CN112753777A - Milk powder for improving immunity and preparation method thereof - Google Patents

Milk powder for improving immunity and preparation method thereof Download PDF

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CN112753777A
CN112753777A CN202110113235.1A CN202110113235A CN112753777A CN 112753777 A CN112753777 A CN 112753777A CN 202110113235 A CN202110113235 A CN 202110113235A CN 112753777 A CN112753777 A CN 112753777A
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milk powder
powder
compound
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improving immunity
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刘鑫
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Peizhen Biotechnology Shanghai Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1322—Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A23C9/206—Colostrum; Human milk

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
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  • Molecular Biology (AREA)
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Abstract

The invention discloses milk powder for improving immunity, which belongs to the technical field of milk products and comprises the following raw materials: skimmed milk powder, whole milk powder, bovine colostrum powder, fructus Lycii powder, ganoderan, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-glucan, taurine, compound vitamins, compound minerals and compound probiotics; the preparation method comprises the following steps: (1) weighing the raw materials; (2) stirring fructus Lycii powder, Ganoderma polysaccharide, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-dextran and taurine, pulverizing and sieving; (3) adding skimmed milk powder, whole milk powder, bovine colostrum powder, compound vitamins, compound minerals and compound probiotics, and stirring. The raw materials are compounded and cooperated, so that the composition of carbohydrate is improved, the immune effect of milk powder is enhanced under the condition of not influencing the sensory characteristics, and the milk powder has a good activity function, can improve the physique of a user and enhance the immune resistance.

Description

Milk powder for improving immunity and preparation method thereof
Technical Field
The invention belongs to the technical field of milk products, and particularly relates to milk powder for improving immunity and a preparation method thereof.
Background
The milk powder is prepared from fresh milk or goat milk by freezing or heating to remove almost all water in milk, drying, adding appropriate amount of vitamins and minerals, and making into instant food suitable for storage. However, with the pace of life and the increase of life pressure, modern people generally have the states of malnutrition, low immunity, sub-health and the like, and the appropriate supplement of milk powder is very necessary.
Immunity is the body's own defense mechanism, and is the body's ability to recognize and destroy any foreign body (virus, bacteria, etc.) that invades from the outside, to treat aged, damaged, dead, denatured self cells, and to recognize and treat mutant cells and virus-infected cells in the body. The lack of endogenous peptide in human body can cause low immune function, the body presents an intolerant state due to the low immune function, cold viruses enter in a deficiency mode and are infected concurrently, particularly the infection concurrent with influenza has serious illness and high death rate. The body with low immunity is easy to be infected or suffer from cancer, and the body can have harmful results due to high immunity, such as anaphylaxis, autoimmune diseases and the like.
The immune system cannot normally exert protective effect due to various reasons, and in this case, the immune system is very easy to infect bacteria, viruses, fungi and the like, so the most direct expression of low immunity is easy to cause diseases. The frequent illness aggravates the consumption of the organism, so the general manifestations of weak constitution, malnutrition, listlessness, fatigue, weakness, appetite reduction, sleep disorder and the like, the disease is caused, injection and medication are carried out to get home and dinner, the disease can be recovered for a long time after each occurrence of the disease, and the disease is frequently repeated, the physical and intelligence development is poor for a long time, and serious diseases are easily induced.
The deep cause is hypoimmunity or poor immunity. When the human body is immune dysfunctional or the immune system is not healthy, the following problems are repeatedly caused: the cold attacks repeatedly, the tonsillitis attacks repeatedly, the asthma attacks repeatedly, the bronchitis attacks repeatedly, the pneumonia attacks repeatedly, and the diarrhea attacks repeatedly, so that tens of millions of people cannot see the eyes.
At present, the milk powder on the market is full of milk and has higher price, but the milk powder with the efficacy of improving immunity does not appear.
Therefore, the development of a milk powder which is convenient to eat and transport and has the function of improving immunity is a problem to be solved by the technical personnel in the field.
Disclosure of Invention
In view of the above, the present invention provides a milk powder for improving immunity.
In order to achieve the purpose, the invention adopts the following technical scheme:
the milk powder for improving immunity comprises the following raw materials in parts by weight: 400 portions of skimmed milk powder, 200 portions of whole milk powder, 50 to 100 portions of bovine colostrum powder, 20 to 40 portions of medlar powder, 10 to 20 portions of ganoderma lucidum polysaccharide, 10 to 15 portions of concentrated whey protein, 2 to 6 portions of lactose, 1 to 3 portions of galacto-oligosaccharide, 0.5 to 0.7 portion of lactoferrin, 0.3 to 1.1 portion of yeast beta-glucan, 0.3 to 0.5 portion of taurine, 0.1 to 0.3 portion of vitamin complex, 0.5 to 2 portions of compound mineral substances and 0.2 to 1 portion of compound probiotics.
Preferably: 500 parts of skimmed milk powder, 150 parts of whole milk powder, 80 parts of bovine colostrum powder, 30 parts of medlar powder, 15 parts of ganoderan, 12 parts of concentrated whey protein, 5 parts of lactose, 2 parts of galacto-oligosaccharide, 0.6 part of lactoferrin, 0.8 part of yeast beta-glucan, 0.4 part of taurine, 0.2 part of vitamin complex, 1.2 parts of compound mineral substances and 0.6 part of compound probiotics.
The invention has the beneficial effects that:
the skimmed milk powder has low fat content, is easy to digest, has the function of protecting intestines and stomach, but has unbalanced nutrient components; the whole milk powder has balanced nutrient components, and the protein clot is fine, soft and easy to digest; the invention combines the skim milk powder and the whole milk powder, so that the nutrient components of the milk powder are more balanced and easier to absorb.
The bovine colostrum powder contains a large amount of immune factors, and can enhance the immunity of human bodies and reduce the occurrence of intestinal diseases.
The medlar is sweet in nature and mild in taste, enters liver and kidney channels, has the effects of nourishing liver and kidney, nourishing liver and improving eyesight, and is proved by modern medical research to contain carotene, betaine, vitamin A, vitamin B1, vitamin B2, vitamin C, calcium, phosphorus, iron and the like, has the pharmacological effects of increasing the activity of white blood cells and promoting the regeneration of liver cells, and also can reduce blood pressure, blood sugar and blood fat; importantly, the medlar has the function of enhancing nonspecific immunity, and the mice are infused with medlar water extract or intramuscular injection alcohol extract and medlar polysaccharide, so that the phagocytic function of macrophages is improved, the function of serum lysozyme is enhanced, the titer of anti-sheep red blood cell antibodies in serum is improved, and the number of anti-sheep red blood cell antibody forming cells in spleen of the mice can be increased.
Ganoderan is a glucan composed of three strands of monosaccharide chains and having a helical three-dimensional structure (tertiary structure), wherein most of the ganoderan contains monosaccharides such as arabinose, xylose, galactose, fucose, mannose, rhamnose and the like besides glucose; the ganoderan can improve the immunity of organisms, has special physiological activity and clinical effect, is safe and nontoxic, and can inhibit the release of an allergic reaction medium so as to block the occurrence of nonspecific reaction.
The concentrated whey protein can modify the protein structure, thereby greatly reducing the amount of antigen active substances and reducing the occurrence of atopic inflammation.
The beta-disaccharide in the lactose has a good regulating effect on the intestinal tract, is beneficial to the reproduction of beneficial flora such as lactobacillus in the intestinal tract, inhibits the growth of harmful flora in the intestinal tract, has a regulating effect on the digestive system of a human body, is beneficial to the health of the intestinal tract, simultaneously produces rich B vitamins, is beneficial to promoting the peristalsis of the intestinal tract and increasing the immunity of the human body.
The galactooligosaccharide is an excellent nutrient source and an effective proliferation factor of beneficial bacteria such as bifidobacterium, lactobacillus acidophilus and the like in human intestinal tracts, and can improve the digestion and absorption functions of the human intestines and stomach.
Lactoferrin not only participates in the transport of iron, but also has the powerful biological functions of broad-spectrum antibiosis, antioxidation, anticancer, immune system regulation and the like.
The yeast beta-glucan is a polysaccharide which exists in yeast cell walls and has the activity of enhancing immunity, is widely present in various fungi and plants, has strong immunity enhancing activity, and has the effects of improving blood fat, removing toxins, resisting radiation, repairing cells and improving intestinal functions.
Taurine has effects of regulating in vivo osmotic pressure, lowering blood sugar, and improving immunity.
Further, the above-mentioned vitamin complex is at least one of sodium L-ascorbate, dl-alpha-tocopheryl acetate, vitamin A acetate, cholecalciferol and pyridoxine hydrochloride.
The further technical scheme has the beneficial effects that the compound vitamin is added, so that the normal growth, reproduction and vision can be maintained, the epithelial tissue is promoted to be healthy, and the anti-infection immune function is enhanced; can prevent rickets and promote calcium absorption; can prevent the peroxidation of unsaturated fatty acid in milk powder and protect skin, and the addition of compound vitamin can improve immunity and protect intestines and stomach.
Further, the compound mineral is ferric pyrophosphate and/or zinc sulfate.
The beneficial effect of the further technical proposal is that zinc and iron participate in the synthesis and activation of various enzymes, and play an important role in the synthesis of protein nucleic acid and the digestion and absorption of intestinal protein.
Further, the composite probiotics are animal bifidobacteria and/or lactobacillus acidophilus; further, the Bifidobacterium animalis has a bacterial content of 1X 106-1×108CFU/g, the bacteria content of Lactobacillus acidophilus is 1 × 106-1×108CFU/g。
The beneficial effects of the further technical scheme are that the bifidobacteria can produce lactic acid and acetic acid after fermentation in human intestines, can improve the utilization rate of calcium, phosphorus and iron and promote the absorption of iron and vitamin D, and can produce vitamins B1, B2, B6 and B12, alanine, valine, aspartic acid, threonine and other nutrients necessary for human bodies.
The lactobacillus acidophilus can adjust the flora balance in intestinal tracts and inhibit the proliferation of undesirable microorganisms in the intestinal tracts, and the lactobacillus acidophilus and the bifidobacterium are mixed to form a leavening agent, so that lactic acid and acetic acid are produced after fermentation in the intestinal tracts, the utilization rate of calcium, phosphorus and iron can be improved, the absorption of iron and vitamins can be promoted, vitamin K and vitamin B are produced, the absorption of cholesterol can be reduced, the function of inhibiting the growth of harmful bacteria is realized, the dysbacteriosis in vivo can be regulated, the generation of toxin in vivo can be reduced, and the detoxification burden of livers is reduced.
The invention also provides a preparation method of the milk powder for improving immunity, which comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the milk powder for improving immunity;
(2) stirring fructus Lycii powder, ganoderan, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-glucan and taurine, mixing well, pulverizing, and sieving to obtain premixed powder;
(3) adding skimmed milk powder, whole milk powder, bovine colostrum powder, compound vitamins, compound minerals and compound probiotics into the premixed powder, and stirring to mix well to obtain the milk powder for improving immunity.
The invention has the beneficial effects that:
the preparation method has simple process, easy operation and low production cost, and is suitable for wide production and application.
Further, in the step (2), the preparation method of the ganoderma lucidum polysaccharide comprises the following steps:
A. cleaning Ganoderma encarpium, drying to constant weight, crushing, and sieving with 100-mesh and 200-mesh sieve to obtain Ganoderma powder;
B. adding 6-8 times of anhydrous ethanol into Ganoderma powder, stirring for 1-2 hr, filtering, and collecting residue;
C. adding 6-8 times of distilled water and 1% -5% of cellulase by mass into ganoderma lucidum filter residue, stirring for 2-3h, filtering, collecting filtrate, concentrating under reduced pressure, precipitating with alcohol, washing with anhydrous ethanol, and purifying to obtain the ganoderma lucidum polysaccharide.
Further, in the step (2), the stirring speed is 80-120r/min, and the time is 10-20 min.
The beneficial effects of the further technical scheme are that: the accurate stirring parameters ensure that the raw materials are uniformly mixed, and the quality of the premixed powder product is uniform and stable.
Furthermore, in the step (2), the mesh number of the sieve is 100-200 meshes.
The beneficial effects of the further technical scheme are that: the raw materials are crushed, so that the milk powder has fine quality, the mouthfeel is enhanced, and the nutrient components are easier to be absorbed by a human body.
Further, in the step (3), the stirring speed is 50-100r/min, and the time is 20-30 min.
The beneficial effects of the further technical scheme are that: the accurate mixing parameters enable the raw materials to be uniformly mixed, and the milk powder product for improving the immunity has uniform and stable quality.
In summary, compared with the prior art, the invention has the following beneficial effects:
the raw materials are compounded and cooperated, and various nutrient elements necessary for human bodies are added, so that the milk powder is rich in protein and nutrition, particularly, the medlar powder and the ganoderma lucidum polysaccharide are added, the composition of carbohydrate is improved under the condition of not influencing the sensory characteristics, the immune effect of the milk powder is enhanced, the milk powder has good activity function, the physique of a user can be improved, and the immunity resistance is enhanced.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The milk powder for improving immunity comprises the following raw materials by weight: 400kg of skimmed milk powder, 100kg of whole milk powder, 50kg of bovine colostrum powder, 20kg of Chinese wolfberry powder, 10kg of ganoderma lucidum polysaccharide, 10kg of concentrated whey protein, 2kg of lactose, 1kg of galacto-oligosaccharide, 0.5kg of lactoferrin, 0.3kg of yeast beta-glucan, 0.3kg of taurine, 0.1kg of vitamin complex, 0.5kg of compound mineral substances and 0.2kg of compound probiotics;
wherein 0.1kg of the compound vitamin contains 0.012kg of L-ascorbic acid sodium, 0.018kg of dl-alpha-tocopherol acetate, 0.020kg of vitamin A acetate, 0.025kg of cholecalciferol and 0.025kg of pyridoxine hydrochloride;
0.5kg of composite mineral contains 0.3kg of ferric pyrophosphate and 0.2kg of zinc sulfate;
0.2kg of composite probiotics contains 1 × 10 bacteria80.1kg of Bifidobacterium animalis per gram and 1 × 10 bacteria content80.1kg of Lactobacillus acidophilus of CFU/g；
The preparation method of the milk powder for improving immunity comprises the following steps:
(1) weighing the raw materials according to the weight of the milk powder for improving immunity;
(2) stirring fructus Lycii powder, Ganoderma polysaccharide, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-dextran and taurine at 80r/min for 20min, mixing well, pulverizing, and sieving with 100 mesh sieve to obtain premixed powder;
the preparation method of the ganoderma lucidum polysaccharide comprises the following steps: A. cleaning Ganoderma encarpium, oven drying to constant weight, crushing, and sieving with 100 mesh sieve to obtain Ganoderma powder; B. adding absolute ethyl alcohol with the mass being 6 times that of the ganoderma lucidum powder, stirring for 1 hour, filtering, and collecting filter residues; C. adding 6 times of distilled water and 1% of cellulase by mass into the ganoderma lucidum filter residue, stirring for 2h, filtering, collecting the filtrate, concentrating under reduced pressure, precipitating with alcohol, washing with anhydrous ethanol, and purifying to obtain ganoderma lucidum polysaccharide;
(3) adding skimmed milk powder, whole milk powder, bovine colostrum powder, compound vitamins, compound minerals and compound probiotics into the premixed powder, and stirring at a speed of 50r/min for 30min until the mixture is uniform to obtain the milk powder for improving immunity.
Example 2
The milk powder for improving immunity comprises the following raw materials by weight: 500kg of skimmed milk powder, 150kg of whole milk powder, 80kg of bovine colostrum powder, 30kg of Chinese wolfberry powder, 15kg of ganoderma lucidum polysaccharide, 12kg of concentrated whey protein, 5kg of lactose, 2kg of galacto-oligosaccharide, 0.6kg of lactoferrin, 0.8kg of yeast beta-glucan, 0.4kg of taurine, 0.2kg of vitamin complex, 1.2kg of compound mineral substances and 0.6kg of compound probiotics;
wherein 0.2kg of the compound vitamin comprises 0.024kg of L-sodium ascorbate, 0.036kg of dl-alpha-tocopherol acetate, 0.040kg of vitamin A acetate, 0.050kg of cholecalciferol and 0.050kg of pyridoxine hydrochloride;
1.2kg of the compound mineral comprises 0.8kg of ferric pyrophosphate and 0.4kg of zinc sulfate;
0.6kg of composite probiotics contains 1 × 10 bacteria80.3kg of Bifidobacterium animalis per gram and 1 × 10 bacteria content8CFU/g Lactobacillus acidophilus 0.3kg；
The preparation method of the milk powder for improving immunity comprises the following steps:
(1) weighing the raw materials according to the weight of the milk powder for improving immunity;
(2) stirring fructus Lycii powder, Ganoderma polysaccharide, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-dextran and taurine at 100r/min for 15min, mixing well, pulverizing, and sieving with 150 mesh sieve to obtain premixed powder;
the preparation method of the ganoderma lucidum polysaccharide comprises the following steps: A. cleaning Ganoderma encarpium, oven drying to constant weight, crushing, and sieving with 150 mesh sieve to obtain Ganoderma powder; B. adding 7 times of anhydrous ethanol into Ganoderma powder, stirring for 1.5 hr, filtering, and collecting residue; C. adding 7 times of distilled water and 3% of cellulase by mass into the ganoderma lucidum filter residue, stirring for 2.5h, filtering, collecting the filtrate, concentrating under reduced pressure, precipitating with alcohol, washing with anhydrous ethanol, and purifying to obtain ganoderma lucidum polysaccharide;
(3) adding skimmed milk powder, whole milk powder, bovine colostrum powder, compound vitamins, compound minerals and compound probiotics into the premixed powder, and stirring at 80r/min for 25min to mix uniformly to obtain the milk powder for improving immunity.
Example 3
The milk powder for improving immunity comprises the following raw materials by weight: 600kg of skimmed milk powder, 200kg of whole milk powder, 100kg of bovine colostrum powder, 40kg of Chinese wolfberry powder, 20kg of ganoderma lucidum polysaccharide, 15kg of concentrated whey protein, 6kg of lactose, 3kg of galacto-oligosaccharide, 0.7kg of lactoferrin, 1.1kg of yeast beta-glucan, 0.5kg of taurine, 0.3kg of vitamin complex, 2kg of compound mineral substances and 1kg of compound probiotics;
wherein 0.3kg of the compound vitamin contains 0.036kg of L-sodium ascorbate, 0.054kg of dl-alpha-tocopherol acetate, 0.060kg of vitamin A acetate, 0.075kg of cholecalciferol and 0.075kg of pyridoxine hydrochloride;
2kg of the compound mineral contains 1.2kg of ferric pyrophosphate and 0.8kg of zinc sulfate;
1kg of composite probiotics contains 1 x 10 bacteria80.5kg of Bifidobacterium animalis per gram and 1 × 10 bacteria content8CFU/g Lactobacillus acidophilus 0.5kg；
The preparation method of the milk powder for improving immunity comprises the following steps:
(1) weighing the raw materials according to the weight of the milk powder for improving immunity;
(2) stirring fructus Lycii powder, ganoderan, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-glucan and taurine at 120r/min for 10min, mixing well, pulverizing, and sieving with 200 mesh sieve to obtain premixed powder;
the preparation method of the ganoderma lucidum polysaccharide comprises the following steps: A. cleaning Ganoderma encarpium, oven drying to constant weight, crushing, and sieving with 200 mesh sieve to obtain Ganoderma powder; B. adding absolute ethyl alcohol with the mass being 8 times that of the ganoderma lucidum powder, stirring for 2 hours, filtering, and collecting filter residues; C. adding 8 times of distilled water and 5% of cellulase by mass into the ganoderma lucidum filter residue, stirring for 3h, filtering, collecting the filtrate, concentrating under reduced pressure, precipitating with alcohol, washing with anhydrous ethanol, and purifying to obtain ganoderma lucidum polysaccharide;
(3) adding skimmed milk powder, whole milk powder, bovine colostrum powder, compound vitamins, compound minerals and compound probiotics into the premixed powder, and stirring at 100r/min for 20min until mixing uniformly to obtain the milk powder for improving immunity.
Comparative example 1
The milk powder for improving immunity is different from the milk powder in example 2 only in that the medlar powder is not contained.
Comparative example 2
The milk powder for improving immunity is different from the milk powder in example 2 only in that no ganoderan is contained.
Performance testing
1. Analysis of nutrient composition
The milk powders with improved immunity prepared in examples 1-3 were analyzed for their nutritional components, and the average values of the individual components are shown in Table 1.
TABLE 1 nutrient profile of milk powder of examples 1-3
Figure BDA0002919838480000091
Figure BDA0002919838480000101
As can be seen from Table 1, the milk powder for improving immunity prepared in the embodiments 1-3 of the present invention has various nutritional indexes meeting the corresponding requirements, and can meet the daily needs of human body.
2. Efficacy test
60 male KM mice (provided by Shanghai Slek laboratory animals, Inc.) at 5-6 weeks of age were collected and divided into 6 groups on average. Wherein, the 1 st to 5 th groups are respectively drenched with sterile water containing dissolved milk powder of examples 1 to 3 and comparative examples 1 to 2, and the 6 th group (blank control group) is drenched with sterile water with the same volume for 1 time every day for 30 days.
Each group was injected intraperitoneally with 1mL of 5% chicken red blood cell suspension on day 38 of the experiment. After 30min, the mice were sacrificed by cervical dislocation. lmL physiological saline was injected into the abdominal cavity, the abdomen of the mouse was gently kneaded for 1 minute, the skin of the abdominal wall was cut, the upper opening of the muscle layer was made, and the abdominal cavity fluid lmL was sucked up by inserting a pipette into the abdominal cavity and dropped on a clean slide glass. The slides were placed in an enamel box lined with wet gauze and then incubated in a 37 ℃ incubator for 30 minutes. And taking out the glass slide, rinsing to remove the supernatant and the cells which are not adhered to the glass slide, then drying at room temperature, fixing with a 1:1 acetone/methanol solution, placing in a Giemsa staining solution, carrying out dip staining for 15-30min, then washing with water and drying in the air. Macrophages were counted under high power microscope, 100 per slide, and percent phagocytosis and index of phagocytosis were calculated, respectively, and the results are shown in table 2.
Wherein the percent (%) phagocytosis is the number of macrophages that phagocytose chicken red blood cells/number of macrophages counted × 100; phagocytosis index is the total number of chicken erythrocytes phagocytosed per number of macrophages counted.
TABLE 2 Effect of groups of samples on phagocytic function of mouse macrophages
Group of Percentage of phagocytosis (%) Phagocytic index
Blank control group 32.5 0.41
Example 1 53.2 0.61
Example 2 55.1 0.63
Example 3 50.8 0.58
Comparative example 1 38.6 0.46
Comparative example 2 40.5 0.49
As can be seen from Table 2, the percent phagocytosis and the phagocytosis index of examples 1-3 of the present invention were significantly higher than those of the blank control and comparative examples 1-2.
The tests show that the milk powder can obviously improve the phagocytic function of mouse abdominal cavity macrophages, and the effect is superior to that of a comparative example.
The description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (10)

1. The milk powder for improving immunity is characterized by comprising the following raw materials in parts by weight: 400 portions of skimmed milk powder, 200 portions of whole milk powder, 50 to 100 portions of bovine colostrum powder, 20 to 40 portions of medlar powder, 10 to 20 portions of ganoderma lucidum polysaccharide, 10 to 15 portions of concentrated whey protein, 2 to 6 portions of lactose, 1 to 3 portions of galacto-oligosaccharide, 0.5 to 0.7 portion of lactoferrin, 0.3 to 1.1 portion of yeast beta-glucan, 0.3 to 0.5 portion of taurine, 0.1 to 0.3 portion of vitamin complex, 0.5 to 2 portions of compound mineral substances and 0.2 to 1 portion of compound probiotics.
2. The milk powder for improving immunity according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 500 parts of skimmed milk powder, 150 parts of whole milk powder, 80 parts of bovine colostrum powder, 30 parts of medlar powder, 15 parts of ganoderan, 12 parts of concentrated whey protein, 5 parts of lactose, 2 parts of galacto-oligosaccharide, 0.6 part of lactoferrin, 0.8 part of yeast beta-glucan, 0.4 part of taurine, 0.2 part of vitamin complex, 1.2 parts of compound mineral substances and 0.6 part of compound probiotics.
3. The milk powder for improving immunity according to claim 1 or 2, wherein the vitamin complex is at least one of sodium L-ascorbate, dl-alpha-tocopheryl acetate, vitamin A acetate, cholecalciferol and pyridoxine hydrochloride.
4. The milk powder for improving immunity according to claim 1 or 2, wherein the compound mineral is ferric pyrophosphate and/or zinc sulfate.
5. The milk powder for improving immunity according to claim 1 or 2, wherein the complex probiotics are animal bifidobacteria and/or lactobacillus acidophilus;
the strain content of Bifidobacterium animalis is 1 × 106-1×108CFU/g；
The bacteria content of the lactobacillus acidophilus is 1 multiplied by 106-1×108CFU/g。
6. The preparation method of the milk powder for improving immunity is characterized by comprising the following steps:
(1) weighing the raw materials according to the parts by weight of the milk powder for improving immunity of any one of claims 1 to 3;
(2) stirring fructus Lycii powder, ganoderan, concentrated lactalbumin, lactose, galactooligosaccharide, lactoferrin, yeast beta-glucan and taurine, mixing well, pulverizing, and sieving to obtain premixed powder;
(3) adding skimmed milk powder, whole milk powder, bovine colostrum powder, compound vitamins, compound minerals and compound probiotics into the premixed powder, and stirring to mix uniformly to obtain the milk powder for improving immunity.
7. The method for preparing milk powder for improving immunity according to claim 6, wherein in the step (2), the method for preparing ganoderan comprises the following steps:
A. cleaning Ganoderma encarpium, drying to constant weight, crushing, and sieving with 100-mesh and 200-mesh sieve to obtain Ganoderma powder;
B. adding 6-8 times of anhydrous ethanol into Ganoderma powder, stirring for 1-2 hr, filtering, and collecting residue;
C. adding 6-8 times of distilled water and 1% -5% of cellulase by mass into ganoderma lucidum filter residue, stirring for 2-3h, filtering, collecting filtrate, concentrating under reduced pressure, precipitating with alcohol, washing with anhydrous ethanol, and purifying to obtain the ganoderma lucidum polysaccharide.
8. The method for preparing milk powder with improved immunity according to claim 6, wherein in step (2), the stirring speed is 80-120r/min and the stirring time is 10-20 min.
9. The method as claimed in claim 6, wherein in step (2), the mesh number of the sieved mesh is 100-200 meshes.
10. The method for preparing milk powder with improved immunity according to claim 6, wherein in step (3), the stirring speed is 50-100r/min and the stirring time is 20-30 min.
CN202110113235.1A 2021-01-27 2021-01-27 Milk powder for improving immunity and preparation method thereof Pending CN112753777A (en)

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CN114145352A (en) * 2021-11-30 2022-03-08 广州麦乐生物科技有限公司 Adult formula milk powder for preventing cancer and preparation method and application thereof
CN114732051A (en) * 2022-03-10 2022-07-12 广州麦乐生物科技有限公司 Adult formula milk powder for reconstructing and strengthening human body immunity

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CN104982534A (en) * 2015-05-08 2015-10-21 苏州葛家坞生物科技有限公司 Ganoderma lucidum polysaccharide-containing infant formula milk powder
CN111011522A (en) * 2020-02-27 2020-04-17 青岛索康食品有限公司 Children formula milk powder capable of improving immunity and preparation method thereof
CN111758792A (en) * 2020-07-27 2020-10-13 广州班护生物科技有限公司 Milk powder for improving resistance and promoting growth and production method thereof
CN112244095A (en) * 2020-10-22 2021-01-22 成都诺臻生物科技有限公司 Milk powder for regulating immunity and preparation method thereof

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CN102499291A (en) * 2011-12-28 2012-06-20 内蒙古伊利实业集团股份有限公司 Milk powder with functions of maintaining beauty and keeping young and improving immunity of organism and preparation method thereof
CN104982534A (en) * 2015-05-08 2015-10-21 苏州葛家坞生物科技有限公司 Ganoderma lucidum polysaccharide-containing infant formula milk powder
CN111011522A (en) * 2020-02-27 2020-04-17 青岛索康食品有限公司 Children formula milk powder capable of improving immunity and preparation method thereof
CN111758792A (en) * 2020-07-27 2020-10-13 广州班护生物科技有限公司 Milk powder for improving resistance and promoting growth and production method thereof
CN112244095A (en) * 2020-10-22 2021-01-22 成都诺臻生物科技有限公司 Milk powder for regulating immunity and preparation method thereof

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* Cited by examiner, † Cited by third party
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CN114145352A (en) * 2021-11-30 2022-03-08 广州麦乐生物科技有限公司 Adult formula milk powder for preventing cancer and preparation method and application thereof
CN114732051A (en) * 2022-03-10 2022-07-12 广州麦乐生物科技有限公司 Adult formula milk powder for reconstructing and strengthening human body immunity

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Application publication date: 20210507