CN112755106A

CN112755106A - Traditional Chinese medicine composition suitable for Tian moxibustion and preparation method thereof

Info

Publication number: CN112755106A
Application number: CN202110269006.9A
Authority: CN
Inventors: 胡晓波; 代媛媛; 吴莉萍; 张雪; 吴季; 王晓雨; 李静; 廖心悦; 陈望月
Original assignee: Chengdu Integrated TCM and Western Medicine Hospital,
Current assignee: Chengdu Integrated TCM and Western Medicine Hospital,
Priority date: 2021-03-12
Filing date: 2021-03-12
Publication date: 2021-05-07

Abstract

The invention discloses a traditional Chinese medicine composition suitable for Tian moxibustion and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 5-20 parts of semen brassicae, 5-20 parts of ephedra, 5-20 parts of asarum, 5-20 parts of rhizoma corydalis, 5-20 parts of long pepper, 5-20 parts of rhizoma acori graminei, 5-20 parts of rhizoma pinellinae praeparata, 5-20 parts of cinnamon, 5-20 parts of lumbricus, 5-20 parts of radix astragali, 5-20 parts of semen ginkgo, 5-20 parts of schisandra chinensis, 5-20 parts of rhizoma atractylodis and 5-20 parts of euphorbia kansui; the traditional Chinese medicine composition can effectively solve the problem of poor treatment effect of the existing Tian moxibustion traditional Chinese medicine composition in the aspects of treating asthma, allergic rhinitis and the like.

Description

Traditional Chinese medicine composition suitable for Tian moxibustion and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition suitable for moxibustion and a preparation method thereof.

Background

Bronchial asthma is a common respiratory disease, and is considered by modern medicine to be caused by the combined action of multiple factors, and the bronchial asthma often causes the stress reaction of mast cells and eosinophils, and causes symptoms such as airway hyperresponsiveness, allergic inflammation, reversible airway obstruction and the like. Clinically, hormone inhibitors, bronchodilators and the like are commonly used to inhibit the activity of inflammatory mediators, so that the aim of treatment is achieved. The western medicine treatment has the greatest characteristics of quick response, high recent curative effect, incapability of completely curing the diseases, high later-stage recurrence rate and inevitable adverse reactions caused by long-term hormone action.

The natural moxibustion therapy is mainly based on the traditional Chinese medicine theory of ' corresponding to the heaven and ' summer treatment of winter diseases ', utilizes the hot climate to assist the heaven yang of a human body, and can also promote the yang qi of the medicine to achieve the dredging function of warming yang and benefiting qi, thereby achieving the effects of dispelling cold evil, activating collaterals and blood qi, supplementing vital qi, regulating viscera and increasing physique, and achieving ' prevention before illness ' and ' prevention of change after illness '. Meanwhile, the moxibustion can make the medicine penetrate into subcutaneous tissues, and can improve the nonspecific immunity of organisms, adjust the immune function, reduce the allergic stimulation of the organisms, improve the function of an adrenal cortex system, reduce the sensitivity of respiratory tracts, relieve the spasm symptom of bronchial smooth muscles and accelerate the absorption of exudates by matching with acupuncture point treatment, thereby achieving the effect of preventing asthma. The heaven moxibustion therapy has wider and wider clinical application range, simple, convenient and quick method and safe use, and has the most typical advantages and characteristics of painless external treatment. Many studies show that the Tian moxibustion Chinese medicament is superior to western medicaments in preventing and treating bronchial asthma, so the Tian moxibustion Chinese medicament is accepted by patients more and more, and has huge market prospect.

However, the existing Chinese medicinal composition for three-volt day moxibustion has limited effect on chronic diseases such as asthma, allergic rhinitis and the like.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition suitable for Tian moxibustion and a preparation method thereof, and the traditional Chinese medicine composition can effectively solve the problem of poor treatment effect of the traditional Chinese medicine composition in the aspects of treating asthma, allergic rhinitis and the like.

In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:

a traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 5-20 parts of white mustard seed, 5-20 parts of ephedra, 5-20 parts of asarum, 5-20 parts of corydalis tuber, 5-20 parts of long pepper, 5-20 parts of grassleaf sweelflag rhizome, 5-20 parts of rhizoma pinellinae praeparata, 5-20 parts of cinnamon, 5-20 parts of earthworm, 5-20 parts of astragalus, 5-20 parts of ginkgo seed, 5-20 parts of Chinese magnoliavine fruit, 5-20 parts of rhizoma atractylodis and 5-20 parts of euphorbia kansui.

Further, the paint comprises the following components in parts by weight: 10 parts of white mustard seed, 10 parts of ephedra, 10 parts of asarum, 10 parts of corydalis tuber, 10 parts of long pepper, 10 parts of grassleaf sweelflag rhizome, 10 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of earthworm, 10 parts of astragalus root, 10 parts of ginkgo kernel, 10 parts of Chinese magnoliavine fruit, 10 parts of rhizoma atractylodis and 10 parts of euphorbia kansui.

Further, the white mustard seed is stir-fried.

Further, corydalis tuber is processed with vinegar.

Further, rhizoma Atractylodis is stir-baked with bran.

In the scheme, the white mustard seed is pungent and warm in property and enters the lung and stomach meridians. The stir-fried white mustard seed has the effects of warming the middle-jiao and dispelling cold, promoting qi circulation and reducing phlegm, and dredging collaterals and relieving pain, and has relatively small stimulation to the skin. The prescription is a monarch drug and is suitable for patients with rhinitis, chronic obstructive pulmonary disease and other respiratory system diseases with deficiency-cold constitution.

The ephedra herb is warm in nature, pungent and slightly bitter in taste, enters the lung channel, has the effects of inducing sweat, dispelling cold, relieving exterior syndrome, freeing lung, relieving asthma, inducing diuresis and reducing edema, is a holy medicine of the respiratory system, and is a ministerial medicine in the recipe.

Asarum herb, being pungent and warm, enters heart, lung and kidney meridians, has little toxicity, and has the main effects of expelling wind and clearing away cold, relieving stuffiness and pain, warming lung and resolving fluid retention. The prescription is a ministerial drug and is used for patients with rhinitis, chronic obstructive pulmonary disease and the like with deficiency-cold constitution.

The corydalis tuber is pungent, bitter and warm, has no toxicity, enters liver channel and stomach channel, and has the main effects of promoting blood circulation, regulating qi to alleviate pain and removing blood stasis. After vinegar processing, the pain relieving effect is enhanced, so the prescription has certain curative effect on deficiency-cold type dysmenorrhea, cold type abdominal pain and the like. The formula of the composition is used as an adjuvant.

After drawing: the long pepper is pungent and hot, and has the effects of warming middle-jiao to dispel cold, and expelling qi to alleviate pain. It is clinically used for abdominal pain, vomiting, diarrhea, coronary heart disease, angina pectoris, nervous headache and toothache caused by stomach cold.

Grassleaf sweelflag rhizome, rhizoma Acori Graminei is pungent, bitter and warm in nature, and mainly enters heart meridian and stomach meridian. Is an resuscitative, has the main functions of resolving dampness and stimulating appetite, inducing resuscitation and eliminating phlegm, refreshing mind and benefiting intelligence, and has good effects on skin diseases, digestive diseases and cardiovascular system diseases.

Rhizoma Pinelliae Preparata is processed product of rhizoma Pinelliae, is pungent in taste, and has effects of eliminating dampness and phlegm, relieving cough and asthma, lowering adverse qi and relieving vomit, relieving distension and fullness and resolving hard mass, etc., and it is used for treating diseases of spleen, stomach and lung.

Cinnamon is pungent, sweet and hot in nature, enters kidney, spleen and bladder channels, and has the effects of tonifying fire, supporting yang, guiding fire to origin, dispelling cold, relieving pain and warming and dredging channels and collaterals.

Earthworm is cold in nature, salty in taste, enters liver, stomach, lung and bladder channels, and has the functions of clearing heat and calming liver, extinguishing wind and relieving convulsion, relieving asthma and promoting urination, and dredging collaterals and removing arthralgia.

Astragalus root, radix astragali, being sweet and warm, enters lung and spleen channels, has the effects of invigorating qi and raising yang, expelling toxin and promoting granulation, and inducing diuresis and relieving swelling.

And (3) ginkgo kernel: sweet, bitter, astringent and mild, with little toxicity, entering lung meridian, and has the effects of astringing lung, relieving asthma, astringing and stopping leukorrhagia. It is often combined with Ma Huang, ban Xia and Su Zi.

The schisandra chinensis is sour and sweet in taste and warm in nature; it enters lung, heart and kidney meridians. Has effects in arresting sweating, tranquilizing mind, and resisting allergy. The schisandra fruit is added in the prescription to mainly treat asthma and allergic rhinitis.

Stir-baked rhizoma Atractylodis with bran, pungent, bitter and warm, entering spleen, stomach and liver meridians. Has effects in eliminating dampness, invigorating spleen, dispelling pathogenic wind, and dispelling cold.

Gan sui is bitter in flavor, cold in nature and toxic. It enters lung, spleen and stomach meridians. Being bitter and purging, cold can clear heat, and function to relieve constipation, it is a drastic herb for purging water and removing dampness, and can expel phlegm and purge retained fluid. It is mainly indicated for edema due to accumulation of dampness. In this formula, gan sui is used externally to expel phlegm and dispel fluid.

The stir-fried white mustard seed in the formula is pungent, warm, dry and strong, has the functions of warming lung and reducing phlegm, regulating qi and resolving masses, and dredging collaterals and relieving pain, and is a monarch drug. Ephedra herb, pinellia tuber, asarum, euphorbia kansui and the like warm the lung to dispel cold and relieve asthma, expel water and eliminate phlegm, and regulate the middle and remove dampness as the ministerial drugs. Rhizoma corydalis, cinnamon, earthworm, piper longum, rhizoma acori graminei, astragalus mongholicus, semen ginkgo, schisandra chinensis, fried rhizoma atractylodis and the like are used as adjuvants to achieve the effects of dredging collaterals, relieving pain, warming yang, relieving asthma, tonifying kidney and the like, so that the formula has a good treatment effect on refractory diseases such as asthma, allergic rhinitis and the like.

A preparation method of a traditional Chinese medicine composition suitable for Tian moxibustion comprises the following steps: pulverizing the above Chinese medicinal materials, mixing to obtain Chinese medicinal powder, and kneading with succus Zingiberis recens to obtain pill.

Further, the particle size of the Chinese medicinal powder is 80-120 meshes.

In the scheme, when the traditional Chinese medicine is used, the traditional Chinese medicine is ground into fine powder with the granularity of 80-120 meshes, when the fine powder is mixed with ginger juice, the effective components in the fine powder can be fully exuded and permeate into the body of a patient to play no therapeutic effect, if the granularity is too large, the effective components are incompletely exuded and too small, and the effective components are decomposed and destroyed in the grinding process, so that the therapeutic effect can be reduced when the granularity is too large or too small.

The beneficial effects produced by the invention are as follows:

the stir-fried white mustard seed in the formula is pungent, warm, dry and strong, has the functions of warming lung and reducing phlegm, regulating qi and resolving masses, and dredging collaterals and relieving pain, and is a monarch drug. Ephedra herb, pinellia tuber, asarum, euphorbia kansui and the like warm the lung to dispel cold and relieve asthma, expel water and eliminate phlegm, and regulate the middle and remove dampness as the ministerial drugs. Rhizoma corydalis, cinnamon, earthworm, piper longum, rhizoma acori graminei, astragalus mongholicus, semen ginkgo, schisandra chinensis, fried rhizoma atractylodis and the like are used as adjuvants to play the effects of dredging collaterals, relieving pain, warming yang, relieving asthma, tonifying kidney and the like, and the ginger juice is used as a guide, so that the formula has a better treatment effect on intractable diseases such as asthma, allergic rhinitis and the like.

Detailed Description

Example 1

A traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 20 parts of fried white mustard seed, 5 parts of ephedra, 5 parts of asarum, 10 parts of vinegar rhizoma corydalis, 10 parts of long pepper, 10 parts of rhizoma acori graminei, 5 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of earthworm, 10 parts of radix astragali, 10 parts of semen ginkgo, 5 parts of fructus schizandrae, 5 parts of bran-fried rhizoma atractylodis and 5 parts of euphorbia kansui.

A preparation method of a traditional Chinese medicine composition suitable for Tian moxibustion comprises the following steps: pulverizing the above Chinese medicinal materials into powder, mixing to obtain Chinese medicinal powder with particle size of 80 mesh, and kneading with ginger juice to obtain pill.

Example 2

A traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 10 parts of fried white mustard seed, 10 parts of ephedra, 10 parts of asarum, 20 parts of vinegar rhizoma corydalis, 5 parts of long pepper, 5 parts of rhizoma acori graminei, 5 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 0 part of earthworm, 10 parts of radix astragali, 20 parts of semen ginkgo, 20 parts of schisandra chinensis, 20 parts of bran-fried rhizoma atractylodis and 20 parts of euphorbia kansui.

A preparation method of a traditional Chinese medicine composition suitable for Tian moxibustion comprises the following steps: pulverizing the above Chinese medicinal materials into powder, mixing to obtain Chinese medicinal powder with particle size of 120 mesh, and kneading with ginger juice to obtain pill.

Example 3

A traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 10 parts of fried white mustard seed, 10 parts of ephedra, 10 parts of asarum, 10 parts of vinegar rhizoma corydalis, 10 parts of long pepper, 10 parts of rhizoma acori graminei, 10 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of earthworm, 10 parts of radix astragali, 10 parts of semen ginkgo, 10 parts of schisandra chinensis, 10 parts of bran-fried rhizoma atractylodis and 10 parts of euphorbia kansui.

A preparation method of a traditional Chinese medicine composition suitable for Tian moxibustion comprises the following steps: pulverizing the above Chinese medicinal materials into powder, mixing to obtain Chinese medicinal powder with particle size of 100 mesh, and kneading with ginger juice to obtain pill.

Comparative example 1

A traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 4 parts of white mustard seed, 4 parts of ephedra, 4 parts of asarum, 15 parts of corydalis tuber, 10 parts of long pepper, 25 parts of grassleaf sweelflag rhizome, 10 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of earthworm, 25 parts of astragalus, 10 parts of ginkgo kernel, 10 parts of Chinese magnoliavine fruit, 10 parts of rhizoma atractylodis and 25 parts of euphorbia kansui.

A preparation method of a traditional Chinese medicine composition suitable for Tian moxibustion, which is the same as example 3.

Comparative example 2

A traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 10 parts of fried white mustard seed, 10 parts of cassia twig, 10 parts of asarum, 10 parts of vinegar rhizoma corydalis, 10 parts of long pepper, 10 parts of rhizoma acori graminei, 10 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of zaocys dhumnade, 10 parts of radix astragali, 10 parts of semen ginkgo, 10 parts of gallnut, 10 parts of bran-fried rhizoma atractylodis and 10 parts of euphorbia kansui.

Comparative example 3

A traditional Chinese medicine composition suitable for Tian moxibustion comprises the following components in parts by weight: 10 parts of angelica dahurica, 10 parts of ephedra, 10 parts of asarum, 10 parts of vinegar rhizoma corydalis, 10 parts of long pepper, 10 parts of rhizoma acori graminei, 10 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of earthworm, 10 parts of radix codonopsitis, 10 parts of semen ginkgo, 10 parts of schisandra chinensis, 10 parts of bran-fried rhizoma atractylodis and 10 parts of euphorbia kansui.

Comparative example 4

A Chinese medicinal composition suitable for moxibustion, has the same formula as in example 3.

A preparation method of a traditional Chinese medicine composition suitable for Tian moxibustion comprises the following steps: pulverizing the above Chinese medicinal materials into powder, mixing to obtain Chinese medicinal powder with particle size of 60 mesh, and kneading with ginger juice to obtain pill.

Test examples

One, searching 140 adult patients suffering from asthma, randomly dividing into 7 groups, recording clinical symptoms of the patients, externally applying the pills prepared in examples 1-3 and comparative examples 1-4 to the 7 groups of patients respectively, applying the pills to Feishu, Xinshu, Geshu and Shenshu points of the patients by using medical adhesive tapes, wherein the application time is 4-6 hours each time, the uniform application time is 5 hours in the test example, the application is started on the first day of each vogue day, the application is started 1 time every 10 days, 3 vogue days, namely, head, two and three volts are used, the application is started every winter season, 1 time every 9 days, 3 nine days, namely, one nine, two nine and three nine days are used continuously, observing and recording the disease conditions of the patients, and counting the effective rate, wherein the specific results are shown in tables 1-2.

And (3) statistical standard:

the method has the following advantages: the patient's asthma symptoms disappear or are significantly reduced;

and (4) invalidation: the asthma symptoms of the patients have no obvious change;

statistics of effective rate

The effective rate is equal to the effective number of people/the total number of people multiplied by 100 percent

Table 1: statistics of treatment conditions

As can be seen from the above table, the Chinese medicinal composition of examples 1 to 3 of the present application has a better therapeutic effect, and particularly, the Chinese medicinal composition of example 3 has the best therapeutic effect.

Table 2: statistics of effective rate

	Number of people (human)	Number of valid persons (human)	Invalid number of people (human)	Effective rate (%)
					Example 1	20	18	2	90％
Example 2	20	17	3	85％
					Example 3	20	19	1	95％
Comparative example 1	20	5	15	25％
					Comparative example 2	20	4	16	20％
Comparative example 3	20	4	16	20％
					Comparative example 4	20	14	14	70％

As can be seen from the data in the table, the Chinese medicinal composition in the embodiments 1 to 3 of the application has a good treatment effect, and the effective rate of treatment is as high as 95%.

Secondly, 140 adult patients suffering from allergic rhinitis are searched and randomly divided into 7 groups, 20 patients in each group are recorded, pills prepared in examples 1-3 and comparative examples 1-4 are externally applied to the 7 groups of patients respectively, medical tapes are applied to Feishu, Xinshu, Geshu and Shenshu of the patients in the application process, the application time is generally 4-6 hours each time, the uniform application time in the test example is 5 hours, the application is started on the first day of each vogue, the application is started 1 time every 10 days, 3 vogues, namely, head voltage, two voltage and three voltage are used, the application is started from winter to winter, the disease condition is 1 time every 9 days, 3 nine days, namely, one nine, two nine and three nine, the three years are continuously used, the patient is observed and recorded, the statistical efficiency is carried out, and the specific result is shown in tables 3-4.

And (3) statistical standard:

the method has the following advantages: the rhinitis symptoms of the patient disappear or are obviously relieved;

and (4) invalidation: the rhinitis symptoms of the patients have no obvious change;

statistics of effective rate

Table 3: statistics of treatment conditions

As can be seen from the above table, the therapeutic effects of the Chinese medicinal compositions of examples 1 to 3 on allergic rhinitis are the best due to the therapeutic effects of comparative examples 1 to 4, particularly the therapeutic effect of example 3.

Table 4: statistics of effective rate

	Number of people (human)	Number of valid persons (human)	Invalid number of people (human)	Effective rate (%)
					Example 1	20	17	3	85％
Example 2	20	17	3	85％
					Example 3	20	19	1	95％
Comparative example 1	20	6	14	30％
					Comparative example 2	20	4	16	20％
Comparative example 3	20	4	16	20％
					Comparative example 4	20	15	5	75％

As can be seen from the data in the above table, the Chinese medicinal composition of the present application has a better therapeutic effect on allergic rhinitis, especially the Chinese medicinal composition of example 3 has the best therapeutic effect.

Comparing the comparative example 1 with the example 3, the proportion relationship of the components in the formula is changed, and the treatment results show that the Tian moxibustion composition in the comparative example 1 has poor treatment effect on allergic rhinitis and asthma, so that the dosage and proportion of the traditional Chinese medicinal materials in the traditional Chinese medicine formula of the application have great influence on the treatment effect.

Compared with the comparative example 2 and the example 3, the treatment effect of the Tian-moxibustion composition in the comparative example 2 on diseases is also deteriorated after the ephedra herb is replaced by the cassia twig, the earthworm is replaced by the zaocys dhumnade and the schisandra chinensis is replaced by the gallnut, and the fact that the components of the Tian-moxibustion composition in the application have mutual synergistic effect is proved, and the treatment effect is remarkably deteriorated after the medicinal taste is changed.

Comparing the comparative example 3 with the example 3, after the white mustard seed in the comparative example 3 is replaced by the dahurian angelica root and the astragalus root is replaced by the codonopsis pilosula, the treatment effect of the Tian-moxibustion composition in the comparative example 2 on diseases is also deteriorated, which proves that the components of the Tian-moxibustion composition in the application have mutual synergistic action, and the treatment effect is obviously deteriorated after the medicinal taste is changed.

Comparing comparative example 4 with example 3, the therapeutic effect is slightly deteriorated after changing the crushing particle size of the tianmoxibustive composition, which proves that the particle size in the application is more suitable for releasing the effective components in the medicinal materials.

Claims

1. The traditional Chinese medicine composition suitable for Tian moxibustion is characterized by comprising the following components in parts by weight: 5-20 parts of white mustard seed, 5-20 parts of ephedra, 5-20 parts of asarum, 5-20 parts of corydalis tuber, 5-20 parts of long pepper, 5-20 parts of grassleaf sweelflag rhizome, 5-20 parts of rhizoma pinellinae praeparata, 5-20 parts of cinnamon, 5-20 parts of earthworm, 5-20 parts of astragalus, 5-20 parts of ginkgo seed, 5-20 parts of Chinese magnoliavine fruit, 5-20 parts of rhizoma atractylodis and 5-20 parts of euphorbia kansui.

2. The traditional Chinese medicine composition suitable for natural moxibustion as claimed in claim 1, which comprises the following components in parts by weight: 10 parts of white mustard seed, 10 parts of ephedra, 10 parts of asarum, 10 parts of corydalis tuber, 10 parts of long pepper, 10 parts of grassleaf sweelflag rhizome, 10 parts of rhizoma pinellinae praeparata, 10 parts of cinnamon, 10 parts of earthworm, 10 parts of astragalus root, 10 parts of ginkgo kernel, 10 parts of Chinese magnoliavine fruit, 10 parts of rhizoma atractylodis and 10 parts of euphorbia kansui.

3. The traditional Chinese medicine composition suitable for moxibustion, according to claim 1, wherein white mustard seed is stir-fried.

4. The traditional Chinese medicine composition for moxibustion, as claimed in claim 1, wherein the corydalis tuber is processed with vinegar.

5. The traditional Chinese medicine composition suitable for moxibustion as claimed in claim 1, wherein the rhizoma atractylodis is stir-fried with bran.

6. The method for preparing a Chinese medicinal composition suitable for moxibustion as claimed in any one of claims 1-5, comprising the steps of: pulverizing the above Chinese medicinal materials, mixing to obtain Chinese medicinal powder, and kneading with succus Zingiberis recens to obtain pill.

7. The method of claim 6, wherein the particle size of the Chinese medicinal powder is 80-120 mesh.