CN112675137A - Cefdinir bulk drug - Google Patents
Cefdinir bulk drug Download PDFInfo
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- CN112675137A CN112675137A CN202011613229.4A CN202011613229A CN112675137A CN 112675137 A CN112675137 A CN 112675137A CN 202011613229 A CN202011613229 A CN 202011613229A CN 112675137 A CN112675137 A CN 112675137A
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- cefdinir
- fat
- powder
- bulk drug
- free sugar
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Abstract
The invention discloses a cefdinir bulk drug, relates to the technical field of drug synthesis, and particularly relates to a cefdinir bulk drug, which comprises the following raw materials: 90-99% of cefdinir, 1-10% of fruity powder, 0.5-2% of a lubricant and 15-22% of fat-free sugar granules, wherein the cefdinir adopts a cefdinir solvent which is liquid without dehydration, the fruity powder is fruit powder which is ground into powder after fruits are dehydrated, the fat-free sugar granules are tasteless and low-sugar granules which are melted when meeting water, and carbon dioxide gas is compressed inside the fat-free sugar granules. The cefdinir bulk drug is prepared by mixing fruity powder with various fruity tastes, so that the formed cefdinir has corresponding fruity taste, can cover bitter taste and avoid greasy taste of children through taste change, and the cefdinir is dissolved in the oral cavity when being taken so as to melt fat-free sugar particles, and at the moment, carbon dioxide overflows in the oral cavity to form a mouth feel similar to carbonated beverage, thereby further being beneficial to reducing the psychological resistance of children when taking the cefdinir.
Description
Technical Field
The invention relates to the technical field of drug synthesis, in particular to a cefdinir bulk drug.
Background
The cefdinir bulk drug is white or yellowish crystalline powder, is oral third-generation cephalosporin, has the advantages of wide antibacterial spectrum, low toxicity and the like, is widely used clinically in the prior various preparations, is tasteless or bitter for oral administration, and can be conveniently swallowed by human bodies by adding a sweetener for improving the comfort level of human body administration.
Although the existing cefdinir bulk drug is convenient to take by adding a sweetener, the cefdinir bulk drug is inconvenient for children to take the cefdinir bulk drug for a long time because the single sweet taste is easy to be greasy for the children to eat for a long time.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a cefdinir bulk drug, and solves the problems that although the existing cefdinir bulk drug is added with a sweetener to be convenient to take, the cefdinir bulk drug is inconvenient for children to take the cefdinir bulk drug for a long time due to the fact that the single sweet taste is easy to be greasy for the children to eat for a long time, and the cefdinir bulk drug is not convenient for the children to take for a long time.
In order to achieve the purpose, the invention is realized by the following technical scheme: the cefdinir bulk drug comprises the following raw materials: 90-99% of cefdinir, 1-10% of fruity powder, 0.5-2% of a lubricant and 15-22% of fat-free sugar granules, wherein the cefdinir adopts a cefdinir solvent which is liquid without dehydration, the fruity powder is fruit powder which is ground into powder after fruits are dehydrated, the fat-free sugar granules are tasteless and low-sugar granules which are melted when meeting water, and carbon dioxide gas is compressed inside the fat-free sugar granules.
The production of the cefdinir bulk drug comprises the following operation steps:
s1, preparing fruit-flavored powder:
fresh fruits are taken, trimmed, sliced or sliced, dehydrated and dried, and then ground into powder particles to obtain fruit flavor powder;
s2, mixing and stirring:
putting the fruity powder prepared in the step S1 into liquid cefdinir, mixing and stirring uniformly, and dehydrating and drying the powdery cefdinir;
s3, compression and tabletting:
adding a lubricant into the powdery cefdinir in the step S2 to humidify the powdery cefdinir, putting the powdery cefdinir and the fat-free sugar particles into a stirring barrel, fully stirring, and pressing the powdery cefdinir and the fat-free sugar particles by a compression molding machine to obtain tablet-shaped cefdinir;
s4, drying tablets:
the tablet-shaped cefdinir is placed in a dust-free environment and naturally dried.
Optionally, in the step S1, the fruit drying temperature is controlled at 32-42 ℃ and the drying time is 11-16 hours until the moisture content of the fruit is reduced to 17-20%.
Optionally, in the step S1, the prepared fruity powder needs to be screened by using a screen, and the particle size of the fruity powder obtained by screening is in the range of 40-50 μm.
Optionally, in the step S2, the rotation speed is controlled at 100-.
Optionally, in the step S3, the ratio of the powdery cefdinir to the lubricant is 1:0.3, and the lubricant may be purified water or glucose solution.
Optionally, in the step S4, the temperature for mixing the fat-free sugar particles and the powdery cefdinir is controlled to be 5-10 ℃ to avoid melting of the fat-free sugar particles, and the stirring speed is controlled to be 50-70 rpm.
Optionally, in the step S4, the particle size range of the fat-free sugar particles is controlled to be 0.7-1mm, the stirring time of the fat-free sugar particles and the powdery cefdinir is controlled to be 0.5-1 hour, and the ratio of the fat-free sugar particles to the powdery cefdinir is 1: 3-6.
Optionally, in the step S5, the tablet-shaped cefdinir is naturally dried at 25 to 28 ℃ at room temperature for 3 to 7 hours.
The invention provides a cefdinir bulk drug, which has the following beneficial effects:
the cefdinir bulk drug is prepared by mixing fruity powder with various fruity tastes, so that the formed cefdinir has corresponding fruity taste, can cover bitter taste and avoid greasy taste of children through taste change, and the cefdinir is dissolved in the oral cavity when being taken so as to melt fat-free sugar particles, and at the moment, carbon dioxide overflows in the oral cavity to form a mouth feel similar to carbonated beverage, thereby further being beneficial to reducing the psychological resistance of children when taking the cefdinir.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
The invention provides the technical scheme that: the cefdinir bulk drug comprises the following raw materials: 90-99% of cefdinir, 1-10% of fruity powder, 0.5-2% of a lubricant and 15-22% of fat-free sugar granules, wherein the cefdinir adopts a cefdinir solvent which is liquid without dehydration, the fruity powder is fruit powder which is ground into powder after fruits are dehydrated, the fat-free sugar granules are tasteless and low-sugar granules which are melted when meeting water, and carbon dioxide gas is compressed inside the fat-free sugar granules.
The production of the cefdinir bulk drug comprises the following operation steps:
s1, preparing fruit-flavored powder:
fresh fruits are taken, trimmed, sliced or sliced, dehydrated and dried, and then ground into powder particles to obtain fruit flavor powder;
s2, mixing and stirring:
putting the fruity powder prepared in the step S1 into liquid cefdinir, mixing and stirring uniformly, and dehydrating and drying the powdery cefdinir;
s3, compression and tabletting:
adding a lubricant into the powdery cefdinir in the step S2 to humidify the powdery cefdinir, putting the powdery cefdinir and the fat-free sugar particles into a stirring barrel, fully stirring, and pressing the powdery cefdinir and the fat-free sugar particles by a compression molding machine to obtain tablet-shaped cefdinir;
s4, drying tablets:
the tablet-shaped cefdinir is placed in a dust-free environment and naturally dried.
In the step S1, the fruit drying temperature is controlled at 32-42 ℃ and the drying time is 11-16 hours until the water content of the fruit is reduced to 17-20%.
In the step S1, the prepared fruity powder needs to be screened by a screen, and the particle size range of the fruity powder obtained by screening is 40-50 μm.
In the step S2, the rotation speed is controlled at 100-.
In the step S3, the ratio of the powdery cefdinir to the lubricant is 1:0.3, and the lubricant can be purified water or glucose solution.
In the step S4, the temperature of mixing the fat-free sugar particles with the powdery cefdinir needs to be controlled at 5-10 ℃ to avoid melting of the fat-free sugar particles, and the stirring speed is controlled at 50-70 rpm.
In the step S4, the particle size of the fat-free sugar particles is controlled to be 0.7-1mm, the stirring time of the fat-free sugar particles and the powdery cefdinir is controlled to be 0.5-1 h, and the ratio of the fat-free sugar particles to the powdery cefdinir is 1: 3-6.
In the step S5, the medicine tablet-shaped cefdinir is naturally dried at the room temperature of 25-28 ℃ for 3-7 hours.
The cefdinir bulk drug is prepared by mixing fruity powder with various fruity tastes, so that the formed cefdinir has corresponding fruity taste, can cover bitter taste and avoid greasy taste of children through taste change, and the cefdinir is dissolved in the oral cavity when being taken so as to melt fat-free sugar particles, and at the moment, carbon dioxide overflows in the oral cavity to form a mouth feel similar to carbonated beverage, thereby further being beneficial to reducing the psychological resistance of children when taking the cefdinir.
To sum up, the cefdinir bulk drug comprises the following operation steps when in use:
s1, preparing fruit-flavored powder: fresh fruits are taken, trimmed, sliced or sliced, dehydrated and dried, and then ground into powder particles to obtain fruit flavor powder;
s2, mixing and stirring: putting the fruity powder prepared in the step S1 into liquid cefdinir, mixing and stirring uniformly, and dehydrating and drying the powdery cefdinir;
s3, compression and tabletting: adding a lubricant into the powdery cefdinir in the step S2 to humidify the powdery cefdinir, putting the powdery cefdinir and the fat-free sugar particles into a stirring barrel, fully stirring, and pressing the powdery cefdinir and the fat-free sugar particles by a compression molding machine to obtain tablet-shaped cefdinir;
s4, drying tablets: the tablet-shaped cefdinir is placed in a dust-free environment and naturally dried.
The cefdinir bulk drug is prepared by mixing fruity powder with various fruity tastes, so that the formed cefdinir has corresponding fruity taste, can cover bitter taste and avoid greasy taste of children through taste change, and the cefdinir is dissolved in the oral cavity when being taken so as to melt fat-free sugar particles, and at the moment, carbon dioxide overflows in the oral cavity to form a mouth feel similar to carbonated beverage, thereby further being beneficial to reducing the psychological resistance of children when taking the cefdinir.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.
Claims (9)
1. Cefdinir bulk drug is characterized in that: the cefdinir bulk drug comprises the following raw materials: 90-99% of cefdinir, 1-10% of fruity powder, 0.5-2% of a lubricant and 15-22% of fat-free sugar granules, wherein the cefdinir adopts a cefdinir solvent which is liquid without dehydration, the fruity powder is fruit powder which is ground into powder after fruits are dehydrated, the fat-free sugar granules are tasteless and low-sugar granules which are melted when meeting water, and carbon dioxide gas is compressed inside the fat-free sugar granules.
2. The cefdinir bulk drug according to claim 1, which is characterized in that: the production of the cefdinir bulk drug comprises the following operation steps:
s1, preparing fruit-flavored powder:
fresh fruits are taken, trimmed, sliced or sliced, dehydrated and dried, and then ground into powder particles to obtain fruit flavor powder;
s2, mixing and stirring:
putting the fruity powder prepared in the step S1 into liquid cefdinir, mixing and stirring uniformly, and dehydrating and drying the powdery cefdinir;
s3, compression and tabletting:
adding a lubricant into the powdery cefdinir in the step S2 to humidify the powdery cefdinir, putting the powdery cefdinir and the fat-free sugar particles into a stirring barrel, fully stirring, and pressing the powdery cefdinir and the fat-free sugar particles by a compression molding machine to obtain tablet-shaped cefdinir;
s4, drying tablets:
the tablet-shaped cefdinir is placed in a dust-free environment and naturally dried.
3. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S1, the fruit drying temperature is controlled at 32-42 ℃ and the drying time is 11-16 hours until the water content of the fruit is reduced to 17-20%.
4. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S1, the prepared fruity powder needs to be screened by a screen, and the particle size range of the fruity powder obtained by screening is 40-50 μm.
5. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S2, the rotation speed is controlled at 100-.
6. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S3, the ratio of the powdery cefdinir to the lubricant is 1:0.3, and the lubricant can be purified water or glucose solution.
7. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S4, the mixing temperature of the fat-free sugar particles and the powdery cefdinir needs to be controlled at 5-10 ℃ to avoid the melting of the fat-free sugar particles, and the stirring speed is controlled at 50-70 r/min.
8. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S4, the particle size range of the fat-free sugar particles is controlled to be 0.7-1mm, the stirring time of the fat-free sugar particles and the powdery cefdinir is controlled to be 0.5-1 h, and the ratio of the fat-free sugar particles to the powdery cefdinir is 1: 3-6.
9. The cefdinir bulk drug according to claim 1, which is characterized in that: in the step S5, the medicine tablet-shaped cefdinir is naturally dried at the room temperature of 25-28 ℃, and the drying time is 3-7 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011613229.4A CN112675137A (en) | 2020-12-30 | 2020-12-30 | Cefdinir bulk drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011613229.4A CN112675137A (en) | 2020-12-30 | 2020-12-30 | Cefdinir bulk drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112675137A true CN112675137A (en) | 2021-04-20 |
Family
ID=75455321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011613229.4A Pending CN112675137A (en) | 2020-12-30 | 2020-12-30 | Cefdinir bulk drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112675137A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977009A (en) * | 2014-05-22 | 2014-08-13 | 常州市亚邦医药研究所有限公司 | Orally-taken medicinal composition containing cefdinir and preparation method thereof |
| CN108348460A (en) * | 2015-09-11 | 2018-07-31 | 安德鲁·吉斯 | A kind of oral granule composition |
-
2020
- 2020-12-30 CN CN202011613229.4A patent/CN112675137A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977009A (en) * | 2014-05-22 | 2014-08-13 | 常州市亚邦医药研究所有限公司 | Orally-taken medicinal composition containing cefdinir and preparation method thereof |
| CN108348460A (en) * | 2015-09-11 | 2018-07-31 | 安德鲁·吉斯 | A kind of oral granule composition |
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Application publication date: 20210420 |
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