CN112704518A

CN112704518A - Sampling tube and sampling assembly

Info

Publication number: CN112704518A
Application number: CN202011278044.2A
Authority: CN
Inventors: 顾大勇; 樊冰; 刘秀卿; 余叠传; 阎清茹; 张海燕
Original assignee: Shenzhen Second Peoples Hospital
Current assignee: Shenzhen Maijia Biomedical Co ltd
Priority date: 2020-11-16
Filing date: 2020-11-16
Publication date: 2021-04-27
Anticipated expiration: 2040-11-16
Also published as: CN112704518B

Abstract

The invention relates to a sampling tube and a sampling assembly. This sampling pipe includes body and mounting, and the body has wall of a tube portion and with wall of a tube portion sealing connection's bottom, and the mounting is located the body and is close to the bottom, and the mounting forms the chamber that holds of acceping the swab with wall of a tube portion and bottom together, and when the chamber was held in holding to the swab, the axial of swab and the axial contained angle of body were no more than 30. When in use, the sampling tube is convenient for sucking the liquid in the sampling tube.

Description

Sampling tube and sampling assembly

Technical Field

The invention relates to the field of medical instruments, in particular to a sampling tube and a sampling assembly.

Background

The traditional sampler used clinically comprises a sampling swab and a sampling tube, and the sampling tube is mostly adopted

(1A0-16) × (6-10) mm plastic or glass tube is generally filled with 1-10 mL of a preservative solution or a lysis solution to maintain the activity of a sample collected by a sampling swab or to simply pretreat the sample. When the sampling tube is used, a sampling head of the sampling swab is used for sampling at a corresponding position, then the sampling head with the sample is placed into the sampling tube, the sampling swab is broken off, the sampling head with the sample falls into preservation solution or lysis solution in the sampling tube, and then a tube cover of the sampling tube is screwed for standby inspection. During detection, the preservation solution or the lysis solution soaked in the sampling head with the sample needs to be sucked out.

However, in the sampling tube of the conventional sampler, the broken sampling swab is liable to obstruct the absorption of the preservative solution or the lysate in the sampling tube, and the phenomenon of sample failure or insufficient sample absorption is liable to occur. In the face of the above problems, the current main treatment is to pick up the broken swab and then pipette it, but this increases the risk of contamination of the sample and infection of the user.

Disclosure of Invention

Therefore, a need exists for a sampling tube which is not prone to sample failure or insufficient sample suction, and which is not prone to contamination of the sample and has high safety.

A sampling tube, comprising:

a tube body having a tube wall portion and a bottom portion sealingly connected to the tube wall portion; and

the fixing piece is located in the tube body and close to the bottom of the tube body, a containing cavity for containing a swab is formed by the fixing piece, the wall portion of the tube body and the bottom of the tube body, and when the swab is contained in the containing cavity, an included angle between the axial direction of the swab and the axial direction of the tube body is not more than 30 degrees.

According to the sampling tube, the fixing part is arranged in the tube body, so that the fixing part and the tube wall part and the bottom of the tube body form the accommodating cavity for accommodating the swab together, when the sampling tube is used, the accommodating cavity can accommodate the swab, and the included angle between the axial direction of the swab and the axial direction of the tube body is not more than 30 degrees, so that enough space is formed in the tube body for liquid suction in the tube body, the sampling tube is not easily obstructed by the swab during liquid suction, and the situations that the sampling cannot be performed or the sampling is insufficient are not easy to occur; at the same time, the risk of contamination of the sample and infection of the user is reduced, since the swab does not need to be carried out.

In one embodiment, the swab has an axial direction that is the same as an axial direction of the tube when the swab is received in the receiving cavity.

In one embodiment, the fixing member is disposed on the bottom and one side of the fixing member is spaced from the tube wall, and the receiving cavity can receive the sampling head of the swab and cooperate with the inner side of the tube wall to hold the sampling head.

In one embodiment, the tube body is provided with a tube opening, the fixing part is provided with a first surface, the first surface faces the tube opening, and an included angle between the first surface and the axial direction of the tube body is 45-90 degrees.

In one embodiment, the fixing member has a second surface adjacent to the first surface and spaced from the pipe wall, and the second surface forms an angle of 0 ° to 90 ° with respect to an axial direction perpendicular to the pipe body.

In one embodiment, the ratio of the maximum length of the fixing member to the length of the pipe body in the axial direction of the pipe body is 1: (3-4).

In one embodiment, the inner diameter of the pipe body is 13 mm-16 mm, and the maximum length of the fixing piece in the axial direction perpendicular to the pipe body is 8 mm-11 mm.

In one embodiment, the sampling tube further comprises a cover body for covering the nozzle of the tube body so as to seal the tube body.

In one embodiment, the cover body is provided with a sampling mark part, and when the tube body is in a sealed state, an orthographic projection of the sampling mark part on the bottom part is not overlapped with an orthographic projection of the accommodating cavity on the bottom part.

A sampling assembly comprises the sampling tube and the swab, and when the swab is accommodated in the accommodating cavity of the sampling tube, the included angle between the axial direction of the swab and the axial direction of the tube body of the sampling tube is not more than 30 degrees.

In one embodiment, the swab includes a sampling handle having a fold therein, the fold being proximate to a nozzle of the sampling tube upon insertion of the swab into the receiving cavity.

Drawings

One or more embodiments are illustrated by corresponding figures in the drawings, which are not to be construed as limiting the embodiments, unless expressly stated otherwise, and the drawings are not to scale.

FIG. 1 is a schematic view of a sampling assembly of an embodiment prior to centrifugation;

FIG. 2 is a schematic view of the sampling assembly shown in FIG. 1 after centrifugation;

FIG. 3 is a schematic view of a sampling assembly of another embodiment;

FIG. 4 is a schematic view of the swab break-off of the sampling assembly of FIG. 3;

FIG. 5 is a schematic diagram of a sampling assembly of another embodiment.

Reference numerals:

10. a sampling component; 110. a swab; 130. a sampling tube; 111. a sampling head; 113. a sampling handle; 131. a pipe body; 133. a fixing member; 131a, a tube wall portion; 131b, a bottom; 135. an accommodating chamber; 133a, a first face; 133b, a second face; 150. a cover body; 151. a sampling mark section; 114. and (6) folding.

20. A sampling component; 210. a swab; 233. a fixing member; 231a, a tube wall portion; 231b, bottom; 235. a receiving cavity.

Detailed Description

The present invention will now be described more fully hereinafter for purposes of facilitating an understanding thereof, and may be embodied in many different forms and are not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may be present. When the terms "vertical," "horizontal," "left," "right," "upper," "lower," "inner," "outer," "bottom," and the like are used to indicate an orientation or positional relationship, it is for convenience of description only based on the orientation or positional relationship shown in the drawings, and it is not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered limiting of the present application. Furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

Referring to fig. 1 and 2, one embodiment of the present invention provides a sampling assembly 10, the sampling assembly 10 including a swab 110 and a sampling tube 130.

In particular, the swab 110 is used for sampling. The swab 110 has a generally rod-like shape. The swab 110 includes a sampling head 111 and a sampling handle 113 connected to the sampling head 111. The sampling head 111 is a portion that directly contacts the sampling site at the time of sampling. In an alternative specific example, the sampling head 111 is spherical or ellipsoidal. It is understood that the shape of the sampling head 111 is not limited to spherical or ellipsoidal, and may be other shapes. The sampling handle 113 has a hand-held portion thereon that is remote from the sampling head 111. In use, the hand-held portion is held for sampling. In the present embodiment, the sampling handle 113 further has a fold 114, the fold 114 is close to the sampling head 111, and the portion with the sampling head 111 can be completely accommodated in the tube 131 after the swab 110 is broken by the fold 114. The provision of the fold 114 makes it easier for the swab 110 to break off and also reduces the risk of contamination of the sample since the hand-held portion of the swab 110 does not fall into the tube 131.

Specifically, the sampling tube 130 includes a tube body 131 and a fixture 133 positioned within the tube body 131. The tube body 131 comprises a tube wall part 131a and a bottom part 131b, wherein the tube wall part 131a and the bottom part 131b are hermetically connected to form a cavity capable of containing liquid (such as preserving fluid or lysis fluid); of course, the tube 131 has a nozzle, which is far from the bottom 131 b. In the present embodiment, the tube wall 131a has a hollow cylindrical shape, and the bottom 131b has a certain curvature. In the embodiment shown in fig. 1, the bottom 131b projects away from the spout. Of course, in other embodiments, the tube wall portion 131a is not limited to a hollow cylinder, but may be other hollow structures, such as a hollow rectangular parallelepiped. The bottom 131b may also be non-curved, i.e. flat.

Specifically, the fixing member 133 is located in the cavity formed by the tube wall portion 131a and the bottom portion 131b and close to the bottom portion 131b, and the fixing member 133 forms an accommodating cavity 135 for accommodating the swab 110 together with the tube wall portion 131a and the bottom portion 131 b. When the swab 110 is accommodated in the accommodating cavity 135, the angle between the axial direction of the swab 110 and the axial direction of the tube 131 is not more than 30 °. For example, 2 °, 5 °, 8 °, 10 °, 12 °, 15 °, 18 °, 20 °, 25 °, or 28 °, etc. When the swab 110 is accommodated in the accommodating cavity 135 and the included angle between the axial direction of the swab 110 and the axial direction of the tube body 131 does not exceed 30 °, sufficient operating space can be reserved for sucking the liquid in the sampling tube 130, so that the liquid in the sampling tube 130 can be sucked. Note that, the axial direction of the pipe 131 herein refers to a direction that is the same as the central axis of the pipe 131; the axial direction of the swab 110 herein refers to a direction that is coaxial with the central axis of the swab 110. In fig. 1, the axial direction of the tube 131 is in the vertical direction, and the axial direction of the swab 110 is the same as the longitudinal direction of the swab 110.

Further, when the swab 110 is accommodated in the accommodating cavity 135, an angle between the axial direction of the swab 110 and the axial direction of the tube 131 is 0 ° to 10 °. Further, when the swab 110 is accommodated in the accommodating cavity 135, an included angle between the axial direction of the swab 110 and the axial direction of the tube 131 is 0 ° to 6 °. In the illustrated embodiment, the swab 110 has an axial direction that is the same as the axial direction of the tube 131 when the swab 110 is received in the receiving cavity 135. That is, when the swab 110 is accommodated in the accommodating cavity 135, an angle formed between the axial direction of the swab 110 and the axial direction of the tube 131 is 0 °.

In some embodiments, the fixing member 133 is disposed on the bottom portion 131b and a portion of the side surface of the fixing member 133 is spaced apart from the tube wall portion 131 a. In the illustrated embodiment, the fixing member 133 is disposed on the bottom portion 131b and one side of the fixing member 133 is spaced apart from the tube wall portion 131a to form an accommodating cavity 135 with the tube wall portion 131a and the bottom portion 131 b. Further, the fixing member 133 is fixed to the surface of the bottom portion 131b with one side of the fixing member 133 spaced apart from the pipe wall portion 131 a.

In some embodiments, the receiving cavity 135 can completely receive the sampling head 111 within the receiving cavity 135. Optionally, in the case that the shape of the accommodating cavity 135 is substantially the same as the shape of the sampling head 111, the volume of the accommodating cavity 135 is equal to or slightly larger than the volume of the sampling head 111 (e.g., the ratio of the volume of the sampling head 111 to the volume of the accommodating cavity 135 is 1: 1.05-1.1). The arrangement can enable the sampling head 111 to enter the accommodating cavity 135, but the liquid in the accommodating cavity 135 is not too much, so that the liquid taking is inconvenient. Of course, in other embodiments, the receiving cavity 135 can also be capable of partially receiving the sampling head 111, as long as the swab 110 can be accommodated in the receiving cavity 135, and the included angle between the axial direction of the swab 110 and the axial direction of the tube 131 is not more than 30 °, so as to reserve more space for sucking the liquid in the sampling tube 130.

Further, the receiving cavity 135 can also retain the sampling head 111 in the receiving cavity 135. By retaining sampling head 111 in cavity 135 via cavity 135, sampling head 111 is prevented from sliding out of cavity 135 and tilting outside of cavity 135, impeding the aspiration of liquid from sampling tube 130. Of course, in embodiments where the receiving chamber 135 retains the sampling head 111, the volume of the receiving chamber 135 may also be less than the volume of the sampling head 111; now, less liquid is in chamber 135, and more liquid is outside chamber 135, which is more favorable for sucking up liquid in sampling tube 130.

In some embodiments, the fixing member 133 is spaced apart from the bottom portion 131b, and the fixing member 133 is fixed to the tube wall portion 131 a. More specifically, the spacing between the securing member 133 and the bottom 131b is less than the length of the broken swab 110 to enable the broken swab 110 to stand within the receiving cavity 135. In an alternative specific example, the spacing between fixture 133 and bottom 131b is less than the height of sampling head 111.

Specifically, the fixing member 133 has a first surface 133a, the first surface 133a faces the nozzle, and an included angle (α in fig. 1) between the first surface 133a and the axial direction of the pipe 131 is 45 ° to 90 °. By setting the included angle between the first surface 133a and the axial direction of the tube 131 to 45 ° to 90 °, the swab 110 can enter the accommodating cavity 135 more easily during centrifugation. Further, an included angle between the first surface 133a and the axial direction of the pipe 131 is 45 ° to 60 °. The fixing member 133 also has a second surface 133b, the second surface 133b is adjacent to the first surface 133a, the second surface 133b is spaced from the tube wall 131a, the second surface 133b faces the tube wall 131a, and an axial included angle between the second surface 133b and the tube 131 is 0-90 °. In the embodiment shown in fig. 2, the second surface 133b forms an angle of 0 ° with the axial direction of the pipe 131. That is, the axial direction of the pipe 131 is parallel to the first surface 133 a.

In some embodiments, the inner diameter of the receiving cavity 135 is larger closer to the bottom. By providing the inner diameter of the receiving cavity 135 to be larger closer to the bottom, the sampling head 111 can be made to be more firmly located within the receiving cavity 135.

In some embodiments, the ratio of the maximum length (h 2 in fig. 1) of the fixing member 133 to the length (h 1 in fig. 1) of the tube 131 in the axial direction of the tube 131 is 1: (3-4). The ratio of the maximum length of the fixing member 133 in the axial direction of the pipe body 131 to the length of the pipe body 131 is set to 1: (3-4), the sampling head 111 can be more firmly positioned in the accommodating cavity 135.

In this embodiment, the tube 131 is made of glass or plastic; the pipe body 131 is hollow cylindrical, the inner diameter (phi in fig. 1) of the pipe body 131 is 13mm to 16mm, and the maximum length (b in fig. 1) of the fixing member 133 in the axial direction perpendicular to the pipe body 131 is 8mm to 11 mm; the maximum length (h 2 in fig. 1) of the fixing member 133 in the axial direction of the pipe body 131 is 60mm to 110 mm. Of course, in other embodiments, the material of the tube 131 is not limited to the above, and may be other materials. The sizes of the tube 131 and the fixing member 133 are not limited to the above, and may be adjusted according to actual conditions. As long as the receiving cavity 135 formed by the tube 131 and the fixing element 133 receives the swab 110, the included angle between the axial direction of the swab 110 and the axial direction of the tube 131 does not exceed 30 °.

In some embodiments, the sampling tube 130 further comprises a cover 150, and the cover 150 is used for covering the nozzle of the tube 131 to seal the tube 131. Further, the cover 150 is provided with a sampling mark portion 151, and when the tube 131 is in a sealed state, an orthographic projection of the sampling mark portion 151 on the bottom 131b does not overlap with an orthographic projection of the accommodating chamber 135 on the bottom 131 b. By providing the sampling mark 151 in this manner, when sampling is performed by the automatic sampling device, the sampling needle of the automatic sampling device can pass through the cover 150 while avoiding the swab 110, and thereby the liquid in the sampling tube 130 can be sucked.

In this embodiment, the swab 110 is packaged separately from the sampling tube 130 and, in use, is used in a kit. Of course, in other embodiments, the swab 110 and the sampling tube 130 may be packaged together. At this time, a part of the swab 110 is accommodated in the tube 131, and the swab 110 is taken out of the sampling tube 130 and sampled when used.

In one embodiment, the sample tube 130 is pre-filled with a preservative or lysing solution. The preservation solution or the lysis solution is pre-arranged in the sampling tube 130, so that the pollution risk caused by uncovering can be reduced, and the pollution risk caused by the preservation solution or the lysis solution can also be avoided. Of course, in other embodiments, the storage solution or the lysis solution may not be pre-disposed in the sampling tube 130. In this case, when used, a storage solution or a lysis solution may be added to the sampling tube 130.

In some embodiments, the fixing member 133 is a hollow structure. The hollow fixture 133 reduces the weight of the sampling tube 130 and also saves material.

Referring to fig. 3 and 4, in some embodiments, after inserting the sampling head 111 of the swab 110 into the receiving cavity 135, the fold 114 is adjacent to the orifice of the sampling tube 130. So configured, can make the centrifugation step omitted after taking a sample. That is, by inserting the swab 110 directly into the receiving cavity 135 and breaking the swab 110 at the fold 114, the angle between the axial direction of the swab 110 and the axial direction of the tube 131 after breaking can be no more than 30 degrees, and centrifugation is not necessary. In an alternative specific example, fold 114 is spaced from bottom 131b of sampling tube 130 by the maximum depth of sampling tube 130 when sampling head 111 is received in cavity 135. That is, after inserting the sampling head 111 of the swab 110 into the receiving cavity 135 and breaking the swab 110 off of the fold 114, the end of the broken swab 110 in the sampling tube 130 adjacent the nozzle is flush with the nozzle. In another alternative embodiment, after inserting the sampling head 111 of the swab 110 into the receiving cavity 135 and breaking the swab 110 off the fold 114, the broken end of the swab 110 in the sampling tube 130 near the nozzle protrudes beyond the nozzle of the sampling tube 130, so long as the cover 150 can cover the nozzle of the tube 131 and seal the tube 131.

The sampling assembly 10 described above may be used for sampling viruses. In the use of the sampling unit 10, after the swab 110 has been sampled, the cover 150 is opened, the swab 110 is broken by the tube wall 131a, and the portion with the sampling head 111 is dropped into the tube 131; then, after sealing the tube 131 with the cover 150, the tube 131 is centrifuged, so that the sampling head 111 of the swab 110 in the tube 131 falls into the receiving cavity 135, thereby allowing more operating space in the tube 131.

Referring to fig. 5, another sampling assembly 20 is provided in accordance with an embodiment of the present invention, the sampling assembly 20 being substantially the same as the sampling assembly 10 except that in the sampling assembly 20, the side surface of the fixing member 233 is completely spaced from the tubular wall portion 231a so that the receiving cavity 235 can simultaneously receive a plurality of swabs 210, for example, five, eight or ten swabs 210. That is, the surfaces of the fixing members 233 facing the tube wall portion 231a are all spaced apart from the tube wall portion 231 a. Alternatively, the fixing member 233 has a cylindrical shape, such as a cylinder, a quadrangular prism, a triangular prism, or the like. At this time, the shape of the receiving cavity 235 formed by the fixing member 233 together with the tube wall 231a and the bottom 231b for receiving the swab 210 changes according to the shape of the fixing member 233 and the tube body, and is, for example, a three-dimensional ring shape. The sampling assembly 20 has the advantages of the sampling assembly 10, and the side surface of the fixing member 233 is completely separated from the pipe wall 231a, so that more swabs 210 can be accommodated in the sampling pipe, mixed sampling is realized, the sampling and detection efficiency is improved, and large-scale screening is facilitated.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A sampling tube, comprising:

the fixing piece is positioned in the tube body and close to the bottom, the fixing piece, the tube wall part and the bottom form a containing cavity for containing a swab, and when the swab is contained in the containing cavity, the included angle between the axial direction of the swab and the axial direction of the tube body is not more than 30 degrees.

2. The sampling tube of claim 1, wherein an axial direction of the swab is the same as an axial direction of the tube when the swab is received in the receiving cavity.

3. The sampling tube of claim 2, wherein said fixing member is disposed on said bottom portion and one side of said fixing member is spaced from said tube wall portion, and said receiving cavity is capable of receiving a sampling head of said swab and engaging an inner side of said tube wall portion to retain said sampling head.

4. The sampling tube of claim 2, wherein the retainer is disposed on the base and the faces of the retainer facing the tube wall are each spaced from the tube wall.

5. The sampling tube according to any one of claims 1 to 4, wherein the tube body has a nozzle, the fixing member has a first surface facing the nozzle, and the first surface forms an angle of 45 ° to 90 ° with the axial direction of the tube body.

6. The sampling tube of claim 5, wherein the retainer has a second face adjacent to the first face, the second face being spaced from the tube wall, the second face being angled from 0 ° to 90 ° from an axis perpendicular to the tube wall;

or, the ratio of the maximum length of the fixing piece in the axial direction of the pipe body to the length of the pipe body is 1: (3-4).

7. The sampling tube as claimed in claim 6, wherein the tube body has a hollow cylindrical shape, the inner diameter of the tube body is 13mm to 16mm, and the maximum length of the fixing member in the axial direction perpendicular to the tube body is 8mm to 11 mm.

8. The sampling tube of claim 1, further comprising a cap for covering the nozzle of the tube body to seal the tube body;

optionally, a sampling mark portion is arranged on the cover body, and when the tube body is in a sealed state, an orthographic projection of the sampling mark portion on the bottom and an orthographic projection of the accommodating cavity on the bottom do not overlap.

9. A sampling assembly comprising a sampling tube according to any of claims 1 to 8 and a swab, wherein the swab, when received in the receiving cavity of the sampling tube, has an axial direction which does not include more than 30 ° from an axial direction of the body of the sampling tube.

10. The sampling assembly of claim 9, wherein the swab includes a sampling handle having a fold therein, the fold being proximate to a nozzle of the sampling tube upon insertion of the swab into the receiving cavity.