CN112703198B - 用于跨血脑屏障递送试剂的方法和组合物 - Google Patents
用于跨血脑屏障递送试剂的方法和组合物 Download PDFInfo
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- CN112703198B CN112703198B CN201980059342.1A CN201980059342A CN112703198B CN 112703198 B CN112703198 B CN 112703198B CN 201980059342 A CN201980059342 A CN 201980059342A CN 112703198 B CN112703198 B CN 112703198B
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202510648887.3A CN120843603A (zh) | 2018-07-11 | 2019-07-11 | 用于跨血脑屏障递送试剂的方法和组合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696422P | 2018-07-11 | 2018-07-11 | |
| US62/696,422 | 2018-07-11 | ||
| PCT/US2019/041386 WO2020014471A1 (en) | 2018-07-11 | 2019-07-11 | Methods and compositions for delivery of agents across the blood-brain barrier |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN202510648887.3A Division CN120843603A (zh) | 2018-07-11 | 2019-07-11 | 用于跨血脑屏障递送试剂的方法和组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112703198A CN112703198A (zh) | 2021-04-23 |
| CN112703198B true CN112703198B (zh) | 2025-05-30 |
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| CN201980059342.1A Active CN112703198B (zh) | 2018-07-11 | 2019-07-11 | 用于跨血脑屏障递送试剂的方法和组合物 |
| CN202510648887.3A Pending CN120843603A (zh) | 2018-07-11 | 2019-07-11 | 用于跨血脑屏障递送试剂的方法和组合物 |
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| CN202510648887.3A Pending CN120843603A (zh) | 2018-07-11 | 2019-07-11 | 用于跨血脑屏障递送试剂的方法和组合物 |
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| JP (2) | JP2021530218A (cg-RX-API-DMAC10.html) |
| CN (2) | CN112703198B (cg-RX-API-DMAC10.html) |
| CA (1) | CA3105381A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2020014471A1 (cg-RX-API-DMAC10.html) |
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| WO2019200016A1 (en) | 2018-04-10 | 2019-10-17 | President And Fellows Of Harvard College | Aav vectors encoding clarin-1 or gjb2 and uses thereof |
| JP2021530218A (ja) * | 2018-07-11 | 2021-11-11 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 血液脳関門を超える薬剤の送達のための方法および組成物 |
| CN113166208B (zh) | 2018-10-02 | 2024-11-22 | 沃雅戈治疗公司 | 重新定向aav衣壳的嗜性 |
| AU2020214831B2 (en) * | 2019-01-30 | 2025-09-25 | The Broad Institute, Inc. | Systems for evolved adeno-associated viruses (AAVs) for targeted delivery |
| CN115023242B (zh) * | 2019-11-22 | 2025-03-14 | 费城儿童医院 | 腺相关病毒载体变体 |
| CA3167290A1 (en) | 2020-01-10 | 2021-07-15 | The Brigham And Women's Hospital, Inc. | Methods and compositions for delivery of immunotherapy agents across the blood-brain barrier to treat brain cancer |
| FI4103214T3 (fi) | 2020-02-13 | 2026-07-03 | Tenaya Therapeutics Inc | Geeniterapian vektorit sydänsairauden hoitoon |
| AU2021265832A1 (en) | 2020-04-29 | 2022-11-24 | The Broad Institute, Inc. | Machine learning accelerated protein engineering through fitness prediction |
| US12630842B2 (en) * | 2020-05-13 | 2026-05-19 | Voyager Therapeutics, Inc. | Redirection of tropism of AAV capsids |
| EP4199972A4 (en) * | 2020-08-21 | 2025-01-15 | Capsida, Inc. | ADENO-ASSOCIATED VIRUS COMPOSITIONS WITH PREFERRED EXPRESSION LEVELS |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| CN112194706B (zh) * | 2020-09-30 | 2022-03-08 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| AU2022266615A1 (en) * | 2021-04-27 | 2023-11-09 | The General Hospital Corporation | Aav capsids and uses thereof |
| WO2022272240A2 (en) * | 2021-06-21 | 2022-12-29 | The Brigham And Women’S Hospital, Inc. | Adeno-associated viral (aav) vectors for tissue-targeted expression of therapeutic genes |
| KR102934033B1 (ko) * | 2021-10-01 | 2026-03-06 | 서울대학교산학협력단 | 혈액 뇌장벽 투과용 펩타이드 및 이의 용도 |
| KR20240095539A (ko) | 2021-10-08 | 2024-06-25 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 변이체 및 이의 사용 방법 |
| EP4426716A1 (en) | 2021-11-02 | 2024-09-11 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
| CN114606264B (zh) * | 2022-03-22 | 2025-08-26 | 三峡大学 | 一种用于神经系统药物递送的aav病毒载体 |
| WO2023240236A1 (en) * | 2022-06-10 | 2023-12-14 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of spinal muscular atrophy related disorders |
| JP2026509271A (ja) | 2023-03-10 | 2026-03-17 | ダイノ セラピューティクス,インコーポレーテッド | カプシドポリペプチドおよびその使用方法 |
| WO2024229777A1 (zh) * | 2023-05-11 | 2024-11-14 | 深圳先进技术研究院 | 一种aav载体及其应用 |
| WO2024249810A2 (en) * | 2023-06-02 | 2024-12-05 | The Brigham And Women's Hospital, Inc. | Combinatory use of adeno-associated viruses and focused ultrasound for overcoming the blood-brain barrier |
| TW202515898A (zh) | 2023-06-30 | 2025-04-16 | 日商武田藥品工業股份有限公司 | Htt抑制物及其用途 |
| CN116808231B (zh) * | 2023-07-07 | 2024-03-26 | 中国药科大学 | 一种细胞穿膜肽偶联舒必利前药体系以及制备方法和应用 |
| CN117964715B (zh) * | 2023-07-21 | 2025-01-24 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| KR20260082361A (ko) | 2023-08-31 | 2026-06-04 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 폴리펩타이드 및 이의 사용 방법 |
| WO2025076091A1 (en) * | 2023-10-03 | 2025-04-10 | Brave Bio, Inc. | Cd20 antibody aav vectors and methods of use thereof |
| TW202535908A (zh) * | 2023-11-02 | 2025-09-16 | 美商渤健麻塞諸塞州股份有限公司 | 中樞神經系統靶向之aav衣殼之重定向 |
| TW202545971A (zh) | 2024-02-08 | 2025-12-01 | 美商戴諾治療公司 | 殼體多肽及其使用方法 |
| WO2025231400A1 (en) | 2024-05-03 | 2025-11-06 | Sangamo Therapeutics, Inc. | Synthetic transcription factors and methods of making and using thereof |
| WO2026064442A2 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2026122963A1 (en) | 2024-12-06 | 2026-06-11 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
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