CN112870428A - 一种显影清晰的栓塞材料及其制备方法 - Google Patents
一种显影清晰的栓塞材料及其制备方法 Download PDFInfo
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- CN112870428A CN112870428A CN202110080803.2A CN202110080803A CN112870428A CN 112870428 A CN112870428 A CN 112870428A CN 202110080803 A CN202110080803 A CN 202110080803A CN 112870428 A CN112870428 A CN 112870428A
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- 238000011161 development Methods 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title abstract description 34
- 229920000642 polymer Polymers 0.000 claims abstract description 95
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 28
- 230000010102 embolization Effects 0.000 claims abstract description 26
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- 239000000178 monomer Substances 0.000 claims abstract description 20
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 18
- WDFKEEALECCKTJ-UHFFFAOYSA-N n-propylprop-2-enamide Chemical compound CCCNC(=O)C=C WDFKEEALECCKTJ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920001577 copolymer Polymers 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 49
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- 229960004359 iodixanol Drugs 0.000 claims description 27
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims description 27
- 238000004659 sterilization and disinfection Methods 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 22
- 239000002904 solvent Substances 0.000 claims description 21
- 230000005855 radiation Effects 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims description 18
- 229960004537 ioversol Drugs 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 229960001025 iohexol Drugs 0.000 claims description 5
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims description 5
- 239000003607 modifier Substances 0.000 claims description 4
- 239000002504 physiological saline solution Substances 0.000 claims description 4
- MGFWQHJISKJHMB-UHFFFAOYSA-N 1-iodopropane-1,2,3-triol Chemical compound OCC(O)C(O)I MGFWQHJISKJHMB-UHFFFAOYSA-N 0.000 claims description 3
- 238000004113 cell culture Methods 0.000 claims description 3
- 229940008099 dimethicone Drugs 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 238000005374 membrane filtration Methods 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000008215 water for injection Substances 0.000 claims description 3
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- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 2
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- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 35
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 24
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 19
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 description 18
- 238000001816 cooling Methods 0.000 description 16
- 239000005457 ice water Substances 0.000 description 16
- 239000003999 initiator Substances 0.000 description 12
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 10
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 10
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- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- YADZBEISHVCBSJ-UHFFFAOYSA-N [I].OCC(O)CO Chemical compound [I].OCC(O)CO YADZBEISHVCBSJ-UHFFFAOYSA-N 0.000 description 5
- 230000003750 conditioning effect Effects 0.000 description 4
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- 230000003073 embolic effect Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
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- 238000011156 evaluation Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
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- 238000010603 microCT Methods 0.000 description 1
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- 231100001083 no cytotoxicity Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
原料 | 信息来源 |
丙烯酰氯 | CAS号:814-68-6 |
异丙胺 | CAS号:75-31-0 |
正丙胺 | CAS号:107-10-8 |
亚硫酸钠 | CAS号:7757-83-7 |
过硫酸钾 | CAS号:7727-21-1 |
碘佛醇 | 武汉欣欣佳丽生物科技有限公司 |
碘克沙醇 | 武汉欣欣佳丽生物科技有限公司 |
碘化油 | 上海万代制药有限公司 |
0.9%的生理盐水 | 浙江国镜药业有限公司 |
碘甘油 | 上海运佳黄浦制药有限公司 |
Claims (10)
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CN202110080803.2A CN112870428B (zh) | 2021-01-21 | 2021-01-21 | 一种显影清晰的栓塞材料及其制备方法 |
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CN202110080803.2A CN112870428B (zh) | 2021-01-21 | 2021-01-21 | 一种显影清晰的栓塞材料及其制备方法 |
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CN112870428A true CN112870428A (zh) | 2021-06-01 |
CN112870428B CN112870428B (zh) | 2022-05-27 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115068665A (zh) * | 2022-02-09 | 2022-09-20 | 上海市第十人民医院 | 一种液体栓塞剂 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030039696A1 (en) * | 2001-08-20 | 2003-02-27 | Porter Stephen C | Embolic compositions with non-cyanoacrylate rheology modifying agents |
CN102258812A (zh) * | 2011-07-08 | 2011-11-30 | 杨杨 | 一种相变可控栓塞材料及其制备方法 |
CN104645356A (zh) * | 2015-01-30 | 2015-05-27 | 复旦大学 | 一类x射线显影的热致水凝胶及其制备方法 |
CN106334213A (zh) * | 2016-08-31 | 2017-01-18 | 安疗生命科学(武汉)有限公司 | 一种血管栓塞材料、其制备方法及在药物制备中的用途 |
CN107261197A (zh) * | 2017-07-12 | 2017-10-20 | 安疗生命科学(武汉)有限公司 | 一种乳化碘油血管栓塞材料及其制备方法和应用 |
-
2021
- 2021-01-21 CN CN202110080803.2A patent/CN112870428B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030039696A1 (en) * | 2001-08-20 | 2003-02-27 | Porter Stephen C | Embolic compositions with non-cyanoacrylate rheology modifying agents |
CN102258812A (zh) * | 2011-07-08 | 2011-11-30 | 杨杨 | 一种相变可控栓塞材料及其制备方法 |
CN104645356A (zh) * | 2015-01-30 | 2015-05-27 | 复旦大学 | 一类x射线显影的热致水凝胶及其制备方法 |
CN106334213A (zh) * | 2016-08-31 | 2017-01-18 | 安疗生命科学(武汉)有限公司 | 一种血管栓塞材料、其制备方法及在药物制备中的用途 |
CN107261197A (zh) * | 2017-07-12 | 2017-10-20 | 安疗生命科学(武汉)有限公司 | 一种乳化碘油血管栓塞材料及其制备方法和应用 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115068665A (zh) * | 2022-02-09 | 2022-09-20 | 上海市第十人民医院 | 一种液体栓塞剂 |
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CN112870428B (zh) | 2022-05-27 |
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Effective date of registration: 20211119 Address after: Room a3f10, building 1, No. 25, Yongxing Road, Daxing biomedical industry base, Zhongguancun Science Park, Daxing District, Beijing 102600 Applicant after: Beijing Guanhe Medical Technology Co.,Ltd. Address before: 100089 No.6, 7th floor, 24th floor, 38 Xueyuan Road, Haidian District, Beijing Applicant before: Yang Yang |
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Denomination of invention: A clear developing embolic material and its preparation method Granted publication date: 20220527 Pledgee: Beijing Zhongguancun bank Limited by Share Ltd. Pledgor: Beijing Guanhe Medical Technology Co.,Ltd. Registration number: Y2024980017144 |