CN112826878A - Formula of crocus sativus skin-care and mucous membrane-protecting product and preparation method thereof - Google Patents
Formula of crocus sativus skin-care and mucous membrane-protecting product and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a formula of a crocus sativus skin-care and mucous membrane-protecting product and a preparation method thereof, wherein the crocus sativus skin-care and mucous membrane-protecting product comprises the following raw materials: 1-3g of crocus sativus, 3-5g of dextrin, 45-55mL of butanediol, 45-55mL of propanediol, 900-1100mL of inorganic solvent and 30-70mL of organic solvent. The manufacturing method comprises the following steps: 1) accurately weighing crocus sativus and dextrin, and measuring butanediol, propylene glycol, an inorganic solvent and an organic solvent; 2) placing crocus sativus into an ultrasonic oscillator for oscillation; 3) mixing the above materials, and placing in a water bath tank for hot water bath; 4) filtering with 800 mesh filter, and fixing volume; 5) measuring the content of effective components and correcting color; 6) performing storage pretreatment or packaging. The invention has the advantages that: the preparation process is simple, the effective components of the target are accurately extracted, the effective components can be quickly absorbed by contacting skin or mucous membrane tissues without leaving traces, extremely fine capillary vessels are expanded, metabolism is promoted, pigment spots are lightened, and the preparation method has good popularization prospect and market value.
Description
Technical Field
The invention relates to a formula of a crocus sativus skin-care and mucous membrane-protecting product and a preparation method thereof.
Background
Crocus sativus (also known as saffron, saffron) is used as a holy medicine for activating blood circulation, removing blood stasis, whitening skin, cooling blood, detoxifying, removing scars, resolving depression, calming nerves, relieving unsmooth menstruation, postpartum stasis and the like, is brewed, chewed and poorly absorbed at present, and a filament material object cannot be used for skin and contact mucous membrane.
Disclosure of Invention
The invention aims to provide a formula of a crocus sativus skin-care and mucous membrane-protecting product and a preparation method thereof, and aims to solve the problems in the background art.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 1-3g of crocus sativus, 3-5g of dextrin, 45-55mL of butanediol, 45-55mL of propanediol, 900-1100mL of inorganic solvent and 30-70mL of organic solvent.
As a preferred scheme, the formula of the crocus sativus skin-care and mucosa-protection product comprises the following raw materials: 1g of crocus sativus, 5g of dextrin, 45mL of butanediol, 55mL of propylene glycol, 900mL of inorganic solvent and 30-70mL of organic solvent.
As a preferred scheme, the formula of the crocus sativus skin-care and mucosa-protection product comprises the following raw materials: 3g of crocus sativus, 3g of dextrin, 55mL of butanediol, 45mL of propylene glycol, 1100mL of inorganic solvent and 30-70mL of organic solvent.
As a preferred scheme, the formula of the crocus sativus skin-care and mucosa-protection product comprises the following raw materials: 2g of crocus sativus, 4g of dextrin, 50mL of butanediol, 50mL of propanediol, 1000mL of inorganic solvent and 30-70mL of organic solvent.
Preferably, the organic solvent is ethanol.
Preferably, the inorganic solvent is deionized water.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, and measuring butanediol, propylene glycol, an inorganic solvent and an organic solvent as a dissolving agent for assisting dissolution;
2) placing crocus sativus into an ultrasonic oscillator for oscillation;
3) mixing the above materials, and placing in a water bath tank for hot water bath;
4) filtering with 800 mesh filter, and fixing volume;
5) measuring the content of effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition; the final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
The invention has the advantages that: the formula and the preparation method of the crocus sativus skin-care and mucous membrane protection article are provided, the preparation process is simple, the effective components of a target object are accurately extracted, the crocus sativus skin-care and mucous membrane protection article can be quickly absorbed by contacting skin or mucous membrane tissues immediately, no trace is left, extremely fine capillary vessels are expanded, metabolism is promoted, pigment spots are reduced, the skin is ruddy, fair and tender, and the crocus sativus skin-care and mucous membrane protection article has good popularization prospect and market value.
Detailed Description
The invention is illustrated below by means of specific examples, without being restricted thereto.
Example 1
A formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 1g of crocus sativus, 10g of dextrin, 55mL of butanediol, 45mL of propanediol and 1000mL of water, and 30-70mL of ethanol or other organic solvents are added as a dissolving agent for assisting dissolution according to the dissolution degree.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, weighing butanediol, propylene glycol and an inorganic solvent, and adding appropriate ethanol or any other organic solvent which can be used as a dissolving agent to assist dissolution according to the dissolution degree of the crocus sativus in liquid;
2) placing crocus sativus into an ultrasonic oscillator to be vibrated and crushed for 10-90 minutes or crushing by other available crushing methods;
3) mixing the above materials and heating in a water bath or any known heating method at a temperature of 30-95 deg.C for at least 1 hr or more;
4) filtering with 800 mesh filter, and fixing volume;
5) and finally, measuring the content of the effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition. The final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
In a preferred embodiment of this embodiment, the organic solvent is ethanol, and the inorganic solvent is deionized water.
Example 2
A formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 2g of crocus sativus, 20g of dextrin, 55mL of butanediol, 45mL of propanediol and 1000mL of water are measured, and 30-70mL of ethanol or other organic solvents are added as a dissolving agent for assisting dissolution according to the dissolution degree.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, weighing butanediol, propylene glycol and an inorganic solvent, and adding appropriate ethanol or any other organic solvent which can be used as a dissolving agent to assist dissolution according to the dissolution degree of the crocus sativus in liquid;
2) placing crocus sativus into an ultrasonic oscillator to be vibrated and crushed for 10-90 minutes or crushing by other available crushing methods;
3) mixing the above materials and heating in a water bath or any known heating method at a temperature of 30-95 deg.C for at least 1 hr or more;
4) filtering with 800 mesh filter, and fixing volume;
5) and finally, measuring the content of the effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition. The final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
In a preferred embodiment of this embodiment, the organic solvent is ethanol, and the inorganic solvent is deionized water.
Example 3
A formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 3g of crocus sativus, 30g of dextrin, 55mL of butanediol, 45mL of propanediol and 1000mL of water, and 30-70mL of ethanol or other organic solvents are added as a dissolving agent for assisting dissolution according to the dissolution degree.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, weighing butanediol, propylene glycol and an inorganic solvent, and adding appropriate ethanol or any other organic solvent which can be used as a dissolving agent to assist dissolution according to the dissolution degree of the crocus sativus in liquid;
2) placing crocus sativus into an ultrasonic oscillator to be vibrated and crushed for 10-90 minutes or crushing by other available crushing methods;
3) mixing the above materials and heating in a water bath or any known heating method at a temperature of 30-95 deg.C for at least 1 hr or more;
4) filtering with 800 mesh filter, and fixing volume;
5) and finally, measuring the content of the effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition. The final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
In a preferred embodiment of this embodiment, the organic solvent is ethanol, and the inorganic solvent is deionized water.
Example 4
A formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 4g of crocus sativus, 40g of dextrin, 55mL of butanediol, 45mL of propanediol and 1000mL of water, and 30-70mL of ethanol or other organic solvents are added as a dissolving agent for assisting dissolution according to the dissolution degree.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, weighing butanediol, propylene glycol and an inorganic solvent, and adding appropriate ethanol or any other organic solvent which can be used as a dissolving agent to assist dissolution according to the dissolution degree of the crocus sativus in liquid;
2) placing crocus sativus into an ultrasonic oscillator to be vibrated and crushed for 10-90 minutes or crushing by other available crushing methods;
3) mixing the above materials and heating in a water bath or any known heating method at a temperature of 30-95 deg.C for at least 1 hr or more;
4) filtering with 800 mesh filter, and fixing volume;
5) and finally, measuring the content of the effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition. The final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
In a preferred embodiment of this embodiment, the organic solvent is ethanol, and the inorganic solvent is deionized water.
Example 5
A formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 5g of crocus sativus, 50g of dextrin, 55mL of butanediol, 45mL of propanediol and 1000mL of water, and 30-70mL of ethanol or other organic solvents are added as a dissolving agent for assisting dissolution according to the dissolution degree.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, weighing butanediol, propylene glycol and an inorganic solvent, and adding appropriate ethanol or any other organic solvent which can be used as a dissolving agent to assist dissolution according to the dissolution degree of the crocus sativus in liquid;
2) placing crocus sativus into an ultrasonic oscillator to be vibrated and crushed for 10-90 minutes or crushing by other available crushing methods;
3) mixing the above materials and heating in a water bath or any known heating method at a temperature of 30-95 deg.C for at least 1 hr or more;
4) filtering with 800 mesh filter, and fixing volume;
5) and finally, measuring the content of the effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition. The final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
In a preferred embodiment of this embodiment, the organic solvent is ethanol, and the inorganic solvent is deionized water.
Example 6
A formula of a skin-care and mucosa-protection product containing crocus sativus comprises the following raw materials: 6g of crocus sativus, 60g of dextrin, 55mL of butanediol, 45mL of propanediol and 1000mL of water, and 30-70mL of ethanol or other organic solvents are added as a dissolving agent for assisting dissolution according to the dissolution degree.
The preparation method of the formula of the crocus sativus skin-care and mucosa-protection product comprises the following steps:
1) accurately weighing crocus sativus and dextrin, weighing butanediol, propylene glycol and an inorganic solvent, and adding appropriate ethanol or any other organic solvent which can be used as a dissolving agent to assist dissolution according to the dissolution degree of the crocus sativus in liquid;
2) placing crocus sativus into an ultrasonic oscillator to be vibrated and crushed for 10-90 minutes or crushing by other available crushing methods;
3) mixing the above materials and heating in a water bath or any known heating method at a temperature of 30-95 deg.C for at least 1 hr or more;
4) filtering with 800 mesh filter, and fixing volume;
5) and finally, measuring the content of the effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition. The final product prepared by the invention is characterized by containing active ingredients such as safranal, saffron total glycoside, amygdalin, kaempferol, flavonoid compound and the like, wherein the active ingredients in the product are measured by an ultraviolet-visible spectrophotometer according to an ISO/TS3632:2003 method or Chinese pharmacopoeia 2010 version and adopting a 1CM wide ratio color cell, and the active ingredients have reaction display in wavelength ranges of 200-300NM, 300-400NM and 400-500NM, particularly have obvious reaction display at wavelengths of 257NM-297NM, 330NM and 440 NM. The final product made according to the invention contains one or more of the following compounds, compound picrocin, molecular weight about 330, compound picrocin acid, molecular weight about 346, compound diglycoside of picrocin aglycone, molecular weight about 492, compound safranal, molecular weight about 150, compound diglycoside of kaempferol, molecular weight about 610, compound trans-5-nG, molecular weight about 1138, compound trans-4-GG, molecular weight about 976, trans-3-GG, molecular weight about 814, compound trans-2-GG, molecular weight about 652, compound trans-2-G, molecular weight about 652, compound trans-1-G, molecular weight about 490;
6) performing storage pretreatment or packaging.
In a preferred embodiment of this embodiment, the organic solvent is ethanol, and the inorganic solvent is deionized water.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. The formula of the crocus sativus skin-care and mucosa-protection product is characterized by comprising the following raw materials: 1-3g of crocus sativus, 3-5g of dextrin, 45-55mL of butanediol, 45-55mL of propanediol, 900-1100mL of inorganic solvent and 30-70mL of organic solvent.
2. The formula of the crocus sativus skin-care and mucous membrane-protecting product according to claim 1, which is characterized by comprising the following raw materials: 1g of crocus sativus, 5g of dextrin, 45mL of butanediol, 55mL of propylene glycol, 900mL of inorganic solvent and 30-70mL of organic solvent.
3. The formula of the crocus sativus skin-care and mucous membrane-protecting product according to claim 1, which is characterized by comprising the following raw materials: 3g of crocus sativus, 3g of dextrin, 55mL of butanediol, 45mL of propylene glycol, 1100mL of inorganic solvent and 30-70mL of organic solvent.
4. The formula of the crocus sativus skin-care and mucous membrane-protecting product according to claim 1, which is characterized by comprising the following raw materials: 2g of crocus sativus, 4g of dextrin, 50mL of butanediol, 50mL of propanediol, 1000mL of inorganic solvent and 30-70mL of organic solvent.
5. The formula of a skin and mucous membrane protecting product of saffron according to any one of claims 1 to 4, wherein the organic solvent is ethanol.
6. The formula of a crocus sativus skin and mucous membrane protecting product according to any one of claims 1 to 4, wherein the inorganic solvent is deionized water.
7. The method for preparing the formula of the crocus sativus skin-care and mucosa-protection product according to claim 1, which is characterized by comprising the following steps of:
1) accurately weighing crocus sativus and dextrin, and measuring butanediol, propylene glycol, an inorganic solvent and an organic solvent;
2) placing crocus sativus into an ultrasonic oscillator for oscillation;
3) mixing the above materials, and placing in a water bath tank for hot water bath;
4) filtering with 800 mesh filter, and fixing volume;
5) measuring the content of effective components and correcting the color by using an ultraviolet-visible spectrophotometer method according to an ISO/TS3632:2003 method or an HPLC liquid chromatography method according to Chinese pharmacopoeia 2010 edition;
6) performing storage pretreatment or packaging.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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