CN112870093A - Silica-coated medicinal powder particle and preparation method thereof - Google Patents
Silica-coated medicinal powder particle and preparation method thereof Download PDFInfo
- Publication number
- CN112870093A CN112870093A CN202110071689.7A CN202110071689A CN112870093A CN 112870093 A CN112870093 A CN 112870093A CN 202110071689 A CN202110071689 A CN 202110071689A CN 112870093 A CN112870093 A CN 112870093A
- Authority
- CN
- China
- Prior art keywords
- particles
- silica
- medicinal powder
- toothpaste
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of silicon dioxide, and particularly relates to silicon dioxide coated powder particles and a preparation method thereof. The invention firstly prepares silicon dioxide gel by a gel method, then adds medicinal powder and squeezes into filter cakes, after the filter cakes are crushed, ethyl cellulose solution is sprayed, and silicon dioxide coated medicinal powder particles are formed by a pill making machine. When the silicon dioxide coated medicinal powder particles provided by the invention are applied to toothpaste, the efficacy of medicinal powder of the toothpaste can be endowed, and the medicinal powder is released after the coating is broken in the process of brushing teeth, so that the technical problems that the medicinal powder influences the stability of toothpaste bodies and the like are effectively solved, the stability of the medicinal powder in the toothpaste is improved, and the functionality of the toothpaste is enriched.
Description
Technical Field
The invention belongs to the technical field of silicon dioxide, and particularly relates to silicon dioxide coated powder particles and a preparation method thereof.
Background
The dietary habits of people in modern society become diversified and complicated, but the cleaning of the oral cavity and teeth is not paid corresponding attention, and in addition, an incorrect tooth brushing mode often causes a large amount of fine object debris to be retained on the surfaces of the oral cavity and the teeth, while the oral cavity of people is used as a starting point of a digestive tract, hundreds of billions of bacteria exist in the oral cavity, and under the oral cavity environment, the bacteria can be greatly propagated on the surfaces of the teeth containing the object debris, so that the teeth are blackened over time to form dental caries, and even the dental diseases such as pulpitis, apical periodontitis and the like can be developed.
The toothpaste belongs to the necessities of daily life of people, and with the continuous progress of science and technology, the existing toothpaste variety is developed from single cleaning type toothpaste into multifunctional toothpaste which has complete variety and multiple functions and meets the requirements of consumption levels of different levels. The toothpaste is used for preventing canker sore and accelerating the repair of oral mucosa, is economical and practical, is simple to operate, avoids the stimulation of medicaments to intestines and stomach, and increases the compliance of patients. The medicated toothpaste is prepared by adding one or more medicines to common toothpaste, and has the function of preventing or treating oral diseases through the action of the medicines. The medicinal toothpaste is very popular with people, but the medicinal toothpaste has the possibility that the medicinal powder in the medicinal toothpaste is closely contacted with toothpaste components and reacts with the medicinal powder to lose efficacy or reduce the efficacy of the medicinal powder, and meanwhile, the medicinal powder is closely contacted with water in the toothpaste for a long time, so that the guarantee period of the toothpaste is possibly shortened.
For example, patent publication No. CN110339107A discloses a scandent schefflera root gum pain-relieving health-care toothpaste and a preparation method thereof, which is prepared by adding scandent schefflera root water extract powder, first compound water extract powder, second compound water extract powder and second compound water extract powder on the basis of a traditional toothpaste formula, so that the health-care toothpaste can effectively improve the gingival bleeding phenomenon, has an anti-inflammatory function, freshens breath and improves the use experience. Patent publication No. CN111991289A discloses an antibacterial and anti-inflammatory composition and an antibacterial and anti-inflammatory toothpaste, wherein the toothpaste is added with zedoary turmeric oil, coconut oil, peppermint oil, oregano oil, chrysanthemum flower oil and green tea extract in the formula, and is effectively compounded with natural plant components, so that various oral harmful bacteria can be bred and propagated on the surfaces of oral cavities and teeth all the time, halitosis can be prevented, and breath can be refreshed.
In conclusion, the technical problems that the efficacy of the medicinal powder is reduced or loses efficacy, the medicinal powder influences the stability of the toothpaste and the like generally exist in the prior art.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide silicon dioxide coated medicinal powder particles and a preparation method thereof. The invention uses the pores of the silicon dioxide to adsorb the medicinal powder, and then the medicinal powder particles coated with the silicon dioxide are prepared by coating the medicinal powder particles with the ethyl cellulose solution, and the medicinal powder particles are applied to toothpaste, so that the medicinal powder of the toothpaste has the efficacy of the toothpaste, the stability of the toothpaste is not influenced, and the effective period of the medicinal powder is prolonged.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a preparation method of silica-coated medicinal powder particles specifically comprises the following steps:
s1, respectively preparing a water glass solution with the molar concentration of 0.25-1.0mol/L, a sulfuric acid solution with the molar concentration of 0.25-1.0mol/L and an ethyl cellulose solution with the mass percent of 0.5-2.0%;
s2, adding 10-15m of the mixture into a reaction tank3Starting a stirring device for the sulfuric acid solution prepared in the step S1, dropwise adding the water glass solution prepared in the step S1 until the pH value in a reaction tank is 3.0-5.0, adding 6.0-10.0kg of medicinal powder after the solution is separated out of gel, and continuously stirring for 60-90min to prepare a mixture;
s3, conveying the mixture prepared in the step S2 to a filter press for filter pressing to prepare a filter cake, then crushing by a crusher, and sieving to prepare irregular small filter cake particles;
s4, pouring the irregular small filter cake particles prepared in the step S3 into a bottom spraying raw material container of a pelleting machine, starting a bottom draught fan, introducing air into a distributor at the bottom of the container to enable the particles to form a fluidized state in the container, and preparing the irregular small particles into regular small spherical particles through the pelleting machine;
s5, spraying the ethyl cellulose solution prepared in the step S1 on the bottoms of the regular small spherical particles prepared in the step S4, stopping spraying when the fineness of the small spherical particles is 25-40 meshes, continuously introducing air into a distributor at the bottom of the container, keeping supplying the air for 20-30min, and air-drying the small spheres to obtain the ethyl cellulose nano-particles.
Further, the stirring frequency in the step S2 of the preparation method of the silicon dioxide coated medicinal powder particles is 20-40 Hz.
Further, the dropping speed of the water glass solution in the step S2 of the preparation method of the silicon dioxide coated medicinal powder particles is 10-15m3/h。
Further, the fineness of the powder in the step S2 of the preparation method of the silica-coated powder particles is 120-150 meshes.
Further, the preparation method of the silicon dioxide coated medicinal powder particles is characterized in that the sieving in the step S3 is a 40-50 mesh sieve.
Further, the temperature of the air in the step S4 of the preparation method of the silicon dioxide coated medicinal powder particles is 40-60 ℃.
Further, the preparation method of the silica-coated medicinal powder particles comprises the step S5 of spraying ethyl cellulose solution under the pressure of 0.2-0.4 MPa; the temperature of the air is maintained at 40-60 ℃.
The invention also provides the silicon dioxide coated medicinal powder particles prepared by the preparation method of the silicon dioxide coated medicinal powder particles.
Furthermore, the silica-coated medicinal powder particles are applied in the preparation process of toothpaste.
The medicinal powder particles prepared by the preparation method of the silicon dioxide coated medicinal powder particles provided by the invention are small coated pills, are not in direct contact with the outside, protect medicinal powder and improve the stability of the medicinal powder in toothpaste. When the toothpaste is used for preparing toothpaste, the coating can be broken during brushing to slowly release the medicinal powder to contact with teeth and gum, so that the retention time of the medicinal powder on the teeth and gum is prolonged. In addition, the coated particles have good compatibility, and fluorine compatibility is up to more than 90%.
Compared with the prior art, the silicon dioxide coated medicinal powder particle and the preparation method thereof provided by the invention have the following advantages:
(1) the silica-coated medicinal powder particles provided by the invention coat the medicinal powder, and are isolated from other toothpaste components in toothpaste, so that the medicinal powder is protected, and the stability of the medicinal powder in the toothpaste and the stability of the toothpaste are improved;
(2) when the silica-coated medicinal powder particles provided by the invention are used in toothpaste, the medicinal powder of the toothpaste has the effect, the medicinal powder with the effect is slowly released after the coating is brushed to be broken in the tooth brushing process, and the effect of the medicinal powder starts to play a role after the medicinal powder is contacted with water, so that the effective period of the medicinal powder is prolonged;
(3) the preparation method of the silicon dioxide coated medicinal powder particles, provided by the invention, has the advantages that the air drying is carried out simultaneously in the pelleting process, the independent drying step is reduced, the preparation time is saved, and the production efficiency is improved;
(4) the medicinal powder wrapped by the silicon dioxide wrapped medicinal powder particles can be freely matched according to requirements, medicinal powder with different effects can be mixed and matched to form multi-effect medicinal powder particles, and the medicinal powder content and the mesh number of the particles can be designed according to requirements.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. Various modifications can be made by those skilled in the art based on the basic idea of the invention, but it is within the scope of the invention as long as it does not depart from the basic idea of the invention.
Example 1 preparation of silica-coated powder particles
The preparation method of the silicon dioxide coated medicinal powder particles specifically comprises the following steps:
s1, respectively preparing a water glass solution with the molar concentration of 1.0mol/L, a sulfuric acid solution with the molar concentration of 1.0mol/L and an ethyl cellulose solution with the mass percent of 2.0%;
s2, adding 15m into the reaction tank3The sulfuric acid solution prepared in the step S1 is stirred by starting the stirring device and setting the stirring frequency to be 40Hz and 15m3The water glass solution prepared in the step S1 is dripped into the reaction tank at the dripping speed/h until the pH value is 5.0,after the solution is separated out of gel, adding 10.0kg of 150-mesh medicinal powder, and continuously stirring for 90min to obtain a mixture;
s3, conveying the mixture prepared in the step S2 to a filter press for filter pressing, removing redundant sodium sulfate solution through the filter press to obtain a filter cake, crushing the filter cake by using a crusher, and sieving the filter cake with a 50-mesh sieve to obtain irregular small filter cake particles;
s4, pouring the irregular small filter cake particles prepared in the step S3 into a bottom spraying raw material container of a pelleting machine, starting a bottom draught fan, introducing air with the temperature of 60 ℃ into a distributor at the bottom of the container to enable the particles to form a fluidized state in the container, and preparing the irregular small particles into regular small spherical particles through the pelleting machine;
s5, spraying the ethyl cellulose solution prepared in the step S1 at the bottom of the regular small spherical particles prepared in the step S4, stopping spraying when the air pressure is 0.4Mpa and the fineness of the small spherical particles is 40 meshes, continuously introducing air with the temperature of 60 ℃ into a distributor at the bottom of the container, and keeping supplying the air for 30min to obtain the ethyl cellulose.
Example 2 preparation of silica-coated powder particles
The preparation method of the silicon dioxide coated medicinal powder particles specifically comprises the following steps:
s1, respectively preparing a water glass solution with the molar concentration of 0.75mol/L, a sulfuric acid solution with the molar concentration of 0.68mol/L and an ethyl cellulose solution with the mass percent of 1.3%;
s2, adding 12m into the reaction tank3The sulfuric acid solution prepared in the step S1 is stirred at 14m by starting the stirring device and setting the stirring frequency to be 30Hz3Dripping the water glass solution prepared in the step S1 into a reaction tank at the dripping speed of/h until the pH value is 4.0, adding 8.6kg of medicinal powder with the fineness of 130 meshes after the solution is precipitated out of gel, and continuously stirring for 75min to prepare a mixture;
s3, conveying the mixture prepared in the step S2 to a filter press for filter pressing, removing redundant sodium sulfate solution through the filter press to obtain a filter cake, crushing the filter cake by using a crusher, and sieving the filter cake with a 40-mesh sieve to obtain irregular small filter cake particles;
s4, pouring the irregular small filter cake particles prepared in the step S3 into a bottom spraying raw material container of a pelleting machine, starting a bottom draught fan, introducing air with the temperature of 55 ℃ into a distributor at the bottom of the container to enable the particles to form a fluidized state in the container, and preparing the irregular small particles into regular small spherical particles through the pelleting machine;
s5, spraying the ethyl cellulose solution prepared in the step S1 at the bottom of the regular small spherical particles prepared in the step S4, stopping spraying when the air pressure is 0.3Mpa and the fineness of the small spherical particles is 35 meshes, continuously introducing air with the temperature of 55 ℃ into a distributor at the bottom of the container, and keeping supplying the air for 28min to obtain the ethyl cellulose.
Example 3 preparation of silica-coated powder particles
The preparation method of the silicon dioxide coated medicinal powder particles specifically comprises the following steps:
s1, respectively preparing a water glass solution with the molar concentration of 0.25mol/L, a sulfuric acid solution with the molar concentration of 0.25mol/L and an ethyl cellulose solution with the mass percent of 0.5%;
s2, adding 10m into the reaction tank3The sulfuric acid solution prepared in the step S1 is stirred by starting the stirring device and setting the stirring frequency to be 20Hz and 10m3Dripping the water glass solution prepared in the step S1 into a reaction tank at the dripping speed of/h until the pH value is 3.0, adding 6.0kg of medicinal powder with the fineness of 120 meshes after the solution is precipitated out of gel, and continuously stirring for 60min to prepare a mixture;
s3, conveying the mixture prepared in the step S2 to a filter press for filter pressing, removing redundant sodium sulfate solution through the filter press to obtain a filter cake, crushing the filter cake by using a crusher, and sieving the filter cake with a 40-mesh sieve to obtain irregular small filter cake particles;
s4, pouring the irregular small filter cake particles prepared in the step S3 into a bottom spraying raw material container of a pelleting machine, starting a bottom draught fan, introducing air with the temperature of 40 ℃ into a distributor at the bottom of the container to enable the particles to form a fluidized state in the container, and preparing the irregular small particles into regular small spherical particles through the pelleting machine;
s5, spraying the ethyl cellulose solution prepared in the step S1 at the bottom of the regular small spherical particles prepared in the step S4, stopping spraying when the air pressure is 0.2Mpa and the fineness of the small spherical particles is 25 meshes, continuously introducing air with the temperature of 40 ℃ into a distributor at the bottom of the container, and keeping supplying the air for 20min to obtain the ethyl cellulose.
Comparative example 1 preparation of silica-coated powder particles
The preparation method of the silica-coated medicinal powder particles of the comparative example is similar to that of example 2.
The comparative example differs from example 2 in that: the ethyl cellulose solution used in this comparative example was 5% by mass.
Comparative example 2 preparation of silica-coated powder particle
The preparation method of the silica-coated medicinal powder particles of the comparative example is similar to that of example 2.
The comparative example differs from example 2 in that: no ethylcellulose solution was sprayed in step S5 of this comparative example.
Comparative example 3 preparation method of silica-coated powder particle
The preparation method of the silica-coated medicinal powder particles of the comparative example is similar to that of example 2.
The comparative example differs from example 2 in that: the temperature of the air introduced in steps S4 and S5 of this comparative example was 30 ℃.
Comparative example 4 preparation of silica-coated powder particle
The preparation method of the silica-coated medicinal powder particles of the comparative example is similar to that of example 2.
The comparative example differs from example 2 in that: in step S1 of this comparative example, a water glass solution having a molar concentration of 1.5mol/L and a sulfuric acid solution having a molar concentration of 1.5mol/L were used.
Test examples, Performance test
Test samples: the silicon dioxide prepared in the embodiments 1-3 and the comparative examples 1-4 wraps medicinal powder particles, and the medicinal powder is alcohol extract powder of saussurea involucrate;
the test method comprises the following steps:
and (3) detecting physical and chemical properties: particle size distribution: measuring the D50 particle size of the silica-coated medicinal powder particles by using a laser particle size distribution instrument (Dandong Baiteling BT-9300 ST); the drug loading rate is as follows: accurately weighing 1g of silica-coated medicinal powder particles, placing in a 25mL beaker, adding a proper amount of methanol solution, grinding the silica-coated particles with a glass rod while stirring, maintaining the process for 5min, filtering, washing the filtered silica particles with deionized water, accurately weighing the weight w of silica after drying,
application evaluation: the test sample is applied to a toothpaste formula, and the components and the mass percentage of the toothpaste formula are as follows: 60% of sorbitol, 4% of polyethylene glycol, 0.2% of saccharin sodium, 0.1% of sodium benzoate, 0.8% of carboxymethyl cellulose, 2% of sodium dodecyl sulfate, 1% of essence, 18% of friction type silicon dioxide, 4% of thickening type silicon dioxide, 0.5% of silicon dioxide coated medicinal powder particles, 0.1% of pigment and 9.3% of water;
in addition, a group of common toothpaste is set as a control group, and the toothpaste comprises the following components in percentage by weight: 60% of sorbitol, 4% of polyethylene glycol, 0.2% of saccharin sodium, 0.1% of sodium benzoate, 0.8% of carboxymethyl cellulose, 2% of sodium dodecyl sulfate, 1% of essence, 18% of friction type silicon dioxide, 4% of thickening type silicon dioxide, 0.16% of saussurea involucrate alcohol extract powder, 0.1% of pigment and 9.7% of water. In the common toothpaste, the content of the snow lotus alcohol extract powder is equal to the content of the snow lotus alcohol extract powder in the toothpaste using the silicon dioxide coated powder particles in the application example 2.
Testing the stability of the toothpaste: thermal stability: placing the test sample into a refrigerator at-8 + -1 deg.C, taking out after 8 hr, immediately placing into a constant temperature incubator at 45 + -1 deg.C, taking out after 8 hr, cooling to 25 deg.C, and checking toothpaste phase;
and (3) test results: the test results are shown in tables 1 and 2.
TABLE 1 results of physical and chemical property tests
| Group of | D50 particle size/. mu.m | Drug loading rate/%) |
| Example 1 | 125 | 11.5 |
| Example 2 | 212 | 12.7 |
| Example 3 | 250 | 11.8 |
| Comparative example 1 | 421 | 8.4 |
| Comparative example 2 | 78 | 6.5 |
| Comparative example 3 | 355 | 8.6 |
| Comparative example 4 | 125 | 7.9 |
As can be seen from Table 1, the particle size D50 of the silica-coated medicinal powder particles provided by the invention is 125-250 μm, and the drug loading rate is 11.5-12.7%, wherein the particle size of the silica-coated medicinal powder particles prepared in example 2 is moderate, and the drug loading rate is good, and the silica-coated medicinal powder particles are the best embodiment of the invention.
Compared with example 2, the mass percentage of the ethyl cellulose solution is increased in comparative example 1, but the drug loading rate of the prepared silica-coated drug powder particles is reduced, because the thickness of the ethyl cellulose coating is increased, so that the drug powder cannot be effectively released; in comparative example 2, no ethyl cellulose solution was sprayed, but the drug loading rate of the prepared silica-coated powder particles was reduced, which is caused by the reaction of the powder with the toothpaste formulation; comparative example 4 in step S1, a water glass solution having a molar concentration of 1.5mol/L and a sulfuric acid solution having a molar concentration of 1.5mol/L, the drug loading rate of the silica-coated drug powder particles was decreased because the silica particles generated during the reaction process were dense, had a small pore size, adsorbed drug powder and had a low drug loading rate.
Table 2 toothpaste stability test results
| Group of | Thermal stability |
| Example 1 | No water seepage, no crack, no inverse coarse, no odor and no air expansion |
| Example 2 | No water seepage, no crack, no inverse coarse, no odor and no air expansion |
| Example 3 | No water seepage, no crack, no inverse coarse, no odor and no air expansion |
| Comparative example 1 | No water seepage, no crack, no inverse coarse, no odor and no air expansion |
| Comparative example 2 | No water seepage, no crack, no coarse, off-flavor, no air expansion |
| Comparative example 3 | Has water seepage, no crack, no coarse, off-flavor and air expansion |
| Comparative example 4 | No water seepage, no crack, no inverse coarse, no odor and no air expansion |
| Control group | Demixing and cracking of paste |
As can be seen from table 1, the silica-coated powder particles provided by the present invention have good thermal stability when applied to toothpaste, which fully illustrates that the present invention effectively solves the technical problem that the application of powder in a toothpaste formulation affects the stability of toothpaste. In comparative example 2, no ethylcellulose solution was sprayed, so that the powder reacted with other ingredients of the toothpaste by direct contact, resulting in a slight deterioration of the powder and a deterioration of the toothpaste. In comparative example 3, air is introduced at 30 ℃ in steps S4 and S5, and the air drying temperature is low in the particle preparation process, so that the moisture content of the particles is high, the medicinal powder is easy to ferment and deteriorate, the thermal stability of the toothpaste is poor, and the toothpaste has the phenomena of water seepage, taste change and air expansion.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art will recognize that changes may be made to the embodiments described above without departing from the spirit and scope of the invention. Therefore, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the technical spirit of the present invention are covered by the claims of the present invention.
Claims (9)
1. A preparation method of silica-coated medicinal powder particles is characterized by comprising the following steps:
s1, respectively preparing a water glass solution with the molar concentration of 0.25-1.0mol/L, a sulfuric acid solution with the molar concentration of 0.25-1.0mol/L and an ethyl cellulose solution with the mass percent of 0.5-2.0%;
s2, adding 10-15m of the mixture into a reaction tank3Starting a stirring device for the sulfuric acid solution prepared in the step S1, dropwise adding the water glass solution prepared in the step S1 until the pH value in a reaction tank is 3.0-5.0, adding 6.0-10.0kg of medicinal powder after the solution is separated out of gel, and continuously stirring for 60-90min to prepare a mixture;
s3, conveying the mixture prepared in the step S2 to a filter press for filter pressing to prepare a filter cake, then crushing by a crusher, and sieving to prepare irregular small filter cake particles;
s4, pouring the irregular small filter cake particles prepared in the step S3 into a bottom spraying raw material container of a pelleting machine, starting a bottom draught fan, introducing air into a distributor at the bottom of the container to enable the particles to form a fluidized state in the container, and preparing the irregular small particles into regular small spherical particles through the pelleting machine;
s5, spraying the ethyl cellulose solution prepared in the step S1 on the bottoms of the regular small spherical particles prepared in the step S4, stopping spraying when the fineness of the small spherical particles is 25-40 meshes, continuously introducing air into a distributor at the bottom of the container, keeping supplying the air for 20-30min, and air-drying the small spheres to obtain the ethyl cellulose nano-particles.
2. The method for preparing silica-coated pharmaceutical powder particles as claimed in claim 1, wherein the stirring frequency in step S2 is 20 to 40 Hz.
3. The silica-coated pharmaceutical powder particle of claim 1Characterized in that the dropping speed of the water glass solution in the step S2 is 10-15m3/h。
4. The method as claimed in claim 1, wherein the fineness of the silica-coated powder in step S2 is 120-150 mesh.
5. The method for preparing silica-coated pharmaceutical powder particles as claimed in claim 1, wherein the sieving in step S3 is a 40-50 mesh sieve.
6. The method for preparing silica-coated pharmaceutical powder particles as claimed in claim 1, wherein the air temperature in step S4 is 40-60 ℃.
7. The method for preparing silica-coated pharmaceutical powder particles as claimed in claim 1, wherein the injection pressure of the ethyl cellulose solution in the step S5 is 0.2 to 0.4 Mpa; the temperature of the air is maintained at 40-60 ℃.
8. Silica-coated pharmaceutical powder particles obtainable by the process for the preparation of silica-coated pharmaceutical powder particles according to any one of claims 1 to 7.
9. Silica-coated pharmaceutical powder particles according to claim 8, for use in the preparation of toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110071689.7A CN112870093A (en) | 2021-01-19 | 2021-01-19 | Silica-coated medicinal powder particle and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110071689.7A CN112870093A (en) | 2021-01-19 | 2021-01-19 | Silica-coated medicinal powder particle and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112870093A true CN112870093A (en) | 2021-06-01 |
Family
ID=76051347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110071689.7A Pending CN112870093A (en) | 2021-01-19 | 2021-01-19 | Silica-coated medicinal powder particle and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112870093A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417390A (en) * | 2013-07-23 | 2013-12-04 | 广州立白企业集团有限公司 | Toothpaste containing carbon coating particles |
| CN109481374A (en) * | 2018-10-26 | 2019-03-19 | 苏州绿叶日用品有限公司 | Application of the bioactivity glass enwrapped granule in oral care product |
| CN111643415A (en) * | 2020-06-18 | 2020-09-11 | 广州市飞雪材料科技有限公司 | Double-layer silicon dioxide coated particle and preparation method and application thereof |
| CN111874918A (en) * | 2020-07-30 | 2020-11-03 | 广州市飞雪材料科技有限公司 | Silica for toothpaste with anti-allergy and antibacterial effects and preparation method thereof |
-
2021
- 2021-01-19 CN CN202110071689.7A patent/CN112870093A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417390A (en) * | 2013-07-23 | 2013-12-04 | 广州立白企业集团有限公司 | Toothpaste containing carbon coating particles |
| CN109481374A (en) * | 2018-10-26 | 2019-03-19 | 苏州绿叶日用品有限公司 | Application of the bioactivity glass enwrapped granule in oral care product |
| CN111643415A (en) * | 2020-06-18 | 2020-09-11 | 广州市飞雪材料科技有限公司 | Double-layer silicon dioxide coated particle and preparation method and application thereof |
| CN111874918A (en) * | 2020-07-30 | 2020-11-03 | 广州市飞雪材料科技有限公司 | Silica for toothpaste with anti-allergy and antibacterial effects and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI395745B (en) | Catechu acid coloring inhibition method and toothpaste composition | |
| CN105267234A (en) | Composition for relieving xerostomia and preparation method thereof | |
| US9517197B1 (en) | Toothpaste composition containing ganoderma lucidum component and preparation method thereof | |
| CN112691057B (en) | Compound efficacy toothpaste and preparation method thereof | |
| CN110314110A (en) | A kind of effervescent tablet type mouthwash and preparation method thereof | |
| CN101292943B (en) | Nanometer zinc oxide toothpaste | |
| KR20110027047A (en) | Zeolite oral capsule powder and the oral composition containing thereof | |
| KR101272738B1 (en) | Method for the preparation of oral capsule and the oral composition containing the capsule powder prepared by the same | |
| CN108339122B (en) | Preparation method and application of anti-allergy bioactive glass powder | |
| CN110946778A (en) | Toothpaste with anti-inflammation and bacteriostasis functions | |
| CN112870093A (en) | Silica-coated medicinal powder particle and preparation method thereof | |
| CN105663014A (en) | Inflammation diminishing and whitening toothpaste containing rhizoma coptidis and fresh ginger | |
| CN104721224B (en) | A kind of dry alleviates gargle and preparation method thereof | |
| KR20150061762A (en) | Oral composition having anti-detal caries efficacy | |
| CN115154501B (en) | Composition for oral cavity repair, gel preparation prepared from composition and application of gel preparation | |
| CN108186614B (en) | Bioactive glass composite membrane, preparation method and application thereof | |
| CN110623848A (en) | Dentifrice with function of repairing oral mucosa and preparation method thereof | |
| KR20120050104A (en) | Dentifrice composition containing mastic extracts and method for preparing the same | |
| CN113713113B (en) | Composition for treating oral mucosa diseases and preparation method thereof | |
| CN105919960B (en) | A kind of roxithromycin dispersing tablet and preparation method thereof | |
| CN110840788B (en) | Toothpaste formula | |
| US10603250B2 (en) | One-pack type dentinal tubule occlusion material | |
| KR20190057727A (en) | Composition for improving bronchial health improved palatability | |
| CN109846794B (en) | Composition, microsphere containing composition and preparation method of microsphere | |
| CN1631395A (en) | Gingko leaf sustained release formulation and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210601 |