protein analyzer |
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