CN112763482A - Substrate liquid supply device - Google Patents
Substrate liquid supply device Download PDFInfo
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- CN112763482A CN112763482A CN202110144897.5A CN202110144897A CN112763482A CN 112763482 A CN112763482 A CN 112763482A CN 202110144897 A CN202110144897 A CN 202110144897A CN 112763482 A CN112763482 A CN 112763482A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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Abstract
The invention relates to a substrate liquid supply device, which comprises a substrate bottle assembly, a substrate liquid conveying assembly and a damping assembly, wherein the substrate bottle assembly comprises a plurality of groups of substrate bottles, each group of substrate bottles comprises a plurality of substrate bottles, and bottle caps of each group of substrate bottles are connected into a whole through a cross beam; the substrate liquid conveying component comprises a plurality of three-way valves and a substrate liquid conveying pipe connected with the three-way valves, and each three-way valve comprises two inlets and one outlet; the damping assembly comprises a linear bearing, a guide rod connected with the linear bearing in a sliding mode, a fixing seat for fixing the linear bearing, a spring and a handle which are arranged on the side face of the fixing seat, a damping block fixed on the fixing seat through a guide pin and a side damping plate contacted with the surface of the damping block, wherein a groove for the spring to stretch into is formed in the damping block, and the fixing seat is fixedly connected with a connecting block arranged on a cross beam between bottle caps. The substrate liquid supply device of the application avoids pollution of a substrate liquid conveying pipeline when a substrate bottle is replaced.
Description
Technical Field
The application belongs to the technical field of medical instruments, and particularly relates to a substrate liquid supply device.
Background
Chemiluminescence analysis is carried out by catalyzing chemiluminescence by a catalyst and oxidizing chemiluminescence by an oxidant to form an excited intermediate, simultaneously emitting photons (hM) when the excited intermediate returns to a stable ground state, and measuring the quantum yield of light by a luminescence signal measuring instrument. In chemiluminescence analysis, a substrate solution provides a reaction environment and a catalyst for a chemical reaction and is used for exciting a chemiluminescent substance to emit light, the substrate solution is generally divided into a substrate solution A and a substrate solution B, the substrate solution A is firstly injected into a reactant which is cleaned and separated, and after full reaction, the substrate solution B is then injected, and at the moment, the chemiluminescent substance can emit light instantly.
The filling of the substrate liquid for chemiluminescence analysis is an important stage, and the monitoring of the liquid volume state of the substrate liquid can effectively ensure the sufficiency of the reaction conditions and obtain the correct test result. In a high-speed luminometer, the consumption of substrate liquid is high due to high testing speed, and the substrate liquid in a single bottle cannot meet the requirement, so that a plurality of bottles of substrate liquid are required to be used so as to effectively switch the substrate bottles. However, the substrate solution used in the current chemiluminescence device is inconvenient to replace, and the pipeline in the substrate bottle is easy to pollute when being randomly placed in the substrate solution replacing process, thereby influencing the detection result.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the substrate liquid supply device is provided for solving the technical problems that the substrate liquid used in the existing chemiluminescence equipment is inconvenient to replace, and the pipeline in the substrate bottle is randomly placed in the substrate liquid replacement process and is easy to pollute.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a substrate liquid supply device comprises a substrate bottle assembly, a substrate liquid conveying assembly and a damping assembly;
the substrate bottle assembly comprises a plurality of groups of substrate bottles for containing substrate liquid, each group of substrate bottles comprises a plurality of substrate bottles for containing the substrate liquid, and bottle caps of each group of substrate bottles are connected into a whole through a cross beam;
the substrate liquid conveying component comprises a plurality of three-way valves arranged above the substrate bottles, a substrate liquid conveying pipe connected with the three-way valves and with one end arranged in the substrate bottles, a controller in control connection with the three-way valves and a substrate pump for pumping substrate liquid in each substrate bottle; the three-way valve comprises two inlets and one outlet, the two inlets of the three-way valve are respectively connected with two substrate bottles for containing the same substrate liquid, one outlet of the three-way valve is used for outputting the substrate liquid through a substrate liquid conveying pipe, the outlet of the three-way valve is communicated with the inlet of the substrate pump, and the controller is used for controlling the three-way valve to be switched to be communicated with the other substrate bottle for containing the same substrate liquid when the liquid level in one of the substrate bottles is lower than a threshold value;
the damping assembly is used for controlling the heights of bottle caps of a group of substrate bottles and a substrate liquid conveying pipe which penetrates through the bottle caps and is connected with the bottle caps, and comprises a linear bearing, a guide rod which penetrates through the linear bearing and is in sliding connection with the linear bearing, an upper shaft seat and a lower shaft seat which are used for fixing the upper end and the lower end of the guide rod, a fixing seat for fixing the linear bearing, a spring and a handle which are arranged on the side face of the fixing seat, a damping block which is fixed on the fixing seat through a guide pin and a side damping plate which is in contact with the surface of the damping block, a groove for the spring to extend into is formed in the damping block, the side damping plate, the upper shaft seat and the lower shaft seat are fixed on a shell of the substrate liquid.
Preferably, the substrate bottle assembly comprises two groups of substrate bottles for holding the substrate liquid, each group of substrate bottles comprising two substrate bottles.
Preferably, the substrate bottles are internally provided with liquid level sensors connected with the controller, the liquid level sensors are used for detecting the liquid level in the substrate bottles, and when the liquid level in the substrate bottles is detected to be lower than a threshold value, the controller controls the three-way valve to be switched to be communicated with another substrate bottle containing the same substrate liquid.
Preferably, the substrate liquid supply device further comprises a substrate bottle loading assembly, the substrate bottle loading assembly comprises a bottle seat for loading a group of substrate bottles, a base for fixing the bottle seat and a pressing plate located above the bottle seat, a guide strip is formed on the outer edge of the upper side of the bottle seat, a guide groove is formed between the base and the pressing plate, and the guide strip is arranged in the guide groove in a sliding mode.
Preferably, a gap allowing the damping block to float freely is formed between the guide pin and the damping block.
Preferably, the left side and the right side of the fixed seat are both fixedly provided with two damping blocks through guide pins, and the surfaces of the two damping blocks are respectively contacted with the surfaces of two side damping plates fixedly arranged on the shell of the substrate liquid supply device.
Preferably, the number of the grooves on the spring and the damping block is at least two, and one spring is placed in each groove; the guide rod and the linear bearing are preferably at least two.
Preferably, the substrate liquid conveying pipe is a corrosion-resistant PTFE pipe, and a corrosion-resistant metal pipe is sleeved outside the PTFE pipe.
Preferably, the side of the bottle cap of the substrate bottle is provided with a vent hole.
Preferably, the substrate liquid supply device further comprises an alarm circuit for alarming when the liquid level in the substrate bottle is detected to be lower than a set threshold value.
The invention has the beneficial effects that:
the substrate liquid supply device comprises a substrate bottle assembly, a substrate liquid conveying assembly and a damping assembly, when one bottle of substrate liquid is used up, the other bottle of substrate liquid is switched to continue to finish the filling of the substrate liquid, the demand of the substrate liquid is met, the situation that the liquid cannot be sucked is avoided, and meanwhile, the substrate bottle can be replaced in the test process; when the substrate bottle is replaced, the bottle cap and the substrate liquid conveying pipe can be separated from the substrate bottle and kept at a certain height through the damping assembly, the bottle cap and the substrate liquid conveying pipe cannot slide from a high position, the substrate bottle can be conveniently drawn out of an instrument and replaced, and meanwhile pollution of a substrate liquid conveying pipeline in the substrate bottle replacing process is avoided.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
FIG. 1 is a schematic view showing the overall construction of a substrate liquid supply apparatus according to an embodiment of the present application;
FIG. 2 is an exploded view of a substrate liquid supply apparatus according to an embodiment of the present application;
FIG. 3 is a schematic view showing the construction of a damper assembly of the substrate liquid supply apparatus according to the embodiment of the present application;
FIG. 4 is an exploded view of a damper assembly of the substrate liquid supply apparatus in an embodiment of the present application;
FIG. 5 is a sectional view of a damper assembly of the substrate liquid supply apparatus according to the embodiment of the present application;
FIG. 6 is a schematic structural view of a substrate bottle loading assembly according to an embodiment of the present application;
figure 7 is a cross-sectional view of a substrate bottle loading assembly according to an embodiment of the present application.
The reference numbers in the figures are: 1-substrate bottle assembly, 101-substrate bottle, 102-bottle cap, 103-crossbeam, 2-substrate liquid conveying assembly, 201-three-way valve, 202-substrate liquid conveying pipe, 3-damping assembly, 301-linear bearing, 302-guide rod, 303-fixing seat, 304-spring, 305-handle, 306-guide pin, 307-damping block, 308-connecting block, 309-side damping plate, 310-upper shaft seat, 311-lower shaft seat, 4-substrate bottle loading assembly, 401-bottle seat, 4011-guide bar, 402-base and 403-pressing plate.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be considered limiting of the scope of the present application. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art through specific situations.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Examples
The embodiment provides a substrate liquid supply device, as shown in fig. 1 and fig. 2, comprising a substrate bottle assembly 1, a substrate liquid conveying assembly 2 and a damping assembly 3;
as shown in fig. 2 and fig. 6, the substrate bottle assembly 1 comprises a plurality of groups of substrate bottles 101 for containing substrate liquid, each group of substrate bottles comprises a plurality of substrate bottles 101 for containing substrate liquid, and bottle caps 102 of each group of substrate bottles are connected into a whole through a cross beam 103; the substrate bottle assembly 1 of the embodiment comprises two groups of substrate bottles for containing substrate liquid, each group of substrate bottles comprises two substrate bottles 101, the two substrate bottles 101 of each group of substrate bottles are respectively used for containing substrate liquid A and substrate liquid B, and the substrate liquid A and the substrate liquid B are used in a set and can be replaced at the same time; the two substrate bottles 101 of each group of substrate bottles can also be used for containing the same substrate liquid;
as shown in fig. 2, the substrate liquid delivery assembly 2 comprises a plurality of three-way valves 201 (two three-way valves 201 in this embodiment) disposed above the substrate bottles 101, a substrate liquid delivery pipe 202 connected to the three-way valves 201 and having one end disposed in the substrate bottles 101, a controller in control connection with the three-way valves 201, and a substrate pump for pumping the substrate liquid in each substrate bottle 101; the three-way valve 201 comprises two inlets and one outlet, the two inlets of the three-way valve 201 are respectively connected with two substrate bottles 101 for containing the same substrate liquid, one outlet of the three-way valve 201 is used for outputting the substrate liquid through a substrate liquid conveying pipe 202, the outlet of the three-way valve 201 is communicated with the inlet of the substrate pump, and the controller is used for controlling the three-way valve 201 to be switched to be communicated with the other substrate bottle 101 for containing the same substrate liquid when the liquid level in one substrate bottle 101 is lower than a threshold value; liquid level sensors connected with a controller are installed in the substrate bottles 101, the liquid level sensors are used for detecting the liquid levels in the substrate bottles 101, and when the liquid levels in the substrate bottles 101 are detected to be lower than a threshold value, the controller controls the three-way valve 201 to be switched to be communicated with another substrate bottle 101 containing the same substrate liquid;
the damper assembly 3 is used to control the height of the cap 102 of a group of substrate bottles and the substrate fluid delivery tube 202 extending through the cap 102 and connected to the cap 102, as shown in fig. 2, 3, 4 and 5, the damping assembly 3 includes a linear bearing 301, a guide rod 302 penetrating the linear bearing 301 and slidably connected to the linear bearing 301, an upper shaft seat 310 and a lower shaft seat 311 fixing the upper and lower ends of the guide rod 302, a fixing seat 303 fixing the linear bearing 301, a spring 304 and a handle 305 disposed on the side surface of the fixing seat 303, a damping block 307 fixed to the fixing seat 303 by a guide pin 306, and a side damping plate 309 contacting the surface of the damping block 307, a groove for the spring 304 to extend into is formed on the damping block 307, the side damping plate 309, the upper shaft seat 310 and the lower shaft seat 311 are fixed on the shell of the substrate liquid supply device, the fixed seat 303 is fixedly connected with a connecting block 308 arranged on the cross beam 103 between the bottle caps 102; when the substrate bottle 101 needs to be replaced, the three-way valve 201 is controlled by the controller to be switched to be not communicated with the substrate bottle 101 to be replaced, the fixed seat 303 is moved upwards along the guide rod 302 by pulling the handle 305 upwards, so that the cross beam 103 drives the bottle cap 102 and the substrate liquid conveying pipe 202 to move upwards, the bottle cap 102 and the substrate liquid conveying pipe 202 leave the substrate bottle 101, a certain pressure is applied to the contact surface of the side damping plate 309 and the damping block 307 through the compression of the spring 304, the position maintaining function of the fixed seat 303, the cross beam 103, the bottle cap 102 and the substrate liquid conveying pipe 202 is realized through the friction force of the contact surface of the side damping plate 309 and the damping block 307, and the whole damping assembly 3, the bottle cap 102 and the substrate liquid conveying pipe 202 do not slide; the side damping plate 309 and the damping block 307 are made of a material with good wear resistance, such as PTFE, POM, or the like.
Further, as shown in fig. 5, a gap for allowing the damping mass 307 to freely float is provided between the guide pin 306 and the damping mass 307, so that the damping mass 307 can freely float a certain distance in the compression direction of the spring 304, and the static friction force between the damping mass 307 and the side damping plate 309 can be adjusted by adjusting the compression amount of the spring 304.
Further, as shown in fig. 3 and 4, two damping blocks 307 are fixedly arranged on both left and right sides of the fixed base 303 through guide pins 306, and the surfaces of the two damping blocks 307 are respectively contacted with the surfaces of two side damping plates 309 fixedly arranged on the housing of the substrate liquid supply device.
Further, as shown in fig. 4, the number of the grooves on the spring 304 and the damping block 307 is preferably at least two, and one spring 304 is placed in each groove; the guide rods 302 and the linear bearings 301 are preferably at least two to maintain stable movement of the holders 303, the cross member 103, the bottle caps 102, and the substrate liquid supply tube 202.
Further, the substrate liquid supply apparatus of the present embodiment further includes a substrate bottle loading assembly 4, as shown in fig. 6 and 7, the substrate bottle loading assembly 4 includes a bottle seat 401 for loading a group of substrate bottles 101, a base 402 for fixing the bottle seat 401, and a pressing plate 403 located above the bottle seat 401, a guide strip 4011 is formed at an outer edge of an upper side of the bottle seat 401, a guide groove is formed between the base 402 and the pressing plate 403, and the guide strip 4011 is slidably disposed in the guide groove, so that the bottle seat 401 can perform a drawing action along the guide groove, and the substrate bottles 101 are conveniently replaced;
further, the substrate liquid conveying pipe 202 of the embodiment adopts a corrosion-resistant PTFE pipe, and the PTFE pipe is sleeved with a corrosion-resistant metal pipe (preferably a corrosion-resistant 316L stainless steel pipe), so that the PTFE pipe is not bent and tilted, the liquid suction depth can be controlled, and the air suction is avoided.
Further, the bottle cap 102 side of the substrate bottle 101 of the present embodiment is provided with the vent hole, which can ensure that the air pressure inside and outside the bottle is the same (prevent negative pressure from forming in the substrate bottle 101, which squashes the bottle and affects liquid suction), and can prevent foreign matters such as dust from falling into the substrate bottle 101.
Further, the substrate liquid supply device of the embodiment further comprises an alarm circuit, and the alarm circuit is used for giving an alarm when the liquid level in the substrate bottle 101 is detected to be lower than a set threshold value, so as to remind a worker to add the substrate liquid.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The substrate liquid supply device is characterized by comprising a substrate bottle assembly (1), a substrate liquid conveying assembly (2) and a damping assembly (3);
the substrate bottle assembly (1) comprises a plurality of groups of substrate bottles (101) for containing substrate liquid, each group of substrate bottles comprises a plurality of substrate bottles (101) for containing the substrate liquid, and bottle caps (102) of each group of substrate bottles are connected into a whole through a cross beam (103);
the substrate liquid conveying assembly (2) comprises a plurality of three-way valves (201) arranged above the substrate bottles (101), a substrate liquid conveying pipe (202) connected with the three-way valves (201) and with one end arranged in the substrate bottles (101), a controller in control connection with the three-way valves (201), and a substrate pump for pumping substrate liquid in each substrate bottle (101); the three-way valve (201) comprises two inlets and one outlet, the two inlets of the three-way valve (201) are respectively connected with two substrate bottles (101) used for containing the same substrate liquid, one outlet of the three-way valve (201) is used for outputting the substrate liquid through a substrate liquid conveying pipe (202), the outlet of the three-way valve (201) is communicated with the inlet of the substrate pump, and the controller is used for controlling the three-way valve (201) to be switched to be communicated with the other substrate bottle (101) containing the same substrate liquid when the liquid level in one of the substrate bottles (101) is lower than a threshold value;
the damping component (3) is used for controlling the heights of bottle caps (102) of a group of substrate bottles and a substrate liquid conveying pipe (202) which penetrates through the bottle caps (102) and is connected with the bottle caps (102), the damping component (3) comprises a linear bearing (301), a guide rod (302) which penetrates through the linear bearing (301) and is in sliding connection with the linear bearing (301), an upper shaft seat (310) and a lower shaft seat (311) which are used for fixing the upper end and the lower end of the guide rod (302), a fixing seat (303) for fixing the linear bearing (301), a spring (304) and a handle (305) which are arranged on the side surface of the fixing seat (303), a damping block (307) which is fixed on the fixing seat (303) through a guide pin (306), and a side damping plate (309) which is in contact with the surface of the damping block (307), a groove for the spring (304) to extend into is formed on the damping block (307), and the side damping plate (309), the upper shaft seat (310) and, the fixed seat (303) is fixedly connected with a connecting block (308) arranged on a cross beam (103) between the bottle caps (102).
2. The substrate liquid supply device according to claim 1, further comprising a substrate bottle loading assembly (4), wherein the substrate bottle loading assembly (4) comprises a bottle seat (401) for loading a group of substrate bottles (101), a base (402) for fixing the bottle seat (401), and a pressing plate (403) located above the bottle seat (401), a guide strip (4011) is formed at the outer edge of the upper side of the bottle seat (401), a guide groove is formed between the base (402) and the pressing plate (403), and the guide strip (4011) is slidably arranged in the guide groove.
3. A substrate supply apparatus according to claim 1 or 2, wherein said substrate bottle assembly (1) comprises two sets of substrate bottles for holding substrate liquid, each set comprising two substrate bottles (101).
4. The substrate liquid supply device according to claim 1 or 2, characterized in that a liquid level sensor connected with a controller is installed in each substrate bottle (101), the liquid level sensor is used for detecting the liquid level in the substrate bottle (101), and when the liquid level in the substrate bottle (101) is detected to be lower than a threshold value, the controller controls the three-way valve (201) to be switched to be communicated with another substrate bottle (101) containing the same substrate liquid.
5. The substrate liquid supply apparatus according to claim 1 or 2, wherein a clearance for allowing the damping mass (307) to float freely is provided between the guide pin (306) and the damping mass (307).
6. The substrate liquid supply device according to claim 1 or 2, wherein two damping blocks (307) are fixedly arranged on the left side and the right side of the fixed seat (303) through guide pins (306), and the surfaces of the two damping blocks (307) are respectively contacted with the surfaces of two side damping plates (309) fixedly arranged on the housing of the substrate liquid supply device.
7. A substrate supply apparatus according to claim 1 or claim 2, wherein the spring (304) and the damping mass (307) each have at least two recesses, one spring (304) being disposed in each recess.
8. The substrate supply apparatus according to claim 1 or 2, wherein the substrate transport pipe (202) is a corrosion-resistant PTFE pipe around which a corrosion-resistant metal pipe is sleeved.
9. The substrate liquid supply apparatus according to claim 1 or 2, wherein a gas-permeable hole is provided in a side surface of the cap (102) of the substrate bottle (101).
10. The substrate supply apparatus according to claim 1 or 2, further comprising an alarm circuit for alarming upon detection of a liquid level in the substrate bottle (101) below a set threshold.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110144897.5A CN112763482B (en) | 2021-02-03 | 2021-02-03 | Substrate liquid supply device |
| PCT/CN2021/081002 WO2022165925A1 (en) | 2021-02-03 | 2021-03-16 | Substrate liquid supply device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110144897.5A CN112763482B (en) | 2021-02-03 | 2021-02-03 | Substrate liquid supply device |
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| Publication Number | Publication Date |
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| CN112763482A true CN112763482A (en) | 2021-05-07 |
| CN112763482B CN112763482B (en) | 2022-08-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110144897.5A Active CN112763482B (en) | 2021-02-03 | 2021-02-03 | Substrate liquid supply device |
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| CN (1) | CN112763482B (en) |
| WO (1) | WO2022165925A1 (en) |
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| CN113815917A (en) * | 2021-10-28 | 2021-12-21 | 中元汇吉生物技术股份有限公司 | Substrate bottle replacement device, method for controlling same, and sample analyzer |
| CN113934236A (en) * | 2021-10-12 | 2022-01-14 | 中元汇吉生物技术股份有限公司 | Substrate device and substrate control system thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113934236A (en) * | 2021-10-12 | 2022-01-14 | 中元汇吉生物技术股份有限公司 | Substrate device and substrate control system thereof |
| CN113815917A (en) * | 2021-10-28 | 2021-12-21 | 中元汇吉生物技术股份有限公司 | Substrate bottle replacement device, method for controlling same, and sample analyzer |
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|---|---|
| WO2022165925A1 (en) | 2022-08-11 |
| CN112763482B (en) | 2022-08-09 |
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