CN105748173B - The preparation method and device of orbital reconstruction material - Google Patents
The preparation method and device of orbital reconstruction material Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
- A61F2002/2878—Skull or cranium for orbital repair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The invention provides a kind of preparation method of orbital reconstruction material.This method includes：Obtain the eye bone medical image of existing object；Image procossing is carried out to eye bone medical image, position to be repaired is detected；Extract the texture data at position to be repaired；Wherein, texture data includes：Socket of the eye inwall skeleton data, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, margo supraorbitalis skeleton data, socket of the eye lower edge skeleton data, socket of the eye inner edge skeleton data and the socket of the eye outer rim skeleton data at position to be repaired；The texture data at position to be repaired is handled using three-dimensional modeling method, the three-dimensional digital model at position to be repaired is obtained；By the data input of the three-dimensional digital model at position to be repaired to polyether-ether-ketone 3D printer, the physical model at position to be repaired is printed.The present invention improves the matching degree of orbital reconstruction model and eye bone.
Description
Technical field
The present invention relates to technical field of medical instruments, in particular to a kind of preparation method of orbital reconstruction material and
Device.
Background technology
Show as margo orbitalis, socket of the eye wall fracture and defect more orbital malformation and orbital injury, endophthalmos, diplopia can be caused and regarded
Dysfunction, and have a strong impact on face appearance.Accordingly, it would be desirable to be repaired to eye socket, to improve visual function, and with beautification face
The effect in portion.
Conventional repair materials have hydroxyapatite, artificial bone, titanium metal material etc. at present.These materials have certain
Biocompatibility and plasticity, but make using these materials that repairing model manufacture difficulty is big, time-consuming, and with eye bone
It is relatively low with degree.
For above-mentioned orbital reconstruction model and eye bone matching degree it is relatively low the problem of, effective solution is not yet proposed at present
Certainly scheme.
The content of the invention
In view of this, the purpose of the embodiment of the present invention is the preparation method and device for providing a kind of orbital reconstruction material,
To improve orbital reconstruction model and eye bone matching degree, more preferable cosmetic result is reached.
In a first aspect, the embodiments of the invention provide a kind of preparation method of orbital reconstruction material, this method includes：Obtain
The eye bone medical image of existing object；Image procossing is carried out to eye bone medical image, detected to be repaired
Multiple position；Extract the texture data at position to be repaired；Wherein, texture data includes：The socket of the eye inwall at position to be repaired
Skeleton data, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, margo supraorbitalis skeleton data, socket of the eye lower edge bone number
According to, socket of the eye inner edge skeleton data and socket of the eye outer rim skeleton data；The texture data at position to be repaired is entered using three-dimensional modeling method
Row processing, obtains the three-dimensional digital model at position to be repaired；By the data input of the three-dimensional digital model at position to be repaired to poly-
Ether ether ketone 3D printer, prints the physical model at position to be repaired.
With reference in a first aspect, the embodiments of the invention provide the possible embodiment of the first of first aspect, wherein, it is right
Eye bone medical image carries out image procossing, detects that position to be repaired includes：To eye bone medical image
Image enhancement processing, image dividing processing, image conversion process and image detection processing are carried out, position to be repaired is detected.
With reference in a first aspect, the embodiments of the invention provide the possible embodiment of second of first aspect, wherein, profit
Processing is carried out to the texture data at position to be repaired with three-dimensional modeling method includes：To the texture data at position to be repaired
Carry out data preparation processing, modeling processing and model export processing.
With reference in a first aspect, the embodiments of the invention provide the possible embodiment of the third of first aspect, wherein, when
The eye bone medical image of preceding object includes the one or more in data below：X-ray image data, computerized tomography
Scan image data, positron emission tomography view data, ultrasound image data and nuclear magnetic resonance image data.
With reference in a first aspect, the embodiments of the invention provide the possible embodiment of the 4th of first aspect kind, wherein, will
The data input of the three-dimensional digital model at position to be repaired prints the entity mould at position to be repaired to polyether-ether-ketone 3D printer
Type includes：The data of the three-dimensional digital model at position to be repaired are converted into stereolithography art file；Photocuring is stood
Figure modelling art file is inputted to polyether-ether-ketone 3D printer, prints the physical model at position to be repaired.
With reference to first aspect and first aspect the first to the 4th kind of possible embodiment, the embodiment of the present invention is provided
5th kind of possible embodiment of first aspect, wherein, the material of polyether-ether-ketone 3D printer includes：Polyether-ether-ketone and carbon
Fiber reinforcement polyether-ether-ketone.
Second aspect, the embodiments of the invention provide a kind of producing device of orbital reconstruction material, the device includes：Eye
Bone medical image acquisition module, the eye bone medical image for obtaining existing object；Image procossing is detected
Module, for carrying out image procossing to eye bone medical image, detects position to be repaired；Data extraction module, is used
In the texture data for extracting position to be repaired；Wherein, texture data includes：The socket of the eye inwall bone number at position to be repaired
According to, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, margo supraorbitalis skeleton data, socket of the eye lower edge skeleton data, socket of the eye
Inner edge skeleton data and socket of the eye outer rim skeleton data；Modeling module, for utilizing knot of tissue of the three-dimensional modeling method to position to be repaired
Structure data are handled, and obtain the three-dimensional digital model at position to be repaired；Print module, for by three dimensions at position to be repaired
The data input of word model prints the physical model at position to be repaired to polyether-ether-ketone 3D printer.
With reference to second aspect, the embodiments of the invention provide the possible embodiment of the first of second aspect, wherein, eye
Portion's bone medical image acquisition module includes：X-ray image acquiring unit, for obtaining current right by X-ray Image-forming instrument
The x-ray image of the eye bone of elephant；Computed tomography image acquiring unit, for obtaining current by computed tomography scanner
The computed tomography image of object；Positron faultage image acquiring unit, for obtaining existing object by positron emission tomography instrument
Positron faultage image；Ultrasound image acquisition unit, the ultrasonoscopy for obtaining existing object by diasonograph；Nuclear-magnetism
Resonance image acquiring unit, the nuclear magnetic resonance image for obtaining existing object by NMR.
With reference to second aspect, the embodiments of the invention provide the possible embodiment of second of second aspect, wherein, build
Mould module includes：Data preparation unit, data preparation processing is carried out for the texture data to position to be repaired；At modeling
Unit is managed, for being modeled processing to the data that data preparation unit is exported；Model lead-out unit, for single to modeling processing
The model of member output carries out export processing.
With reference to second aspect, the embodiments of the invention provide the possible embodiment of the third of second aspect, wherein, beat
Impression block includes：Date Conversion Unit, it is three-dimensional for the data of the three-dimensional digital model at position to be repaired to be converted into photocuring
Modeling file；Input block, for stereolithography art file to be inputted to polyether-ether-ketone 3D printer.
The preparation method and device of a kind of orbital reconstruction material provided in an embodiment of the present invention, by obtaining existing object
Eye bone medical image, processing monitoring and extraction is carried out to above-mentioned view data, and carry out three-dimensional modeling and print
Physical model, can produce the entity at the to be repaired position higher with the orbit bones matching degree of the object for existing object
Model, and manufacture difficulty is low, it is convenient and swift.
To enable the above objects, features and advantages of the present invention to become apparent, preferred embodiment cited below particularly, and coordinate
Appended accompanying drawing, is described in detail below.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be attached to what is used required in embodiment
Figure is briefly described, it will be appreciated that the following drawings illustrate only certain embodiments of the present invention, therefore is not construed as pair
The restriction of scope, for those of ordinary skill in the art, on the premise of not paying creative work, can also be according to this
A little accompanying drawings obtain other related accompanying drawings.
Fig. 1 shows the preparation method flow chart for the orbital reconstruction material that the embodiment of the present invention is provided；
Fig. 2 shows a kind of structural representation of the producing device for orbital reconstruction material that the embodiment of the present invention is provided.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
Middle accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only
It is a part of embodiment of the invention, rather than whole embodiments.The present invention being generally described and illustrated herein in the accompanying drawings is real
Applying the component of example can be arranged and be designed with a variety of configurations.Therefore, it is of the invention to what is provided in the accompanying drawings below
The detailed description of embodiment is not intended to limit the scope of claimed invention, but is merely representative of the selected reality of the present invention
Apply example.Based on embodiments of the invention, the institute that those skilled in the art are obtained on the premise of creative work is not made
There is other embodiment, belong to the scope of protection of the invention.
In view of existing conventional repair materials modelling difficulty is big, time-consuming, and with eye bone matching degree compared with
Low the problem of, the embodiments of the invention provide a kind of preparation method of orbital reconstruction material and device, the technology can use phase
The software and equipment of pass are realized, are described below by embodiment.
A kind of preparation method flow chart of orbital reconstruction material shown in Figure 1, this method comprises the following steps：
Step S102, obtains the eye bone medical image of existing object；
Step S104, carries out image procossing to eye bone medical image, detects position to be repaired；
Step S106, extracts the texture data at position to be repaired；Wherein, texture data includes：Portion to be repaired
Socket of the eye inwall skeleton data, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, margo supraorbitalis skeleton data, the socket of the eye of position
Lower edge skeleton data, socket of the eye inner edge skeleton data and socket of the eye outer rim skeleton data；
Step S108, is handled the texture data at position to be repaired using three-dimensional modeling method, obtains to be repaired
The three-dimensional digital model at position；Wherein, the software of three-dimensional modeling can be CATIA (Computer Aided Tri-
Dimensional Interface Application), SolidWorks, UniGrapphics, AutoCAD etc..
Step S110, by the data input of the three-dimensional digital model at position to be repaired to polyether-ether-ketone 3D printer, printing
Go out the physical model at position to be repaired.
Unless specifically stated otherwise, part and the relative step of step, the digital table otherwise illustrated in these embodiments
It is not limit the scope of the invention up to formula and numerical value.
In the above method of the present embodiment, carried out by the eye bone medical image to existing object at image
The processing such as reason, data extraction, three-dimensional modeling and 3D printing, obtain the reality higher with the reparation position matching degree of existing object
Body Model；And the above method reduces the manufacture difficulty of model, reduces Production Time.
Data volume in view of medical image is huge, and extracts from view data the critical data at position to be repaired
Difficulty is larger, and the embodiment of the present invention carries out image procossing to eye bone medical image, detect to treat when implementing
Repair position；Above-mentioned image procossing can include：Image enhancement processing, image segmentation are carried out to eye bone medical image
Processing, image conversion process and image detection processing, detect position to be repaired.In specific implementation, at above-mentioned image enhaucament
Original unsharp image can be apparent from or emphasized some features interested by reason, suppressed uninterested feature, made
Improvement picture quality, abundant information amount, strengthen image interpretation and recognition effect；Above-mentioned image dividing processing can be image point
Into several regions specific, with unique properties and interesting target is proposed, existing image partition method mainly includes：
Dividing method based on threshold value, the dividing method based on region, the dividing method based on edge and point based on particular theory
Segmentation method etc.；Above-mentioned image conversion process be in order to represent image with orthogonal function or orthogonal matrix and original image made two
Dimensional linear inverible transform, the image after conversion is often more beneficial for feature extraction, enhancing, compression and Image Coding；It is above-mentioned
Image detection processing is based primarily upon image recognition processing, can be compared, processed with current information by the information of storage,
Realize image confirming.
The mode of above-mentioned image procossing, can extract the data at position to be repaired from substantial amounts of medical image,
Accurate data standard is provided for follow-up modelling.
Further, in order to the 2-D data extracted from medical image information is converted into threedimensional model, this hair
Bright embodiment is included when realizing using three-dimensional modeling method to the texture data progress processing at position to be repaired：To be repaired
The texture data at multiple position carries out data preparation processing, modeling processing and model export processing；It is above-mentioned when implementing
Data preparation processing is main to be included mark modeling scope, trimming contour, obtains the steps such as modeling region, rotation translation data；
Above-mentioned modeling processing is main to be included importing data, export contour node data, interpolation, the coordinate data imported after interpolation, profit
With steps such as a construction face, the side surface configurations of model；Above-mentioned model export processing is main to be included merging side and bottom surface, export number
According to, change file, set up the steps such as project file.
By the processing of above-mentioned three-dimensional modeling, can quickly and accurately it be obtained according to the medical image of existing object
The threedimensional model at position to be repaired；And the index such as shape, the size of the threedimensional model and the eye bone of above-mentioned existing object
It is higher with degree.
When implementing, the eye bone medical image of above-mentioned existing object can include one in data below
Plant or a variety of：X-ray image data, computed tomography images data, positron emission tomography view data, ultrasonography number
According to nuclear magnetic resonance image data.Above-mentioned x-ray image is different to the penetrating power of different material by X-ray, makes human body glimmering
Image is formed on screen or on film；Above computer tomoscan image abbreviation CT images, be using Accurate collimation X-ray beam,
Gamma-rays, ultrasonic wave etc., the section of a certain position work of human body one by one is together surrounded with the high detector of sensitivity
Scanning, it is fast with sweep time, the features such as image clearly；Above-mentioned positron emission tomography image can provide live body biochemistry and physiology
The medical image of quantitative Diagnosis message；Above-mentioned ultrasonogram seem using the various tissues of human body to the refractions of ultrasonic wave, reflection and
Degree of absorption is different and shows image feature；Above-mentioned nuclear magnetic resonance figures seems by Nmr Lines characteristic parameter, for example
The measure of breadth of spectrum line, line contour shape, spectral line area, position of spectral line etc. analyzes the molecular structure and property of material, tool
There are very high resolving power and accuracy.
Medical image rises emphatically in terms of processing life science, medical diagnosis and clinical treatment, lift face beauty
Act on；The medical image recording various data of existing object, are follow-up three-dimensional modeling and modelling are provided preferably
Data basis.
Further, in order to obtain position physical model to be repaired, the present invention is when implementing, also by portion to be repaired
The data input of the three-dimensional digital model of position prints the physical model at position to be repaired to polyether-ether-ketone 3D printer.Wherein,
Above-mentioned print procedure includes：The data of the three-dimensional digital model at position to be repaired are converted into stereolithography art file；
Stereolithography art file is inputted to polyether-ether-ketone 3D printer, the physical model at position to be repaired is printed.It is above-mentioned
Stereolithography art short title stl file, is a kind of 3-D graphic tray serviced for RP technique
Formula, belongs to a kind of excuse agreement.Stereolithography art file is made up of the definition of multiple triangle surfaces, each triangle
The definition of dough sheet include triangle each fixed point three-dimensional coordinate and triangle surface law vector.
The to be repaired position three higher with existing object matching degree is can print out by above-mentioned polyether-ether-ketone 3D printer
Tie up physical model, and with manufacture difficulty is low, conveniently advantage.
In order to which the skeleton character with existing object is more matched, the material of above-mentioned polyether-ether-ketone 3D printer can include gathering
Ether ether ketone and carbon fiber reinforced polyether-ether-ketone.In the prior art, the phenomenon of stress shielding is the important embodiment of bone remoulding effect,
In bone, Gegenbaur's cell and osteoclast in bone tissue are adjusted by experiencing mechanical stimulation come the growth to bone or absorption
Control.Conventional titanium alloy material has good mechanical strength at present, but its biocompatibility is not good enough, and modulus of elasticity is far above people
Body bone, easily causes stress shielding phenomenon, is unfavorable for bone tissue regeneration after implanting.Polyether-ether-ketone has following features：X-ray
It can penetrate, be easy to observe fracture healing process, with metal phase ratio, postoperative CT and magnetic resonance examination are not required to worry metal artifacts；It is resistance to
Good in thermal property, 334 DEG C of fusing point can the long-term work at a high temperature of 200 DEG C；Chemical property is stable, changes under various physics radiations
Structure is learned not change, it is corrosion-resistant, it is dissolved only in the concentrated sulfuric acid.Therefore, polyether-ether-ketone should be widely used in orbital implant, can be big
Big reduction is due to metal material and skeleton modulus of elasticity gap is excessive and the stress shielding, the bone information that cause, and metal
The problems such as implant causes rejection, second operation.Because the cohesive force of polyether-ether-ketone is strong, it is difficult to bond with other materials,
Situation loosely Nian Jie with bottom plate can be produced, it is necessary to which the poly (ether ether ketone) film of customization is pasted onto into 3D printing system in layering processing
System aluminium alloy base plate top layer；Aluminium alloy base plate can also be replaced with the substrate of other excellent heat conductivity materials.3D printing shower nozzle knot
Structure can be the wire feed structures such as plunger type or spiral squeezing type.
In view of existing conventional repair materials modelling difficulty is big, time-consuming, and with eye bone matching degree compared with
Low the problem of, the embodiments of the invention provide the preparation method of orbital reconstruction material and device, the technology can be using correlation
Software and equipment are realized, are described below by embodiment.
A kind of structural representation of the producing device of orbital reconstruction material shown in Figure 2, the device includes following mould
Block：
Eye bone medical image acquisition module 21, the eye bone medical image number for obtaining existing object
According to；
Image procossing detection module 22, for carrying out image procossing to eye bone medical image, is detected to be repaired
Multiple position；
Data extraction module 23, the texture data for extracting position to be repaired；Wherein, texture data bag
Include：Socket of the eye inwall skeleton data, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, the margo supraorbitalis at position to be repaired
Skeleton data, socket of the eye lower edge skeleton data, socket of the eye inner edge skeleton data and socket of the eye outer rim skeleton data；
Modeling module 24, for being handled using three-dimensional modeling method the texture data at position to be repaired, is obtained
The three-dimensional digital model at position to be repaired；
Print module 25, for by the data input of the three-dimensional digital model at position to be repaired to polyether-ether-ketone 3D printing
Machine, prints the physical model at position to be repaired.
In the said apparatus of the present embodiment, by obtaining the eye bone medical image of existing object, to above-mentioned figure
As data progress processing monitoring and extraction, and carry out three-dimensional modeling and print physical model, can be produced for existing object
The physical model at higher position to be repaired with the orbit bones matching degree of the object, and manufacture difficulty is low, it is convenient and swift.
It should be noted that similar label and letter represent similar terms in following accompanying drawing, therefore, once a certain Xiang Yi
It is defined in individual accompanying drawing, then it further need not be defined and explained in subsequent accompanying drawing.
The technique effect and preceding method embodiment phase of the device that the embodiment of the present invention is provided, its realization principle and generation
Together, to briefly describe, device embodiment part does not refer to part, refers to corresponding contents in preceding method embodiment.
In order to obtain the orbit bones data that existing object is detailed, above-mentioned eye bone medical image obtains mould
Block 21 includes：
X-ray image acquiring unit, the x-ray image of the eye bone for obtaining existing object by X-ray Image-forming instrument；
Computed tomography image acquiring unit, the computer for obtaining existing object by computed tomography scanner breaks
Tomographic image；
Positron faultage image acquiring unit, the positron tomograph for obtaining existing object by positron emission tomography instrument
Picture；
Ultrasound image acquisition unit, the ultrasonoscopy for obtaining existing object by diasonograph；
Nuclear magnetic resonance image acquiring unit, the nuclear magnetic resonance image for obtaining existing object by NMR.
By above-mentioned eye bone medical image acquisition module 21, one or more doctors of existing object can be obtained
Learn view data；The medical image recording various data of existing object, are follow-up three-dimensional modeling and modelling are provided
Preferable data basis.
In order to which the 2-D data extracted from medical image information is converted into threedimensional model, above-mentioned modeling module 24
Including：
Data preparation unit, data preparation processing is carried out for the texture data to position to be repaired；
Processing unit is modeled, for being modeled processing to the data that data preparation unit is exported；
Model lead-out unit, export processing is carried out for the model to modeling processing unit output.
By the processing of above-mentioned modeling module, can quickly and accurately it be obtained according to the medical image of existing object
The threedimensional model at position to be repaired；And the index such as shape, the size of the threedimensional model and the eye bone of above-mentioned existing object
It is higher with degree.
In order to obtain position physical model to be repaired, above-mentioned print module 25 includes：
Date Conversion Unit, for the data of the three-dimensional digital model at position to be repaired to be converted into stereolithography
Art file；
Input block, for stereolithography art file to be inputted to polyether-ether-ketone 3D printer.Polyether-ether-ketone 3D
Print system carries insulation Photocopy Room, and Photocopy Room can add using the heating of stainless steel infrared heating circle or quartz mica are infrared
The modes such as heat carry out thermal field regulation.
The 3D solid that the stl file of artificial bone input self-control polyether-ether-ketone 3D printing system is subjected to artificial bone manufacture into
One step comprises the following steps：
The first step is small with 100 DEG C~140 DEG C of temperature drying 12 by a diameter of 1.6mm polyether-ether-ketone silk drying baker
When；
Second step, T1 (340 DEG C~355 DEG C), aluminium alloy are preheating to by making temperature control system by oneself by 3D printing system shower nozzle
Basal plate preheating is to T2 (110 DEG C~120 DEG C), and Photocopy Room is preheating to T3 (200 DEG C~230 DEG C)；
A diameter of 0.3mm 3D printing nozzle, is adjusted to away from print platform 0.2mm, then by the 3rd step by control system
Double-gear wire feeder at the uniform velocity sends into a diameter of 1.6mm polyether-ether-ketone silk in the shower nozzle having been warmed up, 3D printing system shower nozzle
The artificial bone track generated according to delamination software is advanced, and prints the first layer of polyether-ether-ketone artificial bone, is according to control then
The trajectory path of system planning, prints the 2nd, 3 layer respectively, until completing the 3D printing of bionical polyether-ether-ketone artificial bone；
4th step, in order to mitigate polyether-ether-ketone artificial bone in forming process caused by internal stress, brittle failure, be layered, stick up
The problems such as song deformation, printing room temperature T3 is gradually cooled to room temperature by 200 DEG C~230 DEG C of speed with 5 DEG C -10 DEG C/min,
Then bionical polyether-ether-ketone artificial bone is taken out from Photocopy Room again.
The to be repaired position three higher with existing object matching degree is can print out by above-mentioned polyether-ether-ketone 3D printer
Physical model is tieed up, and with easy to make, efficiently advantage.
The present invention is in practical application, can incite somebody to action wound posterior orbit progress CT scan to be repaired
The layer data that CT scan is obtained is with Dicom (Digital Imaging and Communications in
Medicine, digital imaging and communications in medicine form) output, through Mimics (Materialise's interactive
The interactive medical image control system of medical image control system, Materialise companies) software weight
Its threedimensional model is built, matching personalized eye Trauma is produced, is set according to defect size and stability around it
Sticking patch is counted, 3D printer is output to STL forms, eye socket Cranial defect artificial implantation is printed using polyetheretherketonematerials materials.This
Invention compared with prior art, in art can directly using preoperative printed personalized artificial bone plant replace titanium,
The materials such as Man Tebo, are not required to plasticity in art, trimming, so as to greatly shorten operating time, reduce each in intraoperative hemorrhage, reduction art
Plant the incidence of complication.
Further, the 3D printing manufacture method of the Polyether-ether-ketobiomimetic biomimetic artificial bone comprises the following steps：Patient is obtained to treat
The medical image of implant site, extract from the medical image of acquisition required for bone tissue data, set up imitative
The three-dimensional digital model of artificial bone is given birth to, artificial bone three-dimensional digital model is subjected to format conversion, the file after conversion is inputted into 3D
Print system carries out the three-dimensional manufacture of artificial bone, carries out cell toxicity test, animal experiment, clinical test；Comprise the following steps that：
Step 1: obtaining the medical image at patient position to be implanted using CT, MRI, ultrasonic medical instrument；Step 2: by step
The patient's position medical image input computer to be implanted obtained in one, handles medical image, extracts
Required bone tissue data；Step 3: handling the bone tissue data extracted in step 2, realized using reverse-engineering
Artificial bone three-dimensional digital model is set up；Step 4: the artificial bone 3-dimensional digital mould for being set up step 3 using 3 d modeling software
Type is converted into the STL formatted files that 3D printing system can be recognized；Step 5: making the stl file input of artificial bone by oneself polyethers
Ether ketone 3D printing system carries out the 3D solid manufacture of artificial bone；Step 6: to the polyether-ether-ketone manufactured using 3D printing technique
Biomimetic artificial bone carries out cell toxicity test, and animal experiment finally carries out clinical test.
, can be with several embodiments provided by the present invention, it should be understood that described systems, devices and methods
Realize by another way.Device embodiment described above is only schematical, for example, the division of the unit,
It is only a kind of division of logic function, there can be other dividing mode when actually realizing, in another example, multiple units or component can
To combine or be desirably integrated into another system, or some features can be ignored, or not perform.It is another, it is shown or beg for
The coupling each other of opinion or direct-coupling or communication connection can be by some communication interfaces, device or unit it is indirect
Coupling is communicated to connect, and can be electrical, machinery or other forms.
In addition, each functional unit in each embodiment of the invention can be integrated in a processing unit, can also
That unit is individually physically present, can also two or more units it is integrated in a unit.
Finally it should be noted that：Embodiment described above, is only the embodiment of the present invention, to illustrate the present invention
Technical scheme, rather than its limitations, protection scope of the present invention is not limited thereto, although with reference to the foregoing embodiments to this hair
It is bright to be described in detail, it will be understood by those within the art that：Any one skilled in the art
The invention discloses technical scope in, it can still modify to the technical scheme described in previous embodiment or can be light
Change is readily conceivable that, or equivalent substitution is carried out to which part technical characteristic；And these modifications, change or replacement, do not make
The essence of appropriate technical solution departs from the spirit and scope of technical scheme of the embodiment of the present invention.The protection in the present invention should all be covered
Within the scope of.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (8)
1. a kind of preparation method of orbital reconstruction material, it is characterised in that methods described includes：
Obtain the eye bone medical image of existing object；
Image procossing is carried out to the eye bone medical image, position to be repaired is detected；
Extract the texture data at the position to be repaired；Wherein, the texture data includes：The position to be repaired
Socket of the eye inwall skeleton data, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, margo supraorbitalis skeleton data, under socket of the eye
Edge skeleton data, socket of the eye inner edge skeleton data and socket of the eye outer rim skeleton data；
The texture data at the position to be repaired is handled using three-dimensional modeling method, the position to be repaired is obtained
Three-dimensional digital model；
By the data input of the three-dimensional digital model at the position to be repaired to polyether-ether-ketone 3D printer, print described to be repaired
The physical model at multiple position；
The data input of the three-dimensional digital model by the position to be repaired is printed described to polyether-ether-ketone 3D printer
The physical model at position to be repaired includes：The data of the three-dimensional digital model at the position to be repaired are converted into photocuring three-dimensional
Modeling file；The stereolithography art file is inputted to the polyether-ether-ketone 3D printer, described treat is printed
Repair the physical model at position；
The 3D solid manufacture that the stl file input of artificial bone is carried out into artificial bone from polyether-ether-ketone 3D printing system includes following
Step：
The first step, a diameter of 1.6mm polyether-ether-ketone silk drying baker is dried 12 hours with 100 DEG C~140 DEG C of temperature；
Second step, T1 (340 DEG C~355 DEG C), aluminium alloy base plate are preheating to by making temperature control system by oneself by 3D printing system shower nozzle
T2 (110 DEG C~120 DEG C) is preheating to, Photocopy Room is preheating to T3 (200 DEG C~230 DEG C)；
A diameter of 0.3mm 3D printing nozzle, is adjusted to away from print platform 0.2mm, subsequent bidentate by the 3rd step by control system
Wheel wire feeder at the uniform velocity sends into a diameter of 1.6mm polyether-ether-ketone silk the shower nozzle having been warmed up, 3D printing system shower nozzle according to
The artificial bone track of delamination software generation is advanced, and is printed the first layer of polyether-ether-ketone artificial bone, is then advised according to control system
The trajectory path drawn, prints the 2nd, 3 layer respectively, until completing the 3D printing of bionical polyether-ether-ketone artificial bone；
4th step, is gradually cooled to room temperature, so by printing room temperature T3 by 200 DEG C~230 DEG C of speed with 5 DEG C -10 DEG C/min
Take out bionical polyether-ether-ketone artificial bone from Photocopy Room again afterwards.
2. the preparation method of orbital reconstruction material according to claim 1, it is characterised in that to the eye bone medical science
View data carries out image procossing, detects that position to be repaired includes：
Image enhancement processing, image dividing processing, image conversion process and figure are carried out to the eye bone medical image
As detection process, position to be repaired is detected.
3. the preparation method of orbital reconstruction material according to claim 1, it is characterised in that using three-dimensional modeling method to institute
Stating the texture data progress processing at position to be repaired includes：
Data preparation processing, modeling processing and model export processing are carried out to the texture data at the position to be repaired.
4. the preparation method of orbital reconstruction material according to claim 1, it is characterised in that the eye of the existing object
Bone medical image includes the one or more in data below：X-ray image data, computed tomography images number
According to, positron emission tomography view data, ultrasound image data and nuclear magnetic resonance image data.
5. the preparation method of orbital reconstruction material according to any one of claim 1 to 4, it is characterised in that described poly-
The material of ether ether ketone 3D printer includes：Polyether-ether-ketone and carbon fiber reinforced polyether-ether-ketone.
6. a kind of producing device of orbital reconstruction material, it is characterised in that described device includes：
Eye bone medical image acquisition module, the eye bone medical image for obtaining existing object；
Image procossing detection module, for carrying out image procossing to the eye bone medical image, is detected to be repaired
Position；
Data extraction module, the texture data for extracting the position to be repaired；Wherein, the texture data bag
Include：Socket of the eye inwall skeleton data, socket of the eye outer wall skeleton data, socket of the eye top skeleton data, orbital floor skeleton data, the socket of the eye at the position to be repaired
Upper limb skeleton data, socket of the eye lower edge skeleton data, socket of the eye inner edge skeleton data and socket of the eye outer rim skeleton data；
Modeling module, for being handled using three-dimensional modeling method the texture data at the position to be repaired, obtains institute
State the three-dimensional digital model at position to be repaired；
Print module, for by the data input of the three-dimensional digital model at the position to be repaired to polyether-ether-ketone 3D printer,
Print the physical model at the position to be repaired；
The print module includes：Date Conversion Unit, for the data of the three-dimensional digital model at the position to be repaired to be turned
It is changed to stereolithography art file；Input block, for the stereolithography art file to be inputted to polyethers ether
Ketone 3D printer；
The print module is additionally operable to the stl file input of artificial bone carrying out the three of artificial bone from polyether-ether-ketone 3D printing system
Dimension entity manufacture comprises the following steps：The first step, by a diameter of 1.6mm polyether-ether-ketone silk drying baker with 100 DEG C~140 DEG C
Temperature dry 12 hours；Second step, T1 (340 DEG C~355 is preheating to by making temperature control system by oneself by 3D printing system shower nozzle
DEG C), aluminium alloy base plate is preheating to T2 (110 DEG C~120 DEG C), and Photocopy Room is preheating to T3 (200 DEG C~230 DEG C)；3rd step, passes through
A diameter of 0.3mm 3D printing nozzle is adjusted to away from print platform 0.2mm by control system, and subsequent Double-gear wire feeder is by diameter
The shower nozzle having been warmed up, the people that 3D printing system shower nozzle is generated according to delamination software are at the uniform velocity sent into for 1.6mm polyether-ether-ketone silk
Work bone track is advanced, and prints the first layer of polyether-ether-ketone artificial bone, the trajectory path then planned according to control system, respectively
The 2nd, 3 layer is printed, until completing the 3D printing of bionical polyether-ether-ketone artificial bone；4th step, will printing room temperature T3 by 200 DEG C~
230 DEG C of speed with 5 DEG C -10 DEG C/min is gradually cooled to room temperature, bionical polyether-ether-ketone is then taken out from Photocopy Room again artificial
Bone.
7. the producing device of orbital reconstruction material according to claim 6, it is characterised in that the eye bone medical science figure
As data acquisition module includes：
X-ray image acquiring unit, the x-ray image of the eye bone for obtaining existing object by X-ray Image-forming instrument；
Computed tomography image acquiring unit, the computerized tomography figure for obtaining existing object by computed tomography scanner
Picture；
Positron faultage image acquiring unit, the positron faultage image for obtaining existing object by positron emission tomography instrument；
Ultrasound image acquisition unit, the ultrasonoscopy for obtaining existing object by diasonograph；
Nuclear magnetic resonance image acquiring unit, the nuclear magnetic resonance image for obtaining existing object by NMR.
8. the producing device of orbital reconstruction material according to claim 6, it is characterised in that the modeling module includes：
Data preparation unit, data preparation processing is carried out for the texture data to the position to be repaired；
Processing unit is modeled, for being modeled processing to the data that the data preparation unit is exported；
Model lead-out unit, export processing is carried out for the model to the modeling processing unit output.
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| EP3406225B1 (en) * | 2017-05-23 | 2023-04-26 | HVR Cardio Oy | Annuloplasty implant |
| CN108596877B (en) * | 2018-03-28 | 2022-02-08 | 苏州科技城医院 | Rib CT data analysis system |
| CN111745975A (en) * | 2020-07-01 | 2020-10-09 | 首都医科大学附属北京同仁医院 | Artificial eye piece manufacturing method, artificial eye piece and artificial eye |
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