CN112672827A - 两相冲洗系统和方法 - Google Patents

两相冲洗系统和方法 Download PDF

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Publication number
CN112672827A
CN112672827A CN202080003660.9A CN202080003660A CN112672827A CN 112672827 A CN112672827 A CN 112672827A CN 202080003660 A CN202080003660 A CN 202080003660A CN 112672827 A CN112672827 A CN 112672827A
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CN
China
Prior art keywords
flow cell
reagent
valve
gas
reagent container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080003660.9A
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English (en)
Chinese (zh)
Inventor
N·沃特森
W·A·科克斯-穆拉纳米
C·德拉特
M·李
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Illumina Inc
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Illumina Inc
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Publication date
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Publication of CN112672827A publication Critical patent/CN112672827A/zh
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN202080003660.9A 2019-05-28 2020-05-27 两相冲洗系统和方法 Pending CN112672827A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962853577P 2019-05-28 2019-05-28
US62/853,577 2019-05-28
PCT/US2020/034666 WO2020243152A1 (en) 2019-05-28 2020-05-27 Two-phase flushing systems and methods

Publications (1)

Publication Number Publication Date
CN112672827A true CN112672827A (zh) 2021-04-16

Family

ID=73550599

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080003660.9A Pending CN112672827A (zh) 2019-05-28 2020-05-27 两相冲洗系统和方法

Country Status (9)

Country Link
US (2) US12005437B2 (https=)
EP (1) EP3976259A4 (https=)
JP (1) JP7504133B2 (https=)
KR (1) KR20220002735A (https=)
CN (1) CN112672827A (https=)
AU (1) AU2020285721B2 (https=)
CA (1) CA3137541A1 (https=)
SG (1) SG11202012800VA (https=)
WO (1) WO2020243152A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117358695A (zh) * 2023-10-10 2024-01-09 中元汇吉生物技术股份有限公司 基因检测两相清洗系统和方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230167933A1 (en) * 2021-11-30 2023-06-01 Applied Materials, Inc. Integrated manifold and switches for fluidic movement

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JPH02228562A (ja) * 1989-03-02 1990-09-11 Jeol Ltd 自動免疫測定装置
US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
US20020028926A1 (en) * 2000-09-07 2002-03-07 Yoshiyuki Shoji Nucleic acid purification method and purification apparatus
CN1517712A (zh) * 2003-01-20 2004-08-04 三星电子株式会社 用于检测生物试样中蛋白质的自动流体装置及其方法
CN1553969A (zh) * 2001-07-16 2004-12-08 Һ�����������·������ú��о��ľ� 整体块、化学输送系统及用于输送超纯化学制品的方法
CN1596369A (zh) * 2002-07-31 2005-03-16 株式会社东芝 碱基序列检测装置及碱基序列自动解析装置
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JP2008298755A (ja) * 2007-06-04 2008-12-11 Hitachi High-Technologies Corp 医用光度計
CN101482571A (zh) * 2008-01-07 2009-07-15 霍夫曼-拉罗奇有限公司 试剂盒
JP2010256050A (ja) * 2009-04-22 2010-11-11 Hitachi High-Technologies Corp 自動分析装置
CN101960315A (zh) * 2008-02-29 2011-01-26 贝克曼库尔特公司 清洗液体处理探针的装置和方法
JP2011247617A (ja) * 2010-05-24 2011-12-08 Hitachi High-Technologies Corp 自動分析装置
CN102735812A (zh) * 2012-06-15 2012-10-17 中国科学院长春应用化学研究所 一种生化需氧量的检测方法
JP2015040804A (ja) * 2013-08-23 2015-03-02 株式会社日立ハイテクノロジーズ 自動分析装置
US20160319350A1 (en) * 2013-08-08 2016-11-03 Illumina, Inc. Fluidic system for reagent delivery to a flow cell
CN106093256A (zh) * 2015-04-30 2016-11-09 塞莫费雪科学有限公司 用于减少耗气量的方法和设备
US20170144155A1 (en) * 2014-06-05 2017-05-25 Illumina, Inc. Systems and methods including a rotary valve for at least one of sample preparation or sample analysis
US20170333904A1 (en) * 2016-05-20 2017-11-23 Eli Lyons Sensor system and method for disease detection
US20180188279A1 (en) * 2017-01-05 2018-07-05 Illumina, Inc. Reagent mixing system and methods
US20180280975A1 (en) * 2017-04-04 2018-10-04 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions

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US4168294A (en) * 1977-02-14 1979-09-18 Claudio Calzi Instrument for photometric analyses
JPH02228562A (ja) * 1989-03-02 1990-09-11 Jeol Ltd 自動免疫測定装置
US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
US20020028926A1 (en) * 2000-09-07 2002-03-07 Yoshiyuki Shoji Nucleic acid purification method and purification apparatus
CN1553969A (zh) * 2001-07-16 2004-12-08 Һ�����������·������ú��о��ľ� 整体块、化学输送系统及用于输送超纯化学制品的方法
CN1596369A (zh) * 2002-07-31 2005-03-16 株式会社东芝 碱基序列检测装置及碱基序列自动解析装置
CN1517712A (zh) * 2003-01-20 2004-08-04 三星电子株式会社 用于检测生物试样中蛋白质的自动流体装置及其方法
CN1767899A (zh) * 2003-04-04 2006-05-03 皇家飞利浦电子股份有限公司 多微通道中的流体分隔
JP2008298755A (ja) * 2007-06-04 2008-12-11 Hitachi High-Technologies Corp 医用光度計
CN101482571A (zh) * 2008-01-07 2009-07-15 霍夫曼-拉罗奇有限公司 试剂盒
CN101960315A (zh) * 2008-02-29 2011-01-26 贝克曼库尔特公司 清洗液体处理探针的装置和方法
JP2010256050A (ja) * 2009-04-22 2010-11-11 Hitachi High-Technologies Corp 自動分析装置
JP2011247617A (ja) * 2010-05-24 2011-12-08 Hitachi High-Technologies Corp 自動分析装置
CN102735812A (zh) * 2012-06-15 2012-10-17 中国科学院长春应用化学研究所 一种生化需氧量的检测方法
US20160319350A1 (en) * 2013-08-08 2016-11-03 Illumina, Inc. Fluidic system for reagent delivery to a flow cell
JP2015040804A (ja) * 2013-08-23 2015-03-02 株式会社日立ハイテクノロジーズ 自動分析装置
US20170144155A1 (en) * 2014-06-05 2017-05-25 Illumina, Inc. Systems and methods including a rotary valve for at least one of sample preparation or sample analysis
CN106093256A (zh) * 2015-04-30 2016-11-09 塞莫费雪科学有限公司 用于减少耗气量的方法和设备
US20170333904A1 (en) * 2016-05-20 2017-11-23 Eli Lyons Sensor system and method for disease detection
US20180188279A1 (en) * 2017-01-05 2018-07-05 Illumina, Inc. Reagent mixing system and methods
US20180280975A1 (en) * 2017-04-04 2018-10-04 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117358695A (zh) * 2023-10-10 2024-01-09 中元汇吉生物技术股份有限公司 基因检测两相清洗系统和方法

Also Published As

Publication number Publication date
US12005437B2 (en) 2024-06-11
US20200376482A1 (en) 2020-12-03
AU2020285721B2 (en) 2025-08-07
SG11202012800VA (en) 2021-01-28
WO2020243152A1 (en) 2020-12-03
JP7504133B2 (ja) 2024-06-21
EP3976259A1 (en) 2022-04-06
CA3137541A1 (en) 2020-12-03
US20240299930A1 (en) 2024-09-12
JP2022534940A (ja) 2022-08-04
AU2020285721A1 (en) 2022-01-06
KR20220002735A (ko) 2022-01-06
EP3976259A4 (en) 2023-06-07

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