CN112690925A - Special automatic gastric lavage device for rabbit experiment - Google Patents

Special automatic gastric lavage device for rabbit experiment Download PDF

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Publication number
CN112690925A
CN112690925A CN202011582038.6A CN202011582038A CN112690925A CN 112690925 A CN112690925 A CN 112690925A CN 202011582038 A CN202011582038 A CN 202011582038A CN 112690925 A CN112690925 A CN 112690925A
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China
Prior art keywords
pin
controller
experiment table
fixed
gastric lavage
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Granted
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CN202011582038.6A
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CN112690925B (en
Inventor
刘公言
高淑霞
孙海涛
白莉雅
刘策
杨丽萍
张召坤
姜文学
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Institute Animal Science and Veterinary Medicine of Shandong AAS
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Institute Animal Science and Veterinary Medicine of Shandong AAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D11/00—Washing devices or gaseous curative baths specially adapted to veterinary purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0266—Stands, holders or storage means for irrigation devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/027—Devices for holding the cannula in position, e.g. belts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0279—Cannula; Nozzles; Tips; their connection means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3561—Range local, e.g. within room or hospital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1042—Alimentary tract
    • A61M2210/1053—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The automatic gastric lavage device special for rabbit experiments comprises a double-layer base body and a controller, wherein a fixed experiment table and a movable experiment table are oppositely arranged on the base body, arc-shaped cavities are respectively arranged in the fixed experiment table and the movable experiment table, the fixed experiment table and the movable experiment table are spliced inside to form an experiment cavity, the experiment cavity is used for placing rabbits for gastric lavage experiments, and the fixed experiment table is connected with the movable experiment table through a linear push rod; a plunger pump is arranged on the base body, a medicine injection pipe is connected to the plunger pump, one end of the medicine injection pipe is connected with the plunger pump, and the other end of the medicine injection pipe is connected with the top of the movable experiment table through a fixing piece; still be equipped with detecting element on the base member, detecting element is used for detecting the environmental parameter on the base member, detecting element passes through the AD converter and links to each other with the controller, detecting element is including setting up temperature sensor and the pressure sensor in fixed laboratory bench one side and setting up the photoelectric sensor on fixed laboratory bench top.

Description

Special automatic gastric lavage device for rabbit experiment
The technical field is as follows:
the invention relates to an automatic gastric lavage device special for rabbit experiments.
Background art:
with the development of animal husbandry, the management of rabbits as economic animals in the breeding process is very important, and the survival rate and the yield of the rabbits can be ensured by a good breeding management technology. Generally, the rabbits are bred in cages, the cages occupy small space, the rabbit groups are conveniently managed, and the management method is a common management method for modern rabbit breeding.
In the process of raising the rabbits, a part of the rabbits can be used as experimental animals for scientific research personnel; the rabbit is one of the most commonly used animals in physiological, pharmacological and toxicological experiments and teaching, and plays a role in medical and medical research; in many rabbit experiments, the gastric lavage and intragastric administration of rabbits is a conventional operation, and drugs or experimental reagents are fed into the stomach of the rabbit, and the physiological reaction of the rabbit is checked to obtain the drug properties of the drugs or the performance of the experimental reagents, so that the components or the components of the drugs or the experimental reagents can be adjusted to meet the requirements of human bodies.
In current rabbit gastric lavage experimental operation, need fix the rabbit on box or shelf, adopt artificial mode again to send into the stomach of rabbit with medicine or experimental agent through irritating the stomach tube, owing to adopt manual operation's mode, often can have following problem: (1) the rabbit is fixed on the box body or the frame, so that the movement of the rabbit is completely limited, the severe resistance of the rabbit can be caused, the rabbit is easy to be damaged, and the gavage tube is difficult to be smoothly inserted into the rabbit body, so that the experimental process is influenced; (2) the mode of manual gastric lavage one by one is adopted, the operation steps are complicated, the actual workload is large, the overall working efficiency is low, and careless leakage and errors are easy to occur in the experiment operation steps.
The invention content is as follows:
the embodiment of the invention provides an automatic gastric lavage device special for rabbit experiments, which is reasonable in structural design, based on the integrated control principle of a controller, and combined with a split type fixed structure, can stably limit the position of a rabbit, automatically perform gastric lavage and drug injection on the rabbit, avoid the rabbit from being damaged, and ensure the smooth performance of the experiments; meanwhile, the efficiency of the whole work can be improved, and the experimental error is reduced, so that the experimental result is accurate and reliable, and the problems in the prior art are solved.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the automatic gastric lavage device special for rabbit experiments comprises a double-layer base body and a controller, wherein a fixed experiment table and a movable experiment table are oppositely arranged on the base body, arc-shaped cavities are respectively arranged in the fixed experiment table and the movable experiment table, the fixed experiment table and the movable experiment table are spliced inside to form an experiment cavity, the experiment cavity is used for placing rabbits for gastric lavage experiments, and the fixed experiment table is connected with the movable experiment table through a linear push rod; a plunger pump is arranged on the base body, a medicine injection pipe is connected to the plunger pump, one end of the medicine injection pipe is connected with the plunger pump, and the other end of the medicine injection pipe is connected with the top of the movable experiment table through a fixing piece; the detection unit is also arranged on the base body and used for detecting environmental parameters on the base body and is connected with the controller through an AD converter, the detection unit comprises a temperature sensor and a pressure sensor which are arranged on one side of the fixed experiment table and a photoelectric sensor which is arranged at the top end of the fixed experiment table, the photoelectric sensor is used for detecting the distance between the fixed experiment table and the movable experiment table, and a groove matched with the photoelectric sensor is also arranged in the movable experiment table; an experiment unit is arranged on one side of the movable experiment table and used for detecting physiological parameters of the rabbits, and the controller is connected with the experiment unit through a wireless transceiver; the controller is correspondingly connected with the plunger pump and the linear push rod through the infrared transceiver and the driver respectively; the controller is connected with the upper computer through a 485 communicator.
The fixing piece comprises a fixing seat, the middle part of the fixing seat is provided with a through hole matched with the medicine injection tube, and an anti-skid rubber mat is arranged in the through hole; the top of the fixed seat is provided with a level gauge to prevent the fixed seat from sending and shaking.
An insulating outer cover is covered outside the base body to eliminate electrical interference.
The base member passes through locking mechanism and links to each other with insulating dustcoat, locking mechanism includes the fixed plate that links to each other with base member and insulating dustcoat, is connected with the handle through the pivot on the fixed plate, is connected with the locking arm through the pivot in the handle middle section, is equipped with the spacing groove in one side that the base member is kept away from to the fixed plate, is connected with the briquetting through the screw rod on the locking arm to lock base member and insulating dustcoat.
The movable experiment table is connected with the base body through the translation mechanism, the translation mechanism comprises a plurality of pulleys arranged at equal intervals, the pulleys are connected through a rotating shaft, a plurality of sliding rails matched with the pulleys are arranged on the base body, a balancing weight is arranged in the middle section of the rotating shaft, and the balancing weight is used for preventing the pulleys from falling off from the sliding rails.
A plurality of air holes are arranged on the insulating outer cover, and a filter screen is respectively arranged on each air hole.
The controller is of the model STM32F072C, 48 pins are arranged on the controller, crystal oscillators are arranged on a third pin and a fourth pin of the controller, a second capacitor and a third capacitor which are connected in parallel are arranged on the crystal oscillators, and a seventh pin of the controller is grounded through a first capacitor; the controller links to each other with wireless transceiver through No. twelve pin and No. thirteen pin, the controller links to each other with infrared transceiver through No. twenty pin, the controller links to each other with the AD converter through No. twenty-five pin, the controller links to each other with the 485 communication wares through No. thirty-one pin, No. thirty-two pin and No. thirty-three pin.
The model of the wireless transceiver is ESP8266, 8 pins are arranged on the wireless transceiver, a fourth pin of the wireless transceiver is connected with a twelfth pin of the controller, and an eighth pin of the wireless transceiver is connected with a thirteenth pin of the controller; the experimental unit at least comprises a sphygmomanometer, a pulse counter and a CT scanner.
The type of the infrared transceiver is HC-SR505, and a pin V of the infrared transceiver is connected with a pin twenty of the controller; the type of the driver is ULN2003, 16 pins are arranged on the driver, a first pin and a seventh pin of the driver are connected with a second pin of the infrared transceiver, a sixteenth pin of the driver is connected with a linear push rod interface through a first relay, and a first diode and a first resistor are connected in parallel on the first relay; and a tenth pin of the driver is connected with a plunger pump interface through a second relay, and a second diode and a second resistor are connected in parallel on the second relay.
The type of the AD converter is AD8551, 8 pins are arranged on the AD converter, and a pin number six of the AD converter is connected with a pin number twenty-five of the controller; a temperature sensor, a pressure sensor and a photoelectric sensor are connected to the second pin and the third pin of the AD converter; the model of the temperature sensor is SHT20, the model of the pressure sensor is MIK-P300, and the model of the photoelectric sensor is OH-1021.
By adopting the structure, the fixed experiment table and the movable experiment table are spliced to form the experiment cavity for placing the rabbits for gastric lavage experiments, the experiment cavity is formed by splicing two arc-shaped cavities, and can protect the rabbits, limit the positions of the rabbits and protect the rabbits; conveying the medicines or experimental reagents to the stomach of the rabbit through a plunger pump and a medicine injection tube, and ensuring that the medicine injection tube does not deviate greatly by matching with a fixing part; the controller, the AD converter, the wireless transceiver, the infrared transceiver and the 485 communicator are used for controlling the actions of the experiment unit, the detection unit, the plunger pump and the linear push rod to form a qualified experiment space, so that automatic gastric lavage and medicine injection is realized, the physiological parameters of the rabbits are automatically detected, data can be transmitted to an upper computer, and the checking by workers is facilitated; the electric interference is eliminated through the insulating outer cover outside the base body, and a proper experimental environment is provided for the rabbits by combining the air holes and the filter screen, so that the accuracy of an experimental result is improved; the insulating outer cover and the base body are locked through the locking mechanism to form a closed experimental space so as to avoid the interference of external environmental parameters, and the device has the advantages of practicality, accuracy, simplicity, convenience and high efficiency.
Description of the drawings:
FIG. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic structural diagram of a fixed laboratory table and a movable laboratory table of the present invention.
Fig. 3 is a schematic structural view of the fixing member of the present invention.
Fig. 4 is a schematic structural diagram of the translation mechanism of the present invention.
Fig. 5 is a schematic structural view of the locking mechanism of the present invention.
Fig. 6 is a control schematic of the present invention.
FIG. 7 is a schematic structural diagram of a detecting unit according to the present invention.
FIG. 8 is a schematic structural diagram of an experimental unit according to the present invention.
Fig. 9 is an electrical schematic of the controller of the present invention.
Fig. 10 is an electrical schematic diagram of the AD converter of the present invention.
Fig. 11 is an electrical schematic of the temperature sensor of the present invention.
Fig. 12 is a schematic structural view of the pressure sensor of the present invention.
Fig. 13 is a schematic structural diagram of a photoelectric sensor according to the present invention.
Fig. 14 is an electrical schematic diagram of the wireless transceiver of the present invention.
Fig. 15 is an electrical schematic of the 485 communicator of the present invention.
Fig. 16 is an electrical schematic of an infrared transceiver of the present invention.
Fig. 17 is an electrical schematic of the actuator of the present invention.
In the figure, 1, a base body, 2, a fixed experiment table, 3, a movable experiment table, 4, an arc cavity, 5, a linear push rod, 6, a plunger pump, 7, a medicine injection pipe, 8, a detection unit, 9, a groove, 10, an experiment unit, 11, a wireless transceiver, 12, an infrared transceiver, 13, a fixed seat, 14, a through hole, 15, an anti-skid rubber pad, 16, a gradienter, 17, an insulating outer cover, 18, a fixed plate, 19, a handle, 20, a locking arm, 21, a limiting groove, 22, a screw rod, 23, a pressing block, 24, a pulley, 25, a sliding rail, 26, a balancing weight, 27, an air hole, 28 and a filter screen.
The specific implementation mode is as follows:
in order to clearly explain the technical features of the present invention, the following detailed description of the present invention is provided with reference to the accompanying drawings.
As shown in fig. 1-17, the special automatic gastric lavage device for rabbit experiments comprises a double-layer base 1 and a controller, wherein a fixed experiment table 2 and a movable experiment table 3 are oppositely arranged on the base 1, arc-shaped cavities 4 are respectively arranged in the fixed experiment table 2 and the movable experiment table 3, the fixed experiment table 2 and the movable experiment table 3 are spliced inside to form an experiment cavity, the experiment cavity is used for placing rabbits for gastric lavage experiments, and the fixed experiment table 2 is connected with the movable experiment table 3 through a linear push rod 5; a plunger pump 6 is arranged on the base body 1, a medicine injection pipe 7 is connected to the plunger pump 6, one end of the medicine injection pipe 7 is connected with the plunger pump 6, and the other end of the medicine injection pipe is connected with the top of the movable experiment table 3 through a fixing piece; the detection device is characterized in that a detection unit 8 is further arranged on the base body 1, the detection unit 8 is used for detecting environmental parameters on the base body 1, the detection unit 8 is connected with a controller through an AD converter, the detection unit 8 comprises a temperature sensor and a pressure sensor which are arranged on one side of the fixed experiment table 2 and a photoelectric sensor which is arranged at the top end of the fixed experiment table 2, the photoelectric sensor is used for detecting the distance between the fixed experiment table 2 and the movable experiment table 3, and a groove 9 matched with the photoelectric sensor is further arranged in the movable experiment table 3; an experiment unit 10 is arranged on one side of the movable experiment table 3, the experiment unit 10 is used for detecting physiological parameters of the rabbits, and the controller is connected with the experiment unit through a wireless transceiver 11; the controller is correspondingly connected with the plunger pump 6 and the linear push rod 5 through the infrared transceiver 12 and the driver respectively; the controller is connected with the upper computer through a 485 communicator.
The fixing piece comprises a fixing seat 13, a through hole 14 matched with the medicine injection pipe 7 is formed in the middle of the fixing seat 13, and an anti-skid rubber pad 15 is arranged in the through hole 14; a level gauge 16 is provided on the top of the fixed base 13 to prevent the fixed base 13 from sending jolts.
An insulating cover 17 is arranged outside the base body 1 to eliminate electrical interference.
The base body 1 is connected with the insulating outer cover 17 through a locking mechanism, the locking mechanism comprises a fixing plate 18 connected with the base body 1 and the insulating outer cover 17, a handle 19 is connected to the fixing plate 18 through a rotating shaft, a locking arm 20 is connected to the middle section of the handle 19 through a rotating shaft, a limiting groove 21 is formed in one side, far away from the base body, of the fixing plate 18, and a pressing block 23 is connected to the locking arm 20 through a screw rod 22 so as to lock the base body 1 and the insulating outer cover 17.
The activity laboratory bench 3 links to each other with base member 1 through translation mechanism, translation mechanism includes the pulley 24 of a plurality of equidistant settings, pulley 24 links to each other through the pivot, is equipped with a plurality of slide rails 25 with 24 matched with of pulley on base member 1, is equipped with balancing weight 26 in the middle section of pivot, balancing weight 26 is used for preventing that pulley 24 from droing from slide rail 25.
A plurality of air holes 27 are arranged on the insulating outer cover 17, and a filter screen 28 is respectively arranged on each air hole 27.
The controller is of the model STM32F072C, 48 pins are arranged on the controller, crystal oscillators are arranged on a third pin and a fourth pin of the controller, a second capacitor and a third capacitor which are connected in parallel are arranged on the crystal oscillators, and a seventh pin of the controller is grounded through a first capacitor; the controller is connected with the wireless transceiver 11 through a twelve-number pin and a thirteen-number pin, the controller is connected with the infrared transceiver 12 through a twenty-number pin, the controller is connected with the AD converter through a twenty-five-number pin, and the controller is connected with the 485 communicator through a thirty-one-number pin, a thirty-two-number pin and a thirty-three-number pin.
The model of the wireless transceiver 11 is ESP8266, 8 pins are arranged on the wireless transceiver 11, a fourth pin of the wireless transceiver 11 is connected with a twelfth pin of the controller, and an eighth pin of the wireless transceiver 11 is connected with a thirteenth pin of the controller; the experimental unit 10 at least comprises a sphygmomanometer, a pulse counter and a CT scanner.
The type of the infrared transceiver 12 is HC-SR505, and a pin V of the infrared transceiver 12 is connected with a pin twenty of the controller; the type of the driver is ULN2003, 16 pins are arranged on the driver, a first pin and a seventh pin of the driver are connected with a second pin of the infrared transceiver 12, a sixteen pin of the driver is connected with a linear push rod interface through a first relay, and the first relay is connected with a first diode and a first resistor in parallel; and a tenth pin of the driver is connected with a plunger pump interface through a second relay, and a second diode and a second resistor are connected in parallel on the second relay.
The type of the AD converter is AD8551, 8 pins are arranged on the AD converter, and a pin number six of the AD converter is connected with a pin number twenty-five of the controller; a temperature sensor, a pressure sensor and a photoelectric sensor are connected to the second pin and the third pin of the AD converter; the model of the temperature sensor is SHT20, the model of the pressure sensor is MIK-P300, and the model of the photoelectric sensor is OH-1021.
The working principle of the automatic gastric lavage device special for rabbit experiments in the embodiment of the invention is as follows: based on the integrated control principle of the controller, the device is combined with a split type fixing structure, the position of the rabbit can be stably limited, the rabbit is automatically subjected to gastric lavage and drug injection, the rabbit is prevented from being damaged, and the smooth operation of an experiment is ensured; meanwhile, the overall working efficiency can be improved, and experimental errors are reduced, so that the accuracy and reliability of experimental results are ensured; the controller is connected with various types of electrical components through a lead, a 485 communicator, a wireless transceiver 11, an infrared transceiver 12 and an AD converter to form a complete electrical structure, automatic gastric lavage experiment operation is carried out on the rabbits by the aid of the electrical structure, and medicines or experimental reagents are conveyed to the stomachs of the rabbits to be observed or experimented so as to feed back the characteristics of the medicines or the experimental reagents to workers.
Before the experiment begins, the environmental parameters on the base body 1 are detected through the temperature sensor and the pressure sensor of the detection unit 8, and the environmental parameters are guaranteed to meet the experiment requirements.
In the integral scheme, the arc-shaped cavities 4 in the fixed experiment table 2 and the movable experiment table 3 are spliced to form an experiment cavity, compared with the existing cylindrical cavity, the rabbit can be well fixed according to the body shape design of the rabbit, and the rabbit cannot be damaged; in the using process, firstly, the rabbit is placed in the arc-shaped cavity 4 in the fixed experiment table 2, the controller sends an instruction to the linear push rod 5 through the infrared transceiver 12 and the driver, the linear push rod 5 drives the movable experiment table 3 to move towards the direction of the fixed experiment table 2 under the coordination of the translation mechanism at the bottom of the movable experiment table 3, and the balancing weight 26 in the translation mechanism can prevent the pulley 24 from falling off from the slide rail 25, so that the stable operation of the movement is ensured; in the moving process, the photoelectric sensor can also detect the distance between the two experiment tables until the photoelectric sensor stretches into the groove 9 to stop, an experiment cavity is formed, and the positioning of the rabbit is completed.
After the positioning of the rabbits is finished, the injection and gastric lavage can be carried out, the injection tube 7 is inserted into the mouth of the rabbits, generally, the champignon or smell for attracting the rabbits is arranged above the injection tube 7, and the experiment is convenient to carry out; the controller sends an instruction to the plunger pump 6 through the infrared transceiver 12 and the driver so as to inject the medicine or the experimental reagent into the stomach of the rabbit; the injection tube 7 is fixed through a through hole 14 and an anti-skid rubber pad 15 on the fixing piece, and is matched with a level gauge 16 to prevent shaking in the injection process.
In the process of injecting the medicine, the controller establishes wireless communication with the experiment unit 10 through the wireless transceiver 11 to obtain physiological parameters of the rabbits in the medicine injection, and obtains corresponding medicine or experiment reagent data according to the change of the physiological parameters of the rabbits; in the experimental unit 10, including at least a sphygmomanometer, a pulse counter and a CT scanner, the number and types of the instruments can be increased or adjusted according to the requirements of the actual experiment.
In the experiment process, the pressing block 23 can be pressed between the base body 1 and the insulating outer cover 17 through the matching of the handle 19, the locking arm 20 and the limiting groove 21 on the locking mechanism, so that the base body 1 is sealed; the insulating outer cover 17 is provided with a plurality of air holes 27, and each air hole 27 is provided with a filter screen 28 respectively so as to provide pure air for the rabbits.
Specifically, the controller is of the model STM32F072C, 48 pins are arranged on the controller, a crystal oscillator is arranged on a pin III and a pin IV of the controller, a second capacitor and a third capacitor which are connected in parallel are arranged on the crystal oscillator, and a pin VII of the controller is grounded through a first capacitor; the controller is connected with the wireless transceiver 11 through a twelve-number pin and a thirteen-number pin, the controller is connected with the infrared transceiver 12 through a twenty-number pin, the controller is connected with the AD converter through a twenty-five-number pin, and the controller is connected with the 485 communicator through a thirty-one-number pin, a thirty-two-number pin and a thirty-three-number pin.
The model of the wireless transceiver 11 is ESP8266, 8 pins are arranged on the wireless transceiver 11, a fourth pin of the wireless transceiver 11 is connected with a twelfth pin of the controller, and an eighth pin of the wireless transceiver 11 is connected with a thirteenth pin of the controller; the type of the infrared transceiver 12 is HC-SR505, and a pin V of the infrared transceiver 12 is connected with a pin twenty of the controller; the model of the driver is ULN2003, 16 pins are arranged on the driver, a first pin and a seventh pin of the driver are connected with a second pin of the infrared transceiver 12, a sixteen pin of the driver is connected with a linear push rod interface through a first relay, and the first relay is connected with a first diode and a first resistor in parallel; a tenth pin of the driver is connected with a plunger pump interface through a second relay, and a second diode and a second resistor are connected in parallel on the second relay; the type of the AD converter is AD8551, 8 pins are arranged on the AD converter, and a pin VI of the AD converter is connected with a pin twenty-five of the controller; a temperature sensor, a pressure sensor and a photoelectric sensor are connected to the second pin and the third pin of the AD converter; the model of the temperature sensor is SHT20, the model of the pressure sensor is MIK-P300, and the model of the photoelectric sensor is OH-1021.
The electric element with the type can well perform a test process; the same principle can set up a plurality of devices simultaneously and carry out the experiment operation to many rabbits, and the staff just only need carry out the data acquisition and the observation in later stage after the rabbit is placed and finishes, compares with the mode that current manual work was tested one by one, has alleviateed actual work load, has promoted work efficiency, and the experimental result that obtains is more accurate.
In particular, the automatic gastric lavage device special for rabbit experiments in the embodiment of the invention is mainly applied to laboratories or pet hospitals, and verifies the efficacy of drugs or experimental reagents by observing the changed physiological parameters of rabbits, or helps the pet rabbits in the pet hospitals to treat.
The above-described embodiments should not be construed as limiting the scope of the invention, and any alternative modifications or alterations to the embodiments of the present invention will be apparent to those skilled in the art.
The present invention is not described in detail, but is known to those skilled in the art.

Claims (10)

1. The special automatic gastric lavage device for rabbit experiments is characterized in that: the device comprises a double-layer base body and a controller, wherein a fixed experiment table and a movable experiment table are oppositely arranged on the base body, arc-shaped cavities are respectively arranged in the fixed experiment table and the movable experiment table, the fixed experiment table and the movable experiment table are spliced inside to form an experiment cavity, the experiment cavity is used for placing rabbits for gastric lavage experiments, and the fixed experiment table is connected with the movable experiment table through a linear push rod; a plunger pump is arranged on the base body, a medicine injection pipe is connected to the plunger pump, one end of the medicine injection pipe is connected with the plunger pump, and the other end of the medicine injection pipe is connected with the top of the movable experiment table through a fixing piece; the detection unit is also arranged on the base body and used for detecting environmental parameters on the base body and is connected with the controller through an AD converter, the detection unit comprises a temperature sensor and a pressure sensor which are arranged on one side of the fixed experiment table and a photoelectric sensor which is arranged at the top end of the fixed experiment table, the photoelectric sensor is used for detecting the distance between the fixed experiment table and the movable experiment table, and a groove matched with the photoelectric sensor is also arranged in the movable experiment table; an experiment unit is arranged on one side of the movable experiment table and used for detecting physiological parameters of the rabbits, and the controller is connected with the experiment unit through a wireless transceiver; the controller is correspondingly connected with the plunger pump and the linear push rod through the infrared transceiver and the driver respectively; the controller is connected with the upper computer through a 485 communicator.
2. The automatic gastric lavage device special for rabbit experiments according to claim 1, characterized in that: the fixing piece comprises a fixing seat, the middle part of the fixing seat is provided with a through hole matched with the medicine injection tube, and an anti-skid rubber mat is arranged in the through hole; the top of the fixed seat is provided with a level gauge to prevent the fixed seat from sending and shaking.
3. The automatic gastric lavage device special for rabbit experiments according to claim 1, characterized in that: an insulating outer cover is covered outside the base body to eliminate electrical interference.
4. The automatic gastric lavage device special for rabbit experiments according to claim 3, characterized in that: the base member passes through locking mechanism and links to each other with insulating dustcoat, locking mechanism includes the fixed plate that links to each other with base member and insulating dustcoat, is connected with the handle through the pivot on the fixed plate, is connected with the locking arm through the pivot in the handle middle section, is equipped with the spacing groove in one side that the base member is kept away from to the fixed plate, is connected with the briquetting through the screw rod on the locking arm to lock base member and insulating dustcoat.
5. The automatic gastric lavage device special for rabbit experiments according to claim 1, characterized in that: the movable experiment table is connected with the base body through the translation mechanism, the translation mechanism comprises a plurality of pulleys arranged at equal intervals, the pulleys are connected through a rotating shaft, a plurality of sliding rails matched with the pulleys are arranged on the base body, a balancing weight is arranged in the middle section of the rotating shaft, and the balancing weight is used for preventing the pulleys from falling off from the sliding rails.
6. The automatic gastric lavage device special for rabbit experiments according to claim 3, characterized in that: a plurality of air holes are arranged on the insulating outer cover, and a filter screen is respectively arranged on each air hole.
7. The automatic gastric lavage device special for rabbit experiments according to claim 1, characterized in that: the controller is of the model STM32F072C, 48 pins are arranged on the controller, crystal oscillators are arranged on a third pin and a fourth pin of the controller, a second capacitor and a third capacitor which are connected in parallel are arranged on the crystal oscillators, and a seventh pin of the controller is grounded through a first capacitor; the controller links to each other with wireless transceiver through No. twelve pin and No. thirteen pin, the controller links to each other with infrared transceiver through No. twenty pin, the controller links to each other with the AD converter through No. twenty-five pin, the controller links to each other with the 485 communication wares through No. thirty-one pin, No. thirty-two pin and No. thirty-three pin.
8. The automatic gastric lavage device special for rabbit experiments according to claim 7, characterized in that: the model of the wireless transceiver is ESP8266, 8 pins are arranged on the wireless transceiver, a fourth pin of the wireless transceiver is connected with a twelfth pin of the controller, and an eighth pin of the wireless transceiver is connected with a thirteenth pin of the controller; the experimental unit at least comprises a sphygmomanometer, a pulse counter and a CT scanner.
9. The automatic gastric lavage device special for rabbit experiments according to claim 7, characterized in that: the type of the infrared transceiver is HC-SR505, and a pin V of the infrared transceiver is connected with a pin twenty of the controller; the type of the driver is ULN2003, 16 pins are arranged on the driver, a first pin and a seventh pin of the driver are connected with a second pin of the infrared transceiver, a sixteenth pin of the driver is connected with a linear push rod interface through a first relay, and a first diode and a first resistor are connected in parallel on the first relay; and a tenth pin of the driver is connected with a plunger pump interface through a second relay, and a second diode and a second resistor are connected in parallel on the second relay.
10. The automatic gastric lavage device special for rabbit experiments according to claim 7, characterized in that: the type of the AD converter is AD8551, 8 pins are arranged on the AD converter, and a pin number six of the AD converter is connected with a pin number twenty-five of the controller; a temperature sensor, a pressure sensor and a photoelectric sensor are connected to the second pin and the third pin of the AD converter; the model of the temperature sensor is SHT20, the model of the pressure sensor is MIK-P300, and the model of the photoelectric sensor is OH-1021.
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CN115737962A (en) * 2022-11-08 2023-03-07 中国人民解放军空军军医大学 Thoracic surgery operation washing unit

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