CN112773946A - 神经外科术后防粘连膜及其制备方法 - Google Patents

神经外科术后防粘连膜及其制备方法 Download PDF

Info

Publication number
CN112773946A
CN112773946A CN202110206208.9A CN202110206208A CN112773946A CN 112773946 A CN112773946 A CN 112773946A CN 202110206208 A CN202110206208 A CN 202110206208A CN 112773946 A CN112773946 A CN 112773946A
Authority
CN
China
Prior art keywords
parts
silicon dioxide
adhesion membrane
dioxide aerogel
magnolol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110206208.9A
Other languages
English (en)
Inventor
徐高峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Affiliated Hospital of Medical College of Xian Jiaotong University
Original Assignee
First Affiliated Hospital of Medical College of Xian Jiaotong University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Affiliated Hospital of Medical College of Xian Jiaotong University filed Critical First Affiliated Hospital of Medical College of Xian Jiaotong University
Priority to CN202110206208.9A priority Critical patent/CN112773946A/zh
Publication of CN112773946A publication Critical patent/CN112773946A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/84—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from copolyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/428—Vitamins, e.g. tocopherol, riboflavin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明涉及医用材料领域，具体涉及一种神经外科术后防粘连膜及其制备方法,该防粘连膜由以下重量份的原料制备而成：生物基聚酯热塑性弹性体5～15份、聚乳酸20～30份、二氧化硅气凝胶7～13份、维生素B1 0.3～0.9份、神经生长因子（NGF）0.3～0.6份、厚朴酚0.1～0.3份、山奈酚0.1～0.3份、无水乙醇 10～20份。与现有技术相比，本发明所得的防粘连膜具有优良的防粘连以及促进神经修复效果，且自带消炎抗菌功能。

Description

神经外科术后防粘连膜及其制备方法
技术领域
本发明涉及医用材料领域，具体涉及一种神经外科术后防粘连膜及其制备方法。
背景技术
粘连是结缔组织纤维与相邻的组织或器官结合在一起而形成的异常结构，其大小可以从一片纤维的薄膜到稠密的血管疤痕。术后粘连是手术常见并发症之一。神经外科手术后的粘连除了涉及一般外科手术的粘连问题外还存在粘连组织或器官影响神经系统的问题。例如，手术治疗腰推间盘突出症是常见的治疗方法，其中一部分经手术达到治愈目的。然而仍有10％～21％的病人存在小腿外侧及足背部麻木不适感，神经根周围组织粘连受压是其主要原因。
此外，神经外科手术后，即使新鲜清洁的周围神经断裂伤，以及采用先进的显微外科技术进行修改，通常也不可能获得完全再生，功能也往往不能完全恢复。例如，应当显微缝合技术修复周围神经损伤是临床上主要的方法，但是单纯缝合后由于炎症反应等造成局部瘢痕组织增生粘连直接影响了神经修改的效果。显微缝合后神经缝合口出瘢痕组织的增生和局部与周围组织的粘连不仅影响局部的微循环，而且瘢痕早期可阻碍再生轴突向远端延伸，晚期又可能牵拉压迫神经吻合口，造成神经显微排列结构紊乱，妨碍神经功能的恢复。
近些年来，在术后容易发生粘连的部位植入隔离材料即防粘连材料，已成为国际上防止手术后粘连的通用做法，目前临床上常用聚乳酸钠预防术后粘连，但是由于其纯度不高、无消炎作用，用后效果不尽如人意；很多国家也曾尝试过用可吸收聚乳酸类固体材料来达到隔离创面并预防和减少粘连的目的，但其强度和刚度太强，柔韧性不足，因此防粘连效果也并不理想。
发明内容
为解决上述问题，本发明提供了一种神经外科术后防粘连膜及其制备方法，具有优良的防粘连效果，同时可以促进神经修复，具有消炎抗菌的功效。
为实现上述目的，本发明采取的技术方案为：
神经外科术后防粘连膜,由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体5～15份、聚乳酸20～30份、二氧化硅气凝胶7～13份、维生素B1 0.3～0.9份、神经生长因子（NGF）0.3～0.6份、厚朴酚0.1～0.3份、山奈酚0.1～0.3份、无水乙醇 10～20份。
进一步地，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体5份、聚乳酸20份、二氧化硅气凝胶7份、维生素B1 0.3份、神经生长因子（NGF）0.3份、厚朴酚0.1份、山奈酚0.1份、无水乙醇 10份。
进一步地，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体15份、聚乳酸30份、二氧化硅气凝胶13份、维生素B1 0.9份、神经生长因子（NGF）0.6份、厚朴酚0.3份、山奈酚0.3份、无水乙醇 20份。
进一步地，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体10份、聚乳酸25份、二氧化硅气凝胶10份、维生素B1 0.6份、神经生长因子（NGF）0.45份、厚朴酚0.2份、山奈酚0.2份、无水乙醇 15份。
本发明还提供了上述神经外科术后防粘连膜的制备方法,包括如下步骤：
S1、按上述的配方称取各组分；
S2、将所称取的生物基聚酯热塑性弹性体进行静电纺丝，并将所得的纺丝编织成三维交错网络结构特征的纤维毡结构；
S3、将所称取的维生素B1、神经生长因子（NGF）、厚朴酚、山奈酚溶于无水乙醇中，形成混合溶液；
S3、向所得的混合溶液中加入二氧化硅气凝胶，待二氧化硅气凝胶吸附完全后，喷涂在所得的纤维毡结构表面，使得纤维毡结构完全被包裹，干燥；
S4、喷涂聚乳酸层，使得纤维毡结构完全被包裹，即得防粘连膜。
进一步地，所述二氧化硅气凝胶为亲水性二氧化硅气凝胶。
与现有技术相比，本发明所得的防粘连膜具有优良的防粘连以及促进神经修复效果，且自带消炎抗菌功能。
具体实施方式
为了使本发明的目的及优点更加清楚明白，以下结合实施例对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
以下实施例中，所述二氧化硅气凝胶为亲水性二氧化硅气凝胶。
实施例1
一种神经外科术后防粘连膜，通过以下方法制备所得：
S1、按重量份称取：生物基聚酯热塑性弹性体5份、聚乳酸20份、二氧化硅气凝胶7份、维生素B1 0.3份、神经生长因子（NGF）0.3份、厚朴酚0.1份、山奈酚0.1份、无水乙醇 10份；
S2、将所称取的生物基聚酯热塑性弹性体进行静电纺丝，并将所得的纺丝编织成三维交错网络结构特征的纤维毡结构；
S3、将所称取的维生素B1、神经生长因子（NGF）、厚朴酚、山奈酚溶于无水乙醇中，形成混合溶液；
S3、向所得的混合溶液中加入二氧化硅气凝胶，待二氧化硅气凝胶吸附完全后，喷涂在所得的纤维毡结构表面，使得纤维毡结构完全被包裹，干燥；
S4、喷涂聚乳酸层，使得纤维毡结构完全被包裹，干燥，即得防粘连膜。
实施例2
一种神经外科术后防粘连膜，通过以下方法制备所得：
S1、按重量份称取：生物基聚酯热塑性弹性体15份、聚乳酸30份、二氧化硅气凝胶13份、维生素B1 0.9份、神经生长因子（NGF）0.6份、厚朴酚0.3份、山奈酚0.3份、无水乙醇20份；
S2、将所称取的生物基聚酯热塑性弹性体进行静电纺丝，并将所得的纺丝编织成三维交错网络结构特征的纤维毡结构；
S3、将所称取的维生素B1、神经生长因子（NGF）、厚朴酚、山奈酚溶于无水乙醇中，形成混合溶液；
S3、向所得的混合溶液中加入二氧化硅气凝胶，待二氧化硅气凝胶吸附完全后，喷涂在所得的纤维毡结构表面，使得纤维毡结构完全被包裹，干燥；
S4、喷涂聚乳酸层，使得纤维毡结构完全被包裹，干燥，即得防粘连膜。
实施例3
一种神经外科术后防粘连膜，通过以下方法制备所得：
S1、按重量份称取：生物基聚酯热塑性弹性体10份、聚乳酸25份、二氧化硅气凝胶10份、维生素B1 0.6份、神经生长因子（NGF）0.45份、厚朴酚0.2份、山奈酚0.2份、无水乙醇15份；
S2、将所称取的生物基聚酯热塑性弹性体进行静电纺丝，并将所得的纺丝编织成三维交错网络结构特征的纤维毡结构；
S3、将所称取的维生素B1、神经生长因子（NGF）、厚朴酚、山奈酚溶于无水乙醇中，形成混合溶液；
S3、向所得的混合溶液中加入二氧化硅气凝胶，待二氧化硅气凝胶吸附完全后，喷涂在所得的纤维毡结构表面，使得纤维毡结构完全被包裹，干燥；
S4、喷涂聚乳酸层，使得纤维毡结构完全被包裹，干燥，即得防粘连膜。
经验证，本发明所得的防粘连膜柔韧性佳，具有优良的防粘连以及促进神经修复效果，且自带消炎抗菌功能。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以作出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (6)

1.神经外科术后防粘连膜,其特征在于，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体5～15份、聚乳酸20～30份、二氧化硅气凝胶7～13份、维生素B1 0.3～0.9份、神经生长因子（NGF）0.3～0.6份、厚朴酚0.1～0.3份、山奈酚0.1～0.3份、无水乙醇 10～20份。
2.如权利要求1所述的神经外科术后防粘连膜,其特征在于，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体5份、聚乳酸20份、二氧化硅气凝胶7份、维生素B1 0.3份、神经生长因子（NGF）0.3份、厚朴酚0.1份、山奈酚0.1份、无水乙醇 10份。
3.如权利要求1所述的神经外科术后防粘连膜,其特征在于，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体15份、聚乳酸30份、二氧化硅气凝胶13份、维生素B1 0.9份、神经生长因子（NGF）0.6份、厚朴酚0.3份、山奈酚0.3份、无水乙醇 20份。
4.如权利要求1所述的神经外科术后防粘连膜,其特征在于，由以下重量份的原料制备而成：
生物基聚酯热塑性弹性体10份、聚乳酸25份、二氧化硅气凝胶10份、维生素B1 0.6份、神经生长因子（NGF）0.45份、厚朴酚0.2份、山奈酚0.2份、无水乙醇 15份。
5.神经外科术后防粘连膜的制备方法,其特征在于，包括如下步骤：
S1、按权利要求1～4任一项所述的配方称取各组分；
S2、将所称取的生物基聚酯热塑性弹性体进行静电纺丝，并将所得的纺丝编织成三维交错网络结构特征的纤维毡结构；
S3、将所称取的维生素B1、神经生长因子（NGF）、厚朴酚、山奈酚溶于无水乙醇中，形成混合溶液；
S3、向所得的混合溶液中加入二氧化硅气凝胶，待二氧化硅气凝胶吸附完全后，喷涂在所得的纤维毡结构表面，使得纤维毡结构完全被包裹，干燥；
S4、喷涂聚乳酸层，使得纤维毡结构完全被包裹，即得防粘连膜。
6.如权利要求5所述的神经外科术后防粘连膜的制备方法,其特征在于，所述二氧化硅气凝胶为亲水性二氧化硅气凝胶。
CN202110206208.9A 2021-02-24 2021-02-24 神经外科术后防粘连膜及其制备方法 Pending CN112773946A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110206208.9A CN112773946A (zh) 2021-02-24 2021-02-24 神经外科术后防粘连膜及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110206208.9A CN112773946A (zh) 2021-02-24 2021-02-24 神经外科术后防粘连膜及其制备方法

Publications (1)

Publication Number Publication Date
CN112773946A true CN112773946A (zh) 2021-05-11

Family

ID=75761859

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110206208.9A Pending CN112773946A (zh) 2021-02-24 2021-02-24 神经外科术后防粘连膜及其制备方法

Country Status (1)

Country Link
CN (1) CN112773946A (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070025724A (ko) * 2005-09-05 2007-03-08 주식회사 바이오레인 다층구조의 유착방지제
CN103110984A (zh) * 2013-02-20 2013-05-22 上海典范医疗科技有限公司 止血聚乳酸防粘连膜的制备方法
CN105617445A (zh) * 2016-02-17 2016-06-01 江苏知原药业有限公司 一种透明质酸医用敷料
CN106730041A (zh) * 2016-12-02 2017-05-31 西安交通大学医学院第附属医院 神经外科术后防粘连膜及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070025724A (ko) * 2005-09-05 2007-03-08 주식회사 바이오레인 다층구조의 유착방지제
CN103110984A (zh) * 2013-02-20 2013-05-22 上海典范医疗科技有限公司 止血聚乳酸防粘连膜的制备方法
CN105617445A (zh) * 2016-02-17 2016-06-01 江苏知原药业有限公司 一种透明质酸医用敷料
CN106730041A (zh) * 2016-12-02 2017-05-31 西安交通大学医学院第附属医院 神经外科术后防粘连膜及其制备方法

Similar Documents

Publication Publication Date Title
EP0998949B1 (de) Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung
US9555155B2 (en) Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
EP3404133B1 (en) Warp-knitted fabric and medical material
EP2114473B1 (en) Tendon or ligament bioprostheses and methods of making same
CA2422852C (en) Methods for treating a patient using a bioengineered flat sheet graft prostheses
DK1638615T3 (en) MEDICAL POLYHYDROXYALKANOATE TEXTILES AND FIBERS
US9017714B2 (en) Nerve regeneration-inducing tube
Guillaume et al. Emerging trends in abdominal wall reinforcement: bringing bio‐functionality to meshes
EP0773032A1 (en) Medical materials and manufacturing methods thereof
JP6105060B2 (ja) コラーゲン膜を生成するための方法およびその使用
AU2007265987A1 (en) Thin film multilocular structure comprising collagen, material for tissue regeneration containing the same and method for producing the same
CN111298205A (zh) 一种载药复合疝气补片
CN110665045B (zh) 一种妇产科用可吸收缝合线
ten Hallers et al. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue
Zhao et al. Duraplasty of PHBV/PLA/Col membranes promotes axonal regeneration by inhibiting NLRP3 complex and M1 macrophage polarization in rats with spinal cord injury
CN112773946A (zh) 神经外科术后防粘连膜及其制备方法
CN104667340A (zh) 可生物降解和生物活性的缝合线
Ziaee et al. Autologous fibrin sealant in tubeless percutaneous nephrolithotomy; a prospective study
KR20190012958A (ko) 폴리디옥시리보뉴클레오타이드가 코팅된 의료용 봉합사 및 그의 제조방법
Dadaci et al. Evaluation of the effectiveness of biodegradable electrospun caprolactoneand poly (lactic acid-?-caprolactone) nerve conduits for peripheral nerveregenerations in a rat sciatic nerve defect model
CN108853563B (zh) 一种可吸收缝合线的制备方法
Dong et al. Clinical management of dural defects: A review
US20100159046A1 (en) Minimal tissue attachment implantable materials
Mello et al. Late favorable results of duroplasty with biocellulose: clinical retrospective study of 20 cases
CN208464163U (zh) 一种医用缓释微粒缝合线

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210511

RJ01 Rejection of invention patent application after publication