CN112842626A - 一种3d打印多孔生物陶瓷支架修复系统及其制备方法 - Google Patents
一种3d打印多孔生物陶瓷支架修复系统及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种3D打印多孔生物陶瓷支架修复系统,包括多孔生物陶瓷支架和骨膜,所述多孔生物陶瓷支架包括支架本体和固定桩,所述支架本体和所述固定桩为3D打印一体件;所述骨膜能够覆盖于所述多孔生物陶瓷支架的表面,通过所述固定桩能够将所述多孔生物陶瓷支架植入牙槽骨内;所述多孔生物陶瓷支架具有三维贯通的多孔结构。本发明通过可降解的多孔生物陶瓷支架配合骨膜技术,支撑骨再生的空间,多孔生物陶瓷支架具有三维贯通的多孔结构,促进营养物质的运输和代谢废物的输送;另外,该多孔生物陶瓷支架是由3D打印技术制得的支架,便于实现定制化。
Description
技术领域
本发明涉及口腔医疗器械技术领域,具体涉及一种用于垂直骨增量的3D打印多孔生物陶瓷支架修复系统及其制备方法。
背景技术
随着社会经济的发展以及人们口腔观念的转变,口腔种植修复技术在临床快速普及,用于治疗由外伤、龋病、牙周炎等造成的牙列缺损、牙列缺失,可较好地恢复缺牙区的咀嚼功能。种植区的骨质骨量是影响种植手术成败的关键因素之一。目前,引导骨组织再生技术被广泛用于骨增量术中,对于因牙周炎、牙槽骨吸收等因素导致骨质骨量不足而无法进行种植修复的病例可取得较好的治疗效果。其原理是在骨缺损区域植入骨移植物后,表面覆盖生物屏障膜,从而阻断上皮细胞和成纤维细胞向缺损区域长入,同时为骨组织的生长提供良好的环境。
为了达到更好的骨再生效果,目前大多发明着眼于对骨粉材料进行成骨诱导性能优化,但覆盖于膜下的骨粉无法获得较好的固位能力,在咀嚼力或外力作用下易位移、塌陷,致使骨高度恢复不足;通常金属支撑材料存在“应力遮蔽”现象,不利于新骨生长;在实现骨再生后需进行二次手术取出钛网或帐篷钉,增加手术创伤。
发明内容
本发明主要解决的技术问题是提供一种3D打印多孔生物陶瓷支架修复系统,通过可降解的多孔生物陶瓷支架配合骨膜技术,支撑骨再生的空间,多孔生物陶瓷支架具有三维贯通的多孔结构,促进营养物质的运输和代谢废物的输送;另外,该多孔生物陶瓷支架是由3D打印技术制得的支架,便于实现定制化。
为解决上述技术问题,本发明采用的一个技术方案是:提供一种3D打印多孔生物陶瓷支架修复系统,所述修复系统包括多孔生物陶瓷支架和骨膜,所述多孔生物陶瓷支架包括支架本体和固定桩,所述支架本体和所述固定桩为3D打印一体件;
所述骨膜能够覆盖于所述多孔生物陶瓷支架的表面,通过所述固定桩能够将所述多孔生物陶瓷支架植入牙槽骨内;
所述多孔生物陶瓷支架具有三维贯通的多孔结构。
进一步地说,所述固定桩为圆柱形的支柱。
进一步地说,所述固定桩的长度为3-8mm,且外径为2mm-3.5mm。
进一步地说,所述多孔生物陶瓷支架的多孔结构的孔径为200-700μm。
进一步地说,所述多孔生物陶瓷支架的外形尺寸为:长度为10mm-14mm,高度为3mm-10mm,且厚度为2mm-5mm。
进一步地说,所述多孔生物陶瓷支架为无机生物陶瓷支架。
进一步地说,所述述多孔生物陶瓷支架的孔隙率为5%~80%。
本发明还提供了一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速搅拌0.5-4h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为30-65wt%,氧化物助烧剂的比例为0.5-2wt%;
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为5000~30000ms,分层厚度设置为0.05~0.1mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇中,放置在超声波清洗机中清洗5-30min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下0.5-2h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
进一步地说,S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:50-90wt%、0-25wt%、0.5-7wt%、0-7wt%、0-7wt%和0-4wt%。
进一步地说,S5中,所述脱脂烧结的温度控制如下:以1-3℃/min的升温速率,从25℃升温到120℃,保温2-4h;再以1-3℃/min的升温速率,从120℃升温到200℃,保温2-4h;再以1-3℃/min的升温速率,从200℃升温到440℃,保温2-4h;再以10-15℃/min的升温速率,从440℃升温到1150℃,保温2-4h。
本发明的有益效果是:本发明的至少具有以下优点:
一、本发明的多孔生物陶瓷支架具有三维贯通的多孔结构,可促进营养物质的运输和代谢废物的输送以及骨再生的效果;
二、本发明的修复系统,通过固定桩固定于牙槽骨预先打好的植入窝内,能够获得较好的固位能力,在咀嚼力或外力作用下不会位移、塌陷,具有足够的骨高度恢复力;
三、本发明的多孔生物陶瓷支架为无机生物陶瓷支架,其为可降解材料制备的支架,因此无需二次手术取出,避免二次手术创伤,也会减轻给病人带来的痛苦;
四、采用本发明的多孔生物支架修复系统用于牙齿修复,相比于通过钛网或帐篷钉等植入方法,本发明的生物陶瓷支架可减少“应力遮蔽”现象,利于新骨生长;
五、本发明的多孔生物陶瓷支架为3D打印多孔生物陶瓷支架,操作简单,可以个性化定制。
上述说明仅是本发明技术方案的概述,为了能够更清楚了解本发明的技术手段,并可依照说明书的内容予以实施,以下以本发明的较佳实施例并配合附图详细说明如后。
附图说明
图1为本发明的多孔生物陶瓷支架的结构示意图;
图2为本发明的多孔生物陶瓷支架的安装于牙槽骨后的结构示意图之一(即修复系统在未覆盖骨膜时的使用状态示意图);
图3为本发明的多孔生物陶瓷支架的安装于牙槽骨后的结构示意图之二(即修复系统在覆盖骨膜后的使用状态示意图);
图4为本发明的3D打印多孔生物陶瓷支架修复系统使用过程的流程图;
附图标记说明:
多孔生物陶瓷支架1、支架本体11、固定桩12、骨膜2、牙槽骨3和植入窝31。
具体实施方式
以下通过特定的具体实施例说明本发明的具体实施方式,本领域技术人员可由本说明书所揭示的内容轻易地了解本发明的优点及功效。本发明也可以其它不同的方式予以实施,即,在不背离本发明所揭示的范畴下,能于不同的修饰与改变。
实施例:一种3D打印多孔生物陶瓷支架修复系统100,如图1到4所示,所述修复系统包括多孔生物陶瓷支架1和骨膜2,所述多孔生物陶瓷支架包括支架本体11和固定桩12,所述支架本体和所述固定桩为3D打印一体件;
所述骨膜能够覆盖于所述多孔生物陶瓷支架的表面,通过所述固定桩能够将所述多孔生物陶瓷支架植入牙槽骨3内;本实施例中,多孔生物陶瓷支架1通过其固定桩11安装于牙槽骨设有的植入窝31而固定于牙槽骨3;
所述多孔生物陶瓷支架具有三维贯通的多孔结构。
所述固定桩为圆柱形的支柱。本实施例中,所述固定桩具有两个。
所述固定桩的长度为3-8mm,且外径为2mm-3.5mm。
所述多孔生物陶瓷支架的多孔结构的孔径为200-700μm。
所述多孔生物陶瓷支架的外形尺寸为:长度为10mm-14mm,高度为3mm-10mm,且厚度为2mm-5mm。
较佳的是,所述多孔生物陶瓷支架为无机生物陶瓷支架。
所述述多孔生物陶瓷支架的孔隙率为5%~80%。
一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速搅拌0.5-4h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为30-65wt%,氧化物助烧剂的比例为0.5-2wt%;(添加的氧化物助烧剂具有增强最终的多孔生物支架力学性能的作用)
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为5000~30000ms,分层厚度设置为0.05~0.1mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇(比如75%的乙醇)中,放置在超声波清洗机中清洗5-30min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下0.5-2h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:50-90wt%、0-25wt%、0.5-7wt%、0-7wt%、0-7wt%和0-4wt%。
较佳的是:S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:57-90wt%、0-25wt%、0.5-5wt%、0-5wt%、0-5wt%和0-3wt%。
S5中,所述脱脂烧结的温度控制如下:以1-3℃/min的升温速率,从25℃升温到120℃,保温2-4h;再以1-3℃/min的升温速率,从120℃升温到200℃,保温2-4h;再以1-3℃/min的升温速率,从200℃升温到440℃,保温2-4h;再以10-15℃/min的升温速率,从440℃升温到1150℃,保温2-4h。
优选的,所述S1中所述多官能团树脂单体为聚乙二醇二丙烯酸酯、环氧丙烯酸酯、聚氨酯丙烯酸酯和聚酯丙烯酸酯中的至少一种。
优选的,所述S1中所述活性稀释剂为PEG、HDDA、TPGDA、TMPTA、THFA和TMPTMA中的至少一种。
优选的,所述S1中所述的光引发剂为2,4,6-三甲基苯甲酰基-二苯基氧化膦(TPO)、苯基-2,4,6-三甲基苯甲酰基亚磷酸锂(LAP)、2,4,6-三甲基苯甲酰基膦酸乙酯和二苯基(2,4,6-三甲基苯甲酰基)氧化膦中的至少一种。
优选的,所述S2中所述生物陶瓷粉体为β-磷酸三钙、羟基磷灰石、镁黄长石、生物玻璃、硅酸钙和磷酸镁中的至少一种。
优选的,所述S2中所述氧化物助烧剂为氧化镁、氧化锌、氧化镓和氧化锂中的至少一种。
本实施例中,多孔生物陶瓷支架1优选采用能够降解的无机生物陶瓷材料,例如可选用β-磷酸三钙、羟基磷灰石、镁黄长石、生物玻璃、硅酸钙和磷酸镁中的至少一种,并添加氧化物助烧剂提高力学强度。支架具有可降解特性,可避免二次手术取出。
以下为列举的本发明的几个具体实施例:
实施例1:一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速(比如钻速约为400-700rpm)搅拌0.5h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为30wt%,氧化物助烧剂的比例为2wt%;(添加的氧化物助烧剂具有增强最终的多孔生物支架力学性能的作用)
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为5000ms,分层厚度设置为0.1mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇(比如75%的乙醇)中,放置在超声波清洗机中清洗30min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下0.5h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:50wt%、25wt%、7wt%、7wt%、7wt%和4wt%。
S5中,所述脱脂烧结的温度控制如下:以1℃/min的升温速率,从25℃升温到120℃,保温4h;再以1℃/min的升温速率,从120℃升温到200℃,保温4h;再以1℃/min的升温速率,从200℃升温到440℃,保温4h;再以15℃/min的升温速率,从440℃升温到1150℃,保温4h。
其中,所述S1中所述多官能团树脂单体为聚乙二醇二丙烯酸酯和环氧丙烯酸酯,二者重量比为1:1。
优选的,所述S1中所述活性稀释剂为PEG。
所述S1中所述光引发剂为2,4,6-三甲基苯甲酰基-二苯基氧化膦(TPO)。
所述S2中所述生物陶瓷粉体为β-磷酸三钙和羟基磷灰石,二者重量比为1:1。
所述S2中所述氧化物助烧剂为氧化镁和氧化锌,二者重量比为1:1。
实施例2:一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速搅拌4h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为65wt%,氧化物助烧剂的比例为0.5wt%;(添加的氧化物助烧剂具有增强最终的多孔生物支架力学性能的作用)
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为30000ms,分层厚度设置为0.05mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇(比如75%的乙醇)中,放置在超声波清洗机中清洗5min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下2h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:70wt%、20wt%、3wt%、0wt%、5wt%和2wt%。
S5中,所述脱脂烧结的温度控制如下:以3℃/min的升温速率,从25℃升温到120℃,保温2h;再以3℃/min的升温速率,从120℃升温到200℃,保温2h;再以3℃/min的升温速率,从200℃升温到440℃,保温2h;再以10℃/min的升温速率,从440℃升温到1150℃,保温2h。
其中,所述S1中所述多官能团树脂单体为聚氨酯丙烯酸酯。
所述S1中所述活性稀释剂为PEG和HDDA,二者重量比为2:3。
优选的,所述S1中所述的光引发剂为苯基-2,4,6-三甲基苯甲酰基亚磷酸锂(LAP)。
所述S2中所述生物陶瓷粉体为镁黄长石、生物玻璃和硅酸钙,三者重量比为1:1:1。
所述S2中所述氧化物助烧剂为氧化锌。
实施例3:一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速搅拌1.5h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为40wt%,氧化物助烧剂的比例为1.0wt%;(添加的氧化物助烧剂具有增强最终的多孔生物支架力学性能的作用)
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为10000ms,分层厚度设置为0.07mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇(比如75%的乙醇)中,放置在超声波清洗机中清洗15min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下1h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:80wt%、11.5wt%、0.5wt%、0.5wt%、0wt%和3wt%。
S5中,所述脱脂烧结的温度控制如下:以2℃/min的升温速率,从25℃升温到120℃,保温3h;再以2℃/min的升温速率,从120℃升温到200℃,保温3h;再以2℃/min的升温速率,从200℃升温到440℃,保温3h;再以12.5℃/min的升温速率,从440℃升温到1150℃,保温3h。
其中,所述S1中所述多官能团树脂单体为聚酯丙烯酸酯。
所述S1中所述活性稀释剂为TPGDA和TMPTA,二者重量为1:1。
所述S1中所述的光引发剂为二苯基(2,4,6-三甲基苯甲酰基)氧化膦中的至少一种。
优选的,所述S2中所述生物陶瓷粉体为硅酸钙和磷酸镁,二者重量比为3:2。
所述S2中所述氧化物助烧剂为氧化镓。
实施例4:一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速搅拌2.5h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为50wt%,氧化物助烧剂的比例为1.5wt%;(添加的氧化物助烧剂具有增强最终的多孔生物支架力学性能的作用)
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为20000ms,分层厚度设置为0.08mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇(比如75%的乙醇)中,放置在超声波清洗机中清洗25min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下1.5h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:90wt%、0wt%、4wt%、3wt%、3wt%和0wt%。
S5中,所述脱脂烧结的温度控制如下:以1.5℃/min的升温速率,从25℃升温到120℃,保温2.5h;再以1.5℃/min的升温速率,从120℃升温到200℃,保温3.5h;再以2.5℃/min的升温速率,从200℃升温到440℃,保温2.5h;再以13℃/min的升温速率,从440℃升温到1150℃,保温3.5h。
其中,所述S1中所述多官能团树脂单体为环氧丙烯酸酯、聚氨酯丙烯酸酯和聚酯丙烯酸酯,三者重量比为2:1:3。
所述S1中所述活性稀释剂为TMPTA、THFA和TMPTMA,三者重量比为2:1:1。
所述S1中所述的光引发剂为2,4,6-三甲基苯甲酰基膦酸乙酯和二苯基(2,4,6-三甲基苯甲酰基)氧化膦,二者重量比为2:1。
所述S2中所述生物陶瓷粉体为β-磷酸三钙。
所述S2中所述氧化物助烧剂为氧化锂。
实施例5:一种所述的3D打印多孔生物陶瓷支架修复系统的制备方法,于实施例4类似,不同之处在于:
S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:57wt%、25wt%、5wt%、5wt%、5wt%和3wt%。
上述实施例中制备的用于垂直骨增量的3D打印多孔生物陶瓷支架修复系统的使用过程的步骤依次为:植入多空生物陶瓷支架,插入支柱固定后,覆盖骨膜,分离松解黏膜组织,充分减张后拉拢缝合牙龈,请参阅图4,具体步骤如下:
S1:依次使用先锋钻(钻速约为800rpm)及扩孔钻(钻速约为600rpm),获得与固定桩直径及长度相同的植入窝31;
步骤二:将制备好的3D打印多孔生物陶瓷支架两端的固定桩插入植入窝;
步骤三:多孔生物陶瓷支架固定后,表面覆盖骨膜,形成利于骨再生的空间。
综上所述,本发明的用于骨垂直增量的生物陶瓷支架修复系统,可直接固位于牙槽骨,配合使用,实现垂直骨增量,由于其采用可降解材料,可避免二次手术取出,减少病人痛苦和取出时的麻烦等。
以上所述仅为本发明的实施例,并非因此限制本发明的专利范围,凡是利用本发明说明书及附图内容所作的等效结构,或直接或间接运用在其他相关的技术领域,均同理包括在本发明的专利保护范围内。
Claims (10)
1.一种3D打印多孔生物陶瓷支架修复系统,其特征在于:所述修复系统包括多孔生物陶瓷支架和骨膜,所述多孔生物陶瓷支架包括支架本体和固定桩,所述支架本体和所述固定桩为3D打印一体件;
所述骨膜能够覆盖于所述多孔生物陶瓷支架的表面,通过所述固定桩能够将所述多孔生物陶瓷支架植入牙槽骨内;
所述多孔生物陶瓷支架具有三维贯通的多孔结构。
2.根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统,其特征在于:所述固定桩为圆柱形的支柱。
3.根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统,其特征在于:所述固定桩的长度为3-8mm,且外径为2mm-3.5mm。
4.根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统,其特征在于:所述多孔生物陶瓷支架的多孔结构的孔径为200-700μm。
5.根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统,其特征在于:所述多孔生物陶瓷支架的外形尺寸为:长度为10mm-14mm,高度为3mm-10mm,且厚度为2mm-5mm。
6.根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统,其特征在于:所述多孔生物陶瓷支架为无机生物陶瓷支架。
7.根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统,其特征在于:所述述多孔生物陶瓷支架的孔隙率为5%~80%。
8.一种根据权利要求1所述的3D打印多孔生物陶瓷支架修复系统的制备方法,其特征在于:
所述制备方法具体包括如下步骤:
S1、光敏树脂预混液的制备:
将多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂按一定配比,中速搅拌0.5-4h,使上述各组分充分混合均匀,制备得到光敏树脂预混液;
S2、光固化陶瓷浆料的制备:
将生物陶瓷粉体与光敏树脂预混液混合,并加入氧化物助烧剂形成混合物,将该混合物置于球磨机中,以制备出用于光固化成型的光固化陶瓷浆料;
其中,所述混合物中的生物陶瓷粉体的比例为30-65wt%,氧化物助烧剂的比例为0.5-2wt%;
S3、光固化打印过程:
将S2制备好的光固化陶瓷浆料倒入打印机料槽中,将设计好的多孔生物陶瓷支架结构的CAD模型导入陶瓷打印机中,曝光时间设置为5000~30000ms,分层厚度设置为0.05~0.1mm,逐层打印直到打印到末层,打印结束,即得到多孔生物陶瓷支架素坯;
S4、多孔生物陶瓷支架素坯后处理:
将多孔生物陶瓷支架素坯置于乙醇中,放置在超声波清洗机中清洗5-30min,去除多孔生物陶瓷支架素坯表面和孔隙中未固化的光固化陶瓷浆料,洗净后,置于紫外灯下0.5-2h进行后固化处理;
S5、脱脂烧结:
将S4中的固化处理后的陶瓷素坯置于马弗炉中进行脱脂烧结,之后随炉冷却,即得的所述的多孔生物陶瓷支架。
9.根据权利要求8所述的3D打印多孔生物陶瓷支架修复系统的制备方法,其特征在于:S1中的多官能团树脂单体、活性稀释剂、光引发剂、分散剂、光吸收剂和消泡剂中各成分的质量分数为:50-90wt%、0-25wt%、0.5-7wt%、0-7wt%、0-7wt%和0-4wt%。
10.根据权利要求8所述的3D打印多孔生物陶瓷支架修复系统的制备方法,其特征在于:S5中,所述脱脂烧结的温度控制如下:以1-3℃/min的升温速率,从25℃升温到120℃,保温2-4h;再以1-3℃/min的升温速率,从120℃升温到200℃,保温2-4h;再以1-3℃/min的升温速率,从200℃升温到440℃,保温2-4h;再以10-15℃/min的升温速率,从440℃升温到1150℃,保温2-4h。
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CN113662693A (zh) * | 2021-09-15 | 2021-11-19 | 赵正伟 | 基于3d打印的牙槽骨内骨外种植修复桥架 |
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