CN112848283A - 3D printing method for large-size complex-structure bone tissue - Google Patents

3D printing method for large-size complex-structure bone tissue Download PDF

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Publication number
CN112848283A
CN112848283A CN202110020548.2A CN202110020548A CN112848283A CN 112848283 A CN112848283 A CN 112848283A CN 202110020548 A CN202110020548 A CN 202110020548A CN 112848283 A CN112848283 A CN 112848283A
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China
Prior art keywords
bone tissue
printing
printing method
models
sub
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Pending
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CN202110020548.2A
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Chinese (zh)
Inventor
李修往
桑宏勋
吴家昌
方国芳
张晓强
吴铭杰
罗志平
郑杰
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Shenzhen Hospital of Southern Medical University
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Shenzhen Hospital of Southern Medical University
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Priority to CN202110020548.2A priority Critical patent/CN112848283A/en
Publication of CN112848283A publication Critical patent/CN112848283A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10Processes of additive manufacturing
    • B29C64/106Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/124Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/30Auxiliary operations or equipment
    • B29C64/386Data acquisition or data processing for additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00Processes of additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00Data acquisition or data processing for additive manufacturing

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)

Abstract

The invention provides a 3D printing method of large-size complex-structure bone tissues, which comprises the following steps: establishing a bone tissue model by utilizing modeling software according to bone tissue to be printed; segmenting the bone tissue model into at least two sub-models; respectively guiding the at least two sub-models into a printer for 3D printing to generate a bone tissue structure module; and integrating the bone tissue structure into the large-size complex-structure bone tissue by adopting a bonding mechanism. The method provided by the invention is particularly suitable for printing bone tissue models with large-size complex structures such as spines, pelvises, long bones of limbs and the like; the printing success rate of the divided simple structure module is greatly improved; even if the printing failure of the simple module after the division is realized, only the module is readjusted and printed, the printing effect of other modules is not influenced, the printing time and the printing material are saved, and the printing efficiency is improved.

Description

3D printing method for large-size complex-structure bone tissue
Technical Field
The invention relates to the technical field of medical materials, in particular to a 3D printing method of a large-size complex-structure bone tissue model.
Background
3D printing is a kind of additive manufacturing technology which adds and stacks materials layer by layer to manufacture three-dimensional objects, software modeling is carried out through a computer, the built three-dimensional objects are partitioned into sections layer by layer, a printer reads the section information, the sections are printed layer by using liquid, powder and other materials, and finally, the sections are bonded together to manufacture a solid structure.
The 3D printing technology is not only applied to industrial manufacturing, but also the application of 3D printing in the medical field has become an important trend in the development of digital medicine, especially in the field of bone surgery. The accurate planning of the scheme of performing the operation before the art can be carried out through the equal proportion bone tissue model of printing the patient before the art, the accuracy of location in the operation can be ensured through the observation of the equal proportion bone tissue model in the operation to can promote the location precision of operation, reduce the time and the patient's amount of bleeding of operation, can reduce the radiation dose of wound and the repeated perspective in the art. The effect of the surgery can be assessed post-operatively by means of the printed model. However, the efficient and high-quality printing of accurate bone tissue models with equal proportion and complete matching with patients is often limited by the type of the printer, the printing range of the printer and the volume and structural complexity of the printed bone tissue models, and particularly, when large-size bone tissue models such as spines, pelvises, long bones of limbs and the like are printed, the problems that the printing range is exceeded, and the printing fails and the printing is repeated are caused. For full spine printing and full pelvis printing, the whole model is frequently reprinted due to printing collapse of a local complex structure, and materials and time are wasted.
Therefore, there is a need for an improved 3D printing method for large-sized complex bone tissue.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a 3D printing method of large-size complex-structure bone tissues.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a 3D printing method of large-size complex-structure bone tissues, which comprises the following steps:
step one, establishing a bone tissue model by utilizing modeling software according to bone tissue to be printed;
step two, the bone tissue model is divided into at least two sub-models;
step three, respectively guiding the at least two sub-models into a printer for 3D printing to generate a bone tissue structure module;
and step four, integrating the bone tissue structure into the large-size complex-structure bone tissue by adopting a bonding mechanism.
Further, the material of the large-sized complex-structured bone tissue is selected from one of photosensitive resin and bioceramic material.
Further, the modeling software is selected from the group consisting of Mimics, 3Dmax, PROE, UG, AUTOCAD and SOLIDWORKS.
Further, the number of the submodels is 2.
Further, the large-sized complex-structured bone tissue is a long bone of the spine, pelvis, or limbs.
Further, the key mechanism is of a pin structure.
Further, the material of the bonding mechanism is selected from one of photosensitive resin and bioceramic material.
Furthermore, the combining ends of the sub-models are mutually matched clamping structures.
Further, the printer is a photocuring 3D printer.
By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:
the method provided by the invention is particularly suitable for printing bone tissue models with large-size complex structures such as spines, pelvises, long bones of limbs and the like; the printing success rate of the divided simple structure module is greatly improved; even if the printing failure of the simple module after the division is realized, only the module is readjusted and printed, the printing effect of other modules is not influenced, the printing time and the printing material are saved, and the printing efficiency is improved.
Drawings
FIG. 1 is a schematic diagram of a large-sized complex bone tissue model to be printed according to an embodiment of the present invention
FIG. 2 is a schematic diagram of the individual modules of a large-sized complex bone tissue model after segmentation according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of the complete structure of the independent modules integrated by the bonding mechanism according to one embodiment of the present invention;
fig. 4 is a diagram illustrating the practical effect of two printed modules combined into a whole by a bonding structure according to an embodiment of the present invention.
Detailed Description
The invention provides a 3D printing method of large-size complex-structure bone tissue, aiming at the problem that the probability of one-time printing forming failure of large-size bone tissue models such as spines, pelvises, long bones of limbs and the like is high. The method comprises the following steps:
step one, establishing a bone tissue model by utilizing modeling software according to bone tissue to be printed;
step two, the bone tissue model is divided into at least two sub-models;
step three, respectively guiding the at least two sub-models into a printer for 3D printing to generate a bone tissue structure module;
and step four, integrating the bone tissue structure into the large-size complex-structure bone tissue by adopting a bonding mechanism.
In a preferred embodiment of the present invention, the material of the large-sized complex-structured bone tissue is selected from one of photosensitive resin and bioceramic material
In a preferred embodiment of the invention, the modeling software is selected from the group consisting of Mimics, 3Dmax, PROE, UG, AUTOCAD and SOLIDWORKS.
In a preferred embodiment of the present invention, the number of the submodels is 2.
In a preferred embodiment of the present invention, the large-sized complex-structured bone tissue is a long bone of a spine, a pelvis or a limb.
The bonding mechanism is mainly used for reassembling and assembling the divided modules, and is not particularly set or limited. In a preferred embodiment of the present invention, the key mechanism is a pin structure.
In a preferred embodiment of the invention, the material of the bonding mechanism is selected from one of a photosensitive resin and a bio-ceramic material.
In a preferred embodiment of the invention, the combining ends of the sub-model are mutually matched clamping structures, and the combination of the sub-model and the bone tissues of the sub-model is reinforced by matching with the bonding mechanism.
In a preferred embodiment of the present invention, the printer is a photo-curing 3D printer.
The present invention will be described in detail and specifically with reference to the following examples to facilitate better understanding of the present invention, but the following examples do not limit the scope of the present invention.
In the examples, the conventional methods were used unless otherwise specified, and reagents used were those conventionally commercially available or formulated according to the conventional methods without specifically specified.
Example 1
Printing of the spine malformation model in this embodiment is an example, because the length of the whole spine exceeds the range of the printer and the local structure is complex due to serious malformation, if the spine is not divided into simple modules, the spine malformation model cannot be printed on the printer, even if the spine malformation model is adjusted to be put down, the risk of overall printing failure due to local collapse is also present, and therefore the spine malformation model needs to be divided into smaller modules, and the specific operation method is as follows:
step one, establishing a spinal deformity model (as shown in figure 1) by using Mimics modeling software;
step two, dividing the spine malformation model into two independent sub-models (as shown in fig. 2), wherein the model structure after the two independent sub-models are integrated is shown in fig. 3;
respectively leading the two independent sub-models into a photocuring printer for 3D printing to generate an independent bone tissue structure module;
and step four, integrating the bone tissue structure module into the whole spinal column tissue by adopting a bonding mechanism in a pin structure shape, as shown in fig. 4.
The printing success rate of the method is remarkably improved, the printing time and materials are saved, and the printed model can be split and combined for clinical diagnosis and treatment, so that the method is more flexible and convenient.
The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.

Claims (9)

1. A3D printing method for large-size complex-structure bone tissues is characterized by comprising the following steps:
step one, establishing a bone tissue model by utilizing modeling software according to bone tissue to be printed;
step two, the bone tissue model is divided into at least two sub models;
step three, respectively guiding the at least two sub-models into a printer for 3D printing to generate a bone tissue structure module;
and step four, integrating the bone tissue structure into the large-size complex-structure bone tissue by adopting a bonding mechanism.
2. The 3D printing method according to claim 1, wherein the material of the large-sized complex-structured bone tissue is selected from one of a photosensitive resin and a bio-ceramic material.
3. 3D printing method according to claim 1, characterized in that the modeling software is selected from mics, 3Dmax, pro, UG, AUTOCAD or SOLIDWORKS.
4. The 3D printing method according to claim 1, wherein the number of submodels is 2.
5. The 3D printing method according to claim 4, wherein the large-sized complex-structured bone tissue is a spine, pelvis, or extremity long bone.
6. The 3D printing method according to claim 1, wherein the bonding mechanism is a pin structure.
7. The 3D printing method according to claim 1, wherein a material of the bonding mechanism is selected from one of a photosensitive resin and a bio-ceramic material.
8. The 3D printing method according to claim 1, wherein the coupling ends of the sub-models are mutually matched snap-fit structures.
9. The 3D printing method according to claim 1, wherein the printer is a photo-curing 3D printer.
CN202110020548.2A 2021-01-07 2021-01-07 3D printing method for large-size complex-structure bone tissue Pending CN112848283A (en)

Priority Applications (1)

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CN202110020548.2A CN112848283A (en) 2021-01-07 2021-01-07 3D printing method for large-size complex-structure bone tissue

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113878876A (en) * 2021-09-15 2022-01-04 中国第一汽车股份有限公司 3D printing structure of large-size automotive interior part and 3D printing manufacturing method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104226988A (en) * 2014-08-25 2014-12-24 深圳光韵达光电科技股份有限公司 3D printing manufacturing method for large-size part

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104226988A (en) * 2014-08-25 2014-12-24 深圳光韵达光电科技股份有限公司 3D printing manufacturing method for large-size part

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113878876A (en) * 2021-09-15 2022-01-04 中国第一汽车股份有限公司 3D printing structure of large-size automotive interior part and 3D printing manufacturing method thereof

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Application publication date: 20210528