CN112741892A - Traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, oral liquid and preparation method - Google Patents
Traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, oral liquid and preparation method Download PDFInfo
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Abstract
The invention relates to the technical field of veterinary medicines, and in particular relates to a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, an oral liquid and a preparation method. The raw materials of the traditional Chinese medicine composition contain cuttlebone, calcined corrugated, dried ginger, cinnamon, fructus amomi, nutmeg, fried hawthorn, honey-fried licorice root and fried bighead atractylodes rhizome, the traditional Chinese medicine composition is quick in effect taking, can quickly improve the feed intake of poultry, recovers the digestive function of the poultry, and is not easy to relapse after the poultry recovers.
Description
Technical Field
The invention relates to the technical field of veterinary medicines, and in particular relates to a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, an oral liquid and a preparation method.
Background
At present, the poultry breeding industry develops to large-scale breeding, and more large-scale breeding enterprises are provided, so that the problem of poultry diseases is brought while the breeding level is improved. The myoglandular gastritis is a common poultry disease, broiler chickens have diseases at the earliest age of 7 days, and the diseases are represented by reduced feed intake, slow growth, poor group uniformity and poor feed digestion, and the serious diseases can cause death of the poultry and bring great loss to the breeding industry.
The traditional Chinese veterinary medicine has the characteristics of green safety, no medicine residue, no damage to the functions of various internal organs of poultry and the like, and is more and more emphasized in the poultry breeding industry. Particularly, after the antibiotic is reduced and used in China, the application amount of the traditional Chinese veterinary medicine in the poultry breeding industry is increased day by day, and the application range is wider and wider.
At present, most of traditional Chinese veterinary medicines for treating poultry myoglandular gastritis are prepared from traditional Chinese medicines such as bighead atractylodes rhizome, poria cocos, medicated leaven, malt, bletilla striata and astragalus membranaceus, mainly have the conditioning effect of invigorating spleen and stimulating appetite, and possibly use the traditional Chinese medicines with the anti-inflammatory effect at the same time, but the traditional Chinese medicines have slow effect on the whole, cannot completely cure diseases, and have strong disease repeatability.
Disclosure of Invention
Aiming at the technical problems that the traditional Chinese veterinary medicine for treating poultry myoglandular gastritis in the prior art has slow drug effect and can not completely cure the diseases, the invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, an oral liquid and a preparation method thereof. The Chinese medicinal composition has quick response, can quickly improve the feed intake of poultry, recover the digestive function of the poultry, and is not easy to relapse after the poultry recovers.
In order to solve the technical problems, a first aspect of the embodiments of the present invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which comprises the following raw materials in parts by weight: 20-25 parts of cuttlebone, 15-20 parts of calcined flute, 15-20 parts of dried ginger, 10-15 parts of cinnamon, 15-20 parts of fructus amomi, 10-15 parts of nutmeg, 15-20 parts of fried hawthorn, 15-20 parts of honey-fried licorice root and 10-15 parts of fried bighead atractylodes rhizome.
The traditional Chinese medicine composition is prepared from medicines which are mainly used for warming middle-jiao to dispel cold, relieving hyperacidity and relieving pain and have the functions of tonifying spleen and promoting appetite in an auxiliary mode, can quickly improve the feed intake of poultry, can recover the digestive function of the poultry and can effectively prevent relapse.
The cuttlebone sheath is salty and astringent in taste and warm in nature, and has the effects of astringing to stop bleeding, arresting seminal emission, stopping leukorrhagia, relieving hyperacidity and pain, astringing dampness and healing sore;
the calcined corrugation is salty in taste and neutral in nature, has the effects of eliminating phlegm and reducing phlegm, softening and resolving masses, relieving hyperacidity and relieving pain, and has obvious antacid and analgesic effects on hyperacidity and gastric and duodenal ulcer;
the dried ginger is pungent in flavor and warm in nature, mainly enters the interior, and mainly enters the spleen and stomach of middle-jiao, warms the middle-jiao to dispel cold, returns yang to activate collaterals, warms the lung and dissolves fluid retention;
cinnamon is pungent and sweet in taste and large in nature and heat, and has the effects of tonifying fire, supporting yang, guiding fire to return to original, dispelling cold, relieving pain, warming and dredging channels and collaterals, and tonifying middle-jiao and Qi;
fructus Amomi is pungent in flavor, warm in nature, fragrant and dispersible, and has effects in promoting qi circulation, regulating middle warmer, regulating stomach function, activating spleen, relieving vomit, relieving diarrhea, regulating qi-flowing, and eliminating dampness;
nutmeg is pungent in flavor, warm in nature, and very mild in drug property, and can astringe intestines to stop diarrhea, warm middle-jiao and regulate spleen, promote qi circulation and stimulate appetite, promote digestion and descend qi, inhibit bacteria, and calm;
the fried hawthorn is sour and sweet in taste and slightly warm in nature, and has the effects of tonifying spleen, promoting appetite, promoting digestion, removing food stagnation, promoting blood circulation, reducing phlegm, soothing liver and relieving depression;
the honey-fried licorice root is sweet in taste and neutral in nature, has the effects of tonifying qi and nourishing yin, dispelling yang and recovering pulse, and can tonify spleen and stomach, relieve cough and asthma, reduce phlegm, clear heat and remove toxicity and relieve pain;
the fried bighead atractylodes rhizome is bitter in taste, sweet and warm in nature, and has the functions of tonifying spleen and qi, nourishing yin and tonifying kidney, nourishing and protecting stomach, promoting digestion, eliminating dampness and promoting diuresis and suppressing sweating.
The recipe adopts a treatment method of warming spleen and stomach for dispelling cold, strengthening spleen and stomach, warming spleen and stomach for promoting qi circulation, and relieving hyperacidity and pain. In the formula, the dried ginger and the cinnamon bark are monarch drugs for warming the middle-jiao to dispel cold, the sea cowherb sheath and the calcined flute are used for relieving acidity and pain, and the sore healing and bleeding stopping are used as monarch drugs; fructus Amomi and semen Myristicae, with pungent and warm properties, have effects of warming the middle-jiao and promoting qi circulation, and can be used as ministerial drugs for improving the effect of principal drugs in warming the middle-jiao and dispelling cold; the fried bighead atractylodes rhizome and the fried licorice root are used for tonifying spleen and replenishing qi, the fried hawthorn is used for strengthening spleen and stomach, promoting digestion and removing stasis as adjuvant drugs, and the licorice root is used for harmonizing the other drugs as guiding drugs.
The calcined flute is good at relieving hyperacidity and pain, healing sore and stopping bleeding, while the flute is good at dissipating stasis and eliminating phlegm, softening hardness and dissipating stagnation, and the calcined flute is adopted in the monarch drug of the formula, so that the composition can quickly take effect on the conditions of ulcer, inflammation and hyperacidity, effectively inhibit the aggravation of the disease, and is not easy to relapse after recovery.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 22-24 parts of cuttlebone, 16-19 parts of calcined flute, 16-19 parts of dried ginger, 11-13 parts of cinnamon, 16-19 parts of fructus amomi, 11-13 parts of nutmeg, 17-19 parts of fried hawthorn, 17-19 parts of honey-fried licorice root and 12-14 parts of fried bighead atractylodes rhizome.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 23 parts of cuttlebone, 17 parts of calcined flute, 17 parts of dried ginger, 12 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
In a second aspect, the embodiment of the present invention further provides a preparation method of the above traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which specifically includes the following steps:
s1, weighing the raw materials in parts by weight; decocting the cuttlebone and calcined concha arcae with water, filtering to obtain decoction, and concentrating the obtained decoction to obtain concentrated solution;
s2, extracting volatile oil from the dried ginger by a steam distillation method to obtain the dried ginger volatile oil, a distilled water solution and ginger residue;
s3, washing the cinnamon, the fructus amomi, the nutmeg, the fried hawthorn, the honey-fried licorice root, the fried bighead atractylodes rhizome and the ginger slag with water, then decocting the materials with water for 110-130 min, filtering decoction liquid, decocting the medicine slag with water for 1.4-1.6 h, filtering decoction liquid, merging the obtained decoction liquids, concentrating the decoction liquids until the relative density of the decoction liquids is 1.15-1.20 at 70-80 ℃, carrying out alcohol precipitation under the condition that the alcohol concentration is 70-80% (v/v), filtering, removing ethanol from the obtained filtrate, adjusting the pH of the obtained filtrate to 5.4-5.6 with lactic acid, refrigerating for 20-28 h, filtering, and obtaining refrigerated filtrate; the relative density at 70-80 ℃ is 1.15-1.20, i.e., the ratio of the density at 70-80 ℃ to the density of pure water at the same temperature is 1.15-1.20.
S4, mixing the concentrated solution obtained in S1, the volatile oil and distilled water solution of dried ginger obtained in S2 and the cold-stored filtrate obtained in S3.
After the traditional Chinese medicine composition is extracted and processed by the preparation method, the obtained product is directly administrated by stomach irrigation or added into daily drinking water for poultry to take, and the effect of preventing and treating the poultry myoglandular gastritis is superior to the effect of directly crushing and then administrating the traditional Chinese medicine composition and the effect of water decoction obtained by a conventional water decoction method.
The decoction obtained in S1 is preferably extracted by decocting for 2 times, each time for 1 hr. The decoction can be centrifuged once again before concentration to further remove residue and reduce solid residue in the decoction. Concentrating the decoction until the relative density of the decoction is 1.0-1.1 at 70-80 ℃.
Optionally, the alcohol decoction of S3 may be centrifuged once before concentration to further remove residue.
The operation of alcohol precipitation in S3 is preferably: standing for 12 hours after the alcohol concentration reaches 70-80% (v/v), filtering to obtain a filtrate, adding ethanol into the residue until the alcohol concentration reaches 70-80% (v/v), and standing for 12 hours. Precipitating with ethanol, filtering, and mixing filtrates. The method for removing ethanol from the filtrate can be vacuum concentration, and recovering ethanol.
In a third aspect, the embodiment of the invention also provides an oral liquid for preventing and treating poultry myoglandular gastritis, which contains the traditional Chinese medicine composition prepared by the preparation method of the traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis.
Preferably, the oral liquid for preventing and treating poultry myoglandular gastritis further contains a surfactant and a preservative.
Preferably, the surfactant is tween 80, the preservative is potassium sorbate and methylparaben, the tween 80 is preferably contained in an amount of 0.4 wt.% to 0.6 wt.%, the potassium sorbate is preferably contained in an amount of 0.2 wt.% to 0.3 wt.%, and the methylparaben is preferably contained in an amount of 0.08 wt.% to 0.12 wt.%.
Preferably, the preparation method of the oral liquid for preventing and treating poultry myoglandular gastritis comprises the following steps:
dissolving the Tween 80 and the potassium sorbate in hot water, adding the dissolved methyl p-hydroxybenzoate into the Chinese medicinal composition prepared by the preparation method, mixing uniformly, adding the dissolved methyl p-hydroxybenzoate, and mixing uniformly.
The obtained oral liquid can be directly used for gastric lavage administration, or added into drinking water for poultry, or diluted with water to desired concentration, filtered, and filled to control administration concentration or commercialize.
Wherein the hot water and ethanol can dissolve Tween 80, potassium sorbate and methyl p-hydroxybenzoate, so as to avoid reducing concentration of Chinese medicinal composition in the product due to excessive consumption.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which comprises the following raw materials: 23 parts of cuttlebone, 17 parts of calcined flute, 17 parts of dried ginger, 12 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, weighing the raw materials in parts by weight; loosely packaging cuttlebone and calcined flute with a non-woven filter bag, adding 8 times of water for decoction and extraction for 2 times, each time for 1h, filtering to obtain decoction, combining the obtained decoction, centrifuging, and concentrating the supernatant until the relative density of the supernatant is 1.0-1.1 at 70-80 ℃ to obtain a concentrated solution;
s2, extracting volatile oil from rhizoma Zingiberis by steam distillation to obtain volatile oil, distilled water solution and residue;
s3, adding cinnamon, fructus amomi, nutmeg, fried hawthorn, honey-fried licorice root, fried bighead atractylodes rhizome and ginger slag into an extraction tank, adding water for cleaning once, then decocting for 2 hours by using 8 times of water, filtering to obtain decoction, decocting the dregs for 1.5 hours by using 8 times of water, filtering to obtain decoction, merging the obtained decoction, centrifuging, concentrating the supernatant until the relative density at 75 ℃ is 1.15, adding ethanol until the ethanol concentration reaches 75% (v/v), standing for 12 hours, filtering to obtain filtrate, adding ethanol into the residue until the ethanol concentration reaches 75% (v/v), standing for 12 hours, filtering to obtain filtrate, merging the obtained filtrate, concentrating under reduced pressure to recover the ethanol, adjusting the pH to 5.5 by using lactic acid, refrigerating for 24 hours, filtering to obtain filtrate after refrigerating;
s4, mixing the concentrated solution obtained in S1, the volatile oil of dried ginger obtained in S2 and the filtrate obtained in S3 after refrigeration.
Example 2
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which comprises the following raw materials: 22 parts of cuttlebone, 16 parts of calcined flute, 16 parts of dried ginger, 11 parts of cinnamon, 16 parts of fructus amomi, 11 parts of nutmeg, 17 parts of fried hawthorn, 17 parts of honey-fried licorice root and 12 parts of fried bighead atractylodes rhizome.
The preparation method of the traditional Chinese medicine composition is the same as that of example 1.
Example 3
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which comprises the following raw materials: 24 parts of cuttlebone, 19 parts of calcined flute, 19 parts of dried ginger, 13 parts of cinnamon, 19 parts of fructus amomi, 13 parts of nutmeg, 19 parts of fried hawthorn, 19 parts of honey-fried licorice root and 14 parts of fried bighead atractylodes rhizome.
The preparation method of the traditional Chinese medicine composition is the same as that of example 1.
Example 4
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which comprises the following raw materials: 20 parts of cuttlebone, 15 parts of calcined flute, 15 parts of dried ginger, 10 parts of cinnamon, 15 parts of fructus amomi, 10 parts of nutmeg, 15 parts of fried hawthorn, 15 parts of honey-fried licorice root and 10 parts of fried bighead atractylodes rhizome.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, weighing the raw materials in parts by weight; loosely packaging cuttlebone and calcined flute with a non-woven filter bag, adding 8 times of water for decoction and extraction for 2 times, each time for 1h, filtering to obtain decoction, combining the obtained decoction, centrifuging, and concentrating the supernatant until the relative density of the supernatant is 1.0-1.1 at 70-80 ℃ to obtain a concentrated solution;
s2, extracting volatile oil from rhizoma Zingiberis by steam distillation to obtain volatile oil, distilled water solution and residue;
s3, adding cinnamon, fructus amomi, nutmeg, fried hawthorn, honey-fried licorice root, fried bighead atractylodes rhizome and ginger slag into an extraction tank, adding water for cleaning once, then decocting for 110min by using 8 times of water, filtering to obtain decoction, decocting the dregs for 1.4h by using 8 times of water, filtering to obtain decoction, merging the obtained decoction, centrifuging, concentrating the supernatant until the relative density at 80 ℃ is 1.15, adding ethanol until the ethanol concentration reaches 70% (v/v), standing for 12 h, filtering to obtain filtrate, adding ethanol into the residue until the ethanol concentration reaches 70% (v/v), standing for 12 h, filtering to obtain filtrate, merging the obtained filtrate, concentrating under reduced pressure to recover the ethanol, adjusting the pH to 5.4 by using lactic acid, refrigerating for 24h, filtering to obtain filtrate after refrigerating;
s4, mixing the concentrated solution obtained in S1, the volatile oil of dried ginger obtained in S2 and the filtrate obtained in S3 after refrigeration.
Example 5
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, which comprises the following raw materials: 25 parts of cuttlebone, 20 parts of calcined flute, 20 parts of dried ginger, 15 parts of cinnamon, 20 parts of fructus amomi, 15 parts of nutmeg, 20 parts of fried hawthorn, 20 parts of honey-fried licorice root and 15 parts of fried bighead atractylodes rhizome.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, weighing the raw materials in parts by weight; loosely packaging cuttlebone and calcined flute with a non-woven filter bag, adding 8 times of water for decoction and extraction for 2 times, each time for 1h, filtering to obtain decoction, combining the obtained decoction, centrifuging, and concentrating the supernatant until the relative density of the supernatant is 1.0-1.1 at 70-80 ℃ to obtain a concentrated solution;
s2, extracting volatile oil from rhizoma Zingiberis by steam distillation to obtain volatile oil, distilled water solution and residue;
s3, adding cinnamon, fructus amomi, nutmeg, fried hawthorn, honey-fried licorice root, fried bighead atractylodes rhizome and ginger slag into an extraction tank, adding water for cleaning once, then decocting for 130min by using 8 times of water, filtering to obtain decoction, decocting the dregs for 1.6h by using 8 times of water, filtering to obtain decoction, merging the obtained decoction, centrifuging, concentrating the supernatant until the relative density at 70 ℃ is 1.20, adding ethanol until the ethanol concentration reaches 80% (v/v), standing for 12 h, filtering to obtain filtrate, adding ethanol into the residue until the ethanol concentration reaches 80% (v/v), standing for 12 h, filtering to obtain filtrate, merging the obtained filtrate, concentrating under reduced pressure to recover ethanol, adjusting the pH value to 5.6 by using lactic acid, refrigerating for 24h, filtering to obtain filtrate after refrigerating;
s4, mixing the concentrated solution obtained in S1, the volatile oil of dried ginger obtained in S2 and the filtrate obtained in S3 after refrigeration.
Example 6
The embodiment of the invention provides an oral liquid for preventing and treating poultry myoglandular gastritis, which comprises the traditional Chinese medicine composition prepared in the embodiment 1, tween 80, potassium sorbate and methylparaben, wherein the content of the tween 80 is 0.5 wt.%, the content of the potassium sorbate is 0.25 wt.%, and the content of the methylparaben is 0.1 wt.%.
The preparation method of the oral liquid comprises the following steps:
dissolving Tween 80 and potassium sorbate with small amount of hot water under stirring, adding into the Chinese medicinal composition prepared in example 1, mixing, adding methyl p-hydroxybenzoate dissolved in ethanol, and mixing;
adding purified water to make the concentration of the Chinese medicinal composition in the product reach the desired concentration, stirring for 20 min, filtering, and packaging.
Comparative example 1
The comparative example provides a traditional Chinese medicine composition, which is prepared by replacing a forged corrugated container with a corrugated container on the basis of example 1. The preparation method specifically comprises the following raw materials: 23 parts of cuttlebone, 17 parts of corrugated paper, 17 parts of dried ginger, 12 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
The preparation method is the same as example 1.
Comparative example 2
The comparative example provides a traditional Chinese medicine composition, which is prepared by replacing dried ginger with ginger based on example 1. The preparation method specifically comprises the following raw materials: 23 parts of cuttlebone, 17 parts of calcined flute, 17 parts of ginger, 12 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
The preparation method is the same as example 1.
Comparative example 3
The comparative example provides a traditional Chinese medicine composition, which is prepared by removing cuttlebone and increasing the consumption of calcined concha arcae based on example 1. The preparation method specifically comprises the following raw materials: 40 parts of calcined corrugated paper, 17 parts of dried ginger, 12 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
The preparation method is the same as example 1.
Comparative example 4
The comparative example provides a traditional Chinese medicine composition, which is prepared by removing dried ginger and increasing the amount of cinnamon based on example 1. The preparation method specifically comprises the following raw materials: 23 parts of cuttlebone, 17 parts of calcined corrugated paper, 29 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
The preparation method is the same as example 1.
Comparative example 5
The comparative example provides a traditional Chinese medicine composition, the raw materials of which are the same as those in example 1, and the preparation method comprises the following steps:
weighing the raw materials according to the weight part ratio, adding 8 times of water for decocting and extracting for 2 times, each time for 1 hour, filtering and taking decoction, combining the obtained decoction, centrifuging, and concentrating supernate until the relative density of 70-80 ℃ is 1.15-1.20.
Effect example 1
520 Aijia Yijia broilers with the age of 14 days are selected and randomly divided into 13 groups, and each group comprises 40, namely, a group of examples 1-5, a group of comparative examples 1-5, a blank control group, a negative control group and a positive control group. The blank control group uses normal feed, and other groups add endotoxin (20mg/kg. bw) and aflatoxin B1(40 mu g/kg feed) into the feed for 5 days, so that the broiler chickens suffer from spleen-stomach deficiency-cold type myoglandular gastritis. Meanwhile, the traditional Chinese medicine compositions obtained in the groups 1-5 and the groups 1-5 are respectively added into drinking water in the groups 1-5 and the groups 1-5, the addition amount is 0.5ml/kg of water, and the drinking water is used for 7 days; the positive control group is administrated with amoxicillin and cimetidine by intragastric administration, the dosage of amoxicillin is 20mg/kg body weight, the dosage of cimetidine is 5mg/kg body weight, and the administration lasts for 7 days.
Weighing before and 7 days after administration, collecting pathological materials, and performing laboratory detection. Measurement indexes are as follows: (1) the production performance index is as follows: average daily food intake and feed-meat ratio. (2) The curative effect index is as follows: effective rate, cure rate, mortality, glandular stomach index, myogastric index, glandular stomach and myogastric pH.
The production performance index is shown in Table 1.
Table 1 index of production Performance
| Group of | Average daily food intake (g) | Average body weight (g) | Meat ratio of materials |
| Blank control group | 70.13±0.21 | 788.15±0.72 | 1.64±0.007 |
| Negative control group | 52.13±0.09a | 690.77±0.72a | 1.79±0.007a |
| Positive control group | 60.13±0.11ab | 735.35±0.62ab | 1.68±0.005b |
| EXAMPLE 1 group | 69.23±0.21bc | 790.34±0.84bc | 1.65±0.007b |
| EXAMPLE 2 group | 69.10±0.18bc | 786.43±0.56bc | 1.65±0.006b |
| EXAMPLE 3 group | 69.17±0.19bc | 788.23±0.81bc | 1.66±0.007b |
| EXAMPLE 4 group | 68.59±0.17bc | 782.41±0.63bc | 1.67±0.005b |
| EXAMPLE 5 group | 68.71±0.15bc | 784.59±0.42bc | 1.67±0.007b |
| Comparative example 1 group | 65.29±0.20abcd | 741.26±0.51abd | 1.69±0.006b |
| Comparative example 2 group | 64.71±0.14abcd | 753.17±0.68abcd | 1.68±0.007b |
| Comparative example 3 group | 62.10±0.18abd | 738.19±0.75abd | 1.69±0.005b |
| Comparative example 4 group | 63.87±0.16abcd | 745.21±0.64abcd | 1.69±0.007b |
| Comparative example 5 group | 61.58±0.15abd | 728.57±0.69abd | 1.68±0.006b |
Note: a, comparing each group with a blank group, wherein P is less than 0.05; b, comparing the positive control group, the groups of the examples and the comparative examples with the negative control group, wherein P is less than 0.05; c, comparing each group of the examples and each group of the comparative examples with the positive control group, P is less than 0.05; comparative examples the groups compared to example 1, P < 0.05.
According to statistics of production performance data 7 days after administration, the influence of average daily food consumption and average body weight on the groups of examples 1-5 is not significant (P is more than 0.05) compared with a blank control group, and is significant (P is less than 0.05) compared with a negative control group and a positive control group; the influence of the groups of examples 1-5 on the feed-meat ratio is not significant (P >0.05) compared with the blank control group and the positive control group, and is significant (P <0.05) compared with the negative control group. Comparative examples groups were significantly different between average daily food intake, average body weight and example 1 (P > 0.05). The results show that the traditional Chinese medicine composition obtained in the examples 1-5 has good prevention and treatment effects on the broiler proventriculitis, and the example 1 is superior to each group of comparative examples in terms of average daily food consumption and average body weight.
The therapeutic index is shown in tables 2-4.
Table 2 effective rate, cure rate and mortality rate of each group
| Group of | Effective rate (%) | Cure rate (%) | Mortality (%) |
| Blank control group | 100％ | 100％ | 0 |
| Negative control group | 0 | 0 | 65 |
| Positive control group | 85 | 80 | 12.5 |
| EXAMPLE 1 group | 92.5 | 87.5 | 2.5 |
| EXAMPLE 2 group | 90.0 | 85.0 | 2.5 |
| EXAMPLE 3 group | 90.0 | 87.5 | 2.5 |
| EXAMPLE 4 group | 87.5 | 85.0 | 5.0 |
| EXAMPLE 5 group | 85.0 | 82.5 | 5.0 |
| Comparative example 1 group | 75.0 | 72.5 | 10.0 |
| Comparative example 2 group | 77.5 | 75.0 | 7.5 |
| Comparative example 3 group | 75.0 | 67.5 | 10.0 |
| Comparative example 4 group | 77.5 | 75.0 | 10.0 |
| Comparative example 5 group | 72.5 | 67.5 | 7.5 |
Statistics on the effective rate, the cure rate and the death rate of the broiler chickens after 7 days of administration show that the broiler chickens in the blank control group are healthy, the cure rate of 85-92.5% in the groups in examples 1-5 is higher than that of 85% in the positive control group, the death rate of 65% in the negative control group, the effective rate and the cure rate of each group in the examples are higher than those in the comparative examples, and the death rate of each group in the examples is lower than that in the comparative examples. Experiments prove that the traditional Chinese medicine composition obtained in the groups 1-5 has good effect on treating the myoglandular gastritis.
TABLE 3 glandular gastric index and myogastric index for each group: (
In weight percent to the living body)
| Group of | Index of glandular stomach | Muscular stomach index |
| Blank control group | 0.67±0.18 | 2.93±0.09 |
| Negative control group | 0.54±0.14a | 2.65±0.18a |
| Positive control group | 0.61±0.13ab | 2.87±0.12ab |
| EXAMPLE 1 group | 0.66±0.08bc | 2.91±0.07b |
| EXAMPLE 2 group | 0.65±0.11bc | 2.89±0.13b |
| EXAMPLE 3 group | 0.65±0.09bc | 2.90±0.09b |
| EXAMPLE 4 group | 0.63±0.13bc | 2.88±0.12b |
| EXAMPLE 5 group | 0.64±0.16bc | 2.88±0.10b |
| Comparative example 1 group | 0.60±0.12abd | 2.86±0.11ab |
| Comparative example 2 group | 0.62±0.14abd | 2.85±0.15ab |
| Comparative example 3 group | 0.61±0.15abd | 2.87±0.12ab |
| Comparative example 4 group | 0.62±0.10abd | 2.86±0.14ab |
| Comparative example 5 group | 0.59±0.11abd | 2.85±0.11ab |
Note: a, comparing each group with a blank group, wherein P is less than 0.05; b, comparing the positive control group, the groups of the examples and the comparative examples with the negative control group, wherein P is less than 0.05; c, comparing each group of the examples and each group of the comparative examples with the positive control group, P is less than 0.05; comparative examples the groups compared to example 1, P < 0.05.
Statistics of the glandular stomach index and the muscular stomach index 7 days after administration of the medicine show that compared with a negative control group, the glandular stomach index and the muscular stomach index (P is less than 0.05) of the groups of examples 1-5 can be remarkably improved, and the difference between the glandular stomach index and the positive control group (P is less than 0.05). The results prove that the traditional Chinese medicine composition obtained in the examples 1-5 can improve the digestion capacity of broiler chickens. Also, the glandular stomach index and the myogastric index of the group of example 1 were superior to those of the groups of comparative examples.
TABLE 4 glandular gastric pH and myogastric pH for each group
Note: a, comparing each group with a blank group, wherein P is less than 0.05; b, comparing the positive control group, the groups of the examples and the comparative examples with the negative control group, wherein P is less than 0.05; c comparing each group of examples and each group of comparative examples with the positive control group, P is less than 0.05.
Statistics of the glandular stomach index and the muscular stomach index after 7 days of administration shows that the pH values of the glandular stomach and the muscular stomach in the groups of examples 1-5 are significantly higher than those of the negative control group, and the difference is significant (P is less than 0.05), so that the traditional Chinese medicine composition obtained in the groups of examples 1-5 has the function of inhibiting gastric acid secretion, can reduce stimulation of gastric acid on gastric ulcer, reduces pain, and is beneficial to treatment of the myoglandular gastritis. Also, the glandular and muscular stomach pH was higher in the example 1 group than in the comparative example groups.
And (5) observing the cured recovered broiler chickens to get out of the cages, and counting the recurrence condition of the myoglandular gastritis of the recovered broiler chickens. The results are shown in Table 5.
TABLE 5 relapse status in each group
| Group of | Recurrence Rate (%) |
| EXAMPLE 1 group | 0 |
| EXAMPLE 2 group | 0 |
| EXAMPLE 3 group | 0 |
| EXAMPLE 4 group | 0 |
| EXAMPLE 5 group | 0 |
| Comparative example 1 group | 3.4 |
| Comparative example 2 group | 3.3 |
| Comparative example 3 group | 7.4 |
| Comparative example 4 group | 6.7 |
| Comparative example 5 group | 7.4 |
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis is characterized by comprising the following raw materials in parts by weight: 20-25 parts of cuttlebone, 15-20 parts of calcined flute, 15-20 parts of dried ginger, 10-15 parts of cinnamon, 15-20 parts of fructus amomi, 10-15 parts of nutmeg, 15-20 parts of fried hawthorn, 15-20 parts of honey-fried licorice root and 10-15 parts of fried bighead atractylodes rhizome.
2. The traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 22-24 parts of cuttlebone, 16-19 parts of calcined flute, 16-19 parts of dried ginger, 11-13 parts of cinnamon, 16-19 parts of fructus amomi, 11-13 parts of nutmeg, 17-19 parts of fried hawthorn, 17-19 parts of honey-fried licorice root and 12-14 parts of fried bighead atractylodes rhizome.
3. The traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis according to claim 2 is characterized by comprising the following raw materials in parts by weight: 23 parts of cuttlebone, 17 parts of calcined flute, 17 parts of dried ginger, 12 parts of cinnamon, 18 parts of fructus amomi, 12 parts of nutmeg, 18 parts of fried hawthorn, 18 parts of honey-fried licorice root and 13 parts of fried bighead atractylodes rhizome.
4. The preparation method of the traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis as claimed in any one of claims 1 to 3, which is characterized by comprising the following steps:
s1, weighing the raw materials in parts by weight; decocting the cuttlebone and calcined concha arcae with water, filtering to obtain decoction, and concentrating the obtained decoction to obtain concentrated solution;
s2, extracting volatile oil from the dried ginger by a steam distillation method to obtain the dried ginger volatile oil, a distilled water solution and ginger residue;
s3, washing the cinnamon, the fructus amomi, the nutmeg, the fried hawthorn, the honey-fried licorice root, the fried bighead atractylodes rhizome and the ginger slag with water, then decocting the materials with water for 110-130 min, filtering decoction liquid, decocting the medicine slag with water for 1.4-1.6 h, filtering decoction liquid, merging the obtained decoction liquids, concentrating the decoction liquids until the relative density of the decoction liquids is 1.15-1.20 at 70-80 ℃, carrying out alcohol precipitation under the condition that the alcohol concentration is 70-80% (v/v), filtering, removing ethanol from the obtained filtrate, adjusting the pH of the obtained filtrate to 5.4-5.6 with lactic acid, refrigerating for 20-28 h, filtering, and obtaining refrigerated filtrate;
s4, mixing the concentrated solution obtained in S1, the volatile oil and distilled water solution of dried ginger obtained in S2 and the cold-stored filtrate obtained in S3.
5. The preparation method of the traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis as claimed in claim 4, wherein the water obtained in S1 is decocted for 2 times, 1h each time.
6. The preparation method of the traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis as claimed in claim 4, wherein the operation of alcohol precipitation in S3 is as follows: standing for 12 hours after the alcohol concentration reaches 70-80% (v/v), filtering to obtain a filtrate, adding ethanol into the residue until the alcohol concentration reaches 70-80% (v/v), and standing for 12 hours.
7. An oral liquid for preventing and treating poultry myoglandular gastritis, which is characterized by comprising the traditional Chinese medicine composition prepared by the preparation method of the traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis according to any one of claims 4 to 6.
8. The oral liquid for preventing and treating poultry myoglandular gastritis as claimed in claim 7, wherein the oral liquid further comprises a surfactant and a preservative.
9. The oral liquid for preventing and treating poultry myoglandular gastritis as claimed in claim 8, wherein the surfactant is Tween 80, and the preservative is potassium sorbate and methylparaben.
10. The oral liquid for preventing and treating poultry myoglandular gastritis as claimed in claim 9, wherein the preparation method of the oral liquid for preventing and treating poultry myoglandular gastritis is as follows:
dissolving the Tween 80 and the potassium sorbate in hot water, adding the mixture into the traditional Chinese medicine composition prepared by the preparation method of any one of claims 4 to 6, uniformly mixing, adding the methyl p-hydroxybenzoate dissolved in ethanol, and uniformly mixing.
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