CN112683826A - Correction method and device of calibration color plate for percutaneous jaundice tester - Google Patents
Correction method and device of calibration color plate for percutaneous jaundice tester Download PDFInfo
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- CN112683826A CN112683826A CN202011557708.9A CN202011557708A CN112683826A CN 112683826 A CN112683826 A CN 112683826A CN 202011557708 A CN202011557708 A CN 202011557708A CN 112683826 A CN112683826 A CN 112683826A
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- 238000000034 method Methods 0.000 title claims abstract description 35
- 206010023126 Jaundice Diseases 0.000 title claims abstract description 29
- 238000012937 correction Methods 0.000 title claims abstract description 7
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims abstract description 110
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 53
- 238000002310 reflectometry Methods 0.000 claims abstract description 20
- 238000012360 testing method Methods 0.000 claims description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- 238000004590 computer program Methods 0.000 claims description 6
- 238000012935 Averaging Methods 0.000 claims description 5
- 238000005259 measurement Methods 0.000 claims description 5
- 238000007865 diluting Methods 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 abstract description 2
- 206010023138 Jaundice neonatal Diseases 0.000 description 3
- 201000006346 Neonatal Jaundice Diseases 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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Abstract
The invention discloses a method and a device for correcting a calibration color plate for a percutaneous jaundice tester, wherein the method comprises the following steps: measuring the reflectivity of N bilirubin reagents with different concentrations at a preset wavelength by using a spectrophotometer to obtain N reagent reflection data, wherein the concentration range of the bilirubin reagents is determined according to the nominal value of a corrected standard color plate; performing linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relation between the bilirubin concentration and the reagent reflection data; measuring the reflectivity of the corrected standard color plate at the preset wavelength for N times by using a spectrophotometer to obtain N color plate reflection data, and obtaining N fitting values according to the linear relation; and (4) subtracting the fitting value from the nominal value of the corrected standard color plate, summing the difference values and taking the average value to obtain an error value of the corrected standard color plate. The method does not need to manually collect human body samples, is simpler and more convenient to operate, and has higher accuracy of error correction results obtained through linear calculation.
Description
Technical Field
The invention relates to the technical field of calibration in the field of medical instruments, in particular to a method and a device for correcting a calibration color plate for a percutaneous jaundice tester.
Background
Neonatal jaundice is one of the most common clinical problems of newborns, and the reason is that bilirubin level is increased due to abnormal bilirubin metabolism, so that skin, mucous membrane and sclera yellow staining characteristics appear, and therefore, the method for timely and effectively detecting bilirubin concentration of a neonatal jaundice patient is a key for early discovery, screening and treatment of pathological jaundice.
Currently, a method for detecting bilirubin concentration of a newborn widely used in medical institutions is a non-invasive method, which is to measure percutaneous bilirubin, and because there is a correlation between a percutaneous bilirubin value and a trace amount bilirubin value, a percutaneous jaundice tester is generally used to measure the percutaneous bilirubin values of the forehead, the anterior chest wall, the left and right cheeks, and other parts of the newborn to determine jaundice. Therefore, whether the measurement result of the percutaneous jaundice tester is accurate or not becomes an important factor affecting the treatment and monitoring of the neonatal jaundice patient.
The types of percutaneous jaundice testers used clinically are many, the most common calibration method of the percutaneous jaundice tester is a standard plate method, but a uniform correction method does not exist for a standard color plate used in the standard plate method.
In the prior art, the standard color plate is mainly corrected by an instrument clinical method: and (3) extracting a certain number of patients and normal people, respectively measuring the percutaneous bilirubin of the selected people by using a percutaneous jaundice tester, and fitting the relationship between clinical data and test data by using a statistical method so as to determine the value of the standard color plate. The method can finish the correction of the standard color card of the percutaneous jaundice tester only after sampling and counting are carried out on patients and normal people by medical institutions, and has strong limitation.
Disclosure of Invention
Aiming at the technical problems, the invention provides a method and a device for correcting a calibration color plate for a percutaneous jaundice tester, which can correct a standard color plate for the percutaneous jaundice tester through a prepared bilirubin reagent without being limited to acquiring bilirubin data of patients and normal people through medical institutions, and have more convenient flow.
In a first aspect, an embodiment of the present invention provides a method for correcting a calibration color palette for a percutaneous jaundice tester, including:
measuring the reflectivity of N bilirubin reagents with different concentrations at a preset wavelength by using a spectrophotometer to obtain N reagent reflection data, wherein the concentration range of the bilirubin reagents is determined according to the nominal value of a corrected standard color plate;
performing linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relation between the bilirubin concentration and the reagent reflection data;
measuring the reflectivity of the corrected standard color plate at a preset wavelength for N times by using a spectrophotometer to obtain N color plate reflection data, and obtaining N fitting values according to the linear relation;
and subtracting the fitting value from the nominal value of the corrected standard color plate, summing the difference values and averaging to obtain an error value of the corrected standard color plate.
In one embodiment, the predetermined wavelengths are 460nm and 550 nm.
In one embodiment, the color plate reflection data is:
and acquiring the reflectivities of the corrected standard color plate at the wavelengths of 460nm and 550nm, and taking the logarithm of the ratio of the two reflectivities to obtain the color plate reflection data.
In one embodiment, the bilirubin reagent is obtained by diluting a bilirubin standard with chloroform.
In one embodiment, the spectrophotometer is adjusted to a spot test mode and a reflectance measurement mode is selected.
In a second aspect, an embodiment of the present invention further provides a calibration device for a calibration color plate of a percutaneous jaundice tester, including:
the control set acquisition module is used for measuring the reflectivity of N bilirubin reagents with different concentrations at a preset wavelength by using a spectrophotometer to obtain N reagent reflection data, and the concentration range of the bilirubin reagents is determined according to the nominal value of a corrected standard color plate;
the data fitting module is used for performing linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relation between the bilirubin concentration and the reagent reflection data;
the test set acquisition module is used for measuring the reflectivity of the corrected standard color plate at the preset wavelength for N times by using a spectrophotometer to obtain N color plate reflection data and obtaining N fitting values according to the linear relation;
and the error analysis module is used for subtracting the fitting value from the nominal value of the corrected standard color plate, summing the difference values and averaging to obtain an error value of the corrected standard color plate.
An embodiment of the present invention further provides a computer-readable storage medium, on which a computer program is stored, where the computer program is executed by a processor to implement the method according to any of the above embodiments.
Compared with the prior art, the embodiment of the invention has the beneficial effects that:
according to the calibration method and the calibration device for the calibration color plate for the percutaneous jaundice tester, which are provided by the invention, the reflectivity of the bilirubin concentration reagent at 460nm and 550nm is measured by using the spectrophotometer, so that the standard color plate of the percutaneous jaundice tester is calibrated, a human body sample does not need to be collected manually, the operation is simpler and more convenient, and the accuracy of an error correction result obtained through linear calculation is higher.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic flowchart of a calibration method for a calibration palette of a percutaneous jaundice tester according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a calibration device for a calibration palette for a percutaneous jaundice tester according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be understood that the step numbers used herein are for convenience of description only and are not intended as limitations on the order in which the steps are performed.
It is to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the specification of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
The terms "comprises" and "comprising" indicate the presence of the described features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
The term "and/or" refers to and includes any and all possible combinations of one or more of the associated listed items.
As shown in fig. 1, an embodiment of the present invention provides a schematic flow chart of a calibration method for a percutaneous jaundice tester, which specifically includes:
s11: and measuring the reflectivity of N bilirubin reagents with different concentrations at a preset wavelength by using a spectrophotometer to obtain N reagent reflection data, wherein the concentration range of the bilirubin reagents is determined according to the nominal value of the corrected standard color plate.
In this embodiment, the preset wavelengths are 460nm and 550 nm.
The percutaneous jaundice detector is mainly used for calibrating the bilirubin concentration precipitated under skin tissues of the neonate according to the principle that the bilirubin value of subcutaneous red blood cells of the neonate is related to the light wave density difference of blue light waves (about 460 nm) and green light waves (about 550 nm).
In this example, the bilirubin reagent is obtained by diluting a bilirubin standard with chloroform.
The bilirubin standard substance can be bilirubin powder, the dilution process is operated in a fume hood, and the bilirubin standard substance is kept away from light; in specific embodiments, the bilirubin powder may be diluted to a concentration of the agent in the range of (0-40) mg/dL of at least 5 concentration points, where 0-40 mg/dL is close to the nominal value of the standard color palette being calibrated.
In this embodiment, the spectrophotometer is adjusted to a spot test mode and a reflectance measurement mode is selected.
Specifically, before starting the measurement, the optical path tooling of the spectrophotometer may be equipped with 5 °/0 °, namely: 5 ° incident light and 0 ° outgoing light were used and 2 wavelengths of 460nm and 550nm were set, respectively, and background subtraction was performed using air as a participant at the sample.
S12: and performing linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relation between the bilirubin concentration and the reagent reflection data.
In this embodiment, reflectance R at wavelengths of 460nm and 550nm of the bilirubin reagent may be obtainedd460And Rd550Taking logarithm of the ratio of the two reflectivities to obtain reagent reflection data, wherein the reagent reflection data is ln (R)d460/Rd550)。
Reflecting the reagent by the data ln (R)d460/Rd550) Defined as y, the following linear relationship was obtained by fitting the N reagent reflectance data:
yi＝bxi+a
where i is (1,2, …, N), a is the intercept of the linear fit curve, and b is the slope of the linear fit curve; x is the number ofiIs the bilirubin reagent concentration in mg/dL.
S13: and measuring the reflectivity of the corrected standard color plate at the preset wavelength for N times by using a spectrophotometer to obtain N color plate reflection data, and obtaining N fitting values according to the linear relation.
In this embodiment, the reflectance of the standard color plate to be corrected at wavelengths of 460nm and 550nm is obtained, and the ratio of the two reflectances is logarithmized to obtain the color plate reflectance data, which is ln (R)s460/Rs550)。
Reflection data I for N color platessiHaving a structure ofsi＝ln(Rs460i/Rs550i) Where i ═ (1,2, …, N).
Respectively reflect data I from color platesiSubstituting the linear relation y as bx + a as a variable y, and solving bilirubin concentration values x corresponding to the reflection data of the N color platessiNamely:
s14: and subtracting the fitting value from the nominal value of the corrected standard color plate, summing the difference values and averaging to obtain an error value of the corrected standard color plate.
In this embodiment, the error value e of the corrected standard color plate can be solved according to the following formula:
as shown in fig. 2, an embodiment of the present invention further provides a calibration device for a calibration palette for a percutaneous jaundice tester, which includes a control set obtaining module 101, a data fitting module 102, a test set obtaining module 103, and an error analysis module 104.
The control set acquisition module 101 is configured to measure reflectivities of N bilirubin reagents with different concentrations at preset wavelengths by using a spectrophotometer to obtain N reagent reflection data, and a concentration range of the bilirubin reagent is determined according to a nominal value of a calibrated standard color plate.
The data fitting module 102 is configured to perform linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relationship between the bilirubin concentration and the reagent reflection data.
The test set obtaining module 103 is configured to measure the reflectivity of the corrected standard color plate at a preset wavelength N times by using a spectrophotometer to obtain N color plate reflection data, and obtain N fitting values according to the linear relationship.
The error analysis module 104 is configured to perform a difference between the fitting value and the nominal value of the corrected standard color plate, sum the difference values, and take an average value to obtain an error value of the corrected standard color plate.
Because the content of information interaction, execution process, and the like among the modules in the device is based on the same concept as the method embodiment of the present invention, specific content can be referred to the description in the method embodiment of the present invention, and is not described herein again.
An embodiment of the present invention further provides a computer-readable storage medium, on which a computer program is stored, where the computer program is executed by a processor to implement the method according to any of the above embodiments.
It will be understood by those skilled in the art that all or part of the processes of the methods of the above embodiments may be implemented by a computer program, which may be stored in a computer-readable storage medium, and may include the processes of the embodiments of the methods when executed. The storage medium may be a magnetic disk, an optical disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), or the like.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (7)
1. A correction method of a calibration color plate for a percutaneous jaundice tester is characterized by comprising the following steps:
measuring the reflectivity of N bilirubin reagents with different concentrations at a preset wavelength by using a spectrophotometer to obtain N reagent reflection data, wherein the concentration range of the bilirubin reagents is determined according to the nominal value of a corrected standard color plate;
performing linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relation between the bilirubin concentration and the reagent reflection data;
measuring the reflectivity of the corrected standard color plate at a preset wavelength for N times by using a spectrophotometer to obtain N color plate reflection data, and obtaining N fitting values according to the linear relation;
and subtracting the fitting value from the nominal value of the corrected standard color plate, summing the difference values and averaging to obtain an error value of the corrected standard color plate.
2. The method of calibrating a calibration color plate for a percutaneous jaundice tester of claim 1, wherein the predetermined wavelengths are 460nm and 550 nm.
3. The method of calibrating a color palette for a percutaneous jaundice tester of claim 2, wherein the color palette reflectance data is:
and acquiring the reflectivities of the corrected standard color plate at the wavelengths of 460nm and 550nm, and taking the logarithm of the ratio of the two reflectivities to obtain the color plate reflection data.
4. The method of calibrating a calibration color plate for a percutaneous jaundice tester of claim 1, wherein the bilirubin reagent is obtained by diluting a bilirubin standard with chloroform.
5. The method of calibrating a calibration palette for a percutaneous jaundice tester of claim 1, wherein the spectrophotometer is adjusted to a spot test mode and a reflectance measurement mode is selected.
6. The utility model provides a correcting unit of calibration palette for percutaneous jaundice tester which characterized in that includes:
the control set acquisition module is used for measuring the reflectivity of N bilirubin reagents with different concentrations at a preset wavelength by using a spectrophotometer to obtain N reagent reflection data, and the concentration range of the bilirubin reagents is determined by correcting the nominal value of a standard color plate;
the data fitting module is used for performing linear fitting on the concentration of the bilirubin reagent and the corresponding reagent reflection data to obtain a linear relation between the bilirubin concentration and the reagent reflection data;
the test set acquisition module is used for measuring the reflectivity of the corrected standard color plate at the preset wavelength for N times by using a spectrophotometer to obtain N color plate reflection data and obtaining N fitting values according to the linear relation;
and the error analysis module is used for subtracting the fitting value from the nominal value of the corrected standard color plate, summing the difference values and averaging to obtain an error value of the corrected standard color plate.
7. A computer-readable storage medium, on which a computer program is stored, which, when being executed by a processor, carries out the method according to any one of claims 1 to 5.
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| CN116746917A (en) * | 2023-05-24 | 2023-09-15 | 深圳京柏医疗科技股份有限公司 | Jaundice tester calibrating device |
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