CN112704518B

CN112704518B - Sampling tube and sampling assembly

Info

Publication number: CN112704518B
Application number: CN202011278044.2A
Authority: CN
Inventors: 顾大勇; 樊冰; 刘秀卿; 余叠传; 阎清茹; 张海燕
Original assignee: Shenzhen Second Peoples Hospital
Current assignee: Shenzhen Maijia Biomedical Co ltd
Priority date: 2020-11-16
Filing date: 2020-11-16
Publication date: 2023-10-31
Anticipated expiration: 2040-11-16
Also published as: CN112704518A

Abstract

The present application relates to a sampling tube and sampling assembly. The sampling tube comprises a tube body and a fixing piece, wherein the tube body is provided with a tube wall part and a bottom part in sealing connection with the tube wall part, the fixing piece is positioned in the tube body and is close to the bottom part, the fixing piece, the tube wall part and the bottom part together form a containing cavity for containing the swab, and when the swab is contained in the containing cavity, the axial included angle between the swab and the tube body is not more than 30 degrees. When in use, the sampling tube is convenient for sucking the liquid in the sampling tube.

Description

Sampling tube and sampling assembly

Technical Field

The application relates to the field of medical instruments, in particular to a sampling tube and a sampling assembly.

Background

The traditional clinical sampler comprises a sampling swab and a sampling tube, wherein the sampling tube is mostly adoptedA plastic or glass tube of (10-16) x (6-10) mm will typically contain 1-10 mL of preservation or lysis solution to maintain the activity of the sample collected by the sampling swab or to simply pretreat the sample. When the sampling device is used, the sampling head of the sampling swab is used for sampling at the corresponding position, then the sampling head with the sample is placed into the sampling tube, and the sampling swab is broken off, so that the sampling head with the sample falls into the preservation solution or the lysis solution in the sampling tube, and then the tube cover of the sampling tube is screwed for standby detection. In the detection, the preservation solution or the lysate soaked in the sampling head with the sample needs to be sucked out.

However, in the sampling tube of the conventional sampler, the broken sampling swab easily hinders the sucking of the preserving fluid or the lysis fluid in the sampling tube, and the phenomenon of incapability of sucking or insufficient sucking is easily caused. In view of the above, the main current handling is to clip the broken swab out and then to re-wick it, but this increases the risk of sample contamination and infection of the user.

Disclosure of Invention

Accordingly, there is a need for a sampling tube that is less likely to fail to or be deficient in sample collection, that is less likely to contaminate a sample when used, and that is highly safe to use.

A sampling tube comprising:

the pipe body is provided with a pipe wall part and a bottom part which is connected with the pipe wall part in a sealing way; a kind of electronic device with high-pressure air-conditioning system

The fixing piece is positioned in the pipe body and is close to the bottom of the pipe body, the fixing piece, the pipe wall portion of the pipe body and the bottom of the pipe body form an accommodating cavity for accommodating the swab, and when the swab is accommodated in the accommodating cavity, an included angle between the axial direction of the swab and the axial direction of the pipe body is not more than 30 degrees.

According to the sampling tube, the fixing piece is arranged in the tube body, so that the fixing piece, the tube wall part and the bottom of the tube body form the accommodating cavity for accommodating the swab, and when the sampling tube is used, the accommodating cavity can accommodate the swab, and the included angle between the axial direction of the swab and the axial direction of the tube body is not more than 30 degrees, so that enough space is reserved in the tube body for sucking liquid in the tube body, the liquid is not easy to be blocked by the swab during liquid suction, and the condition that sampling cannot be performed or sampling is insufficient is not easy to occur; at the same time, the risk of contamination of the sample and infection of the user is reduced, since no clamping of the swab is required.

In one embodiment, the swab is axially aligned with the tube when the swab is received in the receiving chamber.

In one embodiment, the fixing member is disposed on the bottom, and one side of the fixing member is spaced from the tube wall, and the accommodating cavity can accommodate the sampling head of the swab and cooperate with the inner side of the tube wall to clamp the sampling head.

In one embodiment, the tube body is provided with a tube opening, the fixing piece is provided with a first surface, the first surface faces the tube opening, and an included angle between the first surface and the axial direction of the tube body is 45-90 degrees.

In one embodiment, the fixing member has a second surface, the second surface is adjacent to the first surface, the second surface is spaced from the pipe wall, and an included angle between the second surface and an axial direction perpendicular to the pipe body is 0 ° to 90 °.

In one embodiment, the ratio of the maximum length of the fixing member in the axial direction of the pipe body to the length of the pipe body is 1: (3-4).

In one embodiment, the inner diameter of the pipe body is 13 mm-16 mm, and the maximum length of the fixing piece in the axial direction perpendicular to the pipe body is 8 mm-11 mm.

In one embodiment, the sampling tube further comprises a cap for covering the mouth of the tube to seal the tube.

In one embodiment, the cover body is provided with a sampling mark part, and when the pipe body is in a sealed state, the orthographic projection of the sampling mark part on the bottom is not overlapped with the orthographic projection of the accommodating cavity on the bottom.

A sampling assembly comprises the sampling tube and the swab, wherein when the swab is accommodated in the accommodating cavity of the sampling tube, an included angle between the axial direction of the swab and the axial direction of the tube body of the sampling tube is not more than 30 degrees.

In one embodiment, the swab comprises a sampling handle having a crease therein which is adjacent to the nozzle of the sampling tube after insertion of the swab into the receiving chamber.

Drawings

One or more embodiments are illustrated by way of example and not limitation in the figures of the accompanying drawings, which are not to be construed as limiting the embodiments unless specifically indicated otherwise.

FIG. 1 is a schematic diagram of a sampling assembly prior to centrifugation according to an embodiment;

FIG. 2 is a schematic view of the sampling assembly shown in FIG. 1 after centrifugation;

FIG. 3 is a schematic diagram of a sampling assembly according to another embodiment;

FIG. 4 is a schematic illustration of a broken swab of the sampling assembly shown in FIG. 3;

fig. 5 is a schematic diagram of a sampling assembly of another embodiment.

Reference numerals:

10. a sampling assembly; 110. a swab; 130. a sampling tube; 111. a sampling head; 113. a sampling handle; 131. a tube body; 133. a fixing member; 131a, a tube wall portion; 131b, bottom; 135. a receiving chamber; 133a, a first face; 133b, a second face; 150. a cover body; 151. a sampling mark section; 114. crease lines.

20. A sampling assembly; 210. a swab; 233. a fixing member; 231a and a tube wall portion; 231b, bottom; 235. a receiving chamber.

Detailed Description

The present application will be described more fully hereinafter in order to facilitate an understanding of the application, which may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "fixed" to another element, it can be directly on the other element or one or more intervening elements may be present therebetween. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or one or more intervening elements may be present therebetween. When the terms "vertical," "horizontal," "left," "right," "upper," "lower," "inner," "outer," "bottom," and the like are used to indicate an orientation or a positional relationship, they are based on the orientation or positional relationship shown in the drawings, for convenience of description only, and do not indicate or imply that the apparatus or element in question must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the application. Furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

Referring to fig. 1 and 2, one embodiment of the present application provides a sampling assembly 10, the sampling assembly 10 comprising a swab 110 and a sampling tube 130.

Specifically, the swab 110 is used for sampling. The swab 110 is substantially rod-shaped. The swab 110 includes a sampling head 111 and a sampling handle 113 coupled to the sampling head 111. The sampling head 111 is a portion that directly contacts a sampling site at the time of sampling. In an alternative specific example, the sampling head 111 is spherical or ellipsoidal. It is understood that the shape of the sampling head 111 is not limited to a sphere or an ellipsoid, and may be other shapes. The sampling handle 113 has a hand-held portion thereon that is remote from the sampling head 111. In use, the hand held portion is held for sampling. In the present embodiment, the sampling handle 113 further has a fold 114, the fold 114 is adjacent to the sampling head 111, and after the swab 110 is folded by the fold 114, the portion with the sampling head 111 can be completely accommodated in the tube 131. The provision of the crease 114 makes it easier for the swab 110 to break and also reduces the risk of contamination of the sample, since the handle of the swab 110 does not fall into the tube 131.

Specifically, sampling tube 130 includes a tube body 131 and a fixture 133 located within tube body 131. The tube body 131 comprises a tube wall 131a and a bottom 131b, wherein the tube wall 131a and the bottom 131b are connected in a sealing way to form a cavity capable of containing liquid (such as preservation liquid or pyrolysis liquid); of course, the body 131 has a nozzle that is remote from the bottom 131b. In the present embodiment, the pipe wall 131a has a hollow cylindrical shape, and the bottom 131b has a constant curvature. In the embodiment shown in fig. 1, the bottom 131b projects away from the nozzle. Of course, in other embodiments, the tube wall 131a is not limited to a hollow cylinder, but may be other hollow structures, such as a hollow cuboid. The bottom 131b may also be arcless, i.e., flat bottom.

Specifically, the fixing member 133 is located in the cavity formed by the tube wall 131a and the bottom 131b and is close to the bottom 131b, and the fixing member 133 forms a receiving cavity 135 for receiving the swab 110 together with the tube wall 131a and the bottom 131b. When the swab 110 is accommodated in the accommodating cavity 135, the axial direction of the swab 110 and the axial direction of the tube 131 form an angle of not more than 30 degrees. For example, 2 °, 5 °, 8 °, 10 °, 12 °, 15 °, 18 °, 20 °, 25 °, 28 °, or the like. When the swab 110 is accommodated in the accommodating cavity 135, when the included angle between the axial direction of the swab 110 and the axial direction of the tube 131 is not more than 30 degrees, enough operation space can be reserved for sucking the liquid in the sampling tube 130, so that the liquid in the sampling tube 130 can be sucked conveniently. The axial direction of the tube 131 herein refers to a direction that is the same as the central axis of the tube 131; the axial direction of the swab 110 herein refers to a direction that is co-directional with the central axis of the swab 110. In fig. 1, the axial direction of the tube 131 is in the vertical direction, and the axial direction of the swab 110 is the same direction as the length direction of the swab 110.

Further, when the swab 110 is accommodated in the accommodating chamber 135, the axial direction of the swab 110 and the axial direction of the tube 131 form an angle of 0 ° to 10 °. Further, when the swab 110 is accommodated in the accommodating cavity 135, the axial direction of the swab 110 and the axial direction of the tube 131 form an angle of 0 ° to 6 °. In the illustrated embodiment, the axial direction of the swab 110 is the same as the axial direction of the tube 131 when the swab 110 is received in the receiving chamber 135. That is, when the swab 110 is accommodated in the accommodation chamber 135, the axial direction of the swab 110 forms an angle of 0 ° with the axial direction of the tube 131.

In some embodiments, the fixing member 133 is disposed on the bottom 131b and a portion of the side surface of the fixing member 133 is spaced apart from the pipe wall 131 a. In the illustrated embodiment, the fixing member 133 is disposed on the bottom 131b and one side of the fixing member 133 is spaced apart from the pipe wall 131a to form the receiving chamber 135 with the pipe wall 131a and the bottom 131b. Further, the fixing member 133 is fixed to the surface of the bottom portion 131b with one side of the fixing member 133 spaced apart from the pipe wall portion 131 a.

In some embodiments, receiving cavity 135 is capable of fully receiving sampling head 111 within receiving cavity 135. Alternatively, where the shape of the receiving cavity 135 is substantially the same as the shape of the sampling head 111, the volume of the receiving cavity 135 is equal to or slightly greater than the volume of the sampling head 111 (e.g., the ratio of the volume of the sampling head 111 to the volume of the receiving cavity 135 is 1:1.05-1.1). This arrangement allows the sampling head 111 to enter the receiving chamber 135 without excessive liquid in the receiving chamber 135, which can make the sampling inconvenient. Of course, in other embodiments, the receiving cavity 135 may be capable of partially receiving the sampling head 111, so long as the axial direction of the swab 110 and the axial direction of the tube 131 do not form an angle of more than 30 ° when the swab 110 is in the receiving cavity 135, so as to reserve more space for sucking the liquid in the sampling tube 130.

Further, the accommodation chamber 135 is also capable of holding the sampling head 111 in the accommodation chamber 135. By holding sampling head 111 in holding chamber 135, sampling head 111 is prevented from sliding out of holding chamber 135 and tilting out of holding chamber 135, preventing aspiration of liquid in sampling tube 130. Of course, in embodiments in which receiving cavity 135 retains sampling head 111, the volume of receiving cavity 135 may also be less than the volume of sampling head 111; at this point, less liquid is in receiving chamber 135, and more liquid is outside of receiving chamber 135, which is more advantageous for drawing liquid from sampling tube 130.

In some embodiments, there is a space between the securing member 133 and the bottom 131b, and the securing member 133 is secured to the tube wall 131 a. More specifically, the spacing between the securing member 133 and the base 131b is less than the length of the broken pledget 110 so that the broken pledget 110 can stand within the accommodation cavity 135. In an alternative specific example, the spacing between the fixture 133 and the bottom 131b is less than the height of the sampling head 111.

Specifically, the fixing member 133 has a first face 133a, the first face 133a faces the nozzle, and an angle (α in fig. 1) between the first face 133a and the axial direction of the tube body 131 is 45 ° to 90 °. By setting the angle between the first face 133a and the axial direction of the tube 131 to be 45 ° to 90 °, the swab 110 can be more easily introduced into the accommodation chamber 135 during centrifugation. Further, the angle between the first surface 133a and the axial direction of the tube 131 is 45 ° to 60 °. The fixing member 133 also has a second surface 133b, the second surface 133b is adjacent to the first surface 133a, the second surface 133b is spaced from the pipe wall 131a, the second surface 133b faces the pipe wall 131a, and an axial angle between the second surface 133b and the pipe body 131 is 0 ° to 90 °. In the embodiment shown in fig. 2, the second face 133b makes an angle of 0 ° with the axial direction of the tube body 131. That is, the axial direction of the tube body 131 is parallel to the first surface 133 a.

In some embodiments, the inner diameter at the receiving cavity 135 is greater at locations closer to the bottom. By setting the inner diameter of the accommodation chamber 135 to be larger as it is closer to the bottom, the sampling head 111 can be more firmly positioned within the accommodation chamber 135.

In some embodiments, the ratio of the maximum length (h 2 in fig. 1) of the fixing member 133 in the axial direction of the tube body 131 to the length (h 1 in fig. 1) of the tube body 131 is 1: (3-4). The ratio of the maximum length of the fixing member 133 in the axial direction of the tube body 131 to the length of the tube body 131 is set to 1: (3-4) it is possible to more firmly locate the sampling head 111 within the accommodation chamber 135.

In the present embodiment, the material of the tube body 131 is glass or plastic; the tube body 131 has a hollow cylindrical shape, an inner diameter (phi in fig. 1) of the tube body 131 is 13mm to 16mm, and a maximum length (b in fig. 1) of the fixing member 133 in an axial direction perpendicular to the tube body 131 is 8mm to 11mm; the maximum length (h 2 in fig. 1) of the fixing member 133 in the axial direction of the tube body 131 is 60mm to 110mm. Of course, in other embodiments, the material of the tube 131 is not limited to the above, and may be other materials. The dimensions of the tube body 131 and the fixing member 133 are not limited to the above, and may be adjusted according to actual conditions. As long as the accommodating cavity 135 formed by the tube body 131 and the fixing member 133 accommodates the swab 110, an included angle between the axial direction of the swab 110 and the axial direction of the tube body 131 is not more than 30 °.

In some embodiments, sampling tube 130 further comprises a cap 150, cap 150 for covering the orifice of tube 131 to seal tube 131. Further, the cover 150 is provided with a sampling mark 151, and when the tube 131 is in a sealed state, the front projection of the sampling mark 151 on the bottom 131b does not overlap with the front projection of the accommodating chamber 135 on the bottom 131b. According to the sampling mark portion 151 thus provided, the sampling needle of the automatic sampling apparatus can pass through the cover 150 so as to avoid the swab 110 when sampling by the automatic sampling apparatus, and the liquid in the sampling tube 130 can be sucked.

In this embodiment, swab 110 is packaged separately from sampling tube 130 and, when in use, is used in a kit. Of course, in other embodiments, swab 110 and sampling tube 130 may be packaged together. At this time, a part of the swab 110 is accommodated in the tube 131, and when in use, the swab 110 is taken out of the sampling tube 130 and sampled.

In one embodiment, a preservation or lysis solution is pre-disposed in sampling tube 130. The preservation solution or the lysate is preset in the sampling tube 130, so that the pollution risk caused by uncapping can be reduced, and the pollution risk caused by the preservation solution or the lysate can be avoided. Of course, in other embodiments, no preservation or lysis fluid may be provided in sample tube 130. In this case, a preserving fluid or a lysis solution may be added to the sampling tube 130 when in use.

In some embodiments, the securing member 133 is a hollow structure. The hollow anchor 133 can reduce the weight of the sampling tube 130 and can also save materials.

Referring to fig. 3 and 4, in some embodiments, after insertion of sampling head 111 of swab 110 into receiving chamber 135, crease 114 is adjacent the orifice of sampling tube 130. So arranged, the centrifugation step can be omitted after sampling. That is, by inserting the swab 110 directly into the accommodating chamber 135 and breaking the swab 110 from the fold 114, it is possible to achieve that the axial direction of the swab 110 of the broken swab 110 does not exceed 30 ° with respect to the axial direction of the tube 131, and centrifugation is not necessary. In an alternative specific example, when sampling head 111 is received in receiving cavity 135, crease 114 is a distance from bottom 131b of sampling tube 130 that is the maximum depth of sampling tube 130. That is, after the sampling head 111 of the swab 110 is inserted into the receiving chamber 135 and the swab 110 is broken off from the crease 114, the broken swab 110 located in the sampling tube 130 is flush with the nozzle at the end near the nozzle. In another alternative specific example, after the sampling head 111 of the swab 110 is inserted into the receiving chamber 135 and the swab 110 is broken off from the crease 114, the broken-off swab 110 located in the sampling tube 130 protrudes from the nozzle of the sampling tube 130 near the end of the nozzle, at this time, as long as the cover 150 can cover the nozzle of the tube 131 and seal the tube 131.

The sampling assembly 10 described above may be used for sampling viruses. In use, the sampling assembly 10 described above opens the cap 150 after sampling the swab 110, breaks the swab 110 by means of the tube wall 131a, and drops the portion with the sampling head 111 into the tube 131; after the tube 131 is sealed by the cover 150, the tube 131 is centrifuged, so that the sampling head 111 of the swab 110 in the tube 131 falls into the accommodating cavity 135, and more operation space is provided in the tube 131.

Referring to fig. 5, another sampling assembly 20 according to an embodiment of the present application is provided, and the sampling assembly 20 has substantially the same structure as the sampling assembly 10, except that in the sampling assembly 20, the side surface of the fixing member 233 is completely spaced from the pipe wall 231a, so that the accommodating cavity 235 can accommodate a plurality of swabs 210, for example, five, eight or ten swabs 210 simultaneously. That is, the surfaces of the fixing members 233 facing the pipe wall 231a are spaced apart from the pipe wall 231 a. Alternatively, the fixing member 233 has a columnar shape, such as a cylinder, a quadrangular prism, a triangular prism, or the like. At this time, the shape of the accommodation chamber 235 accommodating the swab 210 formed by the fixing member 233 together with the tube wall 231a and the bottom 231b changes according to the shape of the fixing member 233 and the tube body, for example, in a solid ring shape. Besides the advantages of the sampling assembly 10, the above-mentioned sampling assembly 20 can enable more swabs 210 to be contained in the sampling tube by completely spacing the side surface of the fixing piece 233 from the tube wall 231a, so as to realize mixed sampling, improve the efficiency of sampling and detection, and facilitate large-scale screening.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.

Claims

1. A sampling tube, comprising:

The fixing piece is positioned in the pipe body and is close to the bottom, the fixing piece, the pipe wall part and the bottom form a containing cavity for containing the swab, and when the swab is contained in the containing cavity, the axial direction of the swab is the same as that of the pipe body;

the ratio of the maximum length of the fixing piece in the axial direction of the pipe body to the length of the pipe body is 1/4-1/3;

the pipe body is provided with a pipe orifice, the fixing piece is provided with a first surface, the first surface faces the pipe orifice, and an included angle between the first surface and the axial direction of the pipe body is 45-90 degrees;

the fixing piece is further provided with a second surface, the second surface is adjacent to the first surface, the second surface is spaced from the pipe wall, the second surface faces the pipe wall, and an included angle between the second surface and the axial direction of the pipe body is 0 degree;

the pipe body is hollow and cylindrical, the inner diameter of the pipe body is 13 mm-16 mm, and the maximum length of the fixing piece in the axial direction perpendicular to the pipe body is 8 mm-11 mm;

the fixing piece is arranged on the bottom, one side of the fixing piece is spaced from the pipe wall, and the accommodating cavity can accommodate the sampling head of the swab and is matched with the inner side of the pipe wall to clamp the sampling head; or the fixing piece is arranged on the bottom, and the surfaces of the fixing piece facing the pipe wall parts are all spaced from the pipe wall parts, so that the accommodating cavity can accommodate a plurality of swabs at the same time;

the sampling tube also comprises a cover body, wherein the cover body is used for covering the tube orifice of the tube body so as to seal the tube body; the cover body is provided with a sampling mark part, and when the pipe body is in a sealing state, the orthographic projection of the sampling mark part on the bottom and the orthographic projection of the accommodating cavity on the bottom are not overlapped.

2. The sampling tube of claim 1, wherein the first face is at an angle of 45 ° to 60 ° to the axial direction of the tube body.

3. A sampling assembly comprising the sampling tube of claim 1 or 2 and a swab which, when received in the receiving cavity of the sampling tube, has an axial direction which is the same as the axial direction of the body of the sampling tube.

4. A sampling assembly according to claim 3, wherein the swab comprises a sampling stem having a crease therein, the crease being adjacent the mouth of the sampling tube after insertion of the swab into the receiving chamber.