CN112773961A - Oxygenator, oxygenator hollow fiber membrane woven assembly and forming method thereof - Google Patents
Oxygenator, oxygenator hollow fiber membrane woven assembly and forming method thereof Download PDFInfo
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- CN112773961A CN112773961A CN202011608907.8A CN202011608907A CN112773961A CN 112773961 A CN112773961 A CN 112773961A CN 202011608907 A CN202011608907 A CN 202011608907A CN 112773961 A CN112773961 A CN 112773961A
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- hollow fiber
- oxygenator
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- weaving
- fiber membrane
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- 239000012510 hollow fiber Substances 0.000 title claims abstract description 224
- 239000012528 membrane Substances 0.000 title claims abstract description 57
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000009941 weaving Methods 0.000 claims abstract description 71
- 230000017531 blood circulation Effects 0.000 claims abstract description 68
- 238000007789 sealing Methods 0.000 claims abstract description 34
- 239000003292 glue Substances 0.000 claims abstract description 29
- 239000000835 fiber Substances 0.000 claims description 75
- 239000011148 porous material Substances 0.000 claims description 23
- 238000009954 braiding Methods 0.000 claims description 13
- 230000001154 acute effect Effects 0.000 claims description 3
- 229910003460 diamond Inorganic materials 0.000 claims description 3
- 239000010432 diamond Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000004026 adhesive bonding Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 37
- 210000004369 blood Anatomy 0.000 description 37
- 238000006213 oxygenation reaction Methods 0.000 description 14
- 230000008859 change Effects 0.000 description 12
- 230000008569 process Effects 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- 230000003247 decreasing effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000009940 knitting Methods 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004382 potting Methods 0.000 description 3
- 239000000565 sealant Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
- WSSSPWUEQFSQQG-UHFFFAOYSA-N 4-methyl-1-pentene Chemical compound CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 1
- 206010073734 Microembolism Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/021—Manufacturing thereof
- B01D63/022—Encapsulating hollow fibres
Abstract
The invention discloses an oxygenator hollow fiber membrane weaving assembly which comprises a hollow fiber membrane part and a glue sealing part, wherein the hollow fiber membrane part comprises a plurality of hollow fiber units which are sequentially stacked; the sealing part is sealed on the outer edges of the stacked hollow fiber units; the section of the inner ring of the glue sealing part is oval, so that a plurality of hollow fiber units which are stacked are matched to form a blood flow channel with an oval cross section; the invention also discloses a method for forming the hollow fiber membrane woven assembly of the oxygenator and the oxygenator. This application is through the cooperation of the hollow fiber unit of gluing portion and a plurality of range upon range of settings, and the cross section of formation is oval-shaped blood flow passageway no dead angle position, and blood flows smoothly.
Description
Technical Field
The invention relates to the technical field of oxygenators, in particular to an oxygenator, a hollow fiber membrane weaving assembly of the oxygenator and a forming method of the hollow fiber membrane weaving assembly.
Background
Hollow fibers are widely used in oxygenators and participate in the oxygenation and temperature changing functions of the oxygenators. When the hollow fiber is used for oxygenation, the blood realizes the exchange of oxygen and carbon dioxide in the diffusion process of the hollow fiber membrane, so that the blood absorbs the oxygen and discharges the carbon dioxide; when the hollow fiber is used for the temperature changing function, the hollow fiber is pre-filled with temperature changing water, and the blood realizes heat transfer in the diffusion process of the hollow fiber membrane, so that the temperature of the blood is increased or decreased. Existing oxygenators are distinguished in shape by a cylindrical oxygenator and a cube-shaped oxygenator. The blood diffuses from the inner core to the cylindrical shell, the hollow fiber membrane for oxygenation and temperature change is sleeved between the inner core and the shell layer by layer, the surface area of the hollow fiber membrane is changed from small to large from inside to outside, if the oxygenation and temperature change functions of the blood in the diffusion process of the hollow fiber membrane are to be realized, transmembrane pressure difference and integral precharge quantity are met, clinical application is met, and the design requirements on blood flow guiding and uniform diffusion structures and the like of the oxygenator are high. In the cubic oxygenator, the hollow fiber membranes are arranged in a laminated manner, the surface area of each layer of hollow fiber membrane is the same, blood can cross the hollow fiber membranes to realize oxygenation and temperature change functions, the transmembrane pressure difference of the oxygenator with the structure is relatively small, the design requirement is relatively low, but the blood flow at the four corner positions and the positions adjacent to the corner positions of the cubic oxygenator is not smooth, and the dead corner positions are easily formed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an oxygenator, an oxygenator hollow fiber membrane woven assembly and a forming method thereof.
The invention discloses an oxygenator hollow fiber membrane weaving assembly, which comprises: a hollow fiber membrane section including a plurality of hollow fiber units; the plurality of hollow fiber units are sequentially stacked;
a sealing part which seals the outer edges of the plurality of hollow fiber units which are arranged in a laminated manner; the cross section of the inner ring of the glue sealing part is oval, so that a plurality of hollow fiber units which are stacked are matched to form a blood flow channel with an oval cross section.
According to an embodiment of the present invention, the cross section of the inner ring of the sealing compound portion is circular, so that the stacked hollow fiber units cooperate to form a blood flow channel with a circular cross section.
According to an embodiment of the present invention, the hollow fiber unit has a plurality of flow-through pores; the areas of the overflowing holes formed by the hollow fiber units sequentially stacked from one end of the blood flow channel to the other end of the blood flow channel are different.
According to an embodiment of the present invention, the hollow fiber unit has a plurality of flow-through pores; the density of the flow holes in the unit area of the hollow fiber unit is different from one end of the blood flow channel to the other end of the blood flow channel.
According to an embodiment of the present invention, the hollow fiber unit has a plurality of flow-through pores; from one end of the blood flow channel to the other end of the blood flow channel, the area and/or the density of the flow pores in the unit area of the hollow fiber unit gradually becomes smaller.
According to an embodiment of the present invention, the hollow fiber unit has a plurality of flow-through pores; from one end of the blood flow channel to the other end of the blood flow channel, the area and/or the density of the flow pores in the unit area of the hollow fiber unit gradually become larger.
According to an embodiment of the present invention, a hollow fiber unit includes a first hollow fiber layer and a second hollow fiber layer which are stacked; the first hollow fiber layer comprises a plurality of first fiber pipes which are sequentially arranged at intervals, and the second hollow fiber layer comprises a plurality of second fiber pipes which are sequentially arranged at intervals; the first fiber tubes and the second fiber tubes are arranged in a staggered mode respectively, and a plurality of flow passing holes are formed.
According to one embodiment of the present invention, the first fiber tube is perpendicular to the second fiber tube, and the flow passage aperture is rectangular.
According to one embodiment of the present invention, the included angle between the first fiber tube and the second fiber tube is an acute angle, and the flow passage aperture is a diamond shape.
A method for forming a hollow fiber membrane braided component of an oxygenator comprises the following steps:
sequentially weaving a plurality of hollow fiber units, and sequentially stacking the hollow fiber units;
performing centrifugal glue pouring on the outer edges of the plurality of hollow fiber units which are stacked to form a glue sealing part; the section of the inner ring of the glue sealing part is oval, and a plurality of hollow fiber units which are stacked are matched to form a blood flow channel with an oval cross section; preferably, the section of the inner ring of the glue sealing part is circular, and the section of the inner ring of the glue sealing part is circular;
and cutting the outer edge of the glue sealing part to leak the hollow fiber units.
According to an embodiment of the present invention, weaving a plurality of hollow fiber units includes:
weaving the first hollow fiber layer;
weaving a second hollow fiber layer above the first hollow fiber layer;
the first hollow fiber layer and the second hollow fiber layer are matched to form a hollow fiber unit with a plurality of flow passing pores.
According to an embodiment of the present invention, weaving a first hollow fiber layer includes:
a first fiber tube is S-routed in a first direction.
According to an embodiment of the present invention, a method of weaving a second hollow fiber layer over a first hollow fiber layer includes:
and S-shaped routing a second fiber tube along a second direction above the first fiber tube.
An oxygenator comprises the oxygenator hollow fiber membrane woven assembly.
The beneficial effect of this application lies in: through the matching of the glue sealing part and the plurality of hollow fiber units which are arranged in a stacked mode, a blood flow channel with an oval cross section is formed, dead corners do not exist, and blood flows smoothly; when blood crosses a plurality of hollow fiber units which are arranged in a stacked mode, a blood flow path can be indirectly shortened, and pressure loss can be reduced; the variable area and/or the density of the flow passing pores in the unit area of the hollow fiber unit can better realize the flow guide of blood and meet the application requirements of different products; meanwhile, the contact area between the hollow fiber unit and blood can be effectively increased, the utilization rate of the surface area of the hollow fiber unit is increased, and the oxygenation and temperature change effects are improved.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:
FIG. 1 is a schematic structural view of a hollow fiber membrane braid assembly of an embodiment oxygenator;
FIG. 2 is a schematic structural view of another perspective of an example oxygenator hollow fiber membrane braid assembly;
FIG. 3 is a sectional view taken along the line A-A of FIG. 2 in the example;
FIG. 4 is a schematic structural view of a hollow fiber membrane portion in an embodiment;
FIG. 5 is an enlarged view of the portion B of FIG. 2 in the example;
FIG. 6 is an enlarged view of the portion C of FIG. 4 in the example;
FIG. 7 is a flow chart of a method for forming a woven assembly of hollow fiber membranes of an oxygenator in an embodiment;
FIG. 8 is a schematic view showing a woven structure of a hollow fiber unit in the embodiment;
FIG. 9 is a schematic view of another perspective of the woven structure of the hollow fiber unit of the embodiment;
FIG. 10 is an enlarged view of the D portion of FIG. 8 in the example;
fig. 11 is a schematic structural view of a first braided column in another embodiment.
Detailed Description
In the following description, for purposes of explanation, numerous implementation details are set forth in order to provide a thorough understanding of the various embodiments of the present invention. It should be understood, however, that these implementation details are not to be interpreted as limiting the invention. That is, in some embodiments of the invention, such implementation details are not necessary. In addition, some conventional structures and components are shown in simplified schematic form in the drawings.
It should be noted that all the directional indications such as up, down, left, right, front and rear … … in the embodiment of the present invention are only used to explain the relative positional relationship, movement, etc. between the components in a specific posture as shown in the drawings, and if the specific posture is changed, the directional indication is changed accordingly.
In addition, the descriptions related to the first, the second, etc. in the present invention are only used for description purposes, do not particularly refer to an order or sequence, and do not limit the present invention, but only distinguish components or operations described in the same technical terms, and are not understood to indicate or imply relative importance or implicitly indicate the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
In order to further understand the contents, features and effects of the present invention, the following embodiments are illustrated and described in detail with reference to the accompanying drawings:
example one
Referring to fig. 1 to 4, fig. 1 is a schematic structural view of an oxygenator hollow fiber membrane braid assembly according to an embodiment, fig. 2 is a schematic structural view of another view of the oxygenator hollow fiber membrane braid assembly according to the embodiment, fig. 3 is a sectional view taken along the plane a-a of fig. 2 according to the embodiment, and fig. 4 is a schematic structural view of a hollow fiber membrane portion according to the embodiment. The oxygenator hollow fiber membrane woven assembly in the present embodiment includes a hollow fiber membrane portion 1 and a sealant portion 2. The hollow fiber membrane part 1 comprises a plurality of hollow fiber units 11, and the plurality of hollow fiber units 11 are sequentially stacked; the sealant part 2 is sealed on the outer edges of the plurality of hollow fiber units 11 which are stacked; the section of the inner ring of the glue sealing part 2 is oval, so that a plurality of hollow fiber units 11 which are stacked are matched to form a blood flow channel with an oval cross section; the section of the inner circle of the sealing part 2 is preferably circular, so that a plurality of hollow fiber units 11 which are stacked together cooperate to form a blood flow channel with a circular cross section.
Through the matching of the glue sealing part 2 and the plurality of hollow fiber units 11 which are arranged in a stacked mode, a blood flow channel with an oval or circular cross section is formed, dead corner positions do not exist, and blood flows smoothly; when blood crosses a plurality of hollow fiber units 11 which are stacked, a blood flow path can be indirectly shortened, and pressure loss can be reduced; in addition, the effective contact area of the hollow fiber unit 11 and blood is increased, so that the utilization rate of the surface area of the hollow fiber unit 11 is increased, and the oxygenation and temperature change effects are improved. The outer edge of the hollow fiber unit 11 in this embodiment is the peripheral edge of the hollow fiber unit 11.
Referring to fig. 5 and 6 together, fig. 5 is an enlarged view of a portion B of fig. 2 in the embodiment, and fig. 6 is an enlarged view of a portion C of fig. 4 in the embodiment. Further, the hollow fiber unit 11 has a plurality of flow-through pores 111. The areas of the flow passage holes 111 formed by the hollow fiber units 11 stacked in sequence from one end of the blood flow channel to the other end of the blood flow channel are different from each other. Further, the density of the flow holes 111 per unit area of the hollow fiber unit 11 varies from one end of the blood flow channel to the other end of the blood flow channel.
Specifically, the hollow fiber unit 11 includes a first hollow fiber layer 112 and a second hollow fiber layer 113 that are stacked. The first hollow fiber layer 112 includes a plurality of first fiber tubes 1121 arranged in sequence at intervals, and the second hollow fiber layer 113 includes a plurality of second fiber tubes 1131 arranged in sequence at intervals. The first fiber tubes 1121 are disposed in a staggered manner from the second fiber tubes 1131, and form a plurality of flow apertures 111. In this embodiment, the first fiber tube 1121 and the second fiber tube 1131 are both hollow fiber tubes.
Further, from the end where the blood flows in to the other end where the blood flows out, the area and/or density of the flow holes 111 per unit area of the hollow fiber unit 11 gradually becomes smaller.
Further, the area and/or density of the flow-through pores 111 per unit area of the hollow fiber unit 11 gradually becomes larger from the end where blood flows in to the other end where blood flows out.
It can be understood that, when blood is oxygenated or temperature-changed, the larger the area of the flow-through pores 111 formed by the hollow fiber units 11 arranged in sequence in a stacked manner is, the smaller the resistance force of the blood crossing the hollow fiber units 11 is, the greater the density of the flow-through pores 111 per unit area is, the smaller the crossing ability of the blood and the possible macroembolus molecules is, and vice versa.
Taking the example that the area of the through-flow pores 111 formed by the hollow fiber units 11 sequentially stacked increases gradually from the end where the blood flows in to the other end where the blood flows out, the resistance to the blood flowing in the oxygenator hollow fiber membrane knitted component (i.e. the resistance to the blood crossing the hollow fiber units 11) is a gradual process from large to small, because the blood enters the oxygenator hollow fiber membrane knitted component with a large contact area through a pipe (not shown) with a small pipe diameter connected externally, this is a process of decreasing resistance, and the blood finally flows out from the oxygenator hollow fiber membrane knitted component with a large contact area through a pipe (not shown) with a small pipe diameter connected externally, this is a process of increasing resistance, and the area of the through-flow pores 111 formed by the hollow fiber units 11 sequentially stacked increases gradually, the resistance change trend in the whole flowing process is more gradual, so that the damage of blood caused by the resistance change of the blood flowing in the blood flow can be reduced.
Taking the case that the density of the flow-passing pores 111 per unit area gradually increases from the end where blood flows in to the other end where blood flows out, because the micro-embolism molecules possibly generated by the blood flowing in the hollow fiber membrane woven component of the oxygenator and the blood viscosity of individual patients are different, if the density of the flow-through pores 111 per unit area at the blood inflow end is small, when a large number of micro-embolus molecules are generated or the viscosity of blood is large, can smoothly cross the oxygenator hollow fiber membrane weaving assembly firstly, and then the oxygenator hollow fiber membrane weaving assembly is reduced and thinned by repeated flushing in the flowing process, and finally the oxygenator hollow fiber membrane weaving assembly smoothly flows out from the outflow end, otherwise, the flow passage apertures 111 may be blocked at the initial inflow end, and when the flow passage apertures 111 are blocked to a certain extent, the utilization efficiency and effect thereof are greatly reduced, and the service life thereof is severely shortened.
Further, defining one end of the blood flow channel as a liquid inlet end and the other end of the blood flow channel as a liquid outlet end, the first fiber tube 1121 and/or the second fiber tube 1131 near the liquid inlet end of the blood flow channel have a circular closed cross section, and the first fiber tube 1121 and/or the second fiber tube 1131 near the liquid outlet end of the blood flow channel have a non-circular closed cross section. Furthermore, the first fiber tubes 1121 and/or the second fiber tubes 1131 near the inlet end of the blood flow channel are made of hollow fiber membranes capable of achieving a temperature change effect, such as polyester PET membranes, while the first fiber tubes 1121 and/or the second fiber tubes 1131 near the outlet end of the blood flow channel are made of hollow fiber membranes capable of achieving an oxygen and carbon dioxide exchange effect, such as polypropylene PP membranes, poly-4-methyl-1-pentene PMP membranes, and the like. According to the equal-period principle: when the area enclosed by the closed curve on the plane is fixed, the circumference of the circular curve is minimum, so that the non-circular closed-section fiber tube can realize larger contact area between gas molecules and blood under the same flow rate, thereby realizing the exchange between more gas molecules and blood and further improving the oxygenation efficiency of blood and oxygen; hollow fiber membranes made with poly-4-methyl-1-pentene (PMP) have better oxygen flux and support longer blood circulation cycles.
Preferably, the first fiber tubes 1121 are perpendicular to the second fiber tubes 1131, and the flow apertures 111 are rectangular. The included angle between the first fiber tube 1121 and the second fiber tube 1131 is an acute angle, and the flow passage aperture 111 is in a diamond shape. In a specific application, the arrangement interval and the arrangement angle of the first fiber tubes 1121 and/or the second fiber tubes 1131 can be set according to actual requirements, so that the shape and size of the flow passage apertures 111 can be flexibly adjusted to adapt to form different oxygenator products.
Referring to fig. 1 to 3 again, further, the molding of the sealant 2 may be achieved by centrifugal potting, specifically, a hollow fiber layer 112 and a second hollow fiber layer 113 in the second hollow fiber unit 11 are sequentially woven and fixed, so that a plurality of hollow fiber units 11 are stacked. Then, the outer edges of the plurality of hollow fiber units 11 stacked one on another are filled with glue by a centrifugal glue filling method. After the glue is solidified, a sealing end 2 is formed, and at the moment, a blood flow channel with an oval or circular cross section is formed on the inner ring of the sealing part 2. Finally, the through holes of the first fiber tube 1121 and the second fiber tube 1131 are exposed at the portion of the edge of the sealing end 2.
The process of oxygenation or temperature change of blood in this example is as follows: blood flowing from the inlet end of the blood flow channel to the outlet end of the blood flow channel passes through the flow apertures 111 and flows over the surfaces of the first fiber tubes 1121 and the second fiber tubes 1131. Meanwhile, when pure oxygen or pure oxygen plus air is injected into the through holes of the first fiber tube 1121 and the second fiber tube 1131 after leaking from the sealing end 2, oxygen inside the first fiber tube 1121 and the second fiber tube 1131 exchanges oxygen and carbon dioxide with blood at the outer walls of the first fiber tube 1121 and the second fiber tube 1131, thereby completing the oxygenation function. Similarly, when the temperature-changing water leaks from the sealing end 2 to the through holes of the first fiber tube 1121 and the second fiber tube 1131 and is flushed into the through holes, the temperature-changing water inside the first fiber tube 1121 and the second fiber tube 1131 exchanges heat with the blood at the outer walls of the first fiber tube 1121 and the second fiber tube 1131, thereby completing the temperature-changing function. Because the cross section of the blood flow channel is oval or round, a dead angle position does not exist during blood circulation, the blood circulation at any position of the blood flow channel is very smooth, and the variable area and/or density of the flow holes 111 in the unit area of the hollow fiber unit 11 can better realize the flow guide of the blood and meet different product application requirements; meanwhile, the contact area of the hollow fiber unit 11 and blood can be effectively increased, the utilization rate of the surface area of the hollow fiber unit 11 is increased, and the oxygenation and temperature change effects are improved.
Example two
Referring to fig. 7, fig. 7 is a flow chart of a method for forming a woven assembly of hollow fiber membranes in an oxygenator in an embodiment. The method for forming the hollow fiber membrane woven assembly of the oxygenator comprises the following steps of:
s1, a plurality of hollow fiber units 11 are sequentially woven, and the plurality of hollow fiber units 11 are sequentially stacked.
S2, performing centrifugal potting to the outer edges of the stacked hollow fiber units 11 to form a potting portion 2; the section of the inner ring of the glue sealing part 2 is oval or circular, and a plurality of hollow fiber units 11 which are stacked are matched to form a blood flow channel with an oval or circular cross section.
S3, the outer edge of the sealing compound portion 2 is cut to leak the hollow fiber unit 11.
Through weaving a plurality of hollow fiber unit 11 in proper order for a plurality of hollow fiber unit 11 are the structure that stacks gradually, carry out centrifugal encapsulating to the outer fringe of a plurality of hollow fiber unit 11 that set up of stack again, form and seal the gluey portion 2, like this again when fixing a plurality of hollow fiber unit 11, still make the cross-section of sealing the gluey portion 2 for oval or circular inner circle carries out the shape to the blood flow passageway of a plurality of hollow fiber unit 11 that stack up and prescribe a limit to, finally form the cross-section for oval or circular blood flow passageway. Therefore, the blood flow channel without the dead angle position can be formed through simple procedures such as weaving, centrifugal glue filling and the like, the forming is simple, and the formed oxygenator has good oxygenation and temperature changing functions.
Referring to fig. 8 to 10 together, fig. 8 is a schematic view of a weaving structure of a hollow fiber unit in the embodiment, fig. 9 is a schematic view of another perspective view of the weaving structure of the hollow fiber unit in the embodiment, and fig. 10 is an enlarged view of a portion D of fig. 8 in the embodiment. Further, in step S1, weaving the plurality of hollow fiber units 11 includes the substeps of:
s11, the first hollow fiber layer 112 is woven.
S12, the second hollow fiber layer 113 is woven above the first hollow fiber layer 112.
S13, the first hollow fiber layer 112 and the second hollow fiber layer 113 cooperate to form the hollow fiber unit 11 having the plurality of flow passing pores 111.
In step S11, the first hollow fiber layer 112 is woven, including the following sub-steps: s111, a first fiber tube 1121 is subjected to S-shaped tube running along a first direction. Specifically, a first fiber tube 1121 is routed in an S-shape along a first direction by the knitting jig 100. The knitting jig 100 includes a mounting plate 101, a plurality of first knitting posts 102, and a plurality of second knitting posts 103. The plurality of first woven posts 102 and the plurality of second woven posts 103 are perpendicular to the mounting plate 101. The first weaving posts 102 are sequentially mounted on one side of the mounting plate 101 at intervals along the first direction to form a row of first weaving posts 102, and the first weaving posts 102 are sequentially mounted on the other side of the mounting plate 101 at intervals along the first direction to form another row of first weaving posts 102. The sequential connecting lines of the first weaving posts 102 in each row of the first weaving posts 102 are all straight lines, and the sequential connecting lines of the first weaving posts 102 in one row of the first weaving posts 102 are parallel to the sequential connecting lines of the first weaving posts 102 in the other row of the first weaving posts 102. The plurality of second braiding posts 103 are sequentially mounted to one side of the mounting plate 101 at intervals along the second direction to form a row of second braiding posts 103, and the plurality of second braiding posts 103 are sequentially mounted to the other side of the mounting plate 101 opposite to the second direction to form another row of second braiding posts 103. The sequential connecting lines of the second weaving columns 103 in each row of the second weaving columns 103 are all straight lines, and the sequential connecting lines of the second weaving columns 103 in one row of the second weaving columns 103 are parallel to the sequential connecting lines of the second weaving columns 103 in the other row of the second weaving columns 103. The first direction and the second direction are both linear directions. The first direction and the second direction are arranged in a staggered manner, and the second direction in the embodiment is perpendicular to the first direction. Preferably, the interval between two adjacent first weaving columns 102 in the plurality of first weaving columns 102 of each row of first weaving columns 102 is the same, and the plurality of first weaving columns 102 in one row of first weaving columns 102 are directly opposite to the plurality of first weaving columns 102 in the other row of first weaving columns 102. In the plurality of second weaving columns 103 of each row of second weaving columns 103, the interval between two adjacent second weaving columns 103 is the same, and the plurality of second weaving columns 103 in one row of second weaving columns 103 are directly opposite to the plurality of second weaving columns 103 in the other row of second weaving columns 103. Preferably, the sequential connection line of the plurality of first knitting posts 102 and the plurality of second knitting posts 103 is rectangular. In this embodiment, the sequential connection line between the first weaving posts 102 and the second weaving posts 103 is a square. In step S111, a first fiber tube 1121 is S-shaped running along a first direction. The specific process is as follows: a first fiber tube 1121 is sequentially wound around two first weaving columns 102 opposite to each other in the two rows of first weaving columns 102 and S-shaped wound along the first direction, and when the first fiber tube 1121 reaches the last first weaving column 102 of the S-shaped tube, the weaving of the first hollow fiber layer 112 is completed. In another embodiment, the interval between two adjacent first braiding pillars 102 is different, and/or the interval between two adjacent second braiding pillars 103 is different, and the interval between two adjacent first braiding pillars 102 and the interval between two adjacent second braiding pillars 103 may be set according to practical situations in a specific application, and is not limited herein.
When the intervals between two adjacent first woven pillars 102 are different, in step S11, specifically, the first fiber tubes 1121 are sequentially wound around two first woven pillars 102 with the shortest straight distance among the two rows of first woven pillars 102, and S-shaped winding is performed along the first direction, and when the first fiber tubes 1121 reach the last first woven pillar 102 of the S-shaped tube, the weaving of the first hollow fiber layer 112 is completed.
In step S12, the second hollow fiber layer 113 is woven above the first hollow fiber layer 112, including the sub-steps of: s121, a second fiber pipe 1131 is routed in an S-shape along a second direction above the first fiber pipe 1121. Specifically, a second fiber tube 1131 is routed in an S-shape along a second direction by the knitting jig 100. The specific process is as follows: and (3) sequentially winding a second fiber pipe 1131 around two opposite second weaving columns 103 in the two rows of second weaving columns 103 above the first fiber pipe 1121, and performing S-shaped winding along the second direction, wherein when the S-shaped running of the second fiber pipe 1131 reaches the last second weaving column 103, the weaving of the second hollow fiber layer 113 is completed. When the intervals between two adjacent first weaving columns 102 are different, in step S12, specifically, the second fiber tubes 1131 are sequentially wound around two second weaving columns 103 with the shortest straight distance among the two rows of second weaving columns 103, and are wound in an S shape along the second direction, and when the second weaving column 103 reaches the last second weaving column 103 of the S-shaped tube, the weaving of the second hollow fiber layer 113 is completed.
In step S13, the first hollow fiber tubes 1121 of the first hollow fiber layer 112 and the second hollow fiber tubes 1131 of the second hollow fiber layer 113 are crossed in space, and because there is a space between two adjacent first hollow fiber tubes 1121 and a space between two adjacent second hollow fiber tubes 1131, as viewed from a direction perpendicular to the mounting plate 101, a plurality of flow passing apertures 111 are formed, and the first hollow fiber layer 112 and the second hollow fiber layer 113 cooperate to form the hollow fiber unit 11. The through-flow aperture 111 in this embodiment is rectangular.
Changing the interval between two adjacent first braided columns 102, changing the interval between two adjacent second braided columns 103, and changing the included angle between the first direction and the second direction can change the shape of the flow passage hole 111, and in specific applications, the shape can be adjusted according to actual conditions, and details are not repeated here.
After the plurality of hollow fiber units 11 are sequentially stacked, step S2 is executed. In step S2, the outer edges of the stacked hollow fiber units 11 are centrifugally filled with glue to form the glue sealing portion 2, which can be implemented by using an existing centrifugal glue filling machine, during centrifugation, the glue is concentrated toward the outer edges of the stacked hollow fiber units 11, so that the cross section of the inner ring of the glue sealing portion 2 is elliptical, and finally the stacked hollow fiber units 11 are matched to form a blood flow channel with an elliptical cross section.
In step S2, step S3 is executed to cut the outer edge of the glue sealing portion 2 by using an existing cutting mechanism, which is not described herein again. The leaking hollow fiber unit 11 is limited to leaking the through holes of the first fiber tube 1121 and the second fiber tube 1131 without destroying the sealing function of the sealing part 2.
Referring to fig. 11, fig. 11 is a schematic structural view of a first braiding post according to another embodiment. It is understood that, in order to realize that the density of the flow passage apertures 111 per unit area of the hollow fiber units 11 gradually decreases from one end of the blood flow passage to the other end of the blood flow passage, when the first hollow fiber tubes 1121 and the second hollow fiber tubes 1131 are woven, the interval between two adjacent first hollow fiber tubes 1121 or/and second hollow fiber tubes 1131 must be gradually increased or gradually decreased in the direction perpendicular to the mounting plate 101, which makes it necessary for the first woven column 102 to have a structure that enables the interval between the first hollow fiber tubes 1121 of the plurality of hollow fiber units 11 to be gradually increased or decreased or/and for the second woven column 103 to have a structure that enables the interval between the second hollow fiber tubes 1131 of the plurality of hollow fiber units 11 to be gradually increased or decreased in the direction perpendicular to the mounting plate 101. The structure of the first braided wire column 102 will now be described. The first braided strut 102 includes a main strut 1021 and a partial strut 1022. The sub-braided post 1022 includes a cross bar 10221 and two vertical bars 10222. One end of each of the two vertical rods 10222 is vertically connected to the two opposite ends of the cross rod 10221, the cross rod 10221 is parallel to the mounting plate 101, the vertical rod 10222 is vertical to the mounting plate 101, the central point of the cross rod 1022 is connected to one end of the main weaving column 1021, and the other end of the main weaving column 1021 is vertically mounted on the mounting plate 101. As such, along the first direction, a spacing length between two adjacent main rod knitting posts 1021 is set to be L1, a spacing length between two adjacent vertical rods 10222 is set to be L2, and L1 is greater than L2. When the first hollow fiber tubes 1121 are woven, the interval between two adjacent first hollow fiber tubes 1121, which are wound around the main woven column 1021, is L1, and the interval between two adjacent first hollow fiber tubes 1121, which are wound around the vertical bar 10222, is L2, so that the first woven column 102 is configured such that the intervals between the first hollow fiber tubes 1121 of the plurality of hollow fiber units 11 are gradually increased or decreased in a direction perpendicular to the mounting plate 101. If the structure of the first braided column 102 is changed into one-stage bifurcation, the structure of the first braided column 102 or/and the second braided column 103 can be branched in multiple stages according to actual requirements in specific applications, and finally, after the formation by re-braiding, the area of the through-flow pores 111 formed by the hollow fiber units 11 sequentially stacked from one end of the blood flow channel to the other end of the blood flow channel can be gradually increased or decreased, and the density of the through-flow pores 111 in the unit area of the hollow fiber units 11 can be gradually increased or decreased.
In conclusion, through the matching of the glue sealing part and the plurality of hollow fiber units which are arranged in a stacked mode, a blood flow channel with an oval or circular cross section is formed, dead corners do not exist, and blood flows smoothly; when blood crosses a plurality of hollow fiber units which are arranged in a stacked mode, a blood flow path can be indirectly shortened, and pressure loss can be reduced; the variable area and/or the density of the flow passing pores in the unit area of the hollow fiber unit can better realize the flow guide of blood and meet the application requirements of different products; meanwhile, the contact area between the hollow fiber unit and blood can be effectively increased, the utilization rate of the surface area of the hollow fiber unit is increased, and the oxygenation and temperature change effects are improved. The oxygenator of the blood flow channel without the dead angle position can be formed through simple procedures of weaving, centrifugal glue filling and the like, the forming process is simple, and the formed oxygenator has good oxygenation and temperature changing functions.
The above is merely an embodiment of the present invention, and is not intended to limit the present invention. Various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.
Claims (10)
1. An oxygenator hollow fiber membrane braid assembly comprising:
a hollow fiber membrane section (1) including a plurality of hollow fiber units (11); a plurality of the hollow fiber units (11) are sequentially stacked;
a sealing part (2) which seals the outer edges of the plurality of stacked hollow fiber units (11); the section of the inner ring of the glue sealing part (2) is oval, so that a plurality of hollow fiber units (11) which are stacked are matched to form a blood flow channel with an oval cross section.
2. The oxygenator hollow fiber membrane braid assembly of claim 1, wherein the hollow fiber unit (11) has a plurality of flow apertures (111); the areas of the overflowing pores (111) formed by the hollow fiber units (11) sequentially stacked from one end of the blood flow channel to the other end of the blood flow channel are different.
3. The oxygenator hollow fiber membrane braid assembly of claim 2, wherein the hollow fiber unit (11) comprises a first hollow fiber layer (112) and a second hollow fiber layer (113) arranged in a stack; the first hollow fiber layer (112) comprises a plurality of first fiber tubes (1121) which are sequentially arranged at intervals, and the second hollow fiber layer (113) comprises a plurality of second fiber tubes (1131) which are sequentially arranged at intervals; the first fiber tubes (1121) and the second fiber tubes (1131) are arranged in a staggered mode, and a plurality of flow passing pores (111) are formed.
4. The oxygenator hollow fiber membrane braid assembly of claim 3, wherein the first fiber tubes (1121) are perpendicular to the second fiber tubes (1131), the flow apertures (111) being rectangular.
5. The oxygenator hollow fiber membrane braid assembly of claim 3, wherein the first fiber tubes (1121) are angled at an acute angle to the second fiber tubes (1131), and the flow apertures (111) are diamond shaped.
6. A method for forming a hollow fiber membrane woven assembly of an oxygenator is characterized by comprising the following steps:
sequentially weaving a plurality of hollow fiber units (11) and sequentially stacking the hollow fiber units (11);
performing centrifugal glue pouring on the outer edges of the plurality of stacked hollow fiber units (11) to form a glue sealing part (2); the section of the inner ring of the glue sealing part (2) is oval, and a plurality of hollow fiber units (11) which are stacked are matched to form a blood flow channel with an oval cross section;
and cutting the outer edge of the sealing part (2) to leak out the hollow fiber unit (11).
7. The oxygenator hollow fiber membrane braid assembly forming method of claim 6, wherein braiding a plurality of hollow fiber units (11) includes:
weaving a first hollow fiber layer (112);
weaving a second hollow fiber layer (113) over the first hollow fiber layer (112);
the first hollow fiber layer (112) and the second hollow fiber layer (113) cooperate to form a hollow fiber unit (11) having a plurality of flow-through pores (111).
8. The oxygenator hollow fiber membrane braid assembly forming method of claim 7, wherein braiding a first hollow fiber layer (112) comprises:
a first fiber tube (1121) is S-shaped running along a first direction.
9. The oxygenator hollow fiber membrane braid assembly forming method of claim 8, wherein braiding a second hollow fiber layer (113) over the first hollow fiber layer (112) comprises:
and performing S-shaped pipe distribution on a second fiber pipe (1131) along a second direction above the first fiber pipe (1121).
10. An oxygenator comprising the oxygenator hollow fiber membrane braid assembly of any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011608907.8A CN112773961A (en) | 2020-12-30 | 2020-12-30 | Oxygenator, oxygenator hollow fiber membrane woven assembly and forming method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011608907.8A CN112773961A (en) | 2020-12-30 | 2020-12-30 | Oxygenator, oxygenator hollow fiber membrane woven assembly and forming method thereof |
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| CN112773961A true CN112773961A (en) | 2021-05-11 |
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| CN202011608907.8A Pending CN112773961A (en) | 2020-12-30 | 2020-12-30 | Oxygenator, oxygenator hollow fiber membrane woven assembly and forming method thereof |
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| CN116271306A (en) * | 2023-05-24 | 2023-06-23 | 北京清瀚医疗科技有限公司 | Polygonal artificial membrane lung for in-vitro carbon dioxide removal and preparation method thereof |
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Application publication date: 20210511 |