CN112774807B - Preparation method of palm oil fatty acid magnesium - Google Patents
Preparation method of palm oil fatty acid magnesium Download PDFInfo
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- CN112774807B CN112774807B CN202011614023.3A CN202011614023A CN112774807B CN 112774807 B CN112774807 B CN 112774807B CN 202011614023 A CN202011614023 A CN 202011614023A CN 112774807 B CN112774807 B CN 112774807B
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- 235000019482 Palm oil Nutrition 0.000 title claims abstract description 32
- 239000002540 palm oil Substances 0.000 title claims abstract description 32
- 235000014113 dietary fatty acids Nutrition 0.000 title claims abstract description 19
- 239000000194 fatty acid Substances 0.000 title claims abstract description 19
- 229930195729 fatty acid Natural products 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 239000011777 magnesium Substances 0.000 title claims abstract description 17
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 17
- 150000004665 fatty acids Chemical class 0.000 title claims abstract description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims abstract description 11
- 239000000347 magnesium hydroxide Substances 0.000 claims abstract description 11
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims abstract description 11
- 229940037627 magnesium lauryl sulfate Drugs 0.000 claims abstract description 11
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 11
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 11
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 claims abstract description 11
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- 238000004821 distillation Methods 0.000 claims abstract description 6
- 238000001704 evaporation Methods 0.000 claims abstract description 6
- 239000000706 filtrate Substances 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 238000004537 pulping Methods 0.000 claims abstract description 6
- 238000010992 reflux Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 229960004424 carbon dioxide Drugs 0.000 claims abstract description 3
- 229910002090 carbon oxide Inorganic materials 0.000 claims abstract description 3
- 238000004140 cleaning Methods 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 8
- 229940063002 magnesium palmitate Drugs 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 5
- -1 fatty acid salt Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000000712 assembly Effects 0.000 claims description 3
- 238000000429 assembly Methods 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- ABSWXCXMXIZDSN-UHFFFAOYSA-L magnesium;hexadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O ABSWXCXMXIZDSN-UHFFFAOYSA-L 0.000 claims description 3
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 20
- 235000019359 magnesium stearate Nutrition 0.000 description 10
- 239000000843 powder Substances 0.000 description 7
- 235000011121 sodium hydroxide Nutrition 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005381 potential energy Methods 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B1/00—Cleaning by methods involving the use of tools
- B08B1/10—Cleaning by methods involving the use of tools characterised by the type of cleaning tool
- B08B1/12—Brushes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B1/00—Cleaning by methods involving the use of tools
- B08B1/20—Cleaning of moving articles, e.g. of moving webs or of objects on a conveyor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/74—Recovery of fats, fatty oils, fatty acids or other fatty substances, e.g. lanolin or waxes
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crushing And Pulverization Processes (AREA)
Abstract
The invention provides a preparation method of palm oil fatty acid magnesium, which comprises the following steps: step one, adding 90% ethanol solution of palm oil, magnesium oxide, magnesium hydroxide, magnesium lauryl sulfate and hydrogen peroxide dropwise, and dispersing for 2 hours through strong pulping; step two, adding natural active carbon and sodium hydroxide, heating to a reflux state and keeping for 2-4 hours; step three, controlling the temperature at 40-50 ℃, and carrying out reduced pressure distillation to remove ethanol and water; step four, maintaining the vacuum degree of-0.005 to-0.01 Mpa, raising the temperature to 100 ℃ and 120 ℃, and maintaining for 1 to 1.5 hours; and step five, adding deionized water, stirring, filtering while hot, and evaporating the filtrate to dryness.
Description
Technical Field
The invention belongs to the technical field of biological medicine preparation, and particularly relates to a preparation method of palm oil fatty acid magnesium.
Background
Magnesium Stearate (Magnesium Stearate), a widely used additive in health care products, is generally manufactured from hydrogenated vegetable fats and may hinder absorption of nutrients and immune-related and possibly other toxic effects. Magnesium stearate is commonly used as a film coat for pharmaceutical tablets and, in addition to its lubricating effect, helps to release the active ingredient of the drug at the precise time as required, but excessive intake of magnesium stearate can also lead to some side effects. Magnesium palm oil fatty acid has better effect, but the saponification rate and the purity of the final product are not satisfactory by the conventional method, so that a large amount of palm oil is wasted. Magnesium stearate is needed to be crushed before being added into a medicine in the production process, but magnesium stearate materials can rub with blades in the crushing process, so that magnesium stearate powder is adhered to the surface of a crushing cutter at high temperature, if the magnesium stearate powder is not cleaned in time, after the magnesium stearate powder is cooled, the magnesium stearate powder which is adhered to the crushing cutter and is not cleaned in time can be condensed on a crushing cutter surface and a blade after absorbing moisture in ambient air, the sharpness of the crushing cutter is reduced, and the crushing effect is reduced.
Disclosure of Invention
Aiming at the problems, the invention provides a preparation method of palm oil fatty acid magnesium, which aims to solve the technical problems.
A method for preparing magnesium palmitate comprises a seat plate, a pulverizer housing, a motor and a discharge pipe; the preparation equipment further comprises a blade cleaning assembly and a mounting assembly; the upper surfaces of the seat plates are fixedly connected with a crusher shell, and one side of the crusher shell is fixedly connected with a horizontally arranged motor; the lower end of the crusher shell is fixedly connected with a discharge pipe, and the discharge pipe penetrates through the seat plate;
the upper end of the crusher shell is fixedly connected with a blade cleaning assembly; the blade cleaning assembly comprises a handle, a pair of guide sleeves, a pair of springs, a pair of movable rods and a blade cleaning brush, the guide sleeves are fixedly connected to the top end of the outer side surface of the crusher shell through a connecting plate and a bolt, and the pair of guide sleeves are perpendicular to the crusher shell; the guide sleeves are respectively positioned at the left side and the right side of the crusher shell, and the crushing blade positioned in the crusher shell is positioned right below the area between the guide sleeves; two ends of the handle are respectively and fixedly connected with a connecting sleeve, the connecting sleeves are sleeved at the top end of the movable rod and are fixedly connected to the movable rod through bolts, and the movable rod is perpendicular to the handle; the bottom ends of the movable rods penetrate through a guide sleeve and then are fixedly connected with a first mounting plate, and the first mounting plate and the crusher shell are fixedly connected with the upper surface of a blade cleaning brush positioned in the crusher shell through a mounting assembly; the inner wall of the guide sleeve is fixedly connected with a plurality of balls; the ball is in close contact with the outer side face of the movable rod, and the movable rod can freely slide in the vertical direction along the guide sleeve;
a first spring is sleeved on the pair of movable rods; the top end of the first spring is tightly propped against the inner side surface of the shell of the pulverizer; the bottom end of the first spring is tightly abutted to the upper surface of the blade cleaning brush; when the first spring is in a natural length, the blade cleaning brush is far away from the crushing blade; when the movable rod is completely immersed into the guide sleeve, the first spring is in a compressed state, and the brush part of the blade cleaning brush is in contact with the crushing blade;
the mounting plate I is provided with a through hole which is in the same shape as the limiting plate and vertically penetrates through the mounting plate I, the upper surface of the mounting plate I is also provided with a limiting groove, and the limiting groove is intersected with the through hole; the mounting assembly comprises a fixing sleeve, a torsion bar, a knob and a limiting plate, the bottom end of the fixing sleeve is fixedly connected to the upper surface of the blade cleaning brush through a mounting plate II, and the fixing sleeve is perpendicular to the blade cleaning brush; an annular baffle I is fixedly connected to the inner side wall of the top end of the fixed sleeve; the bottom end of the torsion bar is fixedly connected with a second annular baffle, the top end of the torsion bar penetrates through the fixing sleeve from the bottom end of the fixing sleeve, and the bottom end of the torsion bar is positioned in the fixing sleeve; the torsion bar can freely rotate around the fixing sleeve by 360 degrees and can freely slide along the vertical direction of the fixing sleeve, the torsion bar is prevented from falling out of the fixing sleeve by the clamping of the first annular baffle plate through the second annular baffle plate, and the outer side wall of the second annular baffle plate is tightly contacted with the inner side wall of the fixing sleeve; a second spring is sleeved on the torsion bar and located inside the fixing sleeve, one end of the second spring abuts against the upper surface of the second annular baffle, and the other end of the second spring abuts against the lower surface of the first annular baffle; the second spring is a compression spring, and the central lines of the fixed sleeve, the torsion bar, the first annular baffle plate, the second annular baffle plate and the second spring are superposed;
the top end of the torsion bar is fixedly connected to the lower surface of the limiting plate, the central position of the upper surface of the limiting plate is fixedly connected with a connecting column, and the top end of the connecting column is fixedly connected with a knob handle; the lower end of the knob handle is fixedly sleeved on the connecting column through a connecting sleeve and a bolt, and the center lines of the limiting plate and the torsion bar are overlapped.
As a preferred technical solution, the first mounting plate is provided with a pair of mounting assemblies in a matching manner.
As an optimal technical scheme, after the knob handle and the limiting plate penetrate through the through hole, the knob handle is released when the limiting plate is rotated to be positioned right above the limiting groove, and the limiting plate is tightly clamped in the limiting groove under the stretching action of the second spring.
A preparation method of palm oil fatty acid magnesium comprises the following steps:
step one, adding 90% ethanol solution of palm oil, magnesium oxide, magnesium hydroxide, magnesium lauryl sulfate and hydrogen peroxide dropwise, and dispersing for 2 hours through strong pulping;
step two, adding natural active carbon and sodium hydroxide, heating to a reflux state and keeping for 2-4 hours;
step three, controlling the temperature at 40-50 ℃, and carrying out reduced pressure distillation to remove ethanol and water;
step four, maintaining the vacuum degree of-0.005 to-0.01 Mpa, raising the temperature to 100 ℃ and 120 ℃, and maintaining for 1 to 1.5 hours;
and step five, adding deionized water, stirring, filtering while hot, and evaporating the filtrate to dryness.
As a preferable technical scheme, the mass ratio of the magnesium oxide to the magnesium hydroxide to the magnesium lauryl sulfate in the first step is 10:20: 1-3.
As a preferable technical scheme, in the step one, the mass ratio of the palm oil, the magnesium oxide, the magnesium hydroxide and the magnesium lauryl sulfate to the 90% ethanol solution is 200: 10:20:1-3:400.
As a preferable technical scheme, the adding amount of the hydrogen peroxide in the step one is 1% of that of the palm oil.
As a preferable technical scheme, the adding mass of the natural activated carbon in the second step is 1% of that of the palm oil, and the adding mass of the sodium hydroxide is 5% of that of the palm oil.
As a preferable technical scheme, the addition amount of the deionized water in the fifth step is 5 times of that of the palm oil.
The application of the palm oil fatty acid magnesium is used as a medicinal auxiliary agent or an auxiliary material.
Compared with the prior art, the invention has the advantages that:
1. according to the invention, the blade cleaning assembly is fixedly connected to the shell of the crusher, wherein the blade cleaning brush can clean powder attached to the surface of the blade; wherein, the handle is kept away from or is close to crushing blade through the drive movable rod, and the movable rod drives blade cleaning brush and keeps away from or is close to crushing blade. The motor is turned off, when the brush part of the blade cleaning brush is contacted with the crushing blade, the residual rotation potential energy of the crushing blade can keep rotating slowly, and at the moment, the blade cleaning brush can completely clean the powder attached to the crushing blade; the ball is arranged in the guide sleeve, and rolling friction is formed between the movable rod and the ball, so that the friction resistance between the movable rod and the guide sleeve can be effectively reduced, and the friction loss between the movable rod and the guide sleeve can be reduced; the spring is sleeved in the area, located inside the crusher shell, of the movable rod, one end of the spring is tightly abutted to the inner wall of the crusher shell, the other end of the spring is tightly abutted to the upper surface of the blade cleaning brush, when pressure is not applied to the handle, the brush part of the blade cleaning brush is automatically away from the crushing blade under the action of the spring I, and the situation that the blade cleaning brush is crushed by the crushing blade due to the fact that an operator forgets to restore the blade cleaning brush to the original position is avoided.
2. According to the invention, the mounting assembly is arranged between the movable rod and the blade cleaning brush, the fixed sleeve, the torsion bar, the knob handle and the limiting plate are arranged on the mounting assembly, the torsion bar is pulled upwards, the distance between the limiting plate and the upper surface of the first mounting plate can be increased, the limiting plate is higher than the upper surface of the first mounting plate, the knob handle can be conveniently rotated until the limiting plate is positioned right above the limiting groove, the limiting plate is released to be clamped in the limiting groove, the movable rod and the blade cleaning brush can be detachably and fixedly connected, and the blade cleaning brush can be conveniently replaced and mounted; further, through increasing spring two between fixed cover and torsion bar, after the release button handle, the limiting plate tightly blocks all the time in the spacing inslot under the resilience force effect of spring two, can ensure the stable connection between blade cleaning brush and the movable rod.
3. According to the invention, through reasonable selection of raw materials, the magnesium oxide, the magnesium hydroxide and the magnesium lauryl sulfate are used as composite magnesium sources, the activated carbon and the caustic soda flakes are used as catalysts, the reaction is promoted, the use amount of a large amount of caustic soda flakes is reduced, and the conversion rate is improved. In addition, the invention adopts the combination of normal pressure reaction and reduced pressure reaction, and can effectively improve the conversion rate of the reaction.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of a first perspective structure of the present invention;
FIG. 2 is a schematic view of a second perspective structure of the present invention;
FIG. 3 is a schematic view of a third perspective structure of the present invention;
FIG. 4 is a schematic view of the blade cleaning assembly and shredder housing connection of the present invention;
FIG. 5 is a schematic view of a blade cleaning assembly according to the present invention;
FIG. 6 is an enlarged view of the structure at A in FIG. 5;
FIG. 7 is a schematic view of a connection structure of a guide sleeve and a ball;
FIG. 8 is a schematic view of a mounting plate according to the present invention;
FIG. 9 is a schematic view of the mounting assembly of the present invention;
FIG. 10 is a schematic view of an installation structure of a torsion bar, a fixing sleeve, a first ring-shaped limiting plate and a second ring-shaped limiting plate according to the present invention;
FIG. 11 is a schematic view of an installation structure of a second spring, a torsion bar, a fixing sleeve, a first ring-shaped limiting plate and a second ring-shaped limiting plate according to the present invention.
The device comprises a base plate 1, a pulverizer 2, a motor 3, a discharge pipe 4, a blade cleaning component 5, a handle 501, a guide sleeve 502, a spring I503, a movable rod 504, a blade cleaning brush 505, a connecting sleeve 506, a mounting plate I507, a ball 508, a mounting component 6, a fixing sleeve 601, a torsion bar 602, a torsion bar 603, a button handle 604, a limiting plate 605, a mounting plate II 605, an annular baffle I606, an annular baffle II 607, a connecting column 608, a through hole 7, a limiting groove 8 and a spring II 9.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only partial embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail with reference to the accompanying drawings 1 to 11, in conjunction with the embodiments.
Example 1
Example 1 describes a method for preparing magnesium palmitate, as shown in fig. 1-3, comprising a seat plate 1, a pulverizer housing 2, a motor 3 and a discharge pipe 4; the preparation equipment further comprises a blade cleaning assembly 5 and a mounting assembly 6; the upper surfaces of the seat plates 1 are fixedly connected with a crusher shell 2, and one side of the crusher shell 2 is fixedly connected with a horizontally arranged motor 3; the lower end of the crusher shell 2 is fixedly connected with a discharge pipe 4, and the discharge pipe 4 penetrates through the seat plate 1;
as shown in fig. 4-7; the upper end of the crusher shell 2 is fixedly connected with a blade cleaning assembly 5; the blade cleaning assembly 5 comprises a handle 501, a pair of guide sleeves 502, a pair of springs 503, a pair of movable rods 504 and a blade cleaning brush 505, wherein the guide sleeves 502 are fixedly connected to the top end of the outer side surface of the crusher shell 2 through connecting plates and bolts, and the pair of guide sleeves 502 are vertical to the crusher shell 2; the guide sleeves 502 are respectively positioned at the left side and the right side of the crusher shell 2, and the crushing blade positioned in the crusher shell 2 is positioned right below the area between the guide sleeves 502; two ends of the handle 501 are respectively and fixedly connected with a connecting sleeve 506, the connecting sleeves 506 are sleeved on the top end of the movable rod 504 and are fixedly connected to the movable rod 504 through bolts, and the movable rod 504 is perpendicular to the handle 501; the bottom ends of the movable rods 504 penetrate through a guide sleeve 502 and then are fixedly connected with a first mounting plate 507, and the first mounting plate 507 and the crusher shell 2 are fixedly connected with the upper surface of a blade cleaning brush 505 positioned in the crusher shell 2 through a mounting assembly 6; a plurality of balls 508 are fixedly connected to the inner wall of the guide sleeve 502; the ball 508 is in close contact with the outer side surface of the movable rod 504, and the movable rod 504 can freely slide in the vertical direction along the guide sleeve 502;
a first spring 503 is sleeved on the pair of movable rods 504; the top end of the first spring 503 is tightly propped against the inner side surface of the crusher shell 2; the bottom end of the first spring 503 is tightly abutted against the upper surface of the blade cleaning brush 505; when the first spring 503 is at its natural length, the blade cleaning brush 505 is away from the crushing blade; when the movable rod 504 is completely immersed into the guide sleeve 502, the spring I503 is in a compressed state, and the brush part of the blade cleaning brush 505 is in contact with the crushing blade
The preparation method of magnesium palmitate fatty acid with the preparation equipment provided in the embodiment 1 comprises the following steps:
step one, mixing 200g of palm oil, 10g of magnesium oxide, 20g of magnesium hydroxide, 1-3g of magnesium lauryl sulfate, 400g of 90% ethanol solution and 2g of hydrogen peroxide, and performing strong pulping and dispersing for 2 hours;
step two, adding 2g of natural activated carbon and 10g of sodium hydroxide, heating to a reflux state, and keeping for 2-4 hours;
step three, controlling the temperature at 40-50 ℃, and carrying out reduced pressure distillation to remove ethanol and water;
step four, maintaining the vacuum degree of-0.005 to-0.01 Mpa, raising the temperature to 100 ℃ and 120 ℃, and maintaining for 1 to 1.5 hours;
and step five, adding 1000g of deionized water, stirring, filtering while the solution is hot, and evaporating the filtrate to dryness.
The working principle is as follows: the handle 501 enables the blade cleaning brush 505 to move away from or close to the crushing blade by actuating the movable lever 504. The motor 3 is turned off, the handle 501 is pressed down until the movable rod 504 is completely immersed into the guide sleeve 502, at the moment, the brush part of the blade cleaning brush 505 is contacted with the crushing blade, the residual rotation potential energy of the crushing blade can keep the blade to continuously and slowly rotate, and at the moment, the blade cleaning brush 505 can completely clean the powder attached to the crushing blade; by arranging the ball 508 in the guide sleeve 502 and providing rolling friction between the movable rod 504 and the ball 508, the friction resistance between the movable rod 504 and the guide sleeve 502 can be effectively reduced, and the friction loss between the movable rod 504 and the guide sleeve 502 can be reduced; the first spring 503 is sleeved on the area, located inside the crusher shell 2, of the movable rod 504, one end of the first spring 503 is tightly abutted to the inner wall of the crusher shell 2, the other end of the first spring is tightly abutted to the upper surface of the blade cleaning brush 505, when pressure is not applied to the handle 501, the brush part of the blade cleaning brush 505 is automatically away from the crushing blade under the action of the first spring 503, and the situation that the blade cleaning brush 505 is crushed by the crushing blade due to the fact that an operator forgets to restore the blade cleaning brush 505 to the original position is avoided.
Example 2
Embodiment 2 is an improvement on embodiment 1, as shown in fig. 8 to 10, wherein the mounting plate I507 is provided with a through hole 7 which has the same shape as the limiting plate 604 and vertically penetrates through the mounting plate I507, the upper surface of the mounting plate I507 is further provided with a limiting groove 8, and the limiting groove 8 is partially intersected with the through hole 7; each mounting plate I507 is provided with a pair of mounting assemblies 6 in a matched manner, each mounting assembly 6 comprises a fixing sleeve 601, a torsion bar 602, a knob 603 and a limiting plate 604, the bottom end of the fixing sleeve 601 is fixedly connected to the upper surface of the blade cleaning brush 505 through a mounting plate II 605, and the fixing sleeve 601 is perpendicular to the blade cleaning brush 505; an annular baffle plate I606 is fixedly connected to the inner side wall of the top end of the fixed sleeve 601; the bottom end of the torsion bar 602 is fixedly connected with a second annular baffle 607, the top end of the torsion bar 602 penetrates through the fixing sleeve 601 from the bottom end of the fixing sleeve 601, and the bottom end of the torsion bar 602 is positioned inside the fixing sleeve 601; the torsion bar 602 can rotate freely around the fixing sleeve 601360 ° and the torsion bar 602 can slide freely along the fixing sleeve 601 in the vertical direction, the torsion bar 602 is prevented from falling out of the fixing sleeve 601 by the engagement of the annular baffle II 607 by the annular baffle I606, and the outer side wall of the annular baffle II 607 is in close contact with the inner side wall of the fixing sleeve 601; the top end of the torsion bar 602 is fixedly connected to the lower surface of the limiting plate 604, the central position of the upper surface of the limiting plate 604 is fixedly connected with a connecting column 608, and the top end of the connecting column 608 is fixedly connected with a knob 603; the lower end of the knob handle 603 is connected to a connecting column 608 through a connecting sleeve 506 and a bolt fixing sleeve 601, and the center lines of the limiting plate 604 and the torsion bar 602 are overlapped.
The preparation method of magnesium palmitate fatty acid with the preparation equipment provided in the embodiment 1 comprises the following steps:
step one, mixing 100g of palm oil, 50g of magnesium oxide, 10g of magnesium hydroxide, 1g of magnesium lauryl sulfate, 200g of 90% ethanol solution and 1g of hydrogen peroxide, and dispersing for 2 hours through strong pulping;
step two, adding 1g of natural active carbon and 50g of sodium hydroxide, heating to a reflux state, and keeping for 2-4 hours;
step three, controlling the temperature at 40-50 ℃, and carrying out reduced pressure distillation to remove ethanol and water;
step four, maintaining the vacuum degree of-0.005 to-0.01 Mpa, raising the temperature to 100 ℃ and 120 ℃, and maintaining for 1 to 1.5 hours;
and step five, adding 500g of deionized water, stirring, filtering while the solution is hot, and evaporating the filtrate to dryness.
In the embodiment, the mounting assembly 6 is arranged between the movable rod 504 and the blade cleaning brush 505, the fixing sleeve 601, the torsion bar 602, the knob 603 and the limiting plate 604 are arranged on the mounting assembly 6, the torsion bar 602 is pulled upwards, the distance between the limiting plate 604 and the upper surface of the mounting plate I507 can be increased, the limiting plate 604 is higher than the upper surface of the mounting plate I507, the knob 603 can be conveniently rotated until the limiting plate 604 is positioned right above the limiting groove 8, the limiting plate 604 is released to be clamped in the limiting groove 8, the movable rod 504 and the blade cleaning brush 505 can be detachably and fixedly connected, and the blade cleaning brush 505 can be conveniently replaced and mounted; .
Example 3
In this embodiment, further, by adding the second spring 9 between the fixing sleeve 601 and the torsion bar 602, after the knob 603 is released, the limiting plate 604 is always tightly engaged in the limiting groove 8 by the resilience of the second spring 9, so that the stable connection between the blade cleaning brush 505 and the movable rod 504 can be ensured.
The preparation method of magnesium palmitate fatty acid with the preparation equipment provided in the embodiment 1 comprises the following steps:
step one, mixing 400g of palm oil, 20g of magnesium oxide, 40g of magnesium hydroxide, 4g of magnesium lauryl sulfate, 800g of 90% ethanol solution and 4g of hydrogen peroxide, and performing strong pulping and dispersing for 2 hours;
step two, adding 4g of natural activated carbon and 20g of sodium hydroxide, heating to a reflux state, and keeping for 2-4 hours;
step three, controlling the temperature at 40-50 ℃, and carrying out reduced pressure distillation to remove ethanol and water;
step four, maintaining the vacuum degree of-0.005 to-0.01 Mpa, raising the temperature to 100 ℃ and 120 ℃, and maintaining for 1 to 1.5 hours;
and step five, adding 2000g of deionized water, stirring, filtering while the solution is hot, and evaporating the filtrate to dryness.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The preparation method of the magnesium palm oil fatty acid is characterized by comprising the following steps of:
step one, adding 90% ethanol solution of palm oil, magnesium oxide, magnesium hydroxide, magnesium lauryl sulfate and hydrogen peroxide dropwise, and dispersing for 2 hours through strong pulping;
step two, adding natural active carbon and sodium hydroxide, heating to a reflux state and keeping for 2-4 hours;
step three, controlling the temperature at 40-50 ℃, and carrying out reduced pressure distillation to remove ethanol and water;
step four, maintaining the vacuum degree of-0.005 to-0.01 Mpa, raising the temperature to 100 ℃ and 120 ℃, and maintaining for 1 to 1.5 hours;
and step five, adding deionized water, stirring, filtering while hot, and evaporating the filtrate to dryness.
2. The method for preparing magnesium palm oil fatty acid according to claim 1, wherein the mass ratio of magnesium oxide, magnesium hydroxide and magnesium lauryl sulfate in the first step is 10:20: 1-3.
3. The method for preparing magnesium palm oil fatty acid according to claim 2, wherein in the first step, the mass ratio of the palm oil, the magnesium oxide, the magnesium hydroxide and the magnesium lauryl sulfate to the 90% ethanol solution is 200: 10:20:1-3:400.
4. The method for preparing magnesium palm oil fatty acid according to claim 3, wherein the amount of hydrogen peroxide added in the first step is 1% of palm oil.
5. The method for preparing magnesium palm oil fatty acid according to claim 4, wherein the natural activated carbon is added in an amount of 1% by mass and the sodium hydroxide is added in an amount of 5% by mass based on the palm oil in the second step.
6. The method according to claim 4, wherein the amount of the deionized water added in step five is 5 times of the amount of the palm oil.
7. Use of magnesium palm oil fatty acid according to any one of claims 1 to 6 in the preparation of a pharmaceutical aid or adjuvant.
8. A manufacturing plant for the preparation of magnesium palm oil fatty acid as claimed in any of claims 1 to 7, comprising a seat plate (1), a mill housing (2), a motor (3) and a discharge pipe (4); characterized in that the preparation apparatus further comprises a blade cleaning assembly (5) and a mounting assembly (6); the upper surfaces of the seat plates (1) are fixedly connected with a crusher shell (2), and one side of the crusher shell (2) is fixedly connected with a horizontally arranged motor (3); the lower end of the crusher shell (2) is fixedly connected with a discharge pipe (4), and the discharge pipe (4) penetrates through the seat plate (1);
the upper end of the crusher shell (2) is fixedly connected with a blade cleaning assembly (5); the blade cleaning assembly (5) comprises a handle (501), a pair of guide sleeves (502), a pair of springs (503), a pair of movable rods (504) and a blade cleaning brush (505), the guide sleeves (502) are fixedly connected to the top end of the outer side face of the crusher shell (2) through a connecting plate and bolts, and the pair of guide sleeves (502) are perpendicular to the crusher shell (2); the guide sleeves (502) are respectively positioned at the left side and the right side of the crusher shell (2), and the crushing blade positioned in the crusher shell (2) is positioned right below the area between the guide sleeves (502); two ends of the handle (501) are respectively and fixedly connected with a connecting sleeve (506), the connecting sleeve (506) is sleeved at the top end of the movable rod (504) and is fixedly connected to the movable rod (504) through a bolt, and the movable rod (504) is perpendicular to the handle (501); the bottom ends of the movable rods (504) penetrate through a guide sleeve (502) and then are fixedly connected with a first mounting plate (507), and the first mounting plate (507) and the rear part of the crusher shell (2) are fixedly connected with the upper surface of a blade cleaning brush (505) positioned in the crusher shell (2) through a mounting assembly (6); the inner wall of the guide sleeve (502) is fixedly connected with a plurality of balls (508); the ball (508) is closely contacted with the outer side surface of the movable rod (504), and the movable rod (504) can freely slide along the guide sleeve (502) in the vertical direction;
a first spring (503) is sleeved on the pair of movable rods (504); the top end of the first spring (503) is tightly propped against the inner side surface of the crusher shell (2); the bottom end of the first spring (503) is tightly propped against the upper surface of the blade cleaning brush (505); when the first spring (503) is in a natural length, the blade cleaning brush (505) is far away from the crushing blade; when the movable rod (504) is completely immersed into the guide sleeve (502), the first spring (503) is in a compressed state, and the brush part of the blade cleaning brush (505) is contacted with the crushing blade;
the mounting plate I (507) is provided with a through hole (7) which is in the same shape as the limiting plate (604) and vertically penetrates through the mounting plate I (507), the upper surface of the mounting plate I (507) is also provided with a limiting groove (8), and the limiting groove (8) is partially intersected with the through hole (7); the mounting assembly (6) comprises a fixing sleeve (601), a torsion bar (602), a knob handle (603) and a limiting plate (604), the bottom end of the fixing sleeve (601) is fixedly connected to the upper surface of the blade cleaning brush (505) through a second mounting plate (605), and the fixing sleeve (601) is perpendicular to the blade cleaning brush (505); the inner side wall of the top end of the fixed sleeve (601) is fixedly connected with a first annular baffle (606); the bottom end of the torsion bar (602) is fixedly connected with a second annular baffle (607), the top end of the torsion bar (602) penetrates through the fixing sleeve (601) from the bottom end of the fixing sleeve (601), and the bottom end of the torsion bar (602) is positioned inside the fixing sleeve (601); the torsion bar (602) can freely rotate around the fixing sleeve (601) by 360 degrees and the torsion bar (602) can freely slide along the fixing sleeve (601) in the vertical direction, the torsion bar (602) is prevented from being disengaged from the fixing sleeve (601) by the first annular baffle (606) through the second annular baffle (607), and the outer side wall of the second annular baffle (607) is tightly contacted with the inner side wall of the fixing sleeve (601); a second spring (9) is sleeved on the torsion bar (602), the second spring (9) is located inside the fixing sleeve (601), one end of the second spring (9) abuts against the upper surface of the second annular baffle (607), and the other end of the second spring (9) abuts against the lower surface of the first annular baffle (606); the second spring (9) is a compression spring, and the central lines of the fixed sleeve (601), the torsion bar (602), the first annular baffle (606), the second annular baffle (607) and the second spring (9) are superposed;
the top end of the torsion bar (602) is fixedly connected to the lower surface of the limiting plate (604), the central position of the upper surface of the limiting plate (604) is fixedly connected with a connecting column (608), and the top end of the connecting column (608) is fixedly connected with a knob handle (603); the lower end of the knob handle (603) is connected to a connecting column (608) through a connecting sleeve (506) and a bolt fixing sleeve (601), and the center lines of the limiting plate (604) and the torsion bar (602) are superposed.
9. The magnesium palmitate manufacturing apparatus according to claim 8, wherein a pair of mounting assemblies (6) is provided for each mounting plate I (507).
10. The magnesium palm oil fatty acid salt production facility according to claim 9, wherein; after the knob handle (603) and the limiting plate (604) penetrate through the through hole, the knob handle (603) is released when the knob handle (603) is rotated until the limiting plate (604) is positioned right above the limiting groove (8), and the limiting plate (604) is tightly clamped in the limiting groove (8) under the stretching action of the second spring (9).
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| CN107335513A (en) * | 2016-05-03 | 2017-11-10 | 天津市川浩塑料制品有限公司 | A kind of Material disintegrator |
| CN109350672A (en) * | 2017-10-09 | 2019-02-19 | 刘常春 | A kind of nanometer of tea oil fatty acid calcium iron zinc complexes and its preparation method and application |
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| CN109503357A (en) * | 2018-12-25 | 2019-03-22 | 维思普新材料（苏州）有限公司 | A kind of continuous preparation method of metal fatty acid salt |
| CN111646891B (en) * | 2020-07-01 | 2021-01-19 | 中山华明泰科技股份有限公司 | Preparation method and application of medicinal composite plant fatty acid calcium |
| CN111606799B (en) * | 2020-07-02 | 2021-01-05 | 中山华明泰科技股份有限公司 | Preparation method and application of medicinal composite vegetable fatty acid magnesium |
| CN111909026B (en) * | 2020-08-10 | 2021-03-12 | 中山华明泰科技股份有限公司 | Preparation method and application of palm oil fatty acid calcium |
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