CN112870283B - A Chinese medicinal patch and its preparation method - Google Patents

A Chinese medicinal patch and its preparation method Download PDF

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CN112870283B
CN112870283B CN202110273550.0A CN202110273550A CN112870283B CN 112870283 B CN112870283 B CN 112870283B CN 202110273550 A CN202110273550 A CN 202110273550A CN 112870283 B CN112870283 B CN 112870283B
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parts
plaster
chinese medicine
medicine composition
propolis
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CN112870283A (en
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林军庭
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Beijing Zhiyang Liaoyuan Institute Of Traditional Chinese Medicine Technology
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Beijing Zhiyang Liaoyuan Institute Of Traditional Chinese Medicine Technology
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

A Chinese medicinal patch is prepared from bee venom, propolis, herba Taraxaci, radix Puerariae, rhizoma Ligustici Chuanxiong, radix Clematidis, herba Speranskiae Tuberculatae, radix Angelicae sinensis, radix Tripterygii Wilfordii, sanguis Draxonis, semen Sinapis Albae, ramulus Cinnamomi, rhizoma corydalis, and caulis Spatholobi. In the invention, bee venom, eucommia ulmoides, szechuan lovage rhizome and red sage root are used together, and mainly have the effects of detoxifying, activating blood and dissolving stasis, dispelling wind and removing dampness. The plaster has the effects of dredging meridian and collaterals, and can be used for treating scapulohumeral periarthritis, cervical vertebra, waist and leg, sciatica and rheumatic lesions, wherein the semen brassicae component can play a role in heating after contacting skin without hurting skin, and in addition, the propolis and dandelion in the formula can enable the plaster to achieve the effects of diminishing inflammation and resisting allergy, so that the phenomenon that most people are allergic to the plaster in the past is solved. Meanwhile, compared with the traditional black plaster, the plaster can be torn off and baked by fire, so that each plaster can be reused for 2-3 times.

Description

A Chinese medicinal patch and its preparation method
Technical Field
The invention relates to the field of medical patches, in particular to a traditional Chinese medicine composition patch and a preparation method thereof.
Background
The black plaster is an external preparation which is prepared by refining medicinal materials, edible vegetable oil and red lead into paste, spreading the paste on a backing material and applying the paste on skin. It has protecting, sealing and therapeutic effects, and has thick paste layer and lasting effect. The modern Chinese medicine mainly adopts 'black plaster' for promoting blood circulation to remove blood stasis and externally applying the medicine for treating the diseases. The principle of treatment is conservative therapy, and about 90% of cases have been reported to be cured by conservative therapy. For the conservation therapy, a black plaster patch is used in the traditional Chinese medicine. However, the "black plaster" has a limited effect and cannot be reused, so that there is a limitation.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition patch and a preparation method thereof, which are used for solving the problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions: a Chinese medicinal composition patch is prepared from the following raw materials in parts by weight:
1-3 parts of bee venom, 2-4 parts of propolis, 3-4 parts of dandelion, 3-4 parts of kudzuvine root, 2-3 parts of szechuan lovage rhizome, 6-7 parts of clematis root, 2-3 parts of garden balsam stem, 2-4 parts of Chinese angelica, 1-2 parts of tripterygium wilfordii, 1-2 parts of dragon's blood, 1-2 parts of brassica juncea, 1-2 parts of cassia twig, 1-2 parts of rhizoma corydalis and 2-3 parts of suberect spatholobus stem.
A preparation method of a traditional Chinese medicine composition patch comprises the following steps:
1) Taking bee venom, propolis, dandelion, kudzuvine root, szechuan lovage rhizome, clematis root, garden balsam stem, chinese angelica, common threewingnut root, dragon's blood, yellow mustard seed, cassia twig, rhizoma corydalis and suberect spatholobus stem, drying the raw materials, and grinding into 500-800 mesh ultrafine powder;
2) Placing the superfine powder in the step 1) into a container, decocting at high temperature to form paste, cooling, and coating on medical non-woven fabric yarns prepared in advance to obtain a traditional Chinese medicine composition patch;
3) After the traditional Chinese medicine composition plaster in the step 2) is used, the plaster can be repeatedly used for 2-3 times after being baked at high temperature.
Preferably, the bee venom is pungent, bitter and flat. The bee venom has an inhibitory effect on a nervous system, and an Andulcitol component in the bee venom is an antagonist of the prostate E and has strong anti-inflammatory and analgesic activities. (1) By inhibiting microsomal cyclooxygenase (prostaglandin synthase), prostaglandin synthesis is inhibited. The inhibition of brain cyclooxygenase was 70 times that of indomethacin. (2) By binding to the opioid receptors in the brain, analgesic effects are exerted through the central nerve.
Preferably, the propolis is bitter, pungent and cold in nature. Is effective in invigorating spleen and stomach meridian, and can be used for treating asthenia, turbid pathogen and lipid, and quenching thirst; it is used externally to detoxify and detumescence. Is used for treating deficiency, senilism, hyperlipidemia, and diabetes; it can be used for treating chapped skin, burn and scald.
Preferably, the ligusticum wallichii is spicy, warm and fragrant and dry, and is used for activating blood and promoting qi circulation, dispelling wind and relieving pain. For headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal stasis, block pain, carbuncle, cellulitis and pyocutaneous disease. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, chest and hypochondrium pain, traumatic injury, headache, and rheumatalgia.
Preferably, the garden balsam stem has the effects of dispelling wind and removing dampness, promoting blood circulation and relieving pain, relaxing tendons and activating collaterals, and detoxifying and removing eruption. The Chinese herbal medicines are used as medicines for folk use, and are used for treating common cold, traumatic injury, and external use for treating toxic sore, eczema and scabies.
Preferably, the tripterygium wilfordii has bitter and cold properties, has the effects of clearing heat and detoxicating, dispelling wind and dredging collaterals, relaxing tendons and activating blood circulation and the like, and is used for treating rheumatoid arthritis and nephritis.
Preferably, the radix clematidis is pungent, salty, warm and toxic; enter bladder meridian. Has effects of dispelling pathogenic wind, removing dampness, dredging collaterals, relieving pain, eliminating phlegm water, and dispelling lump accumulation. It is commonly used for stubborn arthralgia due to gout, rheumatalgia and numbness of limbs.
Preferably, the dragon's blood is pungent, salty, flat and slightly toxic. Is mainly used for dispelling blood stasis, relieving pain, stopping bleeding and promoting granulation. Treating traumatic injury, internal injury, blood stasis and pain; the traumatic hemorrhage is not enough, scrofula and ecthyma are not mixed for a long time.
Preferably, the delay Hu Suoju has the effects of promoting blood circulation, promoting qi circulation and relieving pain, and is used for treating chest and hypochondrium pain, epigastric pain, chest pain, amenorrhea and dysmenorrhea, postpartum blood stasis and traumatic injury.
In the invention, bee venom, eucommia ulmoides, szechuan lovage rhizome and red sage root are used together, and mainly have the effects of detoxifying, activating blood and dissolving stasis, dispelling wind and removing dampness. The plaster has the effects of dredging meridian and collaterals, and can be used for treating scapulohumeral periarthritis, cervical vertebra, waist and leg, sciatica and rheumatic lesions, wherein the semen brassicae component can play a role in heating after contacting skin without hurting skin, and in addition, the propolis and dandelion in the formula can enable the plaster to achieve the effects of diminishing inflammation and resisting allergy, so that the phenomenon that most people are allergic to the plaster in the past is solved. Meanwhile, compared with the traditional black plaster, the plaster can be torn off and baked by fire, so that each plaster can be reused for 2-3 times. The waste plaster can be soaked in boiled water after the plaster is applied for 2-3 times, and the plaster is used for soaking feet after being melted, thereby having the effects of activating blood circulation to dissipate blood stasis and treating beriberi.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A Chinese medicinal composition patch is prepared from the following raw materials in parts by weight:
1 part of bee venom, 4 parts of propolis, 4 parts of dandelion, 3 parts of radix puerariae, 2 parts of ligusticum wallichii, 6 parts of radix clematidis, 2 parts of garden balsam stem, 2 parts of angelica sinensis, 2 parts of tripterygium wilfordii, 1 part of dragon's blood, 1 part of semen brassicae, 1 part of cassia twig, 1 part of rhizoma corydalis and 3 parts of caulis spatholobi.
Example 2
A Chinese medicinal composition patch is prepared from the following raw materials in parts by weight:
2 parts of bee venom, 3 parts of propolis, 4 parts of dandelion, 3 parts of radix puerariae, 2 parts of ligusticum wallichii, 7 parts of radix clematidis, 3 parts of garden balsam stem, 3 parts of angelica sinensis, 2 parts of tripterygium wilfordii, 2 parts of dragon's blood, 1 part of semen brassicae, 2 parts of cassia twig, 2 parts of rhizoma corydalis and 2 parts of caulis spatholobi.
Example 3
A Chinese medicinal composition patch is prepared from the following raw materials in parts by weight:
3 parts of bee venom, 2 parts of propolis, 3 parts of dandelion, 4 parts of radix puerariae, 3 parts of ligusticum wallichii, 7 parts of radix clematidis, 3 parts of garden balsam stem, 4 parts of angelica sinensis, 1 part of tripterygium wilfordii, 2 parts of dragon's blood, 2 parts of semen brassicae, 1 part of cassia twig, 1 part of rhizoma corydalis and 2 parts of caulis spatholobi.
Example 4
A Chinese medicinal composition patch is prepared from the following raw materials in parts by weight:
2 parts of bee venom, 3 parts of propolis, 3 parts of dandelion, 3 parts of radix puerariae, 3 parts of ligusticum wallichii, 7 parts of radix clematidis, 2 parts of garden balsam stem, 4 parts of angelica sinensis, 2 parts of tripterygium wilfordii, 2 parts of dragon's blood, 2 parts of semen brassicae, 2 parts of cassia twig, 1 part of rhizoma corydalis and 3 parts of caulis spatholobi.
The preparation method of the traditional Chinese medicine composition patch in the embodiment 1-4 comprises the following steps:
1) Taking bee venom, propolis, dandelion, kudzuvine root, szechuan lovage rhizome, clematis root, garden balsam stem, chinese angelica, common threewingnut root, dragon's blood, yellow mustard seed, cassia twig, rhizoma corydalis and suberect spatholobus stem, drying the raw materials, and grinding into 500-800 mesh ultrafine powder;
2) Placing the superfine powder in the step 1) into a container, decocting at high temperature to form paste, cooling, and coating on medical non-woven fabric yarns prepared in advance to obtain a traditional Chinese medicine composition patch;
3) After the traditional Chinese medicine composition plaster in the step 2) is used, the plaster can be repeatedly used for 2-3 times after being baked at high temperature.
The invention relates to a traditional Chinese medicine clinical curative effect summary of scapulohumeral periarthritis, cervical vertebra, lumbar leg, sciatica and rheumatic disease symptoms:
1. diagnostic criteria for selected cases:
1. scapulohumeral periarthritis: with pain around the shoulder joint, limited movement, symptoms are relieved over time.
2. Cervical vertebra pain: the neck is stiff and painful, the upper limbs are debilitated, the fingers are tingled, and even the patients suddenly feel dizziness and debilitation and feel dysphagia.
3. Lumbago: waist stiffness and persistent pain in the waist when getting up in the morning.
4. Sciatica: the sciatic nerve is mainly affected by the pain in the path and distribution area. Lower back soreness and lumbar stiffness. Or weeks before onset, there is a short pain in the lower limbs during walking and exercising. Later on, the pain gradually increased and developed into severe pain. Pain begins at the waist, buttocks or hips and spreads down the posterior thigh, popliteal fossa, lateral calf and instep with an array of exacerbated burning or needle-like pain on the basis of persistent pain. And more severe at night.
2. Examples 1-4 of the present invention were treated with the following treatment regimens: selecting the prepared medicinal patch, and applying to the selected acupoint once daily. 7 days is a treatment course, and can be continuously applied for 1-4 treatment courses.
Examples 1-4 the following treatment regimen was used to select the already prepared patches, once daily, for application to the selected acupoints. 7 days is a treatment course, and can be continuously applied for 1-4 treatment courses.
In addition, the plaster can be used for 2-3 times after being baked by fire, and the waste plaster can be soaked in boiled water after being applied, and can be used for soaking feet after the plaster is melted, thereby having the effects of activating blood circulation to dissipate blood stasis and treating beriberi.
3. 1, scapulohumeral periarthritis: the patches of any one of the treatment regimens of examples 1-4 of the present invention were applied once daily, one patch at a time, to selected acupoints. 7 days is a treatment course, and can be continuously applied for 1-4 treatment courses according to the physical condition of a patient, and the treatment effect evaluation standard is tracked and observed: and (3) healing: the symptoms completely disappear, and no uncomfortable symptoms exist; the method is effective: the symptoms are obviously reduced, or part of the symptoms disappear, and the treatment needs to be continued; invalidation: the symptoms did not improve at all, but rather had a tendency to aggravate.
Clinical trials show the following table:
after 4 treatment courses, the patients with the above table have no adverse reaction, and the liver and kidney functions are detected without abnormality.
2. Cervical vertebra pain: the patches of any one of the treatment regimens of examples 1-4 of the present invention were applied once daily, one patch at a time, to selected acupoints. 7 days is a treatment course, and can be continuously applied for 1-4 treatment courses according to the physical condition of a patient, and the treatment effect evaluation standard is tracked and observed: and (3) healing: the symptoms completely disappear, and no uncomfortable symptoms exist; the method is effective: the symptoms are obviously reduced, or part of the symptoms disappear, and the treatment needs to be continued; invalidation: the symptoms did not improve at all, but rather had a tendency to aggravate.
Clinical trials show the following table:
after 4 treatment courses, the patients with the above table have no adverse reaction, and the liver and kidney functions are detected without abnormality.
3. Lumbago: the patches of any one of the treatment regimens of examples 1-4 of the present invention were applied once daily, one patch at a time, to selected acupoints. 7 days is a treatment course, and can be continuously applied for 1-4 treatment courses according to the physical condition of a patient, and the treatment effect evaluation standard is tracked and observed: and (3) healing: the symptoms completely disappear, and no uncomfortable symptoms exist; the method is effective: the symptoms are obviously reduced, or part of the symptoms disappear, and the treatment needs to be continued; invalidation: the symptoms did not improve at all, but rather had a tendency to aggravate.
Clinical trials show the following table:
after 4 treatment courses, the patients with the above table have no adverse reaction, and the liver and kidney functions are detected without abnormality.
4. Sciatica: the patches of any one of the treatment regimens of examples 1-4 of the present invention were applied once daily, one patch at a time, to selected acupoints. 7 days is a treatment course, and can be continuously applied for 1-4 treatment courses according to the physical condition of a patient, and the treatment effect evaluation standard is tracked and observed: and (3) healing: the symptoms completely disappear, and no uncomfortable symptoms exist; the method is effective: the symptoms are obviously reduced, or part of the symptoms disappear, and the treatment needs to be continued; invalidation: the symptoms did not improve at all, but rather had a tendency to aggravate.
Clinical trials show the following table:
after 4 treatment courses, the patients with the above table have no adverse reaction, and the liver and kidney functions are detected without abnormality.
The inventors have counted that the treatment effect of examples 3, 4 is a little better, and 50 patients treated with the patches prepared in examples 3, 4 have a 12% shorter average cure time than the treatment regimen of examples 1, 2.
4. Typical cases:
liu Mou A65 years old man, hubei Wu Hanren, has shoulder Zhou Yanyan for more than one year, and can not turn around in the evening, and can not wear clothes in the morning when getting up. After the Chinese medicine composition is applied to the places of the patient for three days by introduction, the patient obviously feels that the arm is lifted easily, and all symptoms disappear after more than ten days. There was no sign of relapse at the follow-up after half a year.
If a man is 74 years old, the Hubei peach is suffering from pain on the outer sides of legs caused by lumbar disc herniation for many years, the man can walk for ten minutes after squatting and resting for five minutes, the man can walk for half an hour after seven days after applying the Chinese medicine composition of the invention to my places by introducing friends, the man does not need to squat and rest, all symptoms disappear after twenty times of continuous application, and the patient is visited again after one year without recurrence.
Huang Mou when a man is 45 years old, hubei peach people can not sweep the floor at ordinary times and lift up the floor, and the lifting of the weight is not painful because of symptoms of tennis elbow caused by frequently playing tennis for half a year. The traditional Chinese medicine composition is introduced by a user and is applied externally for three times, so that the traditional Chinese medicine composition is obviously relaxed, the user can sweep the floor at home, and the basic symptoms disappear after the traditional Chinese medicine composition is continuously applied for ten times. There was no sign of relapse after a half year return visit.
Some women who are 43 years old, chongqing people, suffer from rheumatoid arthritis, wrist joint and knee joint deformation, pain, redness, swelling and stiffness, aggravate early symptoms, and slightly relieve after the afternoon temperature rises. The invention Chinese medicine combination external application patch is introduced by friends to purchase ten days, the early symptoms of feedback of patients are relieved after ten days, the patient is comfortable to apply the traditional Chinese medicine combination external application patch for warming and heating, and the invention Chinese medicine combination is purchased for one month. After half a year the symptoms of telephone feedback largely disappeared with no signs of recurrence.
Wang Mou when the women are 25 years old, the Hubei Yichang people twist the ankle during exercise and running, the wrists are not relieved after the home ice compress, the wrists are red and swollen, the traditional Chinese medicine composition is applied to the places of the women through introduction of friends for one time in the next day, the swelling is obviously reduced from the places of the women, the women can walk, the women basically recover after the women are applied for two times, and the feedback of the patients is thoroughly good after five days.
If a man is 65 years old, henan is new country, the leg fracture is once broken, plaster is applied in a certain hospital, the fracture becomes daily hidden pain after the plaster is removed, the inventor applies the Chinese medicine composition for five times to the my place, the patient just gets the fifth day, the patient has no hidden pain symptom, the man takes five times of weight to home for consolidation, and the feedback hidden pain symptom does not recur after one month.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (4)

1. A traditional Chinese medicine composition patch is characterized by being prepared from the following raw materials in parts by weight:
1-3 parts of bee venom, 2-4 parts of propolis, 3-4 parts of dandelion, 3-4 parts of kudzuvine root, 2-3 parts of szechuan lovage rhizome, 6-7 parts of clematis root, 2-3 parts of garden balsam stem, 2-4 parts of Chinese angelica, 1-2 parts of tripterygium wilfordii, 1-2 parts of dragon's blood, 1-2 parts of brassica juncea, 1-2 parts of cassia twig, 1-2 parts of rhizoma corydalis and 2-3 parts of suberect spatholobus stem.
2. The traditional Chinese medicine composition patch according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 3 parts of bee venom, 2 parts of propolis, 3 parts of dandelion, 4 parts of radix puerariae, 3 parts of ligusticum wallichii, 7 parts of radix clematidis, 3 parts of garden balsam stem, 4 parts of angelica sinensis, 1 part of tripterygium wilfordii, 2 parts of dragon's blood, 2 parts of semen brassicae, 1 part of cassia twig, 1 part of rhizoma corydalis and 2 parts of caulis spatholobi.
3. The traditional Chinese medicine composition patch according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 2 parts of bee venom, 3 parts of propolis, 3 parts of dandelion, 3 parts of radix puerariae, 3 parts of ligusticum wallichii, 7 parts of radix clematidis, 2 parts of garden balsam stem, 4 parts of angelica sinensis, 2 parts of tripterygium wilfordii, 2 parts of dragon's blood, 2 parts of semen brassicae, 2 parts of cassia twig, 1 part of rhizoma corydalis and 3 parts of caulis spatholobi.
4. The method for preparing the traditional Chinese medicine composition patch according to claim 1, which is characterized by comprising the following steps:
1) Taking bee venom, propolis, dandelion, kudzuvine root, szechuan lovage rhizome, clematis root, garden balsam stem, chinese angelica, common threewingnut root, dragon's blood, yellow mustard seed, cassia twig, rhizoma corydalis and suberect spatholobus stem, drying the raw materials, and grinding into 500-800 mesh ultrafine powder;
2) Placing the superfine powder in the step 1) into a container, decocting at high temperature to form paste, cooling, and coating on medical non-woven fabric yarns prepared in advance to obtain a traditional Chinese medicine composition patch;
3) After the traditional Chinese medicine composition plaster in the step 2) is used, the plaster can be repeatedly used for 2-3 times after being baked at high temperature.
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CN104383018A (en) * 2014-09-22 2015-03-04 林军庭 Lumbar degenerative pathological change treating traditional Chinese medicine composition plaster
CN108355005A (en) * 2018-05-04 2018-08-03 中国科学院兰州化学物理研究所 A kind of Chinese patent drug for treating the protrasion of the lumbar intervertebral disci

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383018A (en) * 2014-09-22 2015-03-04 林军庭 Lumbar degenerative pathological change treating traditional Chinese medicine composition plaster
CN108355005A (en) * 2018-05-04 2018-08-03 中国科学院兰州化学物理研究所 A kind of Chinese patent drug for treating the protrasion of the lumbar intervertebral disci

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