CN112695107B - Growth performance SNP locus combination of meat sheep and application thereof - Google Patents
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Abstract
The invention discloses a growth performance SNP locus combination of meat sheep and application thereof, relates to the technical field of gene breeding, and provides 2036 SNP loci, wherein physical position information of the SNP loci is determined based on sheep v4.0 genome sequence comparison, the SNP loci are SNP0001-SNP2036, and the sheep individuals are subjected to genetic evaluation based on 2036 SNP loci, so that individual selection can be performed on growth traits which are difficult to measure in the early stage, the generation interval is shortened, the breeding process is accelerated, and a great amount of breeding cost is saved.
Description
Technical Field
The invention relates to the technical field of biology, in particular to a growth performance SNP locus combination of a meat sheep and application thereof.
Background
Sheep are the first domesticated animals and the most common bred animals in China, and with the activity and selection of human beings, sheep varieties with different high-quality resources are gradually formed, however, in actual production, the varieties of sheep at home and abroad are various, the individual difference is large, and the variety with specific target characters needs to be selected for breeding production, so that the acquisition of higher economic value or market benefit becomes one of the great problems in sheep breeding.
In the history of sheep selective breeding, the exploration from empirical breeding to breeding theory and method is performed, and the selective theory, the pure line theory, backcross breeding, recurrent breeding, mutation breeding, single seed transmission and ideal plant type are provided; further to marker assisted selection breeding, a variety of markers have been explored, such as amplified fragment length polymorphism marker assisted selection (AFLP), microsatellite marker assisted selection (SSR), and single nucleotide polymorphism marker assisted Selection (SNP).
At present, the molecular marker technology is more and more emphasized due to its advantages of high accuracy, strong operability, etc., and among them, the molecular marker technology based on Single Nucleotide Polymorphisms (SNPs) is more and more widely applied. SNP is taken as a genetic molecular marker in biological genomes, and plays more and more important roles in the aspects of animal and plant genetic evolution analysis, important economic shape screening, molecular breeding and the like. The SNP chip based on the SNP is a convenient and efficient tool for modern genetic breeding, and is easy to realize high-throughput and automatic detection of the SNP, can detect the change of each base pair on genomic DNA, including insertion, deletion, inversion, conversion and the like, becomes an ideal SNP detection technology, and is increasingly applied to the field of sheep breeding.
The current commercial SNP chips of Sheep are Illumina provine SNP50 Beadchip (50K), Illumina sheet HD Genotyping Beadchip (680K) and Illumina provine LD (5K), the former two of which are the most commonly used in academic production research. The Illumina orange SNP50 Beadchip is developed by Illumina company and research teams and institutions such as UCSC, CSIRO, USDA and Agreearch, comprises more than 54K SNP sites covering the whole genome of sheep, and can be used for the research of genetic breeding, whole genome association analysis, quantitative trait locus positioning, gene optimization, comparative genomics and the like. The Illumina sheet HD Genotyping foundry (680K) is an SNP chip produced by Illumina company, and is a high-density chip amplified by the International Sheep genome Association (ISGC) on the basis of the Ovine SNP 50. However, the existing sheep SNP chip is mainly based on data of western sheep, lacks of SNP data of combination of Chinese sheep varieties and foreign sheep varieties, has the problems of insufficient site uniformity, insufficient embodiment of functional sites and regions, extremely low frequency sites of over 10 percent of sites in Chinese sheep groups and the like, and has very important significance in designing the SNP chip which is suitable for Chinese sheep groups and can rapidly and effectively detect growth functions.
Disclosure of Invention
In order to meet the requirements of chip site function detection and function research on growth performance direction in current breeding production in China, the invention provides high-depth whole genome resequencing data based on 16 wild sheep (Asia Mufolen) and 232 family sheep individuals in the world, a meat sheep growth performance SNP site which is accurate in detection, convenient to use and wide in market prospect is obtained by taking a sheep v4.0 genome as reference and combining with the existing research related to sheep growth function, and the site can be used for screening sheep varieties, identifying the sheep varieties, breeding the sheep, protecting germplasm resources and improving germplasm resources.
To achieve the technical object of the present invention, in a first aspect, the present invention provides a SNP site combination for growth performance of meat sheep, wherein the SNP site combination is included in a gene fragment of PECR, CSRP2, GRTP1, KIAA1217, EIF4G2, PHLPP1, ZNF687, LMBR1, FLNB, LINGO2, POLR 1A.
Wherein, the site combination comprises 2036 SNP sites, and the physical position information is determined based on sheep v4.0 genome sequence alignment, which is specifically shown in Table 1.
TABLE 1 physical information of SNP site combinations for growth Performance of meat sheep
SNP0057 | 1 | 99996890 | G | A | SNP0736 | 4 | 117525323 | G | A | SNP1415 | 13 | 24403575 | T | C |
SNP0058 | 1 | 99998511 | C | T | SNP0737 | 4 | 117528328 | G | A | SNP1416 | 13 | 24404246 | T | G |
SNP0059 | 1 | 99999668 | G | C | SNP0738 | 4 | 117528349 | G | A | SNP1417 | 13 | 24404288 | G | T |
SNP0060 | 1 | 99999717 | A | C | SNP0739 | 4 | 117528443 | G | A | SNP1418 | 13 | 24405047 | A | G |
SNP0061 | 2 | 217025288 | C | T | SNP0740 | 4 | 117529086 | T | C | SNP1419 | 13 | 24405048 | A | T |
SNP0062 | 2 | 217028013 | A | G | SNP0741 | 4 | 117530219 | C | T | SNP1420 | 13 | 24406744 | A | T |
SNP0063 | 2 | 217028692 | G | A | SNP0742 | 4 | 117530281 | G | A | SNP1421 | 13 | 24409343 | T | C |
SNP0064 | 2 | 217029293 | A | G | SNP0743 | 4 | 117530468 | G | T | SNP1422 | 13 | 24409394 | C | T |
SNP0065 | 2 | 217029479 | G | C | SNP0744 | 4 | 117530876 | G | C | SNP1423 | 13 | 24409717 | T | C |
SNP0066 | 2 | 217031585 | T | C | SNP0745 | 4 | 117530919 | C | T | SNP1424 | 13 | 24410562 | T | C |
SNP0067 | 2 | 217032217 | C | T | SNP0746 | 4 | 117530932 | T | C | SNP1425 | 13 | 24410579 | G | A |
SNP0068 | 2 | 217034018 | A | G | SNP0747 | 4 | 117531020 | T | C | SNP1426 | 13 | 24410588 | A | G |
SNP0069 | 2 | 217036169 | T | C | SNP0748 | 4 | 117531025 | C | T | SNP1427 | 13 | 24410591 | C | T |
SNP0070 | 2 | 217036299 | G | A | SNP0749 | 4 | 117532229 | T | G | SNP1428 | 13 | 24410919 | C | A |
SNP0071 | 2 | 217036449 | T | C | SNP0750 | 4 | 117533289 | A | G | SNP1429 | 13 | 24412045 | T | C |
SNP0072 | 2 | 217036519 | T | C | SNP0751 | 4 | 117535830 | G | A | SNP1430 | 13 | 24412062 | T | C |
SNP0073 | 2 | 217036982 | A | C | SNP0752 | 4 | 117537427 | C | A | SNP1431 | 13 | 24412064 | A | G |
SNP0074 | 2 | 217037135 | A | G | SNP0753 | 4 | 117538426 | T | C | SNP1432 | 13 | 24412246 | C | T |
SNP0075 | 2 | 217037190 | T | C | SNP0754 | 4 | 117538946 | A | G | SNP1433 | 13 | 24413557 | C | T |
SNP0076 | 2 | 217037191 | G | A | SNP0755 | 4 | 117539298 | T | C | SNP1434 | 13 | 24414200 | C | T |
SNP0077 | 2 | 217037283 | C | T | SNP0756 | 4 | 117539360 | T | A | SNP1435 | 13 | 24414731 | G | A |
SNP0078 | 2 | 217037955 | G | A | SNP0757 | 4 | 117539428 | A | G | SNP1436 | 13 | 24414822 | G | A |
SNP0079 | 2 | 217037996 | T | C | SNP0758 | 4 | 117540208 | A | G | SNP1437 | 13 | 24415579 | C | A |
SNP0080 | 2 | 217038064 | T | C | SNP0759 | 4 | 117540333 | C | T | SNP1438 | 13 | 24417396 | C | T |
SNP0081 | 2 | 217038233 | G | A | SNP0760 | 4 | 117541451 | C | T | SNP1439 | 13 | 24417556 | T | A |
SNP0082 | 2 | 217038446 | T | C | SNP0761 | 4 | 117541487 | G | A | SNP1440 | 13 | 24417660 | A | C |
SNP0083 | 2 | 217038457 | A | T | SNP0762 | 4 | 117541506 | G | A | SNP1441 | 13 | 24417791 | T | C |
SNP0084 | 2 | 217038562 | T | G | SNP0763 | 4 | 117541533 | T | C | SNP1442 | 13 | 24417995 | A | C |
SNP0085 | 2 | 217038578 | G | C | SNP0764 | 4 | 117541681 | G | A | SNP1443 | 13 | 24418069 | C | T |
SNP0086 | 2 | 217039070 | T | C | SNP0765 | 4 | 117541763 | T | C | SNP1444 | 13 | 24418517 | A | G |
SNP0087 | 2 | 217039110 | A | T | SNP0766 | 4 | 117541895 | C | T | SNP1445 | 13 | 24418585 | A | G |
SNP0088 | 2 | 217039138 | T | C | SNP0767 | 4 | 117543025 | T | C | SNP1446 | 13 | 24419103 | C | G |
SNP0089 | 2 | 217039407 | G | A | SNP0768 | 4 | 117543181 | G | A | SNP1447 | 13 | 24419170 | G | T |
SNP0090 | 2 | 217039530 | G | T | SNP0769 | 4 | 117543237 | C | T | SNP1448 | 13 | 24419688 | C | A |
SNP0091 | 2 | 217040002 | A | C | SNP0770 | 4 | 117543487 | C | T | SNP1449 | 13 | 24419882 | A | G |
SNP0092 | 2 | 217040125 | G | A | SNP0771 | 4 | 117543568 | G | C | SNP1450 | 13 | 24420047 | T | A |
SNP0093 | 2 | 217040153 | C | T | SNP0772 | 4 | 117544699 | G | T | SNP1451 | 13 | 24420357 | G | A |
SNP0094 | 2 | 217040558 | T | G | SNP0773 | 4 | 117545266 | T | C | SNP1452 | 13 | 24420611 | A | G |
SNP0095 | 2 | 217041035 | T | C | SNP0774 | 4 | 117545420 | A | C | SNP1453 | 13 | 24420622 | A | G |
SNP0096 | 2 | 217041477 | T | C | SNP0775 | 4 | 117545489 | C | T | SNP1454 | 13 | 24420841 | G | A |
SNP0097 | 2 | 217041986 | T | C | SNP0776 | 4 | 117545810 | C | T | SNP1455 | 13 | 24421432 | G | A |
SNP0098 | 2 | 217042981 | T | C | SNP0777 | 4 | 117546502 | C | G | SNP1456 | 13 | 24421550 | C | T |
SNP0099 | 2 | 217043959 | G | A | SNP0778 | 4 | 117546925 | C | T | SNP1457 | 13 | 24422351 | T | C |
SNP0100 | 2 | 217044049 | C | T | SNP0779 | 4 | 117547513 | A | G | SNP1458 | 13 | 24422931 | A | G |
SNP0101 | 2 | 217044422 | T | C | SNP0780 | 4 | 117547749 | C | T | SNP1459 | 13 | 24422989 | T | C |
SNP0102 | 2 | 217044926 | C | T | SNP0781 | 4 | 117548618 | G | A | SNP1460 | 13 | 24423064 | G | A |
SNP0103 | 2 | 217045538 | C | T | SNP0782 | 4 | 117548744 | T | C | SNP1461 | 13 | 24423105 | T | A |
SNP0104 | 2 | 217045818 | C | A | SNP0783 | 4 | 117548847 | T | A | SNP1462 | 13 | 24423379 | T | C |
SNP0105 | 2 | 217045835 | T | C | SNP0784 | 4 | 117550118 | C | T | SNP1463 | 13 | 24423701 | T | C |
SNP0106 | 2 | 217046233 | G | A | SNP0785 | 4 | 117550326 | T | C | SNP1464 | 13 | 24423926 | T | A |
SNP0107 | 2 | 217047554 | A | G | SNP0786 | 4 | 117552509 | C | A | SNP1465 | 13 | 24424140 | C | T |
SNP0108 | 2 | 217047803 | T | C | SNP0787 | 4 | 117552551 | G | A | SNP1466 | 15 | 41325648 | T | C |
SNP0109 | 2 | 217047846 | G | T | SNP0788 | 4 | 117552693 | C | G | SNP1467 | 15 | 41325813 | T | A |
SNP0110 | 2 | 217047935 | C | G | SNP0789 | 4 | 117552702 | C | A | SNP1468 | 15 | 41326450 | G | A |
SNP0111 | 2 | 217047942 | G | C | SNP0790 | 4 | 117552728 | C | T | SNP1469 | 15 | 41327686 | A | G |
SNP0112 | 2 | 217048094 | A | G | SNP0791 | 4 | 117553914 | G | A | SNP1470 | 15 | 41328767 | C | T |
SNP0113 | 2 | 217048135 | G | A | SNP0792 | 4 | 117554465 | G | A | SNP1471 | 15 | 41331309 | G | A |
SNP0114 | 2 | 217048308 | A | G | SNP0793 | 4 | 117555478 | T | G | SNP1472 | 15 | 41331316 | G | A |
SNP0115 | 2 | 217048480 | G | A | SNP0794 | 4 | 117555506 | C | G | SNP1473 | 15 | 41331588 | T | C |
SNP0116 | 2 | 217049501 | C | T | SNP0795 | 4 | 117556095 | T | C | SNP1474 | 15 | 41331811 | A | G |
SNP0117 | 2 | 217050687 | T | G | SNP0796 | 4 | 117556745 | A | G | SNP1475 | 15 | 41331839 | A | G |
SNP0118 | 2 | 217050704 | C | T | SNP0797 | 4 | 117557343 | C | G | SNP1476 | 15 | 41334505 | A | G |
SNP0119 | 2 | 217050988 | C | T | SNP0798 | 4 | 117557477 | G | A | SNP1477 | 15 | 41334533 | T | A |
SNP0120 | 2 | 217051035 | T | C | SNP0799 | 4 | 117558219 | G | A | SNP1478 | 15 | 41334637 | G | A |
SNP0121 | 2 | 217051139 | C | T | SNP0800 | 4 | 117558785 | C | T | SNP1479 | 15 | 41334969 | T | A |
SNP0122 | 2 | 217051186 | C | T | SNP0801 | 4 | 117558937 | G | A | SNP1480 | 15 | 41335362 | G | A |
SNP0123 | 2 | 217051423 | T | A | SNP0802 | 4 | 117558981 | C | T | SNP1481 | 15 | 41335579 | C | A |
SNP0124 | 2 | 217051486 | T | C | SNP0803 | 4 | 117559004 | T | C | SNP1482 | 15 | 41335707 | A | T |
SNP0125 | 2 | 217051638 | C | G | SNP0804 | 4 | 117559417 | A | C | SNP1483 | 15 | 41336162 | A | G |
SNP0126 | 2 | 217052243 | C | A | SNP0805 | 4 | 117559731 | A | C | SNP1484 | 15 | 41336226 | C | A |
SNP0127 | 2 | 217052958 | C | T | SNP0806 | 4 | 117559806 | G | A | SNP1485 | 15 | 41336631 | C | T |
SNP0128 | 2 | 217054097 | A | T | SNP0807 | 4 | 117559866 | C | T | SNP1486 | 15 | 41336812 | A | G |
SNP0129 | 2 | 217054334 | A | G | SNP0808 | 4 | 117562172 | C | G | SNP1487 | 15 | 41336955 | G | A |
SNP0130 | 2 | 217054514 | A | C | SNP0809 | 4 | 117562822 | G | A | SNP1488 | 15 | 41337023 | A | C |
SNP0131 | 2 | 217054572 | C | T | SNP0810 | 4 | 117564834 | T | C | SNP1489 | 15 | 41337196 | A | G |
SNP0132 | 2 | 217054963 | T | C | SNP0811 | 4 | 117566666 | C | G | SNP1490 | 15 | 41337228 | A | G |
SNP0133 | 2 | 217054969 | C | T | SNP0812 | 4 | 117567083 | G | A | SNP1491 | 15 | 41337675 | G | A |
SNP0134 | 2 | 217055016 | G | A | SNP0813 | 4 | 117569520 | T | C | SNP1492 | 15 | 41337899 | C | A |
SNP0135 | 2 | 217055323 | A | G | SNP0814 | 4 | 117569651 | A | G | SNP1493 | 15 | 41337953 | G | T |
SNP0136 | 2 | 217055334 | G | A | SNP0815 | 4 | 117570688 | C | T | SNP1494 | 15 | 41337989 | G | C |
SNP0137 | 2 | 217055569 | A | G | SNP0816 | 4 | 117570942 | C | T | SNP1495 | 15 | 41338087 | G | A |
SNP0138 | 2 | 217055582 | G | A | SNP0817 | 4 | 117571548 | A | G | SNP1496 | 15 | 41338522 | A | G |
SNP0139 | 2 | 217056087 | T | G | SNP0818 | 4 | 117571918 | T | G | SNP1497 | 15 | 41338610 | G | A |
SNP0140 | 2 | 217057623 | C | T | SNP0819 | 4 | 117572062 | G | C | SNP1498 | 15 | 41339260 | A | G |
SNP0141 | 2 | 217057670 | C | T | SNP0820 | 4 | 117572261 | G | A | SNP1499 | 15 | 41339443 | A | G |
SNP0142 | 2 | 217057917 | G | A | SNP0821 | 4 | 117572267 | C | T | SNP1500 | 15 | 41343013 | C | A |
SNP0143 | 2 | 217058006 | G | A | SNP0822 | 4 | 117573066 | C | T | SNP1501 | 15 | 41343111 | T | G |
SNP0144 | 2 | 217058127 | T | A | SNP0823 | 4 | 117574251 | G | A | SNP1502 | 15 | 41343235 | C | A |
SNP0145 | 2 | 217058203 | G | A | SNP0824 | 4 | 117574724 | T | A | SNP1503 | 15 | 41343376 | A | G |
SNP0146 | 2 | 217058226 | C | T | SNP0825 | 4 | 117575273 | T | C | SNP1504 | 15 | 41343512 | C | T |
SNP0147 | 2 | 217058521 | G | A | SNP0826 | 4 | 117575332 | G | T | SNP1505 | 15 | 41343610 | C | A |
SNP0148 | 2 | 217058556 | T | C | SNP0827 | 4 | 117575501 | T | C | SNP1506 | 15 | 41343693 | A | G |
SNP0149 | 2 | 217058786 | C | T | SNP0828 | 4 | 117575627 | T | C | SNP1507 | 15 | 41344279 | G | A |
SNP0150 | 2 | 217058867 | C | T | SNP0829 | 4 | 117575703 | A | G | SNP1508 | 15 | 41344497 | T | C |
SNP0151 | 2 | 217058986 | G | A | SNP0830 | 4 | 117575709 | T | C | SNP1509 | 15 | 41344743 | T | C |
SNP0152 | 2 | 217059397 | G | A | SNP0831 | 4 | 117576733 | C | T | SNP1510 | 15 | 41344902 | C | G |
SNP0153 | 2 | 217059688 | T | G | SNP0832 | 4 | 117577185 | T | C | SNP1511 | 15 | 41345846 | G | A |
SNP0154 | 2 | 217059923 | A | T | SNP0833 | 4 | 117577186 | A | T | SNP1512 | 15 | 41346230 | A | G |
SNP0155 | 2 | 217060086 | T | C | SNP0834 | 4 | 117578582 | C | A | SNP1513 | 15 | 41346367 | G | A |
SNP0156 | 2 | 217060252 | C | T | SNP0835 | 4 | 117580244 | A | G | SNP1514 | 15 | 41347522 | C | T |
SNP0157 | 2 | 217061067 | C | T | SNP0836 | 4 | 117580778 | G | A | SNP1515 | 15 | 41348067 | A | G |
SNP0158 | 2 | 217061696 | G | T | SNP0837 | 4 | 117580906 | G | A | SNP1516 | 15 | 41348247 | A | C |
SNP0159 | 2 | 217061831 | G | C | SNP0838 | 4 | 117583292 | C | T | SNP1517 | 15 | 41348344 | C | T |
SNP0160 | 2 | 217062060 | T | C | SNP0839 | 4 | 117583314 | C | T | SNP1518 | 15 | 41348908 | G | A |
SNP0161 | 2 | 217062612 | T | G | SNP0840 | 4 | 117583748 | C | T | SNP1519 | 15 | 41349144 | C | T |
SNP0162 | 2 | 217062769 | G | A | SNP0841 | 4 | 117584755 | C | T | SNP1520 | 15 | 41349548 | A | G |
SNP0163 | 2 | 217063284 | C | T | SNP0842 | 4 | 117584990 | C | G | SNP1521 | 15 | 41349910 | T | G |
SNP0164 | 2 | 217064292 | G | A | SNP0843 | 4 | 117585051 | G | A | SNP1522 | 15 | 41350097 | G | T |
SNP0165 | 2 | 217064996 | A | T | SNP0844 | 4 | 117586013 | G | A | SNP1523 | 15 | 41350299 | T | C |
SNP0166 | 2 | 217065698 | C | T | SNP0845 | 4 | 117586557 | G | A | SNP1524 | 15 | 41350392 | G | A |
SNP0167 | 2 | 217066956 | C | T | SNP0846 | 4 | 117586854 | G | C | SNP1525 | 15 | 41350687 | G | A |
SNP0168 | 2 | 217067723 | A | C | SNP0847 | 4 | 117586972 | G | A | SNP1526 | 15 | 41350987 | G | A |
SNP0169 | 2 | 217067738 | A | C | SNP0848 | 4 | 117587049 | G | A | SNP1527 | 15 | 41352407 | C | T |
SNP0170 | 2 | 217067813 | T | C | SNP0849 | 4 | 117587174 | A | C | SNP1528 | 15 | 41352439 | C | T |
SNP0171 | 2 | 217067835 | C | T | SNP0850 | 4 | 117587540 | G | A | SNP1529 | 15 | 41353000 | C | T |
SNP0172 | 2 | 217067967 | T | C | SNP0851 | 4 | 117587715 | G | C | SNP1530 | 15 | 41353318 | A | G |
SNP0173 | 2 | 217067975 | T | A | SNP0852 | 4 | 117588045 | T | C | SNP1531 | 15 | 41353501 | A | T |
SNP0174 | 2 | 217068289 | T | C | SNP0853 | 4 | 117588412 | T | G | SNP1532 | 15 | 41353639 | C | T |
SNP0175 | 2 | 217068703 | T | C | SNP0854 | 4 | 117588496 | T | C | SNP1533 | 15 | 41354446 | C | T |
SNP0176 | 2 | 217068777 | A | G | SNP0855 | 4 | 117588530 | G | A | SNP1534 | 15 | 41355740 | A | G |
SNP0177 | 2 | 217068945 | G | A | SNP0856 | 4 | 117588783 | G | A | SNP1535 | 15 | 41355744 | T | A |
SNP0178 | 2 | 217068975 | A | G | SNP0857 | 4 | 117589746 | A | G | SNP1536 | 15 | 41356214 | A | T |
SNP0179 | 2 | 217069999 | A | G | SNP0858 | 4 | 117589976 | G | A | SNP1537 | 15 | 41357040 | A | G |
SNP0180 | 2 | 217072815 | A | G | SNP0859 | 4 | 117589998 | A | C | SNP1538 | 15 | 41357080 | C | T |
SNP0181 | 2 | 217072924 | A | G | SNP0860 | 4 | 117592971 | T | A | SNP1539 | 15 | 41357252 | C | T |
SNP0182 | 2 | 217073221 | C | T | SNP0861 | 4 | 117593380 | G | C | SNP1540 | 15 | 41357261 | T | C |
SNP0183 | 2 | 217074721 | A | G | SNP0862 | 4 | 117593610 | G | A | SNP1541 | 15 | 41357444 | C | T |
SNP0184 | 2 | 217074752 | G | A | SNP0863 | 4 | 117593674 | C | G | SNP1542 | 15 | 41357455 | C | T |
SNP0185 | 2 | 217074798 | C | T | SNP0864 | 4 | 117593909 | G | A | SNP1543 | 15 | 41357493 | G | A |
SNP0186 | 2 | 217074804 | T | C | SNP0865 | 4 | 117594572 | A | G | SNP1544 | 15 | 41357608 | G | C |
SNP0187 | 2 | 96950143 | T | G | SNP0866 | 4 | 117594638 | C | T | SNP1545 | 15 | 41359091 | C | A |
SNP0188 | 2 | 96950411 | T | C | SNP0867 | 4 | 117594980 | T | C | SNP1546 | 15 | 41359231 | T | G |
SNP0189 | 2 | 96950723 | T | C | SNP0868 | 4 | 117595212 | G | T | SNP1547 | 15 | 41359232 | T | G |
SNP0190 | 2 | 96950749 | C | T | SNP0869 | 4 | 117595214 | A | T | SNP1548 | 15 | 41359874 | T | C |
SNP0191 | 2 | 96951045 | A | T | SNP0870 | 4 | 117595901 | A | G | SNP1549 | 15 | 41360130 | G | C |
SNP0192 | 2 | 96951778 | C | T | SNP0871 | 4 | 117596383 | C | T | SNP1550 | 15 | 41360507 | A | G |
SNP0193 | 2 | 96951787 | T | C | SNP0872 | 4 | 117596535 | T | C | SNP1551 | 15 | 41360554 | G | A |
SNP0194 | 2 | 96951867 | A | C | SNP0873 | 4 | 117596572 | G | C | SNP1552 | 15 | 41360663 | G | T |
SNP0195 | 2 | 96952556 | A | G | SNP0874 | 4 | 117596660 | C | T | SNP1553 | 15 | 41360776 | C | A |
SNP0196 | 2 | 96952671 | C | A | SNP0875 | 4 | 117596777 | T | C | SNP1554 | 15 | 41360806 | A | C |
SNP0197 | 2 | 96952678 | A | G | SNP0876 | 4 | 117596845 | T | G | SNP1555 | 15 | 41360909 | C | T |
SNP0198 | 2 | 96952683 | A | G | SNP0877 | 4 | 117597411 | C | T | SNP1556 | 15 | 41361032 | A | G |
SNP0199 | 2 | 96953369 | C | T | SNP0878 | 4 | 117597443 | C | T | SNP1557 | 15 | 41361358 | T | C |
SNP0200 | 2 | 96953370 | A | G | SNP0879 | 4 | 117597887 | C | G | SNP1558 | 15 | 41361519 | A | G |
SNP0201 | 2 | 96953652 | G | A | SNP0880 | 4 | 117598760 | G | T | SNP1559 | 15 | 41361606 | A | G |
SNP0202 | 2 | 96953738 | T | C | SNP0881 | 4 | 117598997 | T | C | SNP1560 | 15 | 41361915 | G | C |
SNP0203 | 2 | 96953743 | A | G | SNP0882 | 4 | 117599476 | A | G | SNP1561 | 15 | 41361964 | C | T |
SNP0204 | 2 | 96953748 | C | T | SNP0883 | 4 | 117599684 | A | C | SNP1562 | 15 | 41362087 | T | C |
SNP0205 | 2 | 96953834 | G | A | SNP0884 | 4 | 117599771 | T | G | SNP1563 | 15 | 41362159 | T | C |
SNP0206 | 2 | 96953916 | A | C | SNP0885 | 4 | 117599784 | C | T | SNP1564 | 15 | 41362477 | G | T |
SNP0207 | 2 | 96953927 | T | C | SNP0886 | 4 | 117599822 | A | G | SNP1565 | 15 | 41362658 | C | T |
SNP0208 | 2 | 96954085 | G | A | SNP0887 | 4 | 117600405 | A | G | SNP1566 | 15 | 41362711 | G | A |
SNP0209 | 2 | 96954132 | G | T | SNP0888 | 4 | 117600480 | T | C | SNP1567 | 15 | 41363268 | G | A |
SNP0210 | 2 | 96954262 | G | T | SNP0889 | 4 | 117600899 | A | G | SNP1568 | 15 | 41363416 | G | T |
SNP0211 | 2 | 96954290 | G | A | SNP0890 | 4 | 117601299 | C | G | SNP1569 | 15 | 41363449 | A | G |
SNP0212 | 2 | 96954306 | T | C | SNP0891 | 4 | 117603080 | A | C | SNP1570 | 15 | 41363757 | G | A |
SNP0213 | 2 | 96954327 | G | A | SNP0892 | 4 | 117603241 | C | G | SNP1571 | 15 | 41364520 | T | C |
SNP0214 | 2 | 96954447 | C | A | SNP0893 | 4 | 117603254 | A | C | SNP1572 | 15 | 41364528 | G | A |
SNP0215 | 2 | 96954586 | C | T | SNP0894 | 4 | 117603258 | G | A | SNP1573 | 15 | 41364545 | C | G |
SNP0216 | 2 | 96954781 | T | C | SNP0895 | 4 | 117603554 | T | C | SNP1574 | 15 | 41364677 | T | C |
SNP0217 | 2 | 96954802 | T | G | SNP0896 | 4 | 117603958 | G | A | SNP1575 | 15 | 41364824 | C | T |
SNP0218 | 2 | 96954862 | T | G | SNP0897 | 4 | 117604027 | T | C | SNP1576 | 15 | 41364881 | C | T |
SNP0219 | 2 | 96955334 | G | A | SNP0898 | 4 | 117604451 | T | C | SNP1577 | 15 | 41364951 | T | C |
SNP0220 | 2 | 96955462 | T | C | SNP0899 | 4 | 117604452 | G | A | SNP1578 | 15 | 41365086 | A | G |
SNP0221 | 2 | 96955765 | T | C | SNP0900 | 4 | 117605080 | A | C | SNP1579 | 15 | 41365770 | C | A |
SNP0222 | 2 | 96956174 | T | C | SNP0901 | 4 | 117605181 | G | A | SNP1580 | 15 | 41366133 | C | G |
SNP0223 | 2 | 96956284 | C | T | SNP0902 | 4 | 117605183 | T | C | SNP1581 | 15 | 41366386 | T | C |
SNP0224 | 2 | 96956388 | C | T | SNP0903 | 4 | 117605186 | A | G | SNP1582 | 15 | 41366532 | A | G |
SNP0225 | 2 | 96956463 | G | C | SNP0904 | 4 | 117605852 | T | C | SNP1583 | 15 | 41366604 | G | T |
SNP0226 | 2 | 96956480 | G | A | SNP0905 | 4 | 117605865 | T | C | SNP1584 | 15 | 41366925 | T | C |
SNP0227 | 2 | 96956640 | A | T | SNP0906 | 4 | 117606297 | C | A | SNP1585 | 15 | 41366936 | A | G |
SNP0228 | 2 | 96956710 | T | C | SNP0907 | 4 | 117606418 | G | A | SNP1586 | 15 | 41367509 | T | G |
SNP0229 | 2 | 96956873 | G | T | SNP0908 | 4 | 117606456 | T | C | SNP1587 | 15 | 41368223 | G | T |
SNP0230 | 2 | 96956901 | C | A | SNP0909 | 4 | 117606656 | T | C | SNP1588 | 15 | 41368380 | A | G |
SNP0231 | 2 | 96956970 | C | G | SNP0910 | 4 | 117606759 | C | T | SNP1589 | 15 | 41368552 | T | C |
SNP0232 | 2 | 96957206 | G | C | SNP0911 | 4 | 117606883 | A | G | SNP1590 | 15 | 41368642 | G | A |
SNP0233 | 2 | 96957329 | A | G | SNP0912 | 4 | 117606982 | C | T | SNP1591 | 15 | 41368660 | A | T |
SNP0234 | 2 | 96957728 | C | T | SNP0913 | 4 | 117606999 | C | T | SNP1592 | 15 | 41368822 | C | T |
SNP0235 | 2 | 96958027 | G | A | SNP0914 | 4 | 117607136 | T | C | SNP1593 | 15 | 41369189 | A | G |
SNP0236 | 2 | 96958060 | A | G | SNP0915 | 4 | 117607280 | T | C | SNP1594 | 15 | 41369235 | C | T |
SNP0237 | 2 | 96958063 | G | A | SNP0916 | 4 | 117607432 | A | G | SNP1595 | 15 | 41369322 | C | T |
SNP0238 | 2 | 96958195 | A | G | SNP0917 | 4 | 117607637 | G | A | SNP1596 | 15 | 41369531 | C | T |
SNP0239 | 2 | 96958331 | T | C | SNP0918 | 4 | 117607778 | T | C | SNP1597 | 15 | 41369651 | C | T |
SNP0240 | 2 | 96958357 | G | A | SNP0919 | 4 | 117607809 | A | G | SNP1598 | 15 | 41369741 | G | A |
SNP0241 | 2 | 96958419 | C | G | SNP0920 | 4 | 117608100 | C | T | SNP1599 | 15 | 41369754 | A | C |
SNP0242 | 2 | 96958824 | A | G | SNP0921 | 4 | 117608664 | T | C | SNP1600 | 15 | 41369950 | G | C |
SNP0243 | 2 | 96958846 | C | T | SNP0922 | 4 | 117609137 | T | G | SNP1601 | 15 | 41370502 | G | A |
SNP0244 | 2 | 96958866 | G | A | SNP0923 | 4 | 117609301 | C | T | SNP1602 | 15 | 41370534 | T | C |
SNP0245 | 2 | 96958924 | C | T | SNP0924 | 4 | 117609350 | C | T | SNP1603 | 15 | 41370628 | A | G |
SNP0246 | 2 | 96959018 | A | G | SNP0925 | 4 | 117609482 | A | G | SNP1604 | 15 | 41370816 | A | G |
SNP0247 | 2 | 96959085 | G | A | SNP0926 | 4 | 117609485 | C | T | SNP1605 | 15 | 41370883 | T | G |
SNP0248 | 2 | 96959373 | G | C | SNP0927 | 4 | 117609486 | G | A | SNP1606 | 15 | 41371151 | T | C |
SNP0249 | 2 | 96960250 | T | C | SNP0928 | 4 | 117609619 | T | A | SNP1607 | 15 | 41371165 | C | T |
SNP0250 | 2 | 96960522 | T | C | SNP0929 | 4 | 117609869 | C | T | SNP1608 | 15 | 41371267 | C | G |
SNP0251 | 2 | 96960533 | A | G | SNP0930 | 4 | 117610059 | T | C | SNP1609 | 15 | 41371336 | G | A |
SNP0252 | 2 | 96960858 | C | G | SNP0931 | 4 | 117610146 | A | G | SNP1610 | 15 | 41371645 | G | T |
SNP0253 | 2 | 96960941 | C | T | SNP0932 | 4 | 117610208 | C | T | SNP1611 | 15 | 41371690 | G | C |
SNP0254 | 2 | 96960967 | C | T | SNP0933 | 4 | 117610902 | C | T | SNP1612 | 15 | 41371727 | G | A |
SNP0255 | 2 | 96961083 | C | T | SNP0934 | 4 | 117610978 | A | C | SNP1613 | 15 | 41371799 | G | C |
SNP0256 | 2 | 96961410 | C | T | SNP0935 | 4 | 117611006 | G | A | SNP1614 | 15 | 41373072 | G | A |
SNP0257 | 2 | 96961481 | G | A | SNP0936 | 4 | 117611611 | A | C | SNP1615 | 15 | 41373324 | G | A |
SNP0258 | 2 | 96961519 | G | A | SNP0937 | 4 | 117611800 | G | A | SNP1616 | 15 | 41373553 | A | T |
SNP0259 | 2 | 96961554 | C | T | SNP0938 | 4 | 117612515 | T | C | SNP1617 | 15 | 41373693 | A | G |
SNP0260 | 2 | 96961699 | C | G | SNP0939 | 4 | 117612516 | T | C | SNP1618 | 15 | 41373707 | T | A |
SNP0261 | 2 | 96961719 | G | T | SNP0940 | 4 | 117612735 | A | G | SNP1619 | 15 | 41374164 | T | C |
SNP0262 | 2 | 96961792 | T | C | SNP0941 | 4 | 117613632 | T | G | SNP1620 | 15 | 41374475 | C | A |
SNP0263 | 2 | 96961870 | T | A | SNP0942 | 4 | 117613959 | T | C | SNP1621 | 19 | 43261804 | A | G |
SNP0264 | 2 | 96962111 | A | C | SNP0943 | 4 | 117614260 | A | T | SNP1622 | 19 | 43261878 | C | T |
SNP0265 | 2 | 96964226 | T | C | SNP0944 | 4 | 117614290 | G | A | SNP1623 | 19 | 43262709 | T | C |
SNP0266 | 2 | 96969706 | A | G | SNP0945 | 4 | 117614385 | C | T | SNP1624 | 19 | 43263239 | A | C |
SNP0267 | 2 | 96969756 | T | G | SNP0946 | 4 | 117614430 | G | C | SNP1625 | 19 | 43263324 | A | G |
SNP0268 | 2 | 96969764 | C | G | SNP0947 | 4 | 117614447 | C | G | SNP1626 | 19 | 43263384 | G | A |
SNP0269 | 2 | 96969769 | C | G | SNP0948 | 4 | 117614672 | C | T | SNP1627 | 19 | 43263443 | G | A |
SNP0270 | 2 | 96969824 | C | A | SNP0949 | 4 | 117614876 | A | G | SNP1628 | 19 | 43263715 | G | A |
SNP0271 | 2 | 96970238 | A | T | SNP0950 | 4 | 117615253 | G | A | SNP1629 | 19 | 43263759 | C | G |
SNP0272 | 2 | 96970288 | G | A | SNP0951 | 4 | 117615526 | G | C | SNP1630 | 19 | 43263775 | C | A |
SNP0273 | 2 | 96970337 | A | G | SNP0952 | 4 | 117615564 | G | A | SNP1631 | 19 | 43263910 | C | T |
SNP0274 | 2 | 96970353 | C | T | SNP0953 | 4 | 117616198 | A | G | SNP1632 | 19 | 43264003 | T | C |
SNP0275 | 2 | 96970558 | A | G | SNP0954 | 4 | 117616361 | T | G | SNP1633 | 19 | 43264004 | G | A |
SNP0276 | 2 | 96970655 | C | T | SNP0955 | 4 | 117616979 | G | C | SNP1634 | 19 | 43264079 | T | G |
SNP0277 | 2 | 96970693 | C | T | SNP0956 | 4 | 117617088 | C | T | SNP1635 | 19 | 43264153 | A | G |
SNP0278 | 2 | 96970845 | C | T | SNP0957 | 4 | 117618337 | G | A | SNP1636 | 19 | 43264341 | A | T |
SNP0279 | 2 | 96971072 | C | G | SNP0958 | 4 | 117618887 | A | G | SNP1637 | 19 | 43264394 | T | C |
SNP0280 | 2 | 96971285 | G | C | SNP0959 | 4 | 117619293 | G | T | SNP1638 | 19 | 43264475 | A | T |
SNP0281 | 2 | 96971297 | C | T | SNP0960 | 4 | 117619772 | C | A | SNP1639 | 19 | 43265354 | T | C |
SNP0282 | 2 | 96971325 | T | G | SNP0961 | 4 | 117620409 | G | A | SNP1640 | 19 | 43265825 | G | A |
SNP0283 | 2 | 96971736 | C | T | SNP0962 | 4 | 117620545 | A | G | SNP1641 | 19 | 43265956 | A | T |
SNP0284 | 2 | 96971984 | A | G | SNP0963 | 4 | 117620954 | G | A | SNP1642 | 19 | 43266085 | G | A |
SNP0285 | 2 | 96972227 | G | A | SNP0964 | 4 | 117621168 | G | A | SNP1643 | 19 | 43267016 | C | T |
SNP0286 | 2 | 96972386 | G | A | SNP0965 | 4 | 117621503 | T | C | SNP1644 | 19 | 43267096 | T | C |
SNP0287 | 2 | 96972528 | T | C | SNP0966 | 4 | 117621526 | T | C | SNP1645 | 19 | 43267819 | A | G |
SNP0288 | 2 | 96972839 | T | C | SNP0967 | 4 | 117621666 | C | T | SNP1646 | 19 | 43267866 | G | A |
SNP0289 | 2 | 96972888 | A | G | SNP0968 | 4 | 117622043 | T | C | SNP1647 | 19 | 43268108 | T | C |
SNP0290 | 2 | 96972983 | T | C | SNP0969 | 4 | 117623255 | C | T | SNP1648 | 19 | 43268610 | C | G |
SNP0291 | 2 | 96973049 | A | T | SNP0970 | 4 | 117624046 | C | T | SNP1649 | 19 | 43269501 | C | G |
SNP0292 | 2 | 96973134 | G | A | SNP0971 | 4 | 117624964 | A | G | SNP1650 | 19 | 43269549 | C | T |
SNP0293 | 2 | 96973963 | G | A | SNP0972 | 4 | 117626741 | T | C | SNP1651 | 19 | 43269586 | G | A |
SNP0294 | 2 | 96974032 | C | T | SNP0973 | 4 | 117627208 | C | T | SNP1652 | 19 | 43269965 | G | A |
SNP0295 | 2 | 96974250 | A | C | SNP0974 | 4 | 117627518 | G | A | SNP1653 | 19 | 43270126 | G | A |
SNP0296 | 2 | 96974567 | T | C | SNP0975 | 4 | 117627705 | C | T | SNP1654 | 19 | 43270293 | C | T |
SNP0297 | 2 | 96974764 | C | T | SNP0976 | 4 | 117628220 | G | C | SNP1655 | 19 | 43270401 | C | A |
SNP0298 | 2 | 96974783 | G | A | SNP0977 | 4 | 117628750 | G | A | SNP1656 | 19 | 43270791 | G | C |
SNP0299 | 2 | 96975254 | G | C | SNP0978 | 4 | 117629141 | C | A | SNP1657 | 19 | 43270935 | G | C |
SNP0300 | 2 | 96975455 | C | A | SNP0979 | 4 | 117629155 | T | C | SNP1658 | 19 | 43273795 | G | A |
SNP0301 | 2 | 96975649 | G | A | SNP0980 | 4 | 117629221 | G | A | SNP1659 | 19 | 43274540 | C | G |
SNP0302 | 2 | 96975668 | T | C | SNP0981 | 4 | 117630100 | T | C | SNP1660 | 19 | 43274934 | T | C |
SNP0303 | 2 | 96975985 | C | T | SNP0982 | 4 | 117630591 | T | C | SNP1661 | 19 | 43276110 | G | A |
SNP0304 | 2 | 96976473 | C | T | SNP0983 | 4 | 117633124 | C | T | SNP1662 | 19 | 43276164 | T | A |
SNP0305 | 2 | 96976848 | A | G | SNP0984 | 4 | 117633146 | A | C | SNP1663 | 19 | 43276246 | A | G |
SNP0306 | 2 | 96977005 | T | C | SNP0985 | 4 | 117633151 | C | T | SNP1664 | 19 | 43276261 | T | C |
SNP0307 | 2 | 96978240 | T | G | SNP0986 | 4 | 117633931 | C | T | SNP1665 | 19 | 43276466 | C | T |
SNP0308 | 2 | 96979672 | T | C | SNP0987 | 4 | 117634883 | T | C | SNP1666 | 19 | 43276741 | C | T |
SNP0309 | 2 | 96979966 | C | T | SNP0988 | 4 | 117634901 | A | G | SNP1667 | 19 | 43277322 | C | T |
SNP0310 | 2 | 96979969 | C | T | SNP0989 | 4 | 117636042 | C | T | SNP1668 | 19 | 43277325 | A | T |
SNP0311 | 2 | 96979974 | C | T | SNP0990 | 4 | 117636508 | C | T | SNP1669 | 19 | 43277391 | G | A |
SNP0312 | 2 | 96980145 | T | C | SNP0991 | 4 | 117637035 | G | C | SNP1670 | 19 | 43277597 | G | A |
SNP0313 | 2 | 96980169 | C | T | SNP0992 | 4 | 117637361 | G | A | SNP1671 | 19 | 43277821 | G | A |
SNP0314 | 2 | 96980261 | G | C | SNP0993 | 4 | 117637949 | A | G | SNP1672 | 19 | 43278611 | T | A |
SNP0315 | 2 | 96980294 | T | C | SNP0994 | 4 | 117638012 | C | T | SNP1673 | 19 | 43278638 | C | A |
SNP0316 | 2 | 96980311 | A | G | SNP0995 | 4 | 117638837 | T | C | SNP1674 | 19 | 43278734 | T | C |
SNP0317 | 2 | 96980500 | G | A | SNP0996 | 4 | 117639226 | G | A | SNP1675 | 19 | 43278772 | C | A |
SNP0318 | 2 | 96980546 | G | C | SNP0997 | 4 | 117640208 | C | T | SNP1676 | 19 | 43279009 | A | T |
SNP0319 | 2 | 96980561 | G | A | SNP0998 | 4 | 117640223 | T | C | SNP1677 | 19 | 43279711 | T | C |
SNP0320 | 2 | 96980726 | G | A | SNP0999 | 4 | 117640392 | G | A | SNP1678 | 19 | 43279779 | G | C |
SNP0321 | 2 | 96981265 | A | G | SNP1000 | 4 | 117640462 | C | T | SNP1679 | 19 | 43279925 | C | T |
SNP0322 | 2 | 96981697 | G | A | SNP1001 | 4 | 117641530 | C | A | SNP1680 | 19 | 43280584 | T | C |
SNP0323 | 2 | 96981774 | A | C | SNP1002 | 4 | 117641632 | A | G | SNP1681 | 19 | 43281886 | A | G |
SNP0324 | 2 | 96981997 | A | G | SNP1003 | 4 | 117641821 | A | C | SNP1682 | 19 | 43282421 | A | G |
SNP0325 | 2 | 96982010 | A | G | SNP1004 | 4 | 117641967 | A | T | SNP1683 | 19 | 43282794 | C | T |
SNP0326 | 2 | 96982077 | G | T | SNP1005 | 4 | 117642216 | G | A | SNP1684 | 19 | 43284862 | T | G |
SNP0327 | 2 | 96982193 | C | T | SNP1006 | 4 | 117642217 | T | G | SNP1685 | 19 | 43285333 | T | A |
SNP0328 | 2 | 96982275 | T | C | SNP1007 | 4 | 117642441 | G | C | SNP1686 | 19 | 43285386 | T | A |
SNP0329 | 2 | 96982320 | G | A | SNP1008 | 4 | 117643107 | A | G | SNP1687 | 19 | 43286240 | C | T |
SNP0330 | 2 | 96982399 | A | C | SNP1009 | 4 | 117643189 | A | G | SNP1688 | 19 | 43287133 | C | T |
SNP0331 | 2 | 96982731 | C | T | SNP1010 | 4 | 117643874 | C | T | SNP1689 | 19 | 43287548 | A | C |
SNP0332 | 2 | 96983131 | T | C | SNP1011 | 4 | 117644468 | T | C | SNP1690 | 19 | 43287694 | G | C |
SNP0333 | 2 | 96983507 | T | C | SNP1012 | 4 | 117644577 | A | G | SNP1691 | 19 | 43287790 | T | C |
SNP0334 | 2 | 96983584 | A | T | SNP1013 | 4 | 117644578 | C | T | SNP1692 | 19 | 43288095 | A | C |
SNP0335 | 2 | 96983632 | A | C | SNP1014 | 4 | 117644612 | A | G | SNP1693 | 19 | 43288202 | T | C |
SNP0336 | 2 | 96983733 | T | C | SNP1015 | 4 | 117644639 | T | G | SNP1694 | 19 | 43288711 | G | C |
SNP0337 | 2 | 96983894 | T | A | SNP1016 | 4 | 117644999 | G | C | SNP1695 | 19 | 43288738 | C | T |
SNP0338 | 2 | 96984220 | T | G | SNP1017 | 4 | 117645038 | C | A | SNP1696 | 19 | 43288877 | A | G |
SNP0339 | 2 | 96984934 | G | A | SNP1018 | 4 | 117645657 | A | G | SNP1697 | 19 | 43288904 | C | G |
SNP0340 | 2 | 96985258 | G | A | SNP1019 | 4 | 117645763 | G | A | SNP1698 | 19 | 43288973 | T | C |
SNP0341 | 2 | 96985622 | A | G | SNP1020 | 4 | 117646013 | T | C | SNP1699 | 19 | 43289119 | A | G |
SNP0342 | 2 | 96985625 | A | G | SNP1021 | 4 | 117646463 | T | A | SNP1700 | 19 | 43291662 | G | A |
SNP0343 | 2 | 96985948 | G | A | SNP1022 | 4 | 117646534 | T | C | SNP1701 | 19 | 43292403 | G | A |
SNP0344 | 2 | 96985975 | G | A | SNP1023 | 4 | 117646563 | A | G | SNP1702 | 19 | 43293433 | C | G |
SNP0345 | 2 | 96986016 | T | G | SNP1024 | 4 | 117646602 | T | G | SNP1703 | 19 | 43293505 | C | A |
SNP0346 | 2 | 96986219 | T | C | SNP1025 | 4 | 117647672 | G | A | SNP1704 | 19 | 43293903 | C | T |
SNP0347 | 2 | 96986425 | A | G | SNP1026 | 4 | 117648965 | G | A | SNP1705 | 19 | 43293931 | A | G |
SNP0348 | 2 | 96986720 | G | A | SNP1027 | 4 | 117649166 | T | C | SNP1706 | 19 | 43294206 | C | T |
SNP0349 | 2 | 96986807 | C | T | SNP1028 | 4 | 117649687 | A | G | SNP1707 | 19 | 43294434 | A | G |
SNP0350 | 2 | 96987003 | T | C | SNP1029 | 4 | 117649694 | C | T | SNP1708 | 19 | 43295705 | C | G |
SNP0351 | 2 | 96987162 | G | A | SNP1030 | 4 | 117649826 | C | T | SNP1709 | 19 | 43295904 | G | A |
SNP0352 | 2 | 96987223 | T | C | SNP1031 | 10 | 85877355 | A | G | SNP1710 | 19 | 43295918 | C | T |
SNP0353 | 2 | 96987434 | C | A | SNP1032 | 10 | 85878097 | T | G | SNP1711 | 19 | 43296065 | C | A |
SNP0354 | 2 | 96987711 | A | C | SNP1033 | 10 | 85878533 | A | G | SNP1712 | 19 | 43296225 | T | C |
SNP0355 | 2 | 96987929 | T | C | SNP1034 | 10 | 85879303 | C | T | SNP1713 | 19 | 43296430 | C | T |
SNP0356 | 2 | 96987990 | C | T | SNP1035 | 10 | 85879351 | C | G | SNP1714 | 19 | 43296431 | G | A |
SNP0357 | 2 | 96988220 | A | G | SNP1036 | 10 | 85879559 | C | G | SNP1715 | 19 | 43296472 | T | C |
SNP0358 | 2 | 96988822 | A | C | SNP1037 | 10 | 85879837 | G | C | SNP1716 | 19 | 43296539 | T | G |
SNP0359 | 2 | 96989516 | A | C | SNP1038 | 10 | 85879932 | A | G | SNP1717 | 19 | 43296769 | T | C |
SNP0360 | 2 | 96989562 | C | T | SNP1039 | 10 | 85879949 | A | G | SNP1718 | 19 | 43296800 | C | T |
SNP0361 | 2 | 96989644 | C | T | SNP1040 | 10 | 85880280 | G | A | SNP1719 | 19 | 43296918 | A | G |
SNP0362 | 2 | 96990150 | A | T | SNP1041 | 10 | 85880379 | C | G | SNP1720 | 19 | 43296921 | G | A |
SNP0363 | 2 | 96990357 | T | C | SNP1042 | 10 | 85880380 | A | G | SNP1721 | 19 | 43296982 | G | C |
SNP0364 | 2 | 96990364 | C | T | SNP1043 | 10 | 85880448 | T | C | SNP1722 | 19 | 43297223 | A | G |
SNP0365 | 2 | 96990402 | A | G | SNP1044 | 10 | 85880525 | G | A | SNP1723 | 19 | 43297274 | T | A |
SNP0366 | 2 | 96991294 | C | T | SNP1045 | 10 | 85880670 | T | C | SNP1724 | 19 | 43297276 | G | A |
SNP0367 | 2 | 96991643 | C | T | SNP1046 | 10 | 85880678 | T | C | SNP1725 | 19 | 43297349 | C | G |
SNP0368 | 2 | 96991752 | A | G | SNP1047 | 10 | 85880724 | C | T | SNP1726 | 19 | 43299034 | T | C |
SNP0369 | 2 | 96991843 | T | G | SNP1048 | 10 | 85880734 | G | A | SNP1727 | 19 | 43299830 | T | C |
SNP0370 | 2 | 96991909 | C | G | SNP1049 | 10 | 85880805 | C | A | SNP1728 | 19 | 43300193 | A | G |
SNP0371 | 2 | 96992107 | A | G | SNP1050 | 10 | 85880840 | C | A | SNP1729 | 19 | 43300247 | T | C |
SNP0372 | 2 | 96992691 | T | G | SNP1051 | 10 | 85881139 | A | G | SNP1730 | 19 | 43300478 | C | A |
SNP0373 | 2 | 96993458 | T | A | SNP1052 | 10 | 85881426 | C | T | SNP1731 | 19 | 43300481 | C | T |
SNP0374 | 2 | 96993622 | T | C | SNP1053 | 10 | 85881441 | T | C | SNP1732 | 19 | 43300578 | G | A |
SNP0375 | 2 | 96994239 | C | T | SNP1054 | 10 | 85881547 | C | T | SNP1733 | 19 | 43300680 | A | C |
SNP0376 | 2 | 96994586 | C | T | SNP1055 | 10 | 85881808 | C | T | SNP1734 | 19 | 43300843 | C | T |
SNP0377 | 2 | 96995021 | A | C | SNP1056 | 10 | 85881859 | C | T | SNP1735 | 19 | 43300864 | A | G |
SNP0378 | 2 | 96995929 | C | T | SNP1057 | 10 | 85882523 | G | A | SNP1736 | 19 | 43301505 | T | G |
SNP0379 | 2 | 96997059 | C | A | SNP1058 | 10 | 85882535 | A | G | SNP1737 | 19 | 43301768 | T | C |
SNP0380 | 2 | 96997446 | G | A | SNP1059 | 10 | 85882901 | T | C | SNP1738 | 19 | 43301862 | C | T |
SNP0381 | 2 | 96999052 | T | C | SNP1060 | 10 | 85883624 | A | G | SNP1739 | 19 | 43301878 | C | A |
SNP0382 | 2 | 96999887 | T | C | SNP1061 | 10 | 85884793 | T | C | SNP1740 | 19 | 43302042 | T | C |
SNP0383 | 3 | 112400166 | A | G | SNP1062 | 10 | 85884885 | G | A | SNP1741 | 19 | 43302383 | G | A |
SNP0384 | 3 | 112400553 | A | G | SNP1063 | 10 | 85885176 | C | G | SNP1742 | 19 | 43302805 | A | C |
SNP0385 | 3 | 112400965 | C | T | SNP1064 | 10 | 85886617 | T | C | SNP1743 | 19 | 43302847 | A | C |
SNP0386 | 3 | 112401037 | G | A | SNP1065 | 10 | 85886699 | C | G | SNP1744 | 19 | 43303247 | T | C |
SNP0387 | 3 | 112401134 | T | G | SNP1066 | 10 | 85886812 | G | A | SNP1745 | 19 | 43303723 | G | A |
SNP0388 | 3 | 112401169 | C | T | SNP1067 | 10 | 85889163 | C | T | SNP1746 | 19 | 43304123 | T | C |
SNP0389 | 3 | 112401282 | G | A | SNP1068 | 10 | 85889259 | T | G | SNP1747 | 19 | 43304171 | A | G |
SNP0390 | 3 | 112401650 | G | A | SNP1069 | 10 | 85890190 | C | T | SNP1748 | 19 | 43304313 | C | T |
SNP0391 | 3 | 112401815 | A | G | SNP1070 | 10 | 85890293 | C | T | SNP1749 | 19 | 43304314 | G | A |
SNP0392 | 3 | 112401856 | A | C | SNP1071 | 10 | 85890376 | A | G | SNP1750 | 19 | 43304492 | C | T |
SNP0393 | 3 | 112402053 | G | C | SNP1072 | 10 | 85890555 | C | T | SNP1751 | 19 | 43304761 | G | T |
SNP0394 | 3 | 112402129 | A | G | SNP1073 | 10 | 85890639 | A | G | SNP1752 | 19 | 43306704 | C | T |
SNP0395 | 3 | 112402790 | C | T | SNP1074 | 10 | 85891779 | C | T | SNP1753 | 19 | 43306737 | A | G |
SNP0396 | 3 | 112403397 | G | A | SNP1075 | 10 | 85891780 | A | G | SNP1754 | 19 | 43306822 | C | T |
SNP0397 | 3 | 112403581 | G | A | SNP1076 | 10 | 85892066 | G | C | SNP1755 | 19 | 43306860 | C | T |
SNP0398 | 3 | 112403894 | C | T | SNP1077 | 10 | 85892368 | T | C | SNP1756 | 19 | 43307463 | A | G |
SNP0399 | 3 | 112405906 | G | A | SNP1078 | 10 | 85892674 | G | A | SNP1757 | 19 | 43307548 | C | T |
SNP0400 | 3 | 112406943 | T | C | SNP1079 | 10 | 85892810 | A | G | SNP1758 | 19 | 43307637 | C | A |
SNP0401 | 3 | 112406962 | G | A | SNP1080 | 10 | 85893012 | G | A | SNP1759 | 19 | 43307937 | C | T |
SNP0402 | 3 | 112407074 | C | A | SNP1081 | 10 | 85893331 | A | G | SNP1760 | 19 | 43308430 | C | T |
SNP0403 | 3 | 112407341 | T | A | SNP1082 | 10 | 85893356 | G | T | SNP1761 | 19 | 43308434 | G | A |
SNP0404 | 3 | 112407429 | T | G | SNP1083 | 10 | 85893662 | G | A | SNP1762 | 19 | 43308603 | C | T |
SNP0405 | 3 | 112407436 | G | A | SNP1084 | 10 | 85893738 | G | A | SNP1763 | 19 | 43308678 | C | G |
SNP0406 | 3 | 112407464 | A | G | SNP1085 | 10 | 85893740 | T | C | SNP1764 | 19 | 43308886 | T | C |
SNP0407 | 3 | 112407700 | C | T | SNP1086 | 10 | 85894421 | G | A | SNP1765 | 19 | 43308901 | A | G |
SNP0408 | 3 | 112407736 | T | C | SNP1087 | 10 | 85894998 | C | G | SNP1766 | 19 | 43308945 | A | G |
SNP0409 | 3 | 112407758 | G | A | SNP1088 | 10 | 85896081 | T | C | SNP1767 | 19 | 43309064 | T | C |
SNP0410 | 3 | 112408324 | G | A | SNP1089 | 10 | 85896093 | T | C | SNP1768 | 19 | 43309083 | T | C |
SNP0411 | 3 | 112408899 | C | A | SNP1090 | 10 | 85896932 | A | G | SNP1769 | 19 | 43309289 | T | C |
SNP0412 | 3 | 112409880 | A | G | SNP1091 | 10 | 85897284 | G | C | SNP1770 | 19 | 43309653 | G | T |
SNP0413 | 3 | 112416706 | A | G | SNP1092 | 10 | 85897740 | C | T | SNP1771 | 19 | 43312055 | A | G |
SNP0414 | 3 | 112421594 | G | A | SNP1093 | 10 | 85897787 | C | T | SNP1772 | 19 | 43312185 | T | A |
SNP0415 | 3 | 112431348 | T | C | SNP1094 | 10 | 85899651 | C | T | SNP1773 | 19 | 43314845 | C | T |
SNP0416 | 3 | 112431514 | G | A | SNP1095 | 10 | 85901644 | G | A | SNP1774 | 19 | 43319126 | T | C |
SNP0417 | 3 | 112431662 | T | C | SNP1096 | 10 | 85902894 | C | T | SNP1775 | 19 | 43319696 | A | C |
SNP0418 | 3 | 112432392 | C | T | SNP1097 | 10 | 85903780 | C | G | SNP1776 | 19 | 43321298 | T | G |
SNP0419 | 3 | 112432944 | G | A | SNP1098 | 10 | 85903782 | G | T | SNP1777 | 19 | 43323805 | T | A |
SNP0420 | 3 | 112433040 | T | C | SNP1099 | 10 | 85904190 | C | T | SNP1778 | 19 | 43324037 | C | G |
SNP0421 | 3 | 112433565 | T | C | SNP1100 | 10 | 85904201 | C | A | SNP1779 | 19 | 43324423 | C | T |
SNP0422 | 3 | 112433641 | C | T | SNP1101 | 10 | 85904884 | T | C | SNP1780 | 19 | 43324688 | T | C |
SNP0423 | 3 | 112433700 | A | G | SNP1102 | 10 | 85905036 | C | T | SNP1781 | 23 | 61275192 | A | T |
SNP0424 | 3 | 112433849 | C | T | SNP1103 | 10 | 85907660 | A | G | SNP1782 | 23 | 61275670 | G | T |
SNP0425 | 3 | 112434307 | C | T | SNP1104 | 10 | 85907746 | A | G | SNP1783 | 23 | 61275708 | A | G |
SNP0426 | 3 | 112434508 | T | C | SNP1105 | 10 | 85908754 | G | A | SNP1784 | 23 | 61275839 | G | A |
SNP0427 | 3 | 112434602 | T | G | SNP1106 | 10 | 85910036 | G | A | SNP1785 | 23 | 61276705 | G | A |
SNP0428 | 3 | 112434612 | G | A | SNP1107 | 10 | 85910196 | T | C | SNP1786 | 23 | 61278894 | A | G |
SNP0429 | 3 | 112434617 | A | C | SNP1108 | 10 | 85910806 | C | T | SNP1787 | 23 | 61278916 | T | C |
SNP0430 | 3 | 112434948 | A | G | SNP1109 | 10 | 85912040 | G | A | SNP1788 | 23 | 61278976 | G | A |
SNP0431 | 3 | 112434996 | T | C | SNP1110 | 10 | 85913063 | C | T | SNP1789 | 23 | 61279124 | C | T |
SNP0432 | 3 | 112435018 | T | C | SNP1111 | 10 | 85913249 | T | C | SNP1790 | 23 | 61281011 | T | C |
SNP0433 | 3 | 112435225 | C | A | SNP1112 | 10 | 85913334 | A | G | SNP1791 | 23 | 61281452 | C | T |
SNP0434 | 3 | 112435362 | G | A | SNP1113 | 10 | 85913450 | C | G | SNP1792 | 23 | 61281669 | A | G |
SNP0435 | 3 | 112435446 | G | A | SNP1114 | 10 | 85914181 | G | A | SNP1793 | 23 | 61283011 | C | T |
SNP0436 | 3 | 112436202 | T | C | SNP1115 | 10 | 85914472 | C | T | SNP1794 | 23 | 61283519 | T | C |
SNP0437 | 3 | 112436274 | A | G | SNP1116 | 10 | 85915110 | A | G | SNP1795 | 23 | 61283787 | C | T |
SNP0438 | 3 | 112436844 | A | G | SNP1117 | 10 | 85915302 | C | G | SNP1796 | 23 | 61284890 | G | A |
SNP0439 | 3 | 112437048 | A | G | SNP1118 | 10 | 85915339 | C | T | SNP1797 | 23 | 61285102 | G | A |
SNP0440 | 3 | 112437068 | A | G | SNP1119 | 10 | 85915490 | T | C | SNP1798 | 23 | 61285310 | A | G |
SNP0441 | 3 | 112437683 | G | T | SNP1120 | 10 | 85915751 | C | T | SNP1799 | 23 | 61285365 | C | T |
SNP0442 | 3 | 112437920 | T | C | SNP1121 | 10 | 85916373 | C | T | SNP1800 | 23 | 61287475 | C | T |
SNP0443 | 3 | 112437929 | A | G | SNP1122 | 10 | 85916536 | T | C | SNP1801 | 23 | 61287571 | C | T |
SNP0444 | 3 | 112438078 | G | T | SNP1123 | 10 | 85916656 | C | T | SNP1802 | 23 | 61288294 | T | C |
SNP0445 | 3 | 112438170 | G | A | SNP1124 | 10 | 85916770 | C | G | SNP1803 | 23 | 61292250 | A | G |
SNP0446 | 3 | 112438349 | C | A | SNP1125 | 10 | 85917154 | G | A | SNP1804 | 23 | 61293817 | C | T |
SNP0447 | 3 | 112438378 | T | G | SNP1126 | 10 | 85917482 | T | C | SNP1805 | 23 | 61293974 | G | A |
SNP0448 | 3 | 112438427 | C | T | SNP1127 | 10 | 85918389 | C | T | SNP1806 | 23 | 61294492 | C | T |
SNP0449 | 3 | 112438475 | A | G | SNP1128 | 10 | 85918492 | C | G | SNP1807 | 23 | 61294547 | G | A |
SNP0450 | 3 | 112438709 | G | A | SNP1129 | 10 | 85918761 | T | C | SNP1808 | 23 | 61294621 | T | C |
SNP0451 | 3 | 112439248 | C | T | SNP1130 | 10 | 85919106 | T | C | SNP1809 | 23 | 61295159 | T | G |
SNP0452 | 3 | 112439739 | T | C | SNP1131 | 10 | 85919200 | C | T | SNP1810 | 23 | 61295561 | T | C |
SNP0453 | 3 | 112440985 | T | C | SNP1132 | 10 | 85919204 | T | G | SNP1811 | 23 | 61296481 | G | C |
SNP0454 | 3 | 112441183 | G | A | SNP1133 | 10 | 85919405 | A | G | SNP1812 | 23 | 61300052 | A | G |
SNP0455 | 3 | 112441379 | T | C | SNP1134 | 10 | 85919658 | T | C | SNP1813 | 23 | 61300125 | T | A |
SNP0456 | 3 | 112441991 | A | C | SNP1135 | 10 | 85919723 | T | C | SNP1814 | 23 | 61300164 | G | A |
SNP0457 | 3 | 112442154 | T | C | SNP1136 | 10 | 85920143 | C | T | SNP1815 | 23 | 61301064 | C | T |
SNP0458 | 3 | 112442695 | G | A | SNP1137 | 10 | 85920163 | G | C | SNP1816 | 23 | 61302117 | A | G |
SNP0459 | 3 | 112443048 | G | A | SNP1138 | 10 | 85920321 | A | C | SNP1817 | 23 | 61302146 | T | C |
SNP0460 | 3 | 112443431 | C | T | SNP1139 | 10 | 85921512 | A | C | SNP1818 | 23 | 61302147 | G | C |
SNP0461 | 3 | 112444570 | G | C | SNP1140 | 10 | 85921620 | T | C | SNP1819 | 23 | 61302249 | A | G |
SNP0462 | 3 | 112446293 | C | T | SNP1141 | 10 | 85921664 | G | A | SNP1820 | 23 | 61302498 | G | A |
SNP0463 | 3 | 112446600 | G | A | SNP1142 | 10 | 85921755 | C | T | SNP1821 | 23 | 61302790 | C | T |
SNP0464 | 3 | 112446665 | G | C | SNP1143 | 10 | 85922220 | G | T | SNP1822 | 23 | 61302830 | T | C |
SNP0465 | 3 | 112446681 | T | G | SNP1144 | 10 | 85922646 | G | A | SNP1823 | 23 | 61302837 | A | G |
SNP0466 | 3 | 112446716 | A | G | SNP1145 | 10 | 85924056 | A | G | SNP1824 | 23 | 61302984 | A | G |
SNP0467 | 3 | 112446925 | T | G | SNP1146 | 10 | 85925244 | A | C | SNP1825 | 23 | 61302991 | G | A |
SNP0468 | 3 | 112448131 | T | C | SNP1147 | 10 | 85925416 | A | G | SNP1826 | 23 | 61303186 | T | C |
SNP0469 | 3 | 112448768 | C | T | SNP1148 | 10 | 85925506 | C | G | SNP1827 | 23 | 61303187 | G | A |
SNP0470 | 3 | 112448884 | G | T | SNP1149 | 10 | 85925557 | C | T | SNP1828 | 23 | 61303402 | C | T |
SNP0471 | 3 | 112449510 | G | T | SNP1150 | 10 | 85925788 | T | C | SNP1829 | 23 | 61303608 | C | T |
SNP0472 | 3 | 112450042 | T | C | SNP1151 | 10 | 85925830 | T | C | SNP1830 | 23 | 61303977 | G | A |
SNP0473 | 3 | 112450061 | T | C | SNP1152 | 10 | 85926296 | C | T | SNP1831 | 23 | 61304097 | G | A |
SNP0474 | 3 | 112450315 | C | A | SNP1153 | 10 | 85926328 | C | T | SNP1832 | 23 | 61304320 | C | T |
SNP0475 | 3 | 112450804 | A | T | SNP1154 | 10 | 85926341 | T | G | SNP1833 | 23 | 61304430 | A | G |
SNP0476 | 3 | 112451304 | A | G | SNP1155 | 10 | 85926346 | G | A | SNP1834 | 23 | 61306239 | C | G |
SNP0477 | 3 | 112452309 | G | A | SNP1156 | 10 | 85926896 | A | C | SNP1835 | 23 | 61306666 | G | A |
SNP0478 | 3 | 112452495 | G | A | SNP1157 | 10 | 85927277 | C | T | SNP1836 | 23 | 61307157 | T | C |
SNP0479 | 3 | 112452754 | G | A | SNP1158 | 10 | 85927321 | G | C | SNP1837 | 23 | 61307158 | G | A |
SNP0480 | 3 | 112452798 | A | C | SNP1159 | 10 | 85927456 | A | G | SNP1838 | 23 | 61307711 | C | T |
SNP0481 | 3 | 112452832 | A | G | SNP1160 | 10 | 85927566 | A | C | SNP1839 | 23 | 61308053 | T | C |
SNP0482 | 3 | 112453104 | C | A | SNP1161 | 10 | 85927575 | A | G | SNP1840 | 23 | 61308089 | A | G |
SNP0483 | 3 | 112453567 | A | G | SNP1162 | 10 | 85927746 | A | G | SNP1841 | 23 | 61308155 | A | G |
SNP0484 | 3 | 112453992 | G | A | SNP1163 | 10 | 85928031 | G | A | SNP1842 | 23 | 61308212 | G | C |
SNP0485 | 3 | 112454014 | G | A | SNP1164 | 10 | 85928406 | C | G | SNP1843 | 23 | 61308330 | G | A |
SNP0486 | 3 | 112454206 | C | A | SNP1165 | 10 | 85920368 | C | A | SNP1844 | 23 | 61308364 | T | C |
SNP0487 | 3 | 112454596 | A | G | SNP1166 | 10 | 85929213 | T | C | SNP1845 | 23 | 61308674 | C | G |
SNP0488 | 3 | 112454782 | C | T | SNP1167 | 10 | 85929218 | A | G | SNP1846 | 23 | 61308703 | A | G |
SNP0489 | 3 | 112455498 | A | G | SNP1168 | 10 | 85929443 | T | C | SNP1847 | 23 | 61308810 | C | T |
SNP0490 | 3 | 112455617 | G | A | SNP1169 | 10 | 85930254 | G | C | SNP1848 | 23 | 61308952 | C | T |
SNP0491 | 3 | 112455838 | T | C | SNP1170 | 10 | 85930383 | G | C | SNP1849 | 23 | 61309358 | T | C |
SNP0492 | 3 | 112456755 | A | G | SNP1171 | 10 | 85930639 | G | C | SNP1850 | 23 | 61309536 | T | C |
SNP0493 | 3 | 112456834 | G | A | SNP1172 | 10 | 85931141 | C | T | SNP1851 | 23 | 61309700 | A | C |
SNP0494 | 3 | 112457235 | G | C | SNP1173 | 10 | 85931227 | A | C | SNP1852 | 23 | 61310018 | A | G |
SNP0495 | 3 | 112457494 | C | T | SNP1174 | 10 | 85931543 | T | C | SNP1853 | 23 | 61310224 | A | G |
SNP0496 | 3 | 112457690 | C | T | SNP1175 | 10 | 85931800 | G | A | SNP1854 | 23 | 61310269 | A | G |
SNP0497 | 3 | 112457722 | G | T | SNP1176 | 10 | 85932238 | A | C | SNP1855 | 23 | 61310652 | G | A |
SNP0498 | 3 | 112457726 | G | A | SNP1177 | 10 | 85932363 | C | T | SNP1856 | 23 | 61310797 | C | T |
SNP0499 | 3 | 112457769 | G | A | SNP1178 | 10 | 85932391 | G | A | SNP1857 | 23 | 61310843 | A | G |
SNP0500 | 3 | 112457794 | T | C | SNP1179 | 10 | 85932949 | C | T | SNP1858 | 23 | 61310936 | T | A |
SNP0501 | 3 | 112457820 | T | C | SNP1180 | 10 | 85933017 | T | C | SNP1859 | 23 | 61310965 | A | G |
SNP0502 | 3 | 112457856 | G | A | SNP1181 | 10 | 85933303 | G | A | SNP1860 | 23 | 61312119 | G | C |
SNP0503 | 3 | 112457890 | G | T | SNP1182 | 10 | 85933321 | A | G | SNP1861 | 23 | 61312213 | A | G |
SNP0504 | 3 | 112457915 | T | A | SNP1183 | 10 | 85933549 | T | C | SNP1862 | 23 | 61312504 | C | G |
SNP0505 | 3 | 112457927 | T | C | SNP1184 | 10 | 85933571 | G | A | SNP1863 | 23 | 61312770 | C | T |
SNP0506 | 3 | 112458069 | C | T | SNP1185 | 10 | 85933573 | C | T | SNP1864 | 23 | 61312775 | C | T |
SNP0507 | 3 | 112458074 | C | T | SNP1186 | 10 | 85934674 | G | A | SNP1865 | 23 | 61312900 | T | C |
SNP0508 | 3 | 112458104 | C | A | SNP1187 | 10 | 85934736 | G | A | SNP1866 | 23 | 61312927 | C | T |
SNP0509 | 3 | 112458143 | G | A | SNP1188 | 10 | 85934869 | T | C | SNP1867 | 23 | 61312984 | C | T |
SNP0510 | 3 | 112458208 | G | A | SNP1189 | 10 | 85934985 | T | C | SNP1868 | 23 | 61313068 | C | A |
SNP0511 | 3 | 112458509 | C | T | SNP1190 | 10 | 85934986 | G | A | SNP1869 | 23 | 61313074 | A | G |
SNP0512 | 3 | 112458660 | T | C | SNP1191 | 10 | 85935135 | G | A | SNP1870 | 23 | 61313315 | G | T |
SNP0513 | 3 | 112458819 | T | C | SNP1192 | 10 | 85935209 | C | A | SNP1871 | 23 | 61313319 | G | A |
SNP0514 | 3 | 112459046 | A | G | SNP1193 | 10 | 85935669 | T | C | SNP1872 | 23 | 61313446 | G | T |
SNP0515 | 3 | 112459118 | A | G | SNP1194 | 10 | 85935994 | C | T | SNP1873 | 23 | 61313567 | G | C |
SNP0516 | 3 | 112459141 | G | A | SNP1195 | 10 | 85937077 | G | A | SNP1874 | 23 | 61313575 | C | T |
SNP0517 | 3 | 112459150 | T | C | SNP1196 | 10 | 85937357 | T | C | SNP1875 | 23 | 61313633 | T | C |
SNP0518 | 3 | 112459341 | C | T | SNP1197 | 10 | 85937463 | T | A | SNP1876 | 23 | 61313669 | C | T |
SNP0519 | 3 | 112459722 | G | A | SNP1198 | 10 | 85937504 | C | T | SNP1877 | 23 | 61313861 | C | T |
SNP0520 | 3 | 112459793 | G | T | SNP1199 | 10 | 85937573 | C | T | SNP1878 | 23 | 61313930 | A | G |
SNP0521 | 3 | 112459896 | T | C | SNP1200 | 10 | 85937602 | C | T | SNP1879 | 23 | 61313939 | G | A |
SNP0522 | 3 | 112459947 | C | T | SNP1201 | 10 | 85937614 | C | T | SNP1880 | 23 | 61314070 | C | G |
SNP0523 | 3 | 112459998 | G | A | SNP1202 | 10 | 85937699 | A | G | SNP1881 | 23 | 61314221 | A | C |
SNP0524 | 3 | 112460055 | C | A | SNP1203 | 10 | 85937874 | G | A | SNP1882 | 23 | 61314247 | T | C |
SNP0525 | 3 | 112460440 | T | C | SNP1204 | 10 | 85938481 | A | C | SNP1883 | 23 | 61314333 | T | G |
SNP0526 | 3 | 112461252 | C | T | SNP1205 | 10 | 85939115 | T | A | SNP1884 | 23 | 61314348 | C | A |
SNP0527 | 3 | 112461368 | C | G | SNP1206 | 10 | 85939116 | C | A | SNP1885 | 23 | 61314446 | C | T |
SNP0528 | 3 | 112464846 | C | T | SNP1207 | 10 | 85942040 | A | G | SNP1886 | 23 | 61314921 | G | A |
SNP0529 | 3 | 112465011 | A | G | SNP1208 | 10 | 85943950 | T | C | SNP1887 | 23 | 61314960 | A | C |
SNP0530 | 3 | 112465121 | G | C | SNP1209 | 10 | 85944487 | A | T | SNP1888 | 23 | 61315017 | T | C |
SNP0531 | 3 | 112465192 | A | G | SNP1210 | 10 | 85946254 | C | T | SNP1889 | 23 | 61315555 | G | A |
SNP0532 | 3 | 112465500 | A | G | SNP1211 | 10 | 85946534 | G | A | SNP1890 | 23 | 61315659 | A | T |
SNP0533 | 3 | 112465620 | G | A | SNP1212 | 10 | 85946727 | G | A | SNP1891 | 23 | 61315722 | C | T |
SNP0534 | 3 | 112466096 | C | T | SNP1213 | 10 | 85947571 | A | G | SNP1892 | 23 | 61315833 | C | A |
SNP0535 | 3 | 112466444 | A | C | SNP1214 | 10 | 85947724 | A | G | SNP1893 | 23 | 61316103 | A | G |
SNP0536 | 3 | 112466522 | T | C | SNP1215 | 10 | 85949624 | T | C | SNP1894 | 23 | 61316109 | G | A |
SNP0537 | 3 | 112466614 | T | C | SNP1216 | 10 | 85949657 | G | A | SNP1895 | 23 | 61316145 | A | G |
SNP0538 | 3 | 112467209 | C | T | SNP1217 | 10 | 85949665 | A | G | SNP1896 | 23 | 61316192 | C | T |
SNP0539 | 3 | 112468348 | G | A | SNP1218 | 10 | 85950284 | G | A | SNP1897 | 23 | 61316234 | A | C |
SNP0540 | 3 | 112468501 | G | A | SNP1219 | 10 | 85951060 | G | A | SNP1898 | 23 | 61316270 | A | G |
SNP0541 | 3 | 112468640 | G | A | SNP1220 | 10 | 85953623 | G | T | SNP1899 | 23 | 61316306 | C | G |
SNP0542 | 3 | 112469121 | T | C | SNP1221 | 10 | 85954267 | C | T | SNP1900 | 23 | 61316566 | A | C |
SNP0543 | 3 | 112469222 | A | C | SNP1222 | 10 | 85954379 | G | A | SNP1901 | 23 | 61316662 | A | T |
SNP0544 | 3 | 112469323 | A | G | SNP1223 | 10 | 85954769 | A | G | SNP1902 | 23 | 61316682 | G | A |
SNP0545 | 3 | 112469384 | T | C | SNP1224 | 10 | 85955760 | A | G | SNP1903 | 23 | 61316710 | C | T |
SNP0546 | 3 | 112469514 | T | C | SNP1225 | 10 | 85955776 | C | T | SNP1904 | 23 | 61317066 | C | T |
SNP0547 | 3 | 112469522 | A | C | SNP1226 | 10 | 85955944 | G | A | SNP1905 | 23 | 61317466 | T | G |
SNP0548 | 3 | 112469553 | T | A | SNP1227 | 10 | 85956535 | C | T | SNP1906 | 23 | 61317586 | G | A |
SNP0549 | 3 | 112469650 | G | A | SNP1228 | 10 | 85957579 | C | T | SNP1907 | 23 | 61317909 | G | A |
SNP0550 | 3 | 112469728 | A | G | SNP1229 | 10 | 85957803 | G | A | SNP1908 | 23 | 61317995 | G | A |
SNP0551 | 3 | 112469744 | C | A | SNP1230 | 10 | 85958356 | C | T | SNP1909 | 23 | 61318031 | G | A |
SNP0552 | 3 | 112469765 | T | C | SNP1231 | 10 | 85958481 | G | A | SNP1910 | 23 | 61318033 | G | A |
SNP0553 | 3 | 112469823 | G | A | SNP1232 | 10 | 85958583 | C | G | SNP1911 | 23 | 61318069 | G | T |
SNP0554 | 3 | 112470495 | C | T | SNP1233 | 10 | 85959272 | G | A | SNP1912 | 23 | 61318193 | T | A |
SNP0555 | 3 | 112470506 | A | G | SNP1234 | 10 | 85959315 | C | T | SNP1913 | 23 | 61318235 | A | G |
SNP0556 | 3 | 112470512 | C | A | SNP1235 | 10 | 85959364 | C | T | SNP1914 | 23 | 61318354 | T | C |
SNP0557 | 3 | 112470898 | A | C | SNP1236 | 10 | 85959439 | C | T | SNP1915 | 23 | 61318679 | G | A |
SNP0558 | 3 | 112471325 | T | A | SNP1237 | 10 | 85959472 | G | A | SNP1916 | 23 | 61318948 | T | C |
SNP0559 | 3 | 112471397 | A | T | SNP1238 | 10 | 85960079 | T | C | SNP1917 | 23 | 61319424 | A | G |
SNP0560 | 3 | 112471472 | C | T | SNP1239 | 10 | 85960181 | C | T | SNP1918 | 23 | 61319456 | T | C |
SNP0561 | 3 | 112471566 | T | G | SNP1240 | 10 | 85960209 | G | C | SNP1919 | 23 | 61319481 | T | G |
SNP0562 | 3 | 112472058 | A | G | SNP1241 | 10 | 85960308 | G | A | SNP1920 | 23 | 61319498 | T | C |
SNP0563 | 3 | 112472138 | G | A | SNP1242 | 10 | 85960355 | C | T | SNP1921 | 23 | 61319610 | G | T |
SNP0564 | 3 | 112472274 | T | A | SNP1243 | 10 | 85964118 | A | T | SNP1922 | 23 | 61319685 | G | T |
SNP0565 | 3 | 112472285 | A | C | SNP1244 | 10 | 85964209 | T | C | SNP1923 | 23 | 61319703 | C | T |
SNP0566 | 3 | 112472448 | T | C | SNP1245 | 10 | 85965056 | A | G | SNP1924 | 23 | 61320017 | G | T |
SNP0567 | 3 | 112472644 | A | C | SNP1246 | 10 | 85967201 | G | A | SNP1925 | 23 | 61320366 | T | C |
SNP0568 | 3 | 112473231 | C | G | SNP1247 | 10 | 85967510 | A | G | SNP1926 | 23 | 61320486 | G | A |
SNP0569 | 3 | 112473345 | C | T | SNP1248 | 10 | 85967911 | A | G | SNP1927 | 23 | 61320608 | A | G |
SNP0570 | 3 | 112473370 | A | G | SNP1249 | 10 | 85968068 | G | A | SNP1928 | 23 | 61320628 | A | C |
SNP0571 | 3 | 112473673 | G | T | SNP1250 | 10 | 85968332 | G | A | SNP1929 | 23 | 61321388 | C | A |
SNP0572 | 3 | 112475835 | G | A | SNP1251 | 10 | 85968640 | A | G | SNP1930 | 23 | 61321411 | C | A |
SNP0573 | 3 | 112475975 | G | A | SNP1252 | 10 | 85970684 | T | C | SNP1931 | 23 | 61321849 | G | A |
SNP0574 | 3 | 112475991 | G | A | SNP1253 | 10 | 85971027 | T | C | SNP1932 | 23 | 61321863 | G | A |
SNP0575 | 3 | 112476100 | A | G | SNP1254 | 10 | 85971721 | C | A | SNP1933 | 23 | 61321876 | G | A |
SNP0576 | 3 | 112476147 | A | G | SNP1255 | 10 | 85972032 | G | T | SNP1934 | 23 | 61322278 | G | A |
SNP0577 | 3 | 112476910 | C | T | SNP1256 | 10 | 85972954 | A | G | SNP1935 | 23 | 61322360 | A | G |
SNP0578 | 3 | 112477160 | A | C | SNP1257 | 10 | 85974251 | C | T | SNP1936 | 23 | 61322841 | C | T |
SNP0579 | 3 | 112477197 | G | C | SNP1258 | 10 | 85974332 | G | C | SNP1937 | 23 | 61323676 | G | A |
SNP0580 | 3 | 112477338 | C | T | SNP1259 | 10 | 85974762 | G | T | SNP1938 | 23 | 61323766 | T | C |
SNP0581 | 3 | 112477394 | G | A | SNP1260 | 13 | 24350909 | A | G | SNP1939 | 23 | 61324562 | T | G |
SNP0582 | 3 | 112477625 | T | G | SNP1261 | 13 | 24351157 | A | G | SNP1940 | 23 | 61326006 | G | A |
SNP0583 | 3 | 112477878 | A | G | SNP1262 | 13 | 24351191 | A | G | SNP1941 | 23 | 61326011 | T | C |
SNP0584 | 3 | 112478843 | T | C | SNP1263 | 13 | 24351652 | T | C | SNP1942 | 23 | 61326066 | G | A |
SNP0585 | 3 | 112479266 | G | C | SNP1264 | 13 | 24351854 | A | G | SNP1943 | 23 | 61326081 | A | G |
SNP0586 | 3 | 112479754 | T | A | SNP1265 | 13 | 24352141 | G | A | SNP1944 | 23 | 61326342 | T | C |
SNP0587 | 3 | 112481474 | A | G | SNP1266 | 13 | 24352465 | A | C | SNP1945 | 23 | 61326539 | C | A |
SNP0588 | 3 | 112484324 | G | A | SNP1267 | 13 | 24352702 | G | A | SNP1946 | 23 | 61326591 | G | A |
SNP0589 | 3 | 112484996 | A | G | SNP1268 | 13 | 24352709 | T | C | SNP1947 | 23 | 61326657 | C | T |
SNP0590 | 3 | 112486847 | C | T | SNP1269 | 13 | 24352763 | G | A | SNP1948 | 23 | 61327052 | G | A |
SNP0591 | 3 | 112488463 | T | A | SNP1270 | 13 | 24353598 | T | C | SNP1949 | 23 | 61327069 | G | A |
SNP0592 | 3 | 112488510 | C | T | SNP1271 | 13 | 24353599 | G | A | SNP1950 | 23 | 61327116 | G | A |
SNP0593 | 3 | 112488679 | C | T | SNP1272 | 13 | 24354218 | G | C | SNP1951 | 23 | 61327120 | T | C |
SNP0594 | 3 | 112490191 | A | G | SNP1273 | 13 | 24354241 | G | A | SNP1952 | 23 | 61327246 | C | T |
SNP0595 | 3 | 112490882 | T | C | SNP1274 | 13 | 24354280 | A | G | SNP1953 | 23 | 61327424 | G | C |
SNP0596 | 3 | 112490897 | C | T | SNP1275 | 13 | 24354319 | T | G | SNP1954 | 23 | 61327575 | G | A |
SNP0597 | 3 | 112491070 | G | A | SNP1276 | 13 | 24354508 | A | C | SNP1955 | 23 | 61328078 | C | T |
SNP0598 | 3 | 112491273 | A | G | SNP1277 | 13 | 24354639 | A | G | SNP1956 | 23 | 61328276 | G | T |
SNP0599 | 3 | 112491383 | C | A | SNP1278 | 13 | 24354642 | A | G | SNP1957 | 23 | 61328503 | A | G |
SNP0600 | 3 | 112491407 | C | A | SNP1279 | 13 | 24354644 | C | T | SNP1958 | 23 | 61328877 | T | G |
SNP0601 | 3 | 112491458 | G | A | SNP1280 | 13 | 24354958 | C | T | SNP1959 | 23 | 61329577 | G | A |
SNP0602 | 3 | 112491521 | A | C | SNP1281 | 13 | 24355030 | C | T | SNP1960 | 23 | 61329736 | G | A |
SNP0603 | 3 | 112491837 | C | A | SNP1282 | 13 | 24355032 | G | T | SNP1961 | 23 | 61330071 | C | G |
SNP0604 | 3 | 112491865 | A | G | SNP1283 | 13 | 24355360 | A | G | SNP1962 | 23 | 61330131 | A | G |
SNP0605 | 3 | 112492308 | C | T | SNP1284 | 13 | 24355536 | T | C | SNP1963 | 23 | 61330475 | C | G |
SNP0606 | 3 | 112492363 | G | A | SNP1285 | 13 | 24355915 | T | A | SNP1964 | 23 | 61330902 | G | A |
SNP0607 | 3 | 112492817 | G | A | SNP1286 | 13 | 24355960 | A | T | SNP1965 | 23 | 61330971 | A | G |
SNP0608 | 3 | 112492871 | A | C | SNP1287 | 13 | 24356196 | C | G | SNP1966 | 23 | 61331157 | G | A |
SNP0609 | 3 | 112493502 | G | A | SNP1288 | 13 | 24356687 | G | A | SNP1967 | 23 | 61331175 | C | A |
SNP0610 | 3 | 112493560 | G | A | SNP1289 | 13 | 24356805 | A | G | SNP1968 | 23 | 61331386 | G | A |
SNP0611 | 3 | 112494021 | G | A | SNP1290 | 13 | 24356874 | G | A | SNP1969 | 23 | 61331440 | T | G |
SNP0612 | 3 | 112494398 | T | C | SNP1291 | 13 | 24357112 | C | T | SNP1970 | 23 | 61331532 | T | C |
SNP0613 | 3 | 112494482 | T | G | SNP1292 | 13 | 24357268 | C | T | SNP1971 | 23 | 61331600 | A | G |
SNP0614 | 3 | 112494631 | A | C | SNP1293 | 13 | 24360283 | A | G | SNP1972 | 23 | 61331767 | T | C |
SNP0615 | 3 | 112494845 | G | A | SNP1294 | 13 | 24360339 | A | G | SNP1973 | 23 | 61332239 | G | C |
SNP0616 | 3 | 112494923 | A | G | SNP1295 | 13 | 24360383 | T | C | SNP1974 | 23 | 61333119 | A | G |
SNP0617 | 3 | 112494930 | G | C | SNP1296 | 13 | 24360627 | G | A | SNP1975 | 23 | 61333465 | A | G |
SNP0618 | 3 | 112495665 | T | A | SNP1297 | 13 | 24360875 | C | A | SNP1976 | 23 | 61334004 | G | A |
SNP0619 | 3 | 112495738 | C | G | SNP1298 | 13 | 24361053 | C | A | SNP1977 | 23 | 61334084 | T | C |
SNP0620 | 3 | 112495767 | A | G | SNP1299 | 13 | 24361157 | T | C | SNP1978 | 23 | 61334147 | G | A |
SNP0621 | 3 | 112496384 | A | C | SNP1300 | 13 | 24361163 | T | C | SNP1979 | 23 | 61334424 | G | C |
SNP0622 | 3 | 112496631 | G | A | SNP1301 | 13 | 24361178 | G | A | SNP1980 | 23 | 61334458 | G | T |
SNP0623 | 3 | 112496739 | G | A | SNP1302 | 13 | 24361327 | T | G | SNP1981 | 23 | 61334567 | C | A |
SNP0624 | 3 | 112496831 | A | T | SNP1303 | 13 | 24361613 | A | T | SNP1982 | 23 | 61334588 | T | C |
SNP0625 | 3 | 112496845 | T | C | SNP1304 | 13 | 24361643 | G | A | SNP1983 | 23 | 61334611 | C | T |
SNP0626 | 3 | 112496932 | T | A | SNP1305 | 13 | 24361737 | G | A | SNP1984 | 23 | 61334663 | A | T |
SNP0627 | 3 | 112497023 | A | G | SNP1306 | 13 | 24361985 | C | T | SNP1985 | 23 | 61334744 | T | C |
SNP0628 | 3 | 112497412 | A | G | SNP1307 | 13 | 24362137 | C | G | SNP1986 | 23 | 61334784 | T | C |
SNP0629 | 3 | 112497454 | T | C | SNP1308 | 13 | 24362533 | G | A | SNP1987 | 23 | 61334806 | A | G |
SNP0630 | 3 | 112497834 | C | T | SNP1309 | 13 | 24365936 | G | T | SNP1988 | 23 | 61335287 | A | G |
SNP0631 | 3 | 112498521 | G | A | SNP1310 | 13 | 24380342 | A | G | SNP1989 | 23 | 61335595 | T | C |
SNP0632 | 3 | 112498524 | G | A | SNP1311 | 13 | 24380755 | A | G | SNP1990 | 23 | 61338138 | G | C |
SNP0633 | 3 | 112498606 | T | C | SNP1312 | 13 | 24381006 | G | A | SNP1991 | 23 | 61338288 | A | G |
SNP0634 | 3 | 112498638 | A | G | SNP1313 | 13 | 24381124 | G | C | SNP1992 | 23 | 61339402 | C | T |
SNP0635 | 3 | 112498653 | T | C | SNP1314 | 13 | 24381198 | G | T | SNP1993 | 23 | 61340045 | A | G |
SNP0636 | 3 | 112498749 | A | G | SNP1315 | 13 | 24381539 | A | G | SNP1994 | 23 | 61340137 | T | C |
Wherein the growth performance comprises a body length index or/body height index or/chest circumference index or/body weight index or/pre-slaughter live weight index or/dressing percentage index or/meat percentage index.
In order to achieve the technical purpose, the second aspect of the invention provides a meat sheep growth performance detection probe combination, and the probe combination detects the meat sheep growth performance SNP site combination of the first aspect.
In order to achieve the technical object of the present invention, the third aspect of the present invention provides a growth performance gene chip for meat sheep, which has the probe combination of the second aspect.
In order to achieve the technical object of the present invention, a kit for detecting growth performance of a meat sheep is provided in a fourth aspect of the present invention, which comprises the detection probe set of the second aspect or the gene chip of the third aspect.
In order to achieve the technical object of the present invention, a fifth aspect of the present invention provides the SNP site combination of the first aspect, the detection probe combination of the second aspect, the gene chip of the third aspect, or the kit of the fourth aspect, wherein the kit comprises:
(1) the application in screening sheep varieties;
(2) the application in sheep variety identification;
(3) the application in sheep breeding;
(4) the application in germplasm resource protection;
(5) application in germplasm resource improvement.
Has the advantages that:
1. the invention provides a SNP locus combination which is good in universality at home and abroad and is only composed of 2036 SNP loci of meat sheep relevant to growth performance based on the genetic resource research of a plurality of foreign meat sheep varieties and Chinese local meat sheep varieties.
2. Compared with the existing high-density chip, the probe combination, the gene chip and the kit formed on the basis of the growth performance SNP locus combination provided by the invention have the advantages of small flux, low cost, easier analysis, wide universality and wide market prospect.
Drawings
FIGS. 1-4 are Manhattan plots of growth traits in example 1 during SNP screening of different groups, respectively.
Fig. 5 is a result graph of the present application in which the determination result of the population threshold analysis is subjected to the significance test.
Detailed Description
The following examples further illustrate the present invention but are not to be construed as limiting the invention. Modifications or substitutions to methods, procedures, or conditions of the invention may be made without departing from the spirit and scope of the invention. The experimental procedures used in the following examples are all conventional procedures unless otherwise specified. Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
Example 1 growth Performance SNP site of meat sheep
1. Acquisition of Total SNP set
The method comprises the steps of carrying out high-depth sequencing on 248 meat sheep individuals including 16 wild sheep Asia Morvelon, 172 local breeds and 60 breeding breeds covering Asia, Europe, Africa and the middle east, wherein the average sequencing depth is 25.7 x, comparing with a sheep 4.0 reference genome (obtained from NCBI) issued in 2015 by two modes of SAMtols and GATK by applying a re-sequencing analysis process, and forming an SNP set by common results obtained by comparing the two modes, wherein the SNP set comprises 2836 ten thousand SNP sites.
Specifically, the high-depth sequencing of a plurality of meat sheep individuals is completed by a biological sequencing company, and the sequencing results completed by the biological sequencing company can achieve the technical purpose of the invention, which is not limited by the invention. According to the method, a Fastq file returned by a sequencing company is compared to a reference genome sheep v4.0 through BWA software to obtain a BAM file, a sample BAM file is analyzed by utilizing SAMtools and GATK software to obtain a VCF file containing group SNP typing information, VCF results obtained in the two modes are merged, and an SNP set containing 2836 ten thousand SNP sites is obtained after quality screening.
Specifically, the meat Sheep breeds used in the present invention include small tailed han Sheep, Sishui fur Sheep, cauda Han Sheep, placer Sheep from Shandong, Hu Sheep from Jiangsu, Ningxia Sheep from Ningxia, Allete Sheep, Pasteur Sheep, Dorper Sheep, merino Sheep (fine wool Sheep), merino Sheep, saffron, Mullerian black Sheep, Dolange Sheep, Waggir Sheep Sheep, Finland Sheep (Finnshel) from Finland, Weisang island Sheep (Ouessant), Shetland Sheep (Shetland), Soogote Sheep (Sologote), Solulan island Sheep (Gotland), Derenche Hechen Sheep (Drente Hehen), Bangla Sheep from Esche Sheep (Shega Sheep), Gagne Sheep (Shorgora), Boguer Sheep (Akeland), Gagne Sheep (Africa Sheep) from Africa Sheep (Africa Sheep), Gagne Sheep (Africa Sheep), Sheep (Africa Sheep) from Yan Sheep (Africa Sheep), Sheep (Africa Sheep) from Eben Fa Sheep), Sheep (Africa Sheep) from Eben Sheep (Sheep) from Eben, Wuda Sheep (Uda Sheep), Jialong Keyan Sheep from African Bukenna (Djallonk cell Sheep), Morse Sheep (Mossi Sheep), Sahellian Sheep (Sahellian Sheep), Kernel Sheep from West noncancylon (Cameroon Sheep), Arhua Sheep from Iraq (Awassi Sheep), Hamdani Sheep (Hamdani Sheep), Marzhe Sheep from Asbehabaijiang (Mazekh Sheep), Grey-Shiraz Sheep from Iran (Grey-Shiraz Sheep), Gekkel Sheep (Ghezel Sheep), African Sanli Sheep (Afshiari Sheep), Sharl Sheep (Shahr Sheep), Shal Sheep (Shal Sheep), Markui Sheep (Makui Sheep), Moghania Sheep (Morgana Sheep), Sheata Sheep from Bakura Sheep (Skura Sheep), Kakura Sheep from Askura Sheep (Askularn Sheep), and Haemarkshiro Sheep from Astro Sheep.
2. Screening of candidate genes and functional regions thereof
According to the method, the sheep varieties are grouped according to the obvious difference of growth traits between the domestic sheep varieties and the foreign sheep varieties, XP-CLR is used for sweeping the multi-locus allele frequency difference between each group of sheep to scan the functional region related to growth, meanwhile, pi ratio (namely pi value) is used for excavating the functional region related to growth in each group of sheep varieties, then the intersection of the two results is taken to screen out the functional region related to growth, Manhattan graphs generated by different groups of growth traits through XP-CLR are shown in figures 1-4, and the selection of the pi value is shown in the dotted lines in figures 1-4. Then, genes in the region are screened by referring to published gene research results, 11 candidate genes which are related to growth and have well-determined functions are finally determined, namely PECR, CSRP2, GRTP1, KIAA1217, EIF4G2, PHLPP1, ZNF687, LMBR1, FLNB, LINGO2 and POLR1A, and the functional regions corresponding to the candidate genes are further determined by perl scripts.
Specifically, in one embodiment of the invention, the sheep breeds are grouped according to the obvious differences of the domestic sheep breeds and foreign sheep breeds in growth traits, and the method comprises the following steps: since the growth characteristics of the saffron sheep and the weisang and the jungding sheep show significant differences, and the growth characteristics of the dobang sheep and the weisang and the jungding sheep show significant differences, respectively, the manhattan graph of the saffron Vs weisang sheep (SFK Vs OUE) shown in fig. 1, the manhattan graph of the saffron Vs jungding sheep (SFK Vs SHE) shown in fig. 2, the manhattan graph of the dupont sheep Vs weisang sheep (DPS Vs OUE) shown in fig. 3, and the manhattan graph of the junior sheep Vs shown in fig. 4, the junior sheep (DPS SHE) are formed by sweeping the above groups with XP-CLR.
3. Extraction of SNP sites corresponding to functional genes
Searching SNP sites corresponding to the functional regions of the candidate genes determined in the step 2 in the total SNP set by utilizing bedtools to obtain a site combination which is associated with 11 growth-related functional genes including PECR, CSRP2, GRTP1, KIAA1217, EIF4G2, PHLPP1, ZNF687, LMBR1, FLNB, LINGO2 and POLR1A and only comprises 2036 SNP sites.
EXAMPLE 2 preparation of SNP Gene chip for growth Performance of meat sheep
Based on the SNP site combinations obtained in example 1, a person skilled in the art can prepare SNP gene chips with growth performance of meat sheep in any way, and also can entrust the preparation of the SNP gene chips to bio-companies, which is not limited in the present invention, for example, Illumina company, Affymetrix company or Agilent company, and it should be noted that the gene chips prepared based on the SNP sites provided in example 1 of the present invention all belong to the protection scope of the present invention. In one embodiment of the present invention, the SNP chip for growth of meat sheep of the present application is prepared by a method of Illumina corporation, and the SNP chip comprises a glass substrate and 2036 magnetic beads in the pores of the substrate, wherein each magnetic bead is coupled with a probe for detecting the site represented by SNP0001-SNP2036 in example 1, and is used for detecting a target sample, wherein the 23-base sequence coupled to the end of the bead on the magnetic bead is an Address sequence and is also the 5' end of a DNA fragment, which is a tag sequence for identifying the micro bead. The 50 bases at the far end of the bead are 3' -terminal sequences, which are Probe sequences, and which complementarily hybridize to the target DNA and can recognize the site indicated by SNP0001-SNP2036 in example 1.
EXAMPLE 3 SNP detection kit
Based on the SNP site combinations obtained in example 1, a person skilled in the art can prepare SNP detection kits for growth performance of meat sheep in any way, and also can entrust biological companies to prepare the SNP detection kits, which are not limited in the present invention, for example, Illumina company, Affymetrix company, or Agilent company, and it should be noted that the detection kits prepared based on the SNP sites provided in example 1 of the present invention all belong to the protection scope of the present invention. In one embodiment of the present invention, in order to detect the target sample by using the gene chip provided in embodiment 2, the kit further comprises four labeled dideoxynucleotides, a polymerase, a biotin-labeled anti-streptavidin antibody, and a DNP-labeled anti-xenoantibody FC-terminal antibody.
EXAMPLE 4 detection of growth Performance of meat sheep
In one embodiment of the present invention, four labeled dideoxynucleotides and polymerase are added when the detection is performed using the gene chip prepared by the method provided by Illumina company, based on the SNP site combination obtained in example 1 or the SNP gene chip provided in example 2 or the SNP detection kit provided in example 3. Wherein A, T two nucleotides are labeled with DNP (dinitrobenzene), C, G two bases are labeled with biotin, polymerase adds a dideoxynucleotide at the 3' end of the probe and attaches a label at the same time, and then adds green fluorescence labeled streptavidin and red fluorescence labeled anti-DNP antibody. The green fluorescence labeled streptavidin specifically binds to biotin, and C, G bases with biotin are colored green. A red fluorescent-labeled anti-DNP antibody was bound to DNP to make A, T bp with DNP appear red, and a biotin-labeled anti-streptavidin antibody and a DNP-labeled anti-xenoantibody FC-terminal antibody were further added. The two antibodies are added to further amplify the fluorescent signal in cascade, and after the antibodies are combined, the free antibodies are washed away. Scanning was performed under a scanner. If the emitted light is green, the site of SNP binding is indicated to be homozygote of "G" base. If red light is emitted, the SNP site is homozygote of the A base. If the light intensity of the light of the two colors is not much, the SNP locus is a heterozygote of 'A' and 'G', if the light does not exist, the base deletion is judged, finally, the result values of the genotype frequencies of all the loci in the target sample are counted, namely, the frequencies of the reference type homozygote, the heterozygote, the mutant type homozygote and the base deletion in the 2036 loci are counted as frequency values, and the result values of the target sample are obtained after the frequency values of each genotype are accumulated.
And obtaining the judgment result of the target sample after the statistical result value is compared with the group threshold value.
Specifically, the population threshold value of the present application is obtained by analyzing a population exhibiting good growth characteristics (DPS-SFK) and a population exhibiting poor growth characteristics (OUE-SHE), in the same manner as above.
The significance test (independent sample ManWhitney U test) is carried out on the judgment results of the analysis of the population with good growth character performance (DPS-SFK) and the population with poor growth character performance (OUE-SHE), the results are shown in figure 5, as can be seen from the results in the figure, P is less than 0.01, the difference is extremely significant, and the judgment results obtained by adopting the method have accuracy and effectiveness.
Application example 1 screening of sheep breeds based on the site information of example 1
Selecting a sheep with stronger representativeness and larger popularization area of 3 unknown varieties (numbered as SZ01-SZ 03), preparing the SNP gene chip of the example 2 according to the site information provided by the example 1, detecting the growth performance of the 3 sheep varieties by using the kit provided by the example 3, comparing result values of reference homozygote, heterozygote, mutant homozygote and base deletion in 2036 sites of each sheep variety to be detected with a threshold value, and displaying the comparison result: the growth trait of accession SZ03 was poorly characterized.
The applicant breeds the sheep of the 3 unknown varieties under the same breeding condition, and observes and counts the growth and development conditions of the 3 unknown varieties in the last 2 years, and the observation shows that the growth of the numbers SZ01 and SZ02 is very fast and is obviously superior to that of SZ 03.
Industrial applications
The SNP marker, the SNP probe and the SNP chip which are prepared based on 2036 SNP loci provided by the application perform growth genetic evaluation on sheep individuals on a genome level so as to obtain higher breeding value estimation accuracy. The method selects the traits which are difficult to measure in the early stage, shortens the generation interval, accelerates the breeding process and further saves a large amount of breeding cost.
Claims (4)
1. The detection probe combination for the growth performance of the meat sheep is characterized by detecting the growth performance SNP locus combination of the meat sheep as shown in the table 1, wherein the physical position information of the detection probe combination is determined based on the sheep v4.0 genome sequence alignment;
wherein the SNP site combination comprises 2036 SNP sites which are covered in gene segments of PECR, CSRP2, GRTP1, KIAA1217, EIF4G2, PHLPP1, ZNF687, LMBR1, FLNB, LINGO2 and POLR 1A.
2. A gene chip for detecting growth performance of a meat sheep, which is loaded with the probe combination for detecting growth performance of a meat sheep according to claim 1.
3. A kit for detecting growth performance of a meat sheep, comprising the detection probe set according to claim 1 or the gene chip according to claim 2.
4. The detection probe combination of claim 1 or the gene chip of claim 2 or the kit of claim 3, having the use of any one of the following:
(1) the application in screening sheep varieties;
(2) the application in sheep variety identification;
(3) the application in sheep breeding;
(4) the application in germplasm resource protection;
(5) application in germplasm resource improvement.
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CN113249495A (en) * | 2021-06-29 | 2021-08-13 | 西北农林科技大学 | Sheep liquid phase chip and application thereof |
CN113278711B (en) * | 2021-07-21 | 2021-11-09 | 中国农业大学 | Gene chip, molecular probe combination, kit and application for sheep germplasm resource identification and pedigree reconstruction |
CN113265476B (en) * | 2021-07-21 | 2021-11-09 | 中国农业大学 | Gene chip, molecular probe combination, kit and application for analyzing milk production performance of sheep |
CN113278715A (en) * | 2021-07-23 | 2021-08-20 | 中国农业大学 | Gene chip for analyzing sheep papilla number, molecular probe combination, kit and application |
CN113278712B (en) * | 2021-07-23 | 2021-11-09 | 中国农业大学 | Gene chip, molecular probe combination, kit and application for analyzing sheep hair color |
CN113278716B (en) * | 2021-07-23 | 2021-11-09 | 中国农业大学 | Gene chip for analyzing characters for sheep wool, molecular probe combination, kit and application |
CN113278713B (en) * | 2021-07-23 | 2021-11-09 | 中国农业大学 | Gene chip, molecular probe combination, kit and application of sheep multi-angle character |
CN117089636B (en) * | 2023-10-20 | 2023-12-22 | 中国农业大学 | Molecular marker combination for analyzing goat meat performance and application |
CN117385060B (en) * | 2023-12-08 | 2024-03-26 | 中国科学院遗传与发育生物学研究所 | SNP marker related to sheep growth performance and application thereof |
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Effective date of registration: 20210723 Address after: 010010 701, building 1, University Science Park, intersection of Horqin Expressway and Genghis Khan street, Xincheng District, Hohhot, Inner Mongolia Autonomous Region Patentee after: Zhongke YUNPU (Inner Mongolia) gene Biotechnology Co.,Ltd. Address before: 100193 No. 2 Old Summer Palace West Road, Beijing, Haidian District Patentee before: CHINA AGRICULTURAL University |